what studies on Curcumin have been published in medical literature and science journals?

 The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis
Pharmaceuticals | December 2021
Curcumin is a polyphenol with strong antioxidant and anti-inflammatory activity. It is also the primary active component of the Indian spice turmeric (Curcuma longa)and curry powders. Animal studies have also confirmed that curcumin has protective effects against cognitive decline, both in aging rhesus monkeys and in a streptozotocin-induced dementia rat model. Specifically, curcumin has been found to exhibit various selective effects, including preventing atrophic change and cell loss in the prefrontal cortex compared to the hippocampus, decreasing neuroinflammation compared to promoting neurogenesis, and more positive effects on working memory than on recognition. Following at least 8 weeks of nutritional supplementation, curcumin was found to improve working memory more than a placebo regimen. The results in the cognitive domain of processing speed were notable, with a borderline p-value, which may be significant if further trials are included. The protective effect of curcumin in the prefrontal cortex has also been demonstrated in animal models. Noorafshan et al. used three different neural damage rat models, including stress-induced, sulfite-induced, and sleep deprivation, and found that curcumin could prevent structural deterioration in neurons and glial cells, and could also counteract behavioral changes. This showed that curcumin had a direct protective effect on the prefrontal cortex and may explain why curcumin was able to effectively improve working memory, as observed in our meta-analysis.

Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro
Viruses | December 2021
Turmeric root, also known as Curcuma longa, is broadly used as a spice widely cultivated in Southeast Asia. The rhizome of Curcuma longa contains several structurally related curcuminoids. Sixty to 75% of the curcuminoid content consists of curcumin, also known as diferuloylmethane.As early as 1815, the bioactive ingredient curcumin was first isolated from turmeric root by Vogel and Pelletier. Curcumin reveals a broad spectrum of bioactivities such as antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, and hepatoprotective activities.  In addition to the antiviral activity, curcumin also exhibits anti-inflammatory effects. Randomized controlled trials indicated a significant downregulation of the human tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6) through curcumin.

Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain
Antioxidants | February 20
Curcumin is an active component of turmeric (Curcuma longa) which is widely used as a food additive in Indian cuisines and Ayurvedic medicines. Previously, researchers have reported the neuroprotective effect of curcumin in various neurodegenerative diseases. In our study on dim light-induced neurodegeneration, we have shown the antioxidant effects of curcumin. Other researchers have also highlighted the anti-inflammatory and antioxidant effects of curcumin. Curcumin plays an effective role as a natural therapeutic drug to combat Cd-induced behavioral impairment by regulating oxidative stress and modulating inflammatory markers. Curcumin was found to improve the behavior of mice through reduction of prefrontal cortex oxidative stress and neuroinflammation as well as promotion of hippocampal neurogenesis. Therefore, curcumin supplementation in food and diet could reduce the deleterious effect of heavy metal exposure.

Antiviral Therapeutic Potential of Curcumin
Molecules | December 2021
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), also called diferuloylmethane, is the best example of a plant derivative with an enormous number of therapeutic properties, such as anti-oxidant, anti-carcinogenic, anti-diabetic, anti-microbial, and antiviral activity. In traditional Indian Ayurvedic medicine, curcumin was widely applied in many therapeutic remedies. This compound is a natural polyphenolic substance and an active form of the traditional herb that is found in the rhizome of Curcuma longa (turmeric). Curcumin is the main molecule of the curcuminoids; the curcuminoids are comprised of curcumin (77%) as well as includes bisdemethoxycurcumin (BDMC) (17%) and demethoxycurcumin (DMC) (6%). The first suggestion that curcumin had antiviral properties came in the 1990s, with the discovery that curcumin and curcumin boron complexes could inhibit the human immunodeficiency virus (HIV). Since then, numerous studies have found that curcumin has antiviral activity against a diverse set of viruses, including both RNA and DNA viruses, both enveloped and non-enveloped. Multiple selected studies were on different types of human viruses, including human immunodeficiency virus (nine studies), hepatitis C virus (five studies), human cytomegalovirus (three studies), hepatitis B virus (four studies), herpes simplex viruses (four studies), dengue virus (four studies), enterovirus 71 (two studies), human T lymphocyte virus (two studies), vesicular stomatitis virus (two studies), and respiratory syncytial virus (two studies). There was one study for viruses including zika and chikungunya, coronavirus, Rift Valley fever virus, human norovirus, coxsackievirus B3, Japanese encephalitis virus, and viral hemorrhagic septicemia virus.  27 studies showed that curcumin reduced the production of infectious particles in various infected cells in a dose-dependent manner.

Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and nonalcoholic fatty liver disease (NAFLD)
Food & Function | December 2021
A systematic search, through prominent online databases such as MEDLINE, Scopus, and Google Scholar was done focusing on randomized controlled trials (RCTs) reporting on the impact of curcumin supplementation in individuals with diverse metabolic complications, including obesity, type 2 diabetes and nonalcoholic fatty liver disease. Summarized findings suggest that curcumin supplementation can significantly reduce blood glucose and triglycerides levels, including markers of liver function like alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with type 2 diabetes and nonalcoholic fatty liver disease. Importantly, this effect was consistent with the reduction of predominant markers of oxidative stress and inflammation, such as the levels of malonaldehyde (MDA), tumor necrosis factor-alpha (TNF-α), high sensitivity C-reactive protein (hs-CRP) and monocyte chemoattractant protein-1 (MCP-1) in these patients. RCTs suggest that curcumin is beneficial in ameliorating some metabolic complications.

Curcumin as a Possible Treatment for COVID-19-Induced Anosmia and Ageusia
Cureus | December 2021
Curcumin, the main component of the spice turmeric, is derived from the rhizome of the plant Curcuma longa. Beneficial effects of curcumin have been reported over centuries in the treatment of various ailments, from oncological to autoimmune disorders. Curcumin has been observed to block pro-inflammatory regulators and signaling pathways, including inhibiting nuclear factor (NF)-kappa B activation and suppressing tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), monocyte chemotactic protein-1 (MCP-1), prostaglandin E2, and cyclooxygenase-II, among others. Curcumin has been shown to bind and block the active site of Mpro, the main protease utilized by COVID-19 to produce proteins required for viral replication from viral genomic RNA. Curcumin may also hinder the formation of the COVID-19 spike protein-ACE2 complex, preventing viral entry into cells. The anti-inflammatory action of curcumin may reduce nasal mucosal swelling.

Antioxidant effects of curcumin and neuroaging
Genetics, Neurology, Behavior, and Diet | December 2021
Curcumin, a plant-based polyphenol, is known to scavenge free radicals and promote antioxidant activity. This chapter gives an overview of the molecular evidence by brain imaging studies is reviewed. There is preliminary evidence for curcumin improving memory and decreasing amyloid-β plaque accumulation. Consequently, curcumin has potential as a therapy in aging and aging-related disorders.

Curcumin in Metabolic Health and Disease
Nutrients  | December 2021
In recent years, epidemiological studies have suggested that metabolic disorders are nutritionally dependent. A healthy diet that is rich in polyphenols may be beneficial in the treatment of metabolic diseases such as polycystic ovary syndrome, metabolic syndrome, non-alcoholic fatty liver disease, cardiovascular disease, and, in particular, atherosclerosis. Curcumin is a polyphenol found in turmeric and has been reported to have antioxidant, anti-inflammatory, hepatoprotective, anti-atherosclerotic, and antidiabetic properties, among others.

Targets of Curcumin against Colorectal Cancer and the Correlation with Tumor-Infiltrating Immune Cells
Evidence-Based Complementary and Alternative Medicine | December 2021
In recent years, more and more studies have shown that curcumin has great potential in the treatment of colorectal cancer. Curcuma longa L., commonly known as turmeric, is a rhizomatous herb of the ginger (Zingiberaceae) family. Curcumin is a lipophilic polyphenol compound extracted from the Zingiberaceae family, which lowers blood glucose and has anticancer, anti-inflammation, and antiaging effects. Howells et al. confirmed that curcumin is a safe and well-tolerated adjuvant chemotherapy drug for folinic acid/5-fluorouracil/oxaliplatin chemotherapy (FOLFOX) chemotherapy of metastatic colorectal cancer. In a clinical trial, curcumin has been proved to promote the transformation of Treg cells to Th1 cells and enhance the production of interferon-γ, supporting the antitumor effect of curcumin in colorectal cancer. The clinical efficacy of curcumin in the treatment of colorectal cancer has been recognized. Subsequent in vivo experiments confirmed that curcumin can reduce inflammation and colorectal cancer formation in mouse models. These research results showed that curcumin has many potential effects and has definite therapeutic effects on colorectal cancer . In conclusion, in this study, we identified the key targets of curcumin in colorectal cancer inhibition through the combination of network pharmacology, molecular docking, and tumor immune microenvironment analysis. The mechanism of action of curcumin is binding to AKT1, STAT3, and EGFR by hydrogen bond, hydrophobic effect, and π-cation bond.

The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases
Neuroimmunomodulation | December 2021
Curcumin is the main component of a yellow pigment, commonly called diferuloylmethane, and is an active ingredient in the rhizome of the herb Curcuma longa that represents various biomedical applications. Curcumin has also been traditionally used for its medicinal benefits and wound healing for centuries. However, it was first applied as a drug to treat biliary disease in 1937. Curcumin is a lipophilic polyphenol that is relatively stable in the acidic pH but decomposes in neutral-basic conditions. Curcumin contains approximately 77% diferuloylmethane, 17% dimethoxycurcumin, and 6% bisdemethoxycurcumin. Nowadays, curcumin (C21H20O6) has important roles in the attenuation of progression of some NDs because of its anti-amyloid and anti-inflammatory agents. In addition, curcumin also has several benefits, such as being safe, inexpensive, and readily available polyphenol that can cross the blood brain barrier, thus attracting researchers to use it for treating neurodegenerative diseases.  Curcumin is an NF-κB inhibitor by interrupting ZO-1 expression and localization, MLC phosphorylation, and ROS generation inhibition, which constrains disruption of the BBB by Th17 cells. Furthermore, curcumin, through its NF-κB inhibitory effect, causes intestine dendritic cell differentiation into tolerogenic phenotypes, as well as naive T cells to differentiate into FoxP3+ regulatory T cells (intestine protective, Treg). Thus, curcumin can prevent colitis, due to its anti-inflammatory function. Curcumin has a critical role in transcription factor regulation. Furthermore, curcumin can regulate cytokines, adhesion molecules, protein kinases, redox status, and inflammation-associated enzymes. The pharmacological activities of curcumin are antimicrobial, anti-inflammatory, antioxidant, and anticarcinogenic. It also exhibits potent immunoregulatory activities that can modulate the T cells, B cells, neutrophils, natural killer cells, and macrophage activation and function. Curcumin has been shown to be protective for several cells, including astrocytes, neurons, microglia, and different part of the CNS such as hippocampal, mesencephalic, cortical, and spinal cord. A multiple sclerosis study showed that curcumin regulates T-cell responses to IL-12 by blocking IL-12 production, and IL-12 signaling, through inhibiting JAK-STAT signaling activation. Thus, it has been suggested that curcumin could be used for treating multiple sclerosis and other Th1-cell-mediated inflammatory diseases. Furthermore, curcumin at high doses can directly induce T-cell apoptosis and inhibit T-cell proliferation through blocking of the IL-2 signaling pathway, high-affinity IL-2R, and interfering with IL-2R signaling. These data indicate that curcumin has immunosuppressive effects on many pathways. Thus, curcumin, through its proinflammatory cytokines, decreases TNF-α/β, IL-1, IL-6, and IL-8, and COX-2 provides a therapeutic effect by reducing inflammatory conditions. Curcumin can cross blood brain barrier and, by inhibiting proinflammatory cytokines, can regulate homeostasis of the CNS. The blood brain barrier has a crucial role in controlling the homeostasis of the brain microenvironment. Thus, because autoreactive T-cell penetration plays a key role in MS lesion development, the role of curcumin to protect the blood brain barrier could reduce the severity of MS. Curcumin also decreases the severity of chronic inflammatory diseases, such as rheumatoid arthritis, asthma, AD, and cancer. In phase II clinical trial, curcumin was used orally in a mouse model of colorectal cancer. It has been demonstrated that curcumin can prevent carcinogenesis through different mechanisms such as reduction of cyclooxygenases 1 and 2, 5-lipoxygenase, prostaglandin E2 (PGE2), and 5-hydroxyeicosatetraenoic acid production inhibition. Fortunately, curcumin via inhibition of NF-κB signaling pathways can improve the effects of some chemotherapy drugs. For example, in the mouse model of human breast cancer, curcumin, in conjunction with paclitaxel, can slow breast cancer progression and metastasis to the lung. According to Alavez et al., curcumin, through its involvement in the regulation of protein homeostasis, can increase life span in several species. Curcumin, as a natural cost-effective product with proven pharmacological safety, has strong antioxidant and anti-inflammatory effects through modulating many cellular signaling pathways.

Effect of curcumin supplement or placebo in delayed onset muscle soreness: a systematic review and meta-analysis
Bulletin of the National Research Centre | December 2021
Curcumin is a natural polyphenolic substance extracted from turmeric. It has various physiological effects, such as membrane protective effects and tumor necrotic factor TNF-α. This review suggested that persons who took curcumin supplement before exercise have pain score of about 1 score lower than those who took placebo in and post-exercise at 1, 2, 3 and 4 days. For indirect markers of muscle damage, the persons who took curcumin supplement before exercise have lower CK, TNF and IL score than those who took placebo. From a review of previous meta-analysis (Fang and Nasir 2021), curcumin has efficacy in reducing CK serum levels and muscle soreness index among adults. Therefore, curcumin may be known as a priority EIMD recovery agent in interventions.  To conclude, curcumin supplement has reduced muscle soreness and CK after exercise after 1, 2, 3, and 4 days when compared to placebo.

Curcumin and Its Potential Impact on Microbiota
Nutrients | December 2021
Curcumin is a polyphenol substance isolated from the rhizome of Zingiberaceae and Araceae plants. It is a major active constituent of turmeric, a common Asian spice used as a dietary spice, food-coloring, as a herbal remedy, and in the beverage industries. Its bioactive components have been investigated recently [1,2]. Diferuloylmethane (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), which is commonly referred to as curcumin, has been shown to have activity at the cellular level, by signaling multiple molecules. In addition it exerts antioxidant and anti-inflammatory properties. It may have many therapeutic effects, having exhibited antitumor, chemosensitizing, hepatoprotective, lipid-modifying, and neuroprotective effects. Piperine is a natural alkaloid that is found in black pepper intestine. As Hewlings and Kalman emphasized in their work, piperine has been associated with an increase in the bioavailability of curcumin by 2000%. Polyphenols, such as curcuminoids, are naturally occurring bioactive compounds that, due to their antioxidant abilities, play important roles in human nutrition. A substantial amount of promising evidence has indicated that curcumin may be capable of preventing and combating several metabolic syndromes, cancer, and obesity, and may even play a neuroprotective role. The metabolism of curcumin, which occurs in the intestine, enhances its biological activity and, as a consequence, biotransforms it into active metabolites, which may promote beneficial effects in the gut microbiota.

Curcumin as a great contributor for the treatment and mitigation of colorectal cancer
Experimental Gerontology | December 2021
This review mainly brings out the correlation between the curcumin and its use for the mitigation of colorectal cancer, the use of curcumin as a chemotherapeutic agent, chemosensitizer, and in a combination and synergistic approach. The pharmacokinetics and pharmacodynamics properties of curcumin and its formulation approach helps in giving an idea to develop new approaches for the treatment of colorectal cancer using curcumin.

Protective effect of the association of curcumin with piperine on prostatic lesions
Food and Chemical Toxicology | December 2021
Curcumin plus piperine reduce malignant effects of BPA in prostate.  Inflammation provoked to BPA in the prostate was minimized by curcumin and piperine. Curcumin and piperine helped to minimize carcinogenesis. Thus, these phytochemicals minimize the deleterious action of BPA in prostatic lobes, especially when administered in association. The protective action of curcumin and piperine consumption is associated with weight loss, anti-inflammatory potential, and control of prostate epithelial cell homeostasis.

The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer
Phytomedicine | December 2021
This study evaluated the immune-modulating effects of Curcumin, which has well-established anti-cancer and chemopreventive properties, and its long-term safety as a phytochemical drug. We found that Curcumin decreased the expression of IC ligands such as PD-L1, PD-L2, and Galectin-9 in HNSCC, leading to regulation of epithelial-to-mesenchymal transition-associated tumor invasion. Curcumin also effectively restored the ability of CD8+ cytotoxic T cells to lyse cancer cells. To evaluate the effect of Curcumin on the TME further, the 4-NQO oral cancer model was used. Curcumin increased T-cell proliferation, tumor-infiltrating lymphocytes (TILs), and effector cytokines, and decreased the expression of PD-1, TIM-3, suppressive IC receptors and their ligands (PD-L1, PD-L2, and Galectin-9) in the TME, implying reinvigoration of the exhausted CD8+ T cells. In addition, Curcumin inhibited expression of CD4+CD25+FoxP3+ Treg cells as well as PD-1 and TIM-3. These results show that Curcumin reinvigorates defective T cells via multiple (PD-1 and TIM-3) and multi-level (IC receptors and its ligands) IC axis suppression, thus providing a rationale to combine Curcumin with conventional targeted therapy or ICB as a multi-faceted approach for treating patients with HNSCC.

The efficacy of high and low dose curcumin in knee osteoarthritis: A systematic review and meta-analysis
Complementary Therapies in Medicine | December 2021
Curcuminoids have been shown to possess multiple pharmacological effects, such as anti-inflammatory, anti-oxidative, anti-hyperlipidaemic, and anti-platelet effects, and also to relieve pain and reduce swelling. These properties can be attributed to curcumin acting as an inhibitor of the nuclear factor-kappa β (NF-κβ) pathway and a scavenger of reactive oxygen and nitrogen species. Curcuminoids are employed as adjunctive treatment for rheumatoid arthritis, degenerative neural disease, some cancers, and polycystic ovary disease. Recent randomized controlled trials) have revealed that curcumin has similar effects on pain relief NSAID may lower the NSAID dosage needed and reduce its side effects. Additionally, a recent study by Shep et al. reported less rescue medication use and fewer AEs in patients taking combined curcuminoid and diclofenac than in those taking diclofenac alone. Previous meta-analyses have shown that curcuminoids have beneficial effects on knee OA. Low- and high-dose curcuminoids have similar pain relief effects and adverse events in knee OA.  Curcuminoids are associated with better pain relief than non-steroid anti-inflammatory drugs.

Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis
Complementary Therapies in Medicine | December 2021
Furthermore, more duration (> 8 weeks) and more dosage of curcumin (more than 500 mg) is more related to reduction in ESR and CRP in adult patients with rheumatoid arthritis and ulcerative colitis in comparison with the control group.

Curcumin prevents arsenic-induced carcinogenesis
Chinese Medical Journal | December 2021
Curcumin, an acidic polyphenol compound has anti-inflammatory and anti-tumor effects. This natural chemopreventive agent, derived from rhizomes of curcuma species, provides antioxidant, anti-tumor, and anti-proliferative efficacy. Curcumin blocks cancer development by modulating multiple signaling pathways. Researchers have previously provided novel perceptions about the mechanisms of curcumin action in gastric cancer cell growth inhibition and its therapeutic strategies for gastric cancer control. Therefore, curcumin could be considered a novel therapeutic strategy to control gastric cancer cell growth. Some studies have emphasized the importance of curcumin in lung cancer treatment and the potential utility of curcumin as a method for improving therapeutic outcome. Curcumin suppressed gemcitabine-resistant non-small cell lung cancer cell proliferation and induced apoptosis. Curcumin upregulated the expression of lncRNA-MEG3 and PTEN. Previous studies have also showed that curcumin has potential clinical application in gemcitabine-resistant non-small cell lung cancer treatment for its anti-tumor activity. Furthermore, curcumin also showed anti-inflammatory activity in the kidney. Another study identified curcumin as a common inhibitor of NLRP3 inflammasome activation and revealed that curcumin repressed inflammation. In view of the various advantages and characteristics of curcumin, its anti-tumor effect has attracted the attention of researchers, and has good application prospect in the prevention and treatment of lung cancer. Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion, and metastasis, induction of tumor apoptosis, increase in chemotherapeutic sensitivity, and regulation of cell cycle and cancer stem cells, indicating that curcumin has strong therapeutic potential in modulating the progression of various cancers. Numerous studies have provided evidence that curcumin protects against neurotoxicity, genotoxicity, and DNA damage in vivo and in vitro. To date, more than 100 clinical trials have been completed with curcumin, all of which have demonstrated its safety, tolerability, and effectiveness against various chronic diseases, including various cancers, diabetes, obesity, and cardiovascular, pulmonary, neurological, and autoimmune diseases in humans. Curcumin may represent a useful supplement to improve chronic inflammation and prevent carcinogenic changes in patients. These studies have indicated that curcumin is a promising molecule for the prevention and treatment of cancer. In summary, in the first stage of As3+-induced carcinogenesis, curcumin activates Nrf2, decreases ROS, and induces autophagy in normal cells to prevent As3+-induced cell transformation. In the second stage, curcumin inhibits constitutive expression of Nrf2 and promotion of ROS, apoptosis, and inhibition of angiogenesis in AsT cells to prevent tumorigenesis. Our results suggest that antioxidant natural compounds such as curcumin should be evaluated further as potential candidates for complementary therapy for As3+-induced carcinogenesis.

Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by curcumin
Bioengineered | November 2021
Curcumin is a natural polyphenol compound extracted from Curcuma tuber and Curcuma rhizome. It is believed to possess the ability of anti-tumor, anti-inflammatory, antioxidant and anti-fibrosis effects. Studies have shown that curcumin could inhibit nuclear factor-κB (NF-κB) mediated interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α) release in db/db diabetic mice, and further reduce the inflammatory reaction of mouse liver. In obese rats fed with high fat diet and obese mice with leptin gene deficiency,  curcumin can inhibit the secretion of TNF and monocyte chemoattractant protein-1 (MCP-1), improve inflammatory response, and reduce the levels of blood glucose and glycosylated hemoglobin. Clinical trials indicated that oral curcumin can improve the function of islet B cells in prediabetic patients, reduce insulin resistance, prevent progression to type 2 diabetes. Therefore, curcumin has good clinical application prospects. In this study, we demonstrated that curcumin could improve the intestinal integrity in the type 2 diabetes animal model, and promoted the expression of ZO-1 and occludin. In addition, the hyperglycemia and insulin resistance of type 2 diabetes rats were relieved by curcumin. The suppressive effect of curcumin on TLR4/NF-κB was also observed. Curcumin also improve the gut microbiota dysbiosis in type 2 diabetes Some studies have indicated the protective role of curcumin in intestinal barrier of diabetes. Their conclusions that curcumin could improve the intestinal barrier function are in line with our study. In this study, we found that the significant increase of LPS caused by HFD could be remarkably reduced by curcumin. We demonstrated that curcumin could improve the intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats. Therefore, curcumin might be a potential therapeutic agent for the treatment of type 2 diabetes.

Neuroprotective Effects of Curcumin in Methamphetamine-Induced Toxicity
Molecules | November  2021
Curcumin, a natural polyphenol extracted from rhizome of the Curcuma longa L, has received great attention for its multiple potential health benefits as well as disease prevention. For instance, curcumin protects against toxic agents acting on the human body, including the nervous system. In detail, curcumin possesses, among others, strong effects as an autophagy activator. The present data provide evidence that curcumin counteracts the neurotoxic effects induced by methamphetamine by promoting autophagy.  In recent years, curcumin has received great attention for its multiple potential health benefits as well as disease prevention. Curcumin has been explored for its multiple biological activities mostly focusing on autophagy activation, which is considered to be relevant to counteract various toxicants and disease conditions.

Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms
Molecules | November 2021
Curcumin, the main polyphenolic compound of turmeric, has attracted significant attention owing to its biological effects, such as anti- tumor, anti-inflammatory, immunomodulating, antioxidant, antimicrobial, and antiviral activities; therefore, it has been proposed that curcumin may be a potential treatment against COVID-19. Notably, it has been observed that the consumption of curcuminoids leads to a significant reduction in circulating levels of C-reactive protein and decreases the expression of proinflammatory cytokines, including IL-1β, IL-6, IL-8, and TNF-α, demonstrating its anti-inflammatory capacity; it is important to highlight that this cytokines has been correlated with severe illness. Moreover, in macrophages, it has been observed that curcumin inhibits NLR family pyrin domain containing 3 (NLRP3) inflammasome activation, which plays a significant role in the development of inflammatory diseases. Additionally, curcumin exhibits its inhibitory activity against the replication of diverse viruses, such as dengue virus, hepatitis B virus, zika virus, influenza A virus, and chikungunya virus. Curcumin can exert antiviral effects directly on the viral particle or at different stages of the replicative cycle by interacting with viral proteins or by modulating cellular processes or pathways crucial for viral replication. Specifically for SARS-CoV-2, studies in silico (computer modeling) have reported that curcumin exhibits favorable binding affinities with the spike protein of the virus, as well as with its main cellular receptor, ACE2. These results suggest that curcumin has the ability to interfere with the entry of the virus into the cell. Furthermore, it has been reported that curcumin can affect the expression of other key molecules in the entry and decay of the virus, such as TMPRS22, Cat B, and L. The cumulative evidence suggests that curcumin could be an effective treatment strategy to complement the COVID-19 clinical management. Further, it has been persistently reported that curcumin has anti-inflammatory effects on in vivo models, such as atherosclerosis, multiple sclerosisnd inhibiting the production of pro-inflammatory cytokines and chemokines. In this sense, it has been shown that despite the low bioavailability of curcumin, in two models of chronic disease, this compound has anti-inflammatory effects at low doses, via IL-10 production. Moreover, the ability of curcumin to alter the inflammatory state through the modulation of its regulatory elements can prevent the onset of the cytokine storm.  Evidence presented in this article suggests that curcumin represents a promising compound for developing therapy against SARS-CoV2. In this study, curcumin showed high cytotoxicity at 20 µg/mL in Vero E6 cells. In conclusion, curcumin showed in vitro antiviral activity against SARS-CoV-2, with different treatment strategies, which suggest the inhibition at different stages of the replicative cycle; furthermore, these effects seem to be independent of the virus strain/variant. This antiviral effect, together with the observed immunomodulatory properties, suggests that curcumin could be a promising compound for the treatment of COVID-19 patients.

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence
BioMed Research International | November 2021
Several lines of evidence highlighted a pleiotropic potential of curcumin towards several human diseases, such as malignancies, skin and immune-related disorders, cardiovascular diseases, pulmonary and renal fibrosis, nonalcoholic fatty liver disease (NAFLD), fatigue, neuropathic pain, bone and muscle loss, neurodegenerative disease, ocular diseases, leprosy, osteoporosis, leishmaniosis, and HIV infection. Curcumin supplementation in human melanoma cells induces growth arrest and then apoptosis. Other studies also reported that curcumin may target oncogene expression, angiogenesis, invasion, and metastatic dissemination. Alongside with antitumorigenic activity, curcumin was also shown to induce antimicrobial, antioxidant, antiglycemic, antiseptic, and analgesic effects. With regard to inflammation, curcumin stimulates a xenobiotic response with upregulation of defense genes and suppression of proinflammatory transcription factors and cytokines. Moreover, several studies indicated that curcumin and may be used as senolytic and anti-inflammatory agents for senescent cells.  As reported by Banji et al., curcumin(40 mg/kg) and piperine (12 mg/kg), especially when combined, counteract D-gal-induced senescence in male Wistar rats by targeting OS and lipofuscin deposition, finally leading to higher hippocampal volume and function with improved spatial memory
. Aging and senescence are complex processes leading to organ dysfunction. Despite being permanent, delaying the occurrence of these processes is a reliable target, and curcumin might be a promising candidate for this purpose. Nevertheless, evidence from clinical studies on the long-term effects of curcumin on age-related pathological events remains largely understudied. While several strategies to enhance the systemic bioavailability of curcumin have been suggested, the effects of long-term therapy with such bioavailability-boosted curcumin preparations is not fully known, and increased concentrations may even lead to opposite results. Pleiotropic benefits of curcumin supplementation involve the control of aging genes, OS, and inflammation in both the vascular system and the central nervous system. Further studies are warranted to clarify the mechanisms of curcumin function for potential clinical application.

Is Curcumin the Answer to Future Chemotherapy Cocktail?
Molecules | November 2021
Curcumin, also regarded as diferuloylmethane, is a yellow polyphenol extracted from the rhizome of the Curcuma longa (turmeric) plant, belonging to the Zingiberaceae family. Indigenous in south-eastern and southern tropical Asia, curcumin is traditionally applied for pain-relieving and wound healing effects. Commercial curcumin products contain approximately 77 % curcumin, 18 % demethoxycurcumin and 5 % bisdemethoxycurcumin. Out of those curcuminoids, curcumin exhibits the most potent medicinal properties as compared to demethoxycurcumin and bisdemethoxycurcumin. A growing body of evidence has demonstrated the benefits of curcumin in treating various diseases, including metabolic syndromes, hyperlipidaemia, inflammatory skin conditions, neurodegeneration and rheumatoid arthritis. These clinical benefits are attributed to the anti-inflammatory, anti-oxidant, and wound healing activities of curcumin. Moreover, curcumin can impede pathogenic infections by exerting a broad spectrum of anti-bacterial, anti-fungal and anti-viral activities. Enormous attention has given to the exploration of anticancer properties in curcumin. To date, curcumin has shown its anticancer benefits in numerous cancers such as breast cancer, colorectal cancer, lung cancer, pancreatic cancer and prostate cancer. In fact, these anticancer effects depicted by curcumin are highly associated with the modulation of several oncogenic signalling pathways, which are essential in cancer development. Curcumin constrains these oncogenic signalling pathways and further limits the downstream pro-tumorigenic activities. In vitro studies illustrated that curcumin treatment limited the proliferation and caused cell cycle arrest in HT-29 colon cancer cells and PLC/PRF/5 liver cancer cells via the inhibition of cyclin D1, with the downregulation of NF-κB and cyclooxygenase-2 (COX-2) signalling. pathways and inhibition of MMP activities. Apart from limiting the expression of IAP family proteins, curcumin promotes the apoptosis of cancer cells by increasing the expression of Bax while downregulating the expression of Bcl-2 in various cancer cells. It has also been shown to be able to abrogate angiogenesis elicited by breast tumors via the suppression of VEGF. Lately, curcumin has gained a great deal of interest, attributed to its broad range of medicinal properties. Intriguingly, curcumin exhibited countless anticancer properties, such as limiting cancer cell proliferation, promoting tumor cell death and preventing metastasis. Besides, curcumin supplementation greatly relieves the patients from experiencing adverse effects caused by conventional therapies. Hence, these properties pose great advantages to the development of curcumin combination therapy for cancer treatment. This review focuses on the use of curcumin in combination therapy in various cancers. The evasive mechanisms developed by cancer cells in response to cancer therapy are discussed. Curcumin combination therapies used are reviewed in depth in each type of cancer in both preclinical and clinical studies. We also addressed how curcumin modulates a variety of molecular targets in cancer cells in the combination treatment, to provide an insight into the multitargeting effects of such treatment cocktails.

Curcumin inhibits ovarian cancer progression
Journal of Ovarian Research | November 2021
Curcumin is the active component of turmeric which has an anti-cancerous property in multiple cancers, including ovarian cancer. It can exhibit the anti-cancer role in ovarian cancer by decreasing tumorigenesis and increasing the efficiency of radio-chemotherapy. Curcumin suppressed ovarian cancer cell proliferation and promoted apoptosis. Circ-PLEKHM3 was downregulated in ovarian cancer, and its expression could be promoted by curcumin treatment. Circ-PLEKHM3 overexpression exacerbated the effect of curcumin on ovarian cancer cell proliferation and apoptosis, as well as anti-tumor effect. MiR-320a was targeted by circ-PLEKHM3. The inhibition effect of circ-PLEKHM3 overexpression on cell proliferation and the enhancing effect on cell apoptosis could be reversed by miR-320a mimic. SMG1 was targeted by miR-320a, and its knockdown also reversed the regulation of miR-320a inhibitor on the proliferation and apoptosis of ovarian cancer cells. In addition, circ-PLEKHM3 could upregulate SMG1 expression via sponging miR-320a.

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases
Drug Design, Development and Therapy | November 2021
Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it. The anti-inflammatory effect of curcumin can effectively improve the symptoms of these diseases and is expected to be a candidate drug for the treatment of related diseases.  Curcumin has anti-inflammatory, anti-oxidant, anti-tumor and other biological activities. The anti-inflammatory properties of curcumin are considered to be the basis of its various biological activities and play an important role in the treatment of diseases. Curcumin is mainly derived from the root tuber of Curcuma aromatica Salisb and the rhizome of C. longa L. (Turmeric) of Zingiberaceae. Turmeric is a common spice in India and has been described in Ayurveda, as a treatment for inflammatory diseases. In western herbalism, turmeric is primarily used as an anti-inflammatory agent.3 Curcumin and curcuminoids, the active components of turmeric, are found as effective therapies over the years. Curcumin, demethoxycurcumin and bisdemethoxycurcumin, these three compounds are called curcuminoids. In addition, curcumin-containing dietary supplements are extremely popular, and there are many anti-oxidant and anti-inflammatory curcumin dietary supplements on the market.In conclusion, curcumin has good anti-inflammatory properties, and curcumin regulates NF-κB, MAPK, AP-1, JAK/STAT and other signaling pathways, and inhibiting the production of inflammatory mediators. Curcumin in the treatment of IBD, arthritis, psoriasis, depression and atherosclerosis and other diseases, can reduce inflammatory response, effectively improve symptoms, play a role in the treatment of diseases. Now, the pharmacokinetics and anti-inflammatory effects of curcumin have been improved to some extent by the structural modification and modification of curcumin, preparation research and drug combination therapy. Among them, curcumin dietary supplement or adjuvant drug has significant therapeutic effect, which is the most feasible way for curcumin application at present.

Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19
Frontiers in Pharmacology | November 2021
Patients with mild, moderate, and severe symptoms who received curcumin/piperine treatment showed early symptomatic recovery (fever, cough, sore throat, and breathlessness), less deterioration, fewer red flag signs, better ability to maintain oxygen saturation above 94% on room air, and better clinical outcomes compared to patients of the control group. Patients received curcumin-piperine capsules (three capsules/day; each capsules containing 500 mg curcumin plus 5 mg piperine; in total 1500 mg curcumin and 15 mg piperine/daily). Furthermore, curcumin/piperine treatment appeared to reduce the duration of hospitalization in patients with moderate to severe symptoms, and fewer deaths were observed in the curcumin/piperine treatment group.  Administration of oral curcumin with piperine as an adjuvant symptomatic therapy in COVID-19 treatment could substantially reduce morbidity and mortality, and ease the logistical and supply-related burdens on the healthcare system. Curcumin could be a safe and natural therapeutic option to prevent Post-Covid thromboembolic events. Orally administered curcumin with piperine could play a multifaceted role in the treatment of COVID-19. The anti-inflammatory and anti-thrombotic properties of curcumin could expedite the recovery of COVID-19 patients, and its antiviral, antibacterial, and antifungal properties could prevent superadded or secondary infections. Our results suggest that the use of orally administered curcumin with piperine as adjuvant therapy in COVID-19 treatment could substantially reduce morbidity and mortality, reduces treatment costs, and decrease logistical burden healthcare systems. Dose-escalating studies have indicated the safety of curcumin over 3 months. Hence, Curcumin can be a safe and natural therapeutic option to prevent Post-Covid thromboembolic events.

Curcumin induces apoptosis through caspase dependent pathway in human colon carcinoma cells
Molecular Biology Reports | November 2021
We investigated the apoptotic effects of curcumin in the colon carcinoma cell line SW480.  The proportion of BrdU-stained cells in the control groups were 58%, 57% and 61% and 28%, 27%, and 30% in the curcumin treatment groups at 24, 48, and 72 h, respectively. The proportion of apoptotic cells was 28%, 29%, and 28% in the control groups and 59%, 61%, and 60% in the curcumin treatment groups at 24, 48, and 72 h, respectively. As expected, caspase-3 staining also revealed a higher number of apoptotic cells in curcumin treatment groups at 24, 48, and 72 h compared to controls. These results suggest that curcumin may be a potential protective or treatment agent against colon cancer.

The emerging role of curcumin for improving vascular dysfunction
 Critical Reviews in Food Science and Nutrition | November 2021
Clinical intervention studies with curcumin have demonstrated significant improvements in endothelial function, arterial compliance, arterial stiffness, and other measures of vascular hemodynamics in young, middle-aged, old, post-menopausal, healthy, diabetic, and obese individuals. Mechanistically, curcumin is believed to improve vascular function through its effects on inflammation, oxidative stress, nitric oxide bioavailability, and structural proteins of the artery. Current data give support for curcumin to be administered for improvements in vascular health to individuals that may or may not be at risk for cardiovascular disease. This review briefly summarizes the techniques used for the establishment of vascular health and overviews the literature investigating the role of curcumin in the improvement of vascular health.

Curcumin enhances drug sensitivity of gemcitabine-resistant lung cancer cells and inhibits metastasis
Pharmazie International Journal of Pharmaceutical Sciences | November 2021
This study aimed to investigate the effects of curcumin on the proliferation, migration, and invasion of gemcitabine (GEM) resistant lung cancer A549 cells (A549/GEM), and the potential mechanism.  Curcumin and GEM can improve the sensitivity of A549/GEM to the GEM. Compared with the GEM, GEM plus curcumin significantly decreased the migration and invasion of A549/GEM cells. The expression levels of MMP9 , Vimentin, and N-cadherin were significantly decreased, while the E-cadherin expression was increased. In vivo experiments showed a better therapeutic effect of GEM combined with curcumin than that of GEM alone, and the combination therapy did not cause more toxicity to animals. In summary, curcumin reversed GEM resistance and inhibited the EMT process in A549/GEM cells. GEM, combined with curcumin, is safe and more effective in the treatment of non-small cell lung cancer.

Curcumin and Piperine in COVID-19: A Promising Duo to the Rescue?
Biomarkers, New Treatments, and Vaccines for COVID-19 | October 2021
The combination of curcumin and piperine is a potential option for the management of COVID-19 based on several mechanisms including antiviral, anti-inflammatory, immunomodulatory, antifibrotic, and antioxidant effects. Here, we describe the probable mechanism of curcumin-piperine against COVID-19. Administration of curcumin-piperine combination appears as a potential strategy to counterbalance the pathophysiological features of COVID-19 including inflammation.

Curcumin for Parkinson's disease
Cellular and Molecular Biology | October 2021
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders worldwide. Curcumin represents a promising bioactive compound with high therapeutic potential. Diverse studies in cellular and animal models have suggested that curcumin could be employed for the treatment of PD.

Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases
Phytotherapy Research | October 2021
Curcumin, a natural compound extracted from the rhizomes of Curcuma longa, has been under intense scrutiny for its wide medicinal and biological properties. Curcumin is known to manifest antibacterial, antiinflammatory, antioxidant, antifungal, antineoplastic, antifungal, and proapoptotic effects. A plethora of literature has already established the immense promise of curcuminoids in the treatment and clinical management of various chronic diseases like cancer, cardiovascular, metabolic, neurological, inflammatory, and infectious diseases. To date, more than 230 clinical trials have opened investigations to understand the pharmacological aspects of curcumin in human systems.

Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
Frontiers in Oncology | October 2021
Along with direct anticancer activity, curcumin hinders the onset of chemoresistance. Among many, high glucose condition is a key driving factor for chemoresistance. Curcumin obviated the hyperglycemia-induced modulations like elevated glucose consumption, lactate production, and extracellular acidification, and diminished nitric oxide and reactive oxygen species (ROS) production. Modulated molecular regulators are suggested to play a crucial role as curcumin pretreatment also prevented the onset of chemoresistance by high glucose. Curcumin alleviated the suppression of drug retention and nuclear condensation along with hindering the high glucose-induced alterations in transcription factors and signal transducers. Curcumin inhibited the elevated expression of these enzymes, transporters, and receptors in cancer cells. Curcumin also uplifted the SDH expression, which was inhibited in high glucose condition. Taken together, the findings of the present investigation first time demonstrate the ability of curcumin against high glucose-induced chemoresistance, along with its molecular mechanism. This will have implication in therapeutic management of malignancies in diabetic conditions.

The effects of curcumin supplementation on muscle damage, oxidative stress, and inflammatory markers in healthy females
International Journal of Preventive Medicine | October 2021
Given the reports of positive effects attributed to curcumin, many studies have investigated the antioxidant and antiinflammatory properties of curcumin. A previous report by Sahin et al. declared that curcumin administration can decrease muscle damage by regulating the nuclear factor-kappa B (NF-κB) in male Wister rats. In addition, the results of another study that performed on 90 rats with poly cystic ovarian syndrome (PCOS) showed a significant reduction in C-reactive protein (CRP) levels in the curcumin-treated rats. In healthy young adult women, 8 weeks of curcumin supplementation yielded significant improvements in CRP, LDH, MDA, and VO2 max. In the present study, we found that 8 weeks of curcumin administration attenuates MDA in females with moderate activity. In agreement with these findings, a previous study revealed that curcumin (1000 mg/day co-administered with piperine 10 mg/day) supplementation for 8 weeks led to a significant decrease in serum MDA and increase TAC in subjects with type 2 diabetes mellitus. Concordantly, 6-week supplementation of 1500 mg/day curcumin elicited significant improvements in antioxidant status and a significant decrease in MDA concentrations in patients with knee osteoarthritis. Curcumin, as an antioxidant agent, can increase superoxide dismutase level via inhibiting ROS-generating enzymes. In addition, it can increase serum activities of antioxidants. Another positive action of curcumin is related to scavenging properties to decrease oxidative damage.

Curcumin as a great contributor for the treatment and mitigation of colorectal cancer
Experimental Gerontology | October 2021
This review mainly brings out the correlation between the curcumin and its use for the mitigation of colorectal cancer, the use of curcumin as a chemotherapeutic agent, chemosensitizer, and in a combination and synergistic approach. The pharmacokinetics and pharmacodynamics properties of curcumin and its formulation approach helps in giving an idea to develop new approaches for the treatment of colorectal cancer using curcumin.

Curcumin induces apoptosis and autophagy in human renal carcinoma cells
Bioengineered | October 2021
Curcumin is a traditional Chinese herb that has been used for the treatment of various diseases. The compound has been particularly confirmed to have anti-inflammatory, anti-cancer, anti-virus, and anti-oxidant activities. Curcumin shows less side effects, hence appropriate as a novel anticancer drug. Previous studies have shown that curcumin administration inhibited the growth, formation, invasion, and proliferation of prostate cancer. Curcumin induces apoptosis of RCC through AKT/mTOR pathway inhibition, suppresses the TNF-a, IL6 and IL-8 pro-inflammatory cytokines. Further, curcumin down-regulates Akt/mTOR through upregulation of autophagy and finally, curcumin inhibits tumor weight and volume in vivo. Use of curcumin to target AKT/mTOR pathway could be an effective treatment alternative for renal cell carcinoma.

Curcumin attenuates spatial memory impairment by anti-oxidative, anti-apoptosis, and anti-inflammatory mechanism
NeuroToxicology | October 2021
Curcumin treatment improves spatial memory impairment after methamphetamine neurotoxicity. Curcumin treatment has an antioxidant activity in methamphetamine neurotoxicity. Curcumin treatment reduced caspase-3 activation after methamphetamine neurotoxicity. Curcumin treatment has an anti-inflammatory activity in methamphetamine neurotoxicity via reducing of TNFα. Curcumin treatment reduced astrogliosis after methamphetamine neurotoxicity.

Curcumin supplementation in the treatment of patients with cancer: a systematic review
Brazilian Journal of Pharmaceutical Sciences | October 2021
Curcumin is a long-used phytochemical with a large number of biological targets, for which anti-inflammatory, antioxidant, anti-tumor, immunoregulatory, hepatoprotective, anti-ischemic, anti-dyspeptic, anti-depressant, and analgesic effects have been determined (Amalraj et al., 2017). Preclinical studies have reported curcumin as a potent epigenetic regulator, acting in the inhibition of deoxyribonucleic acid (DNA), DNA methyltransferases (DNMTs), regulation of modifications of histone acetyltransferases (HATs) and deacetylases (HDACs) and in regulation of micro ribonucleic acids (miRNA) (Boyanapalli et al., 2015; Remely et al., 2015). Studies conducted in vitro show that curcumin prevents the degradation of nuclear factor erythroid 2-related factor 2 (Nrf2), leading to an increase in antioxidant enzymes such as superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx). In addition, it balances the level of these enzymes and recovers reactive oxygen species (Rezaee et al., 2017; Sahebkar, 2013). It was also shown to have an anti-inflammatory effect through negative regulation of several cytokines, such as tumor necrosis factor alpha (TNF-α), interleukins (IL-1, IL-6, IL-8, IL-12), monocyte chemoattractant protein-1, cyclooxygenase-2 activity (COX-2), lipoxygenase enzyme and inducible nitric oxide synthase (iNOS) (Aggarwal et al., 2007; Gupta et al., 2013). In vitro and in vivo investigations have also shown that curcumin reduces the inflammatory process by means of inflammatory transcription factors such as nuclear factor kappa (NF-kB), activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) (Panda et al., 2017; Imran et al., 2016). NF-ĸB and AP-1 also act as transcription factors that regulate the expression of different genes which affect cellular processes, such as proliferation and apoptosis. Curcumin also inhibited the expression of urokinase plasminogen (uPA), focal adhesion kinase activity (FAK), suppressed expression of matrix metalloproteinases (MMPs), inhibited epidermal growth factor receptor (EGFR) activity, regulating tumor cell invasion and metastasis (Durgaprasad et al., 2005; Vadhan-Raj et al., 2007; Kim et al., 2011; Belcaro et al., 2010; Shokes et al., 2005; Adhvaryu et al., 2008; Biswas et al., 2010). Due to these therapeutic properties, curcumin exhibited activities against various types of cancer (Gupta et al., 2013; Dhillon et al., 2008; Golombick et al., 2009; Ide et al., 2010).  The results of this study are based on those obtained in the literature on the effect of curcumin on the anti-inflammatory profile, on reducing dermatitis, on PSA alteration and on anti-oxidant profile for a total of 450 individuals, comprising 259 in the intervention group and 191 in the control group. Some studies have reported improvement in biochemical and clinical indicators, with limited adverse effects and good tolerance.

The clinical use of curcumin on neurological disorders: An updated systematic review of clinical trials
Phytotherapy Research | October 2021
Neuroprotective effects of curcumin have been shown in previous studies. This updated systematic review of clinical trials aimed to investigate the effect of curcumin on neurological disorders. Databases including PubMed, Scopus, Web of Science, and Google Scholar were systematically searched to identify clinical trials investigating the effects of curcumin/turmeric supplements alone, or in combination with other ingredients, on neurological diseases. Nineteen studies comprising 1,130 patients met the inclusion criteria. Generally, intervention and study outcomes were heterogeneous. In most of the studies, curcumin had a favorable effect on oxidative stress and inflammation. However, with the exception of AD, curcumin supplementation either alone, or in combination with other ingredients, had beneficial effects on clinical outcomes for the other aforementioned neurodegenerative diseases. For example, the frequency, severity, and duration of migraine attacks, scores on the revised ALS functional rating scale, and the occurrence of motor complications in PD were all significantly improved with curcumin supplementation either alone or in combination with other ingredients.

Curcumin exhibited better potential inhibition than Hydroxy-Chloroquine against COVID-19
Biological and Medicinal Chemistry | October 2021
According to present research results, Quercetin, Hispidulin, Cirsimaritin, Sulfasalazine, Artemisin and Curcumin exhibited better potential inhibition than Hydroxy-Chloroquine against COVID-19 main protease active site and ACE2.

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy
Basic & Clinical Pharmacology & Toxicology | October 2021
Curcumin (which originates from turmeric) is a hydrophobic polyphenol. It is one of the most famous anticancer and anti-inflammatory herbal agents. Traditionally, curcumin was used for some diseases such as acne and some inflammation-related diseases like arthritis.  Today, we know that curcumin has antioxidant and anti-inflammatory effects, which cause beneficial effects on the cardiac and neural systems and also has pharmacological effects on some diseases such as diabetes, Alzheimer, atherosclerosis, some immune system diseases and cancer. Curcumin has shown anticancer properties for several types of malignancies in both in vitro and in vivo studies. Gastrointestinal system malignancies, lung cancer, brain cancer cells, leukaemia, melanoma and renal, breast, prostate and pancreas cancers are some examples of inhibition of cancers by curcumin. Curcumin has also been shown to amplify the anticancer effects of chemotherapy drugs and radiotherapy. Although several agents may increase the therapeutic response of cancer cells to therapy, curcumin has shown interesting results for the protection of normal cells/tissues, a property that can reduce side effects of cancer therapy. Curcumin has been shown to protect several organs such as the lung, gastrointestinal system, heart, liver, testis, bone marrow and skin against the toxic effects of radiotherapy and chemotherapy. Curcumin as a natural agent has shown interesting anticancer properties. It can prevent genomic instability in normal cells to prevent the development of cancer. Furthermore, it can suppress tumour growth at different stages through induction of cell death, suppression of cancer cells' migration, angiogenesis, and others. In this review, we focused on the mechanisms of cell death induction in tumours using curcumin.  Curcumin is one of the most common herbal agents that has shown several anticancer properties. It can regulate immune system responses against cancer. Furthermore, curcumin has been shown to potentiate cell death signalling pathways and attenuate survival signalling pathways in cancer cells. The knowledge of how curcumin induces cell death in cancers can improve therapeutic efficiency. In this review, the regulatory effects of curcumin on different cell death mechanisms and their signalling pathways will be discussed. Furthermore, we explain how curcumin may potentiate the anticancer effects of other drugs or radiotherapy through modulation of apoptosis, mitotic catastrophe, senescence, autophagy and ferroptosis.

The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases
Neuroimmunomodulation | October 2021
Curcumin is the main component of a yellow pigment, commonly called diferuloylmethane, and is an active ingredient in the rhizome of the herb Curcuma longa that represents various biomedical applications. Curcumin has also been traditionally used for its medicinal benefits and wound healing for centuries. It was first applied as a drug to treat biliary disease in 1937. Curcumin is a lipophilic polyphenol that is relatively stable in the acidic pH but decomposes in neutral-basic conditions. Curcumin contains approximately 77% diferuloylmethane, 17% dimethoxycurcumin, and 6% bisdemethoxycurcumin. Nowadays, curcumin (C21H20O6) has important roles in the attenuation of progression of some neurodegenerative diseases because of its anti-amyloid and anti-inflammatory agents. In addition, curcumin also has several benefits, such as being safe, inexpensive, and readily available polyphenol that can cross the blood-brain barrier, thus attracting researchers to use it for treating neurodegenerative diseases. Curcumin is an NF-κB inhibitor by interrupting ZO-1 expression and localization, MLC phosphorylation, and ROS generation inhibition, which constrains disruption of the blood-brain barrierby Th17 cells. Furthermore, curcumin, through its NF-κB inhibitory effect, causes intestine dendritic cell differentiation into tolerogenic phenotypes, as well as naive T cells to differentiate into FoxP3+ regulatory T cells (intestine protective, Treg). Thus, curcumin can prevent colitis, due to its anti-inflammatory function.  The pharmacological activities of curcumin are antimicrobial, anti-inflammatory, antioxidant, and anticarcinogenic. It also exhibits potent immunoregulatory activities that can modulate the T cells, B cells, neutrophils, natural killer cells, and macrophage activation and function. Curcumin has been shown to be protective for several cells, including astrocytes, neurons, microglia, and different part of the CNS such as hippocampal, mesencephalic, cortical, and spinal cord. An MS animal study showed that curcumin regulates T-cell responses to IL-12 by blocking IL-12 production, and IL-12 signaling, through inhibiting JAK-STAT signaling activation. Thus, it has been suggested that curcumin could be used for treating MS and other Th1-cell-mediated inflammatory diseases. Furthermore, curcumin at high doses can directly induce T-cell apoptosis and inhibit T-cell proliferation through blocking of the IL-2 signaling pathway, high-affinity IL-2R, and interfering with IL-2R signaling. These data indicate that curcumin has immunosuppressive effects on many pathways. Thus, curcumin, through its proinflammatory cytokines, decreases TNF-α/β, IL-1, IL-6, and IL-8, and COX-2 provides a therapeutic effect by reducing inflammatory conditions. Curcumin can cross blood-brain barrier and, by inhibiting proinflammatory cytokines, can regulate homeostasis of the CNS. The blood-brain barrier has a crucial role in controlling the homeostasis of the brain microenvironment. Thus, because autoreactive T-cell penetration plays a key role in MS lesion development, the role of curcumin to protect the blood-brain barrier could reduce the severity of MS. Curcumin also decreases the severity of chronic inflammatory diseases, such as rheumatoid arthritis, asthma, AD, and cancer. In phase II clinical trial, curcumin was used orally in a mouse model of colorectal cancer. It has been demonstrated that curcumin can prevent carcinogenesis through different mechanisms such as reduction of cyclooxygenases 1 and 2, 5-lipoxygenase, prostaglandin E2 (PGE2), and 5-hydroxyeicosatetraenoic acid production inhibition. Fortunately, curcumin via inhibition of NF-κB signaling pathways can improve the effects of some chemotherapy drugs. For example, in the mouse model of human breast cancer, curcumin, in conjunction with paclitaxel, can slow breast cancer progression and metastasis to the lung. Unfortunately, curcumin has several disadvantages in cancer treatment, including inhibition of some chemotherapy drug activities. For example, curcumin decreased camptothecin-induced death in cultured breast cancer cells and inhibited breast tumor regression in mice. Furthermore, curcumin can also interfere with colon cancer treatment through the change in irinotecan absorption and efficacy. Curcumin is a valuable ingredient present in turmeric spice and has several essential roles, including those which are anticarcinogenic, hepatoprotective, thrombosuppressive, cardioprotective, anti-arthritic, anti-inflammatory, antioxidant, chemopreventive, chemotherapeutic, and anti-infectious. Furthermore, curcumin can suppress inflammation; promote angiogenesis; and treat diabetes, pulmonary problems, and neurological dysfunction.

Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential
Biomedicine & Pharmacotherapy | October 2021
The chemical structure of curcumin known as diferuloylmethane has been elucidated in 1910, the first study on its biological activity as an antibacterial agent according to the PubMed database has been published in 1949 Nature journal and the first clinical trial has been reported in 1937 Lancet journal. Until now, there are numerous in vitro, in vivo, and clinical studies that show it contained antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, and anti-viral infection. The major constituents of curcuminoids contain Dihydrocurcumin, Tetrahydrocurcumin, Curcumin, Bis-demethoxycurcumin, and Demethoxycurcumin from turmeric (C. longa L.) rhizome. The beneficial health properties and medicinal values of curcumin include its effect on immune modulation, cardiovascular protection, and neuroprotection.  Previous report, the potential of turmeric as an antimicrobial, insecticidal, larvicidal, antimutagenic, radioprotector, and anticancer agent have validated in cell-based studies. Numerous animal studies have found the latent of turmeric against proinflammatory diseases, obesity, diabetes, atherosclerosis, cancer, depression, and neurodegenerative diseases. Moreover, turmeric has shown efficacy against numerous human disorders including lupus nephritis, irritable bowel syndrome, acne, fibrosis, diabetes, and cancer in clinical trial. Of note, curcumin, major component of turmeric, is widely studied at the preclinical level in various chronic illnesses that have been extensively reviewed in many papers including mechanistic insights . Of note curcumin is an important active ingredient in turmeric that exerts pharmacological effects. Current research has demonstrated that the pharmacological effects of curcumin include: anti-lipidemics, anti-diabetics, anti-tumor, anti-inflammatory, anti-fibrosis, anti-virus, anti-oxidation, and serve as free radical scavengers.

Curcumin suppresses the progression of gastric cancer
Open Life Sciences | October 2021
Curcumin is a natural polyphenolic compound isolated from turmeric, which has lipid-lowering, anti-tumor, anti-inflammation, and anti-oxidation effects. Recently, studies have shown that curcumin can reduce the malignancy of several cancers, such as pancreatic cancer, retinoblastoma, osteosarcoma, and bladder cancer. Moreover, curcumin has also been reported to have an anti-tumor effect on gastric cancer. Nonetheless, the role and underlying mechanism of curcumin in gastric cancer have not been well recognized.  We discovered that curcumin was able to inhibit gastric cancer cell growth and motility and induce apoptosis by suppressing circ_0056618 and elevating miR-194-5p. Previous research have verified that curcumin exerts the anti-tumor effect mainly by repressing tumor cell proliferation and motility and facilitating apoptosis. For example, curcumin treatment restrained Rb cell proliferation, invasion, and migration and accelerated apoptosis. Curcumin suppressed the growth and cell cycle process and facilitated the apoptosis of gastric cancer cells. In line with these reports, we demonstrated that curcumin treatment restrained cell colony formation, migration, and invasion and accelerated cell cycle arrest and apoptosis in gastric cancer cells in vitro and blocked tumorigenesis of gastric cancer in vivo, indicating that curcumin might be a candidate agent for gastric cancer therapy.  In summary, curcumin treatment could repress gastric cancer cell growth and metastasis and promote apoptosis partly by regulation of circ_0056618/miR-194-5p axis. The findings facilitated our understanding on the mechanism of curcumin in gastric cancer therapy and indicated that curcumin might be a potential therapeutic drug for gastric cancer . In addition, accumulating evidence showed that curcumin might prevent gastric cancer through regulation of oncogenic pathways.

The Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study
Drug Design, Development and Therapy | October 2021
Curcumin, the major active component of Curcuma longa, was first isolated in 1870 and widely used as spice, flavor, and colorant in daily life.12 Several studies have evidenced the antioxidant, anti-inflammatory, anticarcinogenic, cardioprotective and nephroprotective effects of curcumin. The protective effects of curcumin on AKI are generally associated with its bifunctional antioxidant activity and anti-inflammatory activity Curcumin could ameliorate kidney disease with either acute or chronic nephritis, and reduce activation of the NF-κB, MAPK, AKT and pBAD pathways either systemically, or within the inflamed kidneys. In addition, previous research found that curcumin could improve renal function during ischemia-reperfusion induced acute kidney injury, which protected the tubular epithelium from injury by modulating inflammatory processes, oxidative stress, and apoptosis. In our study, we show that curcumin represents a new and promising effective treatment in S-AKI rat models. Treatment with curcumin ameliorates renal functions, improves both renal macro- and microcirculatory flow, reduces inflammatory response and prevents pathological changes in kidney.  Curcumin may be a potential novel therapeutic agent for the prevention or reduction of S-AKI.

Curcumin Reduces Adipose Tissue Inflammation and Alters Gut Microbiota in Diet-Induced Obese Male Mice
Molecuar Nutrtion and Food Research | October 2021
Curcumin exerts protective metabolic effects in dietary obesity, in part through downregulation of adipose tissue inflammation, which may be mediated by alterations in composition of gut microbiota, and metabolism of curcumin into curcumin-o- glucuronide.

New insights of structural activity relationship of curcumin and correlating their efficacy in anticancer studies
American Journal of Cancer Research | October 2021
During the process of carcinogenesis at multiple stages, curcumin is involved in several mechanisms including (a) the inhibition of tumor initiation (cytotoxic studies) (b) suppression of cellular proliferation (antiproliferation studies) (c) the induction of apoptosis (d) the inhibition of angionesis and metastasis (e) the inhibition of tumor induced immunosuppression. Analyzing the cytotoxic results, curcumin has shown its potency towards most of the cancer cell lines like Hela (Cervical cancer), HepG2 (Liver cancer), A549 (Adenocarcinoma human alveolar), MCF-7 and MDA-MB-231 (Breast cancer), PC-3, RWEP-1 and DU145 (Prostate cancer), SkoV3 (Ovarian cancer), A-431 (Epidermoid carcinoma), U-251, T98, U87, U87 MG and U87 GBM (Glioblastoma), Panc-1 and BxPC3 (Pancreatic cancer), HT-29 and HCT116 (Colon cancer), H1299 and H460 (Lung cancer), AGS (Gastric cancer), HCT-15 (Colorectal adenocarcinoma), K562 (Chronic myelogenous). Demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are naturally occurring compounds, which shows enhance potency against cancer cell lines in vitro and differ from curcumin in the position and number of hydroxyl and methoxy substitution pattern. The presence of methoxy and hydroxyl group in curcumin plays a vital role in deciding various biological activities as reported by various research groups. Curcumin is a naturally occurring compound which appears to be significant clinical for applications in vitro as well as in vivo studies. Many of the research groups have been paying attention towards natural products for the development of anticancer drugs. Curcumin, Rosmarinic acid and Chalcone are the naturally occurring compounds, which are chemopreventive and chemotherapeutic.

The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome
Phytotherapy Research | October 2021
Compared with the control group, curcumin was associated with a statistically significant improvement in the glycemic control including fasting blood glucose, insulin level, homeostasis model assessment of insulin resistance, and quantitative insulin sensitivity check index. The mean difference in total cholesterol was also statistically significant. This review concluded that among patients with PCOS, the use of curcumin demonstrated a significant difference from the control group for glycemic control. Those findings suggest that curcumin confers clinical benefits in patients with PCOS. 

Curcumin as an Adjuvant to Cancer Immunotherapy
Frontiers in Oncology | September 2021
Turmeric, a common spice obtained from Curcuma longa of the Zingiberacea (Ginger) plant family, is the natural source of curcuminoids, a mixture of three different components, i.e., curcumin, demethoxycurcumin, and bisdemethoxycurcumin. A major fraction of this compound mixture is curcumin or diferuloylmethane with 368.38 molecular weight. The crystalline orange-yellow powder is an active polyphenolic phytochemical and has been widely used in medicinal purposes for centuries in India and South Asia, due to its nontoxic but miraculous properties such as anti-oxidant, analgesic, antiseptic, anti-inflammatory, and anti-cancer activity.  Over time, curcumin has been considered as a potential anti-cancer molecule. Its potentialities have been recorded against the standard hallmarks of cancer such as continuous proliferation, escaping apoptosis, continuous angiogenesis, insensitivity to growth inhibitors, tissue invasion, and metastasis. Finally, the conclusion has been drawn with the application of curcumin as a potential immune-adjuvant, which fearlessly could be used with immunotherapies for best outcomes. Hence, it is considered very interesting to envision the role of curcumin concerning cancer immunotherapies as an immunomodulator.

Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-κB signalling pathway
Journal of Cellular and Molecular Medicine | September 2021
Curcumin, extracted from turmeric rhizomes, is a Food and Drug Administration-approved food additive in the curry spice turmeric. It possesses potent anti-inflammatory and antioxidant properties and is widely used to treat chronic inflammatory diseases, such as heart disease, cancer, metabolic syndrome and various other degenerative diseases.It has therapeutic potential in AD models, both in vitro and in vivo. Curcumin is a natural polyphenolic product derived from the rhizome of Curcuma longa and has various beneficial properties, such as anti-inflammatory, antioxidant and antitumor properties. Here, we found that curcumin treatment effectively improved the cognitive performance of transgenic mice in the MWM and Y-maze, and our results were consistent with those of previous studies. In conclusion, this study demonstrated that curcumin treatment significantly ameliorates cognitive impairment in aged APP/PS1 transgenic mice. The possible underlying mechanism might be associated with the accumulation of amyloid plaques, activation of the HMGB1-RAGE/TLR4-NF-κB signalling pathway, and astrocytes activated during neuroinflammation in APP/PS1 transgenic mice. These results suggest that curcumin treatment, as a food additive for long-term oral administration, is an effective therapeutic strategy for AD
.

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers
Frontiers in Pharmacology | September 2021
For centuries, curcumin has been widely used as a dietary spice, and contemporary research studies have confirmed its efficacy in cancer therapy. Anticancer effects are the most pivotal properties of curcumin, which affect the different stages of cancer progression, including cancer cell formation, proliferation, and tumor invasion. According to extensive research, curcumin can suppress metastasis in GI cancers via regulating various signaling pathways. Curcumin has a crucial function in metastasis prevention by several mechanisms, including preventing transcription factors as well as their signaling pathways (e.g., NF-κB, STAT3, AP-1), multiple proteases (e.g., MMPs, uPA), inflammatory cytokines (e.g., CXCL1, IL-6, CXCL2, IL-8), modulation of miRNAs (e.g., miR181b, miR21), multiple protein kinases (e.g., FAK, MAPKs), and heat shock proteins (HLJ1). According to research, curcumin treatment leads to significant elevation in metastatic tumor cross-sectional volume (70%) and zone (46%). Curcumin may enhance LLC's metastatic growth in mice by elevating the concentration of VEGF, angiogenic factors, monocyte chemotactic protein-1 (MCP-1), and IL-1β. In addition to the possible pharmaceutical effects of curcumin, the safety and relevant therapeutic dose should also be established, given reports on the side effects of curcumin in cancer therapy. Curcumin a polyphenolic extraction of Curcuma longa species, which is often termed as turmeric (Shafabakhsh et al., 2019; Ashrafizadeh et al., 2020). Curcumin had been used as a traditional Ayurvedic medicine due to its significant anti-inflammatory (Satoskar et al., 1986), antioxidant (Masuda et al., 2001), and antimicrobial (Negi et al., 1999) properties. Currently, curcumin is associated with powerful anticancer properties. Different animal studies have shown that curcumin has important roles in inhibiting primary tumorigenesis in numerous organs as metastatic sites, such as mammary glands (Inano et al., 1999) and gastrointestinal tract (Huang et al., 1994).It also diminished the vascular endothelial growth factor (VEGF) serum levels in mice models of hepatocellular carcinoma (Yoysungnoen et al., 2006).

Curcumin suppresses inflammatory signaling in brain microglia
The Journal of Immunology | September 2021
Curcumin is a major component of tumeric. It has been used as an Indian medicine for centuries, and is currently commonly used as a spice for flavor and to impart a yellow color. Curcumin has recently received much attention for its anti-inflammatory, antioxidant, and antitumor activities. The anti-inflammatory actions of curcumin seem to be closely related to the suppression of proinflammatory cytokines and mediators of their release such as TNF-γ, IL-1β, and NOs. There are reports that curcumin inhibits cytokine-mediated NF-κB activation by blocking a signal leading to I-κB kinase activity in intestinal epithelial and mouse fibroblast cells, and also suppresses phorbol ester-induced c-Jun/AP-1 activation. However, the mechanisms underlying interactions of curcumin with these signaling pathways are poorly understood. Recently, we have shown that JAK-STAT inflammatory signaling modulates glial activation. Thus, we examined whether curcumin inhibits the JAK-STAT pathways in activated microglia. Curcumin inhibits the phosphorylation of JAK1 and JAK2 via the increased phosphorylation of SHP-2 and its association with JAK1/2, thus attenuating inflammatory response. Our results show that curcumin acts via a novel anti-inflammatory mechanism and is also a negative regulator of the JAK-STAT pathway by the activation of SHP-2. Taken together, these data suggest curcumin suppresses JAK-STAT signaling via activation of SHP-2, thus attenuating inflammatory response of brain microglial cells.

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
Molecules | September 2021
Curcumin is a natural dietary polyphenol extracted from Curcuma longa Linn with different biological and pharmacological properties including antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephro-protective, hepato-protective, anti-neoplastic, anti-rheumatic, and anti-aging. The chemical name of curcumin is 1,7-bis(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione with a chemical formula of C12H20O6; it is formed by two aromatic rings with a methaxy phenolic group, kinked with a linear carbon chain, with an α,β-unsatured β-diketone moiety. Curcumin, like other polyphenols, has pleiotropic activity. Indeed, due to its capacity to interact with many proteins, curcumin can induce cellular response to external stimuli. Moreover, curcumin up- and downregulates different miRNA and takes part in epigenetic changes in cell.  In our view, curcumin is one of the best candidates to achieve this goal with its antiviral, antinociceptive, anti-inflammatory, antipyretic, and antifatigue proprieties. It is important to highlight that Curcumin is devoid of any significant toxicity in most of the preclinical as well as clinical investigations, and few investigations have reported negative effects of curcumin. In addition, natural products may be a safe, secure, and dependable source to find drugs responsible for controlling the current pandemic, and even if the beneficial effects of curcumin against SARS-CoV-2 have not yet been reported, curcumin has some useful clinical effects that could be effective to manage the symptoms of the infected patient with COVID-19. Curcumin in fact can modulate the events of SARS-CoV-2 cellular entry, their replication, and molecular cascade manifesting pathophysiological consequences of COVID-19. Due to its important and healthy proprieties, we think that dietary supplementation with curcumin could be a suitable approach to prevent a large panel of diseases and improve the quality of life. In this review, we have described the anti-aging potential of curcumin with particular regard to prevention and treatment of brain diseases, in different ways: (1) by acting on different target proteins, (2) by inducing antioxidant and anti-inflammatory events, (3) by modulating microglia neuroprotection, and (4) by acting on telomerases to arrest cancer progression.

Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and Slows In Vivo Growth of Liver Metastases in Rats
Biomedicines | September 2021
Curcumin has shown an anti-tumor effect against liver implants from colorectal cancer, both in vitro and in vivo, in this experimental model. Curcumin is a well-known plant-derived polyphenol with a wide range of activities, such as antibacterial, anti-inflammatory, and hepatoprotective properties. In vitro studies with several cancer cell lines have proven curcumin to inhibit proliferation, such as on MCF-7 human breast tumor cells. It has also been observed that curcumin can improve the efficacy of other therapies, such as Paclitaxel on rat glioma C6 cells, and of 5-FU and/or oxaliplatin in BGC-823 human gastric cancer cell line or in HCT116 human colon cancer cells. In this cell line, it has been found that curcumin inhibits the cell cycle, activates p53 (only in p53+/+ cells) and p21, and triggers cellular senescence (irreversible growth arrest of proliferating cells) through the activation of the lysosomal enzyme senescence-associated-β-galactosidase (SA-β-gal) and the upregulation of the p21 protein. Other studies have also shown that curcumin-induced apoptosis is related to oxidative stress caused by the production of superoxide anion, which contributes to p53-independent cellular cytotoxicity. These findings were further corroborated in other cell lines (COLO-205), showing that curcumin induces cytotoxicity and apoptosis in a dose-dependent manner. In addition, curcumin promotes the production of reactive oxygen species and Ca2+, and induces the caspase-3 activity. In in vivo animal studies using cancer cells implants (most of them in animals lacking immune system), curcumin reduces the growth of the implants and the appearance of metastases. It has also been demonstrated that curcumin reduces tumor invasion and metastatic growth by, for example, reducing the activity of matrix metalloproteinases (MMPs) 2 and 9, or blocking nuclear translocation of nuclear factor kappa B (NFκB) by inhibiting the inhibitor of kappaB kinase. This molecular pathway is also involved in the prevention of liver damage after exposure to radiotherapy by regulating oxidative stress damage and reducing the accumulation of reactive oxygen species, which are well known to contribute to tumor progression by promoting cell transformation, proliferation, and the survival of tumor cells.

Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment
Research in Veterinary Science | September 2021
Curcumin prevented short and long-term memory deficits caused by doxorubicin.

The Influence of Turmeric and Curcumin on Female Reproductive Processes
Planta Medica | September 2021
The present review summarizes the available knowledge concerning the action of curcumin, the best-known polyphenol among the rhizomes of Curcumas, on female reproductive processes and their dysfunctions. Curcumin affects a number of physiological processes, including female reproduction (puberty, reproductive aging, ovarian follicullogenesis and oogenesis, and fecundity). Curcumin can affect these processes via changes in the release and reception of pituitary and ovarian hormones, growth factors and cytokines. Furthermore, it can influence the response of ovarian cells to these substances and external environmental factors. Finally, curcumin can affect oxidative processes within the ovary and numerous intracellular signalling pathways related to ovarian cell proliferation and apoptosis. These effects suggest the applicability of curcumin for stimulation of female reproductive processes in vivo and in vitro, as well as for the prevention, mitigation, and treatment of various reproductive disorders from ovarian insufficiency and infertility to polycystic ovarian syndrome and ovarian cancer.

Curcumin Inhibits Replication of Human Parainfluenza Virus
BioMed Research International | September 2021
Curcumin is a natural phenolic compound extracted from a plant turmeric rhizome. It has a wide range of anti-inflammatory, antioxidant, and antitumor properties. Recent studies have found that curcumin has broad-spectrum antiviral capabilities. Here, we identify a novel role for curcumin as an antiviral drug against HPIV3 infection through its ability to affect IB formation and viral replication. This provides a theoretical basis for research and development of HPIV3 antiviral drugs, with implications for parainfluenza virus research and other similar viruses. Our studies found that curcumin has a significant antiviral effect on HPIV3 infection and has varying degrees of impact on multiple stages of the viral life cycle. Curcumin can disrupt the structural integrity of F-actin, downregulate the endogenous PI4KB expression, and interfere with the colocalization of PI4KB and IBs, thereby hindering viral IB formation and inhibiting viral replication. Mazumder discovered that curcumin could inhibit HIV-1 integrase, thereby inhibiting HIV-1 infection, and inhibit HCV replication by interfering with the Akt-SREBP-1 pathway. Curcumin can also interfere with binding of Zika and Chikungunya viruses to host cells to inhibit viral infection. To inhibit hepatitis B virus, curcumin can downregulate the metabolic molecule PGC-1. Although curcumin pretreatment does not affect plaque formation of enterovirus 71 (EV71), curcumin downregulates PI4KB expression in cells and affects the in vitro replication of EV71. Several studies have shown that curcumin has antiviral ability against enveloped and nonenveloped viruses, and the antiviral mechanisms in different viruses are also diverse.

Turmeric and Curcumin: From Traditional to Modern Medicine
Studies on Biomarkers and New Targets in Aging Research | September 2021
The rhizome of turmeric (Curcuma longa L.) has been used as an herbal medicine, coloring agent, spice, and food additive for thousands of years in different parts of the world particularly in Asian countries. It has been used for a range of diseases in many traditional medical schools, including Islamic traditional medicine, Chinese traditional medicine, and Ayurveda. It has been used mainly for digestive problems, as a cardio-, hepato-, and neuroprotective agent as well as in many inflammatory conditions such as arthritis and for enhancing immune system. Curcumin, a diarylheptanoid derivative found in turmeric, has anti-inflammatory, antioxidant, and anticancer properties; controls obesity and metabolic problems; and improves memory and mood disorders. These findings emphasize that most of the traditional applications of turmeric is due to the presence of its key constituent, curcumin. According to the traditional background of turmeric use and clinical values of curcumin, further preclinical studies for unstudied properties and clinical studies with larger sample sizes for confirmed activities are expected.

Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus
Evidence-Based Complementary and Alternative Medicine | September 2021
Curcumin is a chemical component extracted from the rhizome of some plants. It has a series of effects such as blood lipid lowering, antitumor, anti-inflammatory, and antioxidation and has been used as a food flavoring agent, preservative, and ancillary medication for some diseases (such as heart disease and tumors). In the treatment of diabetes, there is also evidence to support curcumin as a part of the diabetes treatment program. Based on the current evidence, curcumin may assist in improving insulin resistance, glycemic control, and decrease in TG and TC in patients with T2DM.

Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury
Environmental Toxicology | September 2021
As a plant polyphenol, curcumin is the most vital bioactive ingredient of turmeric and has a wide range of pharmacological activities. In the present study, we investigated the potential roles of curcumin against arsenic-induced liver and kidney dysfunctions in mice. Curcumin treatment (200 mg/kg) not only decreased the deposition of arsenic in liver and kidney, but also relieved the hepatic and nephritic biochemical indexes (Glutamic oxaloacetic transaminase [AST], Alanine aminotransferase [ALT], albumin, and creatinine) altered by arsenic at doses of 10 and 25 mg/L via drinking water. What's more, curcumin exerted influences on the activities of myeloperoxidase and on the secretion of inflammatory cytokines in liver and kidney tissues. In addition, the levels of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB) phosphorylation were declining while NRF2-signaling targets were increasing in mice liver and kidney by curcumin administration. In conclusion, our results here suggest that curcumin could exert both anti-inflammatory and antioxidant functions on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-κB and activating Nrf2 pathways cooperatively.

Anti-Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction
Mediators of Inflammation | September 2021
Curcumin, an active ingredient extracted from natural plants, has been proven to have many physiological effects, including hypolipidemic, antitumor, anti-inflammatory, and antioxidation, and was used as treatment for drug-resistant tuberculosis, etc. Importantly, previous studies have shown that curcumin promotes heart repair after myocardial infarction and improves cardiac dysfunction, as well as improving the therapeutic efficacy of heart failure after myocardial infarction, but the specific mechanism is imperfect. In addition, curcumin has been found to suppress inflammation by inhibiting macrophage infiltration, and it can also regulate macrophage polarization. In this study, we found that curcumin not only attenuated ventricular remodeling and inflammation after MI but also reduced M1 but increased M2 macrophage activation in the MI mouse model. In addition, in vitro studies also revealed that some curcumin regulates the molecular mechanism of macrophage polarization, which was regulated AMPK expression. All in all, our research enriches the mechanism of curcumin in the treatment of myocardial infarction.

Effects of Curcumin against Influenza Using In Silico and In Vitro Approaches
Pharmaceuticals | September 2021
Curcumin has attracted considerable research interest because of its versatile pharmacological properties, including anti-inflammatory, antiviral, and anticancer effects. Previous studies have reported that curcumin inhibits the influenza virus by interfering with cellular signaling pathways, including Toll-like receptor and nuclear factor-κB pathways, and disrupting the viral envelope and liposomal membranes.

Curcumin: Implications for the Treatment of Multiple Sclerosis
Studies on Biomarkers and New Targets in Aging Research | September 2021
Curcumin is the active component of turmeric and a phenolic phytochemical. This phytochemical has anti-inflammatory properties and has been shown by multiple studies to downregulate NF-κB and its downstream gene targets including cyclooxygenase-2, tumor necrosis factor-α, interleukin-1, and interleukin-6.

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers
Frontiers in Pharmacology | August 2021
For centuries, curcumin has been widely used as a dietary spice, and contemporary research studies have confirmed its efficacy in cancer therapy. Anticancer effects are the most pivotal properties of curcumin, which affect the different stages of cancer progression, including cancer cell formation, proliferation, and tumor invasion. According to extensive research, curcumin can suppress metastasis in GI cancers via regulating various signaling pathways. Curcumin has a crucial function in metastasis prevention by several mechanisms, including preventing transcription factors as well as their signaling pathways (e.g., NF-κB, STAT3, AP-1), multiple proteases (e.g., MMPs, uPA), inflammatory cytokines (e.g., CXCL1, IL-6, CXCL2, IL-8), modulation of miRNAs (e.g., miR181b, miR21), multiple protein kinases (e.g., FAK, MAPKs), and heat shock proteins (HLJ1). According to research, curcumin treatment leads to significant elevation in metastatic tumor cross-sectional volume (70%) and zone (46%). Curcumin may enhance LLC's metastatic growth in mice by elevating the concentration of VEGF, angiogenic factors, monocyte chemotactic protein-1 (MCP-1), and IL-1β.Curcumin or [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is a polyphenolic extraction of Curcuma longa species. Curcumin had been used as a traditional Ayurvedic medicine due to its significant anti-inflammatory (Satoskar et al., 1986), antioxidant (Masuda et al., 2001), and antimicrobial (Negi et al., 1999) properties. Currently, curcumin is associated with powerful anticancer properties. Different animal studies have shown that curcumin has important roles in inhibiting primary tumorigenesis in numerous organs as metastatic sites, such as mammary glands (Inano et al., 1999) and gastrointestinal tract (Huang et al., 1994). It also diminished the vascular endothelial growth factor (VEGF) serum levels in mice models of hepatocellular carcinoma (Yoysungnoen et al., 2006). Interleukin (IL)-1β and monocyte chemotactic protein-1 (MCP-1) are critical inflammatory cytokines in tumorigenesis. Accordingly, some studies demonstrated that these cytokines' expression levels reduced after curcumin intervention (Abe et al., 1999). Recent studies have also indicated that curcumin can modulate tumor immune responses and remodel the tumor immunosuppressive microenvironment, indicating its potential in the immunotherapy of cancer (Mukherjee et al., 2018; Bahrami et al., 2019a; Pan et al., 2019). Curcumin has antimetastatic activities, modulating T cells, B cells, macrophages, neutrophils, NK cells, dendritic cells and production of cytokines and chemokines. In addition, recent studies have shown that curcumin exerts immunosuppressive effects (Shafabakhsh et al., 2019). These findings showed that curcumin has crucial roles in the inhibition of angiogenesis and metastasis in GI cancers.

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
Molecules | August 2021
Curcumin is a natural dietary polyphenol extracted from Curcuma longa Linn with different biological and pharmacological properties including antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephro-protective, hepato-protective, anti-neoplastic, anti-rheumatic, and anti-aging. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain.

Antioxidant effects of curcumin and neuroaging
Factors Affecting Neurological Aging | August 2021
Curcumin, a plant-based polyphenol, is known to scavenge free radicals and promote antioxidant activity.  evidenced by brain imaging studies is reviewed. Although there are limited published clinical trials, there is preliminary evidence for curcumin improving memory and decreasing amyloid-β plaque accumulation. Consequently, curcumin has potential as a therapy in aging and aging-related disorders and further studies on its properties are warranted.

Pleiotropic nature of curcumin in strategies to treat gastric cancer
Phytotherapy Research | August 2021
Curcumin, isolated from the rhizomes of Curcuma longa L. has several medicinal properties like antiinflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic. Such pleiotropic nature of curcumin impedes the invasion and proliferation of GC by targeting several oncogenic factors like p23, human epidermal factor receptor2 including Helicobacter pylori. The side effect of chemotherapy, that is, chemotherapeutic resistance and radiotherapy could be reduced combination therapy of curcumin. Moreover, the photodynamic therapy of curcumin destroys the cancer cells without affecting normal cells.

Targeting of the tumor microenvironment by curcumin
BioFactors | August 2021
Curcumin is a plant-derived agent that has shown interesting properties for cancer therapy. It has shown that not only directly inhibit the growth of cancer cells, but can also modulate the growth and activity of immunosuppressant and tumor-promoting cells. In this review, we explain how curcumin modulates interactions within TME in favor of tumor treatment. The potential modulating effects of curcumin on the responses of cancer cells to treatment modalities such as immunotherapy will also be discussed.

Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials
Cytokine | August 2021
 Curcumin has the potential for lowering inflammation.  There was a significant decrease in the serum levels of IL-1 and TNF-α compared to the placebo group following treatment.  The dose-responses analysis indicated that curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration in a non-linear model.  Subgroup analysis according to duration and dose of treatment and target population revealed diverse outcomes. Curcumin could have a beneficial effect in reducing the proinflammatory cytokines IL-1 and TNF-α.

Antidiabetic Properties of Curcumin: Insights on New Mechanisms
Studies on Biomarkers and New Targets in Aging Research | August 2021
Curcumin, a bioactive polyphenol derived from Curcuma longa L., exhibits therapeutic effects against diabetes while only negligible adverse effects have been observed. Antioxidant and anti-inflammatory properties of curcumin are the main and well-recognized pharmacological effects that might explain its antidiabetic effects. Additionally, curcumin may regulate novel signaling molecules and enzymes involved in the pathophysiology of diabetes, including glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters, alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated receptor gamma (PPARγ). Recent findings from in vitro and in vivo studies on novel signaling pathways involved in the potential beneficial effects of curcumin for the treatment of diabetes are discussed in this review.

Curcumin: A Review of Its Effects on Epilepsy
Studies on Biomarkers and New Targets in Aging Research | August 2021
Curcumin (diferuloylmethane) is a major component of Curcuma longa and exhibits various pharmacological effects, including anti-inflammatory, antioxidant, and immunoregulatory properties. Here, we have reviewed the literature relating specifically to the antiepileptic effects of curcumin. The evidence suggests a protective effect of curcumin in the control of epileptic seizures, together with a protective effect on the relief of memory impairment, which may stem from its influence on monoamine levels in the brain.

Curcumin for the Treatment of Prostate Diseases: A Systematic Review of Clinical Trials
Studies on Biomarkers and New Targets in Aging Research | August 2021
Curcumin is a primary component of turmeric with several proven health benefits and is considered as a safe natural agent for both prevention and treatment of several diseases. It has been shown that this active compound of turmeric has several unique properties such as anti-tumour, anti-inflammatory, antioxidant, antithrombotic, chemosensitising and chemopreventive, anti-atherosclerotic and cardioprotective, lipid-modifying, antibacterial, antifungal, antiviral, analgesic, antidepressant and antirheumatic activities. Evidence suggests that curcumin has anticancer activity and, based on preclinical studies, it might be used to downregulate gene expression in prostate cancer cells. Also, due to the anti-inflammatory effects of curcumin, it has been suggested that this bioactive compound might have a beneficial impact on BPH and other inflammatory prostate conditions. The main finding of this systematic review is that curcumin supplementation alone or in combination with the other herbs had some favourable effects on prostate diseases without any considerable adverse effects.  In particular, curcumin appeared to have anti-inflammatory effects which could offer some therapeutic effects and improve patient outcomes.

The Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials
Studies on Biomarkers and New Targets in Aging Research | August 2021
Curcumin is one of the most studied hydrophobic polyphenols, derived mainly from Curcuma longa L. (turmeric). Curcumin has been widely and safely used in the treatment and prevention of various diseases. The potential protective mechanisms of curcumin have been claimed to be related to antioxidant, anti-inflammatory, anti-microbial, neuroprotective, anti-tumor, and immunomodulatory properties. Curcumin with anti-antioxidant, anti-inflammatory, and immunomodulatory properties might have beneficial effects on Rheumatoid Arthritis. Rheumatoid factor was significantly reduced after consumption of curcumin in all three relevant studies. None of the studies reported serious adverse effects with curcumin consumption. The present systematic review suggests that curcumin could be used as a safe agent to treat Rheumatoid Arthritis.

Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials
Cytokine | August 2021
Curcumin has the potential for lowering inflammation. There was a significant decrease in the serum levels of IL-1 and TNF-α compared to the placebo group following treatment. The dose-responses analysis indicated that curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration in a non-linear model. Subgroup analysis according to duration and dose of treatment and target population revealed diverse outcomes. Curcumin could have a beneficial effect in reducing the proinflammatory cytokines IL-1 and TNF-α.

A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis
Studies on Biomarkers and New Targets in Aging Research | August 2021
There is growing evidence that curcumin has anti-inflammatory properties and could be a potential therapeutic option for chronic inflammatory diseases. Hence, curcumin could potentially have a positive impact on osteoarthritis symptoms. There was a significant improvement in VAS and overall WOMAC scores with oral administration of various types of curcumin formulations with no severe adverse effects. In conclusion, different types of curcumin compounds may be beneficial as an alternative or complementary agent for the management of osteoarthritis.

Neuroprotective Effects of Curcumin in Cerebral Ischemia
ACS Chemical Neuroscience | August 2021
Curcumin, a polyphenol that is abundantly present in the rhizome of the turmeric plant (Curcuma longa), has shown promising neuroprotective effects in animal models of neurodegenerative diseases, including cerebral ischemia postischemic brain including antioxidant, anti-inflammatory, antiapoptotic, vasculoprotective, and direct neuroprotective efficacies. Importantly, neuroprotective effects of curcumin has been reported in both ischemic and hemorrhagic stroke models. A broad-spectrum neuroprotective efficacy of curcumin suggested that curcumin can be an appealing therapeutic strategy to treat cerebral ischemia.

5 Science-Backed Health Benefits Of Curcumin
Forbes Health | July 2021
 

Effect of moderate exercises and curcumin on hepatic transcriptional factors associated with lipid metabolism and steatosis in elderly male rat
Integrative/Functional Medicine | July 2021
Moderate aerobic exercise and curcumin alone or in combination completely masked this effect. Conclusion and implications: The findings revealed dyslipidemia and liver steatosis related to aging might be partly associated with changes in hepatic transcriptional factors which can be mitigatedmoderate aerobic exercise and curcumin.

Promising role of curcumin against viral diseases emphasizing COVID-19 management
Journal of Functional Foods
| July 2021
Curcumin has already acknowledged immense interest from both medical and scientific research because of its multifaceted activity. To date, the promising  influenza and HIV. The popular use of curcumin in research is mainly due to its pleiotropic properties including anti-inflammatory, anti-oxidant and anti-carcinogenic activities (Ahmad et al., 2020). Curcumin can inhibit the inflammatory mediators, oxidation processes, and oxidative stress thereby acts as an anti-inflammatory agent against many diseases (Wal et al., 2019). Praditya et al. (2019b) have shown curcumin as an anti-bacterial agent against several strains of Staphylococcus, Streptococcus, Helicobacter and Pseudomonas mainly by growth inhibition. They also reported the anti-fungal property of curcumin. Different studies identified the efficacy of curcumin against Human immunodeficiency virus (HIV), Herpes simplex virus (HSV), Hepatitis viruses etc. (Praditya et al., 2019a, Prasad and Tyagi, 2015, Vitali et al., 2020). Although there are some controversies, the majority of the studies support the potential role of curcumin in inhibiting viral replication and growth inhibition (Mathew & Hsu, 2018). Apart from these, long-term intake of curcumin can improve systolic blood pressure (Hadi et al., 2019), control obesity (Jarząb & Kukula-Koch, 2019), Type 2 Diabetes Mellitus (Pivari et al., 2019). Also, curcumin often acts as a cardio-protective, nephroprotective, anti-neoplastic, hepato-protective and anti-rheumatic compound. While the entire world is putting efforts into the discovery of a vaccine against coronavirus infection, the antiviral potential of curcumin against SARS-CoV-2 shows a promising role in COVID-19 management. Since ancient time, curcumin possesses a multifaceted role in several disease management. As an antiviral agent, existing literature suggested that targeting viral lifecycle and cellular responses are important strategies to combat viral infection. The present review emphasized the molecular mechanism of host-pathogen interaction and subsequent immune response in the host. In this background, curcumin can potentially inhibit the SARS-CoV-2 entry within human mainly by blocking the ACE2 ced multi-organ failure by constraining the inflammatory response and other cellular immune response.

Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells
Experimental and Therapeutic Medicine | July 2021
Curcumin is a main phenolic active compound in C. Longa Linn, and it has numerous pharmacological activities such as anti-inflammatory, antibacterial and, especially, anticancer activities. The anticancer effects of curcumin are due to targeting a wide range of cellular and molecular pathways involved in cancer pathogenesis. For example, curcumin has been revealed to induce endoplasmic reticulum stress-associated apoptosis in human PTC cells via disruption of intracellular calcium homeostasis and to affect PTC cells by targeting the JAK/STAT3 signaling pathway. In summary, curcumin suppressed the cell viability, migration, invasion and EMT of TPC-1 cells. Moreover, curcumin treatment increased miR-301a-3p expression and inhibited STAT3 expression. Overexpression of miR-301a-3p inhibited cell viability, migration, invasion, and EMT and the JAK/STAT signaling pathway by targeting STAT3, and miR-301a-3p inhibitors and STAT3 overexpression reversed the curcumin-induced cell viability, migration, invasion and EMT of TPC-1 cells. Collectively, curcumin played an anticancer role in TPC-1 cells by regulating miR-301a-3p/STAT3, indicating that curcumin is a promising oncotherapeutic agent. These findings may provide a possible strategy for the clinical treatment of PTC.

Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy
Renal Failure | July 2021
Curcumin is a natural phenolic compound derived from the rhizome of the plant curcuma longa, and it is the main ingredient of turmeric. A large number of studies have confirmed that curcumin exerts a wide range of biological effects, including anti-tumor, anti-inflammatory, anti-oxidation, and anti-fibrosis. Based on the above pharmacological effects, there have been many animal experiments and cellular experiments using curcumin to prevent and treat various kidney diseases in recent years, and even a few preliminary reports on the clinical application of curcumin in the treatment of renal diseases. Moreover, curcumin has also been shown to have the effects of regulating intestinal flora and improving gut barrier function in multiple diseases, like diabetes, ulcerative colitis, and colorectal cancer. Curcumin treatment protected against the overgrowth of opportunistic pathogens in UAN, including Escherichia-Shigella and Bacteroides, and increased the  could modulate gut microbiota, fortify the intestinal barrier, attenuate metabolic endotoxemia, and consequently protect the renal function.

Anti-inflammatory effects of curcumin in acute lung injury
International Immunopharmacology | July 2021
Curcumin reduces pyroptosis by inhibiting the expression of NLRP3. In conclusion, curcumin has protective effect against acute lung injury. It may inhibit inflammatory process by inhibiting the activation of NLRP3 inflammasome-dependent pyroptosis through the up-regulation of SIRT1.

A Novel Potent Sleep-Promoting Effect of Turmeric
Molecular Nutrition & Food Research | June 2021
Turmeric extract has a sleep-promoting effect owing to reduction in sleep latency and enhancement of NREMS via H1R blockade; therefore, it could be useful in insomnia.

Curcumin inhibits classical swine fever virus replication
Microbiology | June 2021
Previous reports have shown that Curcumin inhibits many viruses, including some important members of different genera of Flaviviridae family (Japanese encephalitis virus, dengue virus and hepatitis C virus). Curcumin inhibited classical swine fever virus replication by interfere lipid metabolism. In addition, our subsequent studies found that curcumin played an antiviral role by promoting the innate immune independent of NF-κB signaling pathway. Taken together, our finding highlights that curcumin is a potential candidate drug against classical swine fever virus for controlling classical swine fever.

Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level
Journal of Pharmaceutical and Biomedical Analysis | June 2021
Natural product curcumin was demonstrated to have a variety of pharmacological effects, such as anti-tumor, anti-oxidation and anti-aging activities.  Curcumin increased the cytotoxicity of Dox in SW620/Ad300 cells. Curcumin reduced the biosynthesis of polyamine and D-glutamine metabolism to reverse MDR. Curcumin inhibited the ODC expression, thererby decreasing the biosynthesis of polyamine.  Curcumin could be a promising multidrug-resitance reversal agent for cancer treatment.

Curcumin suppresses the malignancy of non-small cell lung cancer
Biomedicine & Pharmacotherapy | June 2021
Curcumin exerts a suppressive effect in tumor growth by acting as a modulator of multiple molecular targets.  Curcumin, a traditional herbal medicine, is discovered in Curcuma longa. It is a polyphenol and has many activities, including controlling diabetes, improving brain function, oxidation, anti-inflammatory, anti-tumor, and so on. It has been reported that curcumin plays an important role in various cell signal transduction by acting as a modulator of multiple molecular targets. Also, curcumin plays a repressive role in the advancement of NSCLC. Zhang et al. manifested that curcumin synergistically constrained cell malignancy. Furthermore, curcumin played an anti-tumor activity in NSCLC cells. Curcumin has attracted the attention of scientific researchers all over the world because of its anti-cancer potential. Accumulated studies have revealed that curcumin can target cell signaling pathways related to cancer development. For example, curcumin elevated miR-99a expression in retinoblastoma cells, thereby blocking the JAK/STAT pathway and repressed cell malignancy. Moreover, curcumin inhibited the proliferation of glioblastoma cells via blocking the AKT/mTOR pathway. Recent research revealed that curcumin elevated nasopharyngeal cancer radio-sensitization through regulating the circRNA/miR/mRNA network. Herein, we discovered that curcumin curbed the malignancy of NSCLC cells through repressing the circ-PRKCA/miR-384/ITGB1 pathway.

Curcumin and rheumatoid arthritis: A systematic review of literature
International Journal of Clinical Practice | June 2021
Curcumin is a natural polyphenol and the main compound from the rhizome of Turmeric (Curcuma longa) and other Curcuma species. It has been widely used for different medical purposes, such as improvement of pain and inflammatory conditions in various diseases. Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family, extracellular signal-regulated protein kinase, activator protein-1 and nuclear factor kappa B are the main mechanisms associated with the anti-inflammatory function of curcumin in RA. The results of the only human study showed that curcumin significantly improved morning stiffness, walking time and joint swelling. In conclusion, curcumin seems to be useful, and it is recommended that more human studies be performed to approve the cellular and animal results and determine the effective and optimal doses of curcumin on RA patients.

The efficacy and safety of Curcuma longa Extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis
Bioscience Reports | June 2021
Curcuma longa Extract and curcumin may be a safer and effective supplement for osteoarthritis patients. It is recommended to use Curcuma longa Extract and curcumin supplement for osteoarthritis patients for more than 12 weeks. Curcumin is a natural active oxygen scavenger and active nitrogen provider, and has been proven to be effective in treating pain caused by arthritis and osteoarthritis. Compared with NSAIDs, Curcuma longa Extract and curcumin have similar effects on joint pain, function and stiffness. However, the incidence of adverse events in Curcuma longa Extract and curcumin was lower.  Compared with the NSAIDs group, Curcuma longa Extract and curcumin+NSAIDs can also relieve pain (decrease the VAS and WOMAC score-pain), improve the joint function (decrease the WOMAC score-function), and improve the joint stiffness (decrease the WOMAC score-stiffness); in terms of adverse events, the addition of Curcuma longa Extract and curcumin to NSAIDs did not increase adverse events. Our meta-analysis also showed that Curcuma longa Extract and curcumin can improve oxidative stress in patients with osteoarthritis. Our meta-analysis shows that the combination of Curcumin and NSAIDs does not increase the occurrence of adverse events and has better efficacy. This is a promising result, because adding Curcumin supplementation in the case of using NSAIDs may increase the efficacy and perhaps reduce the dosage of NSAIDs.

Study presents evidence supporting the use of curcumin as alternative treatment for kidney fibrosis
The Gary Null Show | June 2021
Curcumin is an effective alternative treatment for renal fibrosis According to several animal studies, curcumin can protect the kidneys by preventing the development of renal fibrosis. The researchers found that curcumin (3.125 and 25?micromol/L) effectively promoted HKC proliferation. After 72 hours of incubating HKCs with TGF-B1 and curcumin, curcumin caused the cells to maintain epithelial morphology in a dose-dependent manner. It also decreased the expression of EMT-related proteins, such as vimentin, a-SMA and FSP1, and increased the expression of E-cadherin and cytokeratin. In addition, the researchers noted that curcumin reduced Akt, mTOR and P70S6K phosphorylation, which effectively suppressed the activation of the Akt/mTOR pathway in HKCs. Based on these findings, the researchers concluded that curcumin is an effective alternative treatment for renal fibrosis because it can promote HKC proliferation and stop EMT by inhibiting the activation of the Akt/mTOR pathway activity.

The Role of Curcumin in Gastrointestinal Cancers
Advances in Experimental Medicine and Biology | June 2021
Curcumin has been used in combinations with many anti-tumor drugs to increase their anticarcinogenic properties. Taken together, curcumin falls within the category of plant-derived substances capable of preventing or treating gastrointestinal cancers. Curcumin is a natural compound derived from turmeric with a wide range of biological activities. Several in vitro and in vivo studies have investigated the effects of curcumin on gastrointestinal cancers. In the current review, we aimed to provide an updated summary on the recent findings regarding the beneficial effects of curcumin on different gastrointestinal cancers in the recent curcumin can inhibit cell growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis and autophagy by interacting with multiple molecular targets. In vivo studies performed in various animal models have confirmed mainly the chemopreventive effects of curcumin.

Effect of eight-week curcumin supplementation with endurance training on glycemic indexes in middle age women with type 2 diabetes
Diabetes & Metabolic Syndrome: Clinical Research & Reviews | June 2021
Eight weeks of curcumin supplementation and endurance training, whether done separately or simultaneously, significantly reduced fasting blood glucose, glycosylated hemoglobin and serum insulin levels (P < 0.05). The combination of curcumin supplementation and endurance training compared to the other two interventions caused a significant further decrease in these glycemic indexes (P < 0.05). The findings of this study showed that eight weeks of curcumin supplementation and endurance training helped each other in improving the glycemic indexes of women with type 2 diabetes.

The protective effect of curcumin on rats with DSS-induced ulcerative colitis and its mechanisms
Research Square | May 2021
Curcumin is a traditional Chinese herbal medicine that is used for anti-inflammation in China and Southeast Asia. Curcumin has antioxidant, anti-inflammatory, anticancer and antiapoptotic properties. The advantages of curcumin, such as few adverse reactions, high levels of safety, and good compliance, have attracted the attention of many researchers. Studies have shown that curcumin can reduce airway inflammation by regulating the balance of Treg/Th17 cells in asthma models. In IBD model mice with genetic deletion of IL-10, an emulsion of curcumin in sodium carboxymethyl cellulose induced anti-inflammatory effects. The curcumin group exhibited significantly reduced DAI scores and improvements in histopathological damage. The expression of CD4+IL-17+ Th17 cells was significantly lower and the expression of CD4+CD25+Foxp3+ Treg cells was significantly higher in the curcumin group than in the DSS group.  Curcumin may be a new and effective treatment for IBD by regulating the balance of Treg/Th17 cells and the expression of IL-10 and IL-17A. The present study showed that compared with those of IBD rats in the DSS group, IL-10 levels of IBD rats in the curcumin group were significantly higher. Therefore, the protective effect of curcumin was related to IL-10. In summary, curcumin attenuated colonic tissue damage in DSS-induced UC rats by improving the Treg/Th17 cell balance and influencing the expression of inflammatory cytokines.

Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells
Oncology Reports | May 2021
Curcumin, a phytochemical from rhizomes of the plant Curcuma longa, has been reported to exert potential anticancer properties in various cancer types, including acute myeloid leukemia (AML). Collectively, the present study demonstrated that curcumin exerted anti-AML roles by inactivating AKT and these findings may aid in the treatment of AML.

Effects of curcumin supplementation on sport and physical exercise
Critical Reviews in Food Science and Nutrition | May 2021
Curcumin supplementation displayed significant reductionof inflammation derived from the physical exercise. After curcumin supplementation there was a significantimprovement in some aspects of muscle recovery and performance in exercise. Curcumin has recently drawn worldwide attention ofresearchers (Salehi et al.2019), who conducted studies thatindicated that its medicinal properties are associated withthe reduction of pain (Karlapudi et al.2018; Sun et al.2018), anti-inflammatory effects (Ghandadi and Sahebkar2017; Mollazadeh et al.2019), besides prevention and treat-ment of cardiovascular (Li et al.2020; Momtazi-Borojeniet al.2019) and gastrointestinal (GI) diseases (Ghosh et al.2018; Mazieiro et al.2018), cancer (Kunnumakkara et al.2017; Mizumoto et al.2019; Talib et al.2018) and otherchronic diseases (Kunwar and Priyadarsini2016; Prasadet al.2014; Salehi et al.2019; Sharan Patel et al.2019).Also, studies that employed animal models reportedpositive results of curcumin supplementation for physicalactivity and sport performance (Huang et al.2015), thussupporting muscle recovery and reduction of inflammation(Davis et al.2007), improvement of mitochondrial biogen-esis (Ray Hamidie et al.2015), reduction of oxidative stress(Kawanishi et al.2013), prevention of fatigue and muscledamage (Huang et al.2015; Sahin et al.2016).  The evidences presented indicate that cur-cumin supplementation in human beings is likely safe andbeneficial for sport and physical activity, due to the reduction of inflammation and oxidative stress, reduction of painand muscle damage, improved muscle recovery, sport performance, psychological and physiological responses (thermal and cardiovascular) during training, as well as the GI function.

Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer
Advances in Experimental Medicine and Biology | May 2021
Phytochemicals are various compounds produced by plants. There is growing evidence on their potential health effects. Some of these compounds are considered as traditional medicines and used as painkillers, anti-inflammatory agents, and for other applications. One of these phytochemicals is curumin, a natural polyphenol derived from the turmeric plant (Curcuma longa L.). Curcumin is widely used as a food coloring, preservative and condiment. It has also been shown to have antioxidative and anti-inflammatory effects. Moreover, there is growing evidence that curcumin alters long noncoding RNAs (lncRNAs) in many kinds of cancer. These noncoding RNAs can cause epigenetic modulation in the expression of several genes. This study reviews reports of curcumin effects on lncRNAs in lung, prostate, colorectal, breast, pancreatic, renal, gastric, and ovarian cancers.

The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects
Phytotherapy Research | May 2021
Curcumin and zinc have been studied as an antioxidant, antiinflammatory, and antidiabetic agents. Based on these results, zinc and curcumin supplementation exerted a beneficial effect on several key glycemic parameters.

Curcumin Reduces Neuroinflammation and Improves the Impairments of Anesthetics on Learning and Memory
Neuroimmunomodulation | May 2021
Curcumin has a protective effect on ISO-induced cognitive dysfunction, which may be achieved by regulating the expression of miR-181a-5p.

Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes
BioFactors | May 2021 we discuss clinical trials in which curcumin is used as a therapeutic agent for the treatment of diseases linking to protein aggregates.

Anti-Inflammatory Effect of Curcumin on Rheumatoid Arthritis
Pharmaceuticals | May 2021
Recent studies reveal that curcumin, a natural dietary anti-inflammatory compound, can modulate the response of the cells engaging in RA course. Interestingly, many studies have described the potential role of curcumin as an epigenetic modifier. This potent herbal drug has been identified as an inhibitor of DNA methyltransferases (DNMTs), regulator of histone acetyltransferases (HATs), deacetylases (HDACs), and microRNAs, as well as a DNA binding agent. Curcumin has been found to significantly reduce H3ac levels in the IL-6 promoter as well as IL-6 mRNA expression in rheumatoid arthritis synovial fibroblasts (RASFs). The role of curcumin as an epigenetic modifier has been well documented in cancer, neurological disorders, and some inflammatory diseases. Curcumin is a polyphenolic substance naturally occurring in turmeric, especially in Curcuma Longa, with broad anti-inflammatory properties and proven positive effects in autoimmunological disease therapies, including Rheumatoid Arthritis. Curcumin is an antioxidant, which means it can efficiently reduce the level of reactive oxygen species (ROS), weaken redox signaling, and reduce inflammation [22]. In addition to having direct antioxidant properties, curcumin also blocks the activity of ROS-generating enzymes like lipoxygenase (LOX), cyclooxygenase (COX), xanthine dehydrogenase, and nitric oxide synthase (iNOS). Despite reducing ROS levels, curcumin also possesses numerous other properties that enable its usage as a potential therapeutic drug targeted against Rheumatoid Arthritis. Interesting insights into this matter are provided by recent studies, which found that this natural compound can suppress proinflammatory pathways related to the immune cells crucial in RA development. Therefore, curcumin’s daily consumption can decrease inflammation and oxidative stress, contributing to the immune system’s modulation and alleviating the rheumatoid arthritis course.

Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways
Phytotherapy Research | May 2021
Curcumin is a bright yellow substance isolated from the plant rhizomes of Curcuma longa L. To this molecule a high therapeutic benefit has been underlined, being able to alter the development of cancer by different mechanisms, such as regulating multiple microRNA expression, modifying a series of signalling pathways.

 

Curcumin alleviates high-fat diet-induced hepatic steatosis and obesity in association with modulation of gut microbiota in mice
Food Research International | May 2021
Curcumin alleviated hepatic steatosis and insulin resistance in obese mice. Curcumin increased abundance of Bacteroides, Parabacteroides, Alistipes and Alloprevotella. Curcumin increased the caecal and colonic short chain fatty acids (SCFA) contents. Curcumin reduced endotoxin-producing Desulfovibrio bacteria and circulating serum LPS. The dominant bacterial taxa altered by curcumin were related with improvement of obesity.

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review
Frontiers in Endocrinology | May 2021
The genus Curcuma (Zingiberaceae) includes perennial rhizomatous plants native to subtropical to tropical regions. The main part of the plant is the rhizomes, and the most prevalent active components are the curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin). Curcuminoids are nontoxic polyphenolic that exerts a wide range of biological activities, such as the production of significant immunosuppressants that inhibit the production of IL-2 and IL-12. This compound inhibits the expression of iNOS (inducible nitric oxide synthase), COX-2 (cyclooxygenase-2), lipoxygenase-5, and many other pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6, and IL-8. Curcuminoids can also regulate apoptosis and suppress neurotoxic factors in macrophages and alveolar monocytes stimulated by lipopolysaccharides. Besides, it inhibits phosphorylation and degradation of IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) and activates the γ receptor mechanism activated by peroxisome proliferator, reducing inflammation pattern induced by NF-κBe biological effects may include the inhibition of reactive oxygen species (ROS) production, playing a fundamental role, particularly for diseases related to oxidative stress and inflammation, such as DM. Figure 3 shows some systemic effects of curcumin. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE wereto its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. The singular characteristic of this plant is the presence of curcumin, which shows antioxidant and anti-inflammatory properties. Besides that, curcumin has a potential role in preventing and treating several diseases due to various actions such as anti-bacterial, anti-diabetic, anti-viral, and anticancer activities. Curcuminoids have been shown to improve insulin resistance, decrease glucose and insulin levels, increase adiponectin release, and reduce the levels of leptin, resistin, interleukin (IL)-6 IL-1β, and tumor necrosis factor-α in patients with T2DM. These findings suggest that these compounds can affect glucose homeostasis and diabetic complications, and the vascular risk of patients with T2DM. Some studies have shown that supplementation of curcuminoids improves the lipid profile and increases the total antioxidant capacity of patients with T2DM, thus supporting other available evidence on the role of curcuminoids in modifying cardiometabolic risks.

Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19
Advances in Experimental Medicine and Biology | May 2021
Mechanisms and special clinical considerations of supplementation with curcumin as an anti-inflammatory and antioxidant compound in the setting of COVID-19 clinical research.

Anticancer Mechanism of Curcumin on Human Glioblastoma
Nutrients | May 2021
Curcumin is the most studied compound described as a potential anticancer agent due to its multi-targeted signaling/molecular pathways properties. Curcumin possesses the ability to modulate the core pathways involved in GBM cell proliferation, apoptosis, cell cycle arrest, autophagy, paraptosis, oxidative stress, and tumor cell motility. This review discusses curcumin's anticancer mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-κB pathways, which are commonly involved and dysregulated in preclinical and clinical GBM models.

Micronutrients and bioactive substances: Their potential roles in combating COVID-19
Nutrition | April 2021
A study has shown that curcumin interfered with the binding of enveloped viruses to cell surface. Derivatives of curcumin exhibited antiviral activity against the vesicular stomatitis virus. Curcumin also exhibited antiviral properties against dengue virus and hepatitis C virus. Having immunomodulating, antiinflammatory, antioxidant, and antiviral properties, such micronutrients and bioactive substances are consequently promising alterative nutritional approaches to combat COVID-19 infection.

Curcumin suppresses colorectal cancer stem cells
Journal of Natural Medicines | April 2021
Curcumin is a polyphenol extracting from Curcuma longa. It has been demonstrated that curcumin possesses extensive therapeutic activities against multiple ailments, such as inflammation, metabolic syndrome, liver disease, arthritis, and neurodegenerative disease. In the recent years, researchers found that curcumin has played an important role in cancer prevention and treatment. For instance, curcumin induced apoptosis of castration-resistant prostate cancer cells, partially dependent on its iron-chelating properties; curcumin could overcome gefitinib-resistance in nonsmall-cell lung cancer cells via inducing autophagy-related cell death. Other studies indicated curcumin suppressed oncogenicity of human colon cancer cells, through covalent modification of SIRT1 at the cysteine 67 residue and the proteasomal degradation of oncogenic SIRT1. In this study, we observed that curcumin inhibited tumorsphere formation, decreased cell viability in a dose-dependent manner. Curcumin also promoted apoptosis of LGR5(+) colorectal CSCs. In addition, curcumin can induce autophagy in many tumor cells. For example, curcumin inhibited proliferation, induced the autophagy and apoptosis in gastric cancer cells. Similarly, our data suggest that curcumin increased tumor cell death partly by inducing autophagy, because the effect of curcumin-induced cell proliferation inhibition was decreased by co-treatment with the autophagy inhibitor, HCQ. Therefore, these results reveal that curcumin-induced autophagy may contribute to the antitumor effects of curcumin on LGR5(+) colorectal CSCs.  In summary, we found that curcumin suppresses the proliferation of LGR5(+) colorectal CSCs by inducing autophagy and transcriptionally repressing the oncogenic TFAP2A-mediated ECM pathway. Lastly, while our study entailed mostly in vitro experiments, further studies, especially in vivo, are needed to understand the mechanism of effect of curcumin in LGR5(+) colorectal CSCs and to evaluate this potential therapeutic approach to CRC. In addition, the correlation between TFAP2A-mediated ECM pathway and autophagy also deserves further study.

Beneficial Effects of Curcumin Supplementation on Sports Performance and Physical Exercise
Designs For Health | April 2021
Turmeric has three main bioactive components: curcumin, desmethoxycurcumin, and bisdemethoxycurcumin. These curcuminoids have many biological effects, including properties that are anti-inflammatory, antioxidant, anti-tumor, antimicrobial, and antiviral. This review investigated the evidence for the effects of curcumin supplementation for humans on sports performance and physical exercise. Curcumin possesses the ability to inhibit transcription factors (e.g., nuclear factor [NF]-κβ) that are responsible for activating pro-inflammatory enzyme and cytokine expression, such as cyclooxygenase (COX)-2, 5-lipoxygenase (LOX-5), tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, and IL-8, suggesting their importance in helping to reduce post-exercise inflammation. The treatment groups with doses ranging from 180 mg to 5 g of curcumin per day showed significant reductions in inflammation caused by physical exercise compared to the placebo group, whose participants displayed elevated IL receptor agonist activity of IL-6, IL-8, and IL-10, and TNF-α concentrations. Compared to the treatment group, a gastrointestinal (GI) barrier damage marker (fatty acid−binding protein) was elevated after aerobic exercise in the placebo group, suggesting curcumin may improve GI function during exercise-induced exertional heat stress. Overall, the results of this systematic review showed positive effects with no adverse symptoms or injuries reported. Curcumin supplementation improved exercise-induced muscle recovery, muscle performance, psychological and physiological parameters, function, and reduced inflammation, oxidative stress, pain, and muscle damage caused by aerobic and resistance training. Although larger clinical trials are needed, the evidence suggests that curcumin supplementation may be a safe and effective option for supporting sports and exercise performance in humans.

Curcumin suppresses colorectal tumorigenesis
Oncology Letters | April 2021
Curcumin, a natural product extracted from the rhizome of Curcuma longa, is a drug with strong pharmacological effects and limited side effects. Increasing evidence have confirmed that curcumin exerts antioxidant, antibacterial, anti-inflammatory, antiproliferation and anticancer effects. Furthermore, curcuminoids have advanced CRC who were resistant to chemotherapy for 4 months. The results demonstrated that treatment with curcumin was well tolerated and there was no toxicity at any doses. Previous studies have reported several molecular mechanisms for the anticancer effects of curcumin . For example, curcumin inhibits Axin2 expression in the colorectal cancer line, HCT116, and modulates the Wnt/β-catenin signaling pathway. Yan et al demonstrated that Axin2 is upregulated and the Wnt/β-catenin signaling pathway is activated in human colon tumor samples. It has also been reported that curcumin can target colorectal stem cells via the Wnt pathway to inhibit their proliferation and drug resistance to chemotherapy, indicating the important role of the Wnt/β-catenin signaling pathway in the tumorigenesis of CRC. Another study demonstrated that curcumin inhibits the proliferation and induces apoptosis of human non-small cell lung cancer cells via the PI3K/Akt signaling pathway. Furthermore, the results of a squamous cell carcinoma study reported that curcumin inhibits cancer cell proliferation via the epidermal growth factor receptor signaling pathway. In addition to the effects of curcumin on CRC progression through the NBR2/AMPK/mTOR pathway, curcumin regulates the NF-κB and Src protein kinase signaling pathways by inhibiting IκBα kinase activation and IκBα phosphorylation. Collectively, these results indicate several molecular mechanisms of the anticancer effects of curcumin in vitro. However, the in vivo mechanism remains to be elucidated. Thus, the present study aimed to investigate the anticancer effects of curcumin and determine its underlying mechanisms in CRC, in vivo.

Protective Effects of Curcumin on Sperm and Stereological Parameters in Testes of Formaldehyde-Exposed NMRI Mice: An Experimental Study
International Journal of Medical Laboratory | April 2021
Curcumin (diferuloylmethane) is the main curcuminoid of turmeric, which is a known spice. It has been shown that curcuminoids are polyphenols and are responsible for the yellow-orange color of turmeric. Noorafshan and colleagues previously showed that curcumin protects the Leydig cells against metronidazole treatments. In another study, curcumin reduced testicular damage in diabetic rats by reducing oxidative stress.Moreover, Farombi et al. used curcumin to prevent oxidative changes and enhance sperm motility and reduce sperm abnormalities. This study showed that curcumin could reduce formaldehyde-induced damage to 

Telomerase: A Target for Therapeutic Effects of Curcumin in Cancer
Advances in Experimental Medicine and Biology | April 2021
Curcumin has been shown to be effective against several types of malignancies and has also been shown to have inhibitory effects on telomerase activity. Based on the findings obtained from the different studies here, we conclude that the telomerase inhibitory effects of curcumin are integral to its anticancer activity, and thus curcumin may be useful therapeutically in the cancer field.

Curcumin as Anti-infective Agents
Current Medicinal Chemistry | April 2021
Curcumin, a redox-active natural product, has for centuries been used in Asian traditional medicine for the treatment of various diseases. It is known for possessing multiple biological and pharmacological activities. Curcumin has been investigated extensively over the years for its anti-inflammatory, anticancer, antiparasitic, antiviral and antibacterial activities, and no toxicity is associated with the compound. Curcumin is still in clinical trials for the treatment of diseases

The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers
Molecules | April 2021
Curcumin, from the root of the turmeric plant Curcuma longa, is an extended pseudosymmetric polyphenol (diferuloylmethane). Zhou et al. showed that curcumin prevents bone loss in an experimental periodontitis model. In association with studies that do demonstrate an effect on the prevention of bone loss, these investigations have shown that curcumin has a profound effect on inflammation by significantly reducing the development of an inflammatory infiltrates within the periodontal lesion while simultaneously stimulating an increase in the collagen content, as well as an increase in the number of fibroblastic cells within the periodontium and associated lesions when curcumin was administered daily to rats with experimentally induced periodontitis. Curcumin, the major component of turmeric, has been shown to have anti-inflammatory, antimicrobial and antioxidant action. In vitro studies, animal studies and clinical studies have demonstrated that there is a positive association between curcumin and the evolution of periodontitis. It can be concluded that the oral administration of curcumin and rutin, single or combined, could reduce oxidative stress both in gingival tissue and blood and enhance the antioxidant status in hyperglycemic periodontitis rats. Modeling oxidative stress, these two antioxidants may have an inhibitory effect on inflammation.

Curcumin induces ferroptosis in non‐small‐cell lung cancer
Thoracic Cancer | April 2021
Emerging studies showed curcumin can inhibit glioblastoma and breast cancer cells via regulating ferroptosis. Curcumin is a yellow polyphenol compound derived from the turmeric plant, which shows anticancer properties through a variety of mechanisms, including inhibition of tumor proliferation, invasion and metastases, regulation of apoptosis, and autophagy. Recent studies showed that curcumin can treat glioblastoma and breast cancer via regulating ferroptosis. In conclusion, our results provide evidence that curcumin could induce ferroptotic cell death of NSCLC cells via activating autophagy.

Curcumin Ameliorated Oxidative Stress and Inflammation-Related Muscle Disorders
Antioxidants | April 2021
Curcumin has also been reported to possess diverse pharmacological effects including antioxidant and anti-inflammatory activities. Recently, it has been suggested that curcumin alleviated chronic kidney disease-induced muscle atrophy by inhibiting glycogen synthase kinase (GSK)-3β.  The present study demonstrated that curcumin  in C2C12 myoblast cells showed in vitro antioxidant and anti-inflammatory activities. Specifically, curcumin enhanced DPPH radical scavenging activity in a dose-dependent manner, and it did not affect the cell viability of C2C12 cells with concentrations up to 30 μg/mL. Furthermore, curcumin significantly suppressed H2O2-induced cell toxicity, ROS generation, and lipid peroxidation and restored GSH depletion, which involved an increase of antioxidant genes through Nrf2 activation, providing evidence that curcumin can protect cells by reducing oxidative stress. Besides, curcumin significantly inhibited LPS-mediated IL-6 productions. Therefore, curcumin could be a useful candidate against oxidative stress and inflammation-related muscle disorders.

Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation
ACS Omega | April 2021
Curcumin is a polyphenolic substance extracted from turmeric, a plant of the curcuma family. Toxicity studies have shown that it is quite safe even at high doses  the United States. Curcumin, as an effective anti-inflammatory small molecule, was shown to inhibit the COX-2 expression in human colon cancer cells. Recently, Wang et al. have proven that curcumin can inhibit ApoE4-induced injury by upregulating the expression of peroxisome proliferator-activated receptor-γ to inhibit the activation of NF-κB signaling in SH-SY5Y cells. Apart from the anti-inflammatory role, curcumin also acts as a known antioxidant that scavenges reactive oxygen species. Zheng et al. found that curcumin can protect SH-SY5Y cells against appoptosin-induced intrinsic caspase-dependent apoptosis by increasing heme oxygenase-1 expression and reducing ROS production.  Chhunchha et al. also proposed that curcumin could reinforce the naturally occurring Prdx6 expression, attenuate ROS-based ER stress and NF-κB-mediated aberrant signaling, then improve the survival of mouse hippocampal cells (HT22), and may provide an osteoarthritis development in vivo. Together, the previous studies focused either on the anti-inflammatory effect of curcumin in vitro under various stimuli or on its protection against ER stress in other inflammatory diseases.

Curcumin protects against inflammation and lung injury in rats with acute pulmonary embolism
Molecular and Cellular Biochemistry | April 2021
Curcumin decreased miR-21 expression by downregulating Sp1 to upregulate PTEN and to impair the NF-κB signaling pathway, thus suppressing lung injury and inflammation in APE rats.

Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
Heliyon Cell Press | March 2021
Curcumin, a bioactive compound in turmeric, exerts diverse pharmacological activities and is widely used in foods and traditional medicines. This review presents several lines of evidence, which suggest curcumin as a promising prophylactic, therapeutic candidate for COVID-19. First, curcumin exerts antiviral activity against many types of enveloped viruses, including SARS-CoV-2, by multiple mechanisms: direct interaction with viral membrane proteins; disruption of the viral envelope; inhibition of viral proteases; induce host antiviral responses. Second, curcumin protects from lethal pneumonia and ARDS via targeting NF-κB, inflammasome, IL-6 trans signal, and HMGB1 pathways. Third, curcumin is safe and well-tolerated in both healthy and diseased human subjects. In conclusion, accumulated evidence indicates that curcumin may be a potential prophylactic therapeutic for COVID-19 in the clinic and public health settings.

Curcumin suppresses the stemness of non‐small cell lung cancer cells
Environmental Toxicology | March 2021
Curcumin has been shown to suppress the progression of lung cancer, however, the underlying mechanisms are largely unknown. Our results suggest that curcumin can attenuate the stemness of lung cancer cells through promoting TAZ protein degradation and thus activating Hippo pathway.

The Effect of Curcumin Supplementation on Overweight or Obese Adults
Nutrients | 2021
Curcumin has been shown to play a beneficial role in obesity management. Therefore, exploring the effects of certain herbs or dietary spices on obesity may be promising. Among these spices, curcumin, which is the primary component of the spice turmeric, has gained great interest for its multiple health benefits. Several randomized controlled trials have investigated the potential favorable effects of curcumin supplementation on anthropometric measures. The aim of this review is to evaluate the effect of curcumin supplementation on the anthropometric indices among overweight or obese adults. Curcumin supplementation may exert beneficial effects against obesity among overweight or obese adults.

Anticancer Mechanism of Curcumin on Human Glioblastoma
Nutrients | 2021
Curcumin is the most studied compound described as a potential anticancer agent due to its multi-targeted signaling/molecular pathways properties. Curcumin possesses the ability to modulate the core pathways involved in GBM cell proliferation, apoptosis, cell cycle arrest, autophagy, paraptosis, oxidative stress, and  its anticarcinogenic, antitumor, antioxidant, and anti-inflammatory actions. Curcumin is the most abundant compound and has been widely studied as a potential therapeutic agent in chronic diseases, such as neurodegenerative, cardiovascular, pulmonary, metabolic, and autoimmune diseases. For instance, curcumin was able to restore oxidative stress and DNA methyltransferase (DNMT) functions against diabetic retinopathy. Curcumin also acts as a wound healing promoting agent by facilitating collagen synthesis and fibroblast migration. Several pre-clinical and clinical studies also reported its anticancer effects in colorectal cancer, pancreatic cancer, lung cancer, and GBM. Curcumin can modulate multiple cellular signaling pathways and molecular targets involved in GBM tumor growth, migration, invasion, cell death, and proliferatio. Retinoblastoma (Rb), p53, MAP kinase (MAPK), P13K/Akt, JAK/STAT, sonic hedgehog (Shh), and NF-κB pathways are the most common targeted dysregulated pathways found in GBM and modulated by curcumin. Moreover, curcumin is highly lipophilic and able to

Curcumin + Celecoxib: a synergistic and rationale combination chemotherapy for breast cancer
European Review for Medical and Pharmacological Sciences | March 2021
This study is designed to explore the synergistic inhibitory effect of the combination of curcumin and celecoxib on the growth of human breast cancer cells. Our findings show the prominent anti-proliferative effects of celecoxib and/or curcumin on MDA-MB-231 cells, providing a rationale for further detailed preclinical and potential clinical studies of this combination for breast cancer therapy. Further, these computed parameters suggested that curcumin possesses a high tendency to act as an adjuvant drug with celecoxib in the treatment of breast cancer.

Immune-Stimulatory Effects of Curcumin on the Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma
Cancers | March 2021
Curcumin is known to have immune-modulatory and antitumor effects by interacting with more than 30 different proteins. An important feature of curcumin is the inhibition of nuclear factor kappa of activated B-cells (NF-κB).  Curcumin was more effective in inhibiting PIC-dependent NF-κB activation and Treg attraction compared to known NF-κB inhibitors BAY 11-7082 or caffeic acid phenethyl ester. The presented results show, for the first time, the immune-modulating effects of curcumin in HNSCC, with potent inhibition of the Treg-attracting effects of PIC. Hence, curcumin presents a promising drug in cancer therapy as a supplement to already established treatments.

Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation
Microorganisms | March 2021
Curcumin is the key component of the yellow pigment and the main bioactive molecule of turmeric. Chemically, this compound belongs to the class of natural phenolic compounds and has been broadly identified in diverse Curcuma spp. In 1910, curcumin was characterized as a symmetrical molecule of two 4-hydroxy-3-methoxyphenyl rings fastened by α,β-unsaturated carbonyl groups, while its synthesis was defined in 1913. Curcumin has been employed widely in the traditional medicine systems of various countries and regions in the world. Since the complete information about chemical structure and synthesis is acquired, curcumin has been extensively studied in various biological assays and has proven to induce numerous pharmacological and beneficial impacts on human health, including but not limited to the potential treatment of various viral infections such as human immunodeficiency virus, hepatitis B virus, hepatitis C virus, influenza A virus, human papillomavirus, respiratory syncytial virus, arboviruses, and noroviruses. Unlike the notable antimicrobial actions, this biomolecule induces several biological effects including but not limited to antioxidant, anti-inflammatory, and anticancer properties. We reviewed the curative properties of curcumin, a principal bioactive phenolic compound of the spice turmeric, in regard to various human and animal herpesvirus infections and inflammation connected with these diseases. According to the reviewed studies, this paper presents curcumin as a promising natural drug for the prevention and treatment of herpesvirus infections and their associated inflammatory diseases. In recent years, curcumin as a nutraceutical agent has attracted major attention in many research fields due to its great therapeutic potential against various biological targets. We have comprehensively reviewed the curative values of curcumin against numerous animal and human herpesviruses along with the mechanisms by which this compound induces antiherpetic properties, which were examined in vitro and in vivo investigations. Based on several structure-activity relationship studies, hydroxyl groups, carbonyl groups, and phenyl rings of curcumin were observed to be accountable for the induced anti-herpesvirus properties. In conclusion, this review proposes curcumin as a potent and safe drug for the therapy of herpesvirus infections as well as inflammation associated with these infections.

Roles of Curcumin in Sensitising the Cisplatin Effect on a Cancer Stem Cell-Like Population Derived from Non-Small Cell Lung Cancer Cell Lines
Molecules | March 2021
Natural compounds such as curcumin that contain high amounts of polyphenols can have a chemosensitivity effect that sensitises CSCs to cytotoxic agents such as cisplatin.  Curcumin significantly suppressed colonies formation by 50% and shrank the spheroids in cancer stem ce subpopulations, indicating inhibition of their self-renewal capability. This effect also was manifested by the down-regulation of SOX2, NANOG, and KLF4. Curcumin also regulated the niche of cancer stem cells  by inhibiting chemoresistance proteins, aldehyde dehydrogenase, metastasis, angiogenesis, and proliferation of cancer-related proteins. These results show the potential of using curcumin as a therapeutic approach for targeting cancer stem cells  subpopulations in non-small cell lung cancer. Curcumin (diferuloylmethane) is a naturally occurring polyphenol extract that is found in turmeric. Curcumin has long been used as a food, cosmetic, and traditional herbal molecules and pathways without any associated toxicity or resistance. One of the most compelling reasons for exploring curcumin is its sensitiser properties, which influence a diverse range of molecular targets within cells.

Focus on Multi-targeted Role of Curcumin: a Boon in Therapeutic Paradigm
Environmental Science and Pollution Research | March 2021
After thoroughly studying several articles on combination therapy of curcumin through authenticated book chapters, websites, research, and review articles available at PubMed, ScienceDirect, etc., it has been observed that multi-targeted curcumin possess enormous anticancer potential and, with whatever drug it is given in combination, has always resulted in enhanced effect with reduced dose as well as side effects. It is also capable enough in overcoming the problem of chemoresistance. Combining all the factors together, we can conclude that combination therapy of drugs with curcumin should be explored extensively

Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease
Integrative Medicine Research | March 2021
Meta-analysis of 4 randomized controlled trials including 228 subjects showed a trend toward significant reduction of ALT blood concentrations  suggests that curcumin/turmeric might have a favorable effect on NAFLD in higher dosage.

Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer
Clinical and Translational Oncology | March 2021
Curcumin has been reported to block cancer development by modulating multiple signaling pathways. The results showed that curcumin suppressed gemcitabine-resistant non-small cell lung cancer cell proliferation and induced apoptosis. Curcumin upregulated the expression of lncRNA-MEG3 and PTEN, and MEG3 overexpression could increase the level of PTEN expression, while MEG3 knockdown decreased the level of PTEN expression in gemcitabine-resistant non-small cell lung cancer cells. These findings show the antitumor activity of curcumin for potential clinical application in gemcitabine-resistant non-small cell lung cancer treatment.

Curcumin anti‐tumor effects on endometrial cancer with focus on its molecular targets
Cancer Cell International | March 2021
Curcumin is a phenolic antioxidant extracted from turmeric, which is frequently used as a spice and has a yellow color. The rhizome of the herb Curcuma longa is the origin of turmeric that contains turmerin protein as well as analogs of curcumin, demethoxycucumin, and bisdemethoxycurcumin. 1,7-bis(4-hydroxy-3- methoxyphenyl)-1,6-heptadiene-3,5-dione is the chemical name of curcumin and C21H20O6 is its empirical formula. Since curcumin and its two analogs have the same molecular and biological characteristics, it is suggested that bisdemethoxycurcumin converts to demethoxycucumin, which in turn, transforms into curcumin. While curcumin plays a variety of beneficial roles, studies on animals and humans have concluded that it is a safe agent even at high doses. Curcumin acts as an anti-oxidative, anti-microbial, anti-malarial, anti-HIV, and anti-angiogenic agent. Furthermore, it can be used in the treatment of inflammation, skin wounds, and neurodegenerative diseases.  Curcumin has complex chemistry and it is capable of targeting some signaling pathways. Moreover, it can interact with several intracellular and extracellular molecules. These features lead to anti-tumor effects of curcumin on various cancer cells and is useful at different stages, including prevention, treatment, and controlling the symptoms of cancers. There are studies concerned with the anti-tumor effects of curcumin in the treatment of EC. Curcumin plays these roles by involving various targets, such as signaling pathways, proteins, genes, and RNAs. Induction of apoptosis, reducing inflammation, and inhibiting cell migration are the results of curcumin treatment. Furthermore, there are some miRNAs whose effects on EC have been identified and curcumin has been observed to impact on these miRNAs but in other cancers. Altogether, curcumin should be considered as a therapeutic target in EC and its anti-tumor effects on this cancer deserve further exploration.

The protective effects of curcumin in cerebral ischemia and reperfusion injury through PKC-θ signaling
Cell Cycle | March 2021
Curcumin, a known antioxidant, has been found to have neuroprotective effects. To determine the protective mechanism of curcumin in ischemic stroke, oxygen and glucose deprivation/reoxygenation (OGD/R) was used to treat PC12 cells to mimic the cerebral I/R cell model. Our results demonstrated that curcumin could reverse the MCAO/R-induced increase in Ca2+ concentration and blood–brain barrier (BBB) disruption. Our study demonstrates the mechanisms by which curcumin exhibited a protective function against cerebral I/R through PKC-θ signaling by reducing BBB dysfunction.

Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT
Oncology Reports | March 2021
Curcumin, a phytochemical from rhizomes of the plant Curcuma longa, has been reported to exert potential anticancer properties in various cancer types, including acute myeloid leukemia (AML).  The present study demonstrated the anti-AML effect of curcumin both in vitro and in vivo.

Curcumin repairs intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer
National Library of Medicine | March 2021
Curcumin maintained the integrity of mucosal surface and villi structure of jejunum to a large extent, and reduced pathological changes in a dose-dependent manner. Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P&lt;0.05 or P&lt;0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P&lt;0.05 or P&lt;0.01), and upregulate the protein expression of E-cadherin(P&lt;0.05). Therefore, curcumin could repair the intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer, and the mechanism may be related to the inhibition of IL-6/STAT3 signal and the inhibition of epithelial-mesenchymal transition(EMT) process.

Effect of Curcumin, Exelon and their Combination on Brain in Alzheimer’s Disease-Induced Rats
 Journal of Advances in Medicine and Medical Research | March 2021
Curcumin is a natural product derived from Curcuma longa (more commonly known as turmeric). Curcumin has anti-inflammation and antioxidant activities, so it can decrease inflammation, amyloid accumulation and oxidative stress which has ability to scavenge free radicals. Also, it has protective potent from lipid peroxidation, and scavenges nitric oxide (NO)-based radicals. Curcumin has ability to inhibit formation of Aβ plaques and lower soluble Aβ levels due to its metal chelation properties as it binds to redox-active metal ions such as iron and copper. These complexes may cause a net protective effect through decreased Aβ aggregation. Curcumin is safe product which large quantities can consumed without toxicity. 

How curcumin affects hyperglycemia-induced optic nerve damage: A short review
Journal of Chemical Neuroanatomy | March 2021
Curcumin is effective in preventing the progression of diabetic complications and improving complications. Curcumin has healing effects in optic nerve damage with its anti-oxidant properties.

Effects of curcumin administration on Nesfatin-1 levels in blood, brain and fat tissues of diabetic rats
European Review for Medical and Pharmacological Sciences | March 2021
Curcumin administration caused significant improvement in fasting blood glucose levels.  For the first time, we found marked improvements in nesfatin-1 levels in blood, brain, and fat tissues of type 2 DM rats. Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1.

Curcumin Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote the Anabolism of Articular Chondrocytes and Cartilage Repair
Cell Transplantation | March 2021
Curcumin displayed multiple pharmacological activities including anti-inflammatory, antioxidant, and anticancer, and has been employed in different studies involving several pathologies such as cardiovascular disease, depression, Alzheimer’s disease, epilepsy, Parkinson’s disease, cancer, osteoporosis, rheumatic arthritis, and osteoarthritis. It could inhibit the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κβ) and synthesis of reactive oxygen species by reducing the production of IL-1, IL-6, IL-8, and tumor necrosis factor α via various pathways, and is emerged as an effective therapeutic agent. For osteoarthritis treatment, curcumin supplementation exhibited effects mainly based on its anti-inflammation, antioxidant, and antiapoptosis potentials15. In clinical trials, curcumin served as a natural product medicine displayed nearly no side effects, thus making it a potential alternative to NSAIDs and some other medications with known severe adverse effects. In the current study, curcumin enhanced the BMSC function for the proliferation and migration of articular chondrocytes, and anabolic gene expression of ECM in articular chondrocytes in vitro, and the regeneration of articular cartilage in vivo. These results indicated potential clinical application of curcumin cooperation with BMSCs in cartilage repair for osteoarthritis treatment.

Curcumin for amyloidosis and lipid metabolism - a novel insight
eLife Shinshu University | March 2021
Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties. In previous studies, curcumin has been shown to suppress the aggregation and cytotoxicity of many amyloid proteins in vitro, such as amyloid ß (Aß), α-synuclein, transthyretin, and prion protein, and has also been reported to inhibit the deposition of Aß fibrils in a mouse model of Alzheimer's disease.  These findings demonstrate the novel agonistic effect of curcumin on PPARα, which is an important transcription factor for lipid metabolism, and may have far-reaching significance for the treatment of amyloidosis and other metabolic disorders. In addition, it has been regarded that curcumin, as an agonist of PPARγ, exerts anti-inflammatory, anti-cancer and antioxidant activities in the past. However, this study demonstrates that curcumin is a PPARα/γ dual activator and may affect expression levels of proteins involved in amyloid deposition and other metabolism functions in a complex manner. By focusing on the PPARα pathway, the group hope to provide an opportunity to reconsider the mechanism of the physiological effects of curcumin.

A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats
Biochemistry and Biophysics Reports | March 2021
Administration of curcumin attenuated oxidative stress and inflammation in the serum, aorta and heart tissues induced by lipopolysaccharide LPS.

Anti-inflammatory Effect of Curcumin on Human Vitreous in Patients With Diabetic Retinopathy
Frontiers in Neurology | March 2021
Curcumin, a yellowish non-flavonoid polyphenol that constitutes the main active compound of Curcuma longa, is widely known for its antioxidant and anti-inflammatory properties. Many studies have also described its marked protective effect on retinal cells against oxidative stress and inflammation. Curcumin is a well-known bioactive molecule, largely employed in supplement formulation due to its anti-inflammatory properties. Our study highlighted the ability of curcumin to reduce cytokine levels in the vitreous of diabetic patients. We also observed an additional anti-inflammatory effect when curcumin was combined with homotaurine and vitamin D3, suggesting that these molecules can regulate the inflammatory network between the vitreous and retina at different levels. This effect is confirmed by the gene expression experiment which demonstrated that the combination of curcumin, vitamin D3, and homotaurine down-regulate the cyclinD1 gene and the pro-inflammatory cytokine genes TNFα and IL6 expression. 

Curcumin induces mitochondrial biogenesis by increasing cAMP levels via PDE4A inhibition in skeletal muscle
British Journal of Nutrition | March 2021
Previous research has suggested that curcumin potentially induces mitochondrial biogenesis in skeletal muscle via increasing cAMP levels. The present results suggest that curcumin increases cAMP levels via inhibition of PDE4A phosphorylation, which induces mitochondrial biogenesis through a cAMP/PKA/AMPK signalling pathway. Our data also suggest the possibility that curcumin utilizes a regulatory mechanism for mitochondrial biogenesis that is distinct from the exercise-induced mechanism in skeletal muscle.

Catechin and curcumin interact with S protein of coronavirus SARS-CoV2 and ACE2 of human cell membrane
Scientific Reports | February 2021
Several recent studies have suggested that natural polyphenolic compounds like catechins (GTCs; Green Tea Catechins) and curcumin (diferuloylmethane; from turmeric) have antiviral activities against a broad spectrum of viruses such as Human Immunodeficiency Virus (HIV), Herpes Simplex Virus, Influenza Virus, Hepatitis B and C Viruses (HBV and HCV respectively)14, Adenovirus15 and Chikungunya virus (CHIKV). Diverse mechanisms have been suggested to explain the antiviral activities of both the polyphenolic compounds. Curcumin has been demonstrated as a potent inhibitor of monophosphate dehydrogenase, a rate limiting enzyme in the de novo synthesis of guanine nucleotide22. Further, it has also been observed that GTCs and curcumin inhibit the expression of ACE2

ASU study looks at how Curcumin supplements might help post-COVID
AZFamily.com | February 2021
Researchers at Arizona State University are conducting a study into if whether or not two supplements can help reduce inflammation after having COVID-19. An ASU grad student is part of a research team, hoping to learn whether or not two supplements reduce inflammation after COVID-19. "It can either be Curcumin, which comes from the spice turmeric," said ASU Grad Student Samantha Fessler. "...the other one is Palmitoylethanolamide, and that comes from things like eggs and peanut oil...using these supplements with the flu, they've been proven to improve inflammation associated with the flu viral infection and also post-recovery from other types of chronic issues."

The potential role of curcumin in the prevention of COVID-19
Archives of Microbiology | February 2021
Due to the new coronavirus’ unexplored nature, we shed light on curcumin for its potential role against the disease. The current study showed the use of curcumin against the coronavirus and its possible role in developing medicine against it. Curcuma longa produces turmeric (diferuloylmethane), named Indian saffron in Europe, with its medicinal uses, including antiviral and anti-inflammatory actions. It has shown that curcumin has its inhibitory effects on the virus, including HIV, smallpox, measles, and chickenpox are being among its target. In the current study, we showed the possible use of curcumin in the prevention of COVID-19 by targeting the virus replicase protein Nsp9. Turmeric is the principle source of curcumin, and in India it is used as an essential daily ingredient in the food preparation while it has its own antiviral, antifungal, antiallergic properties. Hence, it is preferred over other medicinal compounds in the present study. As curcumin also showed the antiviral properties, the interaction of curcumin and Nsp9 may be useful in understanding the novel SARS Cov-2.  This supports the use of curcumin to reduce the pathological consequences that emerged due to coronavirus infection. So, by targeting the ssRNA of coronavirus at its initial replication stage, through curcumin, when it enters the human is a matter of immediate in-vivo research to possibly overcome the COVID-19 and explore the inhibitory pathways of curcumin to prevent the new coronavirus replication machinery in the human system.

Curcumin: reclaiming the lost ground against cancer resistancee leydig testosterone
Cancer Drug Resistance | February 2021
Curcumin, a polyphenol, has a wide range of biological properties such as anticancer, antibacterial, antitubercular, cardioprotective and neuroprotective. Moreover, the anti-proliferative activities of Curcumin have been widely studied against several types of cancers due to its ability to target multiple pathways in cancer. A large number of reported studies and increasing interest of researchers have reinforced the claim of curcumin being one of the most sought after natural product in the fight against cancer. Curcumin, is a polyphenolic compound of up to 5% present in turmeric. Curcumin as a phytochemical has been widely explored for its therapeutic potential through in vitro and in vivo investigations. It has been shown to possess biological activity against a large spectrum of physiological conditions, which include antioxidant, chemo-protective, anti-diabetic and anti-proliferative activity against cancer cells. Curcumin has shown commendable potential during in vitro and in vivo studies against vrious cancers. It has also been established through clinical trials that curcumin does not show any adverse effect upto a daily dose of 8 g to 12 g. The combinatorial treatment of curcumin has been shown to sensitize the drug-resistant cancer towards existing anticancer drugs and this aspect of combinatorial treatment can be exploited to fully utilize the curative potential of curcumin. In the near future, curcumin may play an important role in chemotherapeutic regimes against different types of cancers.

 

A Review of the Possible Effects of Curcumin in the Treatment of COVID-19
Journal of Military Medicine | February 2021
Curcumin is a natural polyphenolic compound, which could be a potential treatment option for patients with Covid-19. In this study, we review some of the possible effects of curcumin, such as inhibiting virus entry into the cell, inhibiting virus replication and viral protease, as well as modulating some intracellular messenger pathways. To comprehensive literature review, information from an internet search of English language databases PubMed, Scopus, Web of Science and ScienceDirect as well as Persian language databases such as SID using related keywords based on MESH such as COVID-19, SARS-COV-2 , Curcumin and curcuminoid between January 2020 and January 2021 were collected. This review provides some possible effects of curcumin and its mechanisms for the treatment of COVID-19.

Ten Days of Curcumin Supplementation Attenuates Subjective Soreness and Maintains Muscular Power Following Plyometric Exercise
Journal of Dietary Supplements | February 2021
Curcumin has become a popular product used to decrease inflammation and enhance recovery from exercise. Purpose: To determine the effects of curcumin supplementation on delayed onset muscle soreness and muscle power following plyometric exercise. Conclusion: These data suggest curcumin reduces soreness and maintains muscular power following plyometric exercise.

Curcumin: Natural Antimicrobial and Anti Inflammatory Agent
Journal of Pharmaceutical Research International | February 2021
Various studies, conducted as in vitro assays, have revealed different therapeutic applications of curcumin due to its different molecular mechanisms. Findings of the present in vitro study confirmed consideration of curcumin as a natural antimicrobial and anti-inflammatory agent. Test curcumin solutions demonstrated strong antibacterial, antifungal and anti-inflammatory activity. With an increase of curcumin concentration antimicrobial and anti-inflammatory activity increased, which implied that observed activity is dependent upon the concentration of curcumin. In conclusion, the present study emphasises the potential application of curcumin as a natural antimicrobial and anti-inflammatory agent.

Oral supplementation of curcumin for three months reduces p-CS plasma levels in hemodialysis patients, suggesting a gut microbiota modulation
 International Urology and Nephrology | February 2021
Nutritional strategies, such as bioactive compounds present in curcumin, have been proposed as an option to modulate the gut microbiota and decrease the production of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (pCS) and indole-3 acetic acid (IAA). 

Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome
Nutrients | February 2021
Curcumin has been studied to adjunctly treat broad spectrum of disease from type 2 diabetes mellitus to telogen effluvium. Curcumin elicits antidiabetic effects via several mechanisms, including the increase in glycolysis and glycogen synthesis and the decrease in gluconeogenesis in the liver, as well as the increase in glucose uptake, glycolysis, and glycogen synthesis in the skeletal muscle. Curcumin has also been known to reduce plasma cholesterol and triglyceride by increasing the activity of lipoprotein lipase and through mechanisms which alter lipid and cholesterol gene expression. In addition, the anti-inflammatory effects of curcumin have been demonstrated to reduce the oxidative stress in patients with PCOS. Previous literature reveals that curcumin significantly improves fasting blood glucose and triglyceride in patients with metabolic syndrome. In vivo study further demonstrates similar effects in the PCOS model. Curcumin significantly improves fasting glucose, fasting insulin, Homeostasis Model Assessment of Insulin Resistance, and quantitative insulin sensitivity check index. It also significantly improves high-density lipoprotein and total cholesterol. Curcumin may improve glycemic control and lipid metabolism in patients with PCOS and metabolic abnormality without significant adverse effects.  Curcumin may improve glycemic control and lipid metabolism in patients with PCOS and metabolic abnormality without significant adverse effects. Further studies are advocated to investigate the potential effects of curcumin on hyperandrogenism.

Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia
Oncology Reports | February 2021
Curcumin is the main polyphenol component extracted from rhizomes of the plant Curcuma longa, and its therapeutic benefit has been demonstrated in various cancer types, including AML. However, the underlying mechanism is complex and remains poorly understood, as curcumin has multiple targets and is involved in various signaling pathways. Afuresertib has been reported to exert antitumor effects in ovarian cancer, malignant pleural mesothelioma and chronic lymphocytic leukemia. However, to the best of our knowledge, its role in AML has not been previously reported. The present study was the first report that afuresertib could potentially be used for the treatment of AML.In conclusion, the present study demonstrated that curcumin decreased the survival and proliferation of AML cells in vitro, as well as AML cell proliferation in hematopoietic tissue and dissemination .

The Multifaced Actions of Curcumin in Pregnancy Outcome
Antioxidants | February 2021
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), also known as diferuloylmethane, is a polyphenolic yellow substance coming from the rhizomes, the most commonly used plant part, of Curcuma longa Linn (Zingiberaceae family). Curcumin structure is similar to other bioactive non-volatile curcuminoids such as dimethoxy-curcumin and bisdemethoxy-curcumin, differing only for the number of methoxy groups on their aromatic rings. This plant has been used since ancient times for both food and pharmaceutical purposes, showing a variety of beneficial effects in the organism reducing glycemia, hyperlipidemia, insulin resistance  and steatosis in non-alcoholic fatty liver disease (NAFLD). Moreover, due to the cytotoxic effects of curcumin on tumor cells, this compound showed good effects also as an anticancer agent inhibiting tumor proliferation and inducing apoptosis in many cancer types including breast, colon, lung and gastric cancer.  Curcumin has been extensively studied in various fields, showing a wide range of action, including Antioxidant, anti-inflammatory, anti-toxicant, anti-apoptotic, anti-diabetic and immunomodulatory actions, demonstrated by in vitro studies and animal models, suggest the use of this compound as a therapeutic agent in counteracting several pregnancy complications. Inflammation, oxidative stress, Reactive Oxygen Species (ROS) generation and apoptosis are common conditions usually found in almost all of the pathological placental conditions mentioned above; for this reason, curcumin could play a key role in improving pregnancy outcome in these complications. To date, there are many clinical trials studying the efficacy of curcumin in many types of cancer that generally consider curcumin as well tolerated and efficient adjuvant therapy ameliorating the response to chemotherapy and radiotherapy reducing the side effects of these therapies. Clinical effects of curcumin have also been shown in other pathologies. In fact, curcumin improved the severity of patients affected by non-alcoholic fatty liver diseases (NAFLD) disease decreasing the serum concentrations of inflammatory cytokines and chemokines such as TNF-α and MCP-1. Moreover, curcumin intake in women with polycystic ovarian syndrome (PCOS) significantly increased gene expression of PGC1α and activity of the Gpx enzyme reducing oxidative stress. Another clinical trial showed that curcumin was able to improve the symptoms in patients affected by knee osteoarthritis. Beneficial curcumin effects were also found in clinical trials focused on its role in body weight regulation, finding a role for curcumin in reducing BMI and increasing weight loss in addition to decreased serum levels of IL1β, IL-4 and VEGF. Moreover, curcumin administration in two clinical trials showed that curcumin could decrease glucose levels in patients with type 2 diabetes mellitus. Due to its multifaced role in regulating different signaling and the encouraging data obtained in animal models and in vitro studies, curcumin intake during pregnancy could be beneficial in almost all the pregnancy complications mentioned in this review.

Antioxidant Activity of Curcumin Protects against the Radiation-Induced Micronuclei Formation
International Journal of Radiation Biology | February 2021
Curcumin when treated at a dose of 0.5 μg/mL attenuated micronuclei formation after γ-irradiation by inhibiting the formation of radiation-induced free radicals.

Curcumin significantly alleviated cognitive deficits induced by cerebral ischemia.
Brain Research | February 2021
Curcumin ameliorates acute cerebral ischemia-induced cognitive dysfunction in mice. Curcumin promotes hippocampal NSCs proliferation and differentiation into neurons. Curcumin promotes hippocampal neurogenesis through Wnt/β-catenin signaling pathway.

Recent Advances in the Synthesis and Development of Curcumin, its Combinations, Formulations and Curcumin-like Compounds as Antiinfective Agents
Current Medicinal Chemistry | February 2021
Curcumin, a redox-active natural product, has for centuries been used in Asian traditional medicine for the treatment of various diseases. It is known for possessing multiple biological and pharmacological activities. Curcumin has been investigated extensively over the years for its anti-inflammatory, anticancer, antiparasitic, antiviral and antibacterial activities, and no toxicity is associated with the compound. Despite its potency and safety profile, curcumin is still in clinical trials for the treatment of diseases, such as tuberculosis, acquired immunodeficiency syndrome (AIDS), Crohn's disease, colorectal cancer and multiple myeloma, among many others, as it is yet to be qualified as a therapeutic agent.

The effect of curcumin on serum copper, zinc, and zinc/copper ratio in patients with β-thalassemia intermedia: a randomized double-blind clinical trial
Annals of Hematology | February 2021
Due to its significant therapeutic effects, curcumin has led many studies to focus on curcumin.  Curcumin might exert a net protective effect on copper toxicity in thalassemia intermedia patients. The investigation also implicated that curcumin represents an approach to regulating zinc homeostasis and may be useful as a complementary treatment of patients with thalassemia intermedia, especially in patients with zinc deficiency or low serum zinc/copper ratio.

Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
Elife | February 2021
Curcumin is a polyphenol compound that exhibits multiple physiological activities. Curcumin, a polyphenol compound, is extracted from the rhizome of Curcuma longa and has a long history of use in traditional medicines. In in vitro experiments, curcumin has been shown to suppress the aggregation and cytotoxicity of Aβ, αSyn, islet amyloid precursor protein (IAPP), ATTR and prion protein (PrP). In 2001, the first evidence of the efficacy of curcumin against Aβ amyloidosis in a transgenic model mice was reported. Curcumin was found to suppress amyloid deposition in a mouse model of Alzheimer's disease and improve memory function. It was subsequently demonstrated that the amount of amyloid present in TTR-and tau-transgenic mice were reduced by curcumin supplementation. Curcumin is a compound with multiple physiological activities, which includ eanti-oxidation, anti-inflammatory, anti-cancer, lipid metabolism regulation and anti-amyloid properties.

Curcumin and Metabolic Diseases: The Role of Gut Microbiota
Nutrients | January 2021
Turmeric, also known as Curcuma longa L. belongs to Zingiberaceae (or ginger family) and is a golden-colored spice. Curcumin ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is the principle curcuminoid of turmeric used in traditional medicine to cure various kinds of malady, as well as being a food additive and coloring agent in Asian cuisines and in beverage industries. Hewlings and Kalman stated the beneficial effects of curcumin in the treatment of chronic diseases, such as gastrointestinal, neurological disorders, cardiovascular disease, diabetes, and several types of cancer. Enzymes of the large intestine metabolise curcumin, and it is carried out in two phases. In phase-1 metabolism, it yields three metabolites, 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione (tetrahydrocurcumin), 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone (hexahydrocurcumin), and 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol (octahydrocurcumin) under reduction. After that, curcumin and its metabolites subject to conjugation through phase-II metabolism to yield sulfate and glucuronide O-conjugated metabolites. Curcumin metabolites have properties and potency similar to curcumin and exhibit the same physiological and pharmacological properties. It has been stated that curcumin and gut microbiota have bidirectional interactions such as gut microbiota regulation by curcumin and biotransformation of curcumin by gut microbiota.  Carmody et al reported that the biological properties of curcumin depend on the activity of metabolites produced by gut microbiota digestion. The curcumin metabolic pathways by GM include reduction, methylation, demethoxylation, hydroxylation, and acetylation, and the main products are 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione (tetrahydrocurcumin), 3-(4-Hydroxy-3-methoxyphenyl)propanoic acid (dihydroferulic acid), and 1-(4-hydroxy-3-methoxyphenyl)-2-propanol. Furthermore, curcumin can also be metabolized by Pichia pastoris into four major metabolites, include 1,7-bis(4-hydroxy-3methoxyphenyl) heptan-3,5-diol, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl) heptan-3-one, 5-hydroxy-1,7-bis(4-hydroxyphenyl) heptane-3-one, and 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl) heptan-3-one [101,103]. Many GM, such as E. coli, E. fergusonii (ATCC 35469) Blautia sp. (mrg-pmf1), Bifidobacterium (Bifidobacteria longum BB536, Bifidobacteria pseudocatenulaum G4), Lactobacillus (Lactobacillus casei and Lactobacillus acidophilus), Enterococcus faecalis JCM 5803, Pichia anomala, and Bacillus megateriumdcmb-002, are found biologically relevant in the biotransformation and degradation of curcumin.

Curcumin, a traditional spice component, can hold the promise against COVID-19?
European Journal of Pharmacology | January 2021
Curcumin, known for its pharmacological abilities especially as an anti-inflammatory agent, can be hypothesized as a potential candidate in the therapeutic regimen. COVID-19 has an assorted range of pathophysiological consequences, including pulmonary damage, elevated inflammatory response, coagulopathy, and multi-organ damage. This review summarizes the several evidences for the pharmacological benefits of curcumin in COVID-19-associated clinical manifestations. Curcumin can be appraised to hinder cellular entry, replication of SARS-CoV-2, and to prevent and repair COVID-19-associated damage of pneumocytes, renal cells, cardiomyocytes, hematopoietic stem cells, etc. The modulation and protective effect of curcumin on cytokine storm-related disorders are also discussed. Collectively, this review provides grounds for its clinical evaluation in the therapeutic management of SARS-CoV-2 infection.

The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19
Metabolism | January 2021
The antiviral actions of curcumin against multiple viruses (influenza and hepatitis viruses, herpes viruses, human papilloma virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus and other coronaviruses), bacteria and fungi have been established by experimental evidence. Remarkably, recent evidence from in silico studies has demonstrated that curcumin prevents SARS-CoV-2 entry into cells by blocking the viral binding sites and the cell ligands (spike protein, ACE-2 receptors and basigin), downregulating trans-membrane serine protease 2 (TMPRSS-2), and by interfering with viral replication through the interaction with various viral proteins Curcumin (diferuloylmethane) is a natural phenol found in turmeric (Curcuma longa), a member of the ginger family of plants. Curcumin modulates inflammation preventing the subsequent cytokine storm by inhibiting multiple transcription factors such as nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT-3), and downregulating the proinflammatory cytokines, as this has been demonstrated in human macrophages after influenza virus infection. Additionally, curcumin inhibits ACE modulating angiotensin II synthesis and downregulating inflammation, while it also promotes fibrinolysis and the anticoagulation process. Notably, bromelain substantially increases the absorption of curcumin after oral administration. To the best of our knowledge, this is the first report highlighting the significance of bromelain and, most importantly, the potential preventive value of the synergistic effects of bromelain and curcumin against severe COVID-19.

The potential anti-cancer properties of curcumin in liver cancer
In Vivo | January 2021
Curcumin is a polyphenol that exerts a variety of pharmacological activities and plays an anti-cancer role in many cancer cells. Curcumin increased the expression of the GSDME N-terminus and proteins involved in pyrolysis, promoted HspG2 cell pyrolysis and increased intracellular ROS levels. Moreover, inhibition of the production of intracellular ROS with n-acetylcysteine (NAC) improved the degree of apoptosis and pyrolysis induced by curcumin. Curcumin induces HspG2 cell death by increasing apoptosis and pyroptosis, and ROS play a key role in this process.  This study improves our understanding of the potential anti-cancer properties of curcumin in liver cancer.

The role of curcumin, a potent constituent of turmeric in pleiotropic health beneficial effects
 Journal of Biologically Active Products from Nature | January 2021
Curcumin (1,6- heptadiene- 3,5 - dione- 1,7 - bis (4-hydroxy-3-methoxyphenyl) - (1E,6E) or diferuloylmethane), isolated from Curcuma longa, is a highly promising natural compound that has several health benefits.  Supplementation of curcumin provided significant (p < 0.05) protection against HgCl2 induced alterations by ameliorating the levels of ROS, PCO, SA, and -SH in erythrocytes membrane and plasma. Thus, the curcumin protects against HgCl2 induced oxidative stress. It also provides an insight into the role of curcumin, a potent constituent of turmeric in pleiotropic health beneficial effects.

Curcumin, the primary active ingredient in turmeric, reportedly exerts potent antifibrotic effects
Basic & Clinical Pharmacology & Toxicology | January 2021
These results indicate that curcumin is a promising treatment agent for RIF, and its antifibrotic effects may be mediated by the inhibition of NLRP3 inflammasome activity through the regulation of autophagy and protection of mitochondrial function in UUO rats.

Curcumin Suppresses Cell Growth
Life Sciences | January 2021
Curcumin induced Ac-p53 and p21 to suppress cell proliferation.  Curcumin increased p-Akt and attenuated fluoride-mediated apoptosis and DNA damage.  Curcumin suppressed fluoride-induced p-p21 and increased p21 in the nuclear fraction.

Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin
Metabolic Brain Disease | January 2021
Various doses of curcumin attenuated DCAA-induced oxidative stress, inflammation response and impaired synaptic plasticity, while elevating cAMP, PKA, p-CREB, BDNF, PSD-95, SYP levels. Thus, curcumin could activate the cAMP-PKA-CREB signaling pathway, conferring neuroprotection against DCAA-induced neurotoxicity.

Curcumin protects radiation-induced liver damage in rats through the NF-κB signaling pathway
Complementary Medicine and Therapies | January 2021
Curcumin has been demonstrated to exert anti-oxidant, anti-fibrotic, anti-inflammatory, and anti-cancer activities. Our study highlights that curcumin treatment reduces the liver damage caused by radiation through the inhibition of the NF-κB pathway.

Curcumin, as a good all-natural drug for the treatment of IBD, possesses good prospects in clinical application
Molecular Medicine Reports | January 2021
Curcumin is an all-natural compound extracted from plants. It has many biological activities including anti-inflammatory, anti-infective and immune-regulating, and it protects the intestinal mucosa and repairs the function of intestinal tissue. Other similar studies have shown that in the DSS-induced colitis model, curcumin is found to significantly improve intestinal inflammation, repair the intestinal mucosa and inhibit the expression of TNF-α and p38MAPK. Curcumin itself has anti-inflammatory and anti-infective effects. At the same time, curcumin can reduce and inhibit the exudation of neutrophils and macrophages, regulate intestinal immune disorders, reduce intestinal endothelial cell swelling and increase permeability, which further reduces intestinal inflammation. Curcumin can significantly decrease the DAI and SI of the mice with colitis. Curcumin, as a good all-natural drug for the treatment of IBD, possesses good prospects in clinical application.

Effect of Curcumin on Triple-Negative Breast Cancer
AIP Conference Proceedings | January 2021
Curcumin has been reported to efficiently inhibit cancer cell lines, including MCF7, K562, HeLa,and 4T1. Previous study of curcumin on 4T1 breast cancer cells showed that the IC50 values were 93,14 μM. The main mechanisms of action by which curcumin exhibits its 040024-2 unique anti-cancer activity include inducing apoptosis and inhibiting proliferation, invasion, and metastasis of tumors by suppressing a variety of cellular signaling pathways. Several research on various breast cancer cell lines demonstrate the anti-cancer activity of curcumin through the inhibition of NF-κB activity.  Curcumin, the yellow pigment isolated from turmeric, has been reported to suppress NF-κB. Several studies reported that curcumin inhibits NF-κB through inhibition of IKK phosphorylation and inhibition of translocation to the nucleus. Curcumin selectively inhibits NF-κB p105 mRNA expression on 4T1 breast cancer cell line by interacting with the backbone of Ile residue in RH domain region. This study highlights the potency of curcumin to be developed as a chemotherapeutic targeted NF-κB for triple-negative breast cancer in the future.

Curcumin has a certain antagonized effect on cardiac arrhythmia and has potential application prospects
Frontiers in Physiology | January 2021
Curcumin is a natural yellow polyphenolic substance, the main active alkaloid extracted from the rhizome of turmeric, a rhizomatous herbaceous perennial plant belonging to the family Zingiberaceae, which has been used as an antiseptic and antipyretic folk medicine for centuries. Previous researches have shown that curcumin has extensive pharmacological activities and has been put into clinical practice. Increasing evidence showed that curcumin has a protective effect against cardiovascular disease. For instance, curcumin can prevent the development of heart failure by inhibiting p300 histone acetyltransferase activity, antagonized sodium fluoride intoxication in rat heart, prevented isoprenaline (ISO)-induced cardiac hypertrophy, and can have a protective effect against the myocardial infarction injury. In addition, curcumin was reported to prevent the QTc prolongation in ISO-induced myocardial infarction.  Curcumin is also a multi-ion channel blocker that inhibits ICa.L and IKr and preferentially blocks INa.L, shortens APD, suppresses EADs and DADs at the cellular level, prevents I/R-induced arrhythmia at the organ level, and may have potential antiarrhythmic property. Curcumin can prevent the occurrence of arrhythmias after reperfusion, which is beneficial for the recovery of isolated heart suffering from I/R injury.

New evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin
Evidence-Based Complementary and Alternative Medicine | January 2021
Curcumin is the most active component of spice turmeric (also called curry powder), mainly found in turmeric roots (Curcuma longa L.). It has long been studied for its antioxidant, anti-inflammatory, antimutagenic, antimicrobial, and anticancer properties. In the recent years, curcumin has been extensively investigated for its therapeutic value. Its anti-inflammatory effect which is equivalent to that of steroidal and nonsteroidal drugs, e.g., indomethacin and phenylbutazone, is one of the most studied properties. In various inflammation-related chronic illnesses such as cardiovascular disease, cancer, diabetes, and obesity, curcumin has shown good therapeutic effects. The present study shows that curcumin suppresses aldosterone-induced CRP generation in VSMCs by interfering with the ROS-ERK1/2 signaling pathway. These results reveal a mechanism through which curcumin represses inflammation and confers cardiovascular protection. Our findings further confirm the anti-inflammatory and cardiovascular protective effects of curcumin and suggest its potential clinical use in cardiovascular inflammation.

Curcumin may be an attractive natural candidate for further investigation and development in the quest for Parkinson's disease therapeutics
International Journal of Molecular Sciences | January 2021
The polyphenolic ingredient of dietary turmeric (Curcuma longa), curcumin, has attracted attention due to its multiple benefits to patients with various diseases including Parkinson's disease. Several studies have demonstrated that curcumin treatment significantly inhibits the toxin-induced loss of dopaminergic neurons in both cultured cells and animal models. Curcumin was found to exert neuroprotective effects mediating anti-oxidant, anti-inflammatory, and anti-apoptotic properties and improve neurological functions in various animal models of Parkinson's disease. Our results demonstrated that intragastric curcumin treatment (200 mg/kg) significantly improved the abnormal motor behavior and offered neuroprotection against the reduction of dopaminergic neurons, as determined by tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra and caudoputamen. In conclusion, this study demonstrates that curcumin has a neuroprotective effect in a 6-hydroxydopmine (6-OHDA) rat model of PD via an α7-nAChR-mediated mechanism. The findings of the present study demonstrate that curcumin improves the survival of TH striatal fibers and neurons in SNpc and diminishes abnormal turning behavior in a 6-OHDA-induced rat model of PD. In the present study, abrogation of the protective effects of curcumin by pretreatment with MLA, an α7-nAChR-selective antagonist, clearly demonstrates that neuroprotective effects of curcumin are mediated by α7-nAChRs. Our findings clearly demonstrate that α7-nAChRs may be an attractive therapeutic target for PD and curcumin appears to be the first agent of natural origin to modulate α7-nAChRs in PD. Integrating our earlier observation that curcumin acts as a type II PAM of α7-nAChRs and potentiates receptor function by significantly decreasing desensitization, it is apparent that the PAM action of curcumin on α7-nAChRs exerts beneficial effects in mediating neuroprotective effects. Time-tested safety and neuroprotective efficacy of curcumin and preliminary clinical success of agents targeting nicotinic receptors in Parkinson's disease.

Curcumin and NAC may be effective against noise-induced hearing loss
Indian Journal of Otolaryngology and Head & Neck Surgery |  January 2021
We investigated the effectiveness of N-acetyl cysteine (NAC) and curcumin, which have known antioxidant and anti-inflammatory effects, in reducing acoustic trauma. There was a statistically significant difference in the third measurements in both groups 2 and 3, possibly due to curcumin and NAC treatment. This study showed that curcumin and NAC may be effective against noise-induced hearing loss.

Curcumin exhibits beneficial effect on bone fracture healing
Medical Science Monitor | January 2021
Curcumin has been used for a very long time in traditional medicine because of several pharmacological properties. Multiple properties of curcumin include its role as an anti-inflammatory, antioxidant, and anti-fibrotic agent. Additionally, studies have shown tumor growth inhibitory effect and myocardial injury protecting property of curcumin. Although studies on the use of curcumin in bone trauma treatment are limited, reports suggest that curcumin may have a positive effect in bone remodeling. The current study investigated curcumin for bone trauma treatment in a rat model and evaluated the related mechanism. Curcumin activates autophagy and inhibits mTOR activation in bone tissues of rats with trauma. The curcumin promoted myeloid-derived suppressor cell (MDSC) proliferation and increased expansion of MDSCs in a rat model of trauma. Therefore, curcumin may have beneficial effect in patients with bone trauma and should be evaluated further for development of treatment.

A novel application of curcumin in tumor therapy
Archives of Biochemistry and Biophysics | January 2021
Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress. Curcumin is a natural polyphenol derived from turmeric, which has been shown to inhibit the growth of many types of tumor.  We found that curcumin induced the apoptosis and cell cycle arrest of CAFs, which is mainly caused by the ROS-mediated endoplasmic reticulum stress pathway. Our study suggests that curcumin selectively inhibits prostate-CAFs by inducing apoptosis and cell cycle arrest in G2-M phase, indicating a novel application of curcumin in tumor therapy.

Curcumin may be an alternate to antimicrobial drugs for the therapeutic management of endometritis
Molecular Biology Reports | January 2021
Curcumin inhibited the basal and LTA+LPS induced production of PGE2 and upregulation of PIC production. It was apparent that LPS, but not LTA, is a potent stimulator of PGE2 from the bubaline endometrial stromal cells. Curcumin downregulated the expression of LPS and/or LTA induced PICs and PGE2 and may be an alternate to antimicrobial drugs for the therapeutic management of endometritis.

Curcumin represents a promising therapy for Diabetes mellitus induced cognitive impairments and memory deficits
Neurobiology of Disease | January 2021
Curcumin, derived from the rhizome of Curcuma longa Linn, is a bright yellow spice that shows strong anti-inflammatory, anti-oxidant, and anti-tumor activities.ibiting neuroinflammation. We demonstrated that curcumin attenuated DM/CCH-induced cognitive defcits and hippocampal neuronal damage in rats, and that its underlying mechanisms were associated with inhibiting neuroinflammation, regulating the TREM2/TLR4/NF-κB pathway, suppressing excessive apoptosis, and mitigating NLRP3-dependent pyroptosis. These findings suggest that curcumin may be useful as a pharmacological strategy for ameliorating Diabetes mellitus /CCH-induced memory deficits.

Curcumin exhibited renoprotective, antioxidant, anti-inflammatory properties, especially curcumin exerted the most pronounced effect as an anti-inflammatory and anti-apoptotic reflecting its powerful effect against bacteria and sepsis-induced kidney injury
Future Journal of Pharmaceutical Sciences | January 2021
Curcumin a polyphenol extracted from turmeric gained interest as a potentially safe and inexpensive treatment for kidney diseases. Inflammatory markers were greatly reduced by both curcumin and propolis, only curcumin pretreatment attenuated NF-kB activation in kidney tissue of septic rat.

The protective effect of curcumin on ACR-intoxicated brains
BMC Pharmacology and Toxicology | January 2021
Curcumin is well known for its classic and strong anti-oxidative and anti-inflammatory activities. As the most active constituent in turmeric, a common spice, with a strong safety record, curcumin has been considered to be a potential natural neuroprotective agent under limelight. Based on its known antioxidant, anti-inflammatory and anti-apoptosis activities, curcumin has been shown to protect the neurons against cerebral ischemia-reperfusion injurye neuroprotective effect of curcumin in an ACR model of neurotoxicity in an insect species, Drosophila melanogaster. A recently published study reported that curcumin would exert a protective effect against ACR-induced spatial memory impairment in rats. The phenolic structure in curcumin confers electron-capturing properties, which destabilize ROS, explaining the well-accepted antioxidant effects. Curcumin alleviated the augmented production of MDA and the reduction of antioxidant capacity induced by ACR, thus might play a role in the detoxification of reactive oxygen species generated by ACR.  Curcumin could improve the ACR-induced neuroinflammation, which was in accord with its proven anti-inflammatory property.

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?
Nutrients | January 2021
Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries.  The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. Curcumin, a compound extracted from the rhizome of Curcuma longa, has been extensively studied in light of a wide range of properties, including anti-inflammatory, antioxidant, anti-toxicant, antiapoptotic, immunomodulatory, neuroprotective, hepatoprotective, antiangiogenic, anti-hypertensive, and antidiabetic activities, emerging as a candidate therapeutic agent for several diseases. Curcumin, also called diferuloylmethane, is a lipophilic polyphenol extracted from the rhizome of Curcuma Longa (commonly known as turmeric). It has been widely used in traditional Indian and Chinese medicine for thousands of years. The pharmacological effects of turmeric have been attributed mainly to curcuminoids, comprising curcumin and two related compounds, demethoxycurcumin and bisdemethoxycurcumin, which are contained in commercial curcumin. Curcumin is a potent anti-inflammatory and antioxidant agent that exerts a myriad of biological activities by influencing multiple signaling pathways. Curcumin is able to interact with a large number of molecular and cellular targets and regulates gene expression also by modulating epigenetic modifications (i.e., DNA methylation, histone modification, and microRNA expression). This compound, by mutually interacting with intestinal microflora

Curcumin extract eased pain, stiffness and physical function in those with osteoarthritis of the knee
New York Times | December 2020
Turmeric comes from the root of a plant in the ginger family, Curcuma longa, and contains a chemical compound, curcumin, that has long been used in traditional Chinese and Indian medicine. In a 12-week randomized, double-blind, placebo-controlled trial, researchers assigned 70 people with symptomatic knee osteoarthritis to take either two capsules a day of a Curcuma longa extract or two capsules of an identical-looking placebo. They found that pain, stiffness and physical function all improved significantly more in those who took the curcumin extract than in those who used the placebo.

Neonatal curcumin treatment restores hippocampal neurogenesis and improves autism-related behaviors in a mouse model of autism
Psychopharmacology | December 2020
Curcumin has been indicated to be neuroprotective against neurological and psychological disorders. Neonatal curcumin treatment improved autism-related symptoms in BTBR mice, enhancing sociability, reducing repetitive behaviors, and ameliorating cognitive impairments. Furthermore, the suppression of hippocampal neurogenesis in BTBR mice was greatly rescued after neonatal curcumin treatment, leading to an increase in neurogenic processes and an increase in NPC proliferation concomitant with an expansion of the NPC pool on P8, and NPC differentiation towards the neuronal lineage was promoted in the DG of BTBR mice on P24. Our findings suggest that neonatal curcumin treatment elicits a therapeutic response through the restoration of hippocampal neurogenesis in BTBR mice and thus may represent a promising novel pharmacological strategy for ASD treatment.

Curcumin cooperates with anticancer drugs
The International Journal of Biochemistry & Cell Biology | December 2020
Curcumin inhibit Lactate-induced onset of chemoresistance through modulation of HCAR-1.  Curcumin modulates Chromatin condensation and acidification of extracellular milieu of cancer cells.

Can Turmeric Help With Knee Arthritis
San Diego Orthobiologics | December 2020
Turmeric, a spice from South Asia derived from the Curcuma longa root, has been used as a medicine for nearly 4000 years. Recent studies have shown that turmeric may help to relieve joint pain caused by arthritis because the active ingredient, curcumin, is now known to have anti-inflammatory properties. Curcumin has been shown to have similar efficacy to diclofenac, a non-steroidal anti-inflammatory drug, with fewer side effects. Similar improvements in pain severity and function were seen with curcumin and diclofenac in a randomized, controlled clinical study of 139 patients with knee osteoarthritis. Nineteen patients in the diclofenac group (and none in the curcumin group) required anti-ulcer medications at 28 day followup. Curcumin has also been shown to have a strong antioxidant capacity. In a randomized double-blind placebo-controlled trial, patients with mild-to-moderate knee osteoarthritis were given the curcuminoid and were compared to a group that received a placebo for 6 weeks. Researchers measured the levels of enzymes known to influence inflammation (e.g. superoxide dismutase (SOD) and malondialdehyde (MDA)). The treatment group showed significant changes in these enzymes suggesting that short-term supplementation with curcumin decreases oxidative stress.

5 Good Things About Turmeric
MD News Daily | December 2020
A report about turmeric indicates that study in the European Review for Medical and Pharmacological Studies, Frontiers in Pharmacology, and Endocrine, Metabolic & Immune Disorders Drug Targets associate curcumin with weight loss and reduction in body mass index or BMI. Healthy cooking expert and registered dietitian Patricia Bannan said, while increasing our turmeric intake alone is not a great tactic in losing weight, it may contribute to the mitigation of inflammation linked to obesity and offer a slight boost in fat burning.   Curcumin may help protect from inflammation, and inflammation may help in fighting depression. A 2019 meta-analysis of 10 studies of curcumin and depression published in Critical Reviews in Food Science and Nutrition proposed that it could alleviate depression and anxiety symptoms. Experts say the most available study specifies that curcumin may help lessen the depression symptoms in individuals who are already using an antidepressant. Previous studies on animals propose that there might be a link between the inflammation-calming action of curcumin in turmeric and cancer. Specifically, Bannan said, curcumin is believed "to have antioxidant properties." Meaning, it may reduce both swelling and inflammation. Nevertheless, research on animals does not always translate humans. Research for curcumin continues, as well as its effect on cancer in people. A study finds people living in India have lower rates of developing Alzheimer's disease than those living in the United States and Europe. The reasons for the difference, the study authors said, are complex and possibly because of several different factors. Typically, turmeric is used in Ayurveda, a holistic healing mechanism that originated in India thousands of years back and remains famous to date. Turmeric is also prominent in Indian cuisine, bringing out the question of whether it is possible that this spice can contribute to the prevention or delay of onset of Alzheimer's. The jury, according to the study, is still out. However, one theory presents, curcumin may contribute to the inhibition of plaques that other studies have linked to "neuron impairment in the brain. Based on a report by the Centers for Disease Prevention and Control, more than 100 million adults in the US have developed either prediabetes or diabetes. A study on curcumin, which the Journal of Nutrition & Intermediary Metabolism published, proposes that it can function as a "hypoglycemic agent," reducing and helping regulate blood sugar levels in people who have type 2 diabetes, CDC said.

Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials
Nutrition Reviews | December 2020
Chronic inflammation is a major contributor to the development of noncommunicable diseases. Curcumin, a bioactive polyphenol from turmeric, is a well-known anti-inflammatory agent in preclinical research. Clinical evidence remains inconclusive because of discrepancies regarding optimal dosage, duration, and formulation of curcumin. These findings provide evidence for the anti-inflammatory effects of curcumin and support further investigation to confirm dose, duration, and formulation to optimize anti-inflammatory effects in humans with chronic inflammation.

Quinacrine and curcumin synergistically increased breast cancer stem cells death
Cancer Biology and Therapeutic Oncology | December 2020
Curcumin and QC synergistically inhibited the proliferation, migration and invasion of CSCs enriched side population (SP) cells of cigarette smoke condensate induced breast epithelial transformed (MCF-10A-Tr) generated metastatic cells. Curcumin + QC combination increased the DNA damage and inhibited the DNA repair pathways in SP cells. Uptake of QC increased in Curcumin pre-treated SP cells and this combination inhibited the ABCG2 activity by the reduction of ATP hydrolysis in cells. In vitro DNA binding reconstitution system suggests that QC specifically binds to DNA and caused DNA damage inside the cell. Decreased level of ABCG2, representative cell survival and DNA repair proteins were noted after Curcumin + QC treatment in SP cells.

Longevity-Promoting Herb
Well and Good | December 2020
In 2018, Dr. Small authored a small double-blind study showing that taking two 90 mg curcumin supplements daily for 18 months improved memory and attention in older adults with mild memory problems. “We did find it has a significant effect…compared to placebo,” says Dr. Small, who is currently expanding the research to a much larger sample size across the U.S. While he’s not sure exactly how curcumin works to boost brain health, “my best guess is it’s the reduction in inflammation,” he says. Robinette points out that turmeric has been called a “natural immunomodulator,” or a substance that helps keep the immune system in check by boosting immunity when you need it and tamping it down to prevent excess inflammation involved in many chronic conditions. Some research suggests that turmeric could potentially even play a role in preventing and treating cancer, cardiovascular disease, metabolic conditions, neurological disease, and skin diseases. Although it certainly doesn’t hurt to enjoy more foods with turmeric, you’ll need to pop a curcumin supplement to get the full health benefits of the spice. “For therapeutic purposes, you want to take higher doses,” says Robinette. Try to take the supplement when you eat your meals, preferably with fat (like fatty fish or nuts) to increase the bioavailability of curcumin.

Antitumor effects of curcumin in pediatric rhabdomyosarcoma
International Journal of Oncology | December 2020
Curcumin (CUR) is a promising drug in complementary oncology with few side effects but proven efficacy in various adult oncological entities. The present study analyzed the effects of curcumin on pediatric (RMS) cell lines in vitro. Curcumin decreased cell viability in all assessed RMS cell lines in a concentration‑dependent manner with IC50=14‑20 µM. Curcumin enhanced the effects of the cytotoxic drugs VCR or DAC, and led to reduced migration and increased cell apoptosis. In combination with PDT, curcumin decreased the cell viability in minute quantities with up to a 10‑fold lower IC50 than without PDT. Curcumin effectively inhibited the malignant properties of pediatric RMS cells and should be focused on as a useful additional agent in standard chemotherapy of RMS in children.

Curcumin in antidepressant treatments
Basic & Clinical Pharmacology & Toxicology, December 2020
Curcumin, a natural compound derived from the herb Curcuma longa, exhibits a wide range of pharmacological properties and has been considered a potent antidepressant drug with diverse mechanisms including monoaminergic imbalances (associated with serotonin, dopamine, noradrenaline and glutamate), effect on neurotransmitters, neuroprogression, the hypothalamic‐pituitary‐adrenal (HPA) axis disturbances, dysregulated inflammation and immune pathways, oxidative and nitrosative stress, and mitochondrial disturbances. In this review, multiple potential mechanisms of curcumin for treating depression demonstrated in either animal or human studies are summarized.

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytes in Vitro
Journal of Biological Chemistry, December 2020
Inflammatory processes play essential roles in the pathogenesis of tendinitis and tendinopathy.  Results demonstrate, for the first time, a potential role for curcumin in treating tendon inflammation.

Curcumin in Depression: Potential Mechanisms of Action and Current Evidence
Frontiers in Psychiatry | March 2021
Curcumin is the main active component in the spice turmeric that has been used for centuries in Ayurvedic medicine to treat a variety of conditions, including anxiety and depressive disorders. In the past decades, curcumin has drawn researchers' attention and displays a broad range of properties that seem relevant to depression pathophysiology. Curcumin has displayed, in a number of studies, a potency in modulating neurotransmitter concentrations, inflammatory pathways, excitotoxicity, neuroplasticity, hypothalamic–pituitary–adrenal disturbances, insulin resistance, oxidative and nitrosative stress, and endocannabinoid system, all of which can be involved in MDD pathophysiology. To date, a handful of clinical trials have been published and suggest a benefit of curcumin in major depressive disorder. With evidence that is progressively growing, curcumin appears as a promising alternative option in the management of major depressive disorder. Turmeric (Curcuma longa) is a yellow spice, part of the ginger family (Zingiberacear). It has been empirically used for centuries in Ayurvedic and traditional Chinese medicine in a wide variety of diseases and conditions. Research conducted in the last half century has revealed that the active compounds of turmeric were curcuminoids, which are polyphenolic pigments that give turmeric its yellowish color. Curcumin is the primary curcuminoid and main active component in turmeric and the compound for which most studies have been done. In the past decades, there has been a surge of interest in curcumin as evidence about its efficacy in a wide variety of diseases is growing, including cardiovascular, autoimmune, and neurodegenerative diseases as well as diabetes and cancers. Thus, curcumin displays a broad range of properties that are relevant in the pathophysiology of depression. It has been demonstrated to possess an antidepressant activity in various animal models as well as in clinical trials. A dozen randomized controlled clinical trials have indeed been conducted, altogether suggesting that curcumin may be effective as a treatment (or adjunct treatment) of depression via multiple mechanisms of action.

Anticancer properties of curcumin: a novel natural inhibitor of rDNA transcription
Cell Cycle | November 2020
Curcumin treatment impairs the assembly of the RNA polymerase I preinitiation complex at rDNA promoters and represses rDNA promoter activity, which leads to the decrease of rRNA synthesis. In addition, curcumin treatment stimulates autophagosome formation and promotes autophagic degradation in cells. Mechanistically, curcumin inactivates the mechanistic target of rapamycin complex 1 (mTORC1), the upstream regulator of rDNA transcription and autophagy induction, by inhibiting mTOR lysosomal localization. Functionally, curcumin treatment inhibits protein synthesis, cell growth and cell proliferation. Taken together, these findings identify curcumin as an effective inhibitor of rDNA transcription and provide novel mechanisms for the anticancer properties of curcumin.

Reduce Your Lifetime Risk of Breast Cancer
The Beet | November 2020
Curcumin lowers inflammation, which can lower the risk of breast cancer. Curcumin, the main active ingredient in turmeric, is known for relieving inflammation and pain but also for having an effect on lowering the risk of breast cancer. A study found "curcumin has chemopreventive and antitumoral activities against some aggressive and recurrent cancers," the study said. Another study found curcumin not only stops tumor growth but also prevents malignant cancers from spreading: The "anticancer effect" of curcumin relates to the fact that it appears to half "cell cycle and proliferation," as well as "cancer spread and angiogenesis," the study says, which is how the body supplies new blood vessels to a tumor.

Curcumin against Prostate Cancer: Current Evidence
Biomolecules | November 2020
The available in vitro studies have shown that curcumin is able to inhibit viability, proliferation, survival, migration/invasion, and adhesion of various human prostate cancer cells. Curcumin inhibited both androgen-sensitive and -insensitive prostate cancer cells by targeting a number of signaling cascades responsible for regulating cellular function. The antiproliferative, antisurvival, and antimigratory effects of curcumin in prostate cancer cells may be due to the inhibition of the Akt/mTOR, Ras/MAPK signaling pathways, decreased NF-κB activation, enhanced proapoptoptic caspase and PARP cleavage, and the inhibition of members of the antiapoptotic Bcl-2 family of proteins. Curcumin was also able to induce cell-cycle arrest and enhance autophagy in various prostate cancer cell lines. The available in vivo studies have shown that curcumin administration is able to inhibit the growth/volume, formation, development, proliferation, and angiogenesis of prostate cancer tumors while promoting apoptosis. These effects were observed in mice xenografted with both androgen-sensitive and insensitive prostate cancer cells. Curcumin’s inhibition of prostate tumor growth and progression may be due to its inhibition of Akt expression/activation, decreased NF-κB activation, inhibition of the anti-apoptotic proteins Bcl-2 and Bcl-xL, increased expression of the proapoptotic proteins Bax and Bak, and enhanced PARP and caspase expression. These findings from in vivo studies are in agreement with those from the in vitro studies. The downregulation of cell proliferation, paired with the enhanced activity of programmed cell death both in vitro and in vivo, render curcumin an ideal candidate for the development of novel anticancer pharmaceutical agents providing fewer detrimental effects due to its low toxicity.

Metabolites of curcumin and their therapeutic effects
Cell | November 2020
Curcumin, a secondary metabolite from the turmeric plant is one of the most promising natural products, which has been studied extensively for decades. It has demonstrated several pharmacological activities in vitro and in vivo. Several diverse therapeutic effects have shown to be exhibited by reduced metabolites of curcumin such as antioxidant, anti-cancerous, anti-inflammatory and immunoregulatory activities. Curcumin is a natural polyphenolic compound which forms a majorcomponent of rhizomes from dietary spice turmeric (Curcuma longaa plant belongs to Zingiberaceae family. It is commonly used as a flavouring agent in various foods and also as a traditional medicinal agent. In several studies, curcumin have shown a diverse range of pharmacological effects like, anti-cancer, anti-oxidation, anti-inflammatory, anti-bacterial activities, free radical scavenging and anti-depression. Owing to these pharmacological effects, curcumin has therapeutic potential over a variety of human diseases such as cancer, cardiovascular disease, diabetes, arthritis, Alzheimer's disease, AIDS, neurological diseases, and Crohn's disease. The importance of curcumin can be estimated by the fact that thirty-seven cases of clinical trials of curcumin  were completed by December 2017 and two cases FDA (Food and Drug administration) clinical phase 4 trials were completed.

Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies
Phytotherapy Research | November 2020
Curcumin is a natural phytochemical with anti‐inflammatory and anti‐neoplastic characteristics. Our results demonstrated that curcumin ameliorated the pneumonia‐induced lung injury, mainly through a reduction of the activity and infiltration of neutrophils and the inhibition of inflammatory response in mouse models. Curcumin ameliorates the severity of pneumonia through a reduction in neutrophil infiltration and by amelioration of the exaggerated immune response in preclinical pneumonia models.

Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review
Journal of Medicinal Food | November 2020
The results of the randomized clinical trials (RCTs) showed promising results with the use of curcumin in the therapeutic approach of both UC and CD patients. Some meta-analyses show controversial results, possibly due to the presence of bias in the included studies. The actions of curcumin are achieved by several mechanisms, such as reducing the expression of interleukin (IL)-1, IL-6, IL-12, and tumor necrosis factor-α. Moreover, it reduces the levels of reactive oxygen species, such as superoxide anions and malondialdehyde.

Evaluation of Cognitive Performance following Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity
The Journal of Nutrition | November 2020
Curcumin improved CVR in a working memory test and, in males only, performance of a verbal memory test compared with placebo.

Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics
Seminars in Cancer Biology | November 2020
Curcumin and resveratrol modulate the apoptosis and autophagy mediated cell death pathway for chemoprevention.  Curcumin and resveratrol reduce cytotoxicity and exhibit chemo-protection during chemotherapy.  Drug synergism and advanced drug delivery systems of curcumin and resveratrol enhances the anticancer efficacy.  Enhanced pharmacokinetics and pharmacodynamics are responsible for better pre-clinical and clinical application.

COVID‐19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?
Nordic Pharmacological Society | November 2020
Curcumin is the effective ingredient of turmeric, sometimes used as a painkiller in traditional medicine. Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF‐kBERK1,2, AP‐1, TGF‐β, TXNIP, STAT3, PPARγ, JAK2‐STAT3, NLRP3, p38MAPK, Nrf2, Notch‐1, AMPK, TLR‐4 and MyD‐88. Due to anti‐inflammatory and anti‐inflammasome properties without any special side effects, curcumin can potentially play a role in the treatment of COVID‐19 infection along with other drug regimens.

Curcumin Suppresses Tumorigenesis via Promoting SLC1A5-mediated Ferroptosis in Breast Cancer
Surgical Oncology | November 2020
Curcumin treatment significantly suppressed breast cancer cell viability in a dose-dependent manner. Moreover, curcumin triggered ferroptosis by enhancing the levels of lipid ROS, lipid peroxidation end-product MDA accumulation, and intracellular Fe2+. Mechanistically, curcumin administration impeded tumor growth via upregulating solute carrier family 1 member 5 (SLC1A5)-mediated ferroptosis in breast cancer. In vivo experiments showed that curcumin could effectively hamper the growth of tumors without noticeable side effects. Conclusion: We demonstrated that curcumin exhibits anti-tumorigenesis activity in breast cancer by promoting SLC1A5-mediated ferroptosis, providing a potential therapeutic agent for the treatment of breast cancer.

Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells
Technology in Cancer Research & Treatment | November 2020
Curcumin inhibited sE-cad expression and reversed EMT induced by radiation. Furthermore, curcumin suppressed sE-cad-enhanced A549 and A549R cell migration and invasion. Curcumin inhibited MMP9 expression, and silencing MMP9 suppressed sE-cad expression. Taken together, we found a nonclassic EMT phenomenon induced by radiation. Curcumin inhibits NSCLC migration and invasion by suppressing radiation-induced EMT and sE-cad expression by decreasing MMP9 expression.

Can concomitant use of zinc and curcumin with other immunity‐boosting nutraceuticals be the arsenal against COVID‐19?
Phytotherapy Research | November 2020
Curcumin is a natural bioactive polyphenolic compound isolated from the dried powder of Curcuma longa rhizomes, commonly known as turmeric (Haldi in Hindi), and widely used worldwide for cooking. Ayurveda mentioned the use of turmeric for numerous therapeutic purposes like blood coagulation to immune stimulation. An array of systemic antioxidant properties has been attributed to curcumin‐containing nutraceuticals. For example, it exerts an anti‐inflammatory action in arthritis and inflammatory bowel diseases, reduces lipid levels in cardiovascular diseases, and addresses oxidative stress in skin disorders. Curcumin has an established track record as an antiviral agent against several viruses like Influenza Type A, Hepatitis A, Zika, HIV, etc. The mode of action of curcumin includes—inhibition of viral entry into cells, suppression of viral replication, stimulation of interferons (IFNs) and other cytokines, and inhibition of viral protein expression. In silico studies have also revealed that curcumin binds directly with the receptor‐binding domain of the viral spike protein (involved in host cell binding) and the cognate host cell receptor, angiotensin‐converting enzyme‐2 (serves as a medium of viral entry), of SARS‐CoV‐2 virus. Moreover, curcumin has been reported to inhibit the release and suppress numerous cytokines like IL‐1β, IL‐6, IL8, TNFα, MCP‐1, etc. When investigated in various viral infections set‐up, the mode of cytokine suppression by curcumin can be correlated with clinical improvement in conditions associated with cytokine storm. Following the suggested interaction with these key components of the viral lifecycle and immune system, it is apparent that curcumin could prevent the COVID‐19 infection. Moreover, in recent years, blood coagulation properties of curcumin (by inhibiting platelet aggregation, cyclooxygenase pathway, and blocking of calcium signaling) have been utilized in designing various materials and devices. As the SARS‐CoV‐2 coronavirus infection can be associated with a disseminated intravascular coagulopathy, hence curcumin can be an effective agent against this pathological condition.

Turmeric, Curcumin, and Curcuminoids: A Dermatologic Review
PracticalDermatology.com | November 2020
Research has shown that curcumin, one of the active compounds of turmeric, exhibits anti-inflammatory, antimicrobial, antioxidant, anti-nociceptive, and antineoplastic properties. Specifically, curcumin has been shown to potentially play a role in type 2 diabetes mellitus by reducing lipid levels, in metabolic syndrome by increasing insulin sensitivity and production, in cardiac diseases by lowering C reactive protein, and even in major depressive disorder via its anti-inflammatory effects. Currently, it is being studied as a possible treatment for Alzheimer’s disease. Curcumin is thought to downregulate inflammatory targets, such as lipoxygenase, cycloxygenase-2, and inducible nitric oxide synthase. It has also been shown to inhibit many inflammatory cytokines, including TNF, IL-1, 2, 6, 8, and 12. Moreover, curcumin has been hypothesized to suppress NF-KB, which is a transcription factor that controls cycloxygenase-2 and inducible nitric oxide synthase and regulates cellular proliferation. These findings make curcumin a suitable candidate for treating skin conditions that are characterized by derangement of the inflammatory response.

The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine
International Union of Biochemistry and Molecular Biology | November 2020
Curcumin, the main polyphenolic compound derived from Curcuma longa, is mainly known by its anti‐inflammatory and antioxidant properties. There are in vitro and in vivo reports revealing the preventive and ameliorating effects of curcumin against pregnancy complications. Here, we aimed to seek mechanisms underlying the modulatory effects of curcumin on dysregulated inflammatory and oxidative responses in various pregnancy complications.

Effect of topical curcumin on the healing of major oral mucosal ulceration
Eurasian Journal of Biosciences | November 2020
Curcumin was a turmeric extract, its multifaceted biological effects such as, anti-inflammatory, anti-oxidant, anti-carcinogenic and anti-infectious effects.  Results: The present study showed that the curcumin treatment reduce mucosal ulcer area from the 3rd day till 7th day and improved ulcer healing at 14th day by activation of epithelial cell, inhibit inflammatory cells, enhance endothelial cells and promote fibroblast cells.

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis
Annals of Internal Medicine | November 2020
Curcumin was more effective than placebo for knee pain but did not affect knee effusion–synovitis or cartilage composition.

Therapeutic Effects of Curcumin Against Colorectal Cancer
Phytochemicals Targeting Tumor in Gastrointestinal Cancer, October 2020
Curcumin is a product of the plant, Curcuma longa, which exhibits anti-inflammatory, anti-infectious, and anticancer activities. A wide variety of evidences from numerous studies demonstrated that curcumin prevents carcinogenesis, modulates signaling, inhibits angiogenesis and other critical aspects linked to cancer cell survival and proliferation, and induces chemopreventive and anticancer activity against colorectal cancer. Curcumin also showed improved efficacy of chemotherapeutic agents in combination studies.

Antitumoral Effects of Curcumin (Curcuma longa L.) on Neuroblastoma Cell Lines
Complementary Medicine Research, October 2020
Overall survival of high-risk neuroblastoma patients is still poor, emphasizing the need for novel therapeutic options. There is evidence for anti-cancer properties of the herbal substances thymoquinone and curcumin. Overall, lower IC50 values could be calculated for curcumin (3.75–7.42 µM) than for thymoquinone (5.16–16.3 µM). Decreased proliferation and increased apoptosis rates were observed under treatment. Conclusions: Both substances showed anti-tumoral properties on neuroblastoma cell lines and should be further investigated as therapeutic agents.

Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes
The Journal of Nutritional Biochemistry, October 2020
Curcumin protects against T1DM-induced nephropathy. Mechanism of protection involves inhibition of oxidative stress, inflammation, and fibrosis. Curcumin seems to act by inhibiting PKC-induced activation of Psch66.

Curcumin an aid to Cardiovascular diseases
Financial Express, October 2020
Curcumin plays a very important role in protecting your heart from these cardiovascular diseases because the antioxidants in curcumin have been shown to attenuate adriamycin-induced cardiotoxicity and may prevent diabetic cardiovascular complications. The anti-thrombotic, anti-proliferative, and anti-inflammatory effects of curcumin and the effect of curcumin in decreasing the serum cholesterol level may protect against the pathological changes occurring with atherosclerosis.

Health Benefits Of Turmeric
Maine News Online, October 2020
Turmeric is a readily available and natural remedy for chronic inflammation. It contains curcumin, which has excellent anti-inflammatory properties. The curcumin even makes turmeric more effective than most anti-inflammatory drugs. And besides, it is natural, accessible, pocket friendly, and has no known side effects. What curcumin does is to suppress the molecules responsible for the inflammation. By so doing, it will protect you from chronic diseases.The curcumin in turmeric, according to research, can lower oxidative stress. It serves as antioxidants and has the power to stimulate the body’s antioxidant enzymes. Consequently, this strengthens one’s immune system.What makes curcumin beneficial for your heart health is improving the endothelium (blood vessels’ lining) function. Curcumin’s anti-inflammatory and antioxidant functions also make it useful for maintaining your heart health.Studies have identified curcumin, which is present in turmeric, as a potent herb in cancer treatment. The studies also indicated that curcumin’s effect is the same in all cancer types. What curcumin does is that it fights cancer at the molecular level. It prevents the growth, spread, and development of the disease in the body. According to a study conducted by the MD Anderson Cancer Center, researchers discovered that curcumin inhibits melanoma cells’ growth and even cause tumor cells to eliminate themselves. Curcumin can increase BDNF levels in the brain. With this action, it can encourage the reversal or delay of brain-related decline or diseases. Studies have been conducted to confirm curcumin’s potency in arthritis treatment, and the outcome showed great promise. In one of the studies, curcumin proved to be more potent than most anti-inflammatory medication used in treating rheumatoid arthritis. As documented in another study, curcumin’s use led to improvements in various symptoms most arthritis patients had. Turmeric’s effect on mental health has been well-documented. One of its constituents, curcumin, proves useful in the fight against depression. In one study involving 60 participants who had depression, the participants were divided into three groups. The first group was given an antidepressant; the second group had a gram of curcumin, while the third had both the antidepressant and curcumin. After six weeks, curcumin’s effect was similar to the antidepressant. Turmeric’s curcumin has shown promising antiviral properties. It can take down specific viruses, as reported by the Microbiology Society. In a study conducted, curcumin prevented TGEV (Transmissible gastroenteritis virus) from infecting cells. In high dosage, curcumin was able to eliminate the virus particles.

Effect of Curcumin on Testis in Mice with Ehrlich Ascites Tumor
New Trends in Medicine Sciences, October 2020
Findings clearly suggested that antioxidant parameters (except CAT and GPx) had higher value in animal models treated with 25 and 50 mg curcumin groups associated to tumor control group. There was a statistically noteworthy variance between the groups in all parameters. Antitumor effect of curcumin on ascites tumor cells produced by EAT cells evidenced with histopathological while antioxidant and anti-inflammatory biochemical parameters evidenced with biochemical parameters.

An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin Supplementation in Middle-Aged and Older Adults
Nutrients, October 2020
Curcumin has previously been shown to enhance mood in non-depressed older adults. In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both. Curcumin improved vigour (p = 0.044) compared to placebo and reduced SMCs compared to no curcumin treatment (p = 0.038). This exploratory analysis indicates that regular supplementation with either curcumin (or fish oil limited to APOE4 non-carriers) has the potential to improve some aspects of mental wellbeing in association with better quality of life.

Curcumin administration and the effects on psychological status and markers of inflammation and oxidative damage in patients with type 2 diabetes and coronary heart disease
Clinical Nutrition and Metabolism, October 2020
Curcumin intake significantly decreased Pittsburgh Sleep Quality Index (PSQI) (β -1.27; 95% CI, -2.27, -0.31; P=0.01) compared to the placebo group. Curcumin intake caused a significant reduction in malondialdehyde (MDA) (β -0.20 μmol/L; 95% CI, -0.36, -0.04; P=0.01), significant increase in total antioxidant capacity (TAC) (β 75.82 mmol/L; 95% CI, 3.400, 148.25; P=0.04) and glutathione (GSH) levels (β 63.48 μmol/L; 95% CI, 26.58, 100.37; P=0.001) when compared with the placebo. Additionally, curcumin intake upregulated peroxisome proliferator-activated receptor gamma (PPAR-γ) (P=0.01). Conclusion: Curcumin intake for 12 weeks in patients with T2DM and CHD had beneficial effects on PSQI, TAC, GSH, MDA values, and gene expression of PPAR-γ.

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin
Nutrients, October 2020
Curcumin, one of the major curcuminoids contained in the rhizome of Curcuma longa (turmeric), is a lipophilic polyphenol that has been used for centuries as an essential tool of traditional medicine in Asia. Curcumin has received considerable attention in the last years for its pharmacological activities. Due to the presence of conjugated double bonds in its chemical structure, this polyphenol serves as an effective electron donor to counteract the production of reactive oxygen species (ROS) in many redox reactions, acting as a potent antioxidant. In addition, it has other important biological functions, such as anti-inflammatory, antitumor, antimicrobial, and antiviral ones. Different studies highlighted that curcumin, like other dietary polyphenols, counteracts the effects of toxic damage in different tissues and, in addition, it is able to interfere with key cancer-associated signaling pathways by directly targeting proteins or regulating gene expression. According to its biological activities, curcumin has been proposed as a potential treatment for many diseases, among which are gastrointestinal, cardiovascular, and neurological disorders, diabetes, and several types of cancer . Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries in traditional Asian medicine, and nowadays it is widely used in food as dietary spice worldwide. It has received considerable attention for its pharmacological activities, which appear to act primarily through anti-inflammatory and antioxidant mechanisms. For this reason, it has been proposed as a tool for the management of many diseases, among which are gastrointestinal and neurological diseases, diabetes, and several types of cancer. The observed high concentrations of curcumin in the GI tract after oral administration can lead to two major effects: an altered gut microbiota and the modulation of intestinal functions. The scientific literatures were searched for in vivo, experimental and clinical studies, and human randomized controlled trials, reporting results on the interaction between curcumin and gut microbiota and vice versa.

Cardioprotective effect of curcumin against diabetic cardiomyopathy in type 1 diabetes mellitus
Naunyn-Schmiedeberg's Archives of Pharmacology, October 2020
Treatment with curcumin markedly reduced serum cardiac injury markers and lipid profile markers in diabetic animals. Additionally, curcumin treatment mitigated oxidative stress and fibrosis in diabetic rats as evident from the significant suppression in myocardial lipid peroxidation and tumor growth factor beta 1 (TGF-β1) level, with concomitant significant elevation in total antioxidant capacity (TAC) and improvement in histopathological architecture of heart tissue. Curcumin treatment protocol accomplished its cardioprotective effect by depressing cardiac CaMKII/NF-κB signaling accompanied by enhancement in PPAR-γ expression. Conclusively, these findings demonstrated the therapeutic potential of curcumin regimen in alleviating DCM in T1DM through modulation of CaMKII and PPAR-γ expression.

Curcumin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting Its Active Conformation
ACS Omega, October 2020
Flaviviruses including dengue virus and Zika virus encode a unique two-component NS2B-NS3 protease essential for maturation/infectivity, thus representing a key target for designing antiflavivirus drugs. Here, for the first time, by NMR and molecular docking, we reveal that curcumin allosterically inhibits the dengue protease by binding to a cavity with no overlap with the active site. Moreover, as curcumin has been used as a food additive for thousands of years in many counties, it can be directly utilized to fight the flaviviral infections and as a promising starting for further design of potent allosteric inhibitors.

Fight COVID-19 depression with immunity booster: Curcumin for psychoneuroimmunomodulation
Asian Journal of Psychiatry, September 2020
Curcumin is the bioactive component of turmeric, one of the key ingredients of prescribed ayurvedic interventions and spices used in meal preparation in South-East Asia. Known for immunoboosting aptitude, curcumin can alleviate the COVID-19 associated ill-effects including cytokine storm. Alleviating psychological stress by curcumin will also adjunct its immunoboosting potential. Curcumin can avert the anxiety and the stress-driven manifestation of depression through modulation of the monoaminergic troupe (dopamine, glutamate, serotonin, and noradrenaline) by curcumin. Curcumin, through Nuclear factor erythroid-2-related factor 2 (Nrf2), can prevent such stress and improve antioxidant Glutathione (GSH) production. Major depression disorders (MDD) associate with disturbances in the hypothalamus-pituitary-adrenal (HPA) axis. Curcumin can correct the HPA disturbances and avert elevated glucocorticoids, their receptor as well as inducers (cortisone and adrenocorticotropic hormone). Along with evident immunomodulator, turmeric component, especially curcumin exhibit antidepressant activity, and improve cognitive/mood function. The potential of curcumin containing nutraceutical in COVID-19 has been predicted both through PNI modulation and 'meaning response'. Moreover, curcumin can alleviate the overt inflammatory consequences, even those associated with COVID-19, and thus will improve physical well-being. Curcumin ameliorates inflammation and its regulators like STAT3 in a variety of disorders including COVID-19. Curcumin can improve the hematopoietic differentiation of immune cells; and thus can mitigate ill effects even through reinstating immune cells number. Moreover, curcumin improves neurogenesis and hippocampus functioning. Curcumin-mediated immunoboosting, antidepressant effect, and neurogenesis may also improve the mood function and ward off anxiety/stress in a covert manner. Nutraceuticals like curcumin can be a promising option as immunity boosters and antidepressants for PNI response. Traditionally used in medicinal practices, clinical safety of turmeric (and curcumin) is well assessed. Moreover, relative low case fatality rates (CFR) of COVID-19 in South-Asian countries like India are being recorded which can be governed by several factors, including diet and traditional medicine practice. Although the novel nature of the COVID-19 pandemic makes the efficacy of previously known drugs anonymous, ascertaining the true potential of curcumin through preclinical and clinical investigations will be of immense benefit. Immunoboosting as well as improvement of psychological well-being by curcumin; thus can be hypothesized to facilitate improvement in infected patients, health care workers as well as distantly affected individuals. Pyschoneuroimmunomodulation by curcumin, even as an adjuvant, can aid the fight against COVID-19.

Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells
Evidence-Based Complementary and Alternative Medicine, September 2020
Previous studies have confirmed that curcumin displays antitumor effects on a variety of cancers, including colorectal tumors. In addition, curcumin has been shown to prevent tumor resistance. Mehdi et al.  found that curcumin combined with 5-fluorouracil can improve the chemotherapeutic effects of 5FU on colorectal cancer resistant strains by reducing mismatch repair ability.  Curcumin can reverse the drug resistance of cancer cells. Curcumin was found to inhibit ERCC1 through its ability to modulate miR-409-3p. Curcumin can overcome L-OHP resistance in colorectal cancer cells through its effects on miR-409-3p mediated ERCC1 expression.

Curcumin (a constituent of turmeric): New treatment option against COVID‐19
Food Science & Nutrition, September 2020
We describe the possible therapeutic effects of curcumin and its molecular mechanism against coronavirus‐19. Curcumin, as an active constituent of Curcuma longa (turmeric), has been studied in several experimental and clinical trial studies. Curcumin has some useful clinical effects such as antiviral, antinociceptive, anti‐inflammatory, antipyretic, and antifatigue effects that could be effective to manage the symptoms of the infected patient with COVID‐19. Curcumin, as a potential agent, could be considered to treat COVID‐19. Curcumin, as an active constituent of rhizomes of C. longa (turmeric), is a hydrophobic polyphenol (Figure 1) (Akbar et al., 2018; Soleimani, Sahebkar, & Hosseinzadeh, 2018). Curcumin is used as a spice in foods and for different purposes such as cosmetic and pharmaceutical industries in world (Hosseini & Hosseinzadeh, 2018). Curcumin has several pharmacological effects such as antioxidant, anticancer, antibacterial, antiviral, and antidiabetic effects (Fan et al., 2015; Moghadamtousi et al., 2014; Zhu et al., 2017), as well as anti‐inflammatory activity (Cheng, Yang, Hu, Zhu, & Liu, 2018). As the potential role of curcumin to treat many inflammatory disorders, at the first step we will describe all effects of curcumin that may be useful to treat COVID‐19, and then, we explain the possible molecular mechanisms of it. We considered all articles of curcumin—human and animal studies—that could be effective to treat or rescue COVID‐19‐infected patients. PubMed and Web of Science were used as databases. As the importance of the subject, some selected papers were in the press. The keywords used for the search were as follows: coronavirus‐19, COVID‐19, SARS‐CoV‐2, curcumin, Curcuma longa, turmeric, curcumin and antiviral, curcumin and anti‐inflammatory, curcumin and antipyretic, curcumin and lung, curcumin and acute lung injury, curcumin and fatigue, curcumin and antioxidant, curcumin and ARDS, curcumin and bradykinin, curcumin and fibrosis, curcumin and Interleukin‐6 (IL‐6), curcumin and tumor necrosis factor‐alpha (TNF‐α), curcumin and NF‐κB, curcumin and Toll‐like receptors (TLRs), curcumin and antiapoptotic.  Scientific evidence suggests that curcumin could have a potential role to treat COVID‐19. Thus, the use of curcumin in the clinical trial, as a new treatment option, should be considered.

Curcumin supplementation and delayed onset muscle soreness (DOMS): effects, mechanisms, and practical considerations
Physical Activity and Nutrition, September
Curcumin, also called diferuloylmethane, is a well-known spice used in curry in India and other Asian countries. It is a natural polyphenol that has attracted attention for its anti-inflammatory, antioxidant, and anticancer activities. Studies have found that curcumin significantly reduces pain from burns as well as pathological pain caused by sciatic nerve injury, spinal cord injury, diabetic neuropathy, and alcoholic neuropathy. Researchers in the field of exercise physiology have investigated the effect of curcumin on post-exercise DOMS, with a few studies reporting that curcumin supplementation can effectively attenuate DOMS after high-intensity eccentric exercise.

Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
Medical Science Monitor, September 2020
Curcumin is a component of Curcuma longa with various biological activities. The present study aimed to investigate curcumin’s inhibitory effects on epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC) cells and possible mechanisms of action underlying these effects. Curcumin negatively regulated transcription factors promoting EMT in CRC cells by decreasing cdx2 promoter DNA methylation and consequently suppressing the CDX2/Wnt3a/ß-catenin signaling pathway.

Potential role of Curcumin against viral infections and pathogenesis of COVID-19
Department of Bioanalytical Sciences, September 2020
The review intended to provide link between natural product as treatment and COVID-19 disease. Therefore, this review summarizes the structure, pathogenesis as well as understanding the various role of curcumin as a treatment option for COVID-19 which includes: targeting viral entry to host cells, targeting viral replication, anti-viral, anti-inflammatory and anti-oxidant. Hence, curcumin can be a potential treatment option for COVID-19 patients and this review also suggest that more clinical research and development is needed in order to prepare a new drug for emerging SARS-CoV-2. Curcumin as an Antiviral Agent-Inhibition of Viral attachment/penetration. The antiviral activities of curcumin were observed from many evidences against vesicular stomatitis virus, parainfluenza virus type 3, vesicular stomatitis virus, flock house virus, herpes simplex virus, and respiratory syncytial virus. Curcumin can block the entry and budding of the virus by altering the structure of the surface protein in viruses. Recently, a molecular docking analysis through in silico computational study Jena et al. revealed that curcumin have dual binding affinity directly with the S protein and ACE-2 receptor binding domain of the SARS-CoV-2 virus. ACE-2 is the receptor that binds with SARS-CoV-2 spike glycoprotein which promote the fusion ofmembrane and viral infection occurs through endocytosis. Therefore, spike glycoprotein is a potential candidate for drug targeting to inhibit the entry of virus.Binding of curcumin to receptor-binding domain (RBD) site of viral S protein and also to the viral attachment sites of ACE-2 receptor, revealed that curcumin can act as potential inhibitory agent for the entry of SARS-CoV2 viral protein. This in silico docking studies showedthat curcumin may effectively prevent the SARS-CoV2 entry into the host cell.  Many in vivo and in vitro studies showed that curcumin can inhibit the production and release of pro-inflammatory response, such as IL-1, IL-6, IL-8, TNF-α. Curcumin also decreases expression of many other inflammatory mediators, including MCP1,MIPI1, growth regulated oncogene alpha (GROα), GROβ, IP10, stromal cell derived factor 1 (SDF1), matrix metalloproteinase-2 (MMP-2), IFN-γ, and MMP-9, which regulate the activity of immune cells and inflammatory responses and promote fibrosis in the lung after infection. Anti-inflammatory activity of curcumin involves various signalling pathways, from which nuclear factor kappa B (NF-kB)plays a vital role in managing numerous inflammatory responses through multiple mechanisms.

 Does Curcumin Have a Role in the Interaction between Gut Microbiota and Schistosoma mansoni in Mice?
Pathogens, September 2020
Several studies have described therapeutic effects of curcumin which may arise from its regulative effects on intestinal microbiota. Curcumin induced high variation in the Enterobacteriaceae family, characterized by a significant reduction in E. coli and asignificant  increase in Pseudomonas sp. in both naïve and S. mansoni-infected mice, compared to untreated mice, in a dose-dependent manner. Additionally, our study showed the effects of high curcumin doses on S. mansoni infection immunological and parasitological parameters. These data support curcumin’s ability to promote Pseudomonas sp. known to produce schistosomicidal toxins and offset the sequelae of murine schistosomiasis.

Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats
Biomedicine & Pharmacotherapy, September 2020
Curcumin showed a protective effect against cisplatin-induced nephrotoxicity. Combination of curcumin and melatonin showed an additive nephroprotective effect.  Nephroprotection is attributed to their anti-inflammatory and antioxidant actions.

Curcumin Suppresses Aldosterone-Induced CRP Generation
Evidence-Based Complementary and Alternative Medicine, September 2020
Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.

Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management
Indian Journal of Clinical Biochemistry, September 2020
Curcumin is one of the natural compounds that had been widely investigated for its antiviral effects. Curcumin, a natural polyphenolic compound extracted from roots of rhizome plant Curcuma longa (family Zingiberaceae), exhibits wide range of therapeutic properties including antioxidant, anti-microbial, anti-proliferative, anti-inflammatory, neuroprotective and cardioprotective properties. Curcumin, the yellow pigment of turmeric is extensively used in our Indian traditional herbal medicines to cure many diseases associated with infection and inflammation for many decades. It is reported that, curcumin exerts antiviral activities against broad spectrum of viruses including HIV, HSV-2, HPV viruses, Influenza virus, Zikavirus, Hepatitis virus and Adenovirus. In conclusion, we propose that curcumin could be used as a supportive therapy in the treatment of COVID19 disease in any clinical settings to circumvent the lethal effects of SARS-CoV-2.

Can concomitant use of zinc and curcumin with other immunity‐boosting nutraceuticals be the arsenal against COVID‐19?
The Pharmacological Potential of Plant Compounds in COVID-19, September 2020
We can expand our discussion by taking the example of two nutritional supplements—Curcuminoids and Zn—which have been classified under GRAS, by FDA, as nutraceutical and nutrient. Both molecules have a proven history of antiviral activity in both in vitro and in vivo trials, and thus could be leading in developing new prophylactic candidates against COVID‐19. Curcumin is a natural bioactive polyphenolic compound isolated from the dried powder of Curcuma longa rhizomes, commonly known as turmeric (Haldi in Hindi), and widely used worldwide for cooking. For example, it exerts an anti‐inflammatory action in arthritis and inflammatory bowel diseases, reduces lipid levels in cardiovascular diseases, and addresses oxidative stress in skin disorders (Pagano, Romano, Izzo, & Borrelli, 2018). Curcumin has an established track record as an antiviral agent against several viruses like Influenza Type A, Hepatitis A, Zika, HIV, etc. The mode of action of curcumin includes—inhibition of viral entry into cells, suppression of viral replication, stimulation of interferons (IFNs) and other cytokines, and inhibition of viral protein expression. In silico studies have also revealed that curcumin binds directly with the receptor‐binding domain of the viral spike protein (involved in host cell binding) and the cognate host cell receptor, angiotensin‐converting enzyme‐2 (serves as a medium of viral entry), of SARS‐CoV‐2 virus (Figure 1). Moreover, curcumin has been reported to inhibit the release and suppress numerous cytokines like IL‐1β, IL‐6, IL8, TNFα, MCP‐1, etc. When investigated in various viral infections set‐up, the mode of cytokine suppression by curcumin can be correlated with clinical improvement in conditions associated with cytokine storm (Sordillo & Helson, 2015). Following the suggested interaction with these key components of the viral lifecycle and immune system, it is apparent that curcumin could prevent the COVID‐19 infection. Moreover, in recent years, blood coagulation properties of curcumin (by inhibiting platelet aggregation, cyclooxygenase pathway, and blocking of calcium signaling) have been utilized in designing various materials and devices (Keihanian, Saeidinia, Bagheri, Johnston, & Sahebkar, 2018). As the SARS‐CoV‐2 coronavirus infection can be associated with a disseminated intravascular coagulopathy, hence curcumin can be an effective agent against this pathological condition.

The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia
Frontiers in Cell and Developmental Biology, September 2020
Coronavirus infection, including SARS-CoV, MERS-CoV, and SARS-CoV2, causes daunting diseases that can be fatal because of lung failure and systemic cytokine storm. No drugs are available to suppress overly immune response-mediated lung injury effectively. In light of the low toxicity and its antioxidant, anti-inflammatory, and antiviral activity, it is plausible to speculate that curcumin could be used as a therapeutic drug for viral pneumonia and ALI/ARDS. Therefore, in this review, we summarize the mounting evidence obtained from preclinical studies using animal models of lethal pneumonia where curcumin exerts protective effects by regulating the expression of both pro- and anti-inflammatory factors such as IL-6, IL-8, IL-10, and COX-2, promoting the apoptosis of PMN cells, and scavenging the reactive oxygen species (ROS), which exacerbates the inflammatory response. These studies provide a rationale that curcumin can be used as a therapeutic agent against pneumonia and ALI/ARDS in humans resulting from coronaviral infection.

Catechin and Curcumin interact with corona (2019-nCoV/SARS-CoV2) viral S protein and ACE2 of human cell membrane
Pharmacodynamics,  September 2020
The recent outbreak of the coronavirus (2019n-CoV) is an unprecedented threat for human health throughout the globe.  Here, through computational approaches we have reported two polyphenols, Catechin and Curcumin which have dual binding affinity i.e both the molecule binds to viral S-protein and as well as ACE2. Molecular simulation study demonstrates that curcumin directly binds with RBD site of S-protein during 40-100ns. In conclusion, this computational study for the first time predicts the possibility of above two polyphenols, for therapeutic/preventive intervention.

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: curcuminoids against novel SARS-CoV-2
Royal Society of Chemistry, August 2020
We focused on the natural plant Curcuma longa, commonly known as turmeric, a perennial herbaceous rhizomatous plant belonging to the ginger family Zingiberaceae, which is widely used in India.Curcuma longa chemical constitutes are widely used for treating various ailments and possess a wide variety of therapeutic properties including antiviral,analgesic,antimicrobial,antiproliferative,and anti-inflammatory activity. Among the various chemical compounds, curcumin has gained importance among researchers because its compounds have been exhibited activity against viruses such as the human immunodeficiency virus (HIV), dengue virus, herpes simplex virus (HSV), hepatitis virus, influenza A virus (IAV), and Ebola virus.SARS-CoV-2 has resulted in a devastating pandemic with global concern; however, present therapies in virology fail to prevent its effects. Currently, there is exigency in identifying novel leads with anti-viral properties to impede viral pathogenesis in the host system. Thus, two important curcuminoids of turmeric, i.e., its curcumin keto and enol forms, were demonstrated to be complementary to bind with the S-glycoprotein and envelope protein of SARS-CoV-2. However, the keto form of curcumin is more favourable for both these drug targets considering its docking score, binding energy and molecular dynamics simulation. Thus, this study indicates that surface proteins are key drug target proteins of SARS-CoV-2, and probably curcumin blocks essential biologically active drug target residues, thereby attenuating the viral infection. Hence, this computational biology approach identifies curcumin as a drug candidate for further investigation in treating SARS-CoV-2.

Antiviral and virucidal effects of curcumin
Journal of General Virology, August 2020
Emerging coronaviruses represent serious threats to human and animal health worldwide, and no approved therapeutics are currently available. Here, we used Transmissible gastroenteritis virus (TGEV) as the alpha-coronavirus model, and investigated the antiviral properties of curcumin against TGEV. Our results demonstrated that curcumin strongly inhibited TGEV proliferation and viral protein expression in a dose-dependent manner. We also observed that curcumin exhibited direct virucidal abilities in a dose-, temperature- and time-dependent manner. Furthermore, time-of-addition assays showed that curcumin mainly acted in the early phase of TGEV replication. Notably, in an adsorption assay, curcumin at 40 µM resulted in a reduction in viral titres of 3.55 log TCID50 ml–1, indicating that curcumin possesses excellent inhibitory effects on the adsorption of TGEV. Collectively, we demonstrate for the first time that curcumin has virucidal activity and virtual inhibition against TGEV, suggesting that curcumin might be a candidate drug for effective control of TGEV infection.

Turmeric could have antiviral properties
Microbiology Society, August 2020
Curcumin, a natural compound found in the spice turmeric, could help eliminate certain viruses, research has found. A study published in the Journal of General Virology showed that curcumin can prevent Transmissible gastroenteritis virus (TGEV) – an alpha-group coronavirus that infects pigs – from infecting cells. At higher doses, the compound was also found to kill virus particles. The research suggests that curcumin affects TGEV in a number of ways: by directly killing the virus before it is able to infect the cell, by integrating with the viral envelope to ‘inactivate’ the virus, and by altering the metabolism of cells to prevent viral entry. “Curcumin has a significant inhibitory effect on TGEV adsorption step and a certain direct inactivation effect, suggesting that curcumin has great potential in the prevention of TGEV infection,” said Dr Lilan Xie, lead author of the study and researcher at the Wuhan Institute of Bioengineering. Curcumin has been shown to inhibit the replication of some types of virus, including dengue virus, hepatitis B and Zika virus. The compound has also been found to have a number of significant biological effects, including antitumor, anti-inflammatory and antibacterial activities. Curcumin was chosen for this research due to having low side effects according to Dr Xie.

Turmeric may have antiviral properties
labonline, August 2020
To determine the potential antiviral properties of curcumin, scientists from the Wuhan Institute of Bioengineering treated experimental cells with various concentrations of the compound, before attempting to infect them with TGEV. They found that higher concentrations of curcumin reduced the number of virus particles in the cell culture.

Curcumin enhances anti‑cancer efficacy on pancreatic cancer cells
Oncology Reports, August 2020
Curcumin is a natural compound extracted from turmeric (Curcuma longa), which has been reported to be a promising anti‑cancer drug in various human cancers. Curcumin exhibited marked suppressive ability on metastasis of PC cells by wound healing and matrigel‑transwell assay. Mechanistically, upregulation of TIMP1/TIMP2 with concomitant downregulation of MMP2/MMP9/N‑cadherin proteins may be involved in this process. In conclusion, curcumin showed synergistic anti‑cancer effects with either gemcitabine or docetaxel on PC cells.

Accelerated Muscle Recovery After In Vivo Curcumin Supplementation
Graduate Institute of Metabolism and Obesity Sciences, August 2020
For the contusion-induced muscle injury, curcumin could affect the specific proteins of inflammation, neutrophils, and differentiation of satellite cells, including Ikk-α/ß, MPO, and myogenin. In conclusion, curcumin potentially accelerates muscle recovery; therefore, it may be a potential candidate for further research as an effective treatment to enhance muscle repair.

Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin
Drug Design, Development and Therapy, August 2020
The administration of curcumin before and after irradiation prevented radiotherapy-induced oxidative damage by significantly elevating the activities of antioxidant enzymes. From the findings of the present study, curcumin showed potential for protection against radiotherapy induced oxidative injury to the skin. However, future studies are required to evaluate its clinical efficacy.

The Spice That Protects Your Brain
TheEpochTimes, August 2020
Previous research on curcumin indicates that it is capable of acting as an antioxidant in three distinct ways by protecting against 1) singlet oxygen, 2) hydroxyl radicals, and 3) superoxide radical damage. Also, curcumin appears to raise endogenous glutathione production in the brain, a major antioxidant defense system. Supplementation with curcumin significantly reduced the toxic effect of fluoride to near normal level by augmenting the antioxidant defense through its scavenging property and provides evidence of having a therapeutic role against oxidative stress mediated neurodegeneration.” This is far from the first study to demonstrate curcumin’s remarkable brain-saving properties. From the perspective of the primary research alone, there are more than 200 peer-reviewed published studies indicating that curcumin is a neuroprotective agent. On GreenMedInfo’s turmeric database there are 115 articles proving turmeric protects the brain. There are also two featured studies on turmeric’s ability to protect and restore the brain: How Turmeric Can Save the Aging Brain From Dementia and Premature Death, and Turmeric Produces ‘Remarkable’ Recovery in Alzheimer’s Patients. Considering the many chemical insults we face on a daily basis in the post-industrial world, turmeric may very well be the world’s most important herb, with more than 800 evidence-based health applications.

Effects of curcumin, D-pinitol alone or in combination in cytotoxicity induced by arsenic
Food and Chemical Toxicology, August 2020
Curcumin  decreases cell viability of PC12 cells unlike D-pinitol. Arsenic induced cell death via both mitochondria-mediated intrinsic apoptosis and autophagy. Curcumin and D-pinitol alone or in combination efficiently protects PC12 cells from arsenic-induced cytotoxicity.  The combined cytoprotection of curcumin and D-pinitol against arsenic-toxicity was higher than their individual protection.

Magical benefits of herbs
Northampton Chronicle, August 2020
Curcumin is undergoing many studies to investigate its anti-inflammatory properties. Already shown to be able to slow down inflammation, there are clinical trials being performed comparing this compound with anti-inflammatory drugs, like Ibuprofen. Curcumin has also been linked to helping pre-menstrual tension, acne, arthritis, depression. Clinical studies are also under way to investigate its function with Alzheimer’s Disease and some cancers.

Potential Effects of Curcumin in the Treatment of COVID-19 Infection
Phytotherapy Research, July 2020
Coronavirus disease (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.

Antiviral benefits of curcumin
nutritionaloutlook, July 2020
A new review explores the potential effects of curcumin on COVID-19 infection. Based on existing data from in silico and animal studies on curcumin and viral infection, the review serves as a groundwork for future study of curcumin as a possible treatment. The review cites studies that point to curcumin’s ability to potentially inhibit the entry of virus to the cell, inhibit encapsulation of the virus and viral protease, as well as modulate various cellular signaling pathways. The review also cites studies in which curcumin was effective in pulmonary inflammation, fibrosis, and edema, as well as the recuperative actions of curcumin on cardiac and kidney damage caused by viral infections.

Curcumin - Properties, Applications and Modification of Structure
eurekaselect, July 2020
In recent years, the interest in biologically active compounds of natural origin has increased significantly. Researchers' research focuses on increasing the activity of curcumin by forming complexes with metals such as vanadium, iron, copper or gallium. Introduction of metal compounds to curcumin increases the scope of application in pharmacology. The main direction of research development is the treatment of tumors, among others stomach cancer or leukemia. Curcuminoids are the main components of turmeric (Curcuma longa L.), a plant from India and South-East Asia. Due to its intense yellow-orange color and pleasant aroma, the powdered rootstalk is widely used in the food industry, as natural dye and spice. The chemical compound responsible for the characteristic color of rhizomes of curcuma is 1,6-heptadien-3,5-dione-1,7-bis(4-hydroxy-3-methoxyphenyl) - (1E, 6E) called curcumin. This work aims to characterize curcumin in terms of its structure, therapeutic properties and also as a substrate for the synthesis of valuable derivatives like tetrahydrocurcumin. Knowledge about this relationship based on literature analysis will enable a better understanding of the factors responsible for its biological activity.

Turmeric: The Spice for Life
ttownmedia, July 2020
For centuries it has been known that turmeric exhibits anti-inflammatory activity, but extensive research performed within the past two decades has shown that this activity of turmeric is due to curcumin. The process of inflammation has been shown to play a role in most chronic illnesses, including neurodegenerative, cardiovascular and autoimmune. In this study published in the Jan. 2009 issue of the " International Journal of Biochemistry & Cell Biology" researchers provided evidence for the potential role of curcumin in the prevention and treatment of various proinflammatory chronic diseases. Because curcumin can help keep blood sugar levels steady, it could be effective as a way of preventing or treating type 2 diabetes. One study, as reported in an article on turmeric in WEB MD, followed 240 adults with prediabetes and found that taking a curcumin supplement over 9 months lowered their odds of developing diabetes. Additionally, curcumin has shown promise for its ability to ease joint pain, stiffness, abdominal pain, headaches and migraines. There is evidence to suggest the curcumin may help in weight loss. Studies find that curcumin may regulate lipid metabolism, which plays a central role in the development of obesity and its complications. ` Research published in the journal "Pharmaceutical Research" Jan 2017 discusses the evidence of curcumin's effectiveness on pulmonary diseases such as asthma, COPD, pulmonary fibrosis and lung cancer. According to Dr. Goel, Ph.D., director of Cancer Prevention at Baylor University Medical Center and curcumin researcher: "Curcumin demonstrates superior antioxidant and anti-inflammatory effects and provides liver- and heart-protective benefits as well. It is a potent antibacterial, antifungal, antiviral, anti-allergenic and has antitumor and anti-cancer properties." A Randomized Controlled Trial reported in the Aug. 2009 issue of "The Journal of Alternative and Complementary Medicine" conclude that curcumin was as safe and effective for treating knee osteoarthritis as ibuprofen. A 2016 Meta-Analysis of over 28 studies concluded that scientific evidence supported the efficacy of turmeric extract (about 1000 mg/day of curcumin) in the treatment of arthritis.

Curcumin-enhanced antitumor effects
Food & Function, July 2020
Curcumin, the main active ingredient of turmeric, is widely used as a kind of food additive and also displays a range of pharmacological activities, such as anti-inflammation, anti-tumor, liver and kidney protection, and so forth.  It was found that curcumin protected against liver cancer progression through reducing the level of alpha fetoprotein in liver tissues, increasing the number of immune cells, like NK cells, inhibiting EMT via the regulation of IL-6/JAK/STAT3 and IL-1β/NF-κB pathways, suppressing anaerobic glycolysis through the inhibition of LDH and HIF-1α, and decreasing the lipid synthesis via the downregulation of FASN, and upregulated the serum HDL-C and mRNA levels of apoA1 in the sorafenib-treated mice. Furthermore, curcumin regulation of the disorder of glycolipid metabolism and EMT was also based on the PI3K/AKT pathway. A docking study was performed and proved the strong affinity between curcumin and the proteins of STAT3, FASN, and AKT. All in all, this experiment provided evidence for the addition of curcumin in the diet to enhance the antitumor efficacy of sorafenib through activating immune function, downregulating EMT, and reversing disorders of the metabolism.

Support Your Immune System
marieclaire, July 2020
Turmeric rates as a high immunity-boosting food due to the levels of curcumin that are found in it. Curcumin can enhance the antibody response by activating the T cells, B cells, neutrophils (white blood cells that heal damaged tissues and resolve infections) and Natural Killer cells, all of which help your body to fight off infection. Curcumin is also a fantastic anti-inflammatory, which helps your immune system by reducing the amount of inflammation within your body. The more inflammation you have, the less able your body is able to fight off any potential microbes.

Curcumin exerts protective effect on PC12 cells
europeanreview, July 2020
Our study indicates that curcumin exerts protective effect against lidocaine-induced cytotoxicity on PC12 cells by suppressing the activity of NLRP3 inflammasome, which provides new ideas on screening natural product for neurological damage therapy.

Curcumin protects BV2
Molecular Biology Reports, July 2020
Curcumin was demonstrated to be an active ingredient with anti-inflammatory effects. This research was to investigate the effects of curcumin. We found that curcumin promoted cell viability and suppressed cell apoptosis. Meanwhile, curcumin decreased the level of cleaved caspase-3 and the release of TNF-α, IL-1β, IL-6, but increased IL-10 release in LPS-treated BV2 cells. Furthermore, curcumin suppressed p-p65 expression via regulating miR-362-3p/TLR4 axis. We discovered that curcumin exhibited protective effects against LPS-triggered cell injury via modulating miR-362-3p/TLR4 axis through NF-κB pathway.

Improving Lung Function
ndtv, July 2020
Curcumin in turmeric has antioxidant and anti-inflammatory effects which can be beneficial for supporting lung function.

Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells
Oxidative Medicine and Cellular Longevity, July 2020
Curcumin, a natural polyphenol antioxidant extracted from the root of turmeric (Curcuma longa), can induce apoptosis and DNA demethylation in several types of cancer cells. We observed that curcumin inhibited the proliferation, colony formation, and migration of hGCCs in a dose- and time-dependent fashion. A high concentration of curcumin elevated ROS levels and triggered mitochondrial damage, DNA damage, and apoptosis of hGCCs. Further, curcumin-induced DNA demethylation of hGCCs was mediated by the damaged DNA repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis. We propose that the anticancer effect of curcumin could largely be attributed to its prooxidative effect at high concentrations and ROS elevation in cancer cells. Moreover, we present a novel mechanism by which curcumin induces DNA demethylation of hGCCs, suggesting the need to further investigate the demethylation mechanisms of other DNA hypomethylating drugs.

Type 2 diabetes: A spice proven to help lower blood sugar and help with treatment
express.co.uk
In a study with the US National Library of Medicine National Institutes of Health, curcumin and how it affects diabetes was investigated. The study noted: “The active component of turmeric, curcumin, has caught attention as a potential treatment for diabetes and its complications primarily because it is a relatively safe and inexpensive drug that reduces glycemia and hyperlipidaemia in rodent models of diabetes. “The spice turmeric, which is derived from the root of the plant Curcuma longa, has been described as a treatment for diabetes in Ayurvedic and traditional Chinese medicine for thousands of years. “Recent research has provided the scientific basis for “traditional” curcumin and confirmed the important role of curcumin in the prevention and treatment of diabetes and its associated disorders. Curcumin could favourably affect most of the leading aspects of diabetes, including insulin resistance, hyperglycaemia, hyperlipidaemia, and islet apoptosis and necrosis.”

Curcumin Potentiates Laryngeal Squamous Carcinoma Cancer
Journal of Receptors and Signal Transduction, July 2020
Curcumin has shown efficacy in promoting radiosensitivity combined with radiotherapy. Curcumin significantly enhanced irradiation-induced DNA damage and apoptosis, while weakening clone-forming abilities of LSCC cell line Hep2 and Hep2-max. Compared to Hep2 cells, Hep2-max cells are more sensitive to curcumin post-irradiation. Curcumin enhances LSCC radiosensitivity via NF-ΚB inhibition by suppressing IKKγ expression.

Curcumin For Better Memory?
drweil.com July 2020
Curcumin is a compound found in the spice turmeric. Both give the yellow color to curry powder and American mustard. The possibility that curcumin could prevent – or treat – memory problems, including Alzheimer’s disease, is suggested in part by population studies showing that elderly villagers in India have the world’s lowest rate of Alzheimer’s, perhaps because their traditional diet provides turmeric with almost every meal. Curcumin is a powerful antioxidant and also has anti-inflammatory properties that might protect against Alzheimer’s, which begins as an inflammatory process in the brain. The latest findings on curcumin’s effects come from a small, double-blind, placebo-controlled UCLA study showing that curcumin supplements improved memory and mood in 40 people between the ages of 51 and 84 with mild, age-related memory loss. The participants were randomly assigned to receive either 90 milligrams of an easily absorbed form of curcumin twice daily for 18 months or a placebo. The form of curcumin used in this study is key; many forms are not well absorbed from the GI tract, so that little gets into the bloodstream and even less gets past the blood-brain barrier. All the UCLA study participants received standardized cognitive assessments when the study began and every six months afterwards. In addition, 30 of them had PET scans at the investigation’s beginning and end to determine their levels of amyloid-beta and tau, the abnormal proteins that make up the plaques and tangles that progressively obstruct cerebral function in Alzheimer’s disease. At the end of the study, the team found that memory improved by 28 percent in the participants who took curcumin. No such changes occurred in those who received the placebo. Those who took curcumin also showed mild improvements in mood, and their PET scans revealed significantly less amyloid and tau proteins in brain regions that control memory and emotional functions. In news reports, the study’s first author, Gary Small, M.D., director of geriatric psychiatry at UCLA’s Longevity Center, said it isn’t known exactly how curcumin exerts theSE effects, but they may be due to its ability to reduce brain inflammation, A factor in both Alzheimer’s disease and major depression.

Managing autoimmune disorders
Times Of India, July 2020
Curcumin is the main active ingredient in turmeric. It has powerful anti-inflammatory effects and is a very strong antioxidant. It helps the body fight foreign invaders and also has a role in repairing damage. Circumin helps fight many autoimmune diseases. It not just neutralizes free radicals on its own but also stimulates the body's own antioxidant enzymes. Curcumin leads to various changes at the molecular level that may help prevent and even heal a cancer.

Struggle with Schizophrenia? Curcumin May Make the Difference
Natural Path Newsletter, July 2020
To see if curcumin could widen the treatment to include the negative symptoms of schizophrenia, researchers added either a placebo or 3g of curcumin a day to the antipsychotic drugs of 38 people with chronic schizophrenia in a double-blind study. At the end of the six month study, there was a significantly better response in the curcumin group on the Positive and Negative Symptoms Scale (PANSS) and on the negative symptoms subscale. The researchers call these results “promising” because they suggest a safe, effective, natural way of addressing the previously resistant negative symptoms of schizophrenia.

Antibacterial Mechanism of Curcumin: A Review
Chemistry & Biodiversity, July 2020
Curcumin is a plant‐derived polyphenolic active substance with broad‐spectrum antibacterial properties. Curcumin blocks bacterial growth owing to its structural characteristics and the generation of anti‐oxidation products. Curcumin can inhibit bacterial virulence factors, inhibit bacterial biofilm formation and prevent bacterial adhesion to host receptors through the bacterial quorum sensing regulation system. Moreover, it can exert a synergistic antibacterial effect with other antibacterial substances. In this review, we summarize the research progress on the antibacterial mechanism of curcumin based on five targeting structures and two modes of action. Our discussion provides a theoretical basis and technical foundation for the development and application of natural antibacterial agents.

Benefits of using Turmeric
bolnews, July 2020
Turmeric dramatically increases the antioxidant capacity of the body. The main reason antioxidants are so beneficial is that they protect your body from free radicals. Curcumin is a potent antioxidant that can neutralize free radicals due to its chemical structure. Turmeric boosts levels of the brain hormone BDNF, which increases the growth of new neurons and fights various degenerative processes in your brain. Turmeric leads to several changes on the molecular level that may help prevent and perhaps even treat cancer.

Curcumin ameliorates CKD-induced mitochondrial dysfunction and oxidative stress
The Journal of Nutritional Biochemistry, July 2020
Curcumin could exert beneficial effects, including weight maintenance and improved muscle function, increased mitochondrial biogenesis, alleviated mitochondrial dysfunction by increasing adenosine triphosphate levels, activities of mitochondrial electron transport chain complexes and basal mitochondrial respiration and suppressing mitochondrial membrane potential. In addition, curcumin modulated redox homeostasis by increasing antioxidant activity and suppressed mitochondrial oxidative stress. Moreover, the protective effects of curcumin had been found to be mediated via inhibiting GSK-3β activity in vitro and in vivo. Importantly, GSK-3β KO contributed to improved mitochondrial function, attenuated mitochondrial oxidative damage and augmented mitochondrial biogenesis in muscle of CKD. Overall, this study suggested that curcumin alleviated CKD-induced mitochondrial oxidative damage and mitochondrial dysfunction via inhibiting GSK-3β activity in skeletal muscle.

How to live longer
express.co.uk, July 2020
In a study with the US National Library of Medicine National Institutes of Health, turmeric extract and its active compound, curcumin and how it can help with liver damage was investigated. The study noted: “Curcumin, a major active component of turmeric, has previously been reported to alleviate liver damage. “We hypothesized that turmeric extract and curcumin protect the liver by reducing oxidative stress, inhibiting lipid peroxidation.” The study found that curcumin can protect against liver damage and that potential liver and gallbladder benefits of curcumin include increasing production of the digestive fluid bile while also protecting liver cells from damage from bile-associated chemicals.

Studies on Curcumin with COVID-19 Proteins
Biochemistry, June 2020
Curcumin, a natural bioactive molecule has been shown to have a therapeutic potential for various diseases, but no role of it in COVID-19 has been explored. In this work, we show the binding potential of curcumin targeted to a host of SARS-CoV-2 proteins. Our results indicate that curcumin has potential antiviral protein binding affinity towards SARS-CoV-2 proteins which is comparable with other repurposed drugs that are considered for clinical trials.

Effects of curcumin on neurological diseases
Pharmacological Reports, June 2020
Curcumin, the major active component of turmeric, belongs to the curcuminoid family that was originally isolated from the plant Curcuma longa. Several studies suggest that curcumin may have a beneficial impact on the brain pathology and aging. These effects are due to curcumin’s antioxidant, free-radical scavenging, and anti-inflammatory activity. In light of this, our current review aims to discuss the role of astrocytes as essential players in neurodegenerative diseases and suggest that curcumin is capable of direct inhibition of astrocyte activity with a particular focus on its effects in Alexander disease, Alzheimer's disease, ischemia stroke, spinal cord injury, Multiple sclerosis, and Parkinson’s disease.

Effects of curcumin on breast cancer cell proliferation
International Journal of Oncology, June 2020
Only curcumin and B(Cur)2 inhibited cell migration. Furthermore, cell exposure to curcumin resulted in an increase in the relative expression of the two key proapoptotic proteins, cytochrome c and cleaved caspase‑3, as well as the antiapoptotic protein haem oxygenase‑1. In addition, curcumin increased the expression levels of the voltage‑gated potassium channels Kv2.1 and Kv3.2. Similarly, the expression levels of the chloride channel bestrophin‑1 and the calcium channel coding gene calcium voltage‑gated channel auxiliary subunit γ4 were increased following exposure to curcumin.  Fe(Cur)3 and B(Cur)2 may display similar anticancer properties as curcumin.

Curcumin's potential to fight COVID-19
Manorama Online, June 2020
Curcumin is an integral part of two among the three research projects undertaken by MG varsity VC and his team of scientists

Consequences of long-term low-dose curcumin exposure in lung cancer cells
Molecules, June 2020
Curcumin has been investigated extensively for cancer prevention, but it has been proposed that long-term treatments may promote clonal evolution and gain of cellular resistance, potentially rendering cancer cells less sensitive to future therapeutic interventions. Curcumin (0.25–0.5 µM) was able to inhibit the invasion of both native and chemo-resistant NSCLC cells in the organotypic co-culture model.

Local doctor says food, spices in your home could boost your immunity
Boston 25 News, June 2020
 A recent New York Times article said that most Americans don’t have the diet or overall health to fight COVID-19. A Weymouth doctor said a strong immune system is needed to fight the virus. Dr. Pat Hopkins, a rheumatologist and director of the Boston Functional Medicine Group, looks at the root cause of diseases. “I always like to say the best offense is a good defense so you’re building up your immune system,” Hopkins said. “If you get the virus your immune system should roll over and say no problem.” Hopkins said the best way to flatten the curve and protect yourself from coronavirus.  Here’s a list of Hopkins’ top supplements to help boost your immunity:  Curcumin, 500 to 1000 MG twice a day.

Bioactive immunity booster
PinkVilla.com June 2020
The key substance which makes turmeric so useful and powerful is Curcumin. Due to its antioxidant, anti-inflammatory, and antimicrobial properties, it aids to combat inflammation, which is the origin of many chronic diseases in the body and also lessens immunity. It has also proven to be a super ingredient to strengthen joints, have a stronger heart, sharper brain, and a healthy liver. Curcumin is also effective for healthy and glowing skin and its consumption keeps viruses and infections at bay.

Curcumin ameliorates CKD-induced mitochondrial dysfunction and oxidative stress through inhibiting GSK-3β activity
The Journal of Nutritional Biochemistry, June 2020
Curcumin has been reported to attenuate muscle atrophy.  Moreover, the protective effects of curcumin had been found to be mediated via inhibiting GSK-3β activity in vitro and in vivo. Importantly, GSK-3β KO contributed to improved mitochondrial function, attenuated mitochondrial oxidative damage, and augmented mitochondrial biogenesis in muscle of CKD. Overall, this study suggested that curcumin alleviated CKD - induced mitochondrial oxidative damage and mitochondrial dysfunction via inhibiting GSK-3β activity in skeletal muscle.

Antiviral Foods To Boost Your Immune System
Refinery29.com June 2020
Curcumin, a compound found in turmeric, has powerful anti-inflammatory properties. Davis says that even low doses of it enhances antibody responses, an indicator that your body is fighting off illnesses. You can cook with turmeric, a spice, but you can find curcumin supplements at any health food store too.

Lower concentrations of curcumin inhibit Her2-Akt pathway components in human breast cancer cells
Nutrition Research, June 2020
Curcumin has emerged as a potential co-treatment for this and other cancers, but prior studies have focused on non-attainable concentrations. These studies demonstrate that a physiological attainable level of curcumin (1.5 μM) can reduce some components of the critical Her2-Akt pathway; that even more complete inhibition can be achieved by combination with other dietary botanicals; and that curcumin and other botanicals can potentiate the action of the human epidermal growth factor receptor 2 cancer metastatic drug lapatinib, in turn suggesting the potential anti-cancer clinical use of these botanicals.

Curcumin for the Management of Periodontal Diseases: A Review
Current Pharmaceutical Design, June 2020
Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receiving attention for the management of periodontitis owing to their general safety and efficacy. Curcumin, a bioactive polyphenol extracted from Curcuma longa, has been shown to possess antioxidant, antimicrobial, anti-inflammatory and analgesic properties. Several studies have assessed the efficacy of curcumin against periodontal diseases. These studies have shown equivalent or even higher efficacy of curcumin compared to the commonly used medications for the management of periodontitis such as chlorhexidine. Herein, we review the experimental and clinical findings on the anti-periodontitis effects of curcumin and the pharmacological mechanisms underlying these effects.

The Best Anti-Aging Supplements For Longevity
Longevity Live, June 2020
Curcumin is responsible for the vibrant yellow color of turmeric. With its anti-inflammatory effects, curcumin could be exactly what your aged skin needs. In fact, one study associated turmeric intake with a reduced risk of age-related mental decline in humans.  A separate study published in the Phytotherapy Research journal found that the topical application and oral ingestion of curcumin supplements helped to alleviate the appearance of not only aging, but that of skin damage caused by UV rays.

Curcumin alleviates OGD/R‐induced PC12 cell damage via repressing CCL3 to suppress inflammation and apoptosis
Journal of Pharmacy and Pharmacology, June 2020
Curcumin presents some therapeutic effects including anti‐cancer and anti‐inflammation. Herein, we centered on the functional role of curcumin in cerebral ischaemia injury and its potential molecular mechanisms. Our study manifested that curcumin might be a meritorious drug for the treatment of cerebral ischaemia by acting on CCL3.

Best supplements for diabetes - the 'amazing' capsules to protect against high blood sugar
Express, June 2020
Curcumin improves insulin resistance in some diabetes patients, according to nutritionist Dr Sarah Brewer. The spice could also protect against some of the severe complications of high blood sugar. Its anti-inflammatory properties mean that patients aren't as likely to develop neuropathy, or damage to their blood vessels. People with prediabetes could also benefit from taking turmeric supplements, added the nutritionist. "Curcumin supplements have also been shown to improve insulin resistance by activating insulin receptors. "In people with poor glucose tolerance [prediabetes], turmeric can delay the onset of type 2 diabetes. "These are amazing results and it’s no wonder that turmeric is an increasingly popular natural treatment for type 2 diabetes."

Curcumin inhibited mitochondrial apoptosis induced by PCV2 virus
Research Square, June 2020
Curcumin has significant antiviral effect. And the PCV2-induced Mitochondrial apoptosis was mainly remitted by Curcumin.

Putting health first
Daily Pioneer, June 2020
Known for its anti-oxidant and anti-inflammatory properties, Curcumin, the compound present in turmeric is a very potent agent and aids in healing of wounds and infections. This bright yellow, bitter spice has also been used for years as an anti-inflammatory in treating both osteoarthritis and rheumatoid arthritis. Research shows that high concentrations of curcumin, which gives turmeric its distinctive color, can help decrease exercise-induced muscle damage. Curcumin has promise as an immune booster (based on findings from animal studies) and an antiviral.

 Curcumin (Diferuloylmethane) Induces Apoptosis in Mantle Cell Lymphoma
Biochemical Pharmacology, June 2020
We used curcumin, a pharmacologically safe agent, to target NF-kappaB in a variety of MCL cell lines. On treatment of cells with curcumin, however, downregulated constitutive active NF-kappaB and inhibited the consitutively active IkappaBalpha kinase (IKK), and phosphorylation of IkappaBalpha and p65. Curcumin also inhibited constitutive activation of Akt, needed for IKK activation. Consequently, the expression of all NF-kappaB-regulated gene products, were downregulated by the polyphenol leading to the suppression of proliferation. Overall, our results indicate that curcumin inhibits the constitutive NF-kappaB and IKK leading to suppression of expression of NF-kappaB-regulated gene products that results in the suppression of proliferation, cell cycle arrest, and induction of apoptosis in MCL.

Exercise and Curcumin in Combination Improves Cognitive Function and Attenuates ER Stress in Diabetic Rats
Nutrients, June 2020
Curcumin is a natural compound with known antioxidant and anti-inflammatory properties. Exercise plus curcumin improved escape latency and memory retention compared to OLETF controls. Furthermore, OLETF rats exercised and fed curcumin had lower IL6, TNFα, and IL10 levels (indicators of inflammatory response) and lower levels of ER stress markers (BiP and CHOP) in the intestine than OLETF controls. These observations suggest exercise plus curcumin may offer a means of treating diabetes-related cognitive dysfunction.

Curcumin Administration Mitigates Oxidative Damage and Restores Alteration of Enzymes Associated with Cognitive Function in Rats’ Brain
Neurotoxicity Research, June 2020
Curcumin also improved redox balance and showed protection against cyclophosphamide-induced oxidative damage to rats’ brain via an increase in protein and non-protein thiols and nitric oxide levels as well as a significant reduction in malondialdehyde levels. Curcumin also prevented neuronal degeneration in different brain regions and reduced caspase-3 expression. Hence this study suggests that pre and post-treatment with curcumin improved neurobehavior, modulates some biomarkers associated with cognitive function and exhibit neuroprotection against cyclophosphamide-induced neurotoxicity in rats.

Curcumin Confer Radiosensitizing Effect in Breast Cancer
American Journal of Biochemistry and Molecular Biology, May 2020
Curcumin reduced the proliferation rate of cells. Correspondingly, wound healing assay resulted in control of the cell-cell interaction and cell migration at two different time points. Conclusion: In conclusion, curcumin along with a lower dose (8 Gy) of radiation acted as the best combinatorial drug treatment for breast cancer cell lines. Our findings put up a rationale for further clinical/preclinical analysis of combination treatments with a lower dose and fewer side effects in breast cancer.

COVID-19: Herbs That Strengthen Your Immune System
outlookindia, May 2020
Turmeric contains a bioactive compound known as curcumin, which acts as an anti-inflammatory agent.

Curcumin effect on cancer cells
Phytotherapy Research, May 2020
Curcumin is a natural phenolic compound which shows potent anticancer activities in different tumors, alone or as an adjuvant with other antitumor drugs to prevent or inhibit the survival and cancer progression by various mechanisms. The role of curcumin in overcoming drug resistance was followed by reviewing different applications of curcumin in cancer therapy. Afterward, the clinical impacts of curcumin, role of curcumin in decreasing drug resistance in different cancer cells and its mechanisms were discussed. It has been demonstrated that curcumin regulates signaling pathways in cancer cells, reduces the expression of proteins related to drug resistance, and increases the performance of antitumor drugs at various levels. Curcumin reverses multidrug resistance mechanisms and increases sensitivity of resistance cells to chemotherapy. This review mainly focuses on different mechanisms of drug resistance and curcumin as a nontoxic natural substance to eliminate the effects of drug resistance through modulation and controlling cell resistance pathways and eventually suggests curcumin as a potent chemosensitizer in cancers.

Benefits Of Turmeric You Might Not Have Known
republicworld, May 2020
Turmeric is rich in curcumin; it can reduce inflammation by blocking enzymes that cause tissue inflammation. Curcumin has powerful antioxidant effects. It helps to reduce or even prevent some of the potential damage that free radicals can cause. According to recent research by Healthline, turmeric's antioxidant and anti-inflammatory capacity mostly related to its compound curcumin may play a role in weight loss.

Chemopreventive effect of green tea and curcumin in induced oral squamous cell carcinoma
Alexandria Dental Journal, May 2020
Curcumin, a natural polyphenol, is one of the most investigated biomolecules from Mother Nature. Curcumin has been shown to exert significant growth inhibitory effect on oral precancerous and carcinoma cell lines, and the effect is synergistic with epigallocatechin gallate, the most abundant polyphenol in tea. Conclusions: Green tea and curcumin have a significant chemopreventive effect against oral cancer.

Investigation of phytochemical screening and antimicrobial activity of Curcuma longa
International Journal of Advanced Research in Biological Sciences, May 2020
Many plants have been screened for antimicrobial activity and drug properties. The aim of the present study encourages the use of spices as alternative or supplementary medicine to reduce the burden of high cost, side effects and progressively increasing drug resistance of pathogens. In present study methanol and chloroform extracts of Curcuma longa (fresh and dry) were prepared from the rhizome. The antimicrobial properties of both of the extract were studied by testing the antibacterial as well as antifungal activity. The antibacterial test was done by agar well diffusion method against bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Protease vulgaris, Pseudomonas aeruginosa, Bacillus cereus, Bacillus megatarium, Bacillus subtilis and fungal species such as Aspergillus niger. The zone of inhibition of the extract were determined and compared with the standard drug streptomycin to know the efficiency. The methanol extract of rhizome was found to be more effective when compared with other solvent like chloroform. The phytochemical analysis of both of the extract revealed the presence of alkaloids, flavonoids, terpenoids, tannins, saponin and steroids.

Protective effects of curcumin on bleomycin-induced changes in lung glycoproteins
Molecular and Cellular Biochemistry, May 2020
Curcumin inhibited the increases in complex carbohydrates and glycosidases in the fibrotic lungs. These findings suggest that BLM-induced lung fibrosis is associated with accumulation of glycoproteins, and curcumin has the ability to suppress the enhanced deposition of glycoproteins in the fibrotic lung.

Nutrition: Is turmeric good for you?
newtimes, May 2020
They say turmeric and its most active compound known as curcumin has many scientifically-proven health benefits, such as the potential to prevent heart disease, Alzheimer’s and cancer, as well as a potent anti-inflammatory and antioxidant. Nutritionists say the primary active component of turmeric and the one that gives the spice its characteristic yellow colour is curcumin. In fact, they say that one can credit curcumin as the compound responsible for most of turmeric’s potential health benefits. Studies have shown that curcumin found in turmeric is an effective anti-carcinogen, a substance that helps prevent cancer. Besides, Uwiragiye notes that the medicinal property in turmeric is able to boost the immune system, even in people with immune disorders. During this time when we are faced with the novel coronavirus, it’s essential for people to consume foods that help in boosting their immunity, and turmeric should be one of them. This is because it has been proven that the virus affects people with the low immune system more. Research shows that the curcumin found in turmeric may help prevent Alzheimer’s, and, turmeric’s antioxidants prevent damage that can lead to Alzheimer’s. Meanwhile, studies have proven that curcumin in turmeric may help treat and prevent diabetes as well as associated disorders like diabetic nephropathy (also called diabetic kidney disease), which affects people with type 1 and 2 diabetes.

Effects of Curcumin on the Renal Toxicity
Antioxidants, May 2020
Curcumin (CURC), due to its therapeutic effects, has been chosen for our study to reduce the toxic renal effects induced by OTA. This study shows that curcumin can mitigate OTA-induced oxidative damage in the kidneys of rats.

COVID-19: Scientific Review with Natural & Holistic Methods for Immune Boosting
ModernHana, April 2020
CURCUMIN This chemical from the Indian spice, Tumeric, does many good things for the body. Kang et al 2019 study titled Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages” published in the British Journal of Pharmacology suggest that Curcumin can likely help reduce excess inflammation (cytokine storm) in the lungs. Jagetia GC and Aggarwal BB , 2007 study titled “ "Spicing up" of the immune system by curcumin” published in the Journal Clinical Immunology also suggests that Curcumin has potent immune benefits that can help fight infections.

A cost-effective preventative approach to potentially save lives in the coronavirus pandemic, jointly using Vitamin D, Curcumin, and Vitamin C
NutriXiv, April 2020
In the current absence of specific pharmaceutical agents, we propose assessing the extended tools that we already possess in our biological armoury to combat, prevent and control the spread of this virus. Using a set of precise criteria to locate such possible contenders, we conducted literature searches to find compounds that met these criteria. We have now reduced this to a shortlist of three agents that may be the best candidates. We propose vitamin C, vitamin D and Curcumin fit our criteria well. These compounds are widely available to the general public. They are available online and over-the-counter as supplements. Otherwise healthy individuals are safely able to self-administer these agents as a prophylactic to protect themselves and to enhance their immune response. This would be especially desirable for the elderly and at risk groups. These agents can also be used as adjunct therapy, particularly for those who may have early symptoms. This preventative therapy could be implemented whilst awaiting specific pharmaceutical drugs to emerge as a treatment for COVID-19. Our suggested compounds are a highly cost-effective way to potentially reduce the mortality that is regretfully mounting as a result of COVID-19 infection.

Enhance Your Immunity Amid Coronavirus Crisis
Medical Daily, April 20
"Turmeric has antiseptic, analgesic and immune boosting properties (that serve) as a line of defense against colds, flu and inflammation due to the active polyphenol called curcumin," Amanda Griggs, nutritionist at the Khera-Griggs Cleanse Clinic at the Urban Retreat in London, explained.

 Application of curcumin and its derivatives in tumor multidrug resistance
Phytotherapy Research, April 2020
Curcumin (CUR) has not only antitumor activity but also reversing tumor MDR effect. CUR reverses tumor MDR via regulating related signal pathways or corresponding expressed proteins or gene. When combined with chemotherapeutic agents, CUR can be a chemotherapeutic sensitive agent to enhance chemotherapy efficacy and weaken tumor MDR.

Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen
Nutrients, April 2020
Dietary supplementation with curcumin has been previously reported to have beneficial effects in people with insulin resistance, type 2 diabetes (T2D) and Alzheimer’s disease (AD). Dietary supplementation with curcumin reduced circulating levels of IAPP and GSK-3β, thus suggesting a novel mechanism through which curcumin could potentially be used for alleviating insulin resistance related markers for reducing the risk of T2D and AD.

Curcumin Reverses the Scopolomine-induced Cognitive Impairment
International Journal of Pharmaceutical Sciences and Drug Research, April 2020
Curcumin is a polyphenolic compound, known for its antioxidant, anti-inflammatory, neuroprotective, and precognitive properties. Present study reported that curcumin showed anti-amnesic effect in animal models of cognitive impairment of schizophrenia. Curcumin reduced the TL compared to toxic control group (scopolamine per se) (P <0.001) in elevated plus maze. In spontaneous alteration behaviour test, curcumin significantly increased percentage alteration and possible alteration as compared to toxic control group (P <0.001). The present study put forward the claim of curcumin as a new and safer therapeutic option for the treatment of cognitive impairment in Schizophrenia. The underlying mechanism of this potential effect may be related to anticholinesterase and nitric oxide synthase inhibition activity of curcumin.

Curcumin and Endometriosis
International Journal of Molecular Sciences, April 2020
Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

Type 2 diabetes: Curry spice to add to foods to lower blood sugar
Express, April 2020
A scientific paper from the Beijing University of Chinese Medicine and McGill University reviewed studies of how curcumin from the around the world could help with better type 2 diabetes management. In many of the studies it was found that curcumin reduced blood sugar and cholesterol levels for those with diabetes. Curcumin was found to improve insulin function which reduces insulin resistance by helping them enter the cells needed to repair and do its function. On top of helping lower blood sugar levels and improve insulin functions, curcumin was also found to be an excellent weight loss booster. Health experts found that curcumin prevented liver fat accumulation in studies on rats. It found that rats who consumed curcumin had reduced liver fat on a high-fat diet compared to rats not consuming curcumin and aided in weight loss. One of the best type 2 diabetes management one could do is lose weight if overweight and curcumin could help with this. The studies also found that curcumin helped to fight off cancers and even helped those suffering with erectile dysfunction.

Ward off your cancer risk with spices
The Health Site, April 2020
Good old turmeric is your has been your kitchen companion forever. Almost all your dishes have turmeric in them. The good news is, curcumin, a component of turmeric can reduce your cancer risk, finds a spate of studies. A study published in the journal Gastroenterology found that this compound prevented the growth of colon cancer tumours. Curcumin is also known to protect you from other Alzheimer’s, diabetes, arthritis pain, etc.

Coronavirus Pandemic: Here’s How to Boost Your Immunity at Home
News18, March 2020
Turmeric: A common spice in India and Asia. Turmeric contains curcumin which is known to enhance immune function. Adding turmeric to your food will help you boost your immunity.

Tips on Staying Safe During the COVID-19 Outbreak by a Doctor
The Quint, March 2020
The active ingredient curcumin has been shown in several studies to stop the ‘cytokine storm’ of pro-inflammatory chemicals in the body, in the earlier epidemics of SARS and Ebola viruses.

What can I do to boost my immunity? Is there any medication able to treat coronavirus? COVID-19 questions answered by Cleveland Clinic doctor
WKYC, March 2020
Dr. Roizen: There are a lot of things that boost immunity. Vitamin D is one of those reported to boost immunity. Curcumin is reported to boost it.

A recent study by Indonesia's Airlangga University suggested curcumin — a component of turmeric — could reduce inflammation in the lungs and help boost immunity against the virus.
ABC, March 2020

Protect your body against coronavirus
InfoSurhoy, March 2020
Consuming anti-inflammatory rich foods is essential when it comes to the immune system.. The compound in turmeric known as curcumin holds a plethora of benefits.

Precaution and prevention best medicines to avoid Covid-19
Times of India, March 2020
Dr Varinder and Dr Naveen Airi specified that there there is no treatment for Coronavirus. The only way to prevent is to boost immunity via homeopath medicines like Ginseng, Curcumin

Turmeric, or curcumin, known for reducing inflammation in the body, can help fight off coronavirus, according to some medical experts
IndiaWest, March 2020
NEW DELHI – Turmeric, or curcumin, is being advocated by some medical experts for reducing lung inflammation amid the rising COVID-19 cases in India. The virus is especially known to attack the respiratory system. Turmeric is being touted as the only way to keep inflammation in your body low so that you have a better chance of fighting the coronavirus infection.

"Curcumin (a diferuloylmethane) was found to be the most widely studied compound as evinced by more than 9000 citations in the literature, with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, antidiabetic, antiarthritic, antiatherosclerotic, antidepressant, antiaging, antimicrobial, wound healing and memory-enhancing activities. Moreover, it exerts chemopreventive, chemosensitization and radiosensitization effects as well. In traditional Indian medicine, this spice has been also used to treat different ailments such as gynecological problems, gastric problems, hepatic disorders, infectious diseases, blood disorders, acne, psoriasis, dermatitis, rash and other chronic ailments. Diverse in vivo studies have also indicated its potential against pro-inflammatory diseases, cancers, neurodegenerative diseases, depression, diabetes, obesity and atherosclerosis. Besides its safety and tolerability, cost-effectiveness is an added advantage of this compound. To date, over 100 different clinical trials have been completed with curcumin, which clearly show its safety, tolerability and its effectiveness against various chronic diseases in humans." - British Journal of Pharmacology

"7,000 published articles have shed light on the various aspects of curcumin including its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer activities. Oxidative stress and inflammation play a pivotal role in various diseases like diabetes, cancer, arthritis, Alzheimer's disease and cardiovascular diseases." - Food and Chemical Toxicology Journal

"6.000 articles published within the past two decades have discussed the molecular basis for the antioxidant, anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer activities assigned to this nutraceutical. Over sixty five clinical trials conducted on this molecules, have shed light on the role of curcumin in various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer." - Biotechnology Advances Journal

"Curcumin has been used as pharmacological traditional medicinal agent in Ayurvedic medicine for 6000 years. The current review article presents effective role of curcumin against cancer, diabetes, oxidative stress, cardiovascular, obesity, and aging. Curcumin is a promising and significant natural bioactive compound which has been shown to possess numerous pharmacological activities including anticancer, antidiabetic, cardiovascular protective, antiobesity, antimicrobial, wound healing, and nephroprotective activities. The molecule has also potential to protect from reproductive and respiratory disorders in association with its strong antioxidant potential. In near future, curcumin is expected to be proven as a novel drug to treat and cure several human disorders such as carcinogenesis, inflammatory disorders, and oxidative stress-induced pathogenesis." - Trends in Food Science & Technology

Turmeric to resist COVID-19
Saxon, March 2020
Turmeric. Its main component curcumin is considered a powerful immune booster, acts as an anti-inflammatory.

Curcumin Inhibits the Tumorigenesis of Breast Cancer
Cancer Management and Research, March 2020
Curcumin is an active phenolic pigment that is isolated from turmeric (Curcuma longa).  Curcumin has diverse properties on tumor cells, including anti-proliferation, anti-inflammatory, and anti-oxidant.  Previous studies have shown that curcumin can effectively suppress the invasion and proliferation of human cancers, such as wilms’ tumor (WT) esophageal cancers, and pancreatic cancer. Jia et al have found that the proliferation, invasion and migration of WT cells are restrained by the treatment of curcumin. Dharmalingam et al have shown that curcumin treatment inhibits the proliferation and colony formation of esophageal cancer cells in a dose and time-dependent manner. Choudhuri et al have proved that curcumin induces the apoptosis of BC cells. In addition, Bang and Kim have confirmed that curcumin significantly inhibits the motility and invasion of BC cells. The anti-tumor role of curcumin has been identified by a large number of researches.  Curcumin (20 and 30 μM) inhibited the proliferation, migration and invasion, and promoted the apoptosis of MCF-7 and MDA-MB-231 cells. Curcumin decreased the protein expression of TAZ and YAP in MCF-7 and MDA-MB-231 cells. Overexpression of YAP reversed the anti-tumor effect of curcumin on MDA-MB-231 cells. In addition, curcumin (100, 200 and 300 mg/kg/d) inhibited the growth of tumor xenografts in mice, and down-regulated the protein expression of TAZ and YAP in tumor xenografts. Curcumin at a concentration of 300 mg/kg/d slowed the increasing of body weight in mice. Conclusion: Curcumin inhibited the tumorigenesis of BC by blocking TAZ/YAP axis

Curcumin and Colorectal Cancer: An Update and Current Perspective On This Natural Medicine
Seminars in Cancer Biology, March 2020
Curcumin, derived from the plant Curcuma longa, represents one such option that has a long history of its use for a variety of chronic disease including cancer, in Indian ayurvedic and traditional Chinese medicine. Scientific evidence over the past few decades have overwhelmingly shown that curcumin exhibits a multitude of anti-cancer activities orchestrated through key signaling pathways associated with cancer. In this article, we will present a current update and perspective on this natural medicine - incorporating the basic cellular mechanisms it effects and the current state of clinical evidence, challenges and promise for its use as a cancer preventative and potential adjunct together with modern therapies for CRC patients.

Therapeutic Effects of Curcumin against Bladder Cancer
Anti-Cancer Agents in Medicinal Chemistry, March 2020
Curcumin is a well-known plant-derived polyphenol found in turmeric. This compound has numerous pharmacological effects such as antioxidant, anti-inflammatory, anti-diabetic and anti-tumor properties. Curcumin is capable of suppressing the growth of a variety of cancer cells including those of bladder cancer. Given the involvement of various signaling pathways such as PI3K, Akt, mTOR and VEGF in the progression and malignancy of bladder cancer, and considering the potential of curcumin in targeting signaling pathways, it seems that curcumin can be considered as a promising candidate in bladder cancer therapy. In the present review, we describe the molecular signaling pathways through which curcumin inhibits invasion and metastasis of bladder cancer cells.

Coronavirus: Antiviral Cationic Carbon Dots Based on Curcumin
ACS Publications, March 2020
Here, we report a one-step method to apply curcumin in order to prepare of uniform and stable cationic carbon dots (CCM-CDs) with antiviral properties. These results offer theoretical support for the development of CCM-CDs as a hopeful antiviral drug for the treatment of coronavirus infections, including PEDV.

In the fight against cancer: Scientists say compound curcumin found in the popular spice has tumour-killing potential
DailyMail, March 2020
Scientists analyzed almost 5,000 studies and found curcumin blocked the growth of eight types of cancers, under laboratory settings. Results showed it was effective at treating breast, lung, blood, stomach, pancreatic, bowel, bone marrow and prostate cancer. The academics from Temple University in Philadelphia say curcumin stops nutrients from being transported to tumours.It also prevents the death of healthy cells by blocking cancer cells from releasing harmful proteins. The academics concluded curcumin - the pigment in turmeric that gives it its colour - could 'represent an effective drug for cancer treatment.

Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity
ACS Infectious Diseases, March 2020
Orally applied curcumin was detected in the brain, cerebellum, and sciatic nerve. Co-administration of oral curcumin markedly improved colistin-induced impaired sensory and motor dysfunctions in a dose-dependent manner. Curcumin supplementation at 100 and 200 mg/kg significantly decreased lipid peroxidation and upregulated catalase (CAT) and superoxide dismutase (SOD) activities, ATP levels, and Na+/K+-ATPase activity in sciatic nerve tissue, compared to the colistin alone group. Curcumin supplementation at 200 mg/kg upregulated the levels of AKT, NGF, mTOR, Nrf2, and HO-1 mRNA and concomitantly downregulated Bax, caspases-3, and -9 mRNA; it also decreased caspase-3 and caspase-9 activity. In summary, for the first time, our study reveals that the protective effect of oral curcumin on colistin induced peripheral neurotoxicity is associated with the activation of NGF/Akt and Nrf2/HO-1 pathways and inhibition of oxidative stress. This study highlights the potential clinical application of curcumin as an oral neuroprotective agent coadministered during colistin therapy.

Curcumin attenuates copper-induced oxidative stress and neurotoxicity
Toxicology Reports, March 2020
Curcumin is a hydrophobic polyphenol derived from the rhizome of the Herb Curcuma longa belonging to the family Zingiberaceae. Curcumin possesses antioxidative, anti-inflammatory and anti-depressant-like properties.  Our findings suggest that Curcumin ameliorated Cu2+-induced neurotoxicity in D. melanogaster and as such could be considered an effective therapeutic agent in the prevention and treatment of disorders, where oxidative stress is implicated.

Antioxidant, Anti-Inflammatory, and Antiapoptotic Potential of Curcumin in Benzo(a)pyrene (BaP)-Induced Lung Injury
Journal of Thoracic Oncology, March 2020
Curcumin (Cur) has potent anti-inflammatory, antioxidant activity that defences cells from oxidative stress and cell death.  Thus, curcumin may be an alternative therapy for improving the outcomes of Benzo(a)pyrene -induced lung injury.

Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury
Molecules, March 2020
Curcumin is an active ingredient of Curcuma longa, and it has potent anti-inflammatory, antioxidant activity that defends cells from oxidative stress and cell death. Overall, our findings suggest that curcumin attenuates BaP -induced lung injury, probably through inhibiting inflammation, oxidative stress and apoptosis in lung epithelial cells, and improving cell proliferation and antioxidants level.

Ease Joint Pains Caused By Arthritis By Using This Spice Extract
IB Times, March 2020
Long praised for its anti-inflammatory properties, turmeric is becoming the focus of various studies on pain alleviation. The key ingredient of this popular Asian spice is curcumin, an active compound found in this flowering plant. A review summary of various controlled tests found that a thousand milligrams per day of curcumin can reduce osteoarthritic inflammation and pain. Its efficacy is comparable to that of non-steroidal anti-inflammatory drugs or NSAIDs like ibuprofen and diclofenac. In another study conducted in 2016, results show that curcumin may help prevent the breakdown of bones in people with rheumatoid arthritis. You must choose curcumin extract over the whole turmeric, according to the Arthritis Foundation.

Curcumin on Improving Cognitive Function in an Alzheimer’s Disease
Neurochemical Research, March 2020
Berberine and curcumin are extracts from traditional Chinese herbs that have a long history of clinical benefits for Alzheimer’s disease. Here, using a transgenic Alzheimer’s disease mouse model, we found that the combined berberine and curcumin treatment had a much better effect on improving the cognitive function of mice than the single-drug treatment, suggesting synergic effects of the combined berberine and curcumin treatment. In addition, we found that the combined berberine and curcumin treatment had significant synergic effects on reducing soluble amyloid-β-peptide(1–42) production. Furthermore, the combination treatment also had remarkable synergic effects on decreasing inflammatory responses and oxidative stress in both the cortex and hippocampus of Alzheimer’s disease mice. We also found that the combination treatment performed much better than the single drugs in reducing the APP and BACE1 levels and increasing AMPKα phosphorylation and cell autophagy, which might be the underlying mechanism of the synergic effects. Taken together, the result of this study reveal the synergic effects and potential underlying mechanisms of the combined berberine and curcumin treatment in improving the symptoms of Alzheimer’s disease.

Bidirectional interactions between curcumin and gut microbiota in transgenic mice with Alzheimer’s disease
Applied Microbiology and Biotechnology, March 2020
Curcumin administration tended to improve the spatial learning and memory abilities and reduce the amyloid plaque burden in the hippocampus of APP/PS1 mice. On the one hand, curcumin administration altered significantly the relative abundances of bacterial taxa such as Bacteroidaceae, Prevotellaceae, Lactobacillaceae, and Rikenellaceae at family level, and Prevotella, Bacteroides,a nd Parabacteroides at genus level, several of which have been reported to be key bacterial species associated with Alzheimer’s disease development. On the other hand, a total of 8 metabolites of curcumin biotransformed by gut microbiota of Alzheimer’s disease mice through reduction, demethoxylation, demethylation and hydroxylation were identified by HPLC-Q-TOF/MS, and many of these metabolites have been reported to exhibit neuroprotective ability. The findings provided useful clues to understand the pharmacology of curcumin and microbiome-targeting therapies for Alzheimer’s disease.

Best Supplements To Take For Better Brain Health
Medical Daily, March 2020
Turmeric is potent anti-inflammatory, as such it has already shown potential in animal studies to reduce or help prevent brain cell damage. Taking tumeric helps supplement DHA (docosahexaenoic acid) deficiency, which can make people more prone to cognitive disorders. Curcumin, the compound present in turmeric, helps in the synthesis of DHA, therefore providing neuroprotection.

Inhibitory Effect of Curcumin on Artery Restenosis
Drug Design, Development and Therapy, March 2020
Curcumin is a natural phenolic substance extracted from the rhizome of the plant Curcuma longa. Turmeric is commonly present in ordinary diets and its traditional use for the treatment of various diseases in China originates from several eons ago. Extensive investigations indicate that Cur has diverse pharmacological effects, such as antiinflammatory, antioxidant, antiproliferative and anticarcinogenic, whereas it also protects against the development of cerebrovascular diseases. Curcumin provides these beneficial effects due to its ability to regulate certain molecular targets, including adhesion molecules, growth factors, transcription factors, and factors involved in proliferation and apoptosis that are associated with several different cell types. Certain studies have shown that Curcumin can inhibit the proliferation of VSMCs and prevent stent restenosis following angioplasty. Curcumin inhibited the proliferation of smooth muscle cells and neointimal formation and reduced the inflammation and oxidative stress indices. Concomitantly, Curcumin reduced the phosphorylation of the Raf/MEK/ERK pathway proteins. Conclusion: Curcumin could inhibit carotid restenosis following CEA by inhibiting the activation of the Raf/MEK/ERK pathway.

Boost Your Immunity
Today Online, March 2020
The healing benefits of turmeric have been widely documented. Used in India for centuries as a spice and medicinal herb, turmeric contains curcumin, a potent antioxidant that can help neutralise free radicals, and also natural anti-inflammatory compounds, which help your body fight pathogens and repair damage.

Healthy Foods for Your Liver
Livestrong, March 2020
Turmeric is having its day in the sun thanks to it being a potent source of curcumin, a powerful antioxidant. Curcumin helps to reduce oxidative stress by neutralizing the harmful components of oxidative stress, according to July 2018 research published in Nutrients. Why's this important? Our daily routines can really wreak havoc on the liver: Alcohol and medications — even over-the-counter meds — can cause stress on the liver. And it's not just any run of the mill stress; it's oxidative stress. Chronic oxidative stress could mean liver damage if it's not addressed. Curcumin also has a hepatoprotective effect on the liver, which means it can prevent liver damage thanks to its anti-inflammatory properties.

Mutual Two-Way Interactions of Curcumin and Gut Microbiota
The International Journal of Molecular Sciences, February 2020
Curcumin is a natural phenolic component derived from the Curcuma longa plant and has been used in India to treat inflammation. Due to its chemical structure, this molecule can be used in several different areas, such as food, textiles and the pharmaceutical industry. Curcumin is widely used as a spice and dye in food products with a characteristic yellow color; therefore, it is consumed daily. Curcumin is a spice that has recently gained great interest and is widely used in Ayurvedic medicine. Curcumin is a promising compound that is easily available and easy to use in the diet, and it is also safe and affordable. Currently available data provide evidence that curcumin has antitumor activity, induces neuroprotection and neurogenesis, and can be a new therapeutic agent in both regenerative medicine and neurodegenerative diseases, such as post-ischemic neurodegeneration and Alzheimer’s disease.

Protective Effects of Curcumin Against Nephrotoxic Agents
Cardiovascular & Hematological Disorders-Drug Targets, February 2020
Curcumin is the one of the main phenolic ingredients in curcuma species rhizome. Curcuma species have traditionally been used for the treatment of diabetes, cardiovascular, and renal diseases. Studies have shown the protective effects of curcumin against nephrotoxic agents such as gallic acid, glucose, tartrazine, streptozotocin, lead, cadmium, fluoride, maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate. The current review indicated that curcumin may be effective against nephrotoxicity by modulating oxidative stress and inflammatory responses.

Benefits of Turmeric
University of Utah, February 2020
Researchers have found that phytochemicals from natural foods, such as the curcumin found in turmeric, may be a safe and effective way to help reduce inflammation and prevent and treat disease. While acute inflammatory responses are beneficial for the body in that they help heal injury, irritation, or infection, we know that chronic inflammation can contribute to disease onset. There is promising research to support curcumin’s use for the anti-inflammatory and antioxidant effects on obesity, to reduce arthritis pain and swelling, and to aid in complications such as diabetic retinopathy, nephropathy, and cardiomyopathy.

Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer
Drug Design, Development and Therapy, February 2020
Curcumin has potential therapeutic effect on treating tongue cancer  by suppressing cell proliferation and migration, as well as promoting apoptosis through modulating oxygen-related signaling pathways.

Add This Spice To Your Diet To Improve Your Chances In Fighting Cancer
IB Times, February 2020
Today, scientists reveal that this unassuming plant contains curcumin, a compound that can kill a tumor and stop the proliferation of cancer cells. Researchers conclude turmeric may soon become an effective anti-cancer drug due to the antioxidant and anti-inflammatory powers of curcumin. They reveal that curcumin has shown great potential in killing cancer cells in particular types of cancer. Scientists, however, stopped short in saying they already found the cure for cancer. They admitted more research is needed to establish the cancer-stopping potential of the turmeric compound firmly. For now, it appears that curcumin has achieved considerable success in killing cancer cells and stop the unabated growth of rogue cells. It also has shown greater efficacy in dealing with stomach cancer, breast cancer, skin cancer, and bowel cancer cells.

Effect of curcumin supplementation on disease severity in patients with liver cirrhosis
Phytotherapy Research, February 2020
Recent reports indicated that curcumin had beneficial effects in animal models of liver injury and cirrhosis. Current study aimed to investigate the effects of curcumin supplementation in patients with liver cirrhosis. In this pilot study, beneficial effects of curcumin supplementation were observed in decreasing disease activity scores and severity of cirrhosis in patients with cirrhosis.

One Spice Can Help You Lose The Nasty Visceral Fat
IB Times, February 2020
According to an Express report, the fat-burning benefits of turmeric stems from curcumin. This is the chemical that is found in turmeric and has been linked to weight loss. In a study that involved 44 overweight people, the researchers found that when they take curcumin even just twice in a month, they noticed how effective it was in aiding the process of weight loss. It was attributed to a decrease in belly fat. It also helped reduce weight. Aside from the study involving the 44 individuals, a separate study on mice showed that mice that were given curcumin for 12 weeks showed a reduction in body weight. They found out that it blocked the synthesis of fat. Combining the results of both studies, it would show how effective curcumin is in weight loss.

Superfoods & cancer risks
Deccan Herald, February 2020
Curcumin is an antioxidant found in turmeric. It helps the body to fight against HPV and protect against cervical cancer by slowing down or limiting the activity of the virus.

The In-Vitro Effect of Curcumin and Arsenic Trioxide on The Level Of NF-kB and Induction of Apoptosis in B16 Cell Lines
Karbala Journal of Medicine, February 2020
Curcumin is a natural product that had been utilized for a variety of maladies like rheumatic, cardiac, neurological and numerous other disorders. Curcumin had very potent concentration dependent anti-cancer effects against B16 MM cell line.

CBD and Turmeric – Why This Is A Great Combination
prospercbdnews.com, February 2020
Turmeric, the spice also known as Indian saffron, comes from the Ginger family. It has several properties that overlap those of cannabidiol which is what makes it a wonderful addition to CBD products. Turmeric has been used in Ayurvedic practices for centuries. It has a therapeutic nature and several medicinal applications. Being a strong anti-inflammatory agent, turmeric improves brain, heart, and joint health. The curcumin in turmeric is where its strength lies.

Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway
Drug Design, Development and Therapy, February 2020
Curcumin attenuates oxaliplatin-induced liver injury and oxidative stress by activating the Nrf2 pathway, which suggests that CUR may be potentially used in the prevention and treatment of OXA-induced liver injury.

Adding Curcumin to Mesalamine May Benefit Patients With Ulcerative Colitis
empr.com, February 2020
Adjunctive therapy with curcumin was found to provide a greater clinical benefit than placebo in patients with ulcerative colitis (UC) being treated with mesalamine, according to the findings of a recently published systematic review and meta-analysis. The study authors reported that the odds of clinical response were approximately threefold better for patients who received the combination of mesalamine plus curcumin vs placebo.“This response was statistically significant, albeit with heterogeneity, probably due to the different severity scoring indices, curcumin dosages and routes of drug delivery used,” the authors stated. They added, “Given the minimal adverse events, we recommend that curcumin be considered as an adjunct to mesalamine in the treatment of UC."

Effect of curcumin on expression of μ opioid receptors
Civilica.com, February 2020
Recent studies have shown that curcumin, the active ingredient of turmeric, reduces the symptoms of withdrawal syndrome in morphinedependent mice. Treatment with curcumin resulted in a significant and dose-dependent attenuation of withdrawal syndrome along with a decrease in the expression of spinal μ opioid receptors in morphine-dependent rats. The maximum effect was obtained from curcumin at the dosage of 10 mg/kg.  The results of this study indicate that curcumin is capable of attenuating morphine dependence in rats through decreasing the expression of spinal opioid μ receptors.

Curcumin supplementation improves heat-stress-induced cardiac injury
The Journal of Nutritional Biochemistry, February 2020
Curcumin may increase animal survival and lifespan under heat stress.  Our results indicated that curcumin supplementation could alleviate HS-induced physiological disorders and the increasing of cTn-I and Ang II. The expression of AT1 gene in HT group was significantly higher than that of curcumin groups, indicating the cardioprotective effects of curcumin. Moreover, the levels of GRP78 and CHOP proteins in the HT group were significantly higher than those of curcumin groups, indicating that curcumin supplementation reversed the endoplasmic reticulum HS-mediated apoptosis. In summary, curcumin supplementation alleviates physiological stress and cardiac damage caused by HS.

Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population
Nutrients, February 2020
Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also anti-inflammatory properties. This effect of curcumin could improve Exercise-Induced Muscle Damage and exercise performance. The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day before and during exercise, and up until 72 hours post-exercise, improved performance by reducing EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to be able to tolerate high doses of curcumin without significant side-effects.

Curcumin and Cancer
Nutrients, January 2020
Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the most described and still remains under investigation. The present review focuses on the cell signaling pathways involved in cancer development and proliferation, and which are targeted by curcumin. Curcumin has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins. This polyphenol compound, alone or combined with other agents, could represent an effective drug for cancer therapy.

How turmeric could offer hope in the fight against CANCER: Scientists say compound curcumin found in the popular spice has tumour-killing potential
DailyMail, January 2020
A compound found in turmeric could unlock new treatments in the battle against cancer, a scientific review has suggested. Researchers say the anti-inflammatory and antioxidant powers of curcumin mean it could halt the development of tumours. They analysed almost 5,000 studies and found it blocked the growth of eight types of cancers, under laboratory settings. Results showed it was effective at treating breast, lung, blood, stomach, pancreatic, bowel, bone marrow and prostate cancer.

Curcumin, a compound found in turmeric, could ‘halt tumour development’, major study says
College Of Medicine, January 2020
New scientific research has found that a common compound found in the spice turmeric could stop cancerous tumours from growing further. A study, carried out by academics at Temple University in Philadelphia, and published in the Nutrients journal, found the antioxidant and anti-inflammatory properties of curcumin halted the development of eight different types of cancer. Analysing nearly 5,000 studies, researchers said the compound – which gives turmeric its bright orange colour – was effective at treating pancreatic, bowel, bone marrow, prostate, breast, lung, blood and stomach cancer. Results showed nutrients that the tumours needed to thrive were halted by curcumin, which also blocked harmful proteins produced by cancer cells. The study’s lead scientists concluded that the compound could ‘represent an effective drug for cancer treatment, alone or combined with other agents’. Dr Antonio Giordano, a pathologist at Temple University, lead a team who looked at almost 13,000 studies carried out on curcumin since 1924, focusing specifically on 4,738 studies that looked at how the compound affected cancer. The study’s authors said: “The search for new effective drugs able to combat cancer diseases still represents a challenge for many scientists. “Natural organisms (e.g., plants, bacteria, fungi) provide many active molecules with a potential application in medicine for the management of many diseases. “As reported in the present review, curcumin exhibits anticancer ability by targeting different cell signaling pathways including growth factors, [the transport of nutrients and killing healthy cells].”

Curcumin, as a potent anticancer agent for the treatment of breast cancer
First International Conference on Management of Agricultural Sciences, January 2020
Curcumin, an orange-yellow component of turmeric or curry powder, is a highly pleiotropic molecule which shows promising effects on various pro-inflammatory diseases, inflammatory conditions, hepatic conditions, metabolic syndromes, degenerative eye conditions, etc. Over the past decades, numerous studies have demonstrated that curcumin has several anticancer effects in various types of cancers, including breast cancer.Materials and Methods: In the present review, we aimed to investigate the role of curcumin on the treatment of breast cancer. For this purpose, we searched scientific databases including Scopus, Pubmed, Clinical key, etc.Results: The growth inhibitory effect of curcumin has been studied on different models of breast cancer. Our findings showed that curcumin inhibits the growth of breast cancer cells by suppressing cell proliferation and metastasis and inducing cell death without no toxicity to normal cells. Importantly, curcumin treatment increases the effectiveness of chemotherapy and decreases the number of cancer stem cells. There are studies showing that the ability of curcumin to reduce chemoresistance tumor cells, to inhibit the reattachment of BCSCs, and to prevent the migratory ability of Breast cancer stem cells.Conclusion: Based on our findings, it is recommended that the use of curcumin can have beneficial effects on the survival rates of patients with breast cancer.

Curcumin compound in turmeric could help beat cancer
The Saxon, January 2020
Academics from Temple University in Philadelphia say curcumin stops nutrients from being transported to tumours. It also prevents the death of healthy cells by blocking cancer cells from releasing harmful proteins. The academics concluded curcumin – the pigment in turmeric that gives it its colour – could ‘represent an effective drug for cancer treatment, alone or combined with other agents’.

7 Fitness-Supporting Supplements That Get The RDN Stamp Of Approval
MindBodyGreen, January 2020

As the active ingredient in turmeric root, curcumin is a powerful antioxidant and anti-inflammatory that has been shown to help reduce stress from physical activity. Think of this potent yellow spice as an herbal aid in recovery: "Studies show curcumin may relieve joint discomfort associated with exercise or overuse," says Blakely, "which can help you get back in the gym for your next workout faster."

Curcumin, as a pleiotropic agent, improves doxorubicin-induced nephrotic syndrome in rats.
Journal of Ethnopharmacology, January 2020
Curcumin, a phenolic compound extracted from the rhizome of turmeric (Curcuma longa L.), has been reported to have broad biological functions including potent antioxidant and renoprotective effects. It has been reported that Curcumin has a certain protective effect on the kidney. The consequences of this study revealed that curcumin activated Nrf2, inhibited NF-κB pathway and up-regulated podocin in DOX-induced podocyte. Further research results showed that curcumin can considerably alleviate proteinuria and improve hypoalbuminemia in NS rats, and lower blood lipid levels to alleviate hyperlipidemia in NS rats, indicating that curcumin has significant therapeutic effects on rat NS. Further observation by electron microscopy and detection showed that curcumin can improve renal function and podocyte injury, which may be related to the repairment of mRNA expression and podocin protein. Interestingly, the results of the blood rheology test showed that curcumin can effectively reduce whole blood viscosity (WBV) and plasma viscosity (PV), and reduce hematocrit (Hct). In addition, the oxidative stress state of kidney in NS rats was considerably reversed by curcumin, which may be achieved by activating Nrf2 and increasing the expression of antioxidant enzymes HO-1, NQO-1. We also found that NF-κB pathway is activated in the kidney of NS rats, and curcumin can inhibit the activation of NF-κB by down-regulating the expression of NF-κB p65, reducing the level of p-IκBα and up-regulating the expression of IκBα. These findings suggest that curcumin, as a multifunctional agent, exerts a protective effect on DOX-induced nephrotic syndrome in rats, which provides a pharmacological basis for the further development of curcumin and also provides a basis for the advantages of multi-targeted drugs in the processing of NS.

Herbs That Help Alleviate Symptoms Of Chronic Obstructive Pulmonary Disease
ibtimes, January 2020
Turmeric contains a compound called curcumin which helps reduce airway inflammations. Curcumin is a very powerful antioxidant that helps combat oxidative stress underlying COPD by blocking inflammation at a molecular level. A 2009 study has reported that curcumin inhibits COPD-like airway inflammation and the progression of lung cancer. The findings of the study demonstrated that curcumin can be used to inhibit the progression of lung cancer in high-risk COPD patients. Several other pieces of research have pointed to curcumin’s antiviral, anti-inflammatory and antioxidant effects. This herb’s potential ability to fight or prevent cancer is intriguing.

 

Nutraceutical Activities of Turmeric (Curcuma longa) and its Bioactive Constituent Curcumin
Department of Biochemistry, CSIR, December 2019
In the past couple of decades, many health beneficial physiological effects of turmeric or its constituent ─ curcumin have been documented in experimental and/or clinical studies which suggest that consumption of this spice offers benefits beyond sensory attributes. Turmeric and curcumin have been shown to exert preventive and ameliorative influence on diabetes, cardiovascular disease, inflammatory disorders, and cancer. The antioxidant property of turmeric/ curcumin explains its diverse pharmacological potential. Curcumin effectively reduces lipid peroxidation through its antioxidant influence. Turmeric is traditionally employed as an anti-inflammatory drug. Experimental research indicates that curcumin suppresses both tumour initiation and promotion. The anticarcinogenic effect of curcumin is mediated through inhibition of the transcription factor NFkB and proinflammatory pathways. Curcumin induces apoptosis, and suppresses tumour proliferation and angiogenesis. The anticancer potential of curcumin is also evidenced in clinical studies.


"Curcumin supplementation modulated the gut microbiota composition and ameliorated intestinal dysbiosis by decreasing the ratio of Firmicutes/Bacteroidetes and endotoxin-producing Desulfovibrio bacteria and increasing the abundance of Akkermansia population and SCFA-producing bacteria, such as Bacteroides, Parabacteroides, Alistipes and Alloprevotella, along with increases in caecal and colonic SCFA concentrations. These dominant bacterial genera altered by curcumin showed strong correlations with the obesity-related metabolic parameters in HFD-fed mice. In conclusion, our data suggest that curcumin alleviated metabolic features of hepatic steatosis and insulin resistance in HFD-fed obese mice, which might be associated with the modulation of gut microbiota composition and metabolites." - Curcumin alleviates high-fat diet-induced hepatic steatosis and obesity in association with modulation of gut microbiota in mice | May 2021

"After oral administration, curcumin is distributed in the intestines, and then curcumin exerts its effects on the gut microbiota (such as microbial richness, diversity, and composition). Curcumin administration exerts significant effects on gut microbiota family such as Bacteroidaceae, Rikenellaceae, and Prevotellaceae. Moreover, curcumin significantly promoted gut microbiota, including Anaerotruncus, Exiguobacterium, Helicobacter, Papillibacter, Pseudomonas, Serratia, and Shewanella. Curcumin also ameliorates the intestinal barrier function (by modulating intracellular signaling and the organization of tight junctions) in metabolic diseases, as indicated by a reduced rate of bacterial translocation to the blood, liver, kidneys, and spleen. A study showed that administration of curcumin significantly reduced the Western-diet-induced blood lipopolysaccharide and ameliorated the intestinal barrier. Thus, it can be concluded that curcumin prevents metabolic diseases through a mechanism involved in the regulation of the intestinal barrier. Many studies suggest that curcumin can actively hinder intestinal inflammation by modulating the homeostasis of the gut-brain axis, and could also exhibit neuroprotective beneficial. Further, curcumin treatment decreases the microbial abundance of cancer-related species like Prevotella, Coriobacterales, and Ruminococcus. These help to exhibit antioxidative and anticancer properties." - Curcumin and Metabolic Diseases: The Role of Gut Microbiota, Nutrients | January 2021

"The remarkable effects of curcumin on isolated gut microbiota may explain the wide range of its beneficial effects. Several studies showed that curcumin has positive effects on several diseases by changing the distribution of some gut microbiota. This may be an important mechanism underlying therapeutic benefits of curcumin." -  Does Curcumin Have a Role in the Interaction between Gut Microbiota and Schistosoma mansoni in Mice,  Pathogens | September 2020

"Curcumin could exert direct regulative effects primarily in the gastrointestinal tract, where high concentrations of this polyphenol have been detected after oral administration. Consequently, it might be hypothesized that curcumin directly exerts its regulatory effects on the gut microbiota, thus explaining the paradox between its low systemic bioavailability and its wide pharmacological activities. Interestingly, curcumin and its metabolites have been shown to influence the microbiota. It is worth noting that from the interaction between curcumin and microbiota two different phenomena arise: the regulation of intestinal microflora by curcumin and the biotransformation of curcumin by gut microbiota, both of them potentially crucial for curcumin activity." - Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin, Nutrients | July 2020

"Curcumin, an herbal naturally occurring polyphenol, has recently been proposed for the treatment of neurodegenerative, neurological and cancer diseases due to its pleiotropic effect. Recent studies indicated that gut microflora may be a new potential therapeutic target. The new working hypothesis that could explain the curative role of curcumin, despite its limited availability, is that curcumin acts indirectly on the brain, affecting the “gut–brain–microflora axis”, a complex two-way system in which the gut microbiome and its composition, are factors that preserve and determine brain health. It is therefore suspected that curcumin and its metabolites have a direct regulatory effect on gut microflora and vice versa, which may explain the paradox between curcumin’s poor bioavailability and its commonly reported therapeutic effects. Curcumin and its metabolites can have health benefits by eliminating intestinal microflora dysbiosis. In addition, curcumin undergoes enzymatic modifications by bacteria, forming pharmacologically more active metabolites than their parent, curcumin. Curcumin is present in high concentrations in the gastrointestinal tract after oral administration. Given the pathogenic links between intestinal microflora and many diseases, current findings could help us interpret the therapeutic advantage of curcumin." - Mutual Two-Way Interactions of Curcumin and Gut Microbiota, The International Journal of Molecular Sciences | February 2020

"The present study demonstrated that curcumin could interact with gut microbiota in two directions. On one hand, curcumin exerted direct influence on the gut microbiota of curcumin, and it could normalize especially the relative abundance of several key bacterial taxa involved in Alzheimer’s disease development. On the other hand, gut microbiota could biotransform curcumin into a series of metabolites, which had been reported to possess neuroprotective effects. The findings not only interpreted the paradox between the pharmacological effect of curcumin and its poor bioavailability, but also implied that metabolites of curcumin biotansformed by gut microbiota might act as an important source to screen biologically active compounds to combat Alzheimer’s disease. Further, the interaction between curcumin and gut microbiota provided clues to elucidate the pharmacology of natural polyphenolic compounds, which was worthy of further study" - Bidirectional interactions between curcumin and gut microbiota, Applied Microbiology and Biotechnology | February 2020


"Curcumin represents one of the most studied herbal remedies, responsible for different pharmacological activities. The paradox of poor bioavailability of curcumin and the wide range of health effects of curcumin can be explained by considering the reciprocal influence existing between curcumin and gut microbiota. Curcumin in the gut favors the growth of beneficial bacteria strains such as Bifidobacteria and Lactobacilli, with reduction of pathogenic strains. In addition, curcumin treatment has been found to decrease the microbial richness and diversity, with a specific reduction of species found as cancer-related. Several studies reported that curcumin actively reduces intestinal inflammation by modulating different molecular pathways. Thus, it is possible that curcumin, by modulating the homeostasis of the gut–brain axis, could also determine neuroprotective beneficial effects. To address its pharmacological and therapeutic advantages, it is fundamental to consider curcumin interplay with gut microbiota that might pave the way to fill the gap between the low bioavailability and the wide health effects. Curcumin can influence gut microbiota composition, allowing the growth of strains needed to maintain correct host physiologic functions. This is the case of neurodegenerative diseases in which often a gut dysbiosis precedes the onset of the clinical signs. The results summarized in the review suggest that curcumin alone can exert a neuroprotective function by affecting different neuropathological pathways."- Curcumin, Gut Microbiota, and Neuroprotection, Nutrients | December 2019

"Bioavailability of curcumin is not an issue. The therapeutic efficacy of curcumin as evident from numerous clinical trials overpowers the hindrance of low bioavailability. Over 200 clinical studies with curcumin have demonstrated the pronounced protective role of this compound against cardiovascular diseases, inflammatory diseases, metabolic diseases, neurological diseases, skin diseases, liver diseases, various types of cancer, etc. The therapeutic potential of curcumin, as demonstrated by clinical trials has overpowered the myth that poor bioavailability of curcumin poses a problem. Low curcumin bioavailability in certain studies has been addressed by using higher concentrations of curcumin within nontoxic limits. Hence, bioavailability is not a problem in the curcumin-mediated treatment of chronic diseases. Therefore, this golden nutraceutical presents a safe, low-cost and effective treatment modality for different chronic diseases." - Is curcumin bioavailability a problem in humans: lessons from clinical trials, Drug Metabolism Toxicology | September 2019

"In recent years, an exponentially increasing number of studies has indicated that the alterations in the intestinal microbiota are linked with many metabolic diseases, including obesity, diabetes, and chronic liver disease, and the intestinal microbiota is proposed to be a novel potential therapeutic target for these microbiota-associated diseases. Although curcumin has poor systemic bioavailability, after oral administration it is expected to be present in high concentrations in the gastrointestinal tract. Thus, it is rational to infer that curcumin may exert direct regulative effects on the gut microbiota. This may be an important mechanism underlying its therapeutic benefits and could explain the paradox between curcumin’s poor systemic bioavailability and its widely reported pharmacological activities." - Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications, Food & Nutrition Research | August 2019

"The bioavailability of the parent curcumin compound is low, but oral administration of curcumin can still deliver detectable levels of curcumin glucuronide metabolite. Despite the absence of the parent curcumin in the blood/plasma, the antioxidant and epigenetic modulatory effects of curcumin glucuronide can explain the potential overall health beneficial effect of this herbal medicinal product. Thus, it is reasonable to believe that most of the curcumin effects in vivo may be due to local and direct effects rather than systemic effects of this turmeric compound after absorption. This suggests there may be potential health benefits of taking curcumin and challenges negative perceptions on the lack of health benefit or efficacy of taking oral curcumin.  In conclusion, the results of our current study are highly relevant to the over-the-counter use of botanical curcumin in a real-world scenario." - Pharmacokinetics, pharmacodynamics and PKPD modeling of curcumin in regulating antioxidant and epigenetic gene expression in human healthy volunteers, Molecular Pharmaceutics | March 2019

"Effects of Curcumin on Gut Microbiota | Given the low systemic bioavailability of curcumin and its pharmacological therapeutic uses, curcumin might provide benefit by acting on gut microbiota. This impact on the gut microbiota seems to be reasonable and attractable areas of study as no absorption of the parent compound is necessary. It is suspected that curcumin could exert direct regulative effects on the gut microbiota which could explain the paradox between curcumin's poor systemic bioavailability and its widely reported pharmacological effects. There is some indication that curcumin may act as promoting factors of growth, proliferation, or survival for beneficial members of the gut microbiota, and is able to modulate gut microbial composition (i.e., biodiversity). It is suggested that healthy ageing correlates with microbiome diversity. The administration of curcumin significantly shifted the ratio between beneficial and pathogenic microbiota by increasing the abundance of bifidobacteria, lactobacilli, and butyrate-producing bacteria and reducing the loads of Prevotellaceae, Coriobacterales, enterobacteria, and enterococci. Curcumin, through impacts on the microbiota, might positively influence certain organismal functions. By modulating the microbiome, curcumin may reduce some adverse consequences of ageing, and the impact of curcumin on the microbiome seems to be very promising in the context of the modulation of the ageing process. These alterations in gut microbiota could also explain the immune modulation and antihyperlipidemia efficacy of curcumin aside of its anti-inflammatory and anticolonotropic carcinogenicity activity. Effects of Gut Microbiota on Curcumin | The composition of gut microbiota had a profound influence on the biotransformation of curcumin in the colon by various processes mainly by reduction followed by conjugation, which might have a significant impact on the health effects of dietary curcumin, especially in the GI. Data suggests that intestinal bacteria produce a high amount of β-glucuronidase that can elevate the level of free compounds. Microbiota can be responsible for drug metabolism and, by their ability to metabolize curcumin, can regulate its bioavailability." - Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence, Journal of Nutrition and Metabolism | December 2018

"Curcumin has anti-inflammatory, anti-oxidant and anti-proliferative properties established largely by in vitro studies. Accordingly, oral administration of curcumin beneficially modulates many diseases including diabetes, fatty-liver disease, atherosclerosis, arthritis, cancer and neurological disorders such as depression, Alzheimer's or Parkinson's disease. We established curcumin-mediated decrease in the release of gut bacteria-derived lipopolysaccharide (LPS) into circulation by maintaining the integrity of the intestinal barrier function as the mechanism underlying the attenuation of metabolic diseases (diabetes, atherosclerosis, kidney disease) by curcumin supplementation precluding the need for curcumin absorption. In view of the causative role of circulating LPS and resulting chronic inflammation in the development of diseases listed above, this review summarizes the mechanism by which curcumin affects the several layers of the intestinal barrier and, despite negligible absorption, can beneficially modulate these diseases." - Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects, Tissue Barriers | February 2018

"Curcumin was a potent anti-helicobacter pylori agent in vivo and in vitro. Curcumin could partially reverse changes in the diversity of the gut microbiota and could lower the increasing abundance of the genera Anaerotruncus and Helicobacter in the gut of model rats." - Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats, Nutrients | October 2017

"Studies provide evidence that despite low bioavailability, oral curcumin likely mediates its anti-inflammatory (and inflammation-dependent downstream effects) by its local action in the gut. Studies from our laboratory demonstrated the potent effects of oral supplementation with curcumin on the development of glucose intolerance and atherosclerosis. Furthermore, curcumin supplementation attenuated increase in plasma lipopolysaccharide levels by not only increasing the activity of intestinal alkaline phosphatase that detoxifies lipopolysaccharide in the gut lumen but also by improving intestinal barrier function. The data presented herein establishes the intracellular mechanisms by which curcumin improves the intestinal barrier. Apical or luminal exposure to curcumin might underlie its observed effects on improvement of intestinal barrier function by oral administration. The major site of action of curcumin is the intestinal epithelial cells and the intestinal barrier, and by reducing intestinal barrier dysfunction, curcumin modulates chronic inflammatory diseases despite poor bioavailability. Reduced intracellular IL-1β signaling and subsequent reduction in disruption of tight junctions represent the mechanisms underlying the beneficial effects of oral curcumin, despite its poor bioavailability. The causal relationship between curcumin exposure of intestinal epithelial cells and inflammatory bowel diseases is straightforward and is not affected by the issue of poor bioavailability, and oral curcumin is currently being considered as a therapeutic agent for inflammatory bowel disease. Curcumin is expected to not only reduce local inflammation in the gut, but by altering intestinal barrier function it will also reduce systemic inflammation triggered by the release of lipopolysaccharide into circulation." - Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions, American Journal of Physiology Cell Physiology | April 2017

"Metabolites of curcumin are present in high concentrations in the circulation after curcumin consumption. These curcumin metabolites may be responsible for the anti-inflammatory and antioxidant activities that reduce the symptoms of metabolic diseases including osteoarthritis.  Curcumin is detectable in the circulation as the forms of glucuronide and sulfate conjugates in the patients with oral consumption of 8 g/day curcumin for more than 2 months. Thus, curcumin itself can be a therapeutic agent for relieving arthritis." - Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Journal of Medicinal Food |August 2016

"Despite a wide range of pharmacological activities of curcumin reported in the past decades, a paradox remains regarding the pharmacology of curcumin: how curcumin is able to manifest remarkable biological effects under the condition of poor systemic bioavailability. Our novel experimental and theoretical findings suggested that the degradation products should play important roles in executing the biological and pharmacological activities of curcumin. The degradation products of curcumin are actually the main bioactive molecules in executing the biological activities of curcumin.Our finding not only provides a plausible explanation for the seemingly contradictory observations regarding biological activities of curcumin, it is also highly significant for the therapeutic application of this natural product against various human diseases." - How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies, Scientific Reports | February 2016

"The beneficial effect of curcumin on tumorigenesis was associated with the maintenance of a more diverse colonic microbial ecology.These chemopreventive effects appeared unrelated to the reduction of inflammation, but rather to the normalizing effects of curcumin on colonic microbial ecology, thus suggesting that curcumin functions as an effective agent for restoring healthy gut homeostasis and microbial-host relationship. We determined that dietary curcumin maintained high microbial diversity, associated with the expansion of Lactobacillales (represented mainly by genus Lactobacillus). Curcumin contributes to chemoprevention via expansion of the native Lactobacilli in the context of overall increase of colonic microbiome richness. Curcumin has been observed to inhibit bacterial motility and cytotoxicity of Vibrio vulnificus, to arrest Helicobacter pylori growth during infections, as well as inhibit biofilm formation in Pseudomonas aeruginosa. This suggests that the protective effect of 0.5% curcumin diet shifts the microbial composition to be more stationary, which may contribute to a decrease in microbial invasiveness and a decrease in overall disease severity. We demonstrated efficacy of curcumin on inflammation associated colorectal cancer and normalizing effects of colonic microbial ecology. Curcumin may represent a promising approach to chemoprevention in IBD. " - The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention, Inflammatory Bowel Diseases | November 2015

"Curcumin treatment exerted a significant anti-inflammatory effect in H. pylori-infected mucosa, pointing to the promising role of a nutritional approach in the prevention of H. pylori induced deleterious inflammation. Curcumin may be a potential agent for controlling inflammation associated with H. pylori infection. The aim of the present study is to evaluate the anti-inflammatory effect of curcumin using the experimental model of H. pylori chronic infection. Curcumin was effective in reducing the inflammation of the gastric mucosa of H. pylori-infected mice, which was confirmed at the molecular level. At this level the magnitude of the difference in the expression of the inflammatory mediators’ encoding genes between the infected curcumin-treated mice and the infected but non-treated ones strongly supports the powerful anti-inflammatory properties of curcumin. Curcumin acted two ways during protection against H. pylori infection, i.e. by eradicating H. pylori as well as potentially targeting key molecules involved in the H. pylori-induced gastric diseases. This is one of the few studies using both histological and molecular approaches, showing the important anti-inflammatory role of curcumin in the context of chronic H. pylori infection. Taking into account the extensive consumption of polyphenols in the human diet (curcumin and others), our data points to the promising role of a nutritional approach in the control of H. pylori induced deleterious inflammation." - Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model, Nutrients | January 2015

"Curcumin exerts potent effects in reducing metabolic diseases such as diabetes and atherosclerosis by modulating the intestinal barrier function, precluding the need for effective absorption and systemic bioavailability.The significant reduction in glucose intolerance as well as atherosclerosis by oral curcumin demonstrates the importance of targeted improvement in intestinal barrier function as a potential therapeutic strategy. This represents a change in the existing paradigm and places the focus on improving intestinal barrier function rather than direct modulation of gut bacteria itself. In conclusion, the data presented here provide direct evidence for the role of Western diet-induced disruption of intestinal barrier function in the development of metabolic diseases such as diabetes and atherosclerosis. Furthermore, these studies also identify curcumin as an agent effective in restoring the intestinal barrier function by modulating multiple components of this barrier including IAP and paracellular permeability. Future studies will examine the effects of curcumin on other components of the intestinal barrier to further advance our current understanding and to develop curcumin as a dietary supplement to attenuate multiple inflammation-linked diseases." - Oral Supplementation with  Curcumin Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance | Role of Intestinal Permeability and Macrophage Activation, PLoS One | September 2014

"Our experiments show that curcumin supplementation can suppress H. pylori-induced gastric inflammation, as indicated by decreased NF-κB p65 expression in gastric epithelial cells and decreased macromolecular leakage in the gastric microcirculation. Curcumin decreased these parameters, indicating that curcumin could decrease gastric inflammation. Curcumin supplementation may exert its anti-inflammatory effect by reducing macromolecular leakage through the suppression of NF-κB p65 expression in gastric epithelial cells. Hence, curcumin might be a novel therapeutic strategy against gastric inflammation." - Curcumin suppresses gastric NF-κB activation and macromolecular leakage in Helicobacter pylori-infected rats, World Journal of Gastroenterology | August 2010

"Curcumin is biotransformed in the intestinal tract of humans. Curcumin is a large lipophilic molecule that undergoes extensive gastrointestinal and hepatic metabolism after oral dosing. Phase I metabolism is through a reduction reaction forming tetra-hydrocurcumin, hexahydrocurcumin, and hexa-hydrocurcuminol. Phase II metabolism consists of glucouronidation and sulfation by O-conjugation to form curcumin glucuronide and curcumin sulfate. Gut metabolism contributes substantially to the overall metabolite yield generated from curcumin in vivo. The pharmacological implications of the intestinal metabolism of curcumin should be taken into account in the design of future chemoprevention trials of this dietary constituent." - Metabolism of the Cancer Chemopreventive Agent Curcumin in Human and Rat Intestine, Cancer Epidemiology, Biomarkers & Prevention | January 2002

n most studies Curcumin 95% has been delivered orally whether the subject is human or animals. This orally delivered Curcumin 95% extract showed antioxidant, anti-inflammatory, antidiabetic, and anticancer beneficial effects. Oral curcumin efficacy in vivo has been shown in models for many conditions with oxidative damage and inflammation, including many types of cancer, diabetes, atherosclerosis, arthritis, stroke, peripheral neuropathy, inflammatory bowel, and brain trauma. Curcumin is fat-soluble, so when combined with healthy fats and oils, the body can absorb it better because curcumin is directly absorbed into the bloodstream through the lymphatic system thereby in part bypassing the liver. A traditional method of dissolving curcumin in fat is likely an effective method to improve absorption. You can also ensure you are absorbing the maximum amount by consuming curcumin with fats from meat, fish, dairy, olive oil, coconut oil and others. 

"In vitro and in vivo studies have confirmed the activity of curcumin in biological system by either detecting curcumin or its bio-transformed metabolites in plasma, peripheral organs and brain." - bioRxiv

"Clinical trials have shown that orally delivered curcumin inhibited inflammatory molecules." - AAPS Journal

"Levels of curcumin and its metabolites in plasma, urine, and feces were analyzed by high-pressure liquid chromatography and mass spectrometry.  A daily dose of 3.6g curcumin engendered 62% and 57% decreases in inducible PGE2 production in blood samples taken 1 hour after dose on days 1 and 29, respectively, of treatment compared with levels observed immediately predose (P < 0.05). A daily oral dose of 3.6g of curcumin is advocated for Phase II evaluation in the prevention or treatment of cancers outside the gastrointestinal tract. PGE2 production in blood and target tissue may indicate biological activity. Levels of curcumin and its metabolites in the urine can be used to assess general compliance." - Clinical Cancer Research

"Oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients." - Radiation Research

"Curcumin mixed with the diet achieves drug levels in the colon and liver sufficient to explain the pharmacological activities observed and suggest that this mode of administration may be preferable for the chemoprevention of colon cancer. The colon mucosal level of curcumin after 14 days feeding observed in this study, 1.8 μmol/g, is more than 300-fold higher than the minimal concentration shown to be active in vitro. This result demonstrates that dietary administration of curcumin can produce pharmacologically relevant drug concentrations in colon mucosa. Our results therefore intimate that dietary curcumin at doses considerably lower than those used here might yield pharmacologically efficacious levels in the colon mucosa and perhaps also in the liver. The M1G-lowering effect of curcumin provides a tentative rationale for the regular use of dietary curcumin in the protection of the colon mucosa against oxidative damage, perhaps in premalignant conditions such as ulcerative colitis. Dietary administration of curcumin to rats produces pharmacologically active levels of unmetabolized curcumin in the colon mucosa and liver, capable of decreasing M1G levels and elevating GST activity. These effects may contribute to cancer chemoprevention. The results also suggest that dietary admixture may be the preferable mode of administration for curcumin in the chemoprevention of colon cancer. The chemopreventive efficacy of oral curcumin in the colorectum and the liver merits clinical evaluation." - Effects of Dietary Curcumin on Glutathione S-Transferase and Malondialdehyde-DNA Adducts in Rat Liver and Colon Mucosa, Experimental Therapeutics, Preclinical Pharmacology

"Oral administration of 90 mg of curcumin or the placebo 2 hours before exercise and immediately after exercise. Curcumin supplementation attenuated exercise-induced oxidative stress by increasing blood antioxidant capacity." - Int J Sports Med.

"In animal oral administration, Curcumin inhibited lung cancer, skin cancer, head and neck cancer, oral cancer, hepatocellular carcinoma, mammary tumors, lymphomas, leukemias, and familial adenomatous polyposis." - Cancer Res Treat.

"Oral treatment of curcumin found to effective in diabetic condtion. It attenuated high fat diet-induced glucose intolerance and elevations of oxidative stress in the skeletal muscle." - World J Diabetes

"Curcumin was effective both orally and topically. These results show that curcumin enhanced wound repair in diabetic impaired healing, and could be developed as a pharmacological agent in such clinical settings." - Wound Repair Regen

"Our findings indicate that curcumin is a potent anti-inflammatory agent that prevents the release of TNFα and protects against the pulmonary and cardiovascular effects of DEP." - PLoS One

"In a human clinical trial, 3.6 g of Curcumin via oral route was found to produce a plasma curcumin level of 11.1 nmol/L after an hour of dosing." - Clinical Cancer Research

"The average peak serum concentrations after taking 4,000 mg, 6,000 mg and 8,000 mg of curcumin were 0.51 microM, 0.63 microM and 1.77 microM, respectively." - Phase I Clinical Trial of Curcumin, Anticancer Research

"Traces of curcumin were detected in the plasma. Its concentration in the small intestinal mucosa, between 39 and 240 nmol/g of tissue, reflects differences in dietary concentration...The comparison of dose, resulting curcumin levels in the intestinal tract, and chemopreventive potency suggests tentatively that a daily dose of 1.6 g of curcumin is required for efficacy in humans." - Journal Cancer Epidemiol Biomarkers

"The concentrations of curcumin in normal and malignant colorectal tissue of patients receiving 3,600 mg of curcumin were 12.7 +/- 5.7 and 7.7 +/- 1.8 nmol/g, respectively...The results suggest that a daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut." - Cancer Epidemiol Biomarkers

"One hour after administration, the levels of curcumin in the intestines, spleen, liver, and kidneys were 177.04, 26.06, 26.90, and 7.51 microg/g, respectively." - Journal Drug Metab Dispos.

"Bromelain (pineapple extract) substantially promotes the absorption of curcumin enhancing its bioavailability, and making this a perfect combination of immune-boosting nutraceuticals with synergistic anti-inflammatory and anticoagulant actions." - Metabolism

"Buttermilk could be used as a carrier for curcuminoids especially if delivered with food...The most important and practical finding from the bioaccessibility data is that the incorporation of powdered curcuminoids with buttermilk results in a 15-fold increase in bioaccessibility of curcuminoids." - Food Chemistry

"Curcumin was found in plasma (16.1 ng/mL), urine (2.0 ng/mL), intestinal mucosa (1.4 mg/g), liver (3,671.8 ng/g), kidney (206.8 ng/g), and heart (807.6 ng/g)." - Journal Agric Food Chem.

"Curcuminoids were detectable in plasma samples, urine samples, and in the colonic mucosa of all 23 biopsied participants. Mean tissue levels were 48.4 μg/g (127.8 nmol/g) of parent curcuminoids. The major conjugate, curcumin glucuronide, was detectable in 29 of 35 biopsies. High levels of topical curcumin persisted in the mucosa for up to 40 hours postadministration. In summary, pharmacologically active levels of curcumin were recovered from colonic mucosa. The regimen used here seems safe, and patients support its use in long-term trials." - Cancer Prev Res.

"After oral administration of 400 mg Curcumin to rats, about 60% of the dose was absorbed." - Journal Toxicology

"Tissue distribution of Curcumin using tritium-labeled drug. They found that radioactivity was detectable in blood, liver, and kidney following doses of 400, 80, or 10 mg of [3H] curcumin. With 400 mg, considerable amount of radio labeled products were present in tissues 12 days after dosing. The percentage of curcumin absorbed (60-66% of the given dose) remained constant." - Journal Toxicology

Curcumin rescues breast cells
International Journal of Oncology, December 2019
Breast cancer is the most prevalent type of cancer among women worldwide and it is characterized by a high morbidity. Curcumin is a naturally occurring compound derived from the rhizome of Curcuma longa and is known to have antioxidant and anticarcinogenic properties. Curcumin also acted upon the miRNA as a regulator of genes implicated in EMT and upon Rho‑A as well, affecting the migration and invasion of the cells. This occurred independently of their estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) receptors in the non‑malignant MCF‑10F and malignant MDA‑MB‑231 breast cell lines, which are both negative for such receptors.

Turmeric and Inflammatory Diseases: An Overview of Clinical Evidence
Department of Traditional Pharmacy, December 2019
Turmeric (Curcuma longa L.) and its major ingredients, curcuminoids, are the well-known natural products used for the management of several inflammatory conditions including inflammatory bowel diseases, irritable bowel syndrome, osteoarthritis, rheumatoid arthritis, renal diseases, oral lichen planus, gingivitis and periodontitis, radiation-induced oral mucositis and dermatitis, psoriasis, and respiratory problems. Main inflammatory markers in chronic inflammation include C-reactive protein, tumor necrosis factor-α, and different interleukins which are assessed in the clinical trials. Turmeric and curcumin have demonstrated significant effect in some clinical trials.

Effect of Curcumin on the Diversity of Gut Microbiota
Department of Analytical and Food Chemistry, December 2019
Curcumin, the main active component of turmeric (Curcuma longa), is widely used as a flavoring and coloring agent in food, and also exhibits multiple pharmacological activities. It has been traditionally used in Asian countries as a medical herb for several pathologies due to its anti-inflammatory, antioxidant, antimicrobial, antimutagenic, and anticancer properties. Further, curcumin may potentially complement the conventional treatment of insulin resistant conditions, including obesity, pre-diabetes, metabolic syndrome, and type II diabetes. Recently, its potential utility in Auto-Immune Deficiency Syndrome (AIDS) had been demonstrated.

Antibacterial and Anticancer Activities of Turmeric and its Active Ingredient Curcumin
Department of Biotechnology, Institute of Biosciences and Biotechnology, December 2019
Turmeric (Curcuma longa) contains curcuminoids, and various sesquiterpenes which contributes towards a wide array of biological activities, e.g. anti-inflammatory, wound healing, anticancer, and antibacterial activities. Curcuminoids and sesquiterpenes are the main constituents of turmeric, for which a plethora of molecular targets, and pharmacological activities have been reported. The most studied activity of the curcuminoids present in turmeric in the recent year is the anticarcinogenic activity. Experiments have shown that curcuminoids modify the gene expression of cancer related markers. Curcumin has the potential to regulate genes related to cell division, cell cycle regulation, and apoptosis. The anticarcinogenic activity of turmeric has been studied in case of lung, breast, prostate, ovarian, colorectal cancers, leukemia, and multiple myelomas. Turmeric significantly inhibits benzopyrene induced forestomach papillomas. Dietary turmeric, along with catechin, is a chemoprotective agent. Besides anticarcinogenic effect, the antibacterial activity of turmeric against various bacteria, such as Streptococcus aureus, Trichophyton gypseum, Salmonella paratyphi, and Mycobacterium tuberculosis has also been explored. The active ingredients of turmeric can be used as lead compounds to design potential drugs for the treatment of different types of bacterial diseases and cancers.

Curcumin, Gut Microbiota, and Neuroprotection
Nutrients, December 2019
Curcumin, a nontoxic, naturally occurring polyphenol, has been recently proposed for the management of neurodegenerative and neurological diseases. It is possible that curcumin could exert direct regulative effects primarily in the gastrointestinal tract, where high concentrations of curcumin are present after oral administration. Indeed, a new working hypothesis that could explain the neuroprotective role of curcumin despite its limited availability is that curcumin acts indirectly on the central nervous system by influencing the “microbiota–gut–brain axis”, a complex bidirectional system in which the microbiome and its composition represent a factor which preserves and determines brain “health”. Interestingly, curcumin and its metabolites might provide benefit by restoring dysbiosis of gut microbiome. Conversely, curcumin is subject to bacterial enzymatic modifications, forming pharmacologically more active metabolites than curcumin. These mutual interactions allow to keep proper individual physiologic functions and play a key role in neuroprotection. 

Can curcumin reduce cardiovascular risk factors?
Examine.com, December 2019
 Curcumin is thought to have multiple possible health benefits. This meta-analysis zeros in on its effects on cardiovascular risk factors. Cardiovascular disease (CVD) is the number one cause of death in the U.S., but some of the risk factors for CVD are modifiable. One of the most well-known risk factors are serum lipid levels, in particular LDL cholesterol and triglycerides.  Researchers and healthcare practitioners alike are therefore interested in the potential properties of turmeric, and more specifically its active ingredient curcumin, for possible anti-inflammatory and lipid-lowering effects. Curcumin has long been touted[2] as having medicinal benefits, and the safety of curcumin, even at high doses[3], has been consistently demonstrated. Curcumin is a polyphenol shown in preclinical and clinical research to have anti-inflammatory[4] properties and its effects have been studied in people with numerous disease states[5][6][7]. In studies examining the effects of supplemental curcumin on participants with cancer, those receiving supplementation showed reduced levels of numerous proinflammatory biomarkers.

Turmeric can help treat oral cancers
u4uvoice.com, December 2019
HPV is a virus that promotes the development of cervical and oral cancer. There is no cure, but the new findings suggest that curcumin may offer a means of future control. Mishra’s research group first noted the effect of curcumin on HPV and cervical cancer cells in 2005. The antioxidant slowed the expression of HPV, suggesting that curcumin could control the extent of HPV infection. “Since HPV-related oral cancer cases are on the rise, we tested the same hypothesis on oral cancer,” Mishra explained. “They turned out to be some very interesting findings.” The new research indicates that curcumin turns down the expression of HPV in infected oral cancer cells by downregulating the levels of cellular transcription factors AP-1 and NF-kB.

How to live longer: Five diet tips to prevent disease and boost life expectancy
Express, December 2019
Curcumin, found in turmeric, is believed to give the yellow spice its health properties, and studies have linked it to improved brain function, lower risk of heart disease and even cancer prevention.  Turmeric is renowned for its anti-inflammatory properties. Curcumin has also been linked to an increased lifespan in both insects and mice.

Curcumin May Help Prevent or Combat Stomach Cancer, Study Finds
Yoga Esoteric, December 2019
Curcumin – derived from the turmeric plant (Curcuma longa) – has been used to impart color and flavor to food in many areas of the world. But long ago, scientists discovered that the bright, yellow powder can also help prevent and fight stomach cancer. In a study conducted by researchers at the Federal University of São Paulo (UNIFESP) and the Federal University of Pará (UFPA) in Brazil, the possible therapeutic effects of the pigment were identified. The study was part of a Thematic Project supported by São Paulo Research Foundation, or FAPESP. The findings have been published in the journal Epigenomics. “We undertook a vast review of the scientific literature on all nutrients and bioactive compounds with the potential to prevent or treat stomach cancer and found that curcumin is one of them,” said Danielle Queiroz Calcagno, first author of the study and a professor at UFPA.

The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease
Phytotherapy Research, December 2019
Several clinical trials have examined the effects of curcumin supplementation on anthropometric variables in NAFLD patients with inconclusive results. Curcumin supplementation significantly reduced BMI. These results suggest that curcumin supplementation might have a positive effect on visceral fat and abdominal obesity that have been associated with NAFLD.

Herbs to control hypertension and diabetes
Times of India, December 2019
Turmeric has a compound known as curcumin in it, which has shown to control blood sugar levels as well as prevent the onset of diabetes. In a nine-month-long study, 240 participants who had pre-diabetes were made to have curcumin capsules every day. These people did not develop diabetes by the end of nine months.

Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation
Nutrition & Metabolism, December 2019
Curcumin is a natural polyphenolic compound present in turmeric and possesses antiinflammatory, antioxidant and hepatoprotective properties. In recent animal studies, curcumin has been shown to have a protective effects on the liver against fat accumulation induced by a high-fat diet. The administration of curcumin significantly prevented HFD-induced body weight gain and reduced liver weight. Curcumin attenuated hepatic steatosis along with improved serum lipid profile. Moreover, curcumin up-regulated the expression of intestinal tight junction protein zonula occluden-1 and occludin, which further improved gut barrier dysfunction and reduced circulating lipopolysaccharide levels. Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-κB (NF-κB) in the liver. In addition, the mRNA expression of hepatic tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) as well as the plasma levels of TNF-α and IL-1β were also lowered by curcumin treatment. These results indicated that curcumin protects against HFD-induced hepatic steatosis by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation. The ability of curcumin to inhibit hepatic steatosis portrayed its potential as effective dietry intervention for non-alcoholic fatty liver disease (NAFLD) prevention.

Foods that Can Help Students Regulate Blood Sugar and Prevent Diabetes
University Herald, December 2019
Turmeric -has the most important content called curcumin. It can help reduce blood sugar levels and inflammation while protecting against heart and kidney disease. Curcumin appears to benefit kidney health in diabetics, thus it is important to also include this on your diet because diabetes is one causes of kidney diseases.

Want to Have a Slim Body? These Kitchen Ingredients Can Help You
India.com, December 2019
Containing a significant compound called curcumin, turmeric can prevent you from becoming obese. It can do so by increasing your body’s metabolism rate. Also, it helps in fighting against debilitating conditions like cancer and Alzheimer’s disease.

Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease
International Journal of Molecular Sciences, December 2019
Curcumin has several therapeutic properties that include anti-excitotoxic, anti-oxidant, anti-apoptotic, anti-hyperhomocysteinemia and anti-inflammatory effects, mitochondrial protection, as well as increasing neuronal lifespan and promoting neurogenesis. In addition, curcumin also exerts anti-amyloidogenic effects and affects the brain’s tau protein.  Accumulating evidence has clearly shown the role of the neuroprotective and neurological/cognitive enhancement effects of curcumin after brain ischemia-reperfusion injury with the phenotype of Alzheimer’s disease. Based on the data presented, it appears that curcumin has its own effective therapeutic potential through anti-amyloid, anti-tau protein hyperphosphorylation, anti-hyperhomocysteinemia, anti-oxidant, anti-inflammatory, and anti-apoptotic effects which clearly indicates that curcumin can be used as a neuroprotective substance not only in ischemic neurodegeneration but also in a neurodegenerative disease similar to Alzheimer’s disease as a response to brain ischemia associated with hyperhomocysteinemia. The available data show that curcumin induces neuroprotection and neurogenesis and may be a new therapeutic agent for both regenerative medicine and for the treatment of neurodegenerative disorders such as neurodegeneration after brain ischemia with the phenotype of Alzheimer’s disease. Therefore, curcumin may be a promising supplementary agent against brain ischemia-reperfusion injury in the future. Indeed, there is a rational scientific basis for the use of curcumin for the prophylaxis and treatment of ischemic neurodegeneration.These results suggest that curcumin may be able to serve as a potential preventive and therapeutic agent in neurodegenerative brain disorders.

Foods for maintaining healthy arteries
The Saxon, December 2019
Curcumin is an anti-inflammatory substance. This substance does not allow the arteries to become hard and accumulate harmful plaque. Turmeric is also rich in vitamin B6, which prevents damage of blood vessels and prevents plaque accumulation. And yet, this spice reduces the level of malicious lipids and reduce the oxidation of cholesterol.

Protection of Curcumin against Streptozocin-Induced Pancreatic Cell Destruction in T2D Rats
Planta Medica, December 2019
As a kind of traditional Chinese medicine extract, curcumin has been proven to be effective in inhibiting inflammation and apoptosis in pancreatic islet β cells in the streptozotocin-induced diabetes mellitus rat model, although the underlying mechanism has not yet been clarified.  Curcumin administration significantly decreased fasting blood glucose and promoted recovery of pancreas function in type 2 diabetes rats. In curcumin-treated rats, the pancreatic tissue destruction and apoptosis index were reduced. The expression of IL-1β, IL-6, TNF-α, caspase-3, Bax, and malondialdehyde were significantly reduced, and Bcl-2, superoxide dismutase 2, and glutathione peroxidase were significantly increased. Curcumin inhibited the expression of phosphorylated JNK and NF-κB proteins to block the RAGE/JNK/NF-κB signaling pathway. In conclusion, these results indicate that curcumin blocks the phosphorylation of JNK and NF-κB protein to inhibit this signaling pathway, thereby further inhibiting inflammation and apoptosis in pancreatic islet β cells. Curcumin has potential value for the treatment of diabetes.

Potential therapeutic effects of curcumin and niacin in rotenone-induced Parkinson’s disease mice model
Molecular and Cellular Biochemistry, December 2019
Treatment with curcumin, niacin, adenosine A2AR antagonist; ZM241385 and their combination enhanced the animals’ behavior and restored all the selected parameters with variable degrees of improvement. The brain histopathological features of hippocampal and substantia nigra regions confirmed our results. In conclusion, the combination of curcumin, niacin and ZM241385 recorded the most potent treatment effect in Parkinsonism mice followed by ZM241385, as a single treatment. ZM241385 succeeded to antagonize adenosine A2A receptor by diminishing its gene expression and ameliorating all biochemical parameters under investigation. The newly investigated agent; ZM241385 has almost the same pattern of improvement as the classical drug; Sinemet®. This could shed the light to the need of detailed studies on ZM241385 for its possible role as a promising treatment against PD. Additionally, food supplements such as curcumin and niacin were effective in Parkinson’s disease eradication.

The Protective Effect of Curcumin Against Cisplatin-Induced Nephrotoxicity Experimentally in Rats
Archives of Pharmacal Research, December 2019
Curcumin has renal protective properties against kidney damage. The results clarified the strong protective effect of curcumin on cisplatin induced nephrotoxicity in rats at the molecular level. Curcumin is known for its high oxygen-radical scavenging and quenching power. It is a scavenger of free oxygen radicals and stimulates the activity of additional antioxidant molecules such as superoxide dismutase, catalase, and glutathione peroxidase. It is a bifunctional antioxidant because of its ability to react directly with reactive species and to induce an up regulation of various cytoprotective and antioxidant proteins. Curcumin can react with ROS through its phenolic and methoxy groups and it is thought to be one of the mechanisms through which it can protect the renal epithelial from ROS activity. Curcumin can indirectly induce the expression of cytoprotective proteins such as superoxide dismutase. Furthermore, it has been reported that curcumin can increase the synthesis and concentration of GSH. In summary, this study demonstrated that curcumin can protect against nephrotoxic effects of cisplatin in rats. The protective effect of curcumin occurred through the up regulation of antioxidants and suppression of oxidative stress markers. Curcumin is a promising therapy for management of kidney nephrotoxicity.

Spice Stops Cancer, Study Finds
The Institute for Natural Healing, November 2019
 UCLA researchers found that curcumin activates cancer-fighting enzymes in patients with head and neck cancers. A 2013 study at the University of North Texas Health Science Center found that curcumin suppresses pancreatic cancer tumors. A 2006 study published in the journal Neuroscience Letters found that curcumin induces cell death in glioblastoma (brain cancer) cells. A Chinese study showed that curcumin makes stomach cancer less resistant to chemotherapy. A study at MD Anderson Cancer Center showed that curcumin slowed the progression of multiple myeloma (blood cancer). With all this evidence (and this is by no means a complete list) you may be wondering why curcumin isn’t widely prescribed for the prevention and treatment of cancer. People in India get curcumin by eating turmeric at almost every meal. Most Americans are not willing to do this. That’s why, for most of us, curcumin supplements are the best option for cancer prevention. Curcumin is safe for just about everyone. Fat increases bioavailability, taking curcumin with a meal that includes fat improves absorption.

Curcumin: hopeful treatment of hemophilic arthropathy via inhibition of inflammation and angiogenesis
Expert Review of Hematology, November 2019
Curcumin is known for its strong anti-inflammatory and anti-angiogenic potentials. This agent is able to inhibit the mentioned inflammatory and angiogenic factors such as IL-1, IL-6, TNF-α, VEGF, MMPs, and HIF-1α. Also, as well as anti-angiogenic and anti-inflammatory activity, curcumin has a strong antioxidant potential and can decrease oxidative stress.Expert opinion: It seems that curcumin could be considered as a possible agent for the treatment of HA through inhibition of inflammation, oxidative stress, and angiogenesis.

Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta‐analysis of controlled trials
Journal of Gastroenterology and Hepatology, November 2019
Curcumin, as an adjuvant treatment of mesalamine, was proved to be effective and safe in ulcerative colitis. Better efficacy can be achieved with suitable dose, delivery way, formation, and intervention time, which needs further study to verify.

How To Treat Joint Problems: This Anti-Inflammatory Spice May Be The Solution
IBTimes, November 2019
Another benefit that turmeric is starting to be known for is its ability to reduced inflammation, particularly in swollen joints. Research shows that a substance called curcumin, which the turmeric roots are abundant with, provides a positive impact on the body’s inflammatory pathways. Curcumin gives turmeric its potent anti-inflammatory properties. Researchers revealed the many benefits of turmeric supplements like minimizing inflammation associated with rheumatoid arthritis and inflammatory bowel disease or IBS. It has also been proven very effective in the treatment of abdominal pain for those who are suffering from IBS. While the study on turmeric has been focused on its ability to reduce inflammation, researchers say it is also a good source of strong antioxidants and minerals. Turmeric root extracts have been observed to protect the cells in the body and counter the damage caused by free radicals. Turmeric has also been found to be rich in phosphorus, potassium, and manganese. These minerals play a vital role in the health of the heart, muscles, and bones. Muswell recommends adding turmeric to a regular diet to help increase the intake of minerals and antioxidants that the body needs.

Curcumin May Improve Adipocyte Health, Adiponectin Metabolism
Endocrinologyadvisor, November 2019
Curcumin supplementation moderately increases circulating adiponectin, which could have beneficial effects on pathways related to adipocyte health and adiponectin metabolism, according to study results published in Diabetology & Metabolic Syndrome. The therapeutic benefits of curcumin, a bioactive yellow-orange pigment found in turmeric, have been shown in metabolic diseases. The pooled effect sizes showed that curcumin supplementation significantly increased adiponectin concentrations vs placebo.

Best supplements for joints: The exotic spice proven to have anti-inflammatory properties
Express.co.uk, November 2019
The most researched beneficial substance found in the turmeric root is curcumin. Yasmin explained: "Turmeric and curcumin, can impact inflammatory pathways in the body, giving it it’s powerful anti-inflammatory properties. Research has shown benefits of turmeric supplements reducing inflammation with inflammatory bowel disease (IBD), rheumatoid arthritis and reducing abdominal pain in IBS sufferers. Although much of the research focuses on reducing inflammation in these more diagnosable conditions, we can benefit from anti-inflammatory actions that turmeric has to offer to counterbalance inflammation coming from a more westernised style diet."

Curcumin lessens unpredictable chronic mild stress-induced depression and memory deficits
Pakistan Journal of Pharmaceutical Science, November 2019
Unpredictable chronic mild stress (UCMS) model is the most established method to study neurobiological mechanisms of depression. This work was intended to explore the efficacy of curcumin to revert the UCMS-induced oxidative burden and associated depression as well as potential of curcumin as an acetyl cholinesterase (AchE) inhibitor.  Findings showed that curcumin supplementation significantly attenuated the UCMS-induced depression and anxiety like symptoms, decreased the load of UCMS propagated oxidative stress by improving antioxidant enzymes activities. Curcumin also improved the memory function and exhibited inhibitory effect on AchE activity. In conclusion it can be suggested that supplementation of curcumin in daily life can help in combating the stress-induced depression and ever increasing load of oxidative stress. Study also highlights the anti-acetylcholinesterase potential of curcumin which may be responsible for improved memory function following UCMS.

Curcumin Ameliorates Dermatitis
Inflammation Journal, November 2019
Curcumin, extracted from the roots of Curcuma longa, has been used as an anti-inflammatory agent since the time of Ayurveda.  Overall, our findings demonstrate that curcumin treatment blunts the development of AD as well as associated atopic march in experimental mice.

Curcumin protects sodium nitrite-induced hepatotoxicity
Toxicology Reports, November 2019
Pre-treatment with curcumin significantly (P < 0.05) prevented these alterations by adjusting the lipid profile, liver function markers, and C-reactive proteins and abrogating the elevated markers of oxidative stress as supported by the liver histology. This suggests that dietary consumption of curcumin is beneficial against NaNO2 induced oxidative stress of the liver via its antioxidant potential.

Fight Diabetes With Curcumin
Only My Health, November 2019
Curcumin reduced blood sugar and cholesterol levels by reducing saturated fats found primarily in dairy products, red meat and helps eliminate trans fats. Curcumin prevents Liver Fat accumulation, fats accumulated due to alcohol consumption, reducing hepatocellular inflammation. Curcumin is known to control white blood cells, which also lead to inflammation in the body. Curcumin in all its benefits helps in treating inflammation in the body and further reduce the complications, as inflammation is a significant reason for diabetes. Curcumin is also essential in reducing resistance to insulin. This ingredient also helps insulin get into cells for preventing diabetes. In a study of 240 people, the only thing that saved people from diabetes and its symptoms was curcumin. Around 16% of the 116 people on placebo (inactive treatment) had Type 2 diabetes in nine months. In simpler terms, curcumin is an “antioxidant.” It is a known fact that oxygen is an essential component required to live but also leads to corrosion. Just like iron rusts in the open air, the reactive oxygen species also can lead to rusting of blood vessels and other organs. This study also pointed out towards a connection between curcumin and a protection layer from oxidation. Curcumin suppresses the Inflammatory process by inhibiting various cytokines and interleukins responsible for it.

Curcumin for arthritis
Medical Daily, November 2019
A new study shows that curcumin, a naturally occurring substance in the spice turmeric, could help improve the conditions of people with knee osteoarthritis. Researchers analyzed the effects of curcumin in 139 people. The participants reported moderately severe symptoms of osteoarthritis and took treatments with a nonsteroidal anti-inflammatory drug (NSAID). Researchers divided the patients into groups that took either diclofenac or curcumin every day for a month. Result showed that both treatments provided health benefits. Researchers said 94 percent of the group that received curcumin and 97 percent of those under diclofenac reported up to 50 percent improvement in their arthritis symptoms. Curcumin causes less side effects. Some people who took diclofenac required treatment for stomach problems after the study, while none of the participants taking curcumin experienced similar unwanted effects.

The Effects of two Weeks Exhaustive swimming and Curcumin Supplementation on Liver Damage
Department of Exercise Physiology, November 2019
Curcumin is an active ingredient in turmeric, which is used as herbal medicine for the treatment of certain diseases. The reduction of liver damage markers in this study suggests that exercise and curcumin consumption may, through protective effects, improve the negative effects of alcohol on the liver, and prevent alcohol induced liver disease.

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats
Pharmacology and Toxicology, November 2019
Concurrent administration of curcumin at the oral doses of 50 and 100 mg/kg with ACR significantly protected the rats from ACR-induced weigh loss and motor function deficits, and improved the pathological alterations in the ACR-intoxicated brains. Curcumin treatment especially at a high dose enhanced the TERT mRNA expression level and increased the number of TERT-positive nerve cells in cortex tissues of ACR intoxicated rats. The levels of MDA, TNF-α and IL-1β in the cerebral homogenates were reduced, the contents of GSH as well as the activities of SOD and GSH-Px were increased by curcumin treatment, compared to ACR control group. Conclusions: These data suggested the anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on ACR-induced neurotoxicity in rats. And maintaining TERT-related anti-apoptotic function might be one mechanism underlying the protective effect of curcumin on ACR-intoxicated brains.

Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment
Nutrients, October 2019
Among these medicinal plants, curcumin is gaining a growing interest in the scientific community. Curcumin is a bioactive molecule present in the rhizome of the Curcuma longa plant, also known as turmeric. Curcumin has different pharmacological and biological effects that have been described by both in vitro and in vivo studies, and include antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, anti-neoplastic, hepato-protective, immunomodulatory, hypoglycaemic and anti-rheumatic effects. In animal models, curcumin extract delays diabetes development, improves β-cell functions, prevents β-cell death, and decreases insulin resistance. The present review focuses on pre-clinical and clinical trials on curcumin supplementation in T2DM and discusses the peculiar mechanisms by which curcumin might ameliorate diabetes management.

Therapeutic Effects of Curcumin—From Traditional Past to Present and Future Clinical Applications
International Journal of Molecular Sciences, October 2019
The excellent results of the scientific projects that underlie the five original papers give reason to hope that curcumin will be part of novel treatment strategies in the near future—either as monotherapy or in combination with other drugs or therapeutic applications.

Curcumin May Help Prevent Or Combat Stomach Cancer, Study Finds
Waking Times, October 2019
Curcumin — derived from the turmeric plant (Curcuma longa) — has been used to impart color and flavor to food in many areas of the world. But long ago, scientists discovered that the bright, yellow powder can also help prevent and fight stomach cancer. “We undertook a vast review of the scientific literature on all nutrients and bioactive compounds with the potential to prevent or treat stomach cancer and found that curcumin is one of them,” said Danielle Queiroz Calcagno, first author of the study and a professor at UFPA.

Curcumin-Induced Autophagy Augments Its Antitumor Effect against A172 Human Glioblastoma Cells
Biomolecules & Therapeutics, October 2019
Curcumin, from Curcuma longa, is an effective antitumor agent. Although the same proteins control both autophagy and cell death, the molecular connections between them are complicated and autophagy may promote or inhibit cell death. We investigated whether curcumin affects autophagy, which regulates curcumin-mediated tumor cell death in A172 human glioblastoma cells. When A172 cells were incubated with 10 μM curcumin, autophagy increased in a time-dependent manner. Curcumin-induced cell death was reduced by co-incubation with the autophagy inhibitors 3-methyladenine (3-MA), hydroxychloroquine (HCQ), and LY294002. Curcumin-induced cell death was also inhibited by co-incubation with rapamycin, an autophagy inducer. When cells were incubated under serum-deprived medium, LC3-II amount was increased but the basal level of cell viability was reduced, leading to the inhibition of curcumin-induced cell death. Cell death was decreased by inhibiting curcumin-induced autophagy using small interference RNA (siRNA) of Atg5 or Beclin1. Therefore, curcumin-mediated tumor cell death is promoted by curcumin-induced autophagy, but not by an increase in the basal level of autophagy in rapamycin-treated or serum-deprived conditions. This suggests that the antitumor effects of curcumin are influenced differently by curcumin-induced autophagy and the prerequisite basal level of autophagy in cancer cells.

The Role of Curcumin in the Modulation of Ageing
International Journal of Molecular Sciences, October 2019
Curcumin causes the elongation of the lifespan of model organisms, alleviates ageing symptoms and postpones the progression of age-related diseases in which cellular senescence is directly involved. Curcumin is a promising anti-ageing compound which is easily available and easy to apply in the diet, as well as being safe and not expensive. Curcumin is a widely studied nutraceutical, belonging to polyphenols, acquired from the rhizome of a plant Curcuma longa (turmeric), a member of the ginger family. The highest achieved serum level of curcumin was about 1.77 µM, 1 h after administration, during the oral ingestion of 8 g of curcumin per day, or even 3.6 µM if such a dose was consumed for 3 months. Data collected by curcumin researchers showed a large number of beneficial activities for this compound. They mostly concern its anti-cancer activity, but, for several years, the amount of data showing curcumin’s role in the modulation of ageing has been intensively growing

Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
Arthritis Research & Therapy, October 2019
Curcumin administration effectively alleviated MSU-induced inflammation by suppressing the degradation of IκBα, the activation NF-κB signaling pathway, the damage of mitochondria, and the activity of NLRP3 inflammasome. Our results provide a new strategy in which curcumin therapy may be helpful in the prevention of acute episodes of gout.

Turmeric Can Support Your Active Lifestyle
Mind Body Green, October 2019
The anti-inflammatory benefits of turmeric and its compounds called curcuminoids (specifically curcumin) make the herb work similarly to the anti-inflammatory painkillers in our medicine cabinets. Studies have shown promising results in turmeric's ability to help manage muscular and joint pain after strenuous exercise.

The Health Benefits of Turmeric a Nutritionist Wants You to Know
Yahoo News, October 2019
Several studies have found that the key protective compound in turmeric, called curcumin, reduces inflammation, and its effects are on par with some anti-inflammatory medications. Curcumin also acts as an antioxidant, to counter damaging compounds called free radicals, and fight what’s known as oxidative stress. In a nutshell, oxidative stress occurs when there is an imbalance between the production of cell-damaging free radicals and the body's ability to counter their harmful effects. Because of curcumin's anti-inflammatory and antioxidant benefits, turmeric has health benefits for skin, preventing or helping to repair visible signs of aging. Curcumin has also been shown to increase levels of neurotrophic factor (BDNF) in the brain. That’s crucial, because BDNF acts as a type of growth hormone that protects the brain from age-related decline or damage. Low BDNF levels are tied to depression, as well as Alzheimer’s.

Turmeric – the Golden Spice and wonder drug
Deccan Herald, October 2019
Another research finding says: The results obtained from the present review revealed that curcumin can be effective in various types of oxidative associated liver disorders. This potentiality attributes to curcumin effects on hepatotoxicity, non-alcoholic steatohepatitis, alcoholic liver disease, liver fibrosis and cirrhosis as well as hepatic injury. Experimental evidence indicates that curcumin exhibits its preventive and curative effect against oxidative associated liver diseases.

Pre-administration of curcumin prevents hyperhomocysteinemia in ethanol-induced gastric ulcer
World Journal of Pharmacy and Pharmaceutical Sciences, October 2019
Curcumin is a prototype natural product that has been widely recognized as an antioxidant and anti-inflammatory agent. In this study, we aimed to evaluate the potentialrole of curcumin supplementation in attenuating the aggressive effect of alcohol in experimental induced gastric ulcer. Whereas, pre-treatment of curcumin prevented the hyperhomocysteinemia and the elevation of TNF-α resultingin a depletion of gastric ulcer. We concluded that, curcumin is considered a promising supplement in attenuating gastric ulcer through its important role in depletion of oxidative stress and inflammation.

Effects of Curcumin and Silymarin on the bacterium Shigella dysenteriae and Campylobacter
Journal of Gastrointestinal Cancer, September 2019
In this study, curcumin and silymarin could inhibit the growth of S. dysenteriae and C. jejuni and 100 μg/ml sub-MIC levels exhibited the suppression of housekeeping genes. Combating pathogenic bacteria by compounds alternative to antibiotics in the era of antibiotic resistance is a proper strategy, though more studies using combinations of them are needed.

High blood pressure: Could this popular spice lower your bp reading?
Express, September 2019
One study suggests the super spice may also help to lower a blood pressure spike. According to Dr Sinatra, turmeric’s potential blood pressure reducing benefits come from its active ingredient, as he explained: “Its [turmeric] yellow colour comes from curcumin — a powerful antioxidant and anti-inflammatory compound that’s been found to reduce blood pressure by lowering the excess platelet aggregation that occurs in sticky, clot-forming blood." Turmeric could help to control a soaring blood pressure High blood pressure: Turmeric could help to control a soaring blood pressure (Image: Getty Images ) Researchers in a study, published in the journal Scientific Reports, concluded that curcumin works much the same way as ginger as it inhibits the transport of calcium, which acts as a chemical messenger that tells muscle cells to contract, thereby dilating the arteries. Therefore, taking turmeric for high blood pressure, due to its active ingredient curcumin, could be an effective remedy.

Anti-infective Properties of the Golden Spice Curcumin
Frontiers in Microbiology, September 2019
The search for novel anti-infectives is one of the most important challenges in natural product research, as diseases caused by bacteria, viruses, and fungi are influencing the human society all over the world. Natural compounds are a continuing source of novel anti-infectives. Accordingly, curcumin, has been used for centuries in Asian traditional medicine to treat various disorders. Numerous studies have shown that curcumin possesses a wide spectrum of biological and pharmacological properties, acting, for example, as anti-inflammatory, anti-angiogenic and anti-neoplastic, while no toxicity is associated with the compound. Recently, curcumin’s antiviral and antibacterial activity was investigated, and it was shown to act against various important human pathogens like the influenza virus, hepatitis C virus, HIV and strains of Staphylococcus, Streptococcus, and Pseudomonas.

Turmeric For Rheumatoid Arthritis
Medicaldaily.com September 2019
According to a review article published in the US National Library of Medicine, turmeric is rich in curcumin that has an antioxidant effect, lowers blood sugar, is anti-inflammatory and affords anticancer benefits. Since rheumatoid arthritis is an autoimmune disease that mistakenly attacks healthy joint tissue, patients experience inflammation that leads to bone and joint damage. The anti-inflammatory properties of turmeric could alleviate its symptoms. Curcumin In a 2016 systematic review, researchers measured the effectiveness of turmeric and curcumin extracts on arthritis patients. Those who took 1,000 milligrams of curcumin daily for eight to 12 weeks reduced their pain sensations and inflammation which are common symptoms of osteoarthritis. Researchers found that curcumin extracts are effective in treating these symptoms by recommending patients to take nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and diclofenac. They, however, noted that there is a need for further research to confirm their findings. Nevertheless, they recommended that arthritis patients may use curcumin as a dietary supplement while undergoing conventional therapy. A subsequent study looked into the effects of curcumin on rats with rheumatoid arthritis. Researchers determined that the component reduced inflammation and redness among the lab rats by blocking an intercellular signaling process called mTOR pathway.

Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of green tea extract
BMC Complementary and Alternative Medicinevolume 19, September 2019
Curcumin, obtained from Curcuma longa, is used as bio-enhancer for anti-microbial agents and anti-cancer drugs. It shows strong antioxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties. Curcumin can recover chemically-induced oxidative stress as well as increase xenobiotic detoxifying enzymes’ activities in both the liver and kidneys and suppress lipid peroxidation. Curcumin has low solubility and low permeability from intestine due to P-glycoprotein pump (P-gp). Curcumin acts by two mechanisms:suppression of drug metabolising enzymes in liver and inducing changes in drug transporter P-gp. Curcumin is initially absorbed from intestine, but is effluxed again inside intestine by P-gp. Curcumin and EGCG both are effluxed by P-gp; hence curcumin can play a pivotal role of inhibiting P-gp, thereby enhancing permeation of EGCG by inhibiting its efflux.

Understanding use of turmeric in herbal medicine
Guardian, September 2019
Curcumin, the major active ingredient in Turmeric has a wide range of medicinal activities and it is composed of phytochemicals, mineral/vitamins and dietary fiber. Minerals in curcumin are magnesium, potassium, sodium, iron, manganese, calcium, phosphorus and selenium. The following vitamins are included in Turmeric, vitamins C, E, K, B6 and folate. Turmeric is a very good source of dietary fiber and fatty acids are w-fatty acid and alpha-linolenic acid. Curcumin possesses anticancer properties along with anti-inflammatory, anti-Alzheimer’s and anti-tumour potentials. It also has hepatoprotective, neuroprotective, cardioprotective, anti-rheumatic, anti-diabetic, hypoglycemic and analgesic activities. The essential oils in curcumin are ar-turmerone, alpha-turmerone and beta-turmerone and they are biologically active constituents. These essential oils are endowed with anti-cancer, anti-inflammatory, antimicrobial and antioxidative potentials. The curcuminoids and the volatile essential oils are responsible for the health benefits of turmeric.

7 Benefits of Turmeric
News18.com September 2019
1.Acts against Inflammation: Inflammation can become a major problem when it becomes chronic, inappropriately attacks body’s own tissues. Curcumin, a compound found in turmeric, is a naturally and strongly anti-inflammatory. It matches the effectiveness of some anti-inflammatory drugs, without the side effects. 2.Increases Antioxidant Capacity: Antioxidants are beneficial for the body as they protect it from free radicals, which tend to react with important organic substances, such as fatty acids, proteins or DNA. Curcumin has powerful antioxidant effects, which neutralizes free radicals on its own and stimulates body’s own antioxidant enzymes. 3.Lowers the risk of heart disease: Curcumin can help reverse many steps in the heart disease process, as it improves the function of the endothelium, which is the lining of your blood vessels. 4.Helps in Skin Care: Turmeric keeps the skin healthy in many ways, such as keeping pimples at bay by inhibiting the growth of pimple, clearing acne scars and making your skin flawless, healing of a cut and soothing skin irritation, and fighting signs of ageing like wrinkles and pigmentation by curbing the growth of free radicals. 5.Helps in Weight Loss: Turmeric helps in accelerating the metabolism rate and letting the body burn a significant number of calories, leading to weight loss. It is also useful in reducing fat mass and detoxification of the liver, which are essential contributors when it comes to diet-induced weight loss efforts. 6.Improves Brain Function: Turmeric is known to boost cognitive abilities, increase concentration, and boost memory retention. It also protects the neural pathways from long-term oxidative stress and the build-up of plaque. 7.Treats Depression: Curcumin has a similar effect like Prozac on patients suffering from depression, mood swings, anxiety, and stress, making it a powerful alternative to pharmaceutical routes, which often have dangerous or addictive side effects.

Curcumin Inhibits Proliferation and Migration of A549 Lung Cancer Cells
Natural Product Communications, August 2019
Curcumin is a major component of turmeric with promising tumor-suppressive activity; however, its underlying molecular mechanisms need to be investigated further. Collectively, our data suggested that curcumin induces autophagy via activating the ERK1/2 pathway and the autophagy is important for the inhibiting effect of curcumin in lung adenocarcinoma cells.

Curcumin plays a dual role: in adjuvant therapy and reversal of drug resistance in acute myelogenous leukemia
journalcmpr, August 2019
The results obtained highlight the potential of curcumin in enhancing the efficacy of cyt and overcoming drug resistance in AML. Thus, this study shows that curcumin may effectively be used as an adjuvant therapy in AML.

Benefits of curcumin in brain disorders
Biofactors. 2019 August, 2019
Curcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti-inflammatory, anti-cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This review summarizes available data from several recent studies on curcumin in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Huntington's disease, Prions disease, stroke, Down's syndrome, autism, Amyotrophic lateral sclerosis, anxiety, depression, and aging. This review also summarizes the ongoing clinical trials on curcumin for different neurodegenerative diseases and patent details of curcuma/curcumin in India.

Cardiac Rehabilitation-Curcumin, Cardiovascular Disease, Heart Failure
peoplebeatingcancer.com August 2019
Curcumin supplementation can: attenuate adriamycin-induced cardiotoxicity reduce my cholesterol reduce my risk of DVT and stroke helps dissolve my post-thrombotic syndrome All is one inexpensive, non-toxic nutritional supplement. If it sounds as though curcumin is a wonder drug, it is. Curcumin also is cytotoxic (kills) to my cancer, multiple myeloma.  “Curcumin (diferuloylmethane) is a polyphenol responsible for the yellow color of the curry spice turmeric. It has been used in a variety of diseases in traditional medicine. Modern scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular protective effects. In this review, we focused mainly on the effects of curcumin on the cardiovascular system. The antioxidant effects of curcumin have been shown to attenuate adriamycin-induced cardiotoxicity and may prevent diabetic cardiovascular complications. The anti-thrombotic, anti-proliferative, and anti-inflammatory effects of curcumin and the effect of curcumin in decreasing the serum cholesterol level may protect against the pathological changes occurring with atherosclerosis. The p300-HAT inhibitory effects of curcumin have been demonstrated to ameliorate the development of cardiac hypertrophy and heart failure in animal models. The inflammatory effects of curcumin may have the possibility of preventing atrial arrhythmias and the possible effect of curcumin for correcting the Ca(2+) homeostasis may play a role in the prevention of some ventricular arrhythmias. The preclinical studies from animal to clinical data in human are discussed.” Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials “Conclusions- Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs.

Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment
Molecular Medicine, August 2019
Curcumin has been shown to have a broad range of antioxidant, antibacterial, antifungal, antiviral, anti-inflammatory, anti-proliferative, and pro-apoptotic properties (Aggarwal & Sung, 2009). Curcumin has also been reported to have anti-fibrotic capabilities in studies of wound healing, liver fibrosis and lung fibrosis models (Lin et al., 2009; Yao et al., 2012; Zhang et al., 2011; Smith et al., 2010; Chen & Zheng, 2008). At the molecular level, curcumin has been reported to play an anti-fibrotic role by modulating transcription factors such as transforming growth factor beta (Chen et al., 2013; Liu et al., 2016), platelet-derived growth factor, fibroblast growth factor and tumor necrosis factor alpha (Shishodia, 2013; Hua et al., 2013; Das & Vinayak, 2014), all of which are implicated in the pathogenesis of IPF. Due to these antifibrotic properties of curcumin, a number of investigators have hypothesized that this compound could serve as a possible therapeutic for IPF (Smith et al., 2010; Liu et al., 2016; Xu et al., 2007). These studies focus on the antifibrotic effects of curcumin and, like many other in-vitro studies, report a reduction in profibrotic responses when pulmonary fibroblasts are treated in isolation.

Foods to Feed Both Body and Mind
Entrepeneur.com  August 2019
Turmeric is the spice that gives curry its yellow color. Curcumin is the main active ingredient in turmeric. This spice is found in foods from India, Indonesia and Thailand, and has been shown to have any great health benefits. Curcumin is known to boost brain function and lower the risk of brain disease because it increases the levels of an important growth hormone in the brain known as the brain-derived neurotrophic factor. Many of the studies researching the benefits of turmeric use extracts that contain mostly curcumin, in quantities exceeding one gram per day. In order to get the full effects, you may consider taking a supplement that contains curcumin.

Yellow curry spice turmeric could prevent stomach cancer
The London Economic, July 2019
The active ingredient curcumin suppress cancer cells and induces apoptosis, or “cell death”, researchers discovered. The review found that curcumin, derived from the roots of the turmeric plant, could also work against gastric tumors. Professor Danielle Queiroz Calcagno said that researchers undertook a vast scientific review. She said: “We looked at all nutrients and bioactive compounds with the potential to prevent or treat stomach cancer and found that curcumin is one of them. “These compounds can favour the activation or repression of genes involved in the development of stomach cancer by promoting or inhibiting histone acetylation.” Curcumin influences histones by inhibiting acetyltransferases to suppress cancer cells and induce apoptosis, or cell death.

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease
Critical Reviews in Food Science and Nutrition, July 2019
Curcumin is known to reverse vari- ous ailments of the nervous system, cardiovascular system, digestive system, respiratory system, endocrine system, renal system, etc. According to recent and well-designed clinical study, consumption of curcumin exerts beneficial effect against metabolic syndrome, skin diseases, cancer, gut inflammation, depression, arthritis, fatty liver disease and premenstrual syndrome. Furthermore, the anti-inflammatory and antioxidant potential of curcumin supplementation for its beneficial effect against arthritis and metabolic syndrome has been reviewed. Curcumin has been reported to bind directly to signaling molecules, such as carrier proteins, DNA methyltransferases 1, xanthine oxidase, human immunodeficiency virus (HIV)- 1 integrase, filamenting temperature-sensitive mutant Z (FtsZ) protofilaments, glyoxalase I, proteasome, histone deacetylase, histone acetyltransferase, cell survival proteins, HIV-1 protease, protein reductases, protein kinases, inflam- matory molecules and metal ions (Gupta et al. 2011). Curcumin treatment modulated b-secretase 1 (BACE-1), acetylcholinesterase (AChE) activity, chemokines, toll-like receptor (TLR), cyclooxygenase (COX), brain-derived neuro- trophic factor (BDNF), tropomyosin receptor kinase B (TrkB), c-Jun N-terminal kinase (JNK), insulin receptor substrate-1 (IRS-1), inhibitor of NF-kB (IkB), glutathione-S- transferase, endothelial haeme oxygenase-1 (HO-1), extracel- lular receptor kinases (ERKs), low density lipoprotein-recep- tor (LDL-R), activator protein 1 (AP-1), peroxisome proliferator-activated receptor-gamma (PPAR-c), liver X receptor-b(LXR-b), retinoid X receptor (RXR)-a, c-Jun and tumor necrosis factor alpha (TNF-a) (Ray and Lahiri 2009; Hamaguchi, Ono, and Yamada 2010; Farooqui 2013; Tian et al. 2013). Curcumin treatment is reported to exert its beneficial effect through various kinases such as focal adhe- sion kinase (FAK), acid activated protein kinase C (AAPK), epidermal growth factor receptor-kinase (EGFRK), protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK), protein kinase A (PKA), protein kinase B (PKB), ERK, p21-activated kinase (PAK), janus kinase (JAK), inter- leukin (IL)-1, Rak and pp60C-TK. Curcumin also demon- strates significant action via growth factors like fibroblast growth factor (FGF), hepatocyte growth factor (HGF), epi- dermal growth factor (EGF), platelet-derived growth factor (PDGF), transforming growth factor-b1 (TGF-b1) and vas- cular endothelial growth factor (VEGF). Cytokines such as IL-1b, IL-1, IL-6, IL-8, IL-12, TNF-aand monocyte chemo- attractant protein-1 (MCP-1), and several transcription fac- tors like nuclear factor kappa B (NF-kB), Ap-1, Notch-1, CREB-binding protein (CREB-BP), early growth response-1 (Egr-1), Wilms’tumor gene 1 (WT-1), b-catenin, hypoxia- inducible factor-1 (HIF-1), nuclear factor 2-related factor (Nrf-2) and estrogen response element (ERE) are also the molecular targets of curcumin (Kunnumakkara et al. 2017; Derosa et al. 2016; Sahebkar et al. 2016). Curcumin exerts beneficial effects through various receptor such as integrin receptor (IR), Fas receptor (Fas-R), EGFR, HER-2, IL-8R, C- X-C chemokine receptor type 4 (CXCR4), estrogen receptor- alpha (ER-a), endothelial cell protein C receptor, histamine (2)-receptor (H2R), LDL-R, androgen receptor (AR) and DR-5.

Anti-infective Properties of the Golden Spice Curcumin
Frontiers in Microbiology, July 2019
The search for novel anti-infectives is one of the most important challenges in natural product research, as diseases caused by bacteria, viruses, and fungi are influencing the human society all over the world. Natural compounds are a continuing source of novel anti-infectives. Accordingly, curcumin, has been used for centuries in Asian traditional medicine to treat various disorders. Numerous studies have shown that curcumin possesses a wide spectrum of biological and pharmacological properties, acting, for example, as anti-inflammatory, anti-angiogenic and anti-neoplastic, while no toxicity is associated with the compound. Recently, curcumin’s antiviral and antibacterial activity was investigated, and it was shown to act against various important human pathogens like the influenza virus, hepatitis C virus, HIV and strains of Staphylococcus, Streptococcus, and Pseudomonas. Despite the potency, curcumin has not yet been approved as a therapeutic antiviral agent. This review summarizes the current knowledge and future perspectives of the antiviral, antibacterial, and antifungal effects of curcumin.

Wikipedia Fails Again: The Case of Misinformation about Curcumin
PRN.fm July 2019
Just in the US official scientific library of medicine with almost 12,000 studies, the evidence overwhelmingly supports curcumin’s medicinal and functional benefits. That does not include the thousands of studies in medical journals in other cournties where turmeric has been used as a nutritional enhancer for millennia. Wikipedia’s absurd statement that “although long used in Ayurvedic medicine… no high-quality clinical evidence exists for use of turmeric or its constituent, curcumin, as a therapy,” requires little comment for the hundreds of pages simply listing research about the herb’s medicinal value. Just a few of the research study titles include: Curcumin administration reduces depressive symptoms in patients with major depression (Phytotherapy Research, 2015) Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia (Pharmacological Research, 2017) Curcumin appears to enhance clearance of amyloid-beta in Alzheimer’s disease patient (Journal of Alzheimers Disease, 2006) Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress (Nutrition Research, 2018) A curcumin extract is appropriate for the care of patients with joint problems and may also contribute to the regeneration of cartilage (Open Rheumatological Journal, 2014) A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut (Cancer Epidemiological Research, 2005) A topical preparation of curcumin successfully decreased the markers of lactational mastitis such as pain, breast tension and erythema within 72 hours of administration (Oman Medical Journal, 2014) Curcumin alleviates ethanol-induced oxidative damage in liver cells (Journal of Ethnopharmacology, 2010) We can trust the accumulation of nearly 12,000 studies in the official peer reviewed data library. We can count upon the countless other studies in the world’s other databases. We can trust the numerous doctors throughout history in culture’s worldwide with proven clinical experience. Or we can trust a tiny group of expert wannabes, Skeptics, who are anonymous and have no noticeable education or experience in nutritional biochemistry and preventative medicine. And this group dominating Wikipedia’s health pages are ideologically and frequently politically aligned with the pharmaceutical industry. This is a long sorted history of Big Pharma relying upon faux scientists, public relations firms and astroturf groups for hire to promulgate its ideology.

Chemopreventive efficacy of oral curcumin: a prodrug hypothesis
Federation of American Societies for Experimental Biology, July 2019
Oral consumption of curcumin, a natural polyphenol, is associated with reduced incidence of cancer. Yet, a significant amount of the orally dosed compound is eliminated in the feces, and a major fraction of the absorbed compound is metabolized to inactive glucuronides, resulting in poor bioavailability (<1%). It is not known how oral curcumin exhibits chemopreventive activity. We propose curcumin glucuronide is an inflammation-responsive natural prodrug that is converted back to curcumin on demand at the site of action. Our studies show elevated levels of β-glucuronidase, an enzyme that hydrolyzes the glycosidic bond of glucuronides to generate the parent compound, in human breast cancer. Oral administration of curcumin in mouse tumor models generated significant tumor levels of the polyphenol. Intravenous administration of the glucuronide resulted in the formation of curcumin in the tumor tissue. Chronic daily oral curcumin dosing led to tumor accumulation of curcumin and inhibition of tumor growth in tumor models with high β-glucuronidase activity. Overall, the study presented here provides preliminary evidence for a novel mechanism of action for orally administered curcumin.

How Turmeric Can Help in Weight Loss
Latestly.com, July 2019
Curcumin is an antioxidant and anti-inflammatory ingredient found in turmeric with weight loss benefits. According to a study conducted by researchers at Tufts University in 2009, curcumin slowed weight gain in mice by preventing new fat tissues from forming. When mice were fed with turmeric it prevented them from developing new blood vessels and less fat tissue. The study also revealed that mice who were fed with this anti-oxidant agent had less fat in their livers and lower cholesterol levels than mice who weren’t. As per the latest study conducted by The Journal of Nutritional Biochemistry, Korean scientist identified that curcumin induces browning in white adipose tissue. There are two types of adipose tissues -- brown and white. White adipose tissue stores energy and increases with weight gain. On the other hand, brown adipose tissue produces heat by burning fat. Curcumin in turmeric stimulates the production of mitochondria which converts sugars, proteins and fat into energy.

Effects of Turmeric on Your Body
Galpost.com, July 2019
Scientists have discovered that curcumin inhibits the production of fat cells and improves the metabolism of carbohydrates, which reduces fat after eating bread, pasta, potatoes and other carbohydrates.

Why All Diabetics Should Know About Turmeric
I Thrive Series, July 2019
A recent literature review published in the International Journal of Endocrinology and Metabolism titled, “Anti-Hyperglycemic Effect and Insulin Sensitizing Effects of Turmeric and Its Principle Constituent Curcumin,” adds promising new support to the notion that the ancient Indian spice turmeric may provide an ideal drug alternative to treating and perhaps even preventing type 2 diabetes, which has become of the world’s most prevalent diagnoses. The study reviewed research published between 1998 to 2013 that indicates the active polyphenol in turmeric known as curcumin may provide an ideal intervention for type 2 diabetes, capable of mitigating characteristic pathophysiological hallmarks of the disease such as elevated blood sugar (hyperglycemia) and insulin resistance. Nineteen of the studies reviewed were cell (in vitro) and animal (in vivo), all which showed beneficial effects. Five of the studies were human clinical trials using turmeric or curcumin, three of which were performed in those with either diabetes or prediabetes. Amazingly, the animal and cell research literature review concluded that curcumin could improve the type 2 diabetic state through 10 distinctly different mechanisms, such as: Reduction in liver glucose production Reduction in liver glycogen production Stimulation of increased glucose uptake (by increasing GLUT4, GLUT2 and GLUT3 gene expressions) Increasing the activation of AMP kinase Promoting PPAR γ ligand- binding activity Suppressing hyperglycemia-induced inflammatory state Stimulating insulin secretion from pancreatic tissues Improvement in pancreatic cell function, Increasing phosphorylation of AKT Increasing insulin receptor β and reduction of insulin resistance The human clinical research conducted on diabetic and pre-diabetic patients revealed that curcumin had the following beneficial effects: Glucose lowering effect Improved beta cell function Improved fatty acid oxidation and utilization

Effects of Notch Signaling Pathway in Cervical Cancer by Curcumin
Journal of Cancer, July 2019
Curcumin, as a high effectand low toxicity anti-cancer drug and photosensitiser, has synergisticand complementaryeffects with photodynamic therapy. We found both DAPT and curcumin-PDT can inhibit the proliferation and induce apoptosis of cervical cancer cell.

Can Turmeric Help Prevent or Treat Type 2 Diabetes?
Everydayhealth.com, July 2019
The likely driver of turmeric’s potential health benefits is curcumin, the primary active chemical in this yellow-orange spice. “Curcumin is what has mostly been studied because of its important signaling pathways. It acts mostly in two areas: It's an antioxidant and an anti-inflammatory,” says Marina Chaparro, RDN, MPH, a certified diabetes educator and a national spokesperson for the Academy of Nutrition and Dietetics. a study published in April 2015 in the Indian Journal of Clinical Biochemistry found that human participants who supplemented their Glucophage (metformin) — a diabetes medication that helps lower blood sugar — with turmeric did lower their blood sugar, inflammation, and levels of oxidative stress. In another human study — this one a randomized controlled trial that was published in 2012 in Diabetes Care — a supplement of 250 milligrams of curcumin daily was associated with a delay in participants progressing from prediabetes to type 2 diabetes. Researchers studied 240 people for nine months and reported that at the end of the study, 16.4 percent of people in the placebo group developed type 2 diabetes, versus 0 percent in the curcumin-supplemented group. Participants didn’t report any side effects except for mild stomachaches. Furthermore, in the Diabetes Care study, curcumin notably appeared to help improve the function of beta cells, which research shows help produce the hormone insulin. Insulin is responsible for ferrying glucose to cells, but in type 2 diabetes, cells become insensitive to glucose, leading to high blood sugar. As the pancreas cranks out more insulin to try to lower blood sugar levels, blood sugar remains elevated because of insulin resistance — until it wanes in producing insulin because of beta cell dysfunction.

Pharmacognostic Studies on Curcuma Longa
International Journal of Pharmacognosy and Chinese Medicine, July 2019
The turmeric (Curcuma longa) plant, a perennial herb belonging to the ginger family, is cultivated extensively in south and southeast tropical Asia. The rhizome of this plant is also referred to as the “root” and is the most useful part of the plant for culinary and medicinal purposes. The most active component of turmeric is curcumin, which makes up 2 to 5% of the spice. The characteristic yellow color of turmeric is due to the curcuminoids. Curcumin is an orange–yellow crystalline powder practically insoluble in water. Turmeric is used as a dietary spice, coloring agent in foods and textiles, and a treatment for a wide variety of ailments. It is widely used in traditional Indian medicine to cure biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. Turmeric paste in slaked lime is a popular home remedy for the treatment of inflammation and wounds. For centuries, curcumin has been consumed as a dietary spice at doses up to 100 mg/d. Extensive investigation over the last five decades has indicated that curcumin reduces blood cholesterol, prevents LDL oxidation, inhibits platelet aggregation, suppresses thrombosis and myocardial infarction (MI), suppresses symptoms associated with type II diabetes, rheumatoid arthritis, multiple sclerosis (MS), and Alzheimer’s disease, inhibits human immunodeficiency virus (HIV) replication, enhances wound healing, protects from liver injury, increases bile secretion, protects from cataract formation, and protects from pulmonary toxicity and fibrosis, is an anti-leishmaniasis and an antiatherosclerotic. Additionally, there is extensive literature that suggests that curcumin has potential in the prevention and treatment of a variety of other diseases.

Turmeric and its medicinal properties
Guardian, July 2019
Curcumin is the yellow pigment in Turmeric and the most medicinally active compound therein. Curry, the very common spice that we add to our stews and soups is from curcumin. There are about100 chemical compounds in turmeric. These chemical compounds confer certain uniqueness to this herb and give it the ability to treat several disease conditions. The curcumin in turmeric is made up of polyphenols, which are organic chemicals that possess anti-inflammatory properties. Polyphenols are also present in some other types of foods and beverages also. Examples of these are epigallocatechin gallate (ECGC) found in green tee, resveratrol in red grapes and red wine and capsaicin in chili peppers. Curcumin is part of a group of chemical compounds known as curcuminoids and others in the group are demethoxycurcumin and bisdemethoxycurcumin. Curcumin is what is responsible for the health benefits of turmeric.

Tips to increase brain power
Newstracklive.com, July 2019
Turmeric: The curcumin in turmeric is antidepressant and helps improves memory. It has been found that people suffering from Alzheimer’s have small proteins called amyloid-beta which causes damage to the brain. It is neurotoxic and forms neurofibrillary tangles in the brain that leads to Alzheimer’s. Curcumin works to protect the brain from this damage.

The Wonders of Turmeric: Why It’s Good For You
Society19, July 2019
One of the reasons why turmeric is good for you because it is anti-inflammatory. Turmeric contains curcumin, a chemical that not only is responsible for the bright yellow colour, but is said to contain anti-inflammatory properties. In some cases, curcumin is so potent that it can be as effective as anti-inflammatory drugs. One study actually discovered that curcumin was more effective in fighting against inflammation than aspirin and ibuprofen. Another reason why this spice is good for you is that it can prevent cancer. As mentioned above, curcumin has anti-inflammatory properties, but that is not the only thing it can do. Curcumin is also beneficial in treating cancer, as it affects cancer growth and development. One study has discovered that curcumin can inhibit tumor initiation and promotion, as well as inhibit metastasis and cell proliferation. Considering that turmeric contains curcumin, it is no surprise that the yellow spice is beneficial to the joints and can prevent them from getting swollen and inflamed. It has been discovered that curcumin is able to help with arthritis, including rheumatoid arthritis, to the point that it is considered to be more effective than anti-inflammatory drugs.

Turmeric, ‘The Golden Spice’ is 1 of the Most Beneficial Spices in World
Live Trading News, July 2019
Turmeric, known as ‘The Golden Spice of Life’ is of the most beneficial spices in the culinary world. It is due to the astounding amounts of curcumin it contains, its principal bioactive component. According to a Y 2017 study published in the journal Foods, curcumin contains antioxidant and anti-inflammatory properties since ancient times known to assist in alleviating arthritis, metabolic syndrome and hyperlipidemia. A 2016 study from Drug Design, Development and Therapy showed that curcuminoids and curcumin extracts helped alleviate pain and improved both physical function and quality of life.7 •May help improve behavioral symptoms of Alzheimer’s and dementia — A Y 2012 study found that the daily administration of turmeric to Alzheimer’s disease and dementia patients helped reduce irritability, agitation, anxiety, apathy and other Alzheimer’s disease symptoms. •Provides an immune system boost — According to a Y 2018 study from the Journal of Cellular Physiology, curcumin affects numerous immune cells, including natural killer cells and B lymphocytes, supporting the body against immune system-related diseases.

Life-saving compound can DESTROY stomach cancer
Healthier Talk, July 2019
Curcumin appears to attack the protein that keeps the DNA of each cancer cell in order. So essentially it causes the DNA to unravel – forcing those cells to die. While this animal study isn’t quite on the same level as a controlled clinical trial, the evidence has been building for years. And the signs all point to curcumin being a potent weapon in the war against stomach cancer. Curcumin could starve cancer cells In 2017, a study even showed WHY curcumin is so effective: The acids in your stomach can act like fertilizer for these cancers. The tumors suck it up and use it to GROW. Curcumin can help tame those acids, not necessarily by reducing the levels but changing how they’re secreted so less gets to the tumor. As a result, the cancer cells in the study weren’t able to get that fertilizer… and DIED because of it. More study is needed, of course. But that makes curcumin one of the most promising natural therapies yet in the fight against stomach cancer. That could mean that if you DON’T have cancer, curcumin supplements can prevent it from forming and taking hold. And if you DO have cancer, curcumin could help fight it off.

Natural Remedies Proven to Help Control Pain
Care2, July 2019
Scientists believe most of turmeric’s health benefits come from its high curcumin content. One of curcumin’s proven abilities is helping to combat pain, such as muscle pain and post-surgical pain. In an Indian study, curcumin was shown to be more effective for relieving rheumatoid arthritis pain than standard drug treatment. You can buy prepared turmeric and curcumin supplements. Fresh or dried turmeric is also easy to incorporate into many different dishes and include in your daily diet. The curcumin in turmeric can be difficult to digest, but research has shown that curcumin is much more easily absorbed when it’s eaten with black pepper and fats. So, add a dash of pepper and a dab of olive, coconut or other healthy oil in your meals to get the most pain-fighting action out of your turmeric.

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach
Biofactors, July 2019
Curcumin (diferuloylmethane) is a potent anti‐inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
Journal of Experimental and Clinical Cancer Research, July 2019
Numerous studies have presented that curcumin could have a positive effect in the prevention of cancer and then in tumor therapy. Several hypotheses have highlighted that curcumin could decreases tumor growth and invasion by acting on both chronic inflammation and oxidative stress. Curcumin (1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a natural product which occurs polyphenolic phytochemical properties from the rhizome of the Curcuma longa. Curcumin has been discovered in 1815 by Vogel and Pelletier. Its yellow-colored hydrophobic component is traditionally used in Asian countries for its several properties against pathophysiological states including anticancer . Several targets of curcumin have been shown to have chemotherapeutical properties. Curcumin use may have a major role in the control of inflammation, angiogenesis, metastasis and proliferation . Curcumin can downregulate numerous pathways, such as nuclear factor-ϰ B (NF-ϰB), cyclooxygenase-2 (COX-2), and the canonical WNT/β-catenin pathway. The use of curcumin, which acts as PPARγ agonists, could be interesting in the reduction of both chronic inflammation and oxidative stress, and in the control of circadian clock by inhibiting the WNT/β-catenin pathway. Due to the considerable impact of cancers on mortality and morbidity rates worldwide, it would appear of the utmost importance to better understand the action of curcumin in cancers and particularly its role in the inhibition of the major signaling system known as the WNT/β-catenin pathway.

Discover The Proven Health Benefits Of Turmeric And Curcumin
Scoopify, July 2019
Curcumin benefits in the prevention of the growth of the precancerous cells in the colon. Not only this, it has been highly beneficial in the treatment of the breast, stomach and skin cancer during the initial phase. Curcumin has the presence of anti-inflammatory and antioxidant properties that help in maintaining the insulin level in the body.

Feed addition of curcumin to laying hens showed anticoccidial effect, and improved egg quality and animal health
Pubmed, July 2019
The addition of curcumin in the diet of laying hens has an anticoccidial effect and improves egg quality.

Curcumin Induces Oxidative Stress in Botrytis cinerea
Pubs.acs.org, July 2019
Curcumin exhibits efficient antimicrobial activity; nevertheless, its effect on the postharvest decay of fruit has not been examined. Curcumin can be used to control gray mold and elevate antioxidant activity in kiwifruit.

Health Benefits of Turmeric & Curcumin
OrganicFats.net June 2019
The amazing health benefits of turmeric and curcumin include the ability to reduce inflammation, heal wounds, improve skin health, protect cognitive abilities, and ease menstrual difficulties. Turmeric also helps eliminate depression, alleviate pain, slow down aging, protect the digestive tract, and prevent cancer. Turmeric rich in curcumin and vitamin B6 also boosts your cardiovascular health. Vitamin B6 can efficiently inhibit the production of homocysteine, which is a negative by-product that damages cell walls. These weakened walls can cause a number of complications in the heart, particularly when exacerbated by high blood pressure or plaque build-up. Curcumin directly balances your cholesterol levels by eliminating excess LDL (bad) cholesterol from the arteries and blood vessels. This can help prevent atherosclerosis and when combined with stronger blood vessels, the herb represents a comprehensive solution for a wide range of heart issues, as per a study cited in the Basic Research in Cardiology. Anti-cancer Properties A study conducted on mice by the researchers at the Cancer Research Institute, Tata Memorial Center, Mumbai, India documents the potential protective effect of turmeric on stomach and skin cancer. The most extensive research on turmeric’s cancer prevention effects has been in colon cancer, whereas other types of cancer research related to curcumin are currently underway. Additionally, an animal study by Ramadasan Kuttan et al. (Cancer Letters Journal) indicated that the turmeric extract and curcumin inhibited the growth of the tumor. Researchers at The University of Texas M. D. Anderson Cancer Center found that curcumin’s potential ability to kill cancer cells can be used in drug development. Additional studies need to be done to get the health benefits of this spice pertaining to cancer. Prevents Alzheimer’s As a powerful antioxidant herb, turmeric can stimulate neural activity and prevent cognitive degradations, which often come in the form of Alzheimer’s and dementia. As per a study by Srikant Mishra from the Department of Neurology, Plummer Street, Sepulveda, CA, curcumin is highly efficient in clearing out the amyloid plaque, which is a major indicator of Alzheimer’s progression. A study also found that turmeric supplements improved mood and cognitive function in non-demented older people suffering from mild age-related memory issues.

Evaluating the effect of curcumin for treatment of cancer anorexia-cachexia syndrome in solid cancer patients.
Journal of Clinical Oncology, June 2019
Curcumin has been shown anti-cancer and anti-inflammatory effects, including attenuation of CACS in animal models. Notably, patient with curcumin had less reduction of hand-grip muscle strength on both hands [right hand: -2.09 in curcumin versus -3.68 in placebo; p = 0.46], [left hand: -1.24 versus -5.04; p-value = 0.12], and basal metabolic rate than placebo group.

A network pharmacology approach to investigate the pharmacological effect of curcumin and capsaicin targets in cancer
Journal of Proteins and Proteomics, June 2019
Curcumin and capsaicin play a vital role in anti-inflammatory and anti-cancer mechanism as they are used as therapeutic drugs/adjuvants. The gene ontology analysis made it possible to identify a library of possible cancer targets of curcumin (34 targets) and capsaicin (35 targets). Based on topological analysis, the unique target of curcumin and capsaicin was proposed by identifying essential bottleneck/hub node MAPK1. The docking results of MAPK1 with curcumin (− 7.6 kcal/mol) has shown good inhibitory effect similar to that of standard control ulixertinib (− 8.1 kcal/mol) compared with capsaicin (− 6.0 kcal/mol). Based on the molecular interaction, MAPK1 identified through the network pharmacology approach could be a probable target of curcumin and capsaicin to prevent angiogenesis in cancer.

Curcumin reverses oxaliplatin resistance in human colorectal cancer
OncoTargets and Therapy, June 2019
Studies have shown that curcumin regulated EMT processes in many human cancers. The OXA-resistant cell line HCT116/OXA was successfully established, and combination of OXA with curcumin reduced OXA resistance in vitro. Besides, the combination treatment inhibited the expressions of p-p65 and Bcl-2, but increased the level of active-caspase3. In addition, curcumin inhibited EMT via regulation of TGF-β/Smad2/3 signaling pathway. Moreover, in vivo study confirmed curcumin could reverse OXA resistance in CRC. Conclusion: Our study indicated that curcumin could reserve OXA resistance in CRC through dampening TGF-β/Smads signaling in vitro and in vivo.

Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells
Cellular & Molecular Biology Letters, June 2019
urcumin reversed growth inhibition and migration capability of human peritoneal mesothelial cells (HPMCs). In HMrSV5 cells, high glucose PDS also decreased expression of epithelial markers, and increased expression of mesenchymal markers, a characteristic of EMT. Real-time RT-PCR and western blot revealed that, compared to the 4.25% Dianeal treated cells, curcumin treatment resulted in increased expression of E-cadherin (epithelial marker), and decreased expression of α-SMA (mesenchymal markers) (P < 0.05). Furthermore, curcumin reduced mRNA expression of two extracellular matrix protein, collagen I and fibronectin. Curcumin also reduced TGF-β1 mRNA and supernatant TGF-β1 protein content in the PDS-treated HMrSV5 cells (P < 0.05). Furthermore, it significantly reduced protein expression of p-TAK1, p-JNK and p-p38 in PDS-treated HMrSV5 cells. Conclusions. Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs.

Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection
International Journal of Molecular Sciences, June 2019
Curcumin, the biologically active, hydrophobic, phenolic component of turmeric (Curcuma longa), is a natural product commonly utilized in Ayurdevic and traditional medicine, both topically and orally, for its potent effects on multiple body systems. Curcumin, also known as diferuloylmethane, has been a popular supplement largely because of its affordability and safety, with no known toxic side effects in humans up to doses of 12 g/day. In this review, we discussed the potential protective effects of curcumin on intestinal inflammatory diseases. Recent research has focused on the effects of natural anti-inflammatories, such as curcumin, on intestinal inflammatory diseases, largely due to their safety profile and affordability. Curcumin is characterized by beneficial effects on the microbiome, antimicrobial properties, inhibition of TLR4/NF-κB/AP-1 signal transduction, changes in cytokine profiles, and alterations to immune cell maturation and differentiation. The culmination of the vast number of effects of curcumin on the intestinal epithelium and immune system is to strengthen the intestinal barrier through a reduction in bacterial translocation and inflammation. Curcumin may play a significant role in intestinal inflammatory disease treatment in the future, particularly as an adjuvant therapy.

Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
International Journal of Molecular Sciences, June 2019
The natural source of curcumin is the rhizome of the medicinal plant, Curcuma longa, a perennial herb in the family Zingiberaceae. The curcuminoid complex, found in the rhizome of turmeric (2.5–6%) contains: curcumin (CUR - diferuloylmethane, ~85%); demethoxycurcumin (DEM, ~15%); bis-demethoxycurcumin (bis-DEM, ~5%) and cyclocurcumin.  Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging.  Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin.

Curcumin: A Potent Protectant against Esophageal and Gastric Disorders
International Journal of Molecular Sciences, June 2019
Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention and treatment of many diseases since the ancient times. Curcumin is the principal polyphenol isolated from turmeric, which exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities. The existing evidence indicates that curcumin can exert a wide range of beneficial pleiotropic properties in the gastrointestinal tract, such as protection against reflux esophagitis, Barrett’s esophagus, and gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and necrotizing agents. The role of curcumin as an adjuvant in the treatment of a Helicobacter pylori infection in experimental animals and humans has recently been proposed. The evidence that this turmeric derivative inhibits the invasion and proliferation of gastric cancer cells is encouraging and warrants further experimental and clinical studies with newer formulations to support the inclusion of curcumin in cancer therapy regimens. Curcumin, the natural phenolic active ingredient of turmeric (Curcuma longa) rhizome, has been used in Asia as an herbal remedy for a variety of diseases. In addition to the use of curcumin as an anti-inflammatory in ancient times, it has also been used to treat gastrointestinal (GI) diseases such as indigestion, flatulence, diarrhea, and even gastric and duodenal ulcers. Recently, great attention has been paid to the medical applications of curcumin in the treatment of human diseases associated with oxidative stress and inflammation, including different cancers. Curcumin treatment has also led to the improvement of metabolic parameters involving aging-associated diseases such as atherosclerosis, diabetes, cardiovascular disease, and chronic kidney diseases. Interestingly, some promising effects of curcumin have been observed in the alleviation by this turmeric derivative of the chronic inflammatory conditions such as arthritis, uveitis, and inflammatory bowel disease. In some instances, curcumin has been found to aid in the prevention and treatment of various cancers. Recently, the anticarcinogenic activity of curcumin has been documented in the GI tract because this compound has proven to exert a therapeutic effect on different human GI cancers such as esophageal, gastric, and small and large intestinal cancer.

Curcumin in Autoimmune and Rheumatic Diseases
Nutrients, June 2019
Curcumin is the main component of turmeric, also known as the Curcuma longa, which belongs to the ginger family, Zingiberaceae. Curcumin is commonly used in Indian and Asian cooking as a spice for its flavor and yellow color profile. In addition to its consumption due to flavor, curcumin has been used for its medicinal properties for thousands of years.  The curcuminoids found in turmeric are curcumin, desmethoxycurcumin, and bisdemethoxycurcumin, with curcumin being the main active component. Curcumin was first isolated from turmeric in 1815. Curcumin gives turmeric its yellow color and is known to possess most of the therapeutic effects of turmeric. In 1937, the first article published on the use of curcumin in treating human disease cited its beneficial effects in biliary disease. Since then, continued research has shown that curcumin can alleviate a number of human diseases. Studies performed on animals have shown a direct relationship between increased cellular curcumin concentrations and its ability to modulate inflammatory mediators. Experimental studies on cell lines and humans have confirmed the findings from animal studies, demonstrating that curcumin plays a role in anti-inflammatory response via inhibition of the COX-2 pathway and NF-kB activation. In more recent years, numerous studies have shown that curcumin possesses potential anti-inflammatory, anti-oxidant, anti-diabetic, and anti-cancer properties. These studies indicate that curcumin acts on numerous targets with various mechanisms of action, altering enzyme, receptor, and transcription factor activity. In addition, curcumin administration has reported nearly no side effects, making it a potential alternative to NSAIDs and other medications with known severe adverse effects. Curcumin has been used in Indian and Asian medicine for its therapeutic abilities for thousands of years. Recent studies provide evidence that increased curcumin levels can modify cellular disease mechanisms toward a more anti-inflammatory profile. This mainly occurs by inhibition of the COX and lipoxygenase pathway. Additionally, curcumin suppresses NF-κB pathway to decrease inflammation. In addition to its anti-inflammatory effects, curcumin also exerts anti-oxidative capacity. The involvement of these pathways in normal rheumatic disease progression could possibly explain curcumin’s therapeutic effects targeting these disease processes. Many positive outcome clinical trials in OA present solid evidence of curcumin’s beneficial role in disease progression. In addition, curcumin shows similar efficacy to common NSAIDs such as ibuprofen, which cause serious GI side effects. Conversely, curcumin has shown to have little or no side effects.

Foods That Help Fight Anxiety
News 18, June 2019
Turmeric: The spice contains curcumin, a compound that promotes brain health and prevents anxiety disorders. Curcumin may boost omega-3 fatty acid DHA in the brain by helping the body produce it more effectively. Curcumin also has powerful antioxidant and anti-inflammatory properties that help prevent damage to brain cells.

The effect of ultraviolet radiation and the antioxidant curcumin on the longevity, fertility, and physical structure of Drosophila melanogaster
Emerging Investigators, June 2019
Curcumin significantly prolonged lifespan and enhanced fertility for both UV- and non-UV-exposed flies. Therefore, we conclude that curcumin can prolong lifespan, enhance fertility, and mitigate the deleterious effects of UV radiation on Drosophila. Our research demonstrates that we can harness the positive potential of natural antioxidants and use them as weapons in our war against radiation-induced diseases, including conditions like cancer.

The Inhibitory Effect of Curcumin on Ornithine Decarboxylase against Hepatic Carcinoma
Journal of Biosciences and Medicines, June 2019
Curcumin the active component of turmeric is widely used as an anticancer agent for treating many human cancers. Our results showed that curcumin has the ability to inhibit the proliferation of HepG2 cells with IC50 of 24.79 μg/ml and induced G2/M cell cycle arrest. Moreover, it caused an elevation in the intracellular concentration of Ca2+. Moreover, in the curcumin administration the downregulation expression level of ODC and Bcl-2 genes (p ≤ 0.05) was significant found. On the other hand, upregulation in the expression level of P53, Bax, and caspase-3 genes (p ≤ 0.05). This study concluded that curcumin may be considered as a new saving candidate for the future progress of antitumor agents.

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin
International Journal of Molecular Sciences, July 2019
Anti-inflammatory and antioxidant properties of curcumin might reduce the expression of tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) and restore the imbalance between reactive oxygen species (ROS) production and antioxidant activity. Since curcumin induces apoptosis of inflammatory cells during the early phase of wound healing, it could also accelerate the healing process by shortening the inflammatory phase. Moreover, curcumin might facilitate collagen synthesis, fibroblasts migration, and differentiation.

These Spices May Help In Regulating Blood Pressure
NDTV, June 2019
The golden spice is celebrated for housing powerful antioxidant - curcumin - that protects against vascular dysfunction. It also protects arteries of the heart, which gets affected the most by high blood pressure.

Consuming turmeric everyday can improve memory and happiness: Study
Dunya News ,May 2019
Found in turmeric, curcumin is hailed as an anti-inflammatory with antioxidant properties, and it has also been suggested as a possible reason that senior citizens in India - where curcumin is somewhat of a staple - have lower rates of Alzheimer s disease and better cognitive performance. Published in the American Journal of Geriatric Psychiatry, the research conducted by the University of California Los Angeles set out to examine the effects of the ingredient on people with mild, age-related memory loss. After monitoring curcumin levels in their blood and undergoing cognitive assessments and PET scans, the study found that those who took curcumin saw significant improvement in both memory and mood. In memory tests, the people taking curcumin improved by 28 percent over the 18 months and also showed mild improvement in their overall disposition.

Curcumin ameliorates atherosclerosis
Journal of Cellular Physiology, May 2019
The potential usage of curcumin in diverse human diseases has been widely studied, including arteriosclerosis (AS). We found that curcumin treatment significantly reduced HMEC‐1 cells viability, migration, and the protein levels of MMP‐2, MMP‐9, and vascular endothelial growth factor (VEGF) in the presence or absence of ox‐LDL. Meanwhile, the expression of VEGFR1 and VEGFR2 was repressed by curcumin. miR‐126 was upregulated by curcumin. The abovementioned effects of curcumin on HMEC‐1 cells were all attenuated when miR‐126 was silenced. And also, VEGF was a target gene of miR‐126, and curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling pathways via miR‐126. The effects of curcumin and its regulation on miR‐126 and VEGF were confirmed in the animal model of AS. To sum up, curcumin exerted potent anti‐AS property possibly via upregulating miR‐126 and thereby inhibiting PI3K/AKT and JAK2/STAT5 signaling pathways.

Curcumin and endometrial carcinoma: an old spice as a novel agent
International Journal of Women's Health, May 2019
The yellow Indian spice known as curcumin has been extolled for its healing powers and has recently been adopted for investigation by the scientific community as a potent anti-cancerous agent. Curcumin is a bright yellow-colored Indian spice derived from the herbaceous ginger plant turmeric, also known as Curcuma longa.18 This spice has been used for centuries to treat numerous diseases such as diabetes, atherosclerosis as well as liver, rheumatoid, and infectious diseases.18,19 Recent advances in molecular biology have allowed a more microscopic inspection into the active properties of this pleiotropic chemical (diferuloylmethane), which has proven to effectively interact with numerous signaling molecules within the body. Curcumin seems to show antibacterial,20 anti-inflammatory,21 antioxidant,22 and antimicrobial activities.23 In addition to all its benefits, curcumin also possesses anti-cancerous effects by targeting several important players in cell signaling pathways such as p53,24 MAPKs, ERK, Ras,25 Wnt-β,26 PI3K, and Akt,27 all of which play major roles in tumor progression. Furthermore, this herb, in combination with other agents, is capable of disrupting the cell cycle through its effect on cellular apoptosis by activating caspases as well as downregulating anti-apoptotic gene products (Bcl-X).28 Curcumin can also interact with several molecules involved in proliferation (EGFR and AP-1),29,30 metastasis and invasion (MMP-9),31 angiogenesis (VEGF),32 and inflammation (NF-κB, COX-2, TNF, IL-1, IL-6, IL-2, IL-8, and IL-12, 5-LOX).33–35 Because of its multivalent potential to target several molecules, this spice can be used on various types of cancers including colorectal, leukemia, lymphoma, breast, pancreatic, ovarian, head and neck, lung, prostate, and melanoma.34 An investigation into the available literature concerning curcumin as a potential therapy for cancers of the female reproductive system turned up with no paper studying the effect of curcumin on endometrial carcinoma. Therefore, this review is written to shed light and summarize any available data on the effect of curcumin as a promising therapeutic agent on this specific gynecological cancer.

Curcumin induces cell death in human ovarian cancer
Gynecologic Oncology, May 2019
Curcumin (Cur), a yellow-colored dietary flavor from the plant (Curcuma longa), has been demonstrated to potentially resist diverse diseases, including ovarian cancer, but drug resistance becomes a major limitation of its success clinically. The key molecule or mechanism associated with curcumin resistance in ovarian cancer still remains unclear. The aim of our study was to investigate the effects of curcumin on autophagy in ovarian cancer cells and elucidate the underlying mechanism. Curcumin reduced cell viability and induced apoptotic cell death by MTT assay in human ovarian cancer cell lines SK-OV-3 and A2780 significantly. Electron microscopy, western blot and immunofluorescence staining proved that curcumin could induce protective autophagy. Curcumin can induce protective autophagy of human ovarian cancer cells by inhibiting the AKT/mTOR/p70S6K pathway, indicating the synergistic effects of curcumin and autophagy inhibition as a possible strategy to overcome the limits of current therapies in the eradication of epithelial ovarian cancer.

Curcumin as Antipsychotic Treatment in Patients With Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
Clinical Neuropharmacology, May 2019
Curcumin is a natural polyphenol, which has a variety of pharmacological activities, including antioxidative and neuroprotective effects. The studies showed that curcumin improved the negative symptoms of schizophrenia. There was a significant response to curcumin within 6 months in total PANSS (P = 0.02) and in the negative symptoms subscale (P = 0.04). The promising results of curcumin as an add-on to antipsychotics in the treatment of negative symptoms may open a new and safe therapeutic option for the management of schizophrenia.

Curcumin exhibits an antiviral activity
Antiviral Research, May 2019
Curcumin, a polyphenol, is the main bioactive compound in dietary spice turmeric curcuma longa. It possesses anti-inflammatory, anti-oxidant and anti-neoplastic properties and shows potentials in treating or preventing particular diseases such as oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, hyperlipidemia and cancers. This discovery explains the wide range of effects of curcumin on diverse human diseases and predicts a potential application in treatment of viral infection and virus-associated cancer. As a proof-of-concept, we demonstrated that curcumin is able to efficiently block Kaposi's sarcoma-associated herpesvirus replication and inhibit the pathogenic processes of angiogenesis and cell invasion. An enzymatic assay confirmed that curcumin is an inhibitor of APE1 redox function. Through inhibiting APE1 redox function, curcumin prevents c-jun/c-fos from binding to the AP-1 promoter. Through blocking AP-1 transcriptional activity, curcumin efficiently inhibits KSHV lytic DNA replication and virion production. Curcumin also inhibits KSHV-mediated pathogenesis including angiogenesis and cell invasion.

Curcumin Can Improve Spinal Cord Injury
Cellular and Molecular Neurobiology, May 2019
Curcumin exhibits potent anti-inflammatory and anti-oxidant properties. Curcumin can play an important role in SCI recovery by inhibiting the expression of NF-κB and TGF-β-SOX9. Herein, we review the potential mechanism of curcumin-inhibiting SOX9 signaling pathway in SCI treatment. The inhibition of NF-κB and SOX9 signaling pathway by curcumin has the potentiality of serving as neuronal regenerative mechanism following SCI.

Effect of combined fish oil & Curcumin on murine skeletal muscle
Nutrition Research, May 2019
Nutritional supplements such as fish oil and curcumin enhance anabolic signaling, glutathione levels, and heat shock proteins. We hypothesized that fish oil, rich in omega-3-fatty acids, combined with the polyphenol curcumin would enhance stress protective proteins and anabolic signaling in the rat soleus muscle, concomitant with synergistic protection of morphology. C57BL/6 mice were assigned to 3 groups (n = 6/group): ambulatory controls (CON), hindlimb unloading (HU), and hindlimb unloading with 5% fish oil, 1% curcumin in diet (FOC). FOC treatments began 10 days prior to HU and tissues were harvested following 7 days of HU. FOC mitigated the unloading induced decrease in CSA. FOC also enhanced abundance of HSP70 and anabolic signaling (Akt phosphorylation, p70S6K phosphorylation), while reducing Nox2, a source of oxidative stress. Therefore, we concluded that the combination of fish oil and curcumin prevents skeletal muscle atrophy due to a boost of heat shock proteins and anabolic signaling in an unloaded state.

Curcumin reduces renal damage
Federation of American Societies for Experimental Biology, May 2019
Treatment with curcumin initiated before or after rhabdomyolysis induction ameliorated all these pathologic and molecular alterations. In cultured renal tubular cells, myoglobin (Mb) induced ferroptosis-sensitive cell death that was also inhibited by curcumin. Mechanistic in vitro studies showed that curcumin reduced Mb-mediated inflammation and oxidative stress by inhibiting the TLR4/NF-κB axis and activating the cytoprotective enzyme heme oxygenase 1. Our findings are the first to demonstrate the involvement of ferroptosis in rhabdomyolysis-associated renal damage and its sensitivity to curcumin treatment. Therefore, curcumin may be a potential therapeutic approach for patients with this syndrome.

Curcumin induces apoptosis in JAK2‐mutated cells
Journal of Cellular and Molecular Medicine, May 2019
Previous studies showed that curcumin, the active principle of the Curcuma longa, can suppress JAK2/STAT pathways in different type of cancer and injuries. In this study, we investigated the anti‐proliferative and pro‐apoptotic effects of curcumin in JAK2 V617F‐mutated cells. HEL cell line and cells from patients JAK2 V617F mutated have been incubated with increasing concentrations of curcumin for different time. Apoptosis and proliferation were evaluated. Subsequently, JAK2/STAT and AKT/mTOR pathways were investigated at both RNA and protein levels. We found that curcumin induces apoptosis and inhibition of proliferation in HEL cells. Furthermore, we showed that curcumin inhibits JAK2/STAT and mTORC1 pathways in JAK2 V617F‐mutated cells. This inhibition suggests that curcumin could represent an alternative strategy to be explored for the treatment of patients with myeloproliferative neoplasms.

Curcumin: a potent agent to reverse epithelial-to-mesenchymal transition
Cellular Oncology, May 2019
Accumulating evidence indicates that curcumin, as a well-known phytochemical, can inhibit EMT/metastasis through various mechanisms and pathways in human tumors. Curcumin can exert chemo-preventive effects by inhibition and reversal of the EMT process through both TGF-β-dependent (e.g. in hepatoma and retinal pigment epithelial cancer) and -independent (e.g. in oral cancer, colorectal cancer, pancreatic cancer, hepatocellular carcinoma, breast cancer, melanoma, prostate cancer, bladder cancer, thyroid cancer and lung cancer) pathways. Curcumin can also mitigate chemoresistance through EMT suppression and promotion of the antiproliferative effects of conventional chemotherapeutics. Therefore, curcumin has the potential to be used as a novel adjunctive agent to prevent tumor metastasis, which may at least partly be attributed to its hampering of the EMT process.

The Brain And Memory
Herbal Remedies Home, May 2019
Curcumin has been linked to a lower dementia risk numerous times before. According to a 2009 study done by researchers from Duke University, it causes brain changes and reverses some of the effects of Alzheimer’s disease. Namely, it targets the amyloid plaques, which are considered to be one of the main causes of brain damage. The researcher Murali Doraiswamy said: “There is very solid evidence that curcumin binds to plaques, and basic research on animals engineered to produce human amyloid plaques has shown benefits. You can modify a mouse so that at about 12 months its brain is riddled with plaques. If you feed this rat a curcumin-rich diet, it dissolves these plaques. The same diet prevented younger mice from forming new plaques.” The active ingredient of turmeric, curcumin, is responsible for most of its medicinal and healing powers, since it is full of antioxidants and offers extremely powerful anti-inflammatory properties. According to Dr. Josh Axe, DC, DMN, CNS: “Arguably, the most powerful aspect of curcumin is its ability to control inflammation. The journal Oncogene published the results of a study that evaluated several anti-inflammatory compounds and found that aspirin and ibuprofen, two of the most common NSAIDs (non-steroidal anti-inflammatory drugs) are least effective, while curcumin is among the most effective anti-inflammatory compounds in the world. This news should have reached every household in the world after the study was conducted because inflammation is at the root of most diseases. Increasingly common diseases today — such as cancer, ulcerative colitis, arthritis, high cholesterol, and chronic pain — are all associated with inflammation. The anti-inflammatory effects of curcumin have also been studied as a possible treatment for Alzheimer’s disease. “ Moreover, this amazing spice improves health in a thousand other ways, cleanses the blood, prevents premature aging, detoxifies the liver, prevents free radical damage, improves skin health, and much more. Also, a series of 2013 studies done at the University of Tsukuba in Japan showed that curcumin improved two measures of cardiovascular health as much as aerobic exercise did. Also, numerous studies have confirmed that turmeric and curcumin will help you soothe arthritis, reduce body fat, prevent cancer, and improve cancer prognosis. Its anti-cancer activity has been studied and confirmed by numerous studies. Dr.Mercola reports: “ Curcumin actually has the most evidence-based literature supporting its use against cancer of any other nutrient, including vitamin D! As noted by Dr. William LaValley, curcumin is unique in that it appears to be universally useful for just about every type of cancer. This is odd, considering the fact that cancer consists of a wide variety of different molecular pathologies. One reason for this universal anti-cancer proclivity is curcumin’s ability to affect multiple molecular targets, via multiple pathways. Once it gets into a cell, it affects more than 100 different molecular pathways. And, as explained by Dr. LaValley, whether the curcumin molecule causes an increase in activity of a particular molecular target, or decrease/inhibition of activity, studies repeatedly show that the end result is a potent anti-cancer activity. Moreover, curcumin is non-toxic and does not adversely affect healthy cells, suggesting it selectively targets cancer cells—all of which are clear benefits in cancer treatment. Research has even shown that it works synergistically with certain chemotherapy drugs, enhancing the elimination of cancer cells.”

Effects of Curcumin on Microglial Cells
Neurotoxicity Research, May 2019
Curcumin is a phytochemical isolated from Curcuma longa. It is widely used in Asia and has many therapeutic properties, including antioxidant, anti-viral, anti-bacterial, anti-mutagenic, anti-amyloidogenic and anti-inflammatory, especially with respect to neuroinflammation and neurological disorders (NDs). Curcumin is a pleiotropic molecule that inhibits microglia transformation, inflammatory mediators and subsequent NDs. In this mini-review, we discuss the effects of curcumin on microglia and explore the underlying mechanisms.

Curcumin may help in some UC patients
MDedge.com May 2019
Curcumin was evaluated in a multicenter trial showing that, when added to maximal mesalamine, it may be helpful in avoiding an advance in therapy, with 54% achieving clinical remission at week 4 versus 0% of placebo-treated patients. Likewise, curcumin has shown “minimal harm” in mild ulcerative colitis and may help nudge patients toward disease control without having to resort to corticosteroids or other immunosuppressive therapy, Dr. Brant said.

Study highlights anti-tumor activity of curcumin on stomach cancer
Eureka Alert, May 2019
Curcumin is widely used to impart color and flavor to food, but scientists have discovered that this yellow powder derived from the roots of the turmeric plant (Curcuma longa) can also help prevent or combat stomach cancer. Curcumin influences histone modifications primarily by inhibiting HATs and HDACs to suppress cancer cell proliferation and induce apoptosis (programmed cell death). Garcinol, whose chemical structure resembles that of curcumin, inhibits HATs and helps prevent stomach cancer by neutralizing free radicals.

Best supplements for arthritis: Natural remedies to alleviate joint pain
Express, May 2019
Turmeric contains a chemical called curcumin, which can reduce pain and swelling by blocking inflammatory cytokines and enzymes. A clinical trial using a turmeric supplement in 2010 showed long-term improvement in pain and function in patients with osteoarthritis of the knee, A small study in 2012 using a curcumin product also showed more reduced joint pain and swelling in patients with active rheumatoid arthritis, when compared to diclofenac sodium.

Stop Different Types of Pain
Trending Posts, May 2019
Curcumin to stop the pain caused by inflammation. Curcumin is a natural proven remedy well known for its anti-inflammatory properties. One of the most popular spices of Asia is Turmeric and it can be widely used in medicines because its components contain anti-inflammatory properties. Comparisons between conventional medications and curcumin have been researched and it has been proved that curcumin is just as good as ibuprofen for relieving pain. Turmeric or curcumin capsules are being recommended by doctors for patients suffering from aches and sore joints.

Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity
Diabetology & Metabolic Syndrome, May 2019
Curcumin, a yellow pigment isolated from Curcuma longa rhizomes, has gained attention due to its beneficial effects in controlling the disturbances observed in diabetes mellitus. Treatment of diabetic rats with curcumin or metformin alone decreased the plasma levels of glucose, triacylglycerol, cholesterol, TBARS, and fluorescent AGEs, as well as increased the activity of PON 1. The combination of metformin with curcumin further decreased dyslipidemia and TBARS levels in diabetic rats, indicating synergy, and maintained the high levels of PON 1. These findings indicated that curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels. Therefore, it might be a promising strategy for combating diabetic complications, mainly the cardiovascular events.

The neuroprotective effects of curcumin
Drug Design, Development and Therapy, May 2019
The beneficial, neuroprotective effects of curcumin against ischemia-reperfusion injury have been demonstrated. In the present study, whether curcumin exerts neuroprotective effects associated with the inhibition of autophagy and hypoxia inducible factor-1α (HIF-1α) was investigated. In this study, curcumin decreased the death and apoptosis of cells, and inhibited autophagy and HIF-1α under OGD/R conditions, consistent with 3-MA treatment or HIF-1α downregulation. Moreover, inhibition of autophagy caused a decrease in HIF-1α, and the attenuation of HIF-1α induced autophagy suppression under OGD/R conditions. The results of this study showed that curcumin exerts neuroprotective effects against ischemia-reperfusion, which is associated with the regulation of the reciprocal function between autophagy and HIF-1α.

Curcumin supplementation mitigates NASH development
Physiological Reports, May 2019
Curcumin, a naturally occurring plant polyphenolic compound, may have beneficial effects in nonalcoholic steatohepatitis (NASH) development. Curcumin treatment (12WD vs. 12WD+C) reduced (P < 0.05) hepatocellular inflammation, steatosis, NAFLD Activity Scores, and serum markers of liver injury (AST, ALP). Moreover, curcumin treatment also increased hepatic pACC/ACC, ApoB100, and SOD1 protein, and decreased hepatic FGF‐21 levels; whereas, curcumin prevention increased hepatic glutathione levels. Both curcumin prevention and treatment reduced molecular markers of hepatic fibrosis (Col1a1 mRNA) and inflammation (TNF‐α, SPP1 mRNA). Curcumin supplementation beneficially altered the NASH phenotype in female Wistar rats, particularly the reversal of hepatocellular inflammation.

The study identifies the possible therapeutic effects of curcumin on gastric cancer
Onties.com May 2019
"We made a huge overview of the scientific literature on all nutrients and bioactive compounds with the potential to prevent or treat stomach cancer and found that curcumin is one of them," said Daniel Ciroz Calgano, a professor at UFPA.

What Are Nootropics? Your Guide To The Best Brain-Boosting Nutrients
Mind Body Green, May 2019
You may have 99 problems, but curcumin has probably already solved 98 of them—and you can add improved cognitive performance to that list. This compound in turmeric has been shown to improve working memory with consistent long-term supplementation. Curcumin can also increase BDNF, reduce oxidative stress, and inhibit inflammatory cytokines.

Daily dose of turmeric could boost memory, mood: study
Pan Armenian, May 2019
Curcumin, the compound that gives the spice its rich dark yellow colour, is widely established to have anti-inflammatory and antioxidant properties. The research, published in the American Journal of Geriatric Psychiatry, examined the effects of curcumin on memory performance in people without dementia, as well as its impact on people already suffering from Alzheimer’s disease. “Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimer’s disease and major depression,”. Memory tests showed that those taking curcumin improved by 28 percent over the 18 months and experienced mild improvements in mood. "These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years,” said Dr Small.

Study reveals turmeric is more effective at killing cancer cells than chemo or radiation
El Reportero, May 2019
One aspect of curcumin’s intelligent approach is its ability to downregulate interleukin-6. The over-expression of this cytokine has been linked to inflammation progressing to cancer, and curcumin stops it from being released and stimulating cancer stem cells. It also directly and indirectly downregulates interleukin-1, which plays a vital role in the growth of cancer cells, and interleukin-8, which stimulates the regrowth of tumor-forming cancer stem cells. Another way curcumin can fight cancer is by decreasing the binding of CXCR1 and CXCR2 and modulating pathways like the Wnt Signaling Pathway, the Notch Pathway, the FAK/AKT/FOXo3A Pathway, and the Hedgehog Pathways. If those terms are unfamiliar to you, you’re not alone – cancer is a complicated disease, but the bottom line is that curcumin targets deadly cancer stem cells in eight different and very powerful ways. Curcumin is a very efficient cancer fighter, targeting the most dangerous cells of all, cancer stem cells, without touching normal cells. Contrast this with chemotherapy, which damages the DNA of quickly-replicating cells while they’re vulnerable during the mitosis stage of cell division. It does this without determining if the cells are cancerous or completely healthy.

Healthy Options: Root Plants And Herbal Leaves For Stress And Anxiety Management
TG Daily, May 2019
Turmeric root, on the other hand, also has very promising benefits for the effective management of stress and anxiety disorders. Both animal studies and human studies conclude that the oral intake of curcumin can significantly prevent anxiety-like behavior and improve mobility.

Study: Curcumin, Resveratrol Possible Anti-Cancer Compounds
Whole Foods Magazine, May 2019
Curcumin can play a role in preventing stomach cancer, according to a new study from researchers at the Federal University of São Paulo (UNIFESP) and the Federal University of Pará (UFPA).

High blood pressure - best spices to prevent deadly hypertension symptoms
Express, May 2019
Turmeric’s active ingredient, curcumin, could play a role in lowering blood pressure, according to cardiologist Dr Stephen Sinatra.Curcumin is a powerful antioxidant the helps to break-up big clumps of platelets in the blood, he said. If you’d prefer to take curcumin as a supplement, aim for around 500mg in a single day. ou may not have heard of curcumin before, but you have probably heard of turmeric, the spice that is best known as an ingredient in Indian curry and yellow mustard. Turmeric has been my number one natural blood pressure reducer and cardiovascular spice for years, and its yellow colour comes from curcumin — a powerful antioxidant and anti-inflammatory compound that’s been found to reduce blood pressure by lowering the excess platelet aggregation that occurs in sticky, clot-forming blood.

Is the Curcumin in Turmeric More Effective Than Prozac for Depression?
Tmd.org May 2019
Curcumin is the main compound in the spice, turmeric. This spice is known for its bright yellow or orange color, flavorful taste, and is a great addition to curries. It is also well known in traditional medicine for its healing properties and has been used for centuries to heal many conditions. Curcumin possesses both anti-inflammatory and antioxidant properties. Beyond fighting common inflammatory-related conditions, such as arthritis and cancer, curcumin has been researched for its potential role in treating depression. One study found that curcumin therapy successfully reduces depressive symptoms when compared to the leading antidepressant medication, Prozac. What set curcumin apart was the fact that little to no side effects were reported. Antidepressants can cause any number of side effects including nausea, vomiting, blood pressure changes, dizziness, anxiety, and weight gain. With curcumin being more natural, these side effects can be avoided, and the depression itself can be successfully treated. Studies continue to research the effectiveness of curcumin on depression. With all this said, antidepressant medication is still preferred for good reasons, and these should be discussed with your physician. Do not stop taking prescribed medication before consulting with your doctor. The Natural Approach to Fighting Depression Curcumin is a strong antioxidant which means it scavenges and rids the body of harmful free radicals. The reduction of oxidative damage also reduces inflammation, and this can alleviate depressive symptoms. Studies have found a link between inflammation and depression but are not entirely which is the cause and which the result. The relationship does, however, tell us that by reducing inflammation, you can also reduce the symptoms of depression. Depression has also been scientifically linked to reduced production of BDNF (brain-derived neurotrophic factor), a growth hormone that impacts the function of your brain. Curcumin increases the presence of BDNF in the brain, which can lead to a reduction is depressive symptoms or a reduced risk of developing the disease. Curcumin has also been linked to increased production of the neurotransmitters serotonin and dopamine. Anxiety is another common mental disease that exists alongside depression in many cases. Curcumin has been found to increase the production of DHA, an essential omega-3 fatty acid. Deficiency in this omega-3 has been linked to increased anxiety, which can trigger or cause depression. By reducing anxious thoughts or behaviors, curcumin can also help reduce depression.

Why you should be adding turmeric daily to your life
Mustafa Mehar, May 2019
There have been over 50 clinical trials done on the health benefits of turmeric and curcumin and it seems there are only more coming our way. Below is a summary of some of the studies and their claims. The major health benefits of Turmeric 1. It plays a major role in cancer prevention, including myeloma, pancreatic, colon, breast, brain, blood, kidney, liver, pancreas and skin cancer. This is due to the fact that it can help prevent the initial processes that lead to mutations within our DNA. 2. It has major anti-inflammatory effects, according to a study which researched the efficacy of curcumin in the treatment for rheumatoid arthritis. It has been found to treat other inflammatory conditions effectively as well. 3. Turmeric plays a preventative role in the development of multiple diseases, such as lung disease and brain disease, and has been found to improve brain function. 4. It is beneficial for your cardiovascular health, supplementing daily with turmeric has been found to have as many benefits in improving our cell function in the arteries as one hour of aerobic exercise. 5. It is believed that turmeric may play a role in preventing Alzheimers disease. This condition is related to a build up of Amyloid-Plaques in the brain, and curcumin has been found to aid in removing these build ups. 6. Curcumin acts as a natural anti-depressant, where studies show it increases the brain’s serotonin and dopamine levels, as well as increasing brain-derived neurotrophic factor levels (BDNF). Low levels of BDNF has been associated with depression. 7. It offers anti-aging benefits. Oxidation and inflammation within the body are linked to aging and curcumin, a powerful anti-oxidant, potentially preventing these processes from occurring within the body. 8. Turmeric may also benefit your skin. The anti-inflammatory and antioxidant properties can aid with skin health, such as eczema or psoriasis.

Protective effects of curcumin in embryonic fibroblast cells
Journal of Biochemical and Molecular Toxicology, May 2019
The study indicated that curcumin might be a potential ameliorative antioxidant to protect the fibroblast cell toxicity induced by sodium arsenite.

Revealing the Effects of Curcumin on SH-SY5Y Neuronal Cells: A Combined Study from Cellular Viability, Morphology, and Biomechanics
Journal of Agricultural and Food Chemistry, May 2019
The present study provides insights into the effects of curcumin on neuronal cells from both biological and biophysical aspects, which can help more comprehensively understand the interactions between curcumin and SH-SY5Y cells.

Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study
Trials, May 2019
At days 14 and 28, patients receiving curcumin showed similar improvement in severity of pain and KOOS scale when compared with diclofenac, and the difference was not statistically significant. At day 7, the patients who received curcumin experienced a significantly greater reduction in the number of episodes of flatulence compared with diclofenac (P <0.01). At day 28, a weight-lowering effect (P <0.01) and anti-ulcer effect (P <0.01) of curcumin were observed. None of the patients required H2 blockers in the curcumin group, and 19 patients required H2 blockers in the diclofenac group (0% versus 28%, respectively; P <0.01). Adverse effects were significantly less in the curcumin group (13% versus 38% in the diclofenac group; P <0.01). Patient’s and physician’s global assessment of therapy was similar in the two treatment groups. Curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Curcumin can be an alternative treatment option in the patients with knee OA who are intolerant to the side effects of non-steroidal anti-inflammatory drugs.

How Curcumin Can Help with Memory and Conditions Like Dementia and Alzheimer’s
Life News, May 2019
The most beneficial compound found in turmeric is curcumin, and it can help support memory functions and contribute to a feeling of calmness and bring relief from mental stress or strain. It has also been shown to lessen fatigue as well as promote better heart health. Curcumin is also known to contribute to the increase of BDNF (a brain hormone), which then enhances the function of the brain’s neurons, encouraging growth and promoting strength. Also, one of the features of diseases such as dementia and Alzheimer’s is the buildup of amyloid-beta proteins or plaque. In some studies, curcumin was found to have the potential to obstruct the development of this plaque.

The major health benefits of Turmeric
Power Living, May 2019
Curcumin has major anti-inflammatory effects, according to a study which researched the efficacy of curcumin in the treatment for rheumatoid arthritis. It has been found to treat other inflammatory conditions effectively as well. It is beneficial for your cardiovascular health, supplementing daily with turmeric has been found to have as many benefits in improving our cell function in the arteries as one hour of aerobic exercise. It is believed that turmeric may play a role in preventing Alzheimers disease. This condition is related to a build up of Amyloid-Plaques in the brain, and curcumin has been found to aid in removing these build ups. Curcumin acts as a natural anti-depressant, where studies show it increases the brain’s serotonin and dopamine levels, as well as increasing brain-derived neurotrophic factor levels (BDNF). Low levels of BDNF has been associated with depression. It offers anti-aging benefits. Oxidation and inflammation within the body are linked to aging and curcumin, a powerful anti-oxidant, potentially preventing these processes from occurring within the body.

Remedies To Help Reduce Inflammation
Romper, May 2019
It's almost impossible to look at inflammatory remedies without mentioning this particular spice. "Turmeric has been used in India for thousands of years as a medicinal herb," says LA-based naturopath Dr. Saman Faramarzi. As it turns out, turmeric contains curcumin, which has anti-oxidant and anti-inflammatory properties, according to Foods. If you want to give this spice a try, then making turmeric milk (AKA golden milk) at home is a simple introduction, according to Elite Daily.

The Golden Spice: 5 Incredible Haldi Benefits That Would Take You By Surprise
NDTV, May 2019
Curcumin with its amazing anti-inflammatory abilities helps suppress chronic inflammation. Scientific research has shown a positive co-relation between curcumin and weight loss by preventing the growth of fat cells and it also protects against the negative impact of obesity on our health. Curcumin has been documented to improve insulin sensitivity, reducing elevated BP, and controlling triglyceride and cholesterol levels while improving HDL cholesterol. Antioxidant and anti-inflammatory activity of curcumin is the main reason of the health benefits of turmeric. It has been shown to reduce oxidative stress and increase the activity of our body's antioxidants. Curcumin has been found to have the strongest antioxidant effects when compared with other compounds.

Prevent Autoimmune Diseases
Medical Daily, May 2019
People are obsessed with turmeric supplements to fight pain and inflammation. Scientific evidence shows that curcumin, a pigment from turmeric root, regulates your immune system’s health and suppresses autoimmune diseases.

Anti-inflammatory foods that reduce pain
Baltimore Post Examiner, May 2019
Turmeric has a compound known as curcumin which has been found to be as effective as anti-inflammatory medications. Curcumin has powerful anti-inflammatory effects and antioxidants. It’s a better alternative because it has no side effects like the medication itself.

Best supplements for diabetes
Express, May 2019
Turmeric’s active ingredient, curcumin, could help to reduce insulin resistance, and subsequently protect against diabetes, said registered nurse David Spero. It improves insulin function, which allows more insulin to get into cells, he claimed. Adding turmeric to your diet could also lower your cholesterol and even prevent some types of cancer, added the nurse. “One diabetes medicine may lower blood sugar and cholesterol, protect your eyes and kidneys, relieve pain, prevent cancer, and improve your sex life. It also tastes good,” Spero wrote on Diabetes Self-Management. “This medicine is turmeric, made from the root Curcuma longa, a member of the ginger family. “Curcumin may also help treat aspects of diabetes, both type 1 and type 2.

Best supplements for arthritis
Expess, May 2019
Turmeric contains a chemical called curcumin, which can reduce pain and swelling by blocking inflammatory cytokines and enzymes. A clinical trial using a turmeric supplement in 2010 showed long-term improvement in pain and function in patients with osteoarthritis of the knee, A small study in 2012 using a curcumin product also showed more reduced joint pain and swelling in patients with active rheumatoid arthritis, when compared to diclofenac sodium.

Foods that Help Anxiety
Care2, May 2019
Turmeric has been shown in numerous studies to soothe both depression and anxiety. Not only do turmeric’s powerful phytochemicals do a stellar job of counteracting inflammation, but turmeric can help balance the chronically activated stress response that is associated with anxiety. Supplements of curcumin extract will be the most therapeutic source, but it definitely doesn’t hurt to enjoy a golden latte once in a while, either.

The One Supplement That Will Take Your Recovery To The Next Level
Mind Body Green, May 2019
Turmeric has proven its weight in (literal) gold with regards to fighting inflammation. That’s because its active compound, curcumin, is anti-inflammatory and has many preventative health benefits. And given that the root cause of many diseases is inflammation, turmeric has risen in popularity in both its whole, ground, and supplement form.

Reasons to Add Turmeric to Your Diet
IBC News, May 2019
Turmeric can help you reduce inflammation. The presence of curcumin in turmeric makes it a good remedy to fight inflammation. It is extremely good for arthritis patients. It can help arthritis patients treat inflammation naturally. There are several risk factors which can contribute to cancer. Various studies indicate that curcumin can reduce the growth of cancerous cells. According to the studies, turmeric consumption can help you reduce the risk of pancreatic cancer, prostate cancer and many others. Curcumin can also stimulate brain function and improve memory. According to studies, turmeric can help you boost brain power. It can also reduce the risk of Alzheimer’s disease and depression. It will also stimulate logical thinking.

More muscles in old age thanks to curcumin supplementation
Ergo-Log.com, April 2019
More muscles in old age thanks to curcumin supplementation. As you get older, your body loses more and more muscle mass. Initially the decay of your muscles is so slow that you hardly notice it, but every year the decay process runs a little faster than the year before. Supplementation with curcumin, the most important bioactive substance in turmeric, can block this process. This is evident from an animal study that will shortly appear in the International Journal of Molecular Sciences.

Natural food for the prevention of cancer
The Indian Talks, April 2019
Curcumin is a component of turmeric. Studies in mice have shown that curcumin prevents the occurrence of tumors caused by various carcinogenic factors. Angiogenesis is the process of forming capillaries. In the case of a cancer that may have occurred due to earlier DNA damage, it is a process that makes it possible to feed the cancer so that it can develop. In this way, micro-gas is transformed into a cancer capable of growing and attacking tissues. The purpose of curcumin is to inhibit the formation of new blood vessels that feed the cancer, depriving it of the possibility of taking nutrients and developing cancer.

Turmeric outperforms chemotherapies in treating cancer
Reports Health Care, April 2019
Curcumin is one of the active compounds in turmeric. It is responsible for most of the health-promoting effects offered by the spice. Curcumin, reportedly, benefits conditions like obesity, diabetes, cardiovascular diseases, neurological issues, cancer, and other chronic, inflammatory diseases. One research team analyzed a total of 19 test tube and five animal studies. They evaluated the ability of turmeric extracts to fight or prevent glioblastoma. The researchers found that curcumin inhibits the growth of cancer cells and induce cell death in certain subpopulations of glioblastoma tumors. Thus, it can serve as a potent therapeutic agent for treating cancer. The other study was published in the journal Nutrition and Cancer. It discovered the possibility to get a bioactive dose of curcumin into human glioblastoma cancer cells via oral delivery methods. Four days before surgical removal of brain tumors, the human volunteers for the study were given 70 milligrams of a curcuminoid combination three times in a day. During the surgery tumor and blood samples were collected for analyzing the curcuminoid concentrations. The tumors were found to have detectable levels of curcuminoids. This made the researchers conclude that oral treatments alter the energy metabolism of tumors. Many other studies also reveal the potent anti-cancer properties of curcumin. However, curcumin extracts are still not being used in cancer therapy. Researchers suggest the pharmaceutical industries to make use of this wonder spice for treating cancer. It can serve as a convenient, natural and safe treatment for the condition.

How To Use Turmeric To Fight Diabetes
Post News, April 2019
Hundreds of studies have been conducted on curcumin (the most important component of turmeric) and its effects on diabetes. The results about using turmeric for diabetes have been extremely encouraging. In this post, we talk about everything you possibly need to know about turmeric and turmeric for diabetes can be helpful. The curcumin in turmeric has been credited with most of its anti-diabetic effects. It was found to lower blood glucose levels and even fight inflammation – which is one severe effect of diabetes. One 2013 study conducted by the Beijing University of Chinese Medicine showed how curcumin could lower the glucose levels and help improve other diabetes-related conditions . Even turmeric extracts (often found in pharmacies) were found to make diabetes more manageable. And they also prevented other diabetes-related complications like nerve damage and cataracts.

Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury
Naunyn-Schmiedeberg's Archives of Pharmacology, April 2019
Amifostine, curcumin, and melatonin reduced the increases in serum urea and serum creatinine levels following cisplatin administration and reduced the levels of TNS, HPS, NF-κB/p65, 8-OHdG, and caspase-3 expressions (p < 0.05). ROS-scavenging antioxidants may be a promising means of preventing acute kidney disease in patients using cisplatin in the treatment of malignant tumors.

Nutrition: Get the protective power of phytonutrients
Duluth News Tribune, April 2019
Curcuminoids are phytonutrients found in turmeric root, which is a spice traditionally used in Indian cuisine. Curcumin offers anti-inflammatory benefits and may help prevent or treat colorectal cancer.

Health Benefits of Turmeric
Akhabar News, April 2019
Turmeric contains curcumin, a substance with powerful anti-inflammatory and antioxidant properties. Most studies used turmeric extracts that are standardized to include large amounts of curcumin. Chronic inflammation contributes to many common Western diseases. Curcumin can suppress many molecules known to play major roles in inflammation. Curcumin has powerful antioxidant effects. It neutralizes free radicals on its own but also stimulates your body’s own antioxidant enzymes. Curcumin boosts levels of the brain hormone BDNF, which increases the growth of new neurons and fights various degenerative processes in your brain. Curcumin leads to several changes on the molecular level that may help prevent and perhaps even treat cancer. Due to its many positive health effects, such as the potential to prevent heart disease, Alzheimer’s and cancer, curcumin may aid longevity.

Herbs & spices with the most powerful health benefits
New Times, April 2019
First and foremost, turmeric is an incredible inflammation fighter. It can even make a significant difference in individuals who suffer from rheumatic pain. This is because of constituent curcumin – its active constituent and yellow bioactive compound, lending turmeric its colour. Curcumin has a wide variety of biological interactions when consumed. Its anti-inflammatory benefits make it a good choice for healing leaky gut, improving digestion, and addressing autoimmune issues with inflammatory side effects. Due to curcumin’s anti-inflammatory properties, it has the ability to slow down inflammation-related ageing processes and diseases. Curcumin is also effective at increasing antioxidant capacity in the body. It’s one of the most concentrated antioxidant foods you can consume! This means an overall reduction of oxidative stress. Finally, curcumin can increase immunity with its antibacterial and anti-viral properties, protect against cancer and the development of tumours, and improve heart health.

Here's How Turmeric Could Help Keep Inflammation At Bay
NDTV, April 2019
"Curcumin has a medicinal effect comparable to drugs, such as hydrocortisone and phenylbutazone, and can be used to provide relief from rheumatoid arthritis, treat inflammatory bowel disease, protect against diabetes, and even avoid heart disease and stroke by preventing the build-up of plaque in the arteries," notes the book 'Healing Foods'.

Super foods every woman should include in her diet
The Hans India, April 2019
Turmeric may be the most effective nutritional supplement in existence. Many high-quality studies show that it has major benefits for your body and brain. Curcumin, a plant nutrient that gives turmeric its deep golden hue, has long been used in Eastern medicine to treat infections and help speed wound healing.

Turmeric: This must-have spice found in your kitchen is full of benefits
Times of India, April 2019
Turmeric comes from the root of Curcuma longa, a plant of the ginger family and contains compounds with medicinal properties. These compounds are called curcuminoids, the most important of which is curcumin. Numerous studies suggest that this spice is beneficial for both body and brain.

Foods to keep your brain, memory sharp
Daily Sabah, April 2019
Turmeric: With its active ingredient curcumin, turmeric is a strong yet natural antioxidant. This plant, which has been used for its medical benefits throughout history, helps your brain receive more oxygen, learn and process information easier.

Effects of turmeric and curcumin on oral mucositis: A systematic review
Phytotherapy Research, April 2019
The aim of this study was to evaluate the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy. Patients treated with turmeric/curcumin experienced reduced grade of mucositis, pain, erythema intensity, and ulcerative area. Current evidence suggests that topical application of turmeric or curcumin is effective in controlling signs and symptoms of oral mucositis. Thus, further investigation is required to confirm the promising effect of turmeric and curcumin in oral inflammatory lesions.

Effects of Prolonged Dietary Curcumin Exposure on Skeletal Muscle
International Journal of Molecular Sciences, April 2019
Curcumin is a phenolic compound shown to upregulate antioxidant defenses and directly quench RONS in vivo. Consumption of curcumin coupled with reduced food intake imparted beneficial effects on aged skeletal muscle. The benefit of curcumin on aging skeletal muscle should be explored further.

Curcumin and tetrahydrocurcumin induce cell death in Ara‐C‐resistant acute myeloid leukemia
Phytotherapy Research, April 2019
The effective use of curcumin as an anticancer agent has been demonstrated in clinical trials. Tetrahydrocurcumin, a major curcumin metabolite, exhibits pharmacological activities similar to those of curcumin. Curcumin induces cell death mainly through the apoptosis pathway, and tetrahydrocurcumin induces cell death mainly via an autophagy pathway in HL60 cells. The results demonstrated that curcumin and tetrahydrocurcumin induced cell death by apoptosis and autophagy, respectively, in Ara‐C‐resistant HL60 cells. Thus, curcumin and tetrahydrocurcumin have potential applications in the treatment of acute myeloid leukemia with Ara‐C resistance.

Curcumin inhibits the proliferation and invasion of MG-63 cells
OncoTargets and Therapy, April 2019
The aims of this study were to determine the effect of curcumin on osteosarcoma (OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic value of this pathway in OS. Curcumin-mediated inhibition of the proliferation and migration of MG-63 cells was associated with inactivation of JAK/STAT signaling.

Dietary curcumin enhances intestinal antioxidant capacity
Poultry Science, April 2019
The study investigated the effects of dietary curcumin supplementation on tissue distribution of curcumin and its metabolites, intestinal antioxidant capacity, and expression of detoxification-related genes in ducks. In conclusion, dietary supplementation with 200 to 800 mg/kg curcumin enhanced the accumulation of curcumin and its metabolites in jejunum as well as increasing the antioxidant capacity and detoxification potential, which play major roles in the protection of duck intestines against damage.

Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity
Environmental Science and Pollution Research, April 2019
Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4 weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and also histopathological and cytopathological changes of heart were studied. No significant changes in all studied parameters were seen between control, olive oil, curcumin, and taurine-treated groups. However, there were significant differences in levels of malondialdehyde and activities of antioxidant enzymes in BPA-exposed rats and some histo/cytopathological changes determined. In curcumin plus BPA-exposed and taurine plus BPA-exposed groups, we measured the preventive effects on some parameters but not exactly. As a result, curcumin and taurine significantly minimized BPA-induced cardiotoxicity in rats.

Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System
Molecular Neurobiology, March 2019
Curcumin, an active ingredient of turmeric, can affect all these pathways and exert neuroprotective activity culminating in the amelioration of I/R injury in the nervous system. In this review, we discuss the protective effects of curcumin against I/R injury in the nervous system and highlight the studies that have linked biological functions of curcumin and I/R injury improvement.

Top 5 Benefits of Turmeric for your Health
The Frisky, March 2019
Curcumin, a recognized anti-inflammatory, is the main component of turmeric. Curcumin is said to be as effective as drugstore anti-inflammatories like ibuprofen and aspirin. Curcumin present in turmeric boosts the body’s metabolism, reduces stress as an adaptogen, and enhances weight loss. All these factors combined increase the levels of good cholesterol in the body, and decrease the effects of bad cholesterol. It also helps in keeping blood sugar levels in check by stabilizing the glucose levels in the body. Curcumin boosts the production of a protein called BDNF, which is vital to the health of the brain. High BDNF levels generally result in better memory and mood.

Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity in the rat model
Journal of Cellular Biochemistry, March 2019
Curcumin is touted as a polyphenol phytocompound with appropriate cardioprotective properties. Curcumin was found to reduce oxidative status by reducing SOD and MDA contents ( P < 0.05). Gross and microscopic examinations revealed that the decrease of infarct area, inflammation response and collagen deposition in rats given ISO plus curcumin ( P < 0.05). We noted the superior effect of curcumin to reduce the number of apoptotic cardiomyocytes after 9 days. Data point the cardioprotective effect of curcumin to diminish the complication of infarction by the reduction of cell necrosis and apoptosis in a rat model of experimental infarction.

How to Stop Suffering from Chemo Brain
Care2, March 2019
The yellow-colored compound found in the curry ingredient turmeric, known as curcumin, offers more than delicious taste. It is a well-established brain-healer and memory booster. In a study published in the Journal of Psychopharmacology researchers found that in just one hour after taking curcumin supplements, study participants showed significant performance improvement on memory and attention tasks compared to the placebo group. Ideally choose a standardized extract of curcumin. I usually recommend 400 mg of curcumin three times daily for people suffering from brain disorders.

Curcumin reduces development of seizurelike events
Journal of Cellular Biochemistry, March 2019
The percentage of recorded CA1 neurons displaying SLEs was lower in curcumin‐treated slice cultures compared to vehicle‐treated slices (25.8% vs 72.5%), whereas rapamycin did not reduce SLE occurrence significantly (52%). Western blot for phosphorylated‐S6 (pS6) and phosphorylated S6K confirmed that rapamycin inhibited the mTOR pathway, whereas curcumin only lowered pS6 expression at one phosphorylation site. Real‐time quantitative polymerase chain reaction results indicated a trend toward lower expression of inflammatory markers IL‐1β and IL‐6 and transforming growth factor β after 3 weeks of treatment with rapamycin and curcumin compared to vehicle. Our results show that curcumin suppresses SLEs in the combined hippocampal‐entorhinal cortex slice culture model and suggest that its antiepileptogenic effects should be further investigated in experimental models of TLE.

Which herbs help reduce inflammation?
Granite Gazette, March 2019
Turmeric typically comes in the form of a yellow powder from the root of the turmeric plant. It contains a chemical called curcumin, which may have anti-inflammatory properties. Several have shown that turmeric can help reduce inflammation and discomfort in people with . It works by limiting the production of molecules called cytokines, which cause inflammation. Researchers continue to how curcumin affects inflammation in a range of other conditions, such as inflammatory bowel disease. Curcumin has the evidence base for its anti-inflammatory effects compared with other herbal remedies.

Effects of curcumin on hypoxia-inducible factor
Pharmacological Research Journal, March 2019
A growing body of evidence indicates that curcumin, a natural bioactive compound of turmeric root, significantly targets both HIF-1 subunits, but is more potent against HIF-1α. In this review, we have summarized the knowledge about the pharmacological effects of curcumin on HIF-1 and the related molecular mechanisms that may be effective candidates for the development of multi-targeted therapy for several human diseases.

Foods to unclog arteries
Femina, March 2019
While the anti-cancer benefits of turmeric have been well-documented, the key ingredient curcumin is also beneficial to heart health. This is primarily because of its anti-inflammatory benefits, which directly impacts arterial health, reducing the damage to arterial walls. Vitamin B6 can control damage caused to blood vessels.

Turmeric: A Secret Weapon to Lose Weight & Keep It Off
Dr. Cesar Lara, March 2019
Curcumin appears to modulate several cellular pathways that contribute to this ongoing, damaging process. Indeed, curcumin's anti-obesity effects may be in part due to its inflammation-reducing properties. One additional relevant mechanism of action not discussed in this study is curcumin's capacity to cause programmed cell death in white fat cells. This may contribute to decreasing the overall ability of the body to store unhealthy fat. Curcumin's Health Benefits Given the research above and the plethora of studies on distinct health conditions, it would be unethical not to use curcumin. Its safety profile is documented, and it has been time-tested for thousands of years in a wide range of cultures. In fact, curcumin has shown to be at least as effective for depression(8) as the antidepressant Prozac and is capable of preventing the progression of prediabetes to diabetes. It is also known to strengthen and improve your digestion(9) and support healthy liver function. Which Type of Curcumin (Turmeric Extract) is Best? When cooking, choose a pure turmeric powder rather than a curry powder. The curry powder may contain very little curcumin when compared to turmeric. You can also take curcumin in supplement form, which is a more convenient method to achieve the dosage needed for the health benefits discussed above.

Protective effects of curcumin on radioiodine‐induced salivary gland dysfunction in mice
Journal of Tissue Engineering and Regenerative Medicine, March 2019
Curcumin and RI + amifostine groups showed evidence of tissue remodeling, with a greater number of salivary epithelial cells (AQP‐5‐positive), SG ductal cells (CK18‐positive), endothelial cells (CD31‐positive), and myoepithelial cells (α‐SMA‐positive). RI + curcumin and RI + amifostine groups alleviated RI‐induced cell death, demonstrating anti‐apoptotic effect, compared to the RI group. Both SOD activity and the protein expression levels of SOD2 were higher in the RI + curcumin and RI + amifostine groups than in the RI group. Our results demonstrate that curcumin ameliorates RI‐induced SG dysfunction in mice.

Top 5 Health Benefits Of Turmeric And Its Compounds You Need To Know
NB Post Gazette, March 2019
Turmeric has anti-inflammatory properties because of the compound Curcumin. Moreover, it helps in cutting out all the bacterial infection that has covered the wound. Curcumin can effectively cure and improve endothelium. Moreover, oxidation and inflammation is a major partner of heart diseases. As mentioned earlier, this spice has compounds which have anti-inflammatory and antioxidative properties.

'Golden Elixir" made from turmeric
Press Republican, March 2019
Turmeric and especially its most active compound curcumin have many scientifically-proven health benefits, such as the potential to prevent heart disease, Alzheimer’s and cancer, according to a July 13, 2018 article on www.healthline.com It’s a potent anti-inflammatory and antioxidant and may also help improve symptoms of depression and arthritis.

Anti-Inflammatory Herbs
Care2, March 2019
If you’re thinking that turmeric seems to be good for just about everything, you’d be right. That’s because the curry ingredient contains a potent anti-inflammatory known as curcumin. In a study published in the Journal of Biological Chemistry researchers found that curcumin improved the healing of tendonitis, which involves inflammation of the tendons that help maintain our body’s structural integrity.

Advantages of Curcumin
Most Inside, March 2019
Curcumin is a naturally occurring antioxidant abundantly found in the popular spice turmeric that has been used since ages in cooking and Ayurvedic medicines for its incredible health benefits. Turmeric holds a pious place in Ayurvedic medicine and is applied on cuts and burns due to its anti-septic properties. Turmeric milk is extensively consumed in India as turmeric is studied to cure gastrointestinal discomfort, respiratory issues and helps in treating various bodily disorders. The Indian food culture places peculiar importance for spices and it is mainly used for making curry dishes as it renders distinct colour, flavour and nutrition to the food. Being such a valued spice on the health front, people across the world now understand the health benefits of Curcumin. Various medical researchers worldwide have investigated on how consuming turmeric or curcumin supplements can alleviate various health issues.

Know your mesonutrients
Times of India, March 2019
The world has recognised the medicinal use of curcumin and now curcumin milk, also known as turmeric latte, and it is part of café menus internationally. Curcumin is the active ingredient in turmeric, and when you look at all the research, it’s curcumin that delivers the anti-inflammatory and anti-ageing benefits that the super-spice is famed for. So, up your curcumin quotient.

Ayurvedic Herbs May Help Slow Down Ageing
NDTV, March 2019
Turmeric, or haldi, is one kitchen ingredient that is widely used in a number of dishes across the world. Curcumin, an essential compound found in turmeric, is shown to possess powerful anti-ageing effect. According to the book, 'Healing Foods' by DK Publishing House, "Curcumin reduces the build-up of the protein amyloid-b in the brain. Amyloid-b causes oxidative (free radical) damage and inflammation in the brain and is one of the main causes of Alzheimer's disease. Antioxidants in turmeric help to fight this free-radical damage."

Best supplements for arthritis: The Ayurveda plant supplement proven to support joints
Express, March 2019
Curcumin’s effect on reducing inflammation means it can also help protect your joints from wear and tear. “This includes easing symptoms of arthritis like joint movement and stiffness, according to a 2016 study in Journal of Medicinal Food.”

Best supplements for diabetes type 2 to avoid high blood sugar symptoms
Express, March 2019
Turmeric could help to lower your risk of high blood sugar, according to The Diabetes Council. Its active ingredient, curcumin, could help patients to improve their insulin sensitivity, it said. Diabetes patients that take turmeric supplements could significantly lower their blood sugar levels and insulin resistance, it added. “Curcumin is the yellowish/orangish powder which gives turmeric its beautiful colour in curry powder,” said The Diabetes Council. “It is widely used in many regions of the world for its pain-relieving features, improving digestion and liver functions. “A study discovered that curcumin decreases blood [sugar] levels and improved the sensitivity of insulin by reducing serum free fatty acids and increasing fatty acid oxidation.“Supplements containing curcumin significantly decreased fasting blood levels and insulin resistance in type 2 patients. “Use of curcumin also led to a significant decrease in serum, triglyceride fats, and an increase in lipoprotein lipase.”

Crusade against cancer: New treatment and nutrients you can rely on
The Heath Site, March 2019
Turmeric: It is rich in curcumin, a compound that is responsible for its yellow pigment. Being a powerful antioxidant, curcumin can potentially prevent chronic inflammation, responsible for some cancers. Just like ursolic acid, it also inhibits cancer cell growth. Curcumin is helpful in cancers pertaining to breast, ovary, uterus, kidney, bladder, brain, blood, colon and rectum, liver, pancreas, lung, etc. Add curcumin to your meals by sprinkling turmeric in your favourite dishes.

In vitro effect of curcumin on Schistosoma species viability
Experimental Parasitology, March 2019
Curcumin (CUR), the major phenolic compound present in rhizome of turmeric (Curcuma longa L.), has been traditionally used against various diseases including parasitic infections. CUR was found to affect the antigenicity of surface membrane molecules of S. haematobium, but not S. mansoni. Of importance, CUR significantly (P < 0.05 to < 0.0001) affected S. mansoni eggs hatchability and viability, a ground for its use in chemotherapy of schistosomiasis mansoni and japonicum because of its increased bioavailability in the gastrointestinal tract. The data together emphasize that CUR is a promising potential schistosomicidal drug.

20 Health benefits of Turmeric
InfoLoving.com February 2019
Turmeric (Curcuma longa) is the root of a plant that belongs to the same family as ginger. It is even less known in western cuisine, except as part of the spice mixture curry. The specific orange-yellow color is what gives curry powder its yellow color. There are 3 different yellow pigments (curcuminoids) in the turmeric root and these are also the substances that give turmeric its beneficial effects. These curcuminoids all work anti-oxidatively, anti-inflammatory, and are toxic to tumor cells. The most bioactive and tested substance of the three is curcumin that also has antiviral and antifungal properties. About 3% (in weight) of the turmeric root is curcumin. Health benefits of Turmeric is unlimited according to its uses. Most studies on the curative effect of turmeric are done with the extracted curcumin and high doses of 500 mg to 4 grams per day. To get that kind of quantities you have to use supplements with curcumin. This is especially true for people who are really sick or suffer from a specific condition.

Curcumin Antidiabetic and Anticancer Potential
Anticancer Research, February 2019
Curcumin and cinnamaldehyde have been previously reported to have antidiabetic and anticancer potentials. Curcumin and cinnamaldehyde decreased the activity of PTP1B, and had inhibitory effects on the viability of MCF-7 cancer cells. Curcumin had a significantly higher inhibitory effect than cinnamaldehyde. Conclusion: Curcumin can be considered a potential agent for the treatment of type-2 diabetes or cancer.

Does turmeric/curcumin supplementation improve nonalcoholic fatty liver disease?
Phytotherapy Research, February 2019
We performed a meta‐analysis to evaluate the efficacy of turmeric/curcumin supplementation on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with nonalcoholic fatty liver disease (NAFLD). We searched PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar up to November 20, 2018. Results from pooled analysis revealed that turmeric/curcumin supplementation reduced ALT (MD: −7.31 UL/L, 95% CI [−13.16, −1.47], p = 0.014) and AST (MD: −4.68 UL/L, 95% CI [−8.75 −0.60], p = 0.026). When RCTs stratified on the basis of their treatment duration, the significant reduction in serum concentrations of ALT and AST was observed only in studies lasting less than 12 weeks. This review suggests that turmeric/curcumin might have a favorable effect on serum concentrations of ALT and AST in patients with NAFLD.

Amazing Health Benefits of Curcumin/Turmeric Supplements
JottedLines.com, February 2019
Turmeric is biologically closely related to Ginger and is a very common ingredient in South Asian cuisines. Also called the Golden Spice, this lustrous golden-yellow spice is also treated as a herb whose properties are associated with purity and auspiciousness. One of the important compounds in Turmeric is Curcumin, which is credited for giving the spice its distinct color. Recent research has also revealed a gamut of health benefits that Curcumin offers. We all know that aging and debility are caused in part due to oxidative damage incurred by our cells. Free radicals that are ingested via the food we eat react with proteins, fatty acids & can even damage our DNA. Curcumin capsules essentially negate the action of free radicals on top of augmenting the body’s own antioxidant enzymes. This way, Curcumin/Turmeric deals a double blow to free radicals. Curcumin supplements are found to instigate the production of neurons in adults. Conventional wisdom had it that our brain does not create any more neurons once we are past childhood. But recent theories pertaining to neuroplasticity and neuroadaptibility have shown how our brains have amazing abilities to regenerate and restructure in constructive ways to enhance the survival potential of brain-injured patients. But this process does not happen in a vacuum. Under a regimen of certain nootropics like Curcumin/Turmeric, BDNF levels were observed to increase significantly. BDNF is in essence a growth hormone that acts in the central nervous system. Since BDNF is found to be subdued in people suffering from various psychiatric and neurological disorders, an increase in BDNF is expected to improve these conditions.

A randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients
Prostate, February 2019
The anti-cancer activities of curcumin are well-documented from preclinical studies using prostate cancer models. Our objective was to evaluate the anti-cancer activity of oral curcumin in patients with prostate cancer. The proportion of patients with PSA progression during the active curcumin treatment period (6 months) was significantly lower in the curcumin group than the placebo group (10.3% vs 30.2%, P = 0.0259). PSA elevation was suppressed with curcumin intake during the curcumin administration period. Curcumin at this dose was well tolerated and safe. Turmeric is an excellent aid for digestion because it already contains many of the minerals, vitamins, antioxidants, fiber, and anti-inflammatory compounds you need to "help acid production, muscle movement, and nutrient absorption to keep things moving like they should." The curcumin in turmeric: • helps the muscle walls of the intestines relax • balances gut flora in the colon • increases production of stomach mucous • eliminates cholesterol • prevents gas and bloating during digestion • relieves IBS symptoms. Taking curcumin can actually boost BDNF levels back up over time and even reverse the damage. Higher serotonin and dopamine may also be side effects of taking curcumin. A study actually found that people that took curcumin in addition to Prozac fared better than those just on Prozac or just taking curcumin for depression.

Curcumin: Can it slow cancer growth?
Mayo Clinic, February 2019
Curcumin, a substance found in the spice turmeric, has long been used in Asian medicine to treat a variety of maladies. Now some research suggests that curcumin may help prevent or treat cancer. Curcumin is thought to have antioxidant properties, which means it may decrease swelling and inflammation. It's being explored as a cancer treatment in part because inflammation appears to play a role in cancer. Laboratory and animal research suggests that curcumin may prevent cancer, slow the spread of cancer, make chemotherapy more effective and protect healthy cells from damage by radiation therapy. Curcumin is being studied for use in many types of cancer.

Curcumin a known anti inflammatory and antioxidant agent
International Journal of Molecular Biology: Open Access, February 2019
Curcumin is an active yellow color curcuminoid compound which is a naturally occurring plant pigment that is mostly found in turmeric and is native to Southeast Asia and India.1 It has an earthy odor and somewhat bitter taste and is mostly used in culinary.2 It is reported that pure turmeric residues contains about 3 percent of curcumin by weight.3 However curcumin is also available in the form of turmeric extract supplements which contains higher concentration of curcumin.4 It exhibits strong anti-inflammatory and antioxidant properties.5 In addition to that it is an excellent healing agent.6Health benefits of curcuminSome health benefits of curcumin are as follows:Relieves inflammationCurcumin is well known for its anti-inflammatory property that reduces chronic inflammation occurring in a number of medical conditions such as arthritis, bowel disease, heart disease, cancer, and diabetes etc.7 It has the ability to effectively block the function of those enzymes that contributes in inflammatory pathway.8Supports skin healthAntioxidant property of curcuminhelps in neutralizing free radicals that causes cell damage.9 In addition to that it accelerates healing of the wounds and collagen deposition in the skin.10 Curcumin is found to effective in treating psoriasis, dermatitis and scabies.11Lowers high blood sugarDiabetes associated symptoms such as impaired wound healing, increased thirst, vision loss, nerve damage, weight loss etc could be overcome by the use of curcumin which increases insulin secretion to reduce high glucose level in the blood.12,13Treatment of cancersCurcumin has an anti-cancerous effect on the growth of cancerous and tumour cells.14 It inhibits the function of cancer inducing growth factors and enzymes and blocks the signaling pathway hat is involved in the development of cancer in organs like breast, colon, pancreas and lungs.15,16Treatment of mental illnessesCurcumin aids in the treatment of depression and anxiety by reducing its associated symptoms.17 It increase the levels of omega-3 fatty acid that promotes the development of brain.18Prevents blood clottingCurcumin reduces platelet aggregation in the blood by inhibiting the formation of thromboxanes that causes clot formation in conditions like pulmonary embolism, stroke and deep vein thrombosis.19Reduces joint painRelieve rheumatoid arthritis related symptoms like stiffness, pain, swelling etc.20Regulates high cholesterol levelCurcumin boost cardiac health by lowering high cholesterol levels in blood.21Improves detoxificationCurcumin stimulates detoxification in order to protect the liver from diseases, allowing removal of toxins and cancer causing substances from the body.22Enhance brain functionCurcumin maintains cognitive function and prevent the risks of neurodegenerative diseases such as Parkinson’s and Alzheimer’s.23 It elevates the amount of brain derived neuro tropic factors which is involved in enhancing brain function, improving memory and reduces oxidative damage.24,2

Nootropic Supplements to Boost Memory & Brain Function
SD Entertainer, February 2019
Found in turmeric, curcumin has been shown to increase mental focus while reducing brain fog. The curcuminoids found in curcumin are effective at fighting oxidative stress caused by free radicals, boosting neural connections in the process.

Curcumin and Cancer
Cancer Therapy Advisor, February 2019
Curcumin inhibits cell proliferation and induces cell cycle arrest, apoptosis, and senescence — through various mechanisms, across multiple different types of cancer cell lines. Curcumin has been shown to decrease the expression of multiple different enzymes, transcription factors, inflammatory cytokines, growth factors, and other cell-signaling components that are important for cancer growth and progression. Curcumin downregulates the expression of the transcription factor NF-κB, which is commonly highly expressed by cancer cells and is known to promote the development of cancer, metastasis, and tumor growth.2 In addition, curcumin arrests the cell cycle at the G1/S or G2/M phases by inhibition of different cyclins. Curcumin also induces apoptosis through caspase-dependent pathways, and decreases the expression of antiapoptotic proteins. Curcumin has been evaluated in animal models of different cancer types.3 These studies have generally shown that curcumin has antiproliferative effects. For example, a mouse model of colorectal cancer (CRC) that was treated by intraperitoneal injection of curcumin or vehicle control demonstrated that curcumin prolonged life and inhibited tumor growth.4 These data also suggest that curcumin upregulated the miRNA miR-130a, which decreased the Wnt/β-catenin pathway and led to prolonged survival. Studies in animal models of breast cancer demonstrated that curcumin also downregulates NF-κB, reduces metastasis, and inhibits angiogenic signaling resulting in decreased microvessel formation.5 Animal studies of pancreatic cancer have also demonstrated that curcumin inhibits tumor growth, suppresses proliferation, and reduces angiogenesis.

A powerful antioxidant: Curcumin protects your heart from damage caused by diabetes and smoking
Plant Medicine, February 2019
To protect your heart from damage caused by diabetes and smoking, take curcumin supplements. A study published in the African Journal of Traditional, Complementary and Alternative Medicines found that curcumin protects the heart from the combined oxidative stress induced by diabetes and nicotine. In the study, researchers from King Saud University in Saudi Arabia assessed the ability of curcumin to ameliorate the combined oxidative stress induced by diabetes and smoking which can cause diabetic cardiomyopathy. Diabetes and cigarette smoking, which both cause oxidative stress, are primary factors that cause cardiovascular diseases. Curcumin is known to have protective effects against hyperglycemia-induced oxidative stress. When curcumin was administered, it inhibited the diabetic and nicotine-induced oxidative stress, which was seen by the normalization of the plasma cardiac marker troponin I and CK-MB. Based on these findings, the researchers concluded that curcumin has a protective effect on heart tissues against the combined oxidative stress induced by diabetes and nicotine. Curcumin can also keep the heart healthy and protect it from diseases by improving the function of the endothelium or blood vessel lining. According to Healthline, this improvement in the blood vessel lining can significantly reduce the risk of endothelial dysfunction, which is a primary risk factor of heart disease. It prevents the endothelium from regulating blood pressure and blood clotting properly. Many other studies have confirmed this beneficial effect of curcumin. One study even suggested that curcumin is as effective as exercise in this respect. Another study suggested daily supplementation of curcumin can improve heart health by improving cholesterol levels and reducing inflammation. This, in turn, may prevent the onset of atherosclerosis, which is a disease in which plaque builds up inside the arteries.

Spice may protect against breast cancer
MiceTimes, February 2019
Studies have shown that curcumin (the main chemical component of turmeric) has a number of valuable properties. In particular, curcumin can play a supportive role in the prevention of Alzheimer’s disease – it starts the process of protein production, which is struggling with brain damage by free radicals. In addition, it was revealed that curcumin can help in the treatment of skin cancer. The study, conducted by researchers from the cancer Center to them. Andersen at Texas a & m University (USA), curcumin was administered in the affected melanoma cell line, stimulated the destruction of malignant cells in tumors. There is also reason to believe that curcumin prevents the development of breast cancer. Expressive about this show in particular, experiments on mice conducted in the same the University of Texas. Now scientists are actively exploring other potential therapeutic properties of curcumin, in particular, for the treatment of multiple myeloma and pancreatic cancer, and the prevention of oral cancer.

Which herbs help reduce inflammation?
Medical News Today, February 2019
Turmeric typically comes in the form of a yellow powder from the root of the turmeric plant. It contains a chemical called curcumin, which may have anti-inflammatory properties. Several studies have shown that turmeric can help reduce inflammation and discomfort in people with arthritis. It works by limiting the production of molecules called cytokines, which cause inflammation. Researchers continue to investigate how curcumin affects inflammation in a range of other conditions, such as inflammatory bowel disease. Curcumin has the most substantial evidence base for its anti-inflammatory effects compared with other herbal remedies.

Turmeric helps prevent diabetes
Orissa Post, February 2019
Curcumin which is a component of turmeric helps prevent fatty deposits in blood vessels and development of fat tissues. So, adding turmeric in diet helps one maintain a healthy weight. Turmeric also promotes healthy bones by decreasing loss of bone minerals in the body.

Curcumin shows heart health benefits by ‘multiple mechanisms’
Nutra Ingredients, February 2019
In addition to the total and LDL cholesterol reductions, the researchers noted that HDL cholesterol was unaffected by curcumin addition to the diet. “These results support our hypothesis and indicate that curcumin may prevent the progression of atherosclerosis by reducing lipid accumulation. It appears that curcumin may prevent the progression of atherosclerosis by reducing lipid accumulation on the aortic endothelium.

Can curcumin improve exercise performance in those with heart failure?
Medical News Bulletin, February 2019
Curcumin administration restored muscle force and prevented rapid fatigue. Finally, the authors demonstrated that the positive effects of curcumin on CHF mice were attributed to improved Nrf2 signaling and not due to improved cardiac function. In conclusion, the data reaffirmed the authors’ hypothesis that impaired Nrf2 signaling in skeletal muscle of CHF mice contributes to exercise intolerance. More specifically, impaired Nrf2 signaling prevents the skeletal muscle from defending itself against CHF-associated oxidative stress, which likely affects skeletal muscle performance and reduces exercise capacity. These findings were further strengthened by the notion that curcumin, a Nrf2 signaling promoter, improved exercise capacity in mice with chronic failure without noticeable improvements in heart function and blood flow. Collectively, the authors found that targeting the Nrf2 signaling pathway may improve exercise capacity and overall quality of life in patients with chronic heart failure.

Can ginger, turmeric and lemon juice reduce blood sugar?
Legit.ng February 2019
The component of the popular curry spice, turmeric, also can help to lower the high index to normal blood sugar level. Curcumin, polyphenol and antioxidants play a vital role in this process. They reduce the amount of glucose in blood by slowing down its formation the liver.

Diabetes mellitus: Blood sugar-lowering ginger + other root vegetables for type 2 diabetes
The Health Site, February 2019
Turmeric root: Curcumin, found in turmeric exerts helps moderate insulin levels and enhance the efficacy of anti-diabetic drugs. Antioxidant-rich turmeric fights free radicals and reduces insulin resistance in the body. A study conducted by Department of Pediatrics, Louisiana State University Health Sciences Center revealed that curcumin present in turmeric prevents protein glycosylation (where the protein molecule is altered) and lipid peroxidation (oxidative degradation of lipids), thereby increasing the person’s sensitivity to lower blood sugar levels.

Three lesser known facts of turmeric
Baltimore Post Examiner, February 2019
Turmeric is an anti-inflammatory- The active ingredient in turmeric is something call curcumin, which is known for fighting inflammation and being full of antioxidants. The curcumin in turmeric fights inflammation at the molecular level, blocking a molecule called NF-kB, which is linked to many different inflammatory diseases like arthritis and IBD. 2. It helps with depression - Taking curcumin can actually boost BDNF levels back up over time and even reverse the damage. Higher serotonin and dopamine may also be side effects of taking curcumin. 3. Turmeric helps with digestion - Turmeric is an excellent aid for digestion because it already contains many of the minerals, vitamins, antioxidants, fiber, and anti-inflammatory compounds you need to "help acid production. The curcumin in turmeric has many benefits which includes the muscle walls of the intestines relax, balances gut flora in the colon increases production of stomach mucous, eliminates cholesterol, prevents gas and bloating during digestion and relieves IBS symptoms.

Foods that can boost your brain power
Savannah Now, February 2019
This spice, commonly found in Indian food, turns out to have an almost endless list of health benefits. It has been tied to improving gastrointestinal issues, and reducing the chances of getting heart disease, cancer and Alzheimer’s. Turmeric has also been found to reduce inflammation, primarily due to a compound in it called curcumin. Diseases like depression and Alzheimer’s have been linked to lower levels of brain-derived neurotrophic factor (BDNF), a type of growth hormone that helps with the formation of new neural connections in the brain. Turns out curcumin has been found to increase brain levels of BDNF. So by adding turmeric to soups and other dishes, you’ll be delaying or even reversing the effects of declining brain function.

Inhibition mechanism of cathepsin B by curcumin molecule: a DFT study
Theoretical Chemistry, February 2019
One of the natural compounds named curcumin has a well-documented history of medicine in India, which is currently in clinical trials for the treatment of various cancers. However, the inhibition mechanism of the curcumin molecule is not yet clear. In this present study, the inhibition of cathepsin B by the curcumin has been studied by quantum chemical methods using DFT method at M062X/6-31 + g(d,p)//B3LYP/6-31g(d) level of theory to obtain a complete picture of possible reaction paths. Based on the obtained results, the Cys29 can undergo nucleophilic attack at any one of the four reactive sites of the curcumin. The low activation energy 1.43 kcal/mol along with low negative reaction energy − 6.82 kcal/mol suggests that attack of Cys29 at C63 atom is the most feasible reaction path. These results suggest that curcumin can be used to develop less toxic cathepsin B inhibitors for the treatment of cancer disease.

Science confirms turmeric as effective as 14 drugs
Health Nut News, February 2019
If ever there were an herb that puts existential fear into the bottom line of pharmaceutical companies, its turmeric.

Are mesonutrients the new macronutrients?
Femina, February 2019
Mesonutrients are the active compounds that are present in each food, which are responsible for good health. Typically found in foods that are classified as superfoods, it is not just important to eat these foods – it is important to eat them the right way, so as to obtain the maximum benefits of the mesonutrients. One of the key mesonutrients is a staple in the Indian kitchen – turmeric. It has over 200 active compounds, and the key compound to watch out for is curcumin, which has anti-cancer and anti-inflammatory benefits.

The Unsung Benefits of Turmeric... and Why You Should Use It
Women.com, February 2019
The active ingredient in turmeric is something call curcumin, which is known for fighting inflammation and being full of antioxidants. The curcumin in turmeric fights inflammation at the molecular level, blocking a molecule called NF-kB, which is linked to many different inflammatory diseases like arthritis and IBD. Studies have found turmeric to be just as effective as medication but without the side effects that many anti-inflammatory medications have. In fact, one study found of rheumatoid arthritis found 500 mg a day of curcumin was more beneficial than diclofenac, an anti-inflammatory drug.

Impact of curcumin on energy metabolism in HIV infection: A case study.
Phytother Res, February 2019
Curcumin is a natural bioactive compound, which interacts with molecular targets and holds important metabolic properties. Oral curcumin supplementation can positively modulate the energy metabolism of people living with HIV/AIDS using the ART.

Efficacy of curcumin for management of oral submucous fibrosis: a systematic review of randomized clinical trials
Science Direct, February 2019
Six clinical trials comprising 298 patients were included. All studies found curcumin to be effective in the management of OSF. Three studies found significantly higher improvement in burning sensation in the curcumin group compared to controls, whereas three studies found comparable results. With regards to clinical signs, two studies showed better improvement in mouth opening in the curcumin group; three studies reported no differences in effectiveness; and only one study found curcumin to be inferior to conventional therapy. The available evidence remains inconclusive but suggests that curcumin is a promising effective treatment option for the management of patients with OSF. Further well-designed clinical trials with large sample sizes and adequate follow-up periods are highly warranted.

Curcumin improves the effect of a reduced insulin dose on glycemic control and oxidative stress in streptozotocin‐diabetic rats
Phytotherapy Research, February 2019
Isolated treatments using curcumin or insulin in a reduced dose (1 U/day) decreased glycemia, dyslipidemia, and biomarkers of liver and kidney damage and increased the activity of hepatic antioxidants (superoxide dismutase and glutathione peroxidase), however, only to a lesser extent than 4‐U/day insulin, without improvements in catalase activity or plasma lipid peroxidation. Decreases in glycemia, dyslipidemia, and tissue damage markers were more evident in the curcumin + 1‐U/day insulin treatment than those seen in isolated treatments. The activity of hepatic antioxidants, including catalase, was further increased, and biomarkers of oxidative damage were decreased. Curcumin with a reduced insulin dose appears to be a promising strategy for combating the complications associated with diabetes and oxidative stress.

Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis
Oxidative Medicine and Cellular Longevity, February 2019
Curcumin could significantly suppress the HSC-induced effects in HCC and could abrogate ROS and HIF-1α expression in HCC. HIF-1α or connective tissue growth factor (CTGF) knockdown could abolish the aforementioned curcumin affection. Moreover, CTGF is a downstream gene of HIF-1α. In addition, nuclear factor E2-related factor 2 (Nrf2) and glutathione (GSH) are involved in curcumin protection of HCC. These data indicate that curcumin may induce ROS scavenging by upregulating Nrf2 and GSH, thus inhibiting HIF-1α stabilization to suppress CTGF expression to exhibit its protection on HCC. Curcumin has a promising therapeutic effect on HCC. CTGF is responsible for curcumin-induced protection in HCC.

Curcumin ameliorates glyoxylate-induced calcium oxalate deposition and renal injuries in mice
Sciene Direct, February 2019
Curcumin, the predominant active component of turmeric, has been shown to have pleiotropic biological and pharmacological properties, such as antioxidant, anti-inflammatory and antifibrotic effects. Curcumin could significantly alleviate CaOx crystal deposition in the mouse kidney and the concurrent renal tissue injury. The underlying mechanism involved the combination of antioxidant, anti-apoptotic, inhibiting autophagy, anti-inflammatory, and antifibrotic activity and the ability to decrease expression of OPN and CD44 through the Nrf2 signaling pathway. The pleiotropic antilithic properties, combined with the minimal side effects, make curcumin a good potential choice to prevent and treat new or recurrent nephrolithiasis.

Curcumin supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes
Lipids in Health and Disease, February 2019
nsulin sensitivity was significantly improved in the CC supplemented group (32.7 ± 10.3%) compared to PL (P = 0.009). FO and CC-Curcumin tended to improve insulin sensitivity by 14.6 ± 8.5% and 8.8 ± 7.7% respectively, but the difference did not reach significance. Triglyceride levels were further increased in the PL (26.9 ± 7.4%), however, CC and CC-Curcumin supplementation reduced the triglycerides, Curcumin resulted in the greatest reduction in triglycerides (− 16.4 ± 4.5%, P < 0.001). Conclusion Reduction in insulin resistance and triglycerides by curcumin and LCn-3PUFA appears to be attractive strategies for lowering the risk of developing T2D

Curcumin attenuates adhesion molecules and matrix metalloproteinase expression in hypercholesterolemic rabbits
Science Direct, February 2019
Curcumin, the yellow substance found in turmeric, possesses antioxidant, anti-inflammation, anticancer, and lipid-lowering properties. Curcumin reduced the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and oxidized low-density lipoprotein cholesterol in serum by 30.7%, 41.3%, 30.4%, and 66.9% (all P < .05), respectively, but did not affect high-density lipoprotein cholesterol levels. In addition, curcumin attenuated HCD-induced CD36 expression, circulating inflammatory cytokines, and soluble adhesive molecule levels. Curcumin reduced the mRNA and protein expression of intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, and monocyte chemotactic protein-1, and it inhibited HCD-induced up-regulation of MMP-1, MMP-2, and MMP-9. Our results demonstrate that curcumin exerts an antiatherosclerotic effect, which is mediated by multiple mechanisms that include lowering serum lipids and oxidized low-density lipoprotein, thus modulating the proinflammatory cytokine levels and altering adhesion molecules and MMP gene expression.

4 Health Benefits Of Turmeric
Medical Daily, January 2019
"Turmeric has natural anti-inflammatory compounds called curcuminoids, and these curcuminoids have been associated with a positive effect on various diseases," said Anya Guy, a Mayo Clinic dietitian. Inflammation, as you may know, it the cause of several long-term health conditions. As a result, many studies have examined the potential of turmeric to ward off heart disease or reduce the risk of certain cancers. It is said that curcumin can help in reducing inflammation in pancreatic, fat and muscle cells. While most research on the link has involved rats, there was a clinical study in 2015 which saw 44 human participants experiencing a healthy weight loss over the course of two months. In a review published in 2016, participants from many trials reported that their osteoarthritis-related pain had reduced after taking curcumin. "Its efficacy in reducing pain, physical function, and quality of life among osteoarthritic patients has been demonstrated in many clinical trials," the authors wrote.

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation.
Scand J Med Sci Sports, January 2019
We examined the effect of curcumin (CUR) ingestion before or after exercise on changes in muscle damage and inflammatory responses after exercise. Increases in IL-8 were significantly reduced 12 h after exercise when curcumin was ingested before exercise. In Exp. 2, compared to the PLA subjects, MVC torque and ROM were higher 3-7 days and 2-7 days after exercise (P<0.05), respectively, whereas muscle soreness and CK activity were lower 3-6 days and 5-7 days after exercise (P<0.05), respectively, in curcumin subjects. Curcumin ingestion before exercise could attenuate acute inflammation, and after exercise could attenuate muscle damage and facilitate faster recovery.

6 Things That Happen To Your Body When You Eat Turmeric Every Day
Healthy Food House, January 2019
Turmeric is a potent anti-inflammatory, due to the presence of numerous anti-inflammatory compounds, such as curcumin, one of its most abundant compounds. After reviewing more than 700 studies, Dr. James Duke, a well-respected ethnobotanist, found that turmeric effectively outperformed many pharmaceutical drugs prescribed for various chronic, debilitative conditions, without causing any significant side effects. Curcumin eliminates plaque buildup in the arteries, and thus lowers the risk of atherosclerosis, which can cause a heart attack or stroke. It also lowers bad cholesterol known as LDL and prevents the formation of blood clots. Researchers have shown that curcumin triggers the production of bile in the gallbladder, and turmeric acts as a potential safeguard against remission in the case of ulcerative colitis. Turmeric has excellent anti-inflammatory properties, and rheumatoid arthritis patients who supplemented curcumin into their diets found that it led to a “reduction in tenderness” and a reduction in “disease activity”. Curcumin improves our ability to learn and process in different environments and prevents the development of neurodegenerative conditions, such as – dementia disorders and Alzheimer’s. Scientists have even proven that turmeric may aid in neuroplasticity, which is the development of new brain connections. According to Dr.Mercola: Curcumin is capable of crossing your blood-brain barrier, which is one factor that has led researchers to investigate its potential as a neuroprotective agent for neurological disorders such as Parkinson’s and Alzheimer’s disease. The potent antioxidant and anti-inflammatory properties of curcumin suggest it may also promote brain health in general. In the case of Alzheimer’s, recent animal research14 has discovered another bioactive ingredient in turmeric, besides curcumin, that adds to its neuroprotective effects. According to researchers at the American Cancer Society, curcumin“ interferes with several important molecular pathways involved in cancer development, growth, and spread.” Moreover, the US National Library of Medicine and National Institutes of Health published a study which showed that curcumin has potent cancer-fighting properties: “The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. Thus, an “old-age” disease such as cancer requires an “age-old” treatment.” “As noted by Dr. William LaValley—one of the leading natural medicine cancer physicians whom I’ve previously interviewed on this topic—curcumin is unique in that it appears to be universally useful for just about every type of cancer. This is odd, considering the fact that cancer consists of a wide variety of different molecular pathologies. One reason for this universal anti-cancer proclivity is curcumin’s ability to affect multiple molecular targets, via multiple pathways. Once it gets into a cell, it affects more than 100 different molecular pathways. And, as explained by Dr. LaValley, whether the curcumin molecule causes an increase in activity of a particular molecular target, or decrease/inhibition of activity, studies repeatedly show that the end result is a potent anti-cancer activity.”

How to live longer
Express, January 2019
Turmeric is packed with curcumin, which helps relieve long-term inflammation. Several studies have shown signs of inflammation are reduced in people who have taken capsules containing curcumin. Long-term inflammation can lead to health problems like inflammatory bowel disease, some cancers, dementia and arthritis. Turmeric may also help brain health, as curcumin may prevent amyloid-beta plaques forming in the brain - one of the hallmarks of Alzheimer’s disease - and may also help break them down. In addition, some lab-based studies have suggested curcumin may be able to kill cancer cells, particularly in the breast, bowel, stomach and skin, and prevent them from growing.

11 Health Benefits of Turmeric and Curcumin
HealthSky, January 2019
Research shows that curcumin binds to toxic metals and acts as an anti-inflammatory agent. Curcumin is also a strong antioxidant that captures and neutralizes free radicals (that are pathogenic particles). This brings all kinds of health benefits. Research shows that the curcumin in turmeric has a powerful anti-inflammatory effect. In some cases, it works better than an anti-inflammatory drug. The antioxidant effect of curcumin is very strong: animal research even shows that the antioxidant curcumin has a detoxifying effect in mercury poisoning. There are strong indications that the substance curcumin in yellow root has an inhibitory effect on the development of cancer cells. For example, research in rats has shown that curcumin can partially neutralize damage to cells in the liver, kidneys and brain, and thus prevent cancer in these organs. Research in humans shows that a curcumin supplement fights the pain better than the drug diclofenac. This is very beneficial, because the pain-relieving medication can cause serious side effects, while the natural substance curcumin does not damage the body. Alzheimer’s is caused by the fact that certain proteins (such as tau protein) clump in the brain, causing brain cells to die off. Studies in rats show that curcumin can prevent tau protein from coagulating. This keeps the brain healthy. Curcumin plays a major role in preventing and curing stomach ulcers, and supports a poorly functioning liver. Animal research shows that curcumin can reduce the risk of liver damage. Rats that were also given curcumin in their diet were less likely to suffer from liver disease than rats who did not. Research in rats shows that curcumin stimulates spatial memory. The rats given curcumin were significantly better at solving spatial puzzles than the rats that did not. In a study with 121 people undergoing cardiac surgery, participants were given 4 grams of curcumin or placebo, a few days before they were operated. The participants who received curcumin were 65% less likely to have a heart attack in the hospital. A recent article from 2017 looked at all the research done on turmeric and depression. This meta-analysis shows that the substance curcumin is indeed a safe and effective natural means to reduce depressive feelings. Curcumin can reduce the symptoms of depression, both on its own and in combination with other herbs. A very interesting outcome is that curcumin can strengthen the effect of antidepressants: the drugs for depression work better if curcumin is taken as a supplement. Turmeric capsules also contain much more of the active ingredient curcumin than the spice turmeric itself. In curcuma is about 3% curcumin, while that in turmeric capsules is 95%.

Curcumin attenuates collagen-induced inflammatory response through the "gut-brain axis"
J Neuroinflammation, January 2019
Previous studies have demonstrated that oral administration of curcumin exhibited an anti-arthritic effect despite its poor bioavailability. The present study aimed to explore whether the gut-brain axis is involved in the therapeutic effect of curcumin. Oral administration of curcumin restored the imbalance between the sympathetic and parasympathetic tones in CIA rats and increased ChAT activity and expression of ChAT and VAChT in the gut, brain, and synovium. Additionally, VGX eliminated the effects of curcumin on arthritis and ACh biosynthesis and transport. Electrophysiological data showed that curcumin markedly increased neuronal excitability of the vagus nerve. Furthermore, selective α7 nAChR antagonists abolished the effects of curcumin on CIA. Our results demonstrate that curcumin attenuates CIA through the "gut-brain axis" by modulating the function of the cholinergic system. These findings provide a novel approach for mechanistic studies of anti-arthritic compounds with low oral absorption and bioavailability.

This Is How Much Turmeric You Need to Reduce Inflammation
Readers Digest, January 2019
Curcumin—the main active component which gives turmeric its anti-inflammatory and antioxidant properties—only makes up 3 percent of dry turmeric, according to Ali Webster PhD, RD, Associate Director of Nutrition Communications, International Food Information Council Foundation. “Turmeric extracts or isolated curcumin found in dietary supplements are much higher in curcumin, so they’re more likely to have an impact on inflammation than the dried spice,” she says. So a dash of turmeric in the occasional recipe may not have lasting anti-inflammatory effects—unless a person consumes turmeric or curcumin supplements on a regular basis, too. Here are 10 proven ways to fight inflammation. Most research says that taking in at least one gram of curcumin per day is necessary for measurable anti-inflammatory effects, Webster says

Turmeric benefits: Use this yellow-colored powder for easing arthritis pain
The Heath Site, January 2019
Many studies have vouched that a key compound in turmeric known as ‘curcumin’ fight against inflammation and it is helpful in treating joint disorders like arthritis. It has the ability to improve joint health and reduce arthritis pain as well.

Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer
Oncology Report, January 2019
Effects of high glucose were counter-balanced by curcumin. EGF-induced proliferative, invasive and migratory abilities of BxPC-3 cells were abrogated by curcumin, LY 294002 and PD 98059. In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin. Taken together, the present study indicates that curcumin suppresses hyperglycemia-driven EGF-induced invasion and migration of pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway and its downstream signaling molecules including ERK and Akt. Curcumin is a potential anticancer agent for pancreatic cancer.

A Computational Study of the Driving Forces and Dynamics of Curcumin Binding to Amyloid-β Protofibrils
Journal of Physical Chemistry, January 2019
We have recently shown that curcumin exerts a neuroprotective effect against Aβ40 induced toxicity on cultured neuronal cells through two possible concerted pathways – ameliorating Aβ oligomer-induced toxicity and inducing the formation of nontoxic Aβ oligomers, both of which involve curcumin binding to Aβ oligomers. Our results show that curcumin binds to specific hydrophobic sites on the protofibril surface and that binding is generally associated with the concomitant complexation of curcumin into dimers, trimers, or tetramers. Curcumin also binds to the protofibril growth axis ends, but without complexation. Analysis of the energetics of the binding process revealed that curcumin complexation contributes in an additive fashion to curcumin - Aβ protofibril interactions. Favorable curcumin-protofibril binding is driven by a combination of hydrophobic interactions between curcumin and protofibril, curcumin self-aggregation, and solvation effects.

Benefits of Turmeric Curcumin for Inflammatory Orbital Pseudotumor
Care 2, January 2019
Curcumin, the yellow pigment in turmeric thought to be responsible in part for the spice’s anti-inflammatory effects. Eighteen patients were given curcumin alone, and every one improved, showing “efficacy…comparable to corticosteroid therapy,” but without any side effects. A larger, follow-up study was similarly encouraging. A total of 106 patients who had had a uveitis relapse in the year before starting curcumin were followed for a year. As you can see at 1:10 in my video in my video, only 19 had relapses in the year after starting curcumin. Altogether, the 106 patients had had multiple relapses—a total of 275 times—in the year before starting curcumin, but, in the year on curcumin, they had only 36 relapses. If turmeric curcumin works for mild eye inflammation and serious eye inflammation, what about really serious eye inflammation, like idiopathic inflammatory orbital pseudotumours. Let’s break that down: “Idiopathic” means doctors have no idea what causes it—from the Greek idios, as in idiot. “Orbital” refers to the bony cavity that houses our eyeball, and “pseudotumor,” as in not really a tumor. A lot has changed since the study was published in 2000. “[I]nflammatory orbital pseudotumour is now generally attributed to low-grade non-Hodgkin’s lymphoma,” so it does appear to be a form of cancer. Well, what can curcumin do about it? The researchers decided to look at curcumin because the available treatments are so toxic—steroids, radiation, and chemotherapy. In fact, all of the patients in the study were initially put on steroids but had to stop them because they either did not work or they had to be withdrawn because of complications. The researchers didn’t want to use radiation because they didn’t want to blind anyone. But they had to do something. All of the patients had so much swelling that they couldn’t move their eye as they normally would. If only there were some cheap, simple, and safe solution. Four out of the five patients who completed the study with curcumin therapy had a full response, defined as complete recovery with no residual signs or symptoms. In fact, complete regression of the eye dislocation and swelling occurred in all five out of five patients, but one patient continued to suffer some residual effects.

Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling.
Journal of Cellular Biochemisty, January 2019
Curcumin is an active ingredient possessing anti-inflammatory efficacy. Curcumin regulated the production of cytokines by suppressing the expression of inflammasome key components, including NLRP3, caspase-1. Further studies showed that the suppressive efficacy of curcumin on inflammasome was mediated by inhibiting MSU-induced NF-κB signaling activation. Intraperitoneal administration of curcumin could ameliorate symptoms of MSU-induced gouty arthritis, including the joint circumference, infiltration of neutrophils in knee joints, and production of IL-1β, TNF-α, and elastase. Western blot analysis revealed that the levels of NLRP3, procaspase-1, caspase-1, pro-IL-1β, and IL-1β were downregulated by curcumin in vivo. These results indicated that curcumin could effectively ameliorate MSU crystal-induced gouty arthritis through NLRP3 inflammasome mediation via inhibiting NF-κB signaling both in vitro and in vivo, suggesting a promising active ingredient for the prevention and treatment of gouty arthritis.

Impact of dietary supplements, diet on metabolic health explored in review
N
utritional Outlook, January 2019
Previous research indicates that curcumin (Curcuma longa), resveratrol, and quercetin, one of major flavonoids found in many plants, may exert a beneficial effect on the above metabolic parameters. Curcumin, specifically, has a polyphenolic structure with antioxidant and anti-inflammatory properties, according to a number of the studies analyzed. Inflammation and oxidative stress are key contributors to metabolic syndrome and NAFLD.

Curry spice boosts exercise performance
Science Daily, December 2018
New research suggests that curcumin, a main ingredient in curry, may improve exercise intolerance related to heart failure. The study is published ahead of print in the Journal of Applied Physiology. Curcumin, a chemical that comes from the turmeric plant, has been used as a traditional Asian medicine for centuries, primarily to treat gastrointestinal ailments and skin wounds. Studies increasingly suggest that the compound may prevent or limit muscle wasting associated with a number of health conditions, including heart failure. Researchers from the University of Nebraska Medical Center theorized that a reduction in the normal signaling of Nrf2, a protein that regulates the expression of antioxidant enzymes, may play a role in the impaired expression of antioxidant enzymes. They examined the effects of curcumin, which is known to promote activation of Nrf2, on a mouse model of heart failure with reduced ejection fraction. One group of mice with heart failure received daily doses of curcumin for 12 weeks, and another group did not receive treatment. The heart failure groups were compared to a control group of healthy mice that received curcumin and an untreated control group. The research team measured the exercise capacity of all the mice before and after curcumin treatment. The researchers also examined muscle fiber samples to assess enzyme expression levels. They found that expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin. In addition, both groups that received curcumin -- even the animals without heart failure -- had improved exercise capacity when compared with the untreated groups, suggesting the effects of curcumin on skeletal muscle is not exclusive to heart failure. "These data suggest that activation of Nrf2 in skeletal muscle may represent a novel therapeutic strategy to improve ... quality of life" in people with heart failure with reduced ejection fraction, the researchers wrote.

Curcumin Showing Promise In Alzheimer’s Research
World Health, December 2018
Curcumin/Turmeric has been used for thousands of years as both food and medicine. Growing bodies of research are showing it can help to fight Alzheimer’s disease, not only as a preventive but possibly as a cure. The potential of turmeric to help combat this debilitating disease cannot be ignored by mainstream medicine any longer, effects of this and others like it must be investigated more thoroughly; and experts are describing the effects of turmeric on Alzheimer’s patients as being remarkable. Much like most plant medicines turmeric has been largely ignored thanks to big pharma and the pharmaceutical industry’s all consuming grip on modern medicine and the blindly obedient public who follow by shunning those who dare think outside the sheepeople approved box. Scientists are beginning to wake up to the fact that medicinal plants do exist, and some even outperform big pharma’s concoctions. Recent research has shown that daily turmeric supplements taken for 12 weeks produced sizeable benefits in Alzheimer’s patients. Within one year patients began to recognize family members again according the the researchers. In all the study yielded impressive and promising results. Curcumin/turmeric has been studied for ability to help obliterate cancer, ward off neurodegenerative diseases and more, it is believed that curcumin extracts its benefits by enhancing processes associated with chemical signalling in cells and genes while boosting resistance to inflammation and stress. Curcumin/turmeric is also thought to help protect brain cells against premature aging, by binding to toxic proteins to help prevent forming of dangerous plaques while reducing oxidative stress and damage, lowering cholesterol, reducing inflammation signaling molecules, promoting clean up, and inducing protective mechanisms within the brain. University of Southern California researchers have also identified curcumin as prime source of improvement in Alzheimer’s patients via its antioxidant, anti-inflammatory and lipophilic action. Due to the various effects of curcumin including delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, and decreased beta amyloid plaques overall memory in Alzheimer’s patients has improved. The team has concluded that curcumin is a promising treatment for Alzheimer’s disease.

The natural polyphenol curcumin induces apoptosis in esophageal squamous cell cancer
Journal of Experimental & Clinical Cancer Research, December 2018
Curcumin is able to exert anti-tumor action through inhibiting the STAT3 signaling pathway. Giving its wide use in traditional medicines with low toxicity and few adverse reactions, it is conceivable that curcumin might be further explored as a unique STAT3 inhibitor for anti-cancer therapies.

New research on curcumin’s health benefits
Natural Products Insider, December 2018
Sports nutrition is an up-and-coming benefit sector for curcumin, especially in light of its potential to reduce inflammation and soreness caused by strenuous exercise. The antioxidant benefits of curcumin and its ability to modulate inflammatory pathways underscores its potential as an adjunct to recovery.1 In a recent randomized, double-blind, placebo-controlled study, curcumin was shown to be an effective supplement for recovery after strenuous exercise.2 An additional study also reported a reduction in 24-hour pain scores as well as increased muscle performance after a muscle-damaging exercise.3 Curcumin is also finding potential in heart health, where the effects of its anti-inflammatory properties are being researched. Recently, a highly bioavailable form of curcumin was studied in a healthy population to examine its role in endothelial function, which plays a critical role in cardiovascular health.4 Curcumin’s direct impact on healthy circulation was measured using flow mediated dilation (FMD). The randomized, double-blind, placebo-controlled study showed supplementing with 200 mg of curcumin had a clinically meaningful impact on potentially reducing cardiovascular disease by up to 50 percent in healthy individuals.

Curcumin and Vitamin D Treatment May Stabilize Disease in Patients with CLL and SLL
Cure Today, December 2018
In patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), high doses of curcumin and vitamin D could help stabilize the disease, according to new research presented at the American Society of Hematology’s (ASH) Annual Meeting in San Diego. Previous clinical studies have shown that curcumin, a chemical derived from turmeric, and vitamin D are both safe in high doses for patients with solid tumors. Additionally, the research presented at ASH notes that curcumin has been found to disrupt CLL cell interactions, induce cell death independent of DNA damage and upregulate vitamin D receptor levels in malignant cells. Given this, the researchers set out to examine whether the combination of curcumin and vitamin D could safely delay disease progression in patients with CLL/SLL. In their phase 2, open-label trial, the team enrolled a total of 35 previously untreated patients with asymptomatic, stage 0 to 2 CLL/SLL. The majority of patients (51 percent) were males with CLL (97 percent); 51 percent were stage 0, and 49 percent were stage 1. The median age was 60 years old. The 30 evaluable patients started out by receiving 8 grams of curcumin daily for one week, then added 10,000 IU of vitamin D3 orally. Both treatments were taken for up to six 4-week cycles. Patients received a median of five cycles, and the treatment was well tolerated. The most frequent side effects were diarrhea/gastrointestinal upset in 69 percent of patients, 14 percent of which experienced this at a grade 3. Eighteen patients completed all six cycles, while 10 withdrew consent, four discontinued treatment due to adverse effects and three patients’ disease progressed while on treatment. The primary endpoint of the study was the overall response rate (ORR), while secondary endpoints included event-free survival (EFS), time to next treatment overall survival (OS) and time to next treatment. Researchers also evaluated the levels of curcumin and vitamin D activity within CLL cells by using flow cytometry. The best response was stable disease in 28 of the 30 evaluable patients (93 percent). After a median follow up of 29 months, EFS was 72 percent, 74.1 percent had not started new CLL treatment, and OS was 100 percent. While no responses were seen, the majority of evaluable patients maintained stable disease while in treatment. The researchers concluded that because the combination of curcumin and high-dose vitamin D is safe and well-tolerated, additional extended follow up is now planned to examine how this treatment impacts the long-term progression of disease in patients with CLL/SLL.

Curcumin prevented human autocrine growth hormone in breast cancer cells
Molecular Biology Reports, December 2018
Curcumin (diferuloylmethane), a polyphenol derived from turmeric (Curcuma longa), has anti-proliferative, anti-carcinogenic, anti-hormonal effect via acting on PI3K/Akt, NF-κB and JAK/STAT signaling. This study aimed to investigate the role of NF-κB signaling and miR-182-96-183 cluster expression profile on autocrine GH-mediated curcumin resistance, which was prevented by time-dependent curcumin treatment in T47D breast cancer cells. Dose- and time-dependent effect of curcumin on T47D wt and GH+ breast cancer cells were evaluated by MTT cell viability and trypan blue assay. Apoptotic effect of curcumin was determined by PI and Annexin V/PI FACS flow analysis. Immunoblotting performed to investigate the effect of curcumin on PI3K/Akt/MAPK, NF-κB signaling. miR182-96-183 cluster expression profile was observed by qRT-PCR. Overexpression of GH triggered resistant profile against curcumin (20 µM) treatment for 24 h, but this resistance was accomplished following 48 h curcumin exposure. Concomitantly, forced GH induced invasion and metastasis through EMT and NF-κB activation were prevented by long-term curcumin exposure in T47D cells. Moreover, 48 h curcumin treatment prevented the autocrine GH-mediated miR-182-96-183 cluster expression stimulation in T47D cells. In consequence, curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-κB signaling and miR-182-96-183 cluster expression and induced apoptotic cell death by modulating Bcl-2 family members in T47D breast cancer cells.

Curcumin targets aggressive and lethal forms of cancer while leaving noncancerous cells unharmed
Natural News, November 2018
Curcumin, the most active constituent in turmeric, is a powerful antioxidant and is responsible for most of the spice’s magical health benefits. Studies have already shown, for example, that curcumin can cut the growth rate of prostate cancer tumor progression in half. Other studies have found that supplementing with curcumin can lead to a 36 percent decline in lung tumor size and a 40 percent reduction in colon tumor development. In a new study published in the Proceedings of the National Academy of Sciences, researchers used models to show how turmeric can inhibit the DYRK2 enzyme. With the help of x-ray crystallography, they obtained 3-D images that show curcumin binding to this enzyme atomically. You might be wondering why we should be excited about this. It turns out that inhibiting the DYRK2 enzyme stops protein complexes known as proteasomes that are involved in cancer development. This action interferes with the proliferation of cancer cells, reducing tumors and slowing the cancer’s growth. This is great news for sufferers of proteasome-addicted cancers, such as triple-negative breast cancer and multiple myeloma. These cancers depend on the proteasomes that curcumin inhibits for their survival. While pharmaceutical proteasome inhibitors do exist, they have the undesirable effect of also damaging noncancerous cells at the same time. Curcumin, on the other hand, does this without damaging any healthy cells. Moreover, it carries very few side effects and can get the job done in smaller dosages. Perhaps even more excitingly, this isn’t the only way that curcumin helps fight cancer. It can also stop the blood vessels that give tumors life from growing and developing, and it can turn off the genes that promote the development of tumors. At the same time, it can help your body’s immune system to find and destroy any malignant cells. In addition, it can stop the production of the adhesion molecules that enable cancer cells to stick to cell walls. It also protects cell DNA from incurring cancerous mutations from environmental toxins and radiation. In other words, curcumin takes a multi-pronged approach to fighting cancer, seemingly trying to stop it at every turn.

Curcumin Inhibits Age Related Vascular Changes
WorldHealth.net November 2018
This study investigated effects of long term use of curcumin on vascular aging and chronic inflammation which is the cause of arteriosclerotic disease. 8 week old C57BL/6J mice were fed high fat diets or curcumin mixed high fat diets until the animals reached 80 weeks of age. Expression of antioxidant enzymes, heme oxygenase-1, oxidative stress, vascular aging, and inflammatory changes in the aorta were examined. Oxidative stress increased with decreases in sirt1 expression in the aorta, followed by increased amounts of senescent cells and enhanced inflammation in the animals fed the high fat diets alone. In the animals fed curcumin mixed high fat diets heme oxygenase-1 was induced in the aorta with suppression of oxidative stress; sirt1 expression was shown in the aorta to remain at a level comparable to that of 8 week old mice with suppression of increased senescent cells and enhanced inflammation resolving issues associated with high fat diets. According to the researchers curcumin may be a food with prophylactic functions against arteriosclerotic diseases, helping to control weight gain, increases in blood glucose levels and blood cholesterol levels associated with long term consumption of high fat diets; as well as multifaceted benefits such as anti-cancer effects, anti-inflammatory action, and antioxidative action, along with various physiological activities in vivo.

Curcumin Targets Cancer Cells
WorldHealth.net November 2018
Curcumin is a powerful antioxidant that is attributed to most of the health benefits. It has been shown to cut growth rates of prostate cancer tumor progression by 50%; supplementation can lead to 36% decline in lung cancer tumor size, and 40% reduction in colon tumor development. In this study researchers used models to show how turmeric can inhibit DYRK2 enzymes using x-ray crystallography to obtain 3D images to demonstrate curcumin binding to this enzyme atomically. Inhibiting these enzymes stops proteasome protein complexes involved in cancer development, which interferes with cancer cell proliferation reducing and slowing cancer growth. Proteasome addicted cancer cells such as triple negative breast cancer and multiple myeloma depend on proteasomes for survival that curcumin inhibits. Pharmaceutical inhibitors do exist, but they also damage healthy cells along with the cancerous cells at the same time. Curcumin can do this while leaving healthy cells undisturbed, which is great news. Not only can curcumin target and help to fight cancer, it helps to stop blood vessels that give tumors life from growing and developing, and turns off genes that promote development of tumors. Curcumin also protects DNA from incurring cancerous mutations from radiation and environmental toxins. It would seem curcumin takes multipronged approaches to fighting cancer by trying to stop it at every turn.

Curcumin very effective senolytic affects
Scienceblog.com November 2018
Recent data suggest that curcumin, a phytochemical with cancer chemopreventive potential, might be useful in the treatment of several solid and hematological malignancies. Overall, this work shows that curcumin is capable of inducing topo−DNA complexes in cells with both topo I and topo II and increases the evidence suggesting that this dietary agent has potential to be tested in cancer chemotherapy.

This spice helps against tumors
BobrTimes.com November 2018
Curcumin has the property to engage in connection with a specific enzyme DYRK2 – this combined substance slows down the activity of cancer cells, preventing their rapid growth and uncontrolled reproduction in the body. Laboratory tests have shown that when curcumin is combined with medicinal substances for the treatment of specific varieties of tumors of blood, it greatly enhances their effectiveness and even reduces the side effects.

Curcumin Inhibits Age-Related Vascular Changes in Aged Mice Fed a High-Fat Diet
Nutrients, November 2018
Inhibiting the onset of arteriosclerotic disease, which has been increasing due to the westernized diet and aging, is a significant social challenge. Curcumin, a type of polyphenol, has anti-oxidative effects and anti-inflammatory action and is expected to treat and to have prophylactic effects on different diseases. In this study, we examined the effects of long-term administration of curcumin on vascular aging and chronic inflammation—the causes of arteriosclerotic disease. These results suggest that curcumin might be a food with a prophylactic function against arteriosclerotic disease.

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2
PNAS, November 2018
Curcumin, the active ingredient in Curcuma longa, has been in medicinal use since ancient times. Interestingly, curcumin synergizes with the therapeutic proteasome inhibitor carfilzomib to induce apoptosis in a variety of proteasome-addicted cancer cells, while this drug combination exhibits modest to no cytotoxicity to noncancerous cells. In a breast cancer xenograft model, curcumin treatment significantly reduces tumor burden in immunocompromised mice, showing a similar antitumor effect as CRISPR/Cas9-mediated DYRK2 depletion. These results reveal an unexpected role of curcumin in DYRK2-proteasome inhibition and provide a proof-of-concept that pharmacological manipulation of proteasome regulators may offer new opportunities for anticancer treatment.

Benefits of Golden Turmeric
Healthline.com October 2018
Research shows that ginger, cinnamon and curcumin — the active ingredient in turmeric — have potent anti-inflammatory properties (6, 7, 8).
Studies even suggest that the anti-inflammatory effects of curcumin are comparable to those of some pharmaceutical drugs with none of the side effects (9, 10). These anti-inflammatory effects may reduce joint pain from osteoarthritis and rheumatoid arthritis.For instance, one study in 45 people with rheumatoid arthritis found that 500 grams of curcumin daily reduced joint pain more than 50 grams of a common arthritis drug or a combination of curcumin and the drug (11). Similarly, in a 6-week study in 247 people with osteoarthritis, those given ginger extract experienced less pain and required less pain medication than those given a placebo (12). Studies show that curcumin may increase levels of brain-derived neurotrophic factor (BDNF). BDNF is a compound that helps your brain form new connections and promotes the growth of brain cells (13). Low levels of BDNF may be linked to brain disorders, including Alzheimer’s disease (14, 15). In a 6-week study, 60 individuals with major depressive disorders took either curcumin, an antidepressant or a combination. Those given only curcumin experienced similar improvements as those given antidepressants, while the combination group noticed the most benefits (23). Depression may also be linked to low levels of brain-derived neurotrophic factor (BDNF). As curcumin appears to boost levels of BDNF, it may have the potential to reduce symptoms of depression (24). curcumin may improve the function of your blood vessel linings — known as endothelial function. Proper endothelial function is important for a healthy heart (28). In one study, people undergoing heart surgery were given either 4 grams of curcumin or a placebo a few days before and after their surgery. Those given curcumin were 65% less likely to experience a heart attack during their hospital stay than people in the placebo group (29). Curcumin, the active ingredient in turmeric, may also kill cancerous cells and prevent the growth of new blood vessels in tumors, limiting their ability to spread (44, 45).

Health Benefits of Turmeric and Curcumin
Mommyish.com October 2018
Turmeric and curcumin are believed to be as effective, if not more effective, than the most powerful anti-inflammatory drugs. Curcumin can increase brain-derived neurotrophic factor (BDNF), a growth hormone that functions in your brain. Low levels of BDNF have been linked to brain diseases like Alzheimer’s and depression. Turmeric and curcumin may be effective at delaying some of those brain diseases, or even reversing them. Curcumin is a powerful antioxidant that can protect your body from free radicals, and boost your body’s own antioxidant enzymes. In addition to improving inflammation and oxidation, turmeric and curcumin improves the function of the endothelium, which is the lining of your blood vessels. Endothelial dysfunction is a major driving force behind heart disease, as it affects your body’s blood clotting and ability and blood pressure. In one of the most highly-regarded studies on curcumin, the group who received a curcumin supplement lowered their risk of heart attack by 65%. Several studies have shown that curcumin was more effective at managing the painful symptoms of arthritis than the strongest anti-inflammatory drugs. In an interesting controlled study, participants were put into three groups. One group took Prozac, one group took a curcumin supplement, and one group took both in conjunction. After six weeks, the group that took curcumin showed as much improvement as the group that took Prozac. The group that fared the best in the study was the one that took both.

10 Things That Happen When You Eat More Turmeric
Readers Digest, October 2018
We all know turmeric is an anti-inflammatory powerhouse, but do you know which parts of the body it can benefit the most?

Is it Time for a Curcumin-Based Mesothelioma Treatment?
Surviving Mesotheliom, October 2018
Yet another scientific study appears to confirm the power of the spice-derived compound curcumin as a weapon against malignant pleural mesothelioma. The Chinese researchers who conducted the latest study say the substance has the potential to be the basis of a whole new way of treating this aggressive asbestos cancer. This team tested curcumin on a line of mouse mesothelioma cells, both in the lab and in live animals, and published their promising results in the prestigious International Journal of Oncology. As a plant polyphenol, curcumin has powerful anti-inflammatory and antioxidant properties and has been the subject of numerous mesothelioma studies around the world in just the last three years. Curcumin appears to work in several ways, including disrupting mesothelioma cell DNA, inducing programmed cell death, and preventing the formation of a tumor-supporting blood supply (angiogenesis). Just as importantly — and in sharp contrast to other types of mesothelioma treatments — curcumin has very low toxicity. In the current study, Chinese researchers used a variety of sophisticated testing tools to assess the impact of curcumin on a mouse mesothelioma cell line. They applied the compound to cells in the lab and in mesothelioma tumors implanted under the skin of live mice. They found that curcumin exerted a range damaging effects on the mesothelioma cells including: Disruption of vital signaling pathways Induction of apoptosis Inhibition of blood vessel formation Prevention of proliferation signals The results prompted lead author Chengke Zhang of the Department of Thoracic Surgery at The Second Hospital of Shandong University to conclude, “Curcumin may be potent enough to be developed as a novel therapeutic agent for the treatment of malignant pleural mesothelioma.” A number of previous studies have also suggested that curcumin has merit as an alternative therapy for mesothelioma. A study conducted last year at the University of Rome found that mice infected with peritoneal mesothelioma lived longer when they were given curcumin. A few months later, French researchers used curcumin to shrink sarcomatoid tumors in lab rats. In 2015, researchers in Australia conducted the first experiments of curcumin on human mesothelioma cells and concluded that the compound could be a helpful supplement to standard treatment for certain mesothelioma patients. In another 2015 study, Italian researchers found that curcumin was even more effective against mesothelioma when delivered into cells via nanoparticles which overcame cells’ natural resistance to the compound. Curcumin is of particular interest to mesothelioma researchers because there are so few viable treatment options for this deadly cancer.

Curcumin Helping To Prevent Fluoride Induced Damage In The Brain
Worldhealth.net, October 2018
Adding supplementation of curcumin significantly reduced toxic effects of fluoride to close to normal levels by augmenting antioxidant defense via its scavenging properties, and provided evidence of having therapeutic roles against oxidative stress mediated neurodegeneration. This is not the only study to demonstrate the remarkable brain saving properties curcumin possesses; there are over 200 peer reviewed published studies indicating curcumin is a neuroprotective agent. When one takes into consideration the many chemical insults faced on a daily basis in the post industrial world, turmeric/curcumin may very well be one of the world’s most important herbs, which has over 800 evidence based health applications.

Curcumin, Commonly Found In Indian Food, Improves Memory, Mood, Attention
Studyfinds.com  September 2018
Those who took the curcumin performed better on the cognitive tests, showing better memory recall and attention spans compared to those who took the placebo. In fact, individuals in the curcumin group showed an average of 28 percent improvement on the memory test at 18 months. Thirty participants also agreed to undergo brain scans to test for levels of amyloid and tau — which are key markers for Alzheimer’s disease — at the beginning of the study and at the follow-up period. After 18 months, those who took curcumin showed much lower levels of the two proteins than those in the placebo group.

This Spice Can Protect Your Liver
Belmarra Health, September 2018
The latest research findings uncovered that curcumin may have the potential to protect the liver from non-alcoholic fatty liver disease (NAFLD) and may even be a form of treatment. In rat studies, researchers uncovered that curcumin reduced hepatocellular inflammation along with providing other benefits.

Role of Curcumin and Gallic acid as antioxidants
PLOS One, September 2018
Curcumin and/or Gallic acid alleviated the adverse effects caused by tramadol. In addition, patients should be advice to take Curcumin and/or Gallic acid prior to tramadol treatment to alleviate the hepatic and renal toxicities caused by tramadol.

Enhanced anticancer effects of low-dose curcumin with non-invasive pulsed electric field on PANC-1 cells
Dovepress, September 2018
A non-contact approach using low intensity electric field in a pulsed waveform could enhance the anticancer effect of low-dose curcumin on PANC-1 cells through triggering both extrinsic and intrinsic pathways. The findings highlight the potential of this alternative treatment, non-invasive electric field and curcumin, to increase therapeutic efficacy with minimum cytotoxicity and side effects, which may provide a new aspect of cancer treatment in combination of PEF and other anticancer agents.

Chemoprevention of inflammation-related colorectal cancer by curcumin- and maltodextrin-enriched dietetic formulation in animal model
Carcinogenesis, September 2018
Seventy were treated with azoxymethane (AOM)/dextran sulfate sodium and divided into two groups: 35 received standard diet and 35 enriched formulation (curcumin, boswellic acids, silymarin and maltodextrins). Our results are promising for a successful anti-inflammatory and chemopreventive effect of enriched formulation in CRC arising from inflamed tissue.

Benefits of the Golden Spice Herb: Turmeric
SD Entertainer, August 2018
Turmeric, used in traditional Chinese medicine, can also be an aid in the stagnation of blood or even epilepsy, due to its ability to lower blood pressure. These properties are aided by healing compounds curcuminoids, or Curcumin which is the active substance in turmeric. In the article Curcumin: A Review of It’s Effects on Human Health, Susan Hewlings and Douglas Kalman write, “Curcumin has been shown to improve systemic markers of oxidative stress. There is evidence that it can increase serum activities of antioxidants such as superoxide dismutase.” The possibilities are endless and this little spice that can help your body heal as well as be a special tool that can transform your overall health, allowing you to explore the options of natural remedies when it comes to your well-being.

This popular spice may prevent diabetes
Bobr Times, August 2018
Curcumin as antioxidant component of the plant has properties to normalize insulin production, thus preventing type II diabetes. According to them the action of curcumin is associated with the reduction of fat content in tissues – mice this effect was observed even though high-calorie foods. Preliminary research has also demonstrated anti-cancer properties of curcumin. Experts from Saint Louis University in Missouri it was found that part of the substance turmeric curcumin and silymarin do not allow cancer cells to divide and thus can help in the treatment and prevention of colon cancer.

Priyanka Chopra is Obsessed With Turmeric Because, Well, Who Isn’t?
Organic Authority, August 2018
Rich in bioflavonoids, beta-carotene, and vitamins C and A, as well as a host of other nutrients, its main claim to fame is the active compound curcumin, which may be responsible for many of the spices noted health benefits, including anticarcinogenic properties. A new study seemed to reaffirm the turmeric’s reputation as an anti-cancer fighter, in addition to being beneficial in the prevention of chronic disease and inflammatory conditions like rheumatoid arthritis, IBD and asthma.

Protect Against 'Evolving Stroke'
NewsMax, August 2018
One type of stroke event is “evolving stroke.” In these cases, the neurological damage — weakness, speech impairment — gradually gets worse after the first few days. When this happens, the penumbra neurons, instead of returning to normal, start dying off and expanding the damage. This can occur for a number of reasons, but most often it is because of a burst of free radicals when the blood supply is re-established. We call this reperfusion injury. This happens because of the high oxygen content of the returning blood flooding the penumbra region, which generates high levels of new free radicals. Numerous studies have shown that such things as magnesium, curcumin, quercetin, baicalein, hesperidin, resveratrol, naringenin, DHA, vitamin E, vitamin C, and anthocyanadins can prevent this damage and protect the brain during a stroke. Not only do these compounds suppress free radicals and lipid peroxidation, they are also powerful inhibitors of microglial activation and immunoexcitotoxicity.

Adaptogens That Will Improve Your Brain Function
Care2, August 2018
If you haven’t heard, turmeric contains a compound known as curcumin, which acts as a powerful anti-inflammatory in the body. What’s more, curcumin also has neuron stimulating, healing, and protective properties, which is why it is being researched as a potential healer for those who have suffered from Alzheimer’s or a stroke. Other research has shown that curcumin may possess powerful antidepressant properties, potentially making it a natural, side effect-free option for those suffering from mild and moderate depression. Pretty much, if you have an inflammatory condition, curcumin is on the case.

Curcumin supplementation regulates lipid metabolism in broiler chickens
Academic, August 2018
Curcumin plays an important role in reduction abdominal fat deposition by decreasing the hepatic and plasma lipid profile and affecting the expression levels of genes related to lipogenesis and lipolysis including ACC, FAS, SREBP-1c, ACLY, PPARα, and CPT-I.

X-ray Crystallography Reveals How Curcumin Inhibits Cancer
WorldHealth.net August 2018
X-ray crystallography and kinase-inhibitor specificity profiling has revealed that curcumin binds to the kinase enzyme dual specificity tyrosine regulated kinase at the atomic level, an interaction that impairs cell proliferation and reduces cancer burden, as published in the Proceedings of the National Academy of Sciences. Researchers from the University of California in collaboration with Peking University and Zhejiang University discovered the previously unreported co-crystal structure of curcumin to bind to protein kinase target biochemical interaction of the naturally occurring turmeric compound binding to and inhibiting DYRK2 leading to impediment of proteasome; who also note that curcurmin alone may not be the answer as it is expelled from the body quickly, to be an effective drug it needs to be modified to enter the bloodstream and stay long enough to target cancer. Kinases IKK and GSK3 enzymes were thought to be curcumin targets leading to anticancer effects, but the co-crystal structure of curcumin with DYRK2 along with an 140 panel kinase inhibitor profiling has revealed curcumin binds strongly to active sites of DYRK2 inhibiting it 500 times more potently than GSK3 or IKK, showing anticancer potential for chemo-sensitive and proteasome inhibitor resistant and adapted cancers.

Curcumin: More Powerful Than Drugs
NewsMax, August 2018
Curcumin, an organic compound extracted from the spice turmeric, is a flavonoid. It is the curcumin that gives the spice its bright yellow color. Turmeric, a relative of ginger, is in the family of plants called Zingiberaceae. The spice turmeric contains a number of beneficial compounds, but the most important are the curcuminoids: curcumin, demethyoxycurcumin, and bisdemethoxycurcumin. • Antimalarial • Antibacterial • Antiviral • Antioxidant • Antiseptic •Anticancer It is also neuroprotective, lowers cholesterol, and reduces hardening of the arteries. Studies have shown that this increases curcumin absorption by 11 times in plasma (the liquid component of blood in which cells are suspended) and fourfold in the brain. Mixing with oil also allows concentrations of curcumin to become high enough in the brain to provide protection against inflammation. Human studies have shown that even in very high doses (as much as 10,000 mg per day), curcumin has little toxicity. It is very safe and can even be given intravenously.

Curry powder slows cancer growth
New Telegraph, August 2018
Scientists from the University of California said a chemical in curry powder could fight cancer. The scientists have suggested that curcumin, the chemical in turmeric, could slow the growth of tumours in breast and blood cancers. Curcumin is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric, a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavouring, and food colouring. It does this by making cancer cells less able to break down or destroy other cells. Curcumin could be used to fight cancer because when in the blood stream, it binds to a specific type of enzyme called DYRK2 and, when the two are connected, cells cannot reproduce as quickly. Co-author, Jack Dixon, said curcumin may offer new opportunities for hard-to-treat triple-negative breast cancer and multiple myeloma treatment.

Evidence-based complementary treatment of pancreatic cancer: a review of adjunct therapies including curcumin
Cancer Management and Research, August 2018
Curcumin is the most studied of the nutraceuticals that are considered anticancer agents found in natural plants. Curcumin, from the plant Curcuma longa and a component of turmeric, has exhibited multiple anticancer effects in numerous studies in pancreatic cell lines and mice studies.95114 When used in combination, curcumin has also been shown to potentiate the effects of other cytotoxic agents, including gemcitabine, cisplatin, oxaliplatin, and 5-fluorouracil, in preclinical models of a variety of cancers.96,105 Most importantly, it seems to prevent chemoresistance especially to gemcitabine.102,104109  A low incidence of cancer has been documented in countries that incorporate high consumption of turmeric root, of which curcumin is believed to be the active ingredient.110,111 After testing >1,000 different potential agents for cancer prevention, the National Cancer Institute has chosen only 40, of which curcumin was included, to be moved to clinical trials.112 In several mice studies, curcumin has been shown to prevent cancer including mammary adenocarcinoma, esophageal cancer, and familial adenomatous polyposis.113115Curcumin has demonstrated a plethora of functions affecting various cell signaling pathways at multiple levels, as shown in Figure 3. Studies have identified numerous factors inhibited by curcumin related to cancer cell survival, proliferation, invasion, angiogenesis, and metastasis, suppression of apoptosis, and chemoresistance. Curcumin has been shown to inhibit a variety of factors including STAT3,100 COX-2,117 survivin,100 miR-200, and miR-21,111 the hedgehog pathway,118 and IAP proteins.119 Additionally, it has been demonstrated to activate the cell cycle inhibitors, p27 and p27,94 and upregulate the p53 modulator of apoptosis.112 Curcumin has been shown to inhibit pancreatic tumor growth and angiogenesis in mouse models.120 Curcumin’s most important effect seems to stem from inhibition of the transcription factor NF-κB and all its downstream products.96,97,110,117,118 Many lines of evidence suggest that NF-κB plays a major role in growth, proliferation, angiogenesis, and most importantly, chemoresistance.104106,117,121 Becoming resistant to chemotherapy is the main cause of death in most pancreatic patients. Curcumin seems to block this resistance.122 For example, one study showed that resistance to gemcitabine is induced by NF-κB activity and that curcumin inhibits this process.107 A recent study demonstrated curcumin restores sensitivity in gemcitabine-resistant cancer cells and confirmed this finding in a xenograft mouse model.108

Curcumin suppresses the progression of laryngeal squamous cell carcinoma
OncoTargets and Therapy, July 2018
Curcumin is a polyphenol extracted from the rhizomes of Curcuma longa with extensive biological and pharmacological effects. Curcumin administration upregulated miR-145 expression in LSCC cells in a dose-dependent manner. miR-145 overexpression and curcumin treatment both markedly suppressed cell proliferation, migration and invasion and induced cell cycle arrest and apoptosis in LSCC cells. Moreover, curcumin treatment reversed the enhanced effects on cell viability, migration and invasion and the inhibitory effects on apoptosis conferred by anti-miR-145 in LSCC cells. Curcumin treatment dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR pathway in LSCC cells. Conclusion: Curcumin suppressed LSCC progression through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.

Conditions Curcumin Helps Fight
Care2, July 2018
Obesity: If you’re having trouble losing weight you might want to consider adding more turmeric to your diet and supplementing with curcumin. That’s because research in the journal Biofactors found that the spice alleviated the inflammation isolated as a cause in overweight and obesity. It not only helped with obesity, it helped to protect against some of the health-damaging effects of obesity. Ideally choose a standardized extract of curcumin.
Memory Boosting: Research published in the Journal of Psychopharmacology showed that within only one hour after taking a supplement containing one of turmeric’s active ingredients, curcumin, study participants had a significant improvement in memory and attention tasks compared to the placebo group.
Alzheimer’s Protection: Research shows that the curcumin may even help to protect the brain against the plaque-formation found in Alzheimer’s disease. It seems to work by preventing the formation of beta amyloid plaques—which are key factors in Alzheimer’s disease. Even Alzheimer’s patients who exhibited severe symptoms, including: dementia, irritability, agitation, anxiety and apathy, had excellent therapeutic results when taking curcumin, according to another study published in the Japanese medical journal known as Ayu.
Colon Cancer Prevention and Treatment: Curcumin not only shows benefits for prostate cancer, it has been found in multiple studies to reduce colon cancer risk. In one study published in Cancer Prevention Research researchers found that curcumin suppressed the ability of colon cancer cells to proliferate, suggesting it may be beneficial in preventing and treating the disease.
Tendonitis: A root similar to gingerroot, turmeric contains a potent compound that, not only gives it its signature yellow color, but also its anti-inflammatory properties. In a study published in the Journal of Biological Chemistry researchers found that curcumin improved the healing of tendonitis, which involves inflammation of the tendons that help maintain our structural integrity.
Urinary Tract Infections: Recent research in the Journal of International Molecular Sciences found that curcumin helps to prevent kidney stones from forming in the urinary tract. It appears to prevent them from crystallizing in the first place.

Curcumin increases glutathione production
Inside Tucson, July 2018
The UA College of Nursing recently received a 1.6 million dollar grant to research the potential of curcumin at combatting the acute lung injury. This five-year grant from the National Institutes of Health allows researchers to study whether the non-pharmacological supplement curcumin can be used as medicine against the disease. Alcohol abuse depletes cells’ glutathione, an important antioxidant in the lung. Research shows when glutathione combines with oxygen, it can result in fatal respiratory failure. Curcumin, naturally found in turmeric, has proven effective as a non-pharmacological treatment for a variety of inflammatory diseases, and increases glutathione production.

Anti-Cancer Mechanism of Curcumin Outlined
MedicalResearch.com July 2018
Curcumin is good for cancer prevention since it blocks inflammation and tumor cell metabolism. These two activities are likely to prevent cancer or at least to delay its development. Consider that delaying cancer development means years of healthy life while cancer therapy means life with cancer, which is not the same. We are working with pure curcumin, no derivates, no additives with commercial interest.

University of Arizona Awarded Grant To Research Healing Powers Of Curcumin
KJZZ, July 2018
The University of Arizona College of Nursing was awarded a $1.6 million grant to research the healing potential of the substance curcumin for acute lung injury. Acute respiratory distress syndrome can be lethal and is expensive to treat. Researcher Dr. Charles Downs said he hopes the study will lead to the development of a cure. “It looks like it may hold some promise in this area primarily because of its antioxidants and beneficial effects,” said Downs. Curcumin is a compound found in the spice turmeric and has been used to reduce inflammation.

What exactly is curcumin and what is it good for?
Mind Body Green,  July 2018
Turmeric is a rhizome (underground root stem) of the leafy Curcuma longa plant. Also known as Indian saffron, turmeric has been a must-have ingredient in Indian cooking and medicine for thousands of years. Curcumin, the powerful medicinal compound that gives turmeric its health benefits, is best consumed in food, with fat and pepper.

Curcumin can shrink tumors
San Diego Tribune, July 2018
In one clinical study on pancreatic cancer, two patients out of 25 had good responses to large, daily doses of curcumin. Those two experienced tumor shrinkage for three years. “That doesn’t sound like a lot but most drugs won’t work very well for pancreatic cancer.” Curcumin turns off something called NF-kappa B that increases the production of several types of proteins that promote tumor growth. Second, it promotes apoptosis, which is the programmed death of cells in our bodies. Apopstosis is halted in cancer cells, allowing them to flourish. Curcumin reinvigorates that programmed cell death.

Can curcumin really help with arthritis, inflammation and headaches?
WKTR, July 2018
"Turmeric contains the chemical curcumin, found safe in six human trials," explained Dr. Light. "Curcumin, when studied, demonstrated anti-inflammatory activity inhibiting different parts of the inflammatory system. Turmeric can be used as an anti-inflammatory and may lessen the symptoms of arthritis and headache caused by inflammation."

UA receives $1.6m grant to examine the healing potential of curcumin for acute lung injury
Eureka Alert, July 2018
Curcumin, a compound found in turmeric, has proven effective as a nonpharmacological treatment for a variety of inflammatory diseases, and an increase of GSH synthesis. Looking to evaluate curcumin's effectiveness in facilitating the normal production of GSH, University of Arizona College of Nursing Assistant Professor Charles Downs, PhD, ACNP-BC, FAAN, has received a five-year $1.6M RO1 grant from the National Institutes of Health. Using a carefully designed murine model in his study, "Using Proteomics to Develop Personalized Health Strategies to Prevent Lung Injury in Model Systems," Dr. Downs hopes to demonstrate that curcumin reverses impaired protein function to restore lung fluid balance. Acute respiratory distress syndrome occurs in response to inflammatory stresses such as pneumonia and is characterized by profound inflammation and a build-up of excess fluid in the lungs that culminates in respiratory failure. Although researchers are aware of the physiological disorders associated with the syndrome, current therapies are supportive rather than curative, Dr. Downs said.

Value Your Memory? These Nutrients Will Keep It Strong
ZME Science, June 2018
Curcumin, the compound that makes turmeric bright yellow, has been in the news a lot lately because of its health benefits, and many of those benefits center on the brain. In particular, curcumin can reduce brain inflammation and increase the availability of the antioxidant glutathione. Brain inflammation is a leading cause of neurological damage and degeneration, so find a way to work it into your diet, whether in curry, golden milk, or as a stand-alone supplement. If you are going to take curcumin as a supplement, consider mixing it with coconut oil, olive oil, or even that brain health booster fish oil for improved absorption.

Muscle Atrophy Cures Found At The Supermarket
The Eagle, June 2018
Our lab has shown a causal role that reactive oxygen species (ROS) play in starting and maintaining this atrophy process. ROS are generated through metabolic and chemical reactions in the body and are normally referred to as free radicals in the general population. Disuse results in a spike of ROS and this causes movement of an enzyme nNOS (neuronal nitric oxide synthase) from the cell membrane to the interior of the cell. This movement of a molecule that normally resides at the cell membrane sets off a cascade of intracellular events that lead to the breakdown of the muscle cell. Our interventions of fish oil and curcumin aim at scavenging these excess ROS. By dealing with the high levels of ROS we can mitigate the cellular processes that lead to muscle breakdown and preserve muscle mass. It’s also important to note that these two interventions have been shown to diminish muscle atrophy when used alone and our lab wanted to see if combining both treatments would result in a more profound “rescue effect.” This intervention experiment is also important because many drugs created to combat muscle atrophy are quite expensive and often times have negative side effects. Fish oil and curcumin are not toxic and are easily available to any average person shopping at the local Wal-Mart.

Curcumin Health Benefits
SimpleMost.com June 2018
One of the star ingredients here is turmeric, and specifically the curcumin present in the golden spice. A 2013 study showed that curcumin has therapeutic properties for human diseases such as cancer and Alzheimer’s. Curcumin also offers a number of other health benefits, including increased antioxidant capacity of the body and the ability to neutralize free radicals. It’s also said to improve brain function, lower the risk of heart disease and help those suffering from arthritis by reducing inflammation.

Plants That Help Your Brain and Memory
Care2, June 2018
Curcumin, the active ingredient in turmeric, has been linked to a wide variety of health benefits. One study found that participants had significantly improved memory and attention within one hour after taking a curcumin supplement. Four weeks on the supplement enhanced their working memory, energy levels and calmness as well as lowered their stress levels.

Turmeric – What is That?
Kiowa County Press, June 2018
Curcumin is what gives turmeric its yellow-orange coloring. Curcumin is the active ingredient found in turmeric. It has been said that it may be a contributor to helping break down fat cells in your body; and, because of its natural anti-inflammatory agents, turmeric may help reduce joint and muscle pain. Other positive effects of curcumin include aiding in digestion, lower cholesterol, relief of arthritis and cystic fibrosis symptoms, prevention of some cancers, and lower blood pressure.

Reduce your risk of getting cancer
NZ Herald, May 2018
Healthista's nutrition director, Rick Hay, has shared what foods are best for a cancer awareness diet and 10 tips to help boost your health. "Top of my herb and spice list is turmeric," says Hay. "The active ingredient is curcumin which is a key anti-inflammatory agent." Curcumin can stop cancer cells and tumours from growing, especially in regards to breast, bowel and skin cancer cells. Black pepper is also beneficial in helping the body to absorb curcumin.

Anti-inflammatory Turmeric Protects Against Diabetes
ReliaWire.com May 2018
Curcumin is the main active ingredient in turmeric, which has proven anti-inflammatory and anti-oxidant properties. This naturally sourced and bioactive compound is easy to produce, has no side effects and can help to reduce inflammation in an array of inflammatory diseases; including obesity and diabetes. Scientists from Shandong University in Jinan, China found that curcumin improved glucose tolerance and insulin sensitivity in mice that were fed a high fat diet; and that blocking activation of the NLRP3 inflammasome was key to preventing high fat diet-induced insulin resistance.

Top 3 Signs of Ageing: Why This Spice Could Be You Best Anti-Ageing Companion
NDTV May 2018
Curcumin In Turmeric May Boost Memory and Uplift Mood too, claimed a recent study. The study, published in the American Journal of Geriatric Psychiatry, examined 40 adults between the ages of 50 and 90 years who had mild memory complaints.For the study, they were randomly assigned to receive either a placebo or 90 milligrammes of curcumin twice daily for 18 months. People taking curcumin improved by 28 per cent over the 18 months in their memory tests. There were mild improvements in mood for people taking curcumin. According to the researchers, taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years. One of the bets way to include Haldi in your diet is through Haldi doodh. According to Ayurveda expert Ashutosh Gautam, "It is because curcumin has the ability to get absorbed in the fat and tissues of our body and that is how it benefits the body. Milk becomes a smooth medium through which curcumin travels better and speedier to those fats and tissues facilitating its better absorption".

Why Turmeric Is the Golden Spice That'll Make Your Health Nice
PopSugar, May 2018
The active compound in turmeric, curcumin, is great at decreasing exercise-related muscle soreness due to its antioxidant properties. It also helps boost muscle recovery so you can get back to the gym right away. If your gut is easily irritated by certain foods, adding turmeric to your dish or having it as a shot before will help a lot with any bloat. Curcumin works by inhibiting enzymes that increase inflammation in the body.

Healthy Living: Turmeric, more than a spice
News Tribune, May 2018
Several studies on the effects of turmeric's active compound curcumin found reduced inflammation in people with osteoarthritis of the knee. Both pain and C-reactive protein levels were lowered. Testing showed collagen breakdown and overall disease activity was reduced. Additionally, research on rheumatoid arthritis found some patients found the anti-inflammatory properties as beneficial as cortisone. How? Turmeric inhibits the breakdown of arachidonic acid. Turmeric's combination of antioxidant and anti-inflammatory effects explains why many people with joint disease find relief when they use the spice regularly. Turmeric can offer help with several digestive issues. The University of Maryland Medical Center reported the curcumin in turmeric stimulates the gallbladder to produce more bile. This may help improve gas, bloating, nausea, appetite loss, belching and stomach discomfort. The curcumin may also be beneficial in inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. However, turmeric should not be used with stomach ulcers, as it may increase stomach acid in some people. Turmeric also has been shown to lower blood sugar and LDL cholesterol. It also keeps platelets from clumping together, meaning it might stop blood clots from forming on your artery walls. Because of this people currently using blood-thinning drugs should be aware the effect might be intensified with turmeric. Interactions of curcumin within the body improve insulin resistance, hyperglycemia, hyperlipidemia and other inflammatory symptoms associated with obesity and metabolic disorders. In addition, studies show curcumin seems to delay liver damage that can eventually lead to cirrhosis. Clinical studies have shown frequent use of turmeric to lower rates of breast, prostate, lung and colon cancer.

Herbs that can give your weight loss plan a boost
Times of India, May 2018
According to a 2009 study by Tufts University, turmeric can help your body burn fat. In the study, there were two groups of mice, one was fed curcumin while the other wasn’t. The results were that the group of mice that had curcumin lost more weight than the other group that did not have it. Turmeric is a warming spice, it increases the body heat which can boost your metabolism and provide other health benefits.

Healthy haldi
Times of India, May 2018
Curcumin’s anti-inflammatory properties make it an effective immunity booster, mitigating incidences of infection, disease. Curcumin helps block the conditions that lead to cardiovascular damage, which helps manage blood pressure and reduces the formation of clots. More and more studies are making linkages between haldi and its positive effect on anxiety. Curcumin seems to boost serotonin – the happy hormone, while lowering cortisol – the stress hormone. It is the curcumin in turmeric that gives it its antioxidant properties. Oxidative damage (the chemical reactions that oxygen performs inside our bodies) leads to the development and proliferation of free radicals, which are highly reactive molecules. Free radicals have the potential to damage organs and also create a crazy, disease-prone, inflamed environment inside our body. Antioxidants help flush out free radicals and also work as a brilliant anti-inflammatory.

5 Foods for Joint Pain Relief
NewsMax, May 2018
The active ingredient in turmeric is curcumin, which has been shown to suppress the action of a number of chemical signals in the body, such as tumor necrosis factor, that attack joints. Curcumin also blocks other inflammatory signals, including those in the pro-inflammatory COX-2 pathway. A study presented in the journal, Experimental Neurology (2016), revealed that curcumin counteracted the outcome of traumatic brain injury by decreasing oxidative stress, and increasing synaptic simplicity and cognition. Turmeric also stimulates a key antioxidant pathway called Nrf2.

A healthy heart diet
MVariety.com May 2018
“A study of about 121 patients undergoing coronary artery bypass disease showed a positive response to turmeric. There was a 65 percent decreased heart attack rate for patients who were given a dose every day.” Forsyth said curcumin, a substance in turmeric, has a positive effect on your endothelium, which is the lining of your blood vessels. Endothelium is responsible for regulating blood clots, blood pressure, and all other factors that lead to many heart diseases. Researchers at the University of Toronto found that curcumin blocks a wide range of biochemical reactions involved in cardiac hypertrophy (enlargement of the heart chambers), inflammation, and fibrosis.

Feed your brain well
Times of India, May 2018
 Curcumin: It is the active ingredient in turmeric. Curcumin has been shown to boost BDNF (Brain-Derived Neurotrophic Factor), which helps lower the risk of brain diseases. Curcumin works best when heated with food. It is known to add to brain clarity and reduce mind fogginess.

To stay healthy, include natural spices in your diet
Daily Nation, May 2018
der. Curcumin is a chemical compound found in turmeric, this compound is responsible for the anti-inflammatory, anti-cancer and antioxidant properties of turmeric. In isolation, absorption of curcumin in blood stream is low, however, the absorption can be enhanced by piperine found in black pepper. As an anti-inflammatory agent, curcumin attacks the inflammatory pathway, on this pathway, it blocks the NF-kB molecule from accessing the cell nuclei. It is in the nuclei where the NF-Kb molecule triggers the gene associated inflammation, which causes chronic diseases. Curcumin has a chemical structure that has the ability to inhibit the three major enzymes (lipoxygenase, cyclooxygenase-2 and inducible nitric oxide synthase) that promote inflammatory process. Other disorders whose risks can be reduced by curcumin include heart and brain diseases, osteoarthritis, depression, eye swelling, skin cancer and age-related ailments.

Here's how Turmeric can help you lose weight
E Times, May 2018
The primary antioxidant present in turmeric is curcumin. Turmeric is said to help one deal with stomach issues, metabolic disorders, obesity and many more problems. Though having huge quantities of turmeric is surely not a way to lose weight, but turmeric is said to reduce the inflammation associated with obesity. Thus, it can give your weight loss plan a boost.  Obesity leads to inflammation, which increases your risk of developing chronic diseases, including diabetes and heart disease. Curcumin, which is an antioxidant, suppresses the inflammatory messaging in fat, pancreatic and muscle cells. This can help reduce high blood pressure, high cholesterol, high blood sugar and other metabolic conditions, says a study published in European Journal of Nutrition.

Turmeric use linked to weight loss
Citizen Digital, May 2018
Curcumin, an active ingredient in Turmeric, has a strong anti-oxidant property. This article highlights the various benefits of using the spice: prevents heart diseases improves immunity aids in weight loss and metabolism prevents neurological diseases promotes brain health prevents cancer offers excellent anti-oxidant properties delays aging can be used as a natural painkiller treats skin pigmentation prevents hair loss helps treat dandruff cures stretch marks soothes burns heals cracked feet aids in exfoliation aids in diabetes treatment works as a natural antiseptic detoxifies the liver reduces menstrual pain treats digestive disorders.

Want to fight your everyday blues? These kitchen ingredients may be the perfect solution for you
TimesNowNews, April 2018
Turmeric is a widely used spice in Indian households. Apart from its anti-inflammatory nature, the spice also brings a distinct flavour and aroma to your meal which has mood-lifting properties. There is a compound called curcumin that has been linked to improving mood, according to a study conducted by UCLA. “Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimer’s disease and major depression,” said Dr Gary Small, director of geriatric psychiatry at UCLA’s Longevity Center and of the geriatric psychiatry division.

Curcumin and a good book
News Miner, April  2018
Cumin and curcumin, which is found in turmeric, are both important ingredients in cuisines from North Africa to India, and both possess powerful medicinal qualities. Research at UCLA has shown curcumin has “improved memory and mood in people with mild, age-related memory loss.” Already known for its anti-inflammatory and antioxidant properties, eating lots of curcumin-rich turmeric “has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance.”

Is turmeric really a 'wonder drug' for migraines?
Daily Mail, April 2018
Good brands for curcumin will give you the milligram dosage of curcumin specifically listed on the bottle which is why she recommends people buy curcumin supplements as opposed to turmeric. Although more research is needed to prove curcumin's effectiveness, Dr Green said that in addition to other prescriptions, she prescribes it to her patients to treat migraines. She said it does make her patients feel better. She said she uses it as a preventive measure for patients who experience 14 migraines or less per month. 'Prevention then becomes imperative for many of these patients, and while there are a slew of prescription medications we can use for prevention, increasingly people are looking for alternatives,' Dr Green said. Rissetto said other health benefits associated with curcumin includes, a boost in brain function and a lower risk of developing brain diseases like Alzheimer's disease. A 2008 study published in the Annals of Indian Academy of Neurology found that curcumin decreased Beta-amyloid plaques, which is a hallmark of Alzheimer's. She said it has also been linked to improved heart function.

Spice is able to prevent dementia
Siv Times, April 2018
Curcumin is a component of well-known condiments, recently conducted a lot of research about its positive and negative effects on health, reports the Chronicle.info with reference to ladyhealth.com.ua. Scientists from Israel have also contributed, showing that curcumin helps to maintain brain health and reduces the risk of development of Alzheimer’s and Parkinson’s. Scientists from an Israeli hospital Hadassah has tested the potential of dietary supplements to strengthen the intestinal cells to prevent uncontrolled leakage of intestinal contents into the bloodstream. In combination with phospholipids, curcumin showed anti-inflammatory properties, ability to reduce the intervals between the cells and make the intestines less permeable. The disadvantage of curcumin is rapid decomposition and removal within two hours. However, its positive effect lasts for 72 hours even after complete removal.

Key curry ingredient could have amazing health benefits – and improve memory
Mirror, April 2018
Curcumin has been analysed in a study published in the American Journal of Geriatric Psychiatry. Scientists at the University of California in Los Angeles examined the effects of the ingredient on people with mild and age-related memory loss. "Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimer's disease and major depression," said Dr. Gary Small, study author and the director of geriatric psychiatry at UCLA's Longevity Center. In total, 40 participants aged between 50 and 90-years-old, each with mild memory loss and/or complaints, were brought in. Half were assigned 90 milligrams of curcumin twice daily for 18 months; the rest were given a placebo. Researchers found that those who took curcumin saw improvement in both memory and mood. The substance levels in their blood was monitored, while cognitive assessments and PET scans were undertaken too. The study says that memory tests show people taking curcumin improved by as much as 28 per cent over the timeframe. Their overall disposition also improved, according to scientists. The university plans to continue its research and conduct a second study with a greater number of participants. Also to be explored is whether curcumin works better in certain ages, its impact on those with a genetic risk of dementia, and if it can be used to treat people with depression. Dr Small said: "These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years."

Fighting for those who fought
The Batt, April 2018
The study, funded by the Department of Veteran Affairs (VA) and the Department of Defense, focused on a curcumin, a component of turmeric. Turmeric is a spice found in curry and has many health benefits that could help with the disease long term. The spice has been used in animal models and has shown signs of reversing GWI. “We were very pleased in our tests that curcumin showed better signs of reactions among animals than the true control group,” Shetty said. “That can lead us to believe there is good ahead in or long road of discoveries and studies.”

Can Turmeric Bring the Fight to Mesothelioma?
Asbestos.com April 2018
There are two aspects to the 2017 turmeric and mesothelioma experiment. In both parts, the researchers focused on curcumin, a substance found in abundance in turmeric. First, they studied how curcumin curbs cell growth in mesothelioma cancer. The researchers found the spice component thwarted mesothelioma. Next, researchers examined how curcumin protected mice against mesothelioma tumor development. Compared with the mice who received plain corn oil, the mice who received the intraperitoneal curcumin and corn oil mixture: Experienced reduced risk of developing tumors overall, Developed fewer tumors, Had much smaller tumors, Lived significantly longer.

Add turmeric to your diet to improve your well-being
The Gauntlet, April 2018
Kris Gunnars of the health-care blog Authority Nutrition says that turmeric is rich in a powerful anti-inflammatory called curcumin. Gunnars says that curcumin is equally as effective at fighting inflammation as pharmaceuticals — but without the nasty headaches and stomach pain that they typically cause.

Why Turmeric Is Good For High Blood Pressure
NDTV, April 2018
Turmeric is popular for its antioxidant curcumin which helps in lowering blood pressure. Its antioxidant properties are the responsible for regulating blood pressure in the body. Curcumin also protects against vascular dysfunction in the body. Having high blood pressure in this case, causes further damage to tissues in arteries. LDL (or bad) cholesterol begins to deposit in arteries in the form of plaque in the walls of arteries. Curcumin in turmeric can help in preventing further damage caused to arteries because of high blood pressure. The anti-inflammatory property of turmeric is another reason which contributes to the popularity of the spice. Curcumin has anti-inflammatory properties which help in keeping hypertension at bay. Inflammation in the body is risky because it can contribute to stiffness in heart's arteries - which in turn may raise blood pressure. Consuming turmeric regularly can help in keeping blood pressure under control.

Focus on Fitness: Boosting memory and avoiding obesity
Plant City Observer, April 2018
Scientists at UCLA worked with 40 volunteers, age 50 through 90, who all had memory loss complaints. Their study, published in January in the American Journal of Geriatric Psychiatry, found using curcumin twice a day for 18 months improved memory and mood tests, as well as brain scans. Curcumin is the active ingredient in the Indian spice turmeric. Besides cooking applications, turmeric has been used by ancient cultures for brain health for many centuries. Turmeric gives Indian curry its color and flavor. Manufacturers often use turmeric to color cheese, butter and prepared mustard. Known as a powerful antioxidant, curcumin scavenges free radicals in the human body to stop cell membrane damage. Curcumin lowers inflammation by reducing the enzymes that cause it. Chinese and Ayurvedic medicine systems also use turmeric to treat digestive and liver conditions as well as wounds and skin diseases. If you decide to take curcumin vitamin capsules, select a quality product from a reputable manufacturer.

Arthritis symptoms, spice could prevent joint pain
Express, April 2018
One compound within the spice - curcumin - has pain-relieving characteristics that may help to relieve arthritis suffering. Curcumin is also one of the most effective anti-inflammatory compounds in the world, researchers said. The compound may even be beneficial for Alzheimer’s disease patients. Turmeric is a yellow powder that works an an anti-inflammatory, scientists have claimed. One compound within the spice - curcumin - has pain-relieving characteristics that may help to relieve arthritis suffering. Curcumin is also one of the most effective anti-inflammatory compounds in the world, researchers said. “While arthritis cannot be cured, it seems that a high dose of curcumin can be just as [or more] effective than at least the most common medication prescribed for the condition. “Turmeric comes from India and other Southeast Asian countries. The dried root of the Curcuma longa plant is ground into the distinctive yellow turmeric powder. “The best part about turmeric? Not only is it well-researched, incredibly potent and historically significant, it’s also safe.”

Curcumin Suppresses IL-1β Secretion and Prevents Inflammation
Journal of Immunology, April 2018
Turmeric is traditionally used as a spice and coloring in foods. Curcumin is the primary active ingredient in the turmeric, and compelling evidence has shown that it has the ability to inhibit inflammation. We report that curcumin inhibited caspase-1 activation and IL-1β secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow–derived macrophages. The inhibitory effect of curcumin on inflammasome activation was specific to the NLRP3, not to the NLRC4 or the AIM2 inflammasomes. Curcumin inhibited the NLRP3 inflammasome by preventing K+ efflux and disturbing the downstream events, including the efficient spatial arrangement of mitochondria, ASC oligomerization, and speckle formation. Reactive oxygen species, autophagy, sirtuin-2, or acetylated α-tubulin was ruled out as the mechanism by which curcumin inhibits the inflammasome. Importantly, in vivo data show that curcumin attenuated IL-1β secretion and prevented high-fat diet–induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3-deficient mice. Curcumin also repressed monosodium urate crystal–induced peritoneal inflammation in vivo. Taken together, we identified curcumin as a common NLRP3 inflammasome activation inhibitor. Our findings reveal a mechanism through which curcumin represses inflammation and suggest the potential clinical use of curcumin in NLRP3-driven diseases.

Turmeric linked to avert the risk of cardiovascular diseases, the recent study claims
AskTelegraph.com March 2018
Benefits of curcumin: Curcumin has anti-inflammatory, anti-allergic, anti-microbial, and antioxidant properties that help in blood clotting. It can act as a substitute for aspirin. Helps in treating of bone or joint disorders such as arthritis, osteoarthritis and rheumatoid arthritis at the faster rate. It also helps in fighting against skin infections and skin disorders. “Clinical trials reveal that consuming 4 grams of turmeric continuously for 4 days before surgery and 5 days’ post-surgery can reduce the risk of myocardial infarction and chances of by-pass surgery by 56 percent as compared to placebo”, discloses Natural Medicines Database. Since curcumin compound found in turmeric has antioxidant properties, it can help in the oxidation of vital body parts thus dropping the chances of deadly cancer. Additionally, consuming 1.4 grams of turmeric on daily basis can help to thwart low-density lipoprotein (LDL), total cholesterol, triglyceride and very low-density lipoprotein (VLDL) cholesterol in individuals.

How this spice can give you an added health boost
Belfast Telegraph, March 2018
Researchers have found that curcumin, the bright yellow chemical produced by turmeric, is capable of interacting with a variety of molecules involved in inflammation, easing swelling, aches and pains in the joints and muscles. In fact, a study published in the National Center for Biotechnology Information found that cucurmin may be just as effective as aspirin and ibuprofen at suppressing the body’s inflammatory response. As well as bolstering the body’s natural antioxidant function by increasing glutathione levels, studies found curcumin’s molecular structure can neutralise harmful free radicals in the body, lessening the chances of disease. Multiple studies have found that the yellow pigment in turmeric root can help to maintain the function of the interior lining of your blood vessels. One study published in the Nutrition Research journal in 2012 even found that curcumin may be as effective in improving vascular function in post-menopausal women as a moderate exercise routine.

Turmeric component may ease Gulf War illness for vets
Futurity March 2018
We found the individuals with GWI treated with curcumin for 30 days showed better cognitive function and mood than the control group did.” The improvements were more than just functional. “Curcumin treatment helped in alleviating the brain inflammation seen in GWI,” says first author Maheedhar Kodali, a postdoctoral fellow. “It also enhanced the expression of genes that encode for antioxidants and normalized the expression of genes related to the function of mitochondria in the hippocampus.” “Particularly, the ability of curcumin to reduce the occurrence of activated microglia, a sign of eased brain inflammation, is remarkable,” Shetty says. The compound also seemed to enhance the formation of new neurons in the hippocampus, the part of the brain responsible for learning, memory, and mood and the region where new neurons are added throughout life in normal individuals.

Could a spice be the key to helping Gulf War Illness vets?
KCEN TV, March 2018
"Curcumin has been known to have antioxidant, anti-inflammatory and neurogenic properties, so that's why we thought it's a good candidate for testing," Shetty said. Doctor Shetty said, based on their recent studies, the bright yellow chemical in the spice is shown to improve cognitive function, reduce brain inflammation and act as an antioxidant. He went on to say it helped create new neurons in the brain. There is not one specific treatment for Gulf War Illness at this time. "We tested the efficacy of circumin immediately after the exposure to Gulf War illness-related chemicals. And we found the animals can maintain better cognitive function and reduce depressor-like behavior," Shetty said. The scientist went as far to say curcumin may even have the potential to prevent Alzheimer's disease, according to recent studies.

Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus
Science Direct, March 2018
This study showed that curcumin can mediate anti-inflammatory, antioxidant, neurogenic, and cognitive and mood enhancing effects in a condition such as GWI,” Shetty says. The findings correspond well with those of a separate study in humans from the University of California, Los Angeles, which recently showed curcumin improved the cognitive function of older adults by 28 percent. Curcumin maintains better cognitive and mood function in a model of Gulf War Illness. Curcumin alleviates neuroinflammation in a model of Gulf War Illness. Curcumin enhances hippocampal neurogenesis in a model of Gulf War Illness. Curcumin normalizes mitochondrial function in a model of Gulf War Illness. Curcumin enhances the expression of genes that encode antioxidant activity.

Eating Healthy And Natural May Keep Cancer At Bay
NDTV, March 2018
Curcumin, an active compound found in turmeric may help keep cancer at bay to a certain extent. Curcumin helps inhibit the growth of various cancer cells in most parts of the body. It is known to have anti-cancerous properties.

Natural supplements to stop lower back pain
Express, March 2018
Turmeric is the spice that gives curry its yellow colour. It contains the anti-inflammatory compound curcumin, that could help to relieve a painful back. Try taking up to 1,000mg of turmeric supplements everyday to reduce pain. “Turmeric contains curcumin, which is the active ingredient that has powerful anti-inflammatory abilities, anti-aging effects and reduces pain.”

Eating Curry May Improve Memory and Happiness, New Study Says
Newsweek, March 2018
The study was also double-blind, which means neither the doctor nor patient knew whether they were taking a placebo or the curcumin supplement. The participants received cognitive tests at the beginning of the study every six months and blood tests that monitored their curcumin levels. Memory improved by 28 percent over the course of 18 months among participants taking curcumin. There were mild improvements in mood, too, and brain scans revealed fewer signs of amyloid and tau, which are two abnormal proteins that form clumps in the brains of patients with Alzheimer's disease.

The secret behind Julianne Hough's white teeth is common household spice turmeric
Business Insider, March 2018
Turmeric has a key component called curcumin, which is a natural anti-inflammatory that clears bacteria. Turmeric itself has been around for a very long time. It’s the spice that gives curry its color and Indians have been using it as a cooking aid and medicinal herb for thousands of years. What makes it so beneficial to our bodies is its key component: curcumin, which is a natural anti-inflammatory that repairs damage and clears away bacteria.

Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function
 BMC Cardiovascular Disorders, March 2018
Administration of curcumin significantly delayed the onset of stroke and increased the survival of SHRsp, which was ascribed to decreased ROS and improved endothelial dependent relaxation of carotid arteries. In the presence of UCP2 inhibitor genipin, both curcumin-mediated decrease of ROS and increase of NO production were blocked. Our study suggests that curcumin exerts a stroke preventive effect by attenuating oxidative stress to improve vascular endothelial function, which might be associated with UCP2 signaling.

Curcumin shows promise for treating Gulf War illness
Tamhsc.edu, March 2018
Turmeric, a spice commonly found in curry, has long been touted for its health benefits. Now, evidence in animal models suggests that one of its components, called curcumin, may be able to reverse some of the effects of Gulf War illness (GWI), according to recent research published in the journal Brain, Behavior, and Immunity. This research was funded by the Department of Veterans Affairs and the Department of Defense.

Reasons why turmeric is scientifically good for you
TV3, March 2018
Researchers have found that curcumin, the bright yellow chemical produced by turmeric, is capable of interacting with a variety of molecules involved in inflammation, easing swelling, aches and pains in the joints and muscles. In fact, a study published in the National Center for Biotechnology Information found that cucurmin may be just as effective as aspirin and ibuprofen at suppressing the body’s inflammatory response. As well as bolstering the body’s natural antioxidant function by increasing glutathione levels, studies have found curcumin’s molecular structure can even neutralise harmful free radicals in the body, lessening the chances of disease. One study published in the Nutrition Research journal in 2012 even found that curcumin may be as effective in improving vascular function in post-menopausal women as a moderate exercise routine. Research has shown that curcumin has a similar effect as antidepressants on patients suffering from depression, mood swings and anxiety, and studies on mice found that daily doses of turmeric can even increase the amount of happy hormones (serotonin and dopamine) in the brain.

Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-κB pathway in pancreatic cancer cells
International Journal of Oncology, March 2018
Curcumin is a natural polyphenol compound derived from turmeric. It possesses multiple pharmacological properties, including antioxidant, anti-inflammatory and anti-tumor progression properties. To summarize, these results demonstrated that curcumin was able to prevent SOD-driven H2O2-induced pancreatic cancer metastasis by blocking the PI3K/Akt/NF-κB signaling pathway. The use of curcumin to inhibit the H2O2/Akt/NF-κB axis may be a promising therapeutic approach to the treatment of patients with pancreatic cancer.

Natural Ways to Help Prevent Alzheimer’s Disease
Care2, March 2018
Research shows that the compound curcumin, found in the curry spice turmeric, not only protects the brain against memory loss, it may even help to protect it against Alzheimer’s disease. Curcumin is the plant nutrient that gives turmeric its golden-yellow hue. It turns out this vibrant compound also holds tremendous promise against serious brain disease by preventing the formation of beta amyloid plaques, which are involved in Alzheimer’s. Alzheimer’s patients with severe symptoms, including dementia, irritability, agitation, anxiety and apathy, have shown excellent therapeutic results when taking curcumin, according to a study published in the Japanese medical journal Ayu.

Curry ingredient more effective than paracetamol at easing painful injuries
Guardian, March 2018
Turmeric is more effective than popular painkillers at easing the agony of sports injuries, new research suggests. After less than three weeks, taking a key component of the Indian staple spice, known as curcumin, eases injured rugby players’ discomfort just as much paracetamol or ibuprofen, but without their side effects, a study found. Those opting for medication over the curry ingredient are four times more likely to suffer gastro-related complications, the research adds. This study suggests the naturally-derived, curcumin-based product could represent a promising safe, analgesic remedy in painful osteo-muscular conditions associated with intense, high impact, physical activities.

Turmeric is more effective than paracetamol or ibuprofen at healing injuries
Deccan Chronicle, March 2018
A new study now suggests that turmeric is more effective than popular painkillers at easing the agony of sports injuries. The study found that after less than three weeks, taking a key component of the Indian staple spice, known as curcumin, eases injured rugby players' discomfort just as much paracetamol or ibuprofen, but without their side effects.. The researchers further believe that curcumin may also benefit sufferers of inflammatory conditions, such as arthritis patients, without causing the complications associated with many existing treatments. Results further reveal those taking curcumin are more likely to stick to their treatment regimen. The researchers analysed 50 rugby players from the Italian premier Piacenza club south of Milan who were suffering bone or muscle problems as a result of incidents, such as repeated tackling. Half of the study's participants were given the one gram curcumin-extract tablet Algocur, which is known as Turmeric+ in the UK, twice a day for up to 10 days. The remainder took painkillers. The findings were published in the European Review for Medical and Pharmacological Sciences journal. This comes after research released last month suggested turmeric may boost people's memories by nearly 30 per cent, as well as easing depression. Taking curcumin causes people to have significantly less protein build-up in the regions of the brain associated with memory and emotion, a study found. Past studies have also linked the onset of Alzheimer's disease to the accumulation of protein plaques in the brain. Curcumin, which gives turmeric its yellow color, is thought to improve memory and boost mental health due to its anti-inflammatory properties. Inflammation has previously been linked to both dementia and severe depression.

Curry ingredient turmeric is MORE effective than paracetamol or ibuprofen at easing painful injuries, study finds
Daily Mail, March 2018
Indian spice staple eases discomfort just as much as paracetamol or ibuprofen. Yet its key component curcumin does not cause their gastro side effects. Curcumin is a safe alternative to drugs after intense, high-impact exercise. Inflammatory-condition sufferers, like arthritis patients, may also benefit. Curcumin has been used as a herbal remedy in arthritis and heart disease.

Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells
Oncology Letters, March 2018
Curcumin is a phytochemical with potent anti-neoplastic properties. The antitumoral effects of curcumin in cells derived from chronic or acute myeloid leukemia have been already described. In conclusion, curcumin elicits different cellular mechanisms in chronic or acute myeloid leukemia cells and the powerful antitumoral effect was more potent in K562 compared with HL-60 cells.

Herbal cures for uterine fibroids
Guardian, March 2018
The results showed the mean diameter of leiomyoma were statistically different at before and after three and six month’s curcumin intake. And both mean volume of leiomyoma was statistically different at before and after three and six month’s curcumin intake. Adverse effect of curcumin was not found. Also, Egyptian researchers have successfully used turmeric, in clinical studies, to decrease the volume of uterine fibroids in women. The study published in Journal of American Science is titled “Curcumin a New Modality for Treatment of Uterine Myoma.” The results of the study found statistically significant decrease in the uterine volume and myoma volume (cm3), “again we find statistically significant increases in Hb percentage after treatment the bleeding stop completely in 88 per cent after two weeks treatment and after four weeks in 12 per cent of the cases.” The researchers concluded: “Curcumin is a new drug with multiple pharmacological actions, no reported side effects of significances for treatment of myoma.” Also, another study published in Gynecological Endocrinology showed curcumin suppressing fibroid cell replication by interacting with Peroxisome Proliferator-Activated Receptor-Gamma (PPARg). PPARg is a cell receptor that plays a role in controlling the cell cycle and cell division. It also has been found to suppress inflammation.

Nutritionist Says Everyone Over 30 Should Be on These Supplements
New Beauty, March 2018
I love CoQ10 and a curcumin—they're both antioxidants, so they work great if you’re looking to anti-age,” LeVeque says. “CoQ10 is known to help mitochondrial health and boost cellular energy, and as we age, you want to keep your mitochondria working efficiently because they're the energy powerhouse inside every cell in your body.” Additionally, coQ10 can protect skin against environmental stressors and free radicals, deterring any damage that can accelerate the aging process. “Curcumin—another good option—is the active ingredient inside turmeric and super anti-inflammatory,” adds LeVeque. Furthermore, curcumin has been proven to have a few under-the-radar health perks; most notably that it might be able to reduce the risk of Alzheimer’s.

Know the various health benefits of everyday spices and herbs
Review Online, March 2018
Turmeric. This yellow spice gets a lot of hype, and for good reason. It’s a good source of curcumin, an antioxidant that eases inflammation. Research suggests curcumin may help ease pain and lower the chances of heart attacks. Other research shows eating even small amounts of turmeric regularly may help prevent or slow down Alzheimer’s disease, possibly by helping prevent the brain plaques that lead to dementia.

Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells
Medicine, March 2018
Curcumin has been used as an alternative medicine for the treatment of infantile hemangiomas (IHs). We found that curcumin potently inhibited proliferation in HemECs, achieving low-micromolar IC50 (the half maximal inhibitory concentration) value. We also observed that treatment with curcumin induced apoptosis in HemECs, as evidenced by positively Annexin-V-FITC staining, caspase-3 activation, and cleavage of poly(adenosine diphosphate-ribose) polymerase (PARP) in the treated cells. Moreover, we showed that curcumin suppressed the expression of antiapoptotic protein myeloid cell leukemia-1 (MCL-1), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF).Altogether, our study suggests that the effectiveness of curcumin in IHs may be associated with its potent antiproliferative and apoptotic activities in HemECs.

Turmeric Can Help Prevent Heart Attacks, Doctor Says
Tech Times, March 2018
"The main active ingredient in turmeric is curcumin and it's used as an antioxidant, anti-inflammatory and has some action as an antiplatelet agent that can slow blood clotting, in a similar but more gentle way than aspirin," said Cotterel. Aspirin has also been used to help prevent heart attacks. Dr. Cotterel expressed turmeric can be used similarly, although there are no clinical trials to back up this up other than in people who have just gotten coronary artery bypass grafts. "Clinical research suggests that taking the turmeric constituent, curcuminoids, 4 grams daily beginning 3 days prior to surgery and continuing for 5 days post-surgery can decrease the relative risk of myocardial infarction following coronary artery bypass grafting by approximately 56 percent compared to placebo," according to the Natural Medicines Database. Turmeric's anti-inflammatory effects can help reduce joint pain, osteoarthritis, and may help pain related to rheumatoid arthritis. "Curcumin is another great way to get a higher dose of it so if used therapeutically, it's best to do for arthritis. You wouldn't overdose on it," said Dr. Cotterel. "Since it is an antioxidant, the spice can be sometimes used to help prevent some of the diseases associated with oxidation in the body such as cancer. It has also been found to be effective in itching from various sources," said Dr. Cotterel. In addition, other research suggests taking turmeric extract at 1.4 grams/day orally in two different doses over 3 months have the ability to reduce levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and triglyceride in patients aged 15-45 years-old.

Curcumin may serve an anticancer role in human osteosarcoma cell line U-2 OS by targeting ITPR1
Oncology Letters, March 2018
Treatment with curcumin was able to significantly increase the levels of CLTC and ITPR1 mRNA in curcumin‑treated cells compared with control. In addition, targeting ITPR1 with curcumin significantly promoted apoptosis and suppressed proliferation, migration and invasion. Targeting ITPR1 via curcumin may serve an anticancer role by mediating apoptosis, proliferation, migration and invasion in U-2 OS cells.

Turmeric Could Help Treat Endometriosis, Says Study
Womens Health, March 2018
A review of relevant studies published in the journal Biomedicine & Pharmacotherapy, examined the effect that curcumin, a compound found in turmeric, has on the disease. Results of in vitro and animal studies showed that curcumin reduced pain and inflammation through the suppression of inflammatory cytokines expression. It was also found to repress the invasion, attachment, and angiogenesis of endometrial lesions, inhibiting the disease's progression.

Curcumin and endometriosis: Review on potential roles and molecular mechanisms
Science Direct, March 2018
Turmeric, an important spice all around the world, is obtained from the rhizomes of Curcuma longa, a member of the Zingiberaceae family. It has been used in the prevention and treatment of many diseases since ancient times. Curcumin is the principal polyphenol isolated from turmeric. Several evidences have shown the anti-inflammatory, antioxidant, anti-tumor, anti-angiogenesis, and anti-metastatic activities of curcumin. In this review, relevant articles on the effect of curcumin on endometriosis and possible molecular mechanisms are discussed. The results of related in vitro and animal studies have shown that treatment with curcumin reduces inflammation through suppression of inflammatory cytokines expression. It also can inhibit invasion, attachment, and angiogenesis of endometrial lesions. Moreover, curcumin inhibits cell proliferation and causes cell cycle arrest and apoptosis. Thus, it may has potential benefits as a dietary and pharmacological agent for the prevention and treatment of endometriosis.

Turmeric is great, but look for curcumin
Herald Dispatch, March 2018
Finding a high-potency curcumin supplement can unfortunately be tougher than it sounds. Curcumin only occurs at a pretty low percentage in standard turmeric powder, somewhere roughly between 2 to 4 percent by weight. Many products on the market will claim to be "turmeric with curcumin." That sounds great, but doesn't really mean much, being that all turmeric contains curcumin. Instead of a somewhat vague label claim, pay attention to the supplement facts panel to see what percentage of curcumin is guaranteed per serving. The most-studied curcumin products on the market can range anywhere from 30 to 95 percent curcumin. It is also a pretty common trick to see a product claiming "made with 95 percent curcumin" on the front of the bottle, but after a glance at the supplement facts, it may only use a small amount of that curcumin extract in a base of regular turmeric powder. The high-potency extraction process takes a lot of raw material, therefore quality supplements can be a little on the expensive side. In certain curcumin supplements, one capsule can equal the absorption of up to 500 regular turmeric powder capsules, so it can be worth the extra price for the extra potency.

Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression
Oncology Letters, March 2018
Curcumin is a polyphenol compound that has been demonstrated to exert effective antiangiogenic, anti‑inflammatory, antioxidant, and antitumor effects. Curcumin treatment inhibited H22 cell proliferation and promoted H22 cell apoptosis in a dose‑dependent manner in vitro. In addition, curcumin treatment inhibited tumor growth in vivo at the concentrations of 50 and 100 mg/kg. Furthermore, curcumin treatment significantly decreased VEGF expression and PI3K/AKT signaling. The present findings demonstrated that curcumin inhibited HCC proliferation in vitro and in vivo by reducing VEGF expression.

Turmeric helps eliminate depression, alleviate pain, slow the aging process, protect the digestive tract, and prevent cancer
Pulse, March 2018
As a matter of fact, a number of laboratory studies on cancer cells have shown that curcumin, which is the principal curcuminoid of turmeric, does have anticancer effects. It has been observed to have the ability to kill cancer cells as well preventing more from growing. In addition, turmeric also has the best effects on breast cancer, bowel cancer, and stomach cancer and skin cancer cells. And curcumin, which is the principal curcuminoid of turmeric, happens to be a potent antioxidant that neutralizes free radicals due to its chemical structure as well as boosting the activity of the body's own antioxidant enzymes.

Study backs daily consumption of curcumin for your memory, mood
Jakarta Post, March 2018
The research study involved 40 adults aged between 50 and 90 years old who experience "mild memory complaints." They were randomly given "either a placebo or 90 mg of curcumin" twice a day. After 18 months, those who consumed curcumin were reported to experience "significant improvements in their memory and attention abilities," while those who were given the placebo did not. In addition to a 28 percent increase in their memory, the curcumin group were also found to enjoy "mild improvements in mood." “These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years,” said Small.

Turmeric and Curcumin
Pop Sugar, March 2018
Curcumin is the most active ingredient in turmeric. It's the chemical compound that naturally occurs in turmeric. Curcumin makes up 2 percent to 6 percent of the turmeric spice found in your cabinet, according to Andrew Weil, MD. In fact, curcumin gives turmeric its distinct yellow color. That color is passed on to curry, since turmeric is a main ingredient in that spice. But curcumin isn't just part of spices; it has powerful health benefits all its own, such as being an antioxidant and having antitumor properties. In addition, at least one study has found that curcumin can be effective as a treatment for depression. Even more recently, a 2018 study from UCLA found that curcumin can help improve mood and memory loss. ADVERTISEMENT This is a modal window. The media could not be loaded, either because the server or network failed or because the format is not supported. Just like turmeric, curcumin also has anti-inflammatory properties, making it a viable way to ease arthritis pain and discomfort. It also can ease muscle soreness after a workout, help you sleep better, and combat bloating. If those aren't enough benefits for you, in an animal study, curcumin was shown to prevent fat tissue growth. There's also a parallel between curcumin and the prevention of cardiovascular diseases, diabetes management, and protection from cancer, and it can be used as a therapeutic aid with gastrointestinal issues, like ulcerative colitis.

Turmeric could improve memory
The Chronicle Herald, March 2018
A new study published late January in the American Journal of Geriatric Psychiatry investigated the effect of a highly-absorbable curcumin supplement on the memory of healthy people with mild memory complaints. This study also examined the effect of this curcumin supplement on the plaques and tangles which form in the brains of people with Alzheimer’s disease. This study was small with just 40 subjects between the ages of 50 to 90 years old. All study participants were randomly given either daily placebo or a highly- absorbable curcumin supplement over the course of the 18-month study. By the end of the 18-month study, the people who took the curcumin supplement were found to have improved memory and mood compared to those who took the placebo. The memory tests administered by the researchers at the study’s end showed a 28 per cent improvement in those taking the curcumin supplement, compared to those taking placebo. Additionally, Positron emission tomography (PET) brain scans performed at the end of the study showed a significant reduction in amyloid and tau signals in the amygdala and hypothalamus of the participants who took the curcumin supplement, compared to those who took the placebo. These two markers are important indicators of brain health and risk of developing Alzheimer’s.

What does the evidence say about turmeric's health benefits?
ABC, March 2018
It's not the spice itself that's key, rather it's an active compound within turmeric called curcumin. Research has found that curcumin has some anti-oxidant and anti-inflammatory properties. "Curcumin is a very powerful anti-inflammatory agent," said Professor Manohar Garg, director of the nutraceuticals research program at the University of Newcastle. Because inflammation is linked to a range of chronic conditions and diseases, among them arthritis, Alzheimer's and heart disease, researchers argue curcumin could help reduce the risk of those diseases by limiting inflammation in the body. "It's very powerful, the most powerful food I know of, for fighting inflammation in the body," Professor Garg said. Research conducted by the professor and his team found those people taking a combination of curcumin and a phytosterol (a naturally occurring steroid found in plants) reduced their cholesterol levels over a four-week period compared to a group who received a placebo. "There's some cholesterol-lowering effect from curcumin, and some cholesterol-lowering effect from phytosterols, but if you combine them together it's a synergistic effect. It's beyond what you expect from the two compounds separately," Professor Garg said. Other research into curcumin has focused on its potential to improve cognitive function, particularly in older people. The researchers found those in the group given curcumin supplements had better working memory and an improved mood while taking the cognitive tests over a 28-day period. Professor Scholey said it was possible the curcumin was improving blood flow to the brain in those who took the supplements. "There is some work showing that curcumin can improve what's called endothelial function — that refers to the cells that line blood vessels, which can be in various degrees of elasticity or stiffness," Professor Scholey said.

Curcumin May Reverse Memory Problems, Improve Mood
Forbes, March 2018
Memory function of those who’d taken curcumin improved by 28% on average over the 18 months. In contrast, the control group's scores rose slightly (possibly because they got more familiar with the tests) and then declined. The depression scores of those taking curcumin also improved; the control group's didn't change. And interestingly, brain scans revealed significantly less amyloid and tau accumulation in two brain regions of the participants taking curcumin—the amygdala and hypothalamus, which control anxiety, memory, decision-making, and emotion.

Best Foods That Could Calm The Symptoms Of Acid Reflux
Inquisitr, March 2018
Turmeric contains anti-inflammatory and antioxidant properties. It also has curcumin, which is its most active ingredient. It is known that curcumin has antibacterial and anticancer properties. In a 2007 study, it indicated that GERD should be treated with antioxidants and anti-inflammatories. In another study, it suggested that curcumin with its anti-inflammatory effects could prevent esophageal inflammation.

Indian spice may help improve memory
WNYT, March 2018
The spice turmeric, commonly used in Indian food, may help to improve memory. It's actually a compound within the spice called curcumin. Researchers at UCLA looked at 40 older adults with mild memory problems. Patients who took curcumin tablets for 18 months scored higher on memory tests and had fewer brain plaques than those who took a placebo. The curcumin group also reported small improvements in mood. Experts believe curcumin may reduce brain inflammation, which has been linked to Alzheimer's disease and depression.

New Study Shows Turmeric May Improve Brain Health
Cooking Light, March 2018
Curcumin, the bright yellow polyphenol compound found in turmeric, has been the focus of research due to its potential to prevent chronic diseases such as cancer, heart disease, arthritis, diabetes, and Alzheimer’s disease. Clinical studies support curcumin’s anti-inflammatory and antioxidant effects on obesity and associated inflammation, leading to outcomes such as weight loss, improved blood lipids, reduced risk of atherosclerosis, and improved insulin sensitivity. Daily consumption of curcumin has been shown to improve memory and mood in people with mild, age-related memory loss, according to a study by UCLA that was recently published in the American Journal of Geriatric Psychiatry. Researchers examined the effects of curcumin supplements in people ages 51-84 who had mild memory complaints, but no dementia, as well as those ages 51-84 who were diagnosed with Alzheimer's disease. Participants took either a placebo or 90 milligrams of curcumin two times a day for 18 months. At the end of the experiment, PET scans determined those who took curcumin experienced significant improvement in their memory, mood, attention span, while those who took the placebo did not experience any of these positive effects. Researchers have identified chronic infections and inflammation as major risk factors for various types of cancer. As such, regular consumption of turmeric has been touted as a possible contributor to lower cancer rates. Results from several studies suggest that curcumin may reduce tumor promotion, block cell transformation, and minimize the spread of certain types of cancer. Curcumin’s role in the treatment of arthritis also shows promise. Studies show that patients supplementing with curcumin had reduced arthritis pain and swelling due to the inhibition of COX-2 activity. This is typically what NSAIDs are prescribed for.

Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues
Biologists.org March 2018
Curcumin, the main curcuminoid of turmeric, is a complex molecule possessing wide-ranging biological activities, cellular mechanisms and roles in potential therapeutic treatment, including Alzheimer's disease and cancer. Here, we investigate the physiological effects and molecular targets of curcumin in Dictyostelium discoideum. We show that curcumin exerts acute effects on cell behaviour, reduces cell growth and slows multicellular development. Using in silico docking analysis, we then showed that curcumin might function through direct binding to a key regulatory region of PsrA. These findings reveal novel cellular and molecular mechanisms for the function of curcumin and related compounds.

Is Turmeric Good For You? Science Says It Can Improve Your Memory, So Eat Up
Elite Daily, March 2018
Curcumin and turmeric are sometimes used interchangeably, but they actually aren’t the same thing. Turmeric is a spice, while curcumin is a chemical compound that is found in turmeric. In other words, curcumin can be taken separately from turmeric in supplement form, but turmeric doesn’t exist without curcumin. For example, in addition to improving memory, turmeric yields a decent amount of medicinal properties. According to Healthline, curcumin is also a strong antioxidant and contains anti-inflammatory properties. It also has been noted to potentially prevent heart disease by strengthening blood vessel lining.

Curcumin May Help Improve Memory: Other Potential Health Benefits Of This Turmeric Compound
Tech Times, March 2018
The researchers found less signals of tau and amyloid proteins in those who were given curcumin supplements. These proteins are linked to the development of Alzheimer's Disease. "Exactly how curcumin may exert cognitive and mood effects is not certain, but several potential mechanisms could explain our findings," researchers wrote in their study. "Curcumin reduces inflammation, and heightened brain inflammation has been linked to both Alzheimer disease and major depression." Countries such as India, where people eat curcumin at levels of about 100 mg to 200 mg a day over long periods of time, have low prevalence of cancer. Researchers suspect this may have something to do with the health benefits of turmeric. Earlier studies have shown other possible beneficial effects of consuming curcumin on health. In a 2001 study involving patients with precancerous changes, investigators found that curcumin could stop precancerous changes in organs from developing into cancer. "Our results also suggest a biologic effect of curcumin in the chemoprevention of cancer," the researchers wrote in their study. Lab tests also showed that turmeric extract that contains curcumin may help stabilize colorectal cancer that did not benefit from other forms of treatment.

Study says Increase your memory and mood by eating turmeric
Week Facts, March 2018
Found in turmeric, curcumin is hailed as a mitigating with cancer prevention agent properties, and it has additionally been recommended as a conceivable reason that senior residents in India – where curcumin is to some degree a staple – have bring down rates of Alzheimer’s malady and better psychological execution. The examination directed by the University of California Los Angeles set out to inspect the impacts of the fixing on individuals with mellow, age-related memory misfortune. “Precisely how curcumin applies its belongings isn’t sure, however it might be because of its capacity to lessen mind aggravation, which has been connected to both Alzheimer’s ailment and real sorrow,” said Dr. Gary Small.

Is Turmeric an Effective Treatment for Endometriosis?
Medical News Bulletin, March 2018
The spice turmeric, which contains the polyphenol curcumin, has long been thought to contain antioxidant and strong anti-inflammatory properties. However, few studies have investigated the effects of curcumin on endometriosis. In a recent study published in Biomedicine & Pharmacotherapy, researchers from Iran reviewed the effects. Studies Show Curcumin as Generally Safe and Effective The limited in-vitro and animal studies indicate that curcumin can reduce inflammation by suppressing inflammatory cytokine expression. In addition, there is some evidence that curcumin may reduce the disease progression by inhibiting the invasion, attachment, and angiogenesis of endometrial lesions. Curcumin is generally recognized as safe to use by the US Food and Drug Administration, and studies have demonstrated its safety up to at least 15 mg per day.

Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression
Obesity, March 2018
Curcumin intervention reduced WAT macrophage infiltration and altered macrophage functional polarity, as the ratio of M2-like versus M1-like macrophages increased after curcumin intervention. Curcumin treatment reduced M1-like macrophage markers or proinflammation cytokine expression in both macrophages and adipocytes. Curcumin intervention also increased energy expenditure and body temperature in response to a cold challenge. Finally, the in vivo and in vitro investigations suggested that curcumin increased expression of uncoupling protein 1 (UCP1), possibly involving PPAR-dependent and -independent mechanisms. Curcumin intervention targets both WAT inflammation and BAT UCP1 expression. These observations advanced our knowledge on the metabolic beneficial effects of the curry compound curcumin, bringing us a novel perspective on dietary polyphenol research.

Molecular targets of Curcumin
Advances in Experimental Medicine and Biology, March 2018
Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive-oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase, and inducible nitric oxide synthase (iNOS); it is an effective inducer of heme oxygenase-1. t has been demonstrated that curcumin- induced apoptosis is mediated through the impairment of the ubiquitin–proteasome pathway.

Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes
Academic.oup.com, March 2018
It was concluded that curcumin supplementation enhanced the resistance of broilers to heat stress, as evidenced by reversing the FC, increasing the GSH content and GSH-related enzyme activities, and inducing the expression of Nrf2 and Nrf2-mediated phase II detoxifying enzyme genes.

Dietary curcumin may boost egg quality, hen health
Feed Navigator.com, March 2018
We can conclude that curcumin added in the diet of laying hens was able to increase egg antioxidant levels, as well as to reduce lipid peroxidation in fresh and stored eggs, contributing to the improvement of egg quality. Moreover, the curcumin exerted beneficial effects on an animal health by stimulating the immune response and controlling coccidiosis.

Dietary curcumin may boost fish survival, performance
Feed Navigator.com, March 2018
Our results demonstrated that curcumin dietary supplement exerts potent bactericidal action against S. agalactiae, presenting 100% of therapeutic efficacy when compared to infected and non-supplemented animals. Also, the treatment prevented the occurrence of clinical signs of disease.

The Surprising Health Benefit Hiding In Turmeric, The bright yellow spice may help protect your brain, a new study finds
Mens Health, February 2018
At the end of the study, the curcumin group experienced a 28 percent improvement in their memory tests, while those popping the placebo didn’t see a significant change. What’s more, they also saw a slight boost in their mood compared to the placebo poppers. The researchers can’t say exactly why curcumin might have these effects. But after analyzing the brain scans, they noticed that people taking curcumin had lower levels of both abnormal proteins, specifically in areas of the brain that influence memory and emotion. Plus, curcumin is an antioxidant that might fight inflammation, explains study author Gary W. Small, M.D., director of the UCLA Longevity Center. The more inflammation you have in your brain, the more likely you are to experience cognitive problems and depression, he says.

Curcumin May Reverse Memory Problems, Improve Mood
Forbes,  February 2018
With more and more of the aging population affected by Alzheimer's disease, and clinical trials for new medications often providing underwhelming results, a new study in The American Journal of Geriatric Psychiatry may be especially promising. It finds that taking a daily dose of curcumin, the compound in turmeric root that gives curry its yellow color, may not only prevent memory problems from worsening over time, but actually improve them. And perhaps most noteworthy, these changes were seen not only in the participants' cognitive capacities, but also in their brain cells. It turned out that the memory function of those who’d taken curcumin improved by 28% on average over the 18 months. In contrast, the control group's scores rose slightly (possibly because they got more familiar with the tests) and then declined. The depression scores of those taking curcumin also improved; the control group's didn't change. And interestingly, brain scans revealed significantly less amyloid and tau accumulation in two brain regions of the participants taking curcumin—the amygdala and hypothalamus, which control anxiety, memory, decision-making, and emotion.

Is Turmeric Beneficial to Everyone? Dr. David Samadi Explains.
Reporter Expert,  February 2018
Renowned surgeon David Samadi is enthusiastic about people using turmeric to improve their own health. Dr. Samadi is the chairman of urology and the chief of robotic surgery at New York City’s Lenox Hill Hospital. He is a world leader in using cutting-edge technology to treat cancer patients. At the same time, he is passionate about educating people about what they can do for themselves to live a healthy and vibrant life. To that end, he makes frequent appearances in the media to spread his knowledge to as many people as possible. Dr. Samadi is a member of the Medical A-Team on Fox News and is the chief medical correspondent on AM 970, a popular radio station serving the New York City metropolitan area. According to Dr. Samadi, turmeric may be helpful in treating or preventing arthritis, inflammatory bowel disease, Alzheimer’s disease, cancer and depression. He explains the science behind turmeric’s beneficial effects in treating the following common conditions: Arthritis Studies show that curcumin, the active ingredient in turmeric that has anti-inflammatory properties, can help relieve the pain caused by joint inflammation. Inflammatory Bowel Disease Studies show that curcumin lowers the rate of relapse for people suffering from ulcerative colitis, which is a chronic form of inflammatory bowel disease. Alzheimer’s Disease Research shows promising results in using turmeric to help slow down the progression of this terrible disease. Scientists believe that curcumin may help destroy the plaque that causes Alzheimer’s patients to lose cognitive function. Countries where turmeric is frequently used in cooking have lower rates of Alzheimer’s disease. Cancer Research shows that curcumin may help reduce the spread of tumors in patients who have pancreatic and some other types of cancer. It is not a stand-alone treatment, but it may be useful as a supplement to other forms of treatment. Depression Several studies have shown that curcumin can help reduce the symptoms of depression. How to Use Turmeric for Your Health If you are not used to cooking with turmeric, you may wonder how to incorporate it into your daily life. You can buy turmeric as a whole root or in dried and powdered form. Both are good, but the dried form has a higher concentration of curcumin, the component of turmeric most often studied for its anti-inflammatory health benefits. Dr. David Samadi points out that a standard dosage of turmeric hasn’t been established. However, he suggests that one to three grams per day of the dried form of turmeric is probably enough. How to Maximize the Absorption of Curcumin Dr. Samadi suggests that you consume turmeric when you are eating a meal. Taking turmeric with food helps your body better absorb the curcumin in the turmeric. You can help ensure you are absorbing the maximum amount by ingesting turmeric while you are eating a meal that contains healthy fats. These fats include fish oil, olive oil, avocado oil, coconut oil, nuts and seeds.

Turmeric Compound Boosts Cognitive Power, Reveals New Study
Sci-News,  February 2018
Curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance. “The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not,” Dr. Small said. “In memory tests, the people taking curcumin improved by 28% over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.”

Curcumin limits weight gain.
Journal of Applied Physiology,  February 2018
We investigated the effect of curcumin, a naturally occurring polyphenol known for its anti-inflammatory properties and inhibitory action on 11β-HSD1 activity, on preserving metabolic health and limiting adipose tissue growth following the cessation of daily exercise and caloric restriction (CR). Cessation of daily CR and exercise caused an increase in body mass, as well as a 9- to 14-fold increase in epididymal, perirenal, and inguinal adipose tissue mass, all of which were attenuated by curcumin ( P < 0.05). Insulin area under the curve (AUC) during an oral glucose tolerance test, HOMA-IR, and C-reactive protein (CRP) were elevated 6-, 9-, and 2-fold, respectively, in the Detrained + Placebo group vs. the Trained group (all P < 0.05). Curcumin reduced insulin AUC, HOMA-IR, and CRP vs. the placebo group (all P < 0.05). Our results indicate that curcumin has a protective effect against weight regain and impaired metabolic control following a successful period of weight loss through diet and exercise, perhaps via inhibition of glucocorticoid action and inflammation.

Lowering your risk of Alzheimer's disease
Express,  February 2018
Memory loss could also be prevented by eating more curry, scientists have claimed. The spice curcumin - which gives curry its bright colour - could boost patients' mood and memory. Eating curcumin everyday for 18 months improved memory by 28 per cent, a study claimed.

Natural supplements that you should be taking every day
Blasting News,  February 2018
Turmeric -- The spice that gives curry that yellow coloring. This powerful herb's main ingredient is curcumin, a natural anti-inflammatory which the body needs to fight off bacteria that are harmful. Along with the increased production of antioxidants and a great way to fight heart disease, another important benefit of taking Turmeric is the growth hormone called Brain-Derived Neurotrophic Factor. According to the US National Library of Medicine, decreased levels of BDNF can lead to brain disease and decreased functions in the brain. Curcumin can increase levels of BDNF, which can delay or even reverse many brain diseases or age-related decreases in brain function. You will want to add this to your supplement routine, as curcumin makes up only three percent of Turmeric, so taking it as a supplement is better.

Curcumin Improves Mood and Memory
Doctor Oz,  February 2018
UCLA researchers find consumption of curcumin helps mood and memory. Forty adults with mild memory complaints were randomly selected to ingest curcumin twice daily or a placebo for 18 months. They underwent cognitive assessments and PET scans to test amyloid in the brain, which is associated with negative effects on memory and emotional functions. Those taking curcumin improved their memory tests by twenty-eight percent, demonstrated mild mood improvements, and showed far smaller levels of amyloid than the placebo group. A follow-up study will explore the possibility of curcumin possessing antidepressant effects and whether it can help your genetic risk for Alzheimer’s. These findings back up the far lower rate of Alzheimer’s in India’s senior citizens, whose diet is high in curcumin.

Curry Ingredient May Improve Memory
GKMan,  February 2018
Participants who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not. Therefore it has been proven that curcumin can contribute to the improvement of memory and disposition of people suffering from moderate memory loss cause by aging. A new study has been published, confirming that curcumin, the chemical that gives curry its intense yellow color, has important health benefits, in the context of long-term consumption.

The healing power of turmeric: Curcumin may lower Alzheimer’s disease risk by boosting memory and mood
Times Now News,  February 2018
Earlier, a report published in the British Medical Journal Case Reports, noted that a 57-year-old woman, who was diagnosed with blood cancer in 2007 after complaining of high blood pressure, curcumin helped her recover from the deadly condition after conventional medicine failed to work on her body. The report said the woman started taking 8g of curcumin a day - one of the main compounds in turmeric - as a last resort after research online. With no further treatment, over the last five years, doctors said her cancer had remained stable and her blood counts are within the normal range with daily curcumin. The findings revealed that people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not. Turmeric is one of the most traditional and versatile of spices used in Indian cooking. It has been suggested as a possible reason that senior citizens in India have a lower prevalence of Alzheimer’s and better cognitive performance.

Curcumin's Anti-Inflammatory Properties Might Improve Memory, Attention
Ask Men,  February 2018
Turmeric is on a tear right now. In recent years it’s been connected to everything from healthier skin to helping control pain and inflammation. But new research suggests it can also aid with memory and happiness. The paper, published last week in the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed supplement of curcumin — the substance that gives turmeric its bright orange colour — on the performance of memory in people without dementia. The study also looked at curcumin’s potential impact on the microscopic plaques and tangles that occur in the brains of those with Alzheimer’s disease. The heavy use of turmeric in cooking has already been raised as a possible reason for the lower rates of Alzheimer’s disease and better cognitive performances among senior citizens in India compared to the rest of the world. Why? Most likely because of its capacity to reduce brain inflammation, “which has been linked to both Alzheimer’s disease and major depression,” said the study’s author, Doctor Gary Small of UCLA, in a news release. The study involved a double-blind, placebo-controlled group of 40 adults between ages 50 and 90. They were Alzheimer’s and dementia free, but all reported mild memory complaints. The participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months. They were then monitored at six month intervals throughout the test using a standardized cognitive assessment. After 18 months, those who had been taking curcumin were reporting significant improvements in memory and attention abilities. On average, their memory tests improved by a whopping 28%. The curcumin takers also reported a slight improvement in mood when compared to those on the placebo.

Striking with the Root: Turmeric Curcumin and Ulcerative Colitis
Care2,  February 2018
Despite evidence going back 40 years that the turmeric spice component curcumin possesses significant anti-inflammatory activity, it wasn’t until 2005 that it was first tested on inflammatory bowel disease. Why did it take so long? Well, who’s going to fund such a study? Big curry? Even without corporate backing, individual physicians from New York decided to ask the next five patients with ulcerative colitis who walked through their office doors to start curcumin supplements. And, researchers obliged. They took a bunch of people with quiescent ulcerative colitis and gave them either turmeric curcumin along with their typical anti-inflammatory drugs, or a placebo and their drugs. In the placebo group, 8 out of 39 patients relapsed, meaning their disease flared back up. In the curcumin group, however, only 2 out of 43 relapsed, significantly fewer. And, relapse or not, clinically, the placebo group got worse, while the curcumin group got better. Endoscopically, which is objectively visualizing the inside of their colons, doctors saw the same thing: a trend towards worse or better. The results were stunning: a 5 percent relapse rate in the curcumin group compared with a 20 percent relapse rate in the conventional care group. It was such a dramatic difference that the researchers wondered if it was some kind of fluke. Even though patients were randomized to each group, perhaps the curcumin group just ended up being much healthier through some chance coincidence, so maybe it was some freak occurrence rather than curcumin that accounted for the results. So, the researchers extended the study for another six months but put everyone on the placebo to ensure the initial findings were not some aberration. The curcumin was stopped to see if that group would then start relapsing, too—and that’s exactly what happened. Suddenly, they became just as bad as the original placebo group. The researchers concluded: “Curcumin seems to be a promising and safe medication for maintaining remission in patients with quiescent ulcerative colitis.” Indeed, no side effects were reported at all. So, “Curry for the cure?” asked an accompanying editorial in the journal of the Crohn’s and Colitis Foundation of America. “Can curcumin be added to our list of options with respect to maintaining remission in ulcerative colitis? What is noteworthy about this trial is the fact that not only did the authors demonstrate a statistically significant decrease in relapse at 6 months, but a statistically significant improvement in the endoscopic index as well. Equally telling is the fact that upon withdrawal of curcumin the relapse rate quickly paralleled that of patients treated initially with placebo, implying that curcumin was, in fact, exerting some important biologic effect.” Similarly, a Cochrane review concluded in 2013 that curcumin may be a safe and effective adjunct therapy.

Curcumin Shown to Improve Memory
Whole Foods Magazine,  February 2018
Results of the study are as follows: Memory function of those who’d taken curcumin improved by 28% on average over the 18 months. In contrast, the control group’s scores rose slightly (possibly because they got more familiar with the tests) and then declined. The depression scores of those taking curcumin also improved; the control group’s didn’t change. Brain scans revealed significantly less amyloid and tau accumulation in two brain regions of the participants taking curcumin — the amygdala and hypothalamus, which control anxiety, memory, decision-making, and emotion.

Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury
Molecules,  February 2018
Curcumin pre-treatment significantly decreased CCl4-induced inflammation. Furthermore, curcumin pre-treatment significantly down-regulated the expression of TGF-β1 and Smad3 mRNAs (both p < 0.01), and up-regulated the expression of nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p < 0.01) in the liver. Inhibition of HO-1 attenuated the protective effect of curcumin on CCl4-induced acute liver injury. Given these outcomes, curcumin could protect against CCl4-induced acute liver injury by inhibiting oxidative stress and inflammation, which may partly involve the activation of Nrf2/HO-1 and inhibition of TGF-β1/Smad3 pathways.

Curcumin ‘improves mood and memory
Health Spectator,  February 2018
Daily consumption of curcumin improves the memory and mood of people with mild, age-related memory loss, according to a new study by the University of California, Los Angeles. The research, which has been published the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed curcumin supplement on memory performance in people without dementia, as well as curcumin’s impact on the microscopic plaques and tangles in the brains of people with Alzheimer’s. Found in turmeric, curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s and better cognitive performance. The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not. In memory tests, the people taking curcumin improved by 28 per cent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.

How turmeric can help treat irritable bowel syndrome (IBS)
The Health Site,  February 2018
The active ingredient in the spice, curcumin, has a laundry list of health benefits. A recent case study in the BMJ showed how a cancer-stricken 57-year-old woman who was given only a few months to live cured herself with turmeric. Currently, there is enough evidence to make a case for turmeric as complementary therapy also for irritable bowel syndrome or IBS. The beneficial effects of turmeric on IBS could be attributed to its anti-inflammatory, antioxidant, antibacterial and spasmolytic effects. Another 2010 study conducted on animals showed that curcumin in the turmeric could be beneficial in curbing stomach disorders such as diarrhoea, cramps and IBS.

How a Nutritionist Uses Turmeric For Health
Pop Sugar,  February 2018
Research published in the journal Oncogene found that turmeric is actually a more effective anti-inflammatory than over-the-counter pain relievers like aspirin and ibuprofen. ADVERTISEMENT This is a modal window. The media could not be loaded, either because the server or network failed or because the format is not supported. Turmeric can also be used to increase levels of brain-derived neurotrophic factor (BDNF), which is a growth hormone in the brain that, when low, is responsible for increased risk of Alzheimer's disease, depression, and a host of other mental ailments. The curcumin in turmeric has also been proven to reverse symptoms of heart disease. Many other studies have found a parallel function and effect of the substance on your heart as compared to exercise.

Health benefits of turmeric
Philstar,  February 2018
Antidepressants. Curcumin the main substance in turmeric may be used as an effective and safe therapy for treatment in patients with mild depression. Arthritis management. Because curcumin is known for its powerful anti-inflammatory and pain-reducing characteristics, it has an amazing effects on people suffering from various types of arthritis. Cancer treatment. A number of laboratory studies on cancer cells have shown that curcumin does have anticancer effects. It seems to be able to kill cancer cells and prevent more from growing. It has the best effects on breast cancer, bowel cancer, stomach cancer, and skin cancer cells. Diabetes management. For lowering blood sugar and reversing insulin resistance, there’s arguably no better natural treatment than adding turmeric into your diet. Obesity. A study published in the journal “Biofactors” showed that curcumin can help promote weight loss. The researchers found that the anti- inflammatory properties in curcumin were effective at suppressing the inflammatory process of obesity, therefore helping to reduce obesity and its “adverse health effects.” Cholesterol regulators. One of the reasons heart disease is such a problem in the U.S. is that people are developing pre-diabetes (high blood sugar) at an alarming rate. A study done by “Drugs in R & D found that curcumin was equal, or more effective than diabetes medication at reducing oxidative stress and inflammation in the treatment of high cholesterol. Painkillers. One of the more widely accepted properties of curcumin in scientific communities is its ability to manage pain. Therapeutic use of turmeric and other curcumin-rich plants are displacing conventional medical treatments and proving it’s a legitimate natural pain killer.

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy
Medical Sciences,  February 2018
Curcumin (diferuloylmethane), the natural polyphenol responsible for the characteristic yellow pigment of the spice turmeric (Curcuma longa), is traditionally known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression of carcinogenesis through multiple mechanisms, curcumin has potential utility for both chemoprevention and chemotherapy. In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues. Numerous studies have demonstrated that pretreatment with curcumin can abrogate carcinogen-induced ODC activity and tumor development in rodent tumorigenesis models targeting various organs. This review summarizes the results of curcumin exposure with regard to the modulation of polyamine metabolism and discusses the potential utility of this natural compound in conjunction with the exploitation of dysregulated polyamine metabolism in chemopreventive and chemotherapeutic settings.

Supplements That Enhance Detoxification
Newsmax,  February 2018
Curcumin, quercetin, hesperidin, ellagic acid, naringenin and other flavonoids enhance phase II detoxification. They also protect liver cells and other tissues and organs. They are all powerful antioxidants and more versatile than the antioxidant vitamins.

Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer
Oncology Reports,  February 2018
Curcumin is known to exhibit anticancer effects on various cancers with selective cytotoxicity in tumor cells. Our results showed that curcumin inhibited the viability of A549 cells time‑ and dose‑dependently. In addition, a dosage-dependent A549 cell apoptosis‑induction phenomena was observed by the curcumin intervention. Moreover, obvious autophagy was induced after curcumin‑treatment, characterized by the formation of fluorescent particles [autophagic vesicles (AVs)] and significant increase in ratio of LC3‑Ⅱ/LC3‑Ⅰ and Beclin1 as well as decreased p62 expression. Furthermore, the effect of curcumin on a substantial downregulation of phosphatidylinositol 3‑kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was observed. It is worth noting that the inhibition of mTOR by rapamycin or of PI3K/Akt by LY294002 augmented curcumin‑induced apoptosis and autophagy, leading to significant inhibition of cell proliferation. From these findings, it can be speculated that curcumin potently inhibit the cell growth of NSCLC A549 cells through inducing both apoptosis and autophagy by inhibition of the PI3K/Akt/mTOR pathway. These results support the potential use of curcumin as a novel candidate in treatment of human lung cancer.

Diabetes and Obesity Linked to Higher Cancer Risk: 4 Foods That Reduce This Risk
NDTV,  February 2018
Turmeric: The principle component of turmeric is curcumin which is a potent antioxidant scavenging free radicals and inhibiting the growth of cancerous cells. Almost 2000 published scientific papers have shown that curcumin has the ability to kill cancer cells while not harming the healthy cells.

Curcumin Protects against Atherosclerosis
Journal of Agricultural and Food Chemistry,  February 2018
Curcumin supplementation significantly reduced TLR4 expression and macrophage infiltration in atherosclerotic plaques. Curcumin also reduced aortic interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-κB (NF-κB) activity, and plasma IL-1β, TNF-α, soluble VCAM-1 and ICAM-1 levels. In addition, aortic sinus sections revealed that curcumin treatment reduced the extent of atherosclerotic lesions and inhibited atherosclerosis development. In vitro, curcumin inhibited NF-κB activation in macrophages and reduced TLR4 expression induced by lipopolysaccharide. Our results indicate that curcumin protects against atherosclerosis at least partially by inhibiting TLR4 expression and its related inflammatory reaction

Turmeric pills help woman survive blood cancer
Los Angeles Times, January 2018
In 2011, Ferguson decided to take daily supplements of curcumin, the beneficial compound in turmeric, every night. A couple of months after she began the regimen, she started on a weekly course of hyperbaric oxygen therapy. The non-traditional treatment involves breathing in pure oxygen from an enclosed chamber with specific atmospheric pressure adjustments. Since then, Ferguson's cancer has remained stable and her blood counts are within a safe and normal range. Of course, due to the close proximity of her introduction of turmeric and the hyperbaric oxygen therapy, it's uncertain whether it was the turmeric that cured the progression of her disease. "The fact that our patient, who had advanced stage disease and was effectively salvaged while exclusively on curcumin, suggests a potential antimyeloma effect," the report concludes. "We would recommend further evaluation of curcumin in myeloma patients in the context of a clinical trial."

British Woman Beats Rare Cancer With 2 Teaspoons Of This Per Day
The Alternative Daily, January 2018
Ferguson decided to try treating herself with a “golden spice” called curcumin, which is a naturally occurring chemical compound in the herb turmeric after she had heard about how another woman (named Margaret) had used it successfully to treat her myeloma. Ferguson began taking eight grams (about two teaspoons) of curcumin per day for about five years. As a result, she is now vastly improved to the point where her cancer count is considered both manageable and negligible. Jamie Cavenagh, professor of blood diseases at London’s Barts Hospital, who has subsequently co-authored a report on Ferguson’s case, believes curcumin was a decisive part of her amazing recovery. As Cavenagh explains, “When you review her chart, there’s no alternative explanation for her recovery other than we’re seeing a response to curcumin.” Dr. Abbas Zaidi, a hematologist at Barts NHS Health Trust, who contributed to the report on Ferguson, also believes that curcumin played an important role in her improvement.

Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”
Journal of Neuroinflammation, January 2018
Oral administration of curcumin restored the imbalance between the sympathetic and parasympathetic tones in CIA rats and increased ChAT activity and expression of ChAT and VAChT in the gut, brain, and synovium. Additionally, VGX eliminated the effects of curcumin on arthritis and ACh biosynthesis and transport. Electrophysiological data showed that curcumin markedly increased neuronal excitability of the vagus nerve. Furthermore, selective α7 nAChR antagonists abolished the effects of curcumin on CIA. Our results demonstrate that curcumin attenuates CIA through the “gut-brain axis” by modulating the function of the cholinergic system. These findings provide a novel approach for mechanistic studies of anti-arthritic compounds with low oral absorption and bioavailability.

Healing foods
Navhindtimes.in January 2018
Curcumin is a powerful antioxidant with powerful anti-inflammatory effects. Studies have shown that curcumin and turmeric have antimutagenic and anticancer properties and have also been shown to be effective against Alzheimer’s disease in animal models. A glass of hot milk with a pinch of haldi is a common household remedy for a cold and sore throat. Curcumin is fat soluble and needs to be absorbed in the presence of fat. Hence haldi should be fried along with the seasonings in oil. Black pepper has also been found to increase the absorption of cucurmin. Supplements containing haldi extracts or curcumin should be taken after a meal as the fat in the meal helps in its absorption.

The miracle of turmeric: How can this golden spice help reinvigorate your health
Express, January 2018
The 67-year-old, who had battled blood cancer for five years, began taking daily doses of curcumin, one of the main compounds of turmeric. More familiar as an ingredient in curries the spice is also an ancient remedy for a variety of ailments. While this natural approach won’t work for everyone the Londoner’s cancer-cell count is now negligible. As Dieneke’s doctors hail the remarkable results we take a look at turmeric and the ways in which it may boost health. The spice, recognisable by its golden colour, is ground from the dried root of a plant called Curcuma longa. A relative of ginger it thrives in warm, moist conditions and has long been used as a medicine in Chinese and Indian cultures. Turmeric’s healing powers are attributed to phytochemicals, compounds which are present in many plants. Curcumin, which is found in turmeric, is claimed to be one of the most powerful remedies in nature’s medicine cabinet. Another benefit of turmeric may be combating depression, stress and anxiety. It is claimed curcumin can be used as a natural alternative to drugs such as Prozac, working by inhibiting an enzyme in the brain that is responsible for depression. There may be a double whammy as it is claimed curcumin can also increase levels of serotonin and dopamine – chemicals that boost happiness. The powers of curcumin could even extend to improving the sex life of men by improving blood flow to the genitals.

Wonder curry spice could be used to treat cancer after stunning doctors
Leicester Mercury, January 2018
Ms Ferguson began taking 8 grams of curcumin - one of the main compounds in turmeric - each day in tablet form. It’s the equivalent of about two teaspoons. Her illness has an average survival of just over five years - making it one of the most fatal forms of the disease. It was rapidly spreading - causing increasing back pain - and she had already had a second relapse. Dr Abbas Zaidi, a haematologist at Barts NHS Health Trust, said: "Here we describe a myeloma patient who started a daily dietary supplement of curcumin when approaching her third relapse. "In the absence of further antimyeloma treatment the patient plateaued and has remained stable for the last five years with good quality of life." The remarkable improvement described in BMJ Case Reports follows previous research into the health benefits of turmeric which is packed with antioxidants.

Cancer patient, 67, ‘beats the disease with the help of TURMERIC’ after five years of chemo failed
The Sun, January 2018
In 2011 she began taking daily doses of curcumin, a key component of the spice turmeric, after another two rounds of stem cell therapy failed. Dieneke took eight grams of curcumin each night on an empty stomach. Dieneke took eight grams of turmeric every night and her blood cancer stabilised. Over the last five years her cancer has remained stable and her blood counts are within the normal range, doctors report. She has also maintained a good quality of life during this period, according to the report. Curcumin is a micronutrient derived from the herb turmeric, and has been used as a traditional Indian medicine for centuries.

Foods That Can Help You Prevent from Getting Cancer
Your Health Mag, January 2018
Curcumin, a major component of curry, contains curcumin, which blocks or reduces tumors.

Woman Halts Cancer in Its Tracks With Turmeric
Metro, January 2018
She took 8g of turmeric tablets every day for years without further treatment, and has now shocked doctors. ‘To the best of our knowledge, this is the first report in which curcumin has demonstrated an objective response in progressive disease in the absence of conventional treatment,’ her doctors, from Barts Health NHS Trust in London, wrote in the British Medical Journal Case Reports. ‘In the absence of further antimyeloma treatment the patient plateaued and has remained stable for the past five years with good quality of life.’ Turmeric is widely used in Asian cuisine and helps create distinctive colour in curries – but it would be impossible to cure myeloma with regular cooking turmeric. It would be impossible to treat cancer with regular kitchen turmeric, as it contains just 2% curcumin.

What is curcumin? Brit woman claims the wonder spice halted incurable blood cancer for a decade
International Business Times, January 2018
Dieneke Ferguson said she takes 8gram curcumin every day in a tablet form to fight the incurable myeloma. After all other treatments failed, North London resident Ferguson decided to fight back and began using curcumin — a component derived from a popular Indian spice turmeric. She said she has been taking 8gram of the compound every day in a tablet form and the result has been nothing less than a miracle. "I have been on all sorts of toxic drugs and the side-effects were terrifying. At one point I lost my memory for three days, and in 2008 two of the vertebrae in my spine collapsed so I couldn't walk," the cancer survivor said, as quoted by the Daily Mail. "They injected some kind of concrete into my spine to keep it stable." Her recovery has since baffled doctors who are yet to come to a conclusion on the effectiveness of curcumin. "Here we describe a myeloma patient who started a daily dietary supplement of curcumin when approaching her third relapse. In the absence of further antimyeloma treatment the patient plateaued and has remained stable for the last five years with good quality of life," Dr Abbas Zaidi, a haematologist at Barts NHS Health Trust said in a report, which mentions that her cancer cell count is currently negligible."Curcumin is a polyphenol derived from the perennial herb turmeric and has - for centuries - been used as a traditional Indian medicine," explains Zaidi in the case study. "The biological activity of curcumin is indeed remarkable." He added that the pigment produces multiple effects through its "natural antioxidant, anti-inflammatory, antiseptic and analgesic properties"

Curcumin targets gut-brain axis in reducing inflammation, study finds
Horsetalk, January 2018
The research team from the China Pharmaceutical University in Nanjing said many studies in recent years had shown that taking curcumin by mouth eased collagen-induced arthritis. A clinical trial, they noted, had shown that curcumin was safe and effective for patients with rheumatoid arthritis. However, studies had shown that its bioavailability was poor, which raised questions about how it produced its anti-inflammatory effect. They set out to explore whether the gut-brain axis was involved in its therapeutic action. The researchers found that curcumin did indeed reduce collagen-induced arthritis through the gut-brain axis by regulating the function of the cholinergic system

Chemopreventive and Antitumor Efficacy of Curcumin in a Spontaneously Developing Hen Ovarian Cancer Model
Cancer Prevention Research, December 2017
Our results demonstrated for the first time that daily curcumin intake leads to a significant and dose-dependent reduction in spontaneous ovarian cancer incidence and tumor growth, indicating a tremendous role for curcumin as a chemopreventive strategy for ovarian cancer.

The Effect Of Curcumin On Plasma Metabolomic Profile In Atherogenic Diet Induced Rat Model Of Alzheimer’s Disease
Nutrition and Food Science, December 2017
Curcumin, a polyphenol extricated from the plant Curcuma longa, has demonstrated its remedial advantages in Alzheimer's ailment and was utilized as a positive control. Curcumin exhibited a potential therapeutic effect in high cholesterol diet induced AD.

Curcumin reverses tobacco smoke‑induced epithelial‑mesenchymal transition
Molecular Medicine Reports, December 2017
Tobacco smoke is a major risk factor for lung cancer. Epithelial‑mesenchymal transition (EMT) is decisive in cancer invasion and metastasis, and therefore promotes cancer progression. The chemopreventive effect of curcumin on carcinogenesis has been reported in vivo and in vitro. Curcumin treatment inhibited tobacco smoke‑induced MAPK/AP‑1 activation, including ERK1/2, JNK and p38 MAPK pathways, and AP‑1 proteins, and reversed EMT alterations in lung tissue. The results of the present study provide new insights into the molecular mechanisms of tobacco smoke‑associated lung cancer and may open up new avenues in the search for potential therapeutic targets in lung tumorigenesis.

Potent Remedies That Support the Liver
Care 2, December 2017
Turmeric is a potent spice with many health benefits. Recent studies show it can improve circulation, prevent cancer, reduce pain and detoxify the body. Thanks to curcumin, a bioactive compound found in turmeric, this herb helps the liver remove toxins and wastes from the body. It’s also worth mentioning that curcumin increases production of bile, and as a result improves liver function.

Exactly How Much Turmeric to Have a Day to Reap Its Anti-Inflammatory Benefits
Pop Sugar, December 2017
"Turmeric is recommended for many patients with inflammatory conditions such as Crohn's disease, ulcerative colitis, autoimmune conditions like psoriasis, rheumatoid arthritis, osteoarthritis, Parkinson's disease, Alzheimer's disease, dementia, and cancers. Curcumin is the compound found in turmeric," said Atlanta-based integrative medicine physician Dr. Bindiya Gandhi. Arguably, the most powerful aspect of curcumin is its ability to control inflammation. "The journal Oncogene published the results of a study that evaluated several anti-inflammatory compounds and found that aspirin and ibuprofen are least effective, while curcumin is among the most effective anti-inflammatory compounds in the world," said Dr. Josh Axe, DNM, CNS, DC, bestselling author of Eat Dirt. "This news should have reached every household in the world after the study was conducted, because inflammation puts people at risk for almost every disease process known to man," he said. You can find turmeric in powder culinary spice form and in its whole root form, as well as in tincture, tablets, and capsules. "A good starting dose for its anti-inflammatory benefits is 400 to 600 mg of standardised powder or curcumin turmeric extract three times a day as tolerated," Dr. Gandhi said.

Curcumin: common dietary supplement turned anti-cancer compound?
Oxford University Press, December 2017
Over the past few decades, curcumin, a common food additive, has been identified as a potential anti-inflmmatory and anti-cancer compound. Curcumin is a phenolic compound extracted from the Curcuma longa plant, and was traditionally used as a spice for improving flavor and color into dishes of various Asian countries. Curcumin’s health benefits are not a new or surprising finding — the brightly colored compound has been used in Ayurvedic medicine for centuries for its potent anti-inflammatory and anti-tumor properties — but the fundamental mechanisms underlying its anti-cancer potential still remain an active area of interrogation. Intriguingly, curcumin has been shown to sensitize multiple cancers to chemotherapy drugs, and several recent studies have reported that curcumin is able to specifically target cancer stem cells. . As suggested by other groups, not only did we demonstrate that curcumin was able to enhance the sensitivity of gemcitabine in these resistant cells, we found that curcumin was also able to inhibit the growth of cancer stem cells. In our study, we also discovered that curcumin was regulating a class of non-coding RNA called “long non-coding RNAs” (lncRNAs). LncRNA is a relatively newly discovered type of non-coding RNA — RNA which does not make protein — found to be dysregulated in most cancers. We discovered that curcumin inhibits the expression of one of the most well-known lncRNA-based oncogenes, a gene that drives cancer, called PVT1. This lncRNA drives tumor progression through the regulation of another well-recognized oncogene, called EZH2. EZH2 is one of the oncogenes known to be involved in drug resistance and is identified to be a potential drug-able target. Though the generation of specific EZH2 inhibitors remains challenging, the findings from our study indicate that curcumin could be used to inhibit the expression of EZH2, as well as the non-coding RNA that regulates EZH2. Considering that curcumin is a commonly available health supplement, it presents itself as a non-toxic compound and incredibly cost-effective compound for the potential treatment of cancer patients.

Curcumin improves diabetes mellitus‑associated cerebral infarction by increasing the expression of GLUT1 and GLUT3
Molecular Medicine Reports, December 2017
Curcumin is characterized by anti‑inflammatory, anti‑oxidative, antiviral, antifibrotic, anticoagulation and glucose regulatory functions. Curcumin markedly decreased cell apoptosis, indicating an anti‑apoptotic role of curcumin in the brain. To further evaluate whether curcumin prevented cell apoptosis by modulating the expression of GLUT1 and GLUT3, small interfering RNAs targeting GLUT1 and GLUT3 were selected. It was found that the knockdown of GLUT1 and GLUT3 inhibited the abundance of GLUT1, GLUT3 and B‑cell lymphoma 2, even following incubation with curcumin. These data showed that curcumin protected brain cells from apoptosis and cerebral infarction, predominantly by upregulating GLUT1 and GLUT3.

Natural Remedies for Tendonitis
Care 2, December 2017
An extract of the spice turmeric, which is often used in curries to give them a yellowish color, curcumin is an excellent choice in dealing with any type of inflammation. While there are few studies on its use for tendonitis, preliminary research published in the Journal of Biological Chemistry showed that curcumin has a place in the healing of tendonitis.

Curcumin Enhances the Efficacy of 5-FU in Colo205 Cell Lines
Proceedings, December 2017
Curcumin was observed to increase the efficacy of 5-FU and accelerate the cytotoxic effect by removing the cytostatic period seen in the first 6 h. The study results show that the combination of 5-FU and curcumin in Colo205 can reduce the dose by increasing the cytotoxic activity of 5-FU and reducing the resistance to the anticancer drug.

Health benefits of the humble turmeric
Hindustan Times, December 2017
Turmeric is a root that is as popular as ginger in Ayurveda. Many of its beneficial aspects are due to its active compound, curcumin. Curcumin has a profoundly anti-inflammatory effect on the body, and provides a good defence system against diseases. Inflammation is the body’s reaction to toxic elements in our environment, such as water with heavy chlorine, air pollution, unhealthy oil (trans fats), stress, lack of sleep, and overuse of chemical aromas, deodorants, cleaning agents, etc.

Can Curcumin be Employed to Promote the Integration of Oncology and Natural Products?
Proceedings, December 2017
Curcumin inhibits NF-kB activation pathway at a step before inhibitor kappa B alfa (IKBα) phosphorylation. Preclinical in vivo and in vitro trials that combine curcumin with tyrosine kinase inhibitors (TKIs) have shown that this combination shows better results than each treatment alone. Retrospectively evaluated seventeen NF-kB overexpressed cancer patients were treated with i.v. and oral bioavailable formulation of curcumin and appropriate TKIs. TKIs decision was made according to genetic profiling (FoundationOne®). Toxicities and response was evaluated according to RECIST and common toxicities criteria. All patients are stage IV and heavily pretreated. Our longest experience comes from adenoid cystic carcinoma and he has treated for 72 months by oral curcumin and 8 months by i.v curcumin. Disease control rate was 89.3% (15/17) and no any grade III-IV toxicities was observed related to curcumin. Curcumin is multitargeted molecule with pleotrophic nature. Curcumin inhibits NF-κB and related proteins which promotes effectiveness of TKIs. And might be considered as long as we have to use chemotherapy, radiotherapy and TKI.

Which spice wins for its medicinal properties?
Daily Sabah Health, December 2017
What makes turmeric, which is quite rich in iron and manganese, a key ingredient in alternative medicine is its active ingredient curcumin. Curcumin is one of the best herbs for good health due to large amounts of vitamins C and E. Turmeric is a lightened version of curcumin that can be used in kitchens. Thanks to the curcumin in it, turmeric regulates sleep patterns. It also prevents muscles from getting tired very quickly and boosts sports performance. Some studies indicate that by using turmeric, symptoms can be decreased and inflammation-related conditions, including arthritis, can be eased. Moreover, scientists have proven that consuming turmeric helps to slow down the symptoms of Alzheimer's disease. However, the signature benefit of turmeric is in the treatment of inflammation.

Curcumin, quercetin and atorvastatin protected against the hepatic fibrosis by activating AMP-activated protein kinase
Journal of Functional Foods, December 2017
Curcumin, quercetin, and atorvastatin protected against the hepatic fibrosis by reducing hepatic fat accumulation via AMPK up-regulation.

Curcumin Beats Diabetes Drug at Lowering Blood Sugar: Study
News Max, December 2017
Natural remedies, however, can be very effective,” he adds. “A large number of studies have shown that curcumin can be very helpful at decreasing blood sugar as well as the complications of diabetes.” Other studies have shown its effectiveness in treating other aspects of diabetes, both in Type 1 and Type 2 according to the Website, Diabetes Self Management. David Spero, R.N., says that research conducted by Beijing University of Chinese Medicine and McGill University showed that curcumin reduced both blood sugar and cholesterol levels. Curcumin suppressed the activities of white blood cells called macrophages that cause inflammation as well as slowed down many of the complications of diabetes, in which inflammation plays a role. Curcumin improved insulin function by helping the hormone get into the cells thus reducing insulin resistance. In a study of 240 people in Thailand, curcumin prevented prediabetes from developing into full blown diabetes. Roughly 16 percent of the people studied in the placebo group progressed to Type 2 diabetes within 9 months while nobody in the group receiving 250 milligrams of curcuminoids from supplements progressed. Curcumin protects beta cells, which produce insulin. Studies have found that beta cells grew faster and lived longer in rats who consumed curcumin. In addition to its diabetes-fighting properties turmeric has been found to be an effective anti-inflammatory — even more effective than aspirin or ibuprofen and even Celebrex without the potentially deadly side effects of these drugs. As a cancer treatment, multiple studies have shown that curcumin holds promise in fighting against skin cancer, breast cancer, bowel and stomach cancers. A 2007 study found that curcumin combined with chemotherapy killed more cancer cells than chemotherapy alone. The American Cancer Society states that curcumin interferes with the development, growth, and spread of cancer cells. Curcumin has also been shown in multiple studies to be more effective than the popular drug Zoloft to beat depression,” adds Teitelbaum. “And if that’s not enough, current research suggests it may also decrease the risk of developing Alzheimer’s disease. The only side effect reported to my knowledge is that you start feeling fantastic.”

Studies that prove Curcumin can kill at least 3 types of cancer
emaxhealth, November 2017
Lung cancer: The effects of curcumin in chronic obstructive pulmonary disease (COPD) airway inflammation and lung cancer progression, were tested in an animal model study. Scientists administered to mice, the natural anti-inflammatory agent curcumin, 1% in diet before and during weekly non-typeable Hemophilus influenzae (NTHi ) exposure, which has been associated with the pathology of COPD. It was observed that curcumin significantly reduced the number of visible lung tumors in the absence of NTHi exposure by 85% and in the presence of NTHi exposures by 53%. It is important to note that Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions, and the effect of curcumin in decreasing the migratory and invasive ability of A549 ( lung carcinoma cells) cells by inhibiting adiponectin expression is probably mediated through NF-κB/MMP pathways. Ovarian carcinoma: In vitro and in vivo experiments of curcumin with and without docetaxel (chemotherapy medication) were done using human ovarian cancer cell lines. It was observed that Curcumin inhibited inducible NF-kappaB activation and suppressed proliferation in vitro. In vivo dose-finding experiments revealed that 500 mg/kg orally was the optimal dose needed to suppress NF-kappaB and signal transducers and activators of transcription 3 activation and decrease angiogenic cytokine expression. Colorectal cancer::Cyclo-oxygenase 2 (COX2), which mediates prostaglandin synthesis during inflammation, and which is selectively overexpressed in colon tumours, is thought to play an important role in colon carcinogenesis. But, a study that tested Human colon epithelial cells (HCEC) and SW480 colon carcinoma against curcumin, concluded that curcumin inhibits COX2 induction by the colon tumour promoters, tumour necrosis factor alpha or fecapentaene-12, which are fecal mutagens that are naturally produced in the human colon and have a role in neoplastic transformation of the colon. It is important to note that curcumin, not only affects signaling of proteins like tumor necrosis factor-(TNF) or the nuclear factor NF-κB. Curcumin also blocks interleukin-1 (IL-1) signalling, which as previously mentioned has been associated with the pathology of different types cancer. Therefore, the powerful ability to interfere in the mechanisms involved in cancer, make curcumin a natural cancer killer.

Drastically Reduce Your Colon Cancer Risk
Care2.com
, November 2017
Curcumin, one of the phytonutrients found in the spice turmeric, has been found in numerous studies to reduce colon cancer risk. A study found in Cancer Prevention Research showed that curcumin suppresses the ability of colon cancer cells to proliferate, suggesting it is helpful both in the prevention and treatment of the condition.

Curcumin Exerts Effects on the Pathophysiology of Alzheimer's Disease
Frontiers in Neurology,
November 2017
Curcumin, a major polyphenol from curry spice (Curcuma longa), has been reported to inhibit Aβ aggregation, Aβ-induced inflammation, and the activities of β-secretase and acetylcholinesterase in in vitro studies (12, 13). Moreover, in in vivo studies, oral administration of curcumin has resulted in the inhibition of Aβ oligomerization, Aβ deposition, and tau phosphorylation in the brains of AD animal models, as well as led to the improvements in behavioral impairment in animal models (12). In our previous study, we found that chronic curcumin administration ameliorates Aβ1-42 induced AD-related cognitive deficits (13). However, more information underlying the mechanism should be explored. Based on these research results, we speculated that curcumin may ameliorate AD pathogenesis by regulating PI(3,5)P2 and TRPML1 expression levels. To validate it, we first detect the effects of curcumin on lysosomes and the cell viability of hippocampal HT-22 cells that treated with Aβ1-42. Sequencing technique was then used and TRPML1 was identified as the most upregulated gene that affected by curcumin. Afterward, the effects of curcumin on the autophagy-related proteins were also analyzed in vitro. Besides, we also determined that curcumin ameliorated autophagy–lysosome dysfunction by regulating PI(3,5)P2 and TRPML1 in vivo. Our study suggests that curcumin might be one of the most promising compounds for the interference of AD therapies.

Turmeric is the spice of the year
Lifestyle.ynaija.com, November 2017
Turmeric's major component is curcumin, a powerful, medicinal substance that has anti-inflammatory properties, helps fight cancer and diabetes, aids digestion, combats heart diseases, works as an anti-oxidant, works magic on the skin, reduces bloating, calms severe menstrual pain and essentially, solves more than a handful of life’s problems. Turmeric tea has potential to ease health conditions such as Alzheimers, athritis, obesity and chest pain. Its anti-inflammatory properties help boost the immune system and protect the brain. Its principal component, curcumin also contains anticancer properties and has been found useful in the treatment of brain, bone and breast cancer.

The anti-inflammatory activity of curcumin
Journal of Biological Chemistry, November 2017
The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory remedy in traditional Asian medicine for centuries. Many cellular targets of curcumin have been identified, but how such a wide range of targets can be affected by a single compound is unclear. We conclude that the paradigm of metabolic bioactivation uncovered here should be considered for the evaluation and design of clinical trials of curcumin and other polyphenols of medicinal interest.

Turmeric may reduce inflammation from osteoarthritis
Daily Herald, November 2017
Over the past two decades there have been many medical studies evaluating the effect of turmeric extracts including curcumin and reducing the pain and inflammation associated with osteoarthritis. The overall results of these studies strongly indicate that curcumin and other extracts of turmeric reduce inflammation as well as pain levels in patients with osteoarthritis. A recent study published in the Journal of Medicinal Food demonstrated that extracts of turmeric have a significant impact on the inflammation and pain associated with osteoarthritis. The study was a meta-analysis, which means that it combined the data from many smaller studies and the final result indicated that an ancient spice is very effective at reducing the inflammation and associated symptoms of osteoarthritis. This meta-analysis included middle-aged and elderly people who have symptoms of osteoarthritis in five or more joints. All of the studies demonstrated a significant reduction in pain and stiffness. They also concluded that approximately 1000 mg of curcumin a day gave a reduction in symptoms equivalent to over-the-counter analgesics. This is important because turmeric extracts and curcumin do not have the same gastrointestinal and heart-related side effects (bleeding, high blood pressure and increased risk of heart attack) associated with commonly used pain medications. The side effects seem to be increased in the elderly -- the very people most affected by osteoarthritis.

Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor
Proceedings, November 2017
Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study showed that curcumin suppresses tumor progression, and alleviates the lipid peroxidation and improves antioxidant status in the tissues of solid tumor-bearing mice.

Turmeric's Anti-Inflammatory Properties
Science Trends, November 2017
It has been suggested that the compound curcumin helps the immune system destroy amyloid plaque, reducing the production of inflammatory cytokines. In doing so, brain function deterioration is reduced, slowing down the development of Alzheimer's disease. Epidemiological studies have looked at the neuroprotective effect of curcumin and have demonstrated that regular consumption has reduced other cognitive deficits in the elderly. Over the years curcumin has been a main focus for research regarding its strong anti-tumor effects. In fact, several preclinical trials have demonstrated curcumin to have both chemopreventive and anti-tumor effects against certain types of cancer. This naturally occurring polyphenolic compound recently has shown promise as a dietary therapy for pancreatic cancer. Of course, it shouldn't be thought of as a primary means for treating cancer, but it may reduce tumor promotion and minimize the spread of cancer. Turmeric has anti-inflammatory abilities containing more than two dozen compounds which may help relieve osteoarthritis pain. Again, it’s the compound curcumin that works as an anti-inflammatory agent. Clinical studies have found that curcumin provided protection to joint inflammation in individuals with osteoarthritis. Ulcerative colitis is a chronic, inflammatory bowel disease causing inflammation in the digestive tract. The disease tends to flare up and subside at random. Studies have shown people with ulcerative colitis who took curcumin had a significantly lower relapse rate than people who did not take curcumin. A meta-analysis showed curcumin had a high effect in reducing symptoms of depression, such as irritable mood, reduced interest in pleasurable activities, fatigue or feelings of worthlessness. The analysis suggests that curcumin could possibly have a role in treating the symptoms of major depression.

Curcumin suppresses Notch‑1 signaling: Improvements in fatty liver and insulin resistance in rats
Molecular Medicine Report, November 2017
Curcumin is a well‑known phenolic substance and has many pharmacological effects associated with metabolism. Curcumin administration led to a downregulation in the expression of lipogenic genes, including sterol regulatory element‑binding protein, fatty acid synthase and acetyl‑CoA carboxylase (P<0.05). The expression of inflammation‑associated genes, including nuclear factor‑κB, tumor necrosis factor‑α and prostaglandin‑endoperoxide synthase 2 were also suppressed. The results of the present study suggest that the hepatic Notch‑1 pathway can be suppressed via curcumin treatment, which may ameliorate fatty liver and insulin resistance in rats subjected to a high fat diet.

Foods for brain memory and function
The Medium, November 2017
According to Uma Naidoo, turmeric is an ingredient found in curry that appears to be responsible for de-plaguing the brain. Naidoo also explains that turmeric, also referred to as "Indian gold," has properties that benefit the brain, making you almost as bright as its own fiery complexion. The ingredient responsible for this powerful herb's effects on the brain is known as curcumin. Naidoo says, “Curcumin has been found to possess neuroprotective properties, and may help shield the brain against Alzheimer’s disease (AD) by binding to and eliminating toxic beta-amyloid plaques, which are a hallmark of AD."

Anti-neuroinflammatory effect of curcumin
International Journal of Molecular Medicine, November 2017
Curcumin is the main curcuminoid present in Curcuma longa and it has been previously reported to exhibit a wide range of pharmacological activities. Curcumin suppressed the secretion of inflammatory mediators through an increase in the expression of HO-1. Curcumin induced HO-1 transcription and translation through the Nrf2/antioxidant response element signaling pathway. Inhibitory experiments revealed that HO-1 was required for the anti-inflammatory effects of curcumin. Further mechanistic studies demonstrated that curcumin inhibited neuroinflammation by suppressing NF-κB and MAPK signaling pathways in Pam3CSK4-activated microglial cells. The results of the present study suggest that curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders.

Terrific Turmeric
Steinbach Online, November 2017
Due to recent research, curcumin has been nicknamed the "master off-switch for inflammation." It has been shown to help relieve pain and inflammation by modulating the inflammatory pathways that affect heart, joints, liver, gastrointestinal tract, brain, cellular health and the immune system! This makes curcumin useful for relieving the pain in osteoarthritis, rheumatoid arthritis and bursitis as well as in digestive conditions such as ulcerative colitis, Crohn's disease, celiac disease, gastritis and gastric ulcers. Curcumin has the ability to block more than 30 different inflammation pathways! Curcumin also protects against inflammatory calcium loss from our bones and has been shown to slow prostate cell proliferation in addition to supporting healthy cholesterol and blood pressure levels. Curcumin has liver-protective effects and is a powerful liver detoxifier. It helps to prevent the build-up of toxins, enhance glutathione levels, supports bile production and solubility as well as improve digestive function. Curcumin may help reverse certain forms of liver cirrhosis to some degree, and is thought to be especially helpful for people who regularly drink alcohol or use common painkillers, both of which damage cause liver damage. Studies suggest that curcumin can also reduce the severity of liver injury induced by iron overdose, cholestasis and carbon tetrachloride intoxication. In addition to supporting the liver processes, managing inflammation is also vital in aiding detoxification. Inflammation control is needed because the detoxification process involves the release of toxic metabolites from our cells and tissues in order to expel them from the body. On the way to being eliminated, these toxins can trigger inflammatory reactions and cause tissue damage. 
Curcumin, was originally researched for Alzheimer's disease because studies found there is a much lower incidence and prevalence of Alzheimer's in India than in North America. The association between curry consumption and cognitive level in certain populations were researched and it was found that those who ate curry foods performed better on a standard test than those who never or rarely ate curry! Alzheimer's disease degrades the nerve cells in the brain through inflammation in glial cells, the formation of beta-amyloid plaques, metal toxicity, and oxidative damage. Curcumin acts as a powerful anti-inflammatory and antioxidant in the brain. It can also break down plaques and has the potential to guard against their development, plus it supports healthy neurotransmitter function, improving memory and helping to prevent cognitive decline. 


Curcumin alleviates liver oxidative stress in type 1 diabetic rats
Molecular Medicine Reports, November 2017
The aim of the present study was to determine the effects of curcumin on antioxidants using a rat model of type 1 diabetes. The results provide evidence that oxidative stress in the STZ‑induced diabetic rat model may be attenuated by curcumin via the activation of the Keap1‑Nrf2‑ARE signaling pathway, as evidenced by a decrease in the blood glucose concentration and an increase in the transcription of several antioxidant genes.

Natural ingredients to help manage aches and pains
Body and Soul, November 2017
Turmeric is best known as a powdered spice used to give foods flavour and colour – think curries. It contains a natural chemical compound called curcumin that scientists have found to have anti-inflammatory and antioxidant properties. Research suggests turmeric and its components can potentially alleviate arthritis inflammation and pain. With curcumin accounting for only 3-5% of turmeric, you’re unlikely to get enough from diet alone, so consider a supplement to help boost levels.

Protective Effect of Curcumin Against Oxidative Stress-Induced Injury in Rats with Parkinson's Disease
Cellular Physiology and Biochemistry, November 2017
Background/Aims: The study aimed to investigate the protective effect of curcumin against oxidative stress-induced injury of Parkinson’s disease (PD) through the Wnt/β-catenin signaling pathway in rats. This study suggests that curcumin could protect against oxidative stress-induced injury in PD rats via the Wnt/β-catenin signaling pathway.

Keep breast cancer at bay
Telangana Today, November 2017
The spice that gives curry its beautiful yellow colour contains a chemical called curcumin. The studies have shown that curcumin supplements could play a role in helping fight breast cancer tumours.

Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats
Nutrients, November 2017
Curcumin has been proven to have a weight-loss effect in a menopausal rat model induced by ovariectomy. In conclusion, estrogen deficiency induced by ovariectomy caused changes in the distribution and structure of intestinal microflora in rats, and curcumin could partially reverse changes in the diversity of gut microbiota.

Reduce Inflammation with an Ancient Wonder Herb
Huffington Post, November 2017
Curmeric is a spice and a part of the ginger family that has been used for thousands of years. It's rich in a powerful natural phenol called curcumin. This wonder herb has been shown to be effective in treating low moods, either alone or in combination with an antidepressant. Curcumin contains powerful phytochemicals that reverse inflammation, and chronic inflammation has been shown to contribute to the development of a wide variety of disorders, depression being one that may be closely linked. A 2014 randomized control study compared three groups of 20 participants each. The three groups were given curcumin alone, Prozac® + 1g of oil based curcumin, or Prozac alone for a six-week period. They then had their low moods measured on a common scale. Surprisingly, the group on curcumin alone did just as well as those on Prozac alone. While there was not a major statistical significance among any of the three groups, the group on the combination scored best. The researchers found no safety concerns with the daily curcumin usage and concluded "This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD [major depressive disorder] without concurrent suicidal ideation or other psychotic disorders.”

Curcumin modulates covalent histone modification and TIMP1 gene activation to protect against vascular injury in a hypertension rat model
Experimental and Therapeutic Medicine, November 2017
Hypertension is a leading risk factor for morbidity and mortality. Previous studies have reported that curcumin has anti‑oxidation and anti‑aging effects and inhibits histone deacetylase activity. In conclusion, curcumin could relieve extracellular matrix degradation and interstitial fibrosis induced by hypertension, and lower blood pressure. It could also serve a function in improving vascular structure through inhibiting the expression of HDAC1, thereby promoting TIMP1 transcription activation and suppressing the expression of MMP‑2 and TGFβ.

Turmeric Is a Top Culinary Medicine
Natural Products Insider, November 2017
Nutritionists, functional medicine GP's and physiotherapists commonly use curcumin for it's anti-inflammatory qualities. And it's no wonder considering six major scientific trials all found curcumin to possess a potent anti-inflammatory action, which is completely non-toxic in nature.  A study evaluating several pharmaceutical anti-inflammatory drugs, found that aspirin and ibuprofen are the least potent, while curcumin is among the most potent anti-inflammatory and anti-proliferative agents available.. Arthritis is a debilitating inflammatory disorder. Thankfully curcumin has been found to help. A recent study out of Japan evaluated its relationship with the inflammatory cytokine known to be involved in in the rheumatoid arthritis process. Scientists discovered that curcumin "significantly reduced" these inflammatory markers. In fact its anti-inflammatory qualities are so strong a 2007 study compared curcumin and cortisone and found they were equal in potency! Most pharmaceutical anti-inflammatory drugs are contraindicated to use over the long-term, but turmeric is not only safe but beneficial for your overall well-being. Curcumin has been shown to equal in effectiveness to the drug metformin in the management of diabetes, but without negative side effects. (5) In the study curcumin was shown to lower blood glucose levels and reverse insulin resistance by suppressing glucose production in the liver. Another study found curcumin improved metabolic function and reduced the risk of plaque buildup in the arteries of type-2 diabetes patients. (6) Curcumin also acts as an anti-diabetic and antioxidant in patients with type-1 diabetes. With anti depressants prescriptions on an all time high, there has been a flood or recent trials attempting to get to the cause of depression. The core issue has finally been identified as inflammation. And curcumin has been found to be comparable to prescription antidepressant drugs.. In 2014 a randomized control trial took 60 volunteers diagnosed with major depressive disorder (MDD) and compared the effect of curcumin to fluoxetine (Prozac). (9) Researchers discovered that the principal curcuminoid in turmeric is not only as effective as Prozac in managing depression, but it doesn't carry with it all the dangerous side effects as anti-depressive drugs do. According to the paper, "This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD.”

Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors
Nutrition Journal, November 2017
Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs.

Curcumin Shrinks Aggressive Mesothelioma Tumors in New Study
Surviving Mesothelioma, November 2017
The latest study of cucumin in malignant mesothelioma treatment was conducted by French scientists at several different research centers. The team used cells taken from rats that had been induced to develop one of the deadliest and most aggressive subtypes of asbestos cancer called sarcomatoid mesothelioma. The rats began to develop sarcomatoid mesothelioma tumors in their abdomens within weeks of being injected with asbestos. The French scientists tested curcumin on cells from these tumors to determine the ideal killing dose. The team then used the sarcomatoid mesothelioma rats to test the treatment in vivo, in living animals. Compared with an epigenetic drug called SAHA, curcumin injected directly into the peritoneal cavities of sick rats was more effective and started to destroy their tumors in less two weeks. "The treatment of tumor-bearing rats with 1.5 mg/kg curcumin on days 7, 9, 11 and 14 after tumor challenge dramatically reduced the mean total tumor mass at day 16," reports Dr. Daniel L. Pouliquen, lead author on the report in Oncotarget. Earlier this year, scientists in the Department of Experimental Medicine at the University of Rome conducted a similar experiment and that found that intraperitoneal curcumin extended survival in mice with mesothelioma. In 2015, mesothelioma researchers with Flinders University in Australia determined that curcumin had the ability to keep mesothelioma tumors from giving rise to their own new blood vessels. That study suggested that curcumin could become a supplemental treatment for certain mesothelioma patients.

Curcumin is able to inhibit breast cancer cells
Oncology Letters, October 2017
The present study investigated the inhibitory effect of curcumin on human breast cancer MCF‑7 cells and investigated the potential underlying molecular mechanisms. MCF‑7 cells were cultured with curcumin at different concentrations and time points.  The proliferation of MCF‑7 cells in the group treated with curcumin was markedly decreased compared with the control, with the greatest inhibitory effect at a concentration of 20 µM. The expression of Bax mRNA was increased and Bcl‑2 mRNA expression was decreased compared with the control. Additionally, protein expression of NF‑κB and IκB was increased. The data indicate that curcumin is able to inhibit breast cancer cell proliferation, possibly by regulating the NF‑κB signaling pathway.

The Remarkable Anti-Cancer Activities of Curcumin
Experiment.com October 2017
Curcumin, a  diferuloylmethane, is a phytochemical derived from the rhizome of Curcuma longa, a member of the ginger family. It has been  used orally and safely as a spice and for medicinal purposes for many thousands of years in southern Asia and India. There are
 numerous published articles on laboratory, animal, and human studies examining its  effect as an anti-proliferative and anti-inflammatory on a wide variety of diseases.     It enhances induction of tumor antigen-specific, PD-1-positive,,    Cytotoxic T Lymphocytes [the Death Receptor] (1,2);,,    It arrests cancer, cells in various phases of the cell cycle, and induces apoptosis primarily through a,     mitochondrial pathway involving,, caspase-8-dependent BID cleavage (3);,,    It has been shown,     to inhibit constitutive NF-kB activation, induce G1/S arrest,,, suppress proliferation, and induce apoptosis in mantle cell lymphoma (4);,,    It induces apoptosis in human melanoma cells  through a Fas Receptor/Caspase-8 pathway,     independent of p53 (5);,,    It suppresses the proliferation of human vascular endothelial cells,,    in vitro and inhibits the Fibroblast Growth Factor-2-induced angiogenic,,    response in-vivo (6);,,    It induces apoptosis in the human acute myelogenous leukemia cell, line HL-60, believed to,     occur through the mitochondrial pathway involving caspase-8, BID cleavage,,     cytochrome C release, and caspase-3 activation (7);,,    It downregulates action of NF-kB and the antiapoptotic genes,,    regulated by NF-kB,,     a critical role in inhibiting cancer cell survival and proliferation in pancreatic cancer (8);,,    It suppresses expression of NF-kB, Bcl-2 and Bcl-XL in multiple,,    myeloma cell lines (9);,,    It potentiates the antitumor activity of gemcitabine in an in-vivo,, pancreatic cancer model through,     suppression of proliferation, angiogenesis, and inhibition of NF-kB -regulated,     gene products (10);,,    It induces gemcitabine sensitivity in pancreatic cancer cells through modulation of miR-200 and miR-21,     expression (11);,,    It inhibits tumor growth and angiogenesis in an orthotopic mouse model of,,    human pancreatic cancer (12);,,,    A liposomal-encased,     formulation of curcumin was studied in pancreatic cancer cell lines in vitro and in vivo, by, intravenous infusion, in athymic mice at the M.D. Anderson Cancer Center in,     Houston, Texas. Liposomal Curcumin was shown to down-regulate the NF-kB,     machinery, suppress tumor growth, and induce apoptosis in vitro, and demonstrated a reduction in, tumor burden and angiogenesis in vivo (13);,,    It inhibits growth and survival of human head and neck squamous carcinoma cells with modulation of of,     NF-kB signalling (14).

A Powerful And Cheap Supplement That You Aren't Using Enough
MensXP.com October 2017
The effects of curcumin are very similar to any synthetic anti-inflammatory drug. While synthetic drugs have side effects and may only be prescribed when needed, curcumin on the other hand, is a natural substance without side effects. Inflammation is an essential physiological function. Without our body's inflammation mechanism we would have no protection against pathogens. Although, short term (acute) inflammation works in our favor, but prolonged (chronic) inflammation which is a result of modern day stressful lifestyle is a key contributor to many western diseases. This includes heart disease, cancer, metabolic syndrome, Alzheimer's and much other health detrimental conditions. Including curcumin in the diet ensures the prevention of chronic inflammation. This is one benefit that our grandmother knew well before science confirmed it. This is the reason why you got a glass of hot milk mixed with turmeric every time you got injured. Curcumin is proven to relieve pain significantly at higher doses of 400-500mg. The pain relief benefits were found in post-operative patients and people suffering from arthritis and osteoporosis. This is comparable to 2g acetaminophen in potency. (a powerful painkiller).

Turmeric is a potential aid against precancerous cells
The Plaid Zebra, October 2017
Curcumin is one of the most powerful non-pharmaceutical anti-inflammatory compounds out there. It may provide the greatest benefits for stomach, breast, skin, bowel, brain, ovarian, colon, and prostate cancers. In fact, The American Cancer Society says that turmeric can be a potential treatment. It works by protecting the body from free radicals. Studies have also shown that curcumin also interrupts the progression, spread, and growth of cancerous cells. It also helps with the inflammation that is associated with the progression of cancer. The American Cancer Society mentions a study in which curcumin kills cancer cells in isolation, as noted in laboratory dishes.,,Curcumin inhibits COX-2, the enzyme that leads to negative inflammation that eventually leads to cancer. It also takes away the oxygen that fuels cancer cells. Additionally, it kills large cell B-cell lymphoma cells, and prevents the rebirth of cancer stem cells. Turmeric and curcumin have anti-carcinogenic agents. Carcinogens are greatly impactful to the development of cancerous cells. It mediates anti-carcinogenic action by raising levels of antioxidant enzymes. Curcumin and its derivatives are associated with anti-tumour activity.

Curcumin and Pancreatic Cancer Treatments
HealthProfessionalRadio.com October 2017
Ajay Goel, PhD., is Director of Translational Genomics and Oncology, and the Director of the Center for Gastrointestinal Research at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, TX. He is currently researching the prevention of gastrointestinal cancers using integrative and alternative approaches, including botanical products. Two of the primary botanicals he is investigating are curcumin (from turmeric) and boswellia.  Dr. Goel is a member of the American Association for Cancer Research and the American Gastroenterology Association and is on the international editorial boards of World Journal of Gastroenterology and World Journal of Gastrointestinal Oncology. Segment overview: Dr. Ajay Goel, PhD, senior author on a recent study published in the Oxford University Press’ journal “Carcinogenesis” that shows clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in pancreatic cancer patients.

Neuroprotective effects of curcumin
Molecular Medicine Reports, October 2017
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. The results of the present study suggest that pretreatment with curcumin can prevent the development of LIDD in rats. It was revealed that treatment with curcumin significantly reduced interleukin (IL)‑1β and IL‑6, iNOS, COX‑2 and MMP‑9 levels in rats with LIDD. In addition, treatment with curcumin reduced the mRNA expression levels of TGF‑β1 and TGF‑β2, whereas it increased the mRNA expression levels of BDNF in rats with LIDD. In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF.

A compound in turmeric could make cancer cells more sensitive to radiation
 Scroll, September 2017
Pre-treatment with curcumin – a safe herbal compound derived from turmeric – makes cancer stem cells sensitive to radiation therapy. It has found that combined effect of curcumin and exposure to radiation was markedly more effective in lowering AP-1 levels thereby rendering cells unviable for growth and replication. When treated with radiation alone, there was delayed but increased rate of proliferation and tumor formation. The mechanism of curcumin-induced inhibition lends credibility to AP-1 as a drug target and therapeutic utility of curcumin for radio-sensitisation of cervical cancer stem cells for better treatment outcomes.

Natural ways to support a healthy liver
News-Medical.net September 2017
Turmeric is a bright orange spice which has been long used in Indian cuisine and Ayurvedic medicine. Turmeric is reported to have the ability to protect the liver from damage. Animal studies have shown that mice fed curcumin, one of the active ingredients in Turmeric, suffered less liver damage over time compared with those on a normal diet. Curcumin has even been found to have a beneficial effect in the treatment of liver disorders
.

Investigating the effect an over-the-counter anti-inflammatory supplement called Curcumin has on the onset of Alzheimer’s.
AustralianAgeingAgenda.com September 2017
The preliminary findings suggested a longer period of time taking the supplement was required and the study has been extended for two years, Dr Goozee said. “We believe having people on the long-term Curcumin may have some benefit in being able to slow their accumulation or reduce what’s already there.”

Curcumin inhibits endoplasmic reticulum stress
Experimental and Therapeutic Medicine, September 2017
The aim of the present study was to observe the dynamic changes of the growth arrest and DNA damage‑inducible 153 (GADD153) gene and caspase‑12 in the brain tissue of rats with cerebral ischemia‑reperfusion injury (CIRI) and the impact of curcumin pretreatment. A total of 60 rats were randomly divided into the normal group (N), the sham operation group (S), the dimethyl sulfoxide control group (D) and the curcumin treatment group (C). For group D and C, 12 (T1), 24 (T2) and 72 h (T3) of reperfusion were performed after 2 h ischemia. The expression levels of GADD153 and caspase‑12 in the brain tissue were detected and compared among the groups by immunohistochemistry, immunofluorescence double staining and western blotting. The expression levels of GADD153 and caspase‑12 were increased at T1compared with groups N and S, and the expression of caspase‑12 peaked at T2 in group D, while GADD153 was increased until T3 in group D. Compared with group D, the expression levels of GADD153 and caspase‑12 in group C at T2 and T3 were significantly decreased (P<0.05). Endoplasmic reticulum stress is involved in the pathological process of CIRI. Curcumin may decrease the expression levels of the above two factors, thus exhibiting protective effects against CIRI in rats.

Can curry spice really help banish your aches and pains? Yes - and women may benefit from nature's painkiller the most
DailyMail, September 2017
Curcumin is a strong anti-inflammatory agent and chronic inflammation is the precursor of the vast majority of cancers.,,Turmeric helps cells regulate their growth and survival, including the recycling of worn out cells, and the self-destruction of abnormal cells which have the potential to form tumours. Turmeric is traditionally used to support weight loss. Curcumin boosts the metabolic rate of ‘good’ brown fat cells so they burn more fat as a fuel – this is one reason why you may find yourself sweating after eating a spicy curry.,,The latest news is that curcumin also helps to regulate the production of hormones linked with obesity, such as resistin (which links obesity with insulin resistance and type 2 diabetes), leptin (the satiety hormone) and adiponectin (a hormone involved in fat breakdown). Curcumin has beneficial effects against skin inflammation by quenching free radicals, reducing inflammation.,,In psoriasis, this helps to slow the over-production of cells that lead to plaque formation.

Curcumin Alleviates the Functional Gastrointestinal Disorders of Mice In Vivo
Journal of Medicinal Food, September 2017
Curcumin is a natural polyphenol extracted from the turmeric rhizome, which has a wide range of biological activities, but until now the effects of curcumin on the gastrointestinal peristalsis have not been fully understood. In vivo study, we observed the effects of curcumin on gastric emptying and intestinal propulsion rates of mice in normal state and in delayed state by atropine (ATR) or nitric oxide precursor L-arginine (L-Arg). An in vitro study explored the direct effects of curcumin on the intestinal contractility, but were studied through measuring spontaneous contraction of isolated jejunum of mice. Our results showed that intragastric administration of curcumin (200 mg/kg/day) for 10-20 days significantly improved gastric emptying and intestinal propulsion rates of mice delayed by ATR. Moreover, intragastric administration of curcumin (200 mg/kg/day) for 15 days also significantly improved mice gastric emptying and intestinal propulsion rates delayed by L-Arg.

Potential Role of Curcumin Against Biofilm-Producing Organisms on the Skin: A Review
Phytotherapy Research, September 2017
Turmeric root (Curcuma longa) is predominantly used as a spice, but has also long been known to possess antimicrobial, analgesic, antiinflammatory, and anticancer properties. One predominant group of active compounds in turmeric are curcuminoids, namely bright yellow-pigmented curcumin. While modern science has yet to fully investigate the therapeutic claims of turmeric and its derivatives, results have proven promising in decreasing pain and inflammation in arthritis, improving insulin sensitivity in diabetes, and even curing a variety of infections.  Curcumin has demonstrated bactericidal efficacy against a variety of infections when administered with antibiotics in several clinical studies, with consistent antimicrobial activity demonstrated in vitro, as well as in urinary tract infections, gingival infections, and chronic wound infections. Hypothesized mechanisms of action include curcumin's ability to perturb bacterial membranes, disturb protofillament assembly, and even impair bacterial virulence factors.

Shield against Alzheimer's dementia
Times of India, September 2017
"Turmeric contains a curcumin, the bright yellow chemical that gives turmeric its colour, which acts like a protective shield towards the problem," he added. There is a great body of evidence to prove the positive impact of turmeric on prevention and treatment of AD. As per Antioxidants-2016 - an academic publication of Multidisciplinary Digital Publishing Institute (open-access publisher), termed turmeric as an alternative therapy for AD. Similarly, London based Alzheimer's society noted that curcumin in turmeric can break down Amyloid-beta plaques (amino acids that play a key role in development of dementia).

Health Benefits of Turmeric: 5 Proven Benefits of Turmeric
India.com September 2017
Curcumin present in turmeric improves the brain function by boosting Brain-Derives Neurotrophic Factor (BDNF), a growth hormone present in the brain. It drives the process of formation of new neuron connections. Neurons develop new connections in a specific area of the brain. Turmeric also helps lower the risk of brain diseases by boosting BDNF in the brain. The increased levels of BDNF delays or reverses several age-related brain damages and brain diseases. Turmeric contains curcumin, which is beneficial for your heart. Curcumin improves your heart health by improving the function of the blood vessel lining called endothelium. According to some studies, curcumin improves the endothelium function. Studies showed that it is as effective as the drug Atorvastatin or works as well as exercises. Curcumin also reduces oxidation and inflammation, which in turn improve the heart health.

Long-term stabilisation of myeloma with curcumin
British Medical Journal, August 2017
Here, we describe a myeloma patient who started a daily dietary supplement of curcumin when approaching her third relapse. In the absence of further antimyeloma treatment, the patient plateaued and has remained stable for the last 5 years with good quality of life. Curcumin is a polyphenol derived from the perennial herb Curcuma longa (turmeric) and has, for centuries, been used as a traditional Indian medicine. Several reports published over the two decades have claimed various health benefits of curcumin and this has led to its increasing popularity as a dietary supplement to prevent or treat a number of different diseases. The biological activity of curcumin is indeed remarkable. It is a highly pleiotropic molecule which possesses natural antioxidant, anti-inflammatory, antiseptic and analgesic properties. More recently, it has demonstrated antiproliferative effects in a wide variety of tumour cells including myeloma cells and exerts its antiproliferative effects through multiple cellular targets that regulate cell growth and survival.

New science confirms curcumin every day reverses cancer
Natural News, August 2017
A report in the British Medical Journal illustrates how a woman has beaten blood cancer with the help of turmeric. In 2007, 67-year-old Dieneke Ferguson was diagnosed with myeloma and she progressed to stage three within 15 months. Three failed rounds of chemotherapy and four failed stem cell transplants later, doctors told her she had very little hope. Four years after her initial diagnosis, she took matters into her own hands and started taking a daily dose of curcumin, the key component of turmeric. She took eight grams every evening on an empty stomach.
Since then, her cancer has stabilized and her blood counts have returned to normal. The BMJ report says that Ferguson’s results suggest that turmeric could be used to help myeloma patients in the future, adding: “The fact that our patient, who had advanced stage disease and was effectively salvaged while exclusively on curcumin, suggests a potential antimyeloma effect of curcumin.” No other possible explanation for her recovery. The report’s co-author, Jamie Cavenagh, said that there is no other possible explanation for her remarkable recovery beyond the curcumin. She continues to take the tablets to this day. The scientists are recommending further evaluation in clinical trials to pursue the possibility of using it as an official treatment. This could prove difficult, however, because doctors cannot prescribe it until it has been tested in wide-scale trials that cost millions. Natural compounds cannot be patented, so finding an investor would be extremely difficult.

Turmeric helped cancer patient, 57, beat myeloma after five years of treatment
The Sun, August 2017
Dieneke Ferguson took eight grams of curcumin each night for five years and her cancer has remained stable. Curcumin is a polyphenol derived from the perennial herb turmeric and has been used as a traditional Indian medicine for centuries.  Curcumin is a natural antioxidant, anti-inflammatory, antiseptic and has analgesic properties, according to the BMJ report.  More recently, it has demonstrated an ability to slow or inhibit cell growth in a wide variety of tumour cells, including myeloma.  It has also been found to help alleviate a range of other health problems.

Turmeric may help fight the most common type of cancer found in infants
Mic.com August 2017
A popular spice frequently used in curries may be combatting the most common cancer cells afflicting infants, according to a recent study. Turmeric, a vibrant yellow spice seen in dishes such as roasted vegetables and soups, contains a chemical called curcumin. Recent research suggests that curcumin helps destroy neuroblastoma tumor cells, which often start in the embryo or fetus. These particular tumor cells can become resistant to drug treatments, scientists say, meaning that a new treatment plan involving turmeric could make all the difference. For children, neuroblastoma can be a severe health obstacle. About 700 new cases appear each year in the U.S., mostly diagnosed in kids younger than age 5. This type of cancer can delay development and cause hearing loss or other disabilities. That aside, the medical treatment itself can be difficult: Kids can suffer serious side effects or damage from traditional methods such as chemotherapy, for example. “This research demonstrates a novel method of treating this tumor without the toxicity of aggressive therapy that can also have late effects on the patient’s health,” Tamarah J. Westmoreland, a lead researcher on the study, said in a release.

Chemical from turmeric helps treat cancer in children: Study
TheHindu.com August 2017
Scientists in the U.S. have found yet another use for curcumin, the bioactive component of turmeric that is widely used in Indian cuisine, this time to treat cancer in children. Researchers at Nemours Children’s Hospital and the University of Central Florida (UCF) have found that nanoparticles loaded with curcumin can target and destroy neuroblastoma tumour cells. Children aged five or less are most commonly affected. In their study, the researchers attached curcumin to cerium oxide nanoparticles and tested the nano-curcumin formulation in cell lines of a high-risk form of neuroblastoma. “This formulation induced substantial cell death in neuroblastoma cells while producing no or only minor toxicity in healthy cells,” says the report published in Nanoscale . Curcumin has been shown to have substantial anti-cancer ability, but its low solubility and poor stability have restricted its use in therapeutic applications. The study demonstrates a treatment method “without the toxicity of agressive therapy” and shows that nanoparticles can be “an effective delivery vehicle” for cancer drugs, said a statement from UCF.

Starving Prostate Cancer With What You Eat for Dinner
University of Texas, August 2017
Curcumin combined with other nutrients has anti-cancer properties. The researchers first tested 142 natural compounds on mouse and human cell lines to see which inhibited prostate cancer cell growth when administered alone or in combination with another nutrient. The most promising active ingredients were then tested on model animals: ursolic acid, a waxy natural chemical found in apple peels and rosemary; curcumin, the bright yellow plant compound in turmeric; and resveratrol, a natural compound common to red grapes or berries. “These nutrients have potential anti-cancer properties and are readily available,” says Tiziani. “We only need to increase concentration beyond levels found in a healthy diet for an effect on prostate cancer cells.” The new research paper also demonstrates how the plant-based chemicals work together. Combining ursolic acid with either curcumin or resveratrol prevents cancer cells from gobbling something that they need to grow, glutamine. This is a neat solution: blocking the uptake of a nutrient needed by prostate cancer cells with nutrients that are commonly in the human diet.

Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation
Molecular Medicine Reports, August 2017
curcumin exerts a marked effect on aortic aneurysm development. In rat tissues, treatment with curcumin resulted in reduced aneurysm size and restored the wavy structure of the elastic lamellae. In addition, curcumin decreased neovascularization and the expression of VEGF. Immunohistochemical analysis indicated that curcumin significantly inhibited infiltration of cluster of differentiation (CD)3+ and CD68+ cells in TAA. Furthermore, curcumin treatment decreased the expression of vascular cell adhesion molecule‑1, intracellular adhesion molecule‑1, monocyte chemoattractant protein‑1 and tumor necrosis factor‑α. Collectively, the results demonstrated that angiogenesis and VEGF expression were increased in the aortic wall in TAA. Treatment with curcumin inhibited TAA development in rats, which was associated with suppression of VEGF expression. In addition, curcumin attenuated inflammatory cell infiltration and suppressed inflammatory factor expression in the periaortic tissue of TAA.

Underlying Mechanisms ID'd in Curcumin Resensitization of CA Cells
HealthDay News, August 2017
Curcumin can resensitize chemoresistant pancreatic ductal adenocarcinoma (PDAC) cells through inhibition of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis, according to a study published online July 17 in Carcinogenesis. The researchers reported the resensitization of chemoresistant PDAC cells by curcumin through inhibition of the PRC2-PVT1-c-Myc axis. Curcumin sensitized chemoresistant cancer cells inhibited expression of the PRC2 subunit enhancer of zeste homolog-2 and its related long non-coding RNA PVT1 using gemcitabine-resistant PDAC cell lines. Curcumin also prevented spheroid formation and down-regulated several genes driving self-renewal. In vitro findings were confirmed in a xenograft mouse model, with inhibition of gemcitabine-resistant tumor growth by curcumin. "Overall, this study establishes clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC," the authors write.

Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression
Carcinogenesis, August 2017
Accumulating evidence indicates that curcumin, a phenolic compound extracted from turmeric, can overcome de novo chemoresistance and re-sensitize tumors to various chemotherapeutic agents. Using gemcitabine-resistant PDAC cell lines, we found that curcumin sensitized chemoresistant cancer cells by inhibiting the expression of the PRC2 subunit EZH2 and its related lncRNA PVT1. Curcumin was also found to prevent the formation of spheroids, a hallmark of CSCs, and to down-regulate several self-renewal driving genes. In addition, we confirmed our in vitro findings in a xenograft mouse model where curcumin inhibited gemcitabine-resistant tumor growth. Overall, this study indicates clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC.

Kitchen spice helps woman beat cancer
israelnationalnews.com August 2017
Dieneke Ferguson, 67, battled myeloma for five years, thought she had lost, and then tried a key component of a common kitchen spice: curcumin. Now, five years later, her cancer cell count is negligible, the Daily Mail reported.  Her recovery was so remarkable it was featured in the British Medical Journal. However, the report emphasized that few - if any - of myeloma sufferers used curcumin on its own, without conventional treatments.  And co-author Jamie Cavenagh, who works at London’s Barts Hospital as a specialist in blood disease, said many of his patients take curcumin at some point, but it doesn't work for everyone.  "A lot of my patients take curcumin at different stages of their treatment. I don’t object to it," Cavenagh said. " Dieneke’s is the best response I have observed and it is clear-cut because we had stopped all other treatment. I have not seen such a convincing response before."  "When you review her chart, there’s no alternative explanation [for her recovery] other than we’re seeing a response to curcumin."  Myeloma is a type of blood cancer, and to treat it, Ferguson first tried three rounds of chemotherapy and four stem cell transplants.  Ferguson currently takes 8 grams of curcumin a day (equivalent to two teaspoons of powered curcumin), mostly to ensure the disease does not come back.

Cancer breakthrough: Trendy spice could be key to killing tumours
Express, August 2017
The curcumin chemical in turmeric has shown promise destroying neuroblastoma tumour cells.

Could a turmeric extract help to treat pancreatic cancer?
Medical News Today, August 2017
A common obstacle in the treatment of pancreatic cancer is drug resistance. However, new research has shown that curcumin - a compound that can be found in turmeric - can help to overcome the resistance to chemotherapy. Curcumin is the active compound found in plants such as turmeric, and more and more studies have been pointing to the therapeutic potential of the compound for various conditions, ranging from cancer to diabetes. Preclinical studies have suggested that the compound has various antioxidant, neuroprotective, anti-inflammatory, and anticarcinogenic properties. "By treating certain cells with small doses of curcumin, we were able to reverse the pathways that lead to chemoresistance," says Dr. Goel.   "This is an important breakthrough that could lead to better prognosis and longer lives for patients with chemoresistant pancreatic cancer." Previous studies have shown that curcumin has preventative benefits, but to the authors' knowledge, this is the first study that shows the beneficial effect of the plant extract in combination with chemotherapy and its advantages in overcoming drug resistance.

Baylor Scott & White Research Institute Shows Curcumin Protects Against Chemoresistant Pancreatic Cancer
Healthcare Magazine, August 2017
Baylor Scott & White Research Institute scientists found curcumin, a plant-based medicinal compound, can help overcome chemotherapy resistance in pancreatic ductal adenocarcinoma, the country’s fourth leading cause of cancer-related deaths.  According to researchers, resistance to chemotherapeutic drugs is a major challenge for PDAC patients. Initially, patients may respond to chemotherapy but, as cancer stem cells form, patients’ bodies may become immune to chemotherapy drugs. The Baylor Scott & White study stated curcumin can act as an adjunct to chemotherapy to battle this.  “By treating certain cells with small doses of curcumin, we were able to reverse the pathways that lead to chemoresistance,” Dr. Ajay Goel, director of gastrointestinal research and translational genomics and oncology at Baylor Scott & White Research Institute, said in a statement. “This is an important breakthrough that could lead to better prognosis and longer lives for patients with chemoresistant pancreatic cancer.”  Goel said his team had identified two key players in regulating drug resistance. Researchers found that when pancreatic cancer cells were treated with curcumin, the natural compound inhibited pathways associated with chemotherapy drug resistance—increasing reception to first-line drug therapy. Researchers also found curcumin can prevent the formation of spheroids, in turn reducing tumor growth and recurrence.  Currently, Goel and his research team are continuing to explore the benefits of curcumin. There are clinical trials underway studying the role of curcumin in cervical, breast, and colorectal cancers.

Curcumin Compound in Turmeric May be Used to Help Fight Cancer in Children: Scientists
NDTV.com, August 2017
A team of scientists from the United States of America have found that a bioactive compound in turmeric known as curcumin can also cure cancer in children. Neuroblastoma is one of the most common cancers in children below the age of five years. The cancer starts in early nerve cells and commonly forms in the tissue of the adrenal glands, near the kidneys. It is also associated with developmental delays, hearing loss and other disabilities.

Turmeric can be used to fight cancer in children, find US scientists
Economic Times, August 2017
Researchers at Nemours Children's Hospital and the University of Central Florida (UCF) have recently found that the nanoparticles loaded with curcumin can offer a novel treatment to target and destroy neuroblastoma tumor cells.

Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation.
PubMed, August 2017
Studies on proliferation, antioxidant activity and scratch wound healing carried out in human keratinocyte cells revealed that HA-conjugated curcumin treatment enhanced cell proliferation, decreased oxidative damage induced by H2O2 and also improved migration of cells in scratch wounds as compared to treatment with native curcumin. HA conjugated curcumin exhibited bactericidal activity in dark and phototoxicity when irradiated with blue light against antibiotic resistant bacteria. Furthermore, wound healing efficacy studied in diabetic mice demonstrated that topical application of the conjugate on wounds led to better healing as compared to treatment with HA-free curcumin and HA alone. These results suggest that HA conjugation is a promising formulation of curcumin for enhancing its healing efficacy.

Researchers Show Curcumin Protects Against Chemoresistant Pancreatic Cancer
NewsWise.com August 2017
Curcumin is known for its powerful anti-inflammatory and antioxidant benefits, but a new study by researchers at Baylor Scott & White Research Institute reveals an additional benefit: its potential to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC), a common but aggressive form of cancer in the pancreas. The study, “Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression,” recently was published in Carcinogenesis, an integrative cancer research journal. Previous research demonstrated the advantages of taking curcumin preventatively, but this is the first study of its kind to demonstrate benefits of curcumin as an adjunct to chemotherapy. Resistance to chemotherapeutic drugs is a major challenge in caring for patients with PDAC, the fourth leading cause of cancer-related U.S. deaths. Patients may respond to chemotherapy initially, but as cancer stem cells form, the body can develop drug resistance. Now, researchers have developed an improved understanding of the molecular events underlying the development of pancreatic stem cells and the role that curcumin—the main component of turmeric—plays in overcoming resistance to vital chemotherapy drugs.

Curry spice helped woman, 67, to beat blood cancer
Metro, August 2017
Dieneke Ferguson, 67, thought she had exhausted all options available after undergoing three rounds of chemotherapy and four stem cell transplants as she battled myeloma. However, she then turned to a product called curcumin, which is an ingredient of the spice turmeric, and her recovery was so incredible it has been featured in the British Medical Journal. Although curcumin features in kitchen turmeric, it only makes up around 2%, so Dieneke takes the ingredient in tablet form so she can get 8g a day. After five years of taking the tablet, that she heard about on a cancer support group, her cancer cell count is negligible.

The Benefits Turmeric Has on Your Skin
The Weekly Challenger, August 2017
Scientific studies as recent as 2017 preach the anti-inflammatory and wound-healing properties of turmeric, due to the curcumin inside the plant. Other studies have found that turmeric can help reduce skin damage, including damage due to sun exposure, pollution, smoking, aging, and acne.

How curry spice helped a dying woman beat cancer: Sufferer, 67, turned to kitchen cupboard staple turmeric after five years of failed treatment
Mail Online, August 2017
How curry spice helped a dying woman beat cancer: Sufferer, 67, turned to kitchen cupboard staple turmeric after five years of failed treatment. Dieneke Ferguson was diagnosed with the blood cancer myeloma in 2007 and underwent three rounds of chemotherapy as well as four stem cell transplants. She tried Curcumin, a component of turmeric, and five years on, her cancer cell count is negligible, with her recovery featuring in the British Medical Journal.  Curcumin has been linked to a host of benefits, including for heart disease.

5 Foods That Help Fight Cancer
The Quint, August 2017
Curcumin (turmeric extract) works brilliantly with cancer patients and balances the side effects of chemo by boosting immunity. Its highly anti-microbial and anti-inflammatory and that helps because cancer is an inflammatory disease.

Synergistic Interplay between Curcumin and Polyphenol-Rich Foods in the Mediterranean Diet: Therapeutic Prospects for Neurofibromatosis 1 Patients
Nutrients, August 2017
After six months, patients adopting a traditional MedDiet enriched with 1200 mg curcumin per day presented a significant reduction in the number and volume of cutaneous neurofibromas; these results were confirmed in subsequent evaluations. Notably, in one patient, a large cranial plexiform neurofibroma exhibited a reduction in volume (28%) confirmed by Magnetic Resonance Imaging. We hypothesize that the combination of a polyphenol-rich Mediterranean diet and curcumin was responsible for the beneficial effect observed on NF1. This is, to the best of our knowledge, the first experience with curcumin supplementation in NF1 patients. Our report suggests that an integrated nutritional approach may effectively aid in the management of NF1.

The best immune system-boosting foods
Coach, August 2017
A component of turmeric called curcumin, which gives the spice its orange-yellow colour, has been shown to have a potent stimulatory effect on the immune system. A study carried out by American and Chinese researchers last year found the consumption of curcumin resulted in the body producing more white blood cells, which then removed a tuberculosis causing bacteria from infected cells.

Family Living Focus: Turmeric
Lancaster Farming, August 2017
Curcumin, the active substance in turmeric, is a powerful antioxidant. Antioxidants aid against cell damage.  Curcumin lowers the level of two enzymes in the body that cause inflammation.  Curcumin stops platelets from clumping together to form blood clots.  Curcumin has been found to reduce the symptoms of bloating and gas in people suffering with indigestion.

Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer
Journal of Cellular Biochemistry, August 2017
The effect of curcumin on inhibiting cancer has been recognized, but the mechanism remains elusive. This study tests a hypothesis that administration of curcumin down regulates Tregs in lung cancer (LC) patients. In this study, a group of LC patients was treated with curcumin. The peripheral Tregs and T helper (Th) 1 cells were analyzed by flow cytometry. The mechanism by which curcumin regulated the Tregs was observed by cell culture approaches. The results showed that the frequency of peripheral Treg was markedly higher in LC patients than that in healthy subjects, which was suppressed after treating with curcumin for 2 weeks. The peripheral Th1 cells were increased in LC patients after the curcumin therapy. The data of the in vitro experiments showed that curcumin converted the LC patient-isolated Tregs to Th1 cells via repressing the gene transcription of forkhead protein-3 and increasing the expression of interferon-γ. In conclusion, curcumin can convert LC patient-isolated Tregs to Th1 cells. The results suggest that curcumin may improve the antitumor immunity by regulating the tumor specific immune tolerance.

Compounds in Apples, Grapes and Other Plant Foods Stop Prostate Cancer in Mice, Study Shows
Prostate Cancer News, July 2017
Researchers tested 142 natural compounds in food for prostate-cancer-fighting properties. They discovered that combinations of ursolic acid, resveratrol and curcumin stopped the disease. Ursolic acid is found in apple peels and the herb rosemary, resveratrol in red grapes and berries, and curcumin in the spice turmeric.  The study, “Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism,” was published in the journal npj Precision Oncology.  To start with, the University of Texas researchers tested the compounds on prostate cancer cells in a lab. They evaluated the substances alone and in combinations.  When the team discovered that ursolic acid, resveratrol and curcumin might inhibit prostate cancer growth, they tested all possible combinations of the compounds in mice with prostate cancer. Some combinations prevented tumor growth in the animals, with no toxic effects.  Scientists already know that chemicals in apple peels, turmeric and green tea reduce inflammation, a risk factor for cancer because it damages normal cells.  The researchers also wanted to know how the compounds inhibited tumor growth. They studied metabolic pathways, or chemical transformations needed to nourish cancer cells.  They found that ursolic acid, combined with either resveratrol or curcumin, kept cancer cells from consuming glutamine, a compound the cells need to grow. Denying the cells glutamine starved them.

Natural Compounds in Ordinary Foods Beat Prostate Cancer
News Max, July 2017
They first tested 142 natural compounds on mouse and human cell lines to see which inhibited prostate cancer cell growth when administered alone or in combination with another nutrient. The most promising active ingredients were then tested on model animals: ursolic acid, a waxy natural chemical found in apple peels and rosemary; curcumin, the bright yellow plant compound in turmeric; and resveratrol, found in red grapes and berries.,,The found that when combined with either curcumin or resveratrol, ursolic acid prevented the uptake of glutamine, a nutrient necessary for cancer growth.,,"These nutrients have potential anti-cancer properties and are readily available," says Stafano Tiziani. Combinations of the nutrients, he says, "have a better effect on prostate cancer than existing drugs.,,"The beauty of this study is that we were able to inhibit tumor growth in mice without toxicity," Tiziani said.,,The study was published in Precision Oncology.

Pre-treatment with curcumin - a safe herbal compound derived from turmeric – makes cancer stem cells sensitive to radiation therapy.
Down To Earth, July 2017
The study builds upon earlier findings that pre-treatment with curcumin - a safe herbal compound derived from turmeric – makes cancer stem cells sensitive to radiation therapy. It has found that combined effect of curcumin and exposure to radiation was markedly more effective in lowering AP-1 levels thereby rendering cells unviable for growth and replication. When treated with radiation alone, there was delayed but increased rate of proliferation and tumor formation.  The mechanism of curcumin-induced inhibition lends credibility to AP-1 as a drug target and therapeutic utility of curcumin for radio-sensitization of cervical cancer stem cells for better treatment outcomes.

Natural Ways to Lower Your Cholesterol
FitCommerce.com July 2017
Turmeric, the spicy yellow ingredient found in Indian food, contains the active ingredient, curcumin. Recent research suggests that curcumin may reduce cholesterol by interfering with intestinal cholesterol uptake, increasing the conversion of cholesterol into bile acids, and increasing the excretion of bile acids. Curcumin has powerful antioxidant and anti-inflammatory properties and may help prevent the oxidation of LDL cholesterol to a more dangerous form that is more likely to end up in your arteries.

Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats
Experimental and Therapeutic Medicine, July 2017
The results showed that curcumin significantly decreased serum amylase, Cr and BUN levels, and alleviated pancreatic and renal histological changes in SAP rats. Furthermore, curcumin markedly decreased serum TNF‑α and IL‑6 levels and downregulated renal protein levels of JAK2/STAT3 pathway components. These results proved that curcumin ameliorates acute renal injury in a rat model of SAP. The molecular mechanism of its effect may be associated with the suppression of the JAK2/STAT3 pathway to reduce TNF‑α and IL‑6 levels in SAP‑induced acute renal injury. Therefore, the findings of the present study revealed the potential use of curcumin for the prevention and treatment of SAP and the associated renal injury.

Prostate Cancer Cells Can Be Treated With Natural Compounds Present In Apple, Red Grape & Turmeric
The Science Times, July 2017
The researchers performed the tests of the compounds individually and also in combination. They identified three key compounds that played effectively in halting the growth of the prostate cancer cells. The three effective compounds are curcumin, ursolic and resveratrol.  A bright yellow curcumin is a natural compound present in turmeric, and ursolic acid can be found in the apple peel. Another important natural compound resveratrol is present in berries and red grapes. The researchers combined the ursolic acid with either resveratrol or curcumin and tested it in the mice with induced prostate cancer. They noticed that the compounds stopped the necessary uptake of the important amino acid glutamine by the prostate cancer cells.  The uptake of this amino acid helped the prostate cancer cells to grow. Now the prevention of the glutamine's uptake forced the cells to starve. This starvation ultimately led to the death of the prostate cancer cells and simultaneously halted the growth of the tumor in the mice.  One important fact is natural compounds curcumin, resveratrol, and ursolic acid caused no toxic effects on mice. The researchers found that the concentrations of the natural compounds in the mice were higher than they are normally present and consumed through the diet. However, the findings of the study have indicated promising outcome to prevent and treat the prostate cancer cells.

Life-Changing Benefits Of Turmeric
Elite Daily, July 2017
 Studies show that, in India, diagnoses of Alzheimer's disease are pretty low, and it appears to be due to turmeric's major role in the Indian diet. Curcumin helps to improve working memory, as well as attention span and mood in elderly adults.  According to a 2014 study, 60 healthy adults showed significantly improved performance on attention and working memory tasks only one hour after receiving a single dose of 400 mg of curcumin, compared with those who received a placebo. Curcumin can kill damaged cells while still leaving other cells healthy and intact, unlike chemotherapy. According to GreenMedInfo, turmeric reduces post-bypass heart risk by 56 percent.  Not only that, but the effects it has on heart health are similar to the effects that aerobic exercise has on heart health, and it improves vascular function in post-menopausal women. Curcumin can possibly be just as effective as an antidepressant.Its work with depression is related to its anti-inflammatory properties because people with depression have greater inflammation and oxidative stress, which can affect all major organs in the body, including the brain, according to Psychiatry Advisor.

Apples and Curry May Starve Prostate Cancer Cells
Vital Updates, July 2017
The study authors discovered cancer-limiting effects with curcumin, which is found in the “wonder spice” turmeric, as well.  “These nutrients have potential anti-cancer properties and are readily available,” said corresponding author Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at University of Texas at Austin. One of the most important findings that the researchers uncovered was how chemical combinations could limit glutamine metabolism in cancer cells, which need the substance to survive. Specifically, the researchers found that combining ursolic acid with resveratrol or curcumen made the biggest impact.

Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells
PLoS One, July 2017
The mechanisms by which curcumin promoted cell death in these cells were associated with cell cycle arrest, increased reactive oxygen species, autophagy and the Unfolded Protein Response. Furthermore, the upregulation of ER stress was measured using key indicators of ER stress: Glucose-Regulated Protein 78, Inositol-Requiring Enzyme 1 alpha, Protein Disulfide isomerase and Calreticulin. Chronic ER stress induction was concomitant with the upregulation of pro-apoptotic markers (caspases 3,9,12) and Poly (ADP-ribose) polymerase. The downregulated proteins include anti-apoptotic and anti-tumor markers, supporting their curcumin-induced pro-apoptotic role in prostate cancer cells. Taken together, these data suggest that curcumin may serve as a promising anticancer agent by inducing a chronic ER stress mediated cell death and activation of cell cycle arrest, UPR, autophagy and oxidative stress responses.

Relieve Pain Naturally
The Alternative Daily, July 2017
Curcumin is now one of the most effective anti-inflammatory agents known to man, and you’ll see curcumin supplements on most health store shelves across the globe. Ancient civilizations came to refer turmeric, and hence it’s active ingredient curcumin, as an almost holy plant, in large part because of it’s amazing healing powers.  Curcumin works by regulating cytokines, proteins and enzymes that are linked to inflammation. This has lead many scientists to conclude that curcumin may be one of the most effective ways to treat chronic neurodegenerative, cardiovascular, metabolic and neoplastic diseases.

Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
Science Direct, July 2017
Curcuminoids supplementation can reduce serum levels of atherogenic lipid indices including non-HDL-C and Lp(a). Therefore, curcuminoids supplementation could contribute to a reduced risk of cardiovascular events in dyslipidemic patients with T2D.

Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's disease: protecting spatial learning and memory
Journal of Neurorestoratology, July 2017
Curcumin relieved spatial learning and memory deficits, hippocampus neuronal apoptosis, and reduced JNK-3 and p-JNK-3 levels (all P<0.05). In conclusion, curcumin may inhibit JNK-3 phosphorylation to protect against hippocampal neuron apoptosis after Aβ injection.

Topical Curcumin for Precancer Cervical Lesions
ClinicalTrials.gov July 2017
The purpose of this study is to see if curcumin can reverse a cervical precancerous state by looking at people who have the condition and intervening with a study drug or placebo (an inactive drug), prior to planned therapeutic loop electrosurgical excision procedure (LEEP) which is a treatment procedure for removing cervical cancer.

Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A549
Oncology Letters, July 2017
The anticancer effects of curcumin on A549 cells can be reduced using autophagy inhibitors. This suggests a possible cancer therapeutic application of curcumin through the activation of autophagy. These findings have improved the understanding of the mechanism underlying the anticancer property of curcumin.

Food Derived Compounds Block Prostate Cancer Growth
Specialty Pharmacy Times, July 2017
 The investigators identified ursolic acid, a natural chemical found in apple peels and rosemary; curcumin, a compound in turmeric; and resveratrol, a natural compound in red grapes or berries, as the most promising active ingredients and tested them on animal models.   “These nutrients have potential anti-cancer properties and are readily available,” Tiziani said. “We only need to increase concentration beyond levels found in a healthy diet for an effect on prostate cancer cells.”   The study also showed that combining ursolic acid with either curcumin or resveratrol can prevent cancer cells from accessing crucial nutrients needed to survive. In other words, through nutrients commonly found in the human diet, the compounds can block the uptake of glutamine, which prostate cancer cells need to grow.

Turmeric And Ginger Make My Top Local “Superfood”
Longevity, July 2017
There is literally no nutrient more effective than curcumin at promoting a healthy inflammatory response in your brain, heart and body. Multiple studies say that the spice naturally detoxes the body and supports, pain-free joints, balanced moods and strong immune systems. Curcumin even improves metabolic function and reduces the risk of plaque buildup in the arteries of type-2 diabetes patients. Lastly it acts as an anti-diabetic and antioxidant in patients with type-1 diabetes. FYI, studies even say that it’s just as effective as over-the-counter anti-inflammatory medications. Moreover that the spice may also be helpful in treating osteoarthritis, viral and bacterial infections, stomach ulcers, cancer and other conditions. And because of its antioxidant properties its even being called “the natural remedy of the century.”

Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis
The American Society for Biochemistry and Molecular Biology, July 2017
This approach revealed that a curcumin-based intervention shifts the oncogenic RAS-induced MEK/ERK pro-proliferative pathway toward p38MAPK/JNK1 pro-death signaling.

Curcumin pretreatment protects against PM2.5‑induced oxidized low‑density lipoprotein‑mediated oxidative stress and inflammation in human microvascular endothelial cells
Molecular Medicine Reports, July 2017
Curcumin induced NF‑κB, cell adhesion molecule 1 and vascular cell adhesion protein 1 expression. Thus, curcumin treatment may reduce PM2.5‑induced oxidative stress and inflammation in HMEC‑1. In summary, it was indicated that the effects of PM2.5 are associated with oxLDL via the NF‑κB signaling pathway, thereby inducing PM2.5 mediated oxidative and inflammatory responses. The results also suggested that curcumin may be able to reduce the oxidative and inflammatory effects of PM2.5 in HMEC‑1.

Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1
Experimental and Therapeutic Medicine, July 2017
Treatment with curcumin effectively reduced the brain injury score, increased myelin basic protein (MBP) expression and increased the quantity of neuronal cells in neonatal rats with hypoxic‑ischemic brain injury. Furthermore, treatment with curcumin significantly attenuated the changes in SOD activity and MDA levels and suppressed the iNOS protein expression induced in neonatal rats by hypoxic‑ischemic brain injury. Treatment with curcumin significantly increased Nrf2 and HO‑1 expression in the neonatal rats with hypoxic‑ischemic brain injury. The present study indicated that curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through the induction of Nrf2 and HO‑1.

Turmeric and Curcumin: A Primer
Psychology Today, June 2017
According to lab studies, there is evidence that turmeric curcumin may help both prevent and treat certain cancers, including: prostate, breast, skin, lung, pancreatic, and colon cancers.[1,14] It is also useful in the treatment of the symptoms and inflammation associated with chemotherapy for the treatment of cancer. (Goel, 2017) There are over 2,000 published studies on the subject, and the general centire onclusion is that curcumin supplementation may be beneficial for both cancer prevention and better treatment results.[14] In this sort of situation, taking pure curcumin extract instead of turmeric is preferred, because of the dosage requirements for maximum benefit. Many of these studies in the laboratory have shown that curcumin can actually stop cancer cells from dividing.[14] Cancer occurs when the DNA in cells get damaged, which causes them to divide uncontrollably, forming tumors. These can spread across your body if left untreated.[15] Keeping these cells from dividing helps stop cancer development in its tracks. Curcumin has also been shown to trigger programmed cell death, or apoptosis. This is a healthy and natural way for our bodies to eliminate damaged cells, and it’s helpful for getting rid of cancer cells. In many ways, curcumin is a good adjunct to chemotherapy. There have been no reported toxicities associated with curcumin consumption in this setting, and significant benefit. (Goel, 2017) For many people, this is an extremely attractive option when dealing with cancer treatment. Medicinal Uses for Turmeric Curcumin But as impressive as the results are in those undergoing cancer treatment and chemotherapy; the medicinal uses of turmeric are broad. It has been shown to alleviate pain and improve knee functioning in patients with osteoarthritis.[1] Many people suffer from arthritis, which involves inflammation of the joints. It can cause not only pain and swelling, but also limited mobility.[16] A study of 107 participants found that curcumin had roughly the same effect on patients as ibuprofen.[17] Turmeric is also able to assist in maintaining a healthy digestive tract as well. Its medicinal properties help regulate healthy digestion. Turmeric is especially effective against diarrhea from many causes, including infection, or inflammatory diseases like irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD) like Crohn’s disease or ulcerative colitis. One study on turmeric’s effect on ulcerative colitis showed that patients who consumed turmeric curcumin had significantly lower relapse rates than patients who did not consume it. This was a double-blind placebo-controlled study, which is the gold standard of clinical study design and methods; and one of the most reliable scientific ways to gather scientifically valid information.[24] Another sign of turmeric curcumin’s major health benefits is the fact that rural India’s population houses the lowest rates of Alzheimer’s disease (AD) in the entire world.[32] Adults in India are 4.4 times less likely to develop AD than comparably aged cohorts in other industrialized countries. Epidemiological and animal studies suggest an important role for turmeric and curcumin in potential prevention and treatment of neurodegenerative diseases like Alzheimer’s disease. (Ringman, Frautschy, Cole, Masterman, & Cummings, 2005, ) (Sikora, Scapagnini, & Barbagallo, 2010)

Curcumin induces apoptotic cell death in human pancreatic cancer cells
Oncology Letters, June 2017
The natural compound curcumin has previously been reported to inhibit pancreatic cancer cell growth. miR‑340 was identified to be significantly upregulated following curcumin treatment. In addition, treatment with curcumin or miR‑340 induced pancreatic cancer cell apoptosis, whereas silencing endogenous miR‑340 significantly inhibited the proapoptotic effect of curcumin. Furthermore, curcumin treatment significantly reduced XIAP expression, an effect that was rescued by treatment with anti‑miR‑340. The results of the present study suggest that the miR‑340/XIAP signaling pathway is a downstream target of curcumin that mediates its proapoptotic effects on pancreatic cancer cells. This may provide the basis for novel treatment strategies for patients with pancreatic cancer.

Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells
Oncology Reports, June 2017
Curcumin possesses an anticancer effect against a wide assortment of tumors with selective cytotoxicity for tumor cells. Our results demonstrated that curcumin inhibited the viabilities of gastric cancer cell lines BGC-823, SGC-7901 and MKN-28 in both a time- and dose-dependent manner. In addition, curcumin treatment induced gastric cancer cell apoptosis in a dose‑responsive manner. Western blotting of apoptosis‑related proteins further confirmed the pro-apoptotic potential of curcumin. After exposure to curcumin, a robust induction of autophagy was observed in gastric cancer cells, which was characterized by the formation of acidic vesicular organelles (AVOs), conversion of LC3-I to LC3-II and an increase in the levels of autophagy‑related proteins. Activation of the PI3K/Akt/mTOR signaling pathway was suppressed in gastric cancer cells with curcumin treatment. Collectively, our findings provide new evidence that curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells in vitro. Autophagy inhibitor treatment may provide a novel and effective strategy for improving the anticancer effect of curcumin against gastric cancer.

Turmeric (Curcumin),The Healing Root
blastingnews.com June 2017
Curcumin or curcuma longa, is a powerful antioxidant, adaptogen, antiviral, antibacterial, anti inflammatory, anti carcinogen and contains many beneficial vitamins and minerals including zinc, protein, niacin, fibre, vitamin C, vitamin E, vitamin K, iron and magnesium. Turmeric according to over 6000 #Peer Reviewed scientific studies, is beneficial for all sorts of ailments including inflammation, skin disorders, gastrointestinal disorders such as IBS, arthritis, viral infections, nausea, hormonal imbalances, obesity, hypertension, glaucoma, Helicobacter pylori, diabetes, high cholesterol, cancer and depression.

Antitumor effects of curcumin in human bladder cancer in vitro
Oncology Letters, June 2017
Curcumin was identified to decrease the growth of T24 and 5637 cells in a dose‑ and time‑dependent manner. The present study confirmed that curcumin is able to inhibit cell migration and promote apoptosis of bladder cancer through suppression of matrix metalloproteinase signaling pathways in vitro. The anticancer effects of curcumin on bladder cancer cells may benefit clinical practice in the future.

JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells
Experimental and Therapeutic Medicine, June 2017
In the current study, it was determined that curcumin was able to significantly induce apoptosis, and lead to autophagy in MG63 cells. Notably, inhibition of apoptosis enhanced curcumin‑induced autophagy due to upregulation of the c‑Jun N‑terminal kinase (JNK) signaling pathway. This finding was confirmed by the use of JNK‑specific inhibitor, SP600125. Furthermore, our data showed that curcumin‑induced apoptosis was increased when autophagy was completely inhibited by 3‑methyladenine in MG63 cells. These results suggest that autophagy may have an important role in resistance to apoptosis when MG63 cells are incubated with curcumin. Thus, these results provide important insights into the interaction between apoptosis and autophagy in osteosarcoma cells and clinical treatment strategies using curcumin.

Compound in turmeric found to suppress viruses, including hepatitis, herpes, chikungunya, influenza-A, HIV and HPV
Natural News, June 2017
The turmeric compound curcumin was found to effectively suppress a large number of viruses, recent studies showed. The compound was previously known to defer cancer growth, resolve Lichen Panus, reduce type-2 diabetes and prevent Alzheimer’s disease and dementia onset. However, a new article published in GreenMedInfo.com listed several other studies indicating that the compound was able to inhibit the growth of a plethora of viruses including zika virus, hepatitis, herpes, chikungunya virus, influenza-A, HIV and HPV. Curcumin was found to affect the virus; ability to bind with other cells. Another study published in the journal Gut showed that curcumin hindered the hepatitis C virus from entering the human liver cells. According to the researchers, this effect proved especially beneficial — as exposure to the HCV virus caused severe liver disease and was known to affect more than 160 million people around the world. Membrane fluidity experiments indicated that curcumin affected the fluidity of the HCV envelope resulting in impairment of viral binding and fusion. Curcumin has also been found to inhibit cell-to-cell transmission and to be effective in combination with other antiviral agents," the researchers concluded. Turmeric compound impedes more viruses Curcumin was also known to suppress the influenza-A virus in a number of studies. Researchers at the Graduate Institute of Microbiology and Public Health at the National Chung Hsing University in Taiwan found that the turmeric compound interfered with the virus' haemagglutination activity by blocking its ability to bind with red blood cells in patients. In addition, a study published in the Italian Journal of Biochemistry revealed that curcumin prompted hemeoxygenase-1 gene stimulation in the hippocampus of the brain. In turn, this activation triggered the production of bilirubin, a potent antioxidant essential for the immune system’s health. According to researchers at the Michigan State University, curcumin inhibited the herpes virus from spreading by affecting its early gene expression. “Curcumin is a potent compound with various biological properties. We have shown that curcumin significantly affects HSV-1 IE gene expression which thereby diminishes the ability of the virus to launch the lytic infectious cycle,” the researchers wrote. A study published in the Asia Pacific Journal of Cancer Prevention also found that curcumin was able to clear human papillomavirus in women. As part of the study, researchers at the Chittaranjan National Cancer Institute in India examined 287 HPV-positive women. The experts noted that women who were given curcumin-based treatments had HPV clearance rates between 81 percent and 87 percent.

Effective Natural Pain Relief for Fibromyalgia
nationalpainreport.com June 2017
More recently researchers have called curcumin, the active ingredient in turmeric, the “herbal ibuprofen.” [https://www.ncbi.nlm.nih.gov/m/pubmed/7390600/] One study found that curcumin was actually more effective at reducing pain and swelling in arthritic joints than anti-inflammatory medications. [http://onlinelibrary.wiley.com/doi/10.1002/ptr.4639/abstract;jsessionid=A768F9AF39A7EE0BC525EC80EC1A6861.f04t04]

Curcumin touted for metabolic benefits in people with fatty liver disease: RCT data
Drug Research, June 2017
Curcumin is a dietary polyphenol with lipid-modifying, antioxidant and anti-inflammatory properties. Supplementation with curcumin was associated with a reduction in body mass index (−0.99±1.25 vs.  − 0.15±1.31 in the curcumin and placebo groups, respectively; p=0.003) and waist circumference (−1.74±2.58 vs. −0.23±3.49 in the curcumin and placebo groups, respectively; p=0.024). Ultrasonographic findings were improved in 75.0% of subjects in the curcumin group, while the rate of improvement in the control group was 4.7% (p<0.001). Serum levels of aspartate aminotransferase and alanine aminotransferase were reduced by the end of trial in the curcumin group (p<0.001) but elevated in the control group (p<0.001). Curcumin was safe and well tolerated during the course of trial. Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.

Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage
Nutrients, June 2017
Curcumin, the active substance of Curcuma longa which is attributed most of the beneficial properties of turmeric, is chemically classified among the polyphenols. The many beneficial properties attributed to curcumin, as antioxidant, anti-inflammatory, anti-infective, anti-tumor, and preventive agent, are closely correlated with each other and could be associated with the ability to modulate the molecules involved in inflammation, programmed cell death, and morphology.In the present work, we demonstrated that pre-treatment with curcumin is able to reduce the levels of apoptosis in intestinal epithelial cells exposed to IFNγ.

Can turmeric help manage diabetes? What the evidence says
WXYZ Detroit, June 2017
Research focuses on the main component of turmeric called curcumin. A review of 13 years of research suggest curcumin may help in different ways. Adding it to your diet may reduce your chance of developing diabetes as curcumin appears to improve the cells that create insulin in the pancreas. Taking curcumin orally may reduce blood sugar levels, however more research is needed in humans. Other studies have shown those with prediabetes may not develop full diabetes when taking curcumin in capsule form.Taking curcumin may also help to prevent diabetic-related nerve damage, prevent diabetic cataracts and kidney disease.

Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
Nature.com June 2017
Curcumin exerts anti-inflammatory effects in DSS-induced colitis

Turmeric: From humble root to golden goddess
Vancouver Sun, June 2017
The active ingredient, curcumin has also been investigated by western science as a cancer-fighting agent. Studies have shown that curcumin is an anti-cancer agent and an anti-inflammatory. It inhibits an enzyme called COX-2 that is activated in various inflammation cascades. It works similarly to non-steroidal anti-inflammatory drugs.

Anticancer effect of curcumin inhibits cell growth in breast cancer cell
Oncology Letters, May 2017
Curcumin is a polyphenol extracted from turmeric, which that belongs to the Zingiberaceae family. Curcumin has numerous effects, including anti-inflammatory, antitumor, anti‑oxidative and antimicrobial effects. Curcumin inhibited cell viability and induced cytotoxicity of MCF‑7 cells in a concentration‑ and time‑dependent manner, by inducing apoptosis and increasing caspase‑3/9 activities. In addition, curcumin downregulated miR‑21 expression in MCF‑7 cells by upregulating the PTEN/Ak
t signaling pathway. The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth.

How Turmeric Shows Great Promise as a Natural Remedy for the Prevention and Healing of Symptoms of Type 2 Diabetes
EmaxHealth, May 2017
The science on curcumin, an Indian spice and anti-inflammatory has shown promise in reducing and even preventing complication of diabetes with it's effects on insulin resistance and by regulating blood sugar. The systematic review published in the peer-reviewed journal, Evidence-Based Complementary and Alternative Medicine looked at curcumin and its effect on diabetes in the prevention and treatment of diabetes and its associated disorders. The review concluded that curcumin could favorably affect most of the leading aspects of diabetes, including insulin resistance, hyperglycemia, hyperlipidemia, or high concentrations of lipids in the blood, and islet apoptosis and necrosis, or organ failure. In addition, curcumin showed promise in preventing the injurious complications of diabetes.

Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism
Complementary and Alternative Medicine, May 2017
Curcumin plays a significant therapeutic role in attenuating brain damage that has been induced by prenatal VPA exposure in rats; however, its therapeutic role as a dietary supplement still must be certified for use in humans.

Curcumin: A naturally occurring modulator of adipokines in diabetes
Journal of Cellular Biochemistry, May 2017
Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes.

This Could Be The Greatest Spice For Men's Health
Huffingtonpost.com May 2017
Curcumin extracts have been shown to reduce the pain and improve function in knee osteoarthritis “with an efficiency equivalent to ibuprofen, but with fewer gastrointestinal side effects.” Combining curcumin and Boswellia serrata also has been shown to be more effective than the COX-2 inhibitor celecoxib in the treatment of osteoarthritis.A number of studies have found that turmeric/curcumin is effective in reducing depression, especially mild cases. One study noted that patients with major depressive disorder who took curcumin fared just as well as their peers who took Prozac (fluoxetine). A more recent meta-analysis of six clinical trials reported that curcumin “appears to be safe, well-tolerated, and efficacious among depressed patients.” Curcumin has been shown to improve glucose tolerance in animal research as well as significantly lower hemoglobin A1c in patients with type 2 diabetes. Free-radical fighting antioxidants called curcuminoids are abundant in turmeric. Curcumin is the most prominent of these polyphenols. In addition to helping destroy disease-causing free radicals, curcuminoids also facilitate the activity of antioxidant enzymes (e.g., catalase, superoxide dismutase). Antioxidants can help slow the aging process, protect against chronic disease (including cancer and heart disease), reduce oxidative stress, and fighting inflammation.

Healing The Body, Naturally
Elle Magazine, May 2017
There is good research to support the ability of curcumin to reduce cellular damage and risk of chronic disease; decrease pain and inflammation (effects have been shown to be similar to paracetamol); [and] it may reduce the risk of heart disease. Curcumin intake is also associated with a decreased risk of colon cancer and reduced symptoms associated with ulcerative colitis.

Curcumin sensitizes prostate cancer cells to radiation
J Drug Target, May 2017
Curcumin has been reported as a radiosensitizer in prostate cancer. Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.

Turmeric: The Golden Herb
Hamlet Hub, May 2017
Anti-inflammatory: the constituent curcumin is responsible for the anti-inflammatory action thus reducing inflammation and making it useful in the treatment of muscle pain, joint pain, arthritis, fibromyalgia, ulcerative colitis, Chrohn’s disease, rheumatoid arthritis, cancer, irritable bowel syndrome (IBS), headaches, SLE, bronchitis, autoimmune diseases, cardiovascular diseases. Anti-oxidant: curcumin can protect the DNA against breaks and oxidation which makes it useful in the treatment of different types of cancer, autoimmune diseases, cardiovascular health, protective for the body. Anti-neoplastic: curcumin has been proven to have anti-cancer properties in the body. Either as part of a treatment protocol or as preventative. Lipid modulation: curcumin has shown positive results in decreasing total plasma cholesterol levels, decreasing LDL, decreasing triglycerides and increasing HDL levels. It also helps decrease inflammation in the vessels hence improving cardiovascular health and decreasing risks. Anti-platelet: curcumin has been shown to prevent thrombus formation from platelet aggregation hence being beneficial for cardiovascular health. Anti-bacterial: curcumin has also shown effectiveness with treating infections. Anti-hepatotoxic: curcumin has been shown to stimulate Phase II detox activity in the liver helping excrete toxins out of the body.

New Prospects for Treating Malignant Mesothelioma with Curcumin
SurvivingMesothelioma.com May 2017
There is more evidence that the active ingredient in turmeric may have the power to help combat malignant mesothelioma. A new French study on curcumin finds that the compound not only slowed the growth of one of the rarest types of mesothelioma tumor cells in the laboratory but also reduced total tumor mass in lab rats in just two weeks. Curcumin, the plant polyphenol that gives turmeric its yellow hue and pungent flavor, has been the subject of numerous malignant mesothelioma studies in recent years, in part because of its powerful anti-inflammatory properties. In addition, curcumin appeared to attract cancer-fighting CD8+ T lymphocytes to the area which clustered around small residual mesothelioma tumors in the peritoneal cavity after treatment. “These data open up interesting new prospects for the therapy of sarcomatoid mesothelioma with curcumin and its derivatives,” concludes Dr. Pouliquen. Earlier this year, scientists in the Department of Experimental Medicine at the University of Rome conducted a similar experiment and that found that intraperitoneal curcumin extended survival in mice with mesothelioma. In 2015, mesothelioma researchers with Flinders University in Australia determined that curcumin had the ability to keep mesothelioma tumors from giving rise to their own new blood vessels. That study suggested that curcumin could become a supplemental treatment for certain mesothelioma patients.

Why are so many scientists studying this spice?
Stuff, May 2017
Curcumin is also an antioxidant which helps prevent free radical damage -studies have found that people with depression have greater free radical damage to brain cells. Curcumin appears to help protect brain cells - which is why other studies are looking at whether curcumin might help prevent dementia. There's a huge demand for an anti-inflammatory substance that doesn't have side effects and curcumin stands out. More than 60 studies of curcumin worldwide are looking at its potential role with a number of cancers.

Curcumin improves bone density by up to 7%, study reveals
Daily Mail, May 2017
A compound in turmeric, known as curcumin, is thought to balance out cells that remove ageing parts of bone before it is replaced, according to previous findings. Curcumin blocks rogue proteins called beta amyloid, which clump together and destroy neurons, according to researchers from Edith Cowan University, Perth. In the study 96 participants aged between 40 and 90 were given either a daily placebo or 1,500 mg of curcumin for 12 months. In tests of verbal and memory skills, those taking the dummy pill suffered a decline in mental function after just six months that was not observed in those having curcumin.

Curcumin exerts antitumor activity
OncoTargets and Therapy, May 2017
Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. Curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target. Our results identified that upregulation of miR-7 by curcumin could benefit nasopharyngeal carcinoma patients.

Curcumin, Found in Turmeric Plants, Seen to Shrink Sarcomatoid Mesothelioma Tumors in Rat Study
MesotheliomaResearchNews.com May 2017
When curcumin was administered to rats one week after the injection of tumor cells, the size of the tumors dropped dramatically by the 16th day. The researchers also found that curcumin appeared to stimulate the immune system, observing a type of white blood cell surrounding remaining tumors in rats treated with curcumin. This white blood cell, known as a CD8+ T-cell, is known to kill cancer cells under the right conditions. “In conclusion, these data open up interesting new prospects for the therapy of malignant mesothelioma with curcumin, in particular the sarcomatoid subtype,” the research team wrote. “Future studies will determine the best sequence/dose(s) of curcumin or its many derivatives to use to optimize the specific immune response directed against M5-T1 cells. A complementary approach would also be the combination of curcumin/derivatives with current chemotherapeutic agents to reduce the dose used and the associated systemic toxicity of the latter.”

Superfood focus: Healthy properties give turmeric a golden touch
The National, May 2017
The benefits are primarily due to curcumin, the active compound in turmeric that is not only responsible for its bright hue, but also a powerful antioxidant with anti-inflammatory and antibacterial qualities.

Turmeric may help ease the symptoms of Lyme disease
EmaxHealth, May 2017
The secret is turmeric’s curcumin, a plant chemical that has many healing capabilities, and has been scientifically proven to counter skin rashes, fatigue, bacterial infections and pain in joints and muscle, all of which are symptoms of Lyme disease. Research has proven that curcuminoids can improve the pain and physical function of patients suffering from knee osteoarthritis, an extremely debilitating and painful disease that is characterized by the degeneration of joint cartilage and the underlying bone causing inflammation. In an animal model study on immunologically induced fatigued mice, scientists were able to observe that oral administration of curcumin, reduced oxidative stress, increased in mobility ( mice were less tired), and also reduced abnormal sensitivity to pain. Curcumin protects skin by quenching free radicals and reducing inflammation through nuclear factor-KB inhibition. A study trying to establish the effectiveness of curcumin against 4 types of bacteria, namely Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginos, has confirmed that turmeric is effective against all the bacterias tested and the extent of bacteria killing showed an increase with dosage and incubation time.

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.
BMC Complementary and Alternative Medicine, May 2017
Resveratrol and curcumin, as natural flavones products, have good therapeutic effect in acute and chronic inflammation; on the other hand, tetramethylpyrazine (TMP) has angiogenesis and vessel protection effect as well as anti-inflammatory function. In this paper, the anti-inflammatory effect of the tetramethylpyrazine, resveratrol and curcumin (TRC) combination in acute and chronic inflammation was reported in vivo.

Curcumin Inhibits Apoptosis of Chondrocytes
Nutrients, May 2017
Osteoarthritis (OA) is an inflammatory disease of load-bearing synovial joints that is currently treated with drugs that exhibit numerous side effects and are only temporarily effective in treating pain, the main symptom of the disease. Curcumin, the principal curcuminoid and the most active component in turmeric, is a biologically active phytochemical. Evidence from several recent in vitro studies suggests that curcumin may exert a chondroprotective effect through actions such as anti-inflammatory, anti-oxidative stress, and anti-catabolic activity that are critical for mitigating OA disease pathogenesis and symptoms. Curcumin should be explored further for the prophylactic treatment of osteoarthritis in humans and companion animals.

Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells
Oncotarget, May 2017
Studies have demonstrated that curcumin exerts its tumor suppressor function in a variety of human cancers including glioma. Curcumin significantly inhibited cell growth, suppressed cell migration and invasion, induced apoptosis and cell cycle arrest in glioma cells. Curcumin exerts its antitumor activity through inhibition of Skp2 pathway. Collectively, our findings suggest that targeting Skp2 by curcumin could be a promising therapeutic approach for glioma prevention and therapy.

Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma.
Oncotarget, May 2017
The treatment of tumor-bearing rats with 1.5 mg/kg curcumin on days 7, 9, 11 and 14 after tumor challenge dramatically reduced the mean total tumor mass at day 16. .These data open up interesting new prospects for the therapy of sarcomatoid mesothelioma with curcumin.

Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts
International Journal of Molecular Medicine, April 2017
Curcumin suppress cell proliferation in the pterygium by inducing HPF apoptosis and inhibiting VEGF expression. Thus, curcumin has potential for use as a novel agent for the treatment of pterygium in the near future.

History and Origins of Turmeric
DESIblitz, April 2017
Elderly villagers in India appear to have the lowest rate of Alzheimer’s disease in the world, and researchers have speculated that the anti-inflammatory effects of curcumin may be partly responsible,” states Dr Andrew Weil.  Curcumin may kill and prevent cancer cells of the breast, bowel, stomach and skin from growing. Curcumin also acts as an antioxidant, which protects the body from free radical damage (free radicals contribute to increased cancer risk).  Curcumin can help sustain healthy blood pressure. This ultimately, promotes heart health and reduces the likelihood of developing heart disease. The spice may also prevent the clogging of arteries, which is a risk factor for strokes and heart attacks. Curcumin also seems to reduce the risk of developing diabetes among pre-diabetic individuals.

Medicinal Herbs for Cancer
Liberty Voice, April 2017
Curcumin, in turmeric, is a powerful anti-inflammatory agent. Additionally, it contains broad anti-parasitic and antimicrobial features. Turmeric has properties to support the fight against cancer by preventing cells from dividing quickly to form tumors, and prevents the development of capillaries that feed tumors. The active ingredient in turmeric, curcumin, kills diseased cells without damaging the healthy cells. It does this by removing the activation path of most diseases caused by inflammation, which is linked to cancer. Turmeric is effective in preventing cancer of the stomach, lung, colon, breast, and skin.

Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation
School of Pharmaceutical Sciences, São Paulo State University, April 2017
Treatments with mixtures of curcumin and lycopene or bixin had combined effects, decreasing biomarkers of carbohydrate and lipid disturbances (curcumin effect), increasing the HDL levels (carotenoids effects) and mitigating oxidative stress (curcumin and carotenoids effects). The combined effects also led to prevention of the LDL oxidation, thereby mitigating the cardiovascular risk in diabetes. These findings provide evidence for the beneficial effect of curcumin and carotenoid mixtures as a supplementation having antioxidant and antiatherogenic potentials, thus appearing as an interesting strategy to be studied as a complementary therapy for diabetic complications.

Proven Health Benefits of Turmeric and Dosage
Belair Daily, April 2017
Turmeric has a powerful active ingredient called curcumin that is known to be a natural antioxidant and has been used for generations as a treatment for digestive and liver problems. Now, turmeric and diabetes have been linked through several studies.

Foods that flush the body
JamaicaObserver.com April 2017
Curcumin is a component that stimulates the production of bile by the gall bladder. Bile is used by the kidneys, not just to eliminate toxins, but also to restore and revitalise liver cells that are central to the deconstruction of harmful compounds.

The science on curcumin
Mind Body Green, April 201
Curcumin is a powerful antioxidant within turmeric and the center of most of the research about turmeric. Because of the evidence of curcumin's powerful anti-inflammatory benefits, it's extracted and standardized in higher doses to be put into supplements. What's the science on curcumin? The commonality between just about all the research done on turmeric and curcumin boils down to one thing: inflammation. Inflammation is a buzzword of late and something we have talked about in functional medicine for years. Curcumin and turmeric are known for their ability to tame chronic inflammation; here's a roundup of health problems for which they seem to be beneficial: Alzheimer's Autoimmune inflammation Brain inflammation (brain fog and memory loss) Cancer Candida Cataracts Depression Diabetes Erectile dysfunction Gallbladder problems Heavy metal toxicity Inflammatory bowel disorders Insulin resistance Lupus Pneumonia Rheumatoid arthritis Viral infections Weight-loss resistance.

10 Ways Turmeric Might Be Superior To Modern Medicine
The Alternative Daily, April 2017
The active compound in turmeric — curcumin — is on par with over-the-counter anti-inflammatories, without all the harmful side effects. In one study, researchers tested stressed-out lab rats displaying depression-like symptoms along with adrenal issues, caused by a prolonged elevation in stress hormones. Surprisingly, they found that curcumin helped to alleviate negative physiological effects. “These results provide compelling evidence that the behavioral effects of curcumin in chronically stressed animals, and by extension humans, may be related to their modulating effects on the HPA axis and neurotrophin factor expressions,” wrote the authors. Several studies have found that curcumin can significantly inhibit the development and movement of cancer cells through the body. It does this by reducing the growth of new blood vessels in tumors, called angiogenesis. Curcumin may also contribute to the cancer cell death directly.

Anti-inflammatory efficacy of turmeric oil and curcumin in colitis
Nature.com April 2017
Considering that curcumin is a readily available, safe and a cost-effective botanical, there is a growing interest in exploring its clinical efficacy individually or as an adjunctive treatment for managing and/or treating UC and subsequently improving the overall quality of life for patients with this inflammatory disease. Although curcumin is a well-established anti-inflammatory agent, the exact mechanism(s) by which it attenuates inflammatory burden in diseases such as UC remains unclear. Herein, we demonstrated that curcumin exhibited significant anti-inflammatory effects in a mouse model of dextran sodium sulfate (DSS)-induced colitis.

Go for the gold with turmeric
SC Now, April 2017
Turmeric contains a phytochemical nutrient named curcumin, which is an antioxidant known for anti-inflammatory, anti-microbial and anti-cancer properties. With more than 100 clinical studies, curcumin has been shown to be active against several chronic diseases, including various types of cancers, diabetes, obesity, cardiovascular, pulmonary, neurological and autoimmune diseases, such as inflammatory bowel disease.

Superherbs
Rescue, April 2017
Turmeric contains Curcumin as the main active ingredient, which has antioxidant and anti-inflammatory properties. As an anti-inflammatory curcumin is powerful, matching the effectiveness of some drugs. Low level inflammation is involved in almost every chronic condition; cancer, Alzheimer’s, metabolic syndrome as examples. Curcumin actually targets the inflammatory pathway at a molecular level. In addition to protecting against free radical damage (antioxidant) and chronic inflammation (anti-inflammatory), curcumin has shown promise in treating depression and could be considered an anti-ageing supplement.

Clinical Use of Curcumin in Depression: A Meta-Analysis
Journal of the American Medical Directors Association, March 2017
Six clinical trials with a total of 377 patients were reviewed, comparing the use of curcumin to placebo. In patients with depression, the pooled standardized mean difference from baseline Hamilton Rating Scale for Depression scores (pooled standardized mean difference −0.344, 95% confidence interval −0.558 to −0.129; P = .002) support the significant clinical efficacy of curcumin in ameliorating depressive symptoms. Significant anti-anxiety effects were also reported in 3 of the trials. Notably, no adverse events were reported in any of the trials. Most trials had a generally low risk of bias, except for an open trial of curcumin and a single-blinded study.

10 Health Benefits Of Turmeric And Curcumin You Need To Know
Global Health Clinics, March 2017
Curcumin has been shown to reduce inflammation by lowering levels of two inflammation enzymes in the body. Inflammation is a complicated immunological process that takes places in the cell. Curcumin works at a cellular level to block out bioactive molecules that trigger the inflammation process common in most chronic diseases such as arthritis and gastrointestinal disorders. One of the mechanisms behind ageing and many diseases is oxidative damage. Curcumin is a potent antioxidant that can neutralize free radicals in the body helping to prevent aging and disease. It can also stimulate the body’s own antioxidant properties. Brain derived neurotrophic factor (BDNF) is a type of growth hormone that functions in the brain. Curcumin has been shown to increase neurogenesis, potentially via modulation of the hypothalamic-pituitary-adrenal (HPA) axis and by increasing (BDNF) production in the brain. Depression has been linked to reduced levels of BDNF. Studies have confirmed that curcumin, found in turmeric, has a similar effect as antidepressants on patients suffering from depression by boosting levels of BDNF. Curcumin has also been shown to boost the brains neurotransmitters serotonin and dopamine. Due to its high antioxidant and anti-inflammatory properties curcumin can lower the chance of heart diseases. Curcumin improves the lining of the blood vessels, regulate blood pressure and reduce blood clotting. One study found that curcumin is just as effective as exercise at improving blood flow to the heart. Curcumin contains anti-cancer compounds that can strengthen the body providing cancer protection. Given that curcumin is a potent anti-inflammatory, it makes sense that it could help with arthritis as it has a positive effect on joint swelling and pain-reduction. Some studies suggest that patients with rheumatoid arthritis, curcumin was even more effective than an anti-inflammatory drug.Curcumin is known for its anti-inflammatory properties that can pass through the blood/brain barrier, unlike other substances and has been shown to lead to various improvements in the pathological process of Alzheimer’s disease. Due to all of curcumins potent health benefits listed above such as reducing inflammation in the body and being a potent antioxidant curcumin provides compounds that kill off free-radicals that cause the ageing process and prevent disease.

Spice Compound Extends Mesothelioma Survival in Mice
Surviving Mesothelioma, March 2017
Curcumin has been the subject of numerous mesothelioma studies. The latest one, conducted by scientists at the Department of Experimental Medicine at the University of Rome, finds that the compound has the power to not only kill mesothelioma cells in the lab, but to also extend survival in mice infected with the asbestos cancer.

The ancient wisdom of turmeric
Lacrosse Tribune, March 2017
“Curcumin is the compound in turmeric that gives it its bright yellow hue,” says Rachael Hartley, R.D., L.D., C.D.E. It has been shown to block enzymes in the inflammatory pathways, potentially fighting inflammation at the molecular level, and it’s being actively studied for relief of swelling and pain in both osteoarthritis and rheumatoid arthritis. Curcumin is also a powerful antioxidant, and lab and animal studies have reported that curcumin inhibits cancer at multiple stages of development, although we don’t yet know how that might work in the body. The anti-inflammatory and anti-oxidant effects could help reduce heart disease risk, and this potent turmeric component also may help keep the lining of veins and arteries healthy and reduce cholesterol levels.

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
Drug Design, Development and Therapy, March 2017
Curcumin induces apoptosis and autophagy in different cancer cells. Moreover, chemical and biological experiments have evidenced that curcumin is a biologically active iron chelator and induces cytotoxicity through iron chelation. Our results indicate that curcumin induces apoptosis and protective autophagy in CRPC cells.

Turmeric’s anti-aging effects
EmaxHealth, March 2017
Recent studies have observed in animal and human trials that Turmeric’s natural chemical knows as Curcumin, (the yellow pigment from the rhizoma of Curcuma longa), exerts powerful anti-oxidant, photo-protective and anti - inflammatory activities. This leads scientists to believe that curcumin has anti-ageing effects. A review of the literature on the effects of Curcumin in the body, published by the journal of alternative medicine, found that a high dose of Curcumin is not toxic for humans. In one of the studies 25 subjects used up to 8000 mg of curcumin per day for 3 months, and five other subjects used 1125-2500 mg of curcumin, which was also found to be safe. There are three main aspects of ageing: oxidative stress, inflammation and sun damage. Experts at the Deparment of Neuroscience and Neurology in Finland, explain that during aging, adaptive immunity significantly declines, while innate immunity seems to be activated which induces a characteristic pro-inflammatory profile. The first way in which Turmeric works is by inhibiting the number of different molecules that play a role in inflammation. In 2010 an article published at Current Design, has measured the molecular targets of curcumin in the body. The researchers found that that curcumin directly affects a few major targets, such the NF-κB signaling pathways, which can in turn suppresses the pro-inflammatory state involved in the etiology of ageing and age-related diseases. Therefore, Curcumin’s anti- ageing results are compelling.

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice
Oncotarget, March 2017
Curcumin is a "multifunctional drug". Intraperitoneal administration of curcumin increased the median survival of C57BL/6 mice intraperitoneally transplanted with #40a cells and reduced the risk of developing tumors. Our findings may have important implications for the design of MM treatment using curcumin.

Turmeric is effective in treating various types of cancer
Kashmir Monitor, March 2017
Curcumin, the principal curcuminoid of turmeric, has been intensely studied as a cancer protective agent. Its potential has been tapped in head and neck cancers, breast, lung, gastro-intestinal cancer, ovarian cancer, melanoma, neurological cancers, sarcoma, leukemias and lymphoma.

Compound in Turmeric Shows Promise for Treating Mesothelioma
Mesothelioma.com, March 2017
Curcumin, a compound in the spice turmeric, has shown promise as a possible treatment for malignant mesothelioma. A recent study discovered the compound blocked intracellular degradation and activated the death of mesothelioma cells. Plus, it increased the survival of mice given the mesothelioma cell line.

Benefits of Turmeric
Verge Campus, March 2017
The compound curcumin is naturally occurring in turmeric, and it is responsible for the many benefits of the plant. However, curcumin makes up only around 3% of the make-up of turmeric by weight. For that reason, supplements are the best way to get curcumin in your system. Curcumin is proven to reduce chronic inflammation, helping to prevent its negative long-term effects. Curcumin happens to be a powerful antioxidant, capable of neutralizing free radicals. Curcumin also stimulates the production of our body’s own natural antioxidant enzymes.Studies have shown that curcumin can help prevent cancerous cells from growing, multiplying, and spreading. It has even been found to kill some cancerous cells. For example, in a study of 44 men with lesions in the colon, which could possibly turn cancerous, curcumin was administered. The men were given 4 grams of curcumen per day for 30 days. At the end of the trial, the amount of lesions had decreased by 40%. A controlled study took 60 patients and divided them into three groups. One group was given Prozac, the other Prozac and curcumin, and the third just curcumin. The purely curcumin group experienced positive benefits, but the most effective treatment was found in the combination of Prozac and Curcumin.In a study, patients with rheumatoid arthritis experience better results from taking curcumin supplements as opposed to arthritis medication. This is likely due to curcumin’s anti-inflammatory properties The active chemical in turmeric, curcumin, is a wonder-molecule. Its many uses testify to its presence in human culture and Ayurvedic traditions dating back thousands of years. Its potentials are continuing to be studied, so that in the future we may learn even more about this magical molecule.

Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network
Public Library of Science (PLOS) , March 2017
The present study was aimed to unravel the inhibitory mechanisms of curcumin for lung cancer metastasis via constructing a miRNA-transcription factor (TF)-target gene network. We suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.

The power of turmeric
inews880.com, March 2017
The active ingredient that we’re also concerned about – or really interested in – is actually curcumin. It’s the main active ingredient which holds the most inflammatory and anti-oxidant potential. The beautiful thing about turmeric is that in all the recent studies and journalism and medical information that we have, it’s really effective against inflammatory conditions, like arthritis.

This centuries-old spice is the superfood of 2017
USA Today, March 2017
Turmeric fights inflammation, helps balance blood sugar and cholesterol levels. The University of Maryland Medical Center said it has been used for centuries to battle medical conditions and research suggests it may help treat cancer and colitis.

Turmeric trumps meds
Mirror, March 2017
Turmeric contains curcumin, a power antioxidant which has antiinflammatory properties. It is loaded with dietary fiber, niacin and the vitamins C, E and K, as well as potassium, calcium, copper, iron, magnesium and zinc. It acts as an immuno-booster, and helps in developing resistance towards many bacterial, viral and fungal infections. It also works like a muscle-relaxant by neutralising the extra gases and toxins produced in the body. Being rich in fibre and an antiinflammatory agent, curcumin also helps in weight reduction by reducing hunger pangs and raising the metabolic rate.

Curcumin decreases malignant characteristics
BioMedCentral.com February 2017
These findings indicate that curcumin may be a safe future chemotherapeutic agent.

 Environmental Nutrition
Orlando Sentinel, February 2017
"Curcumin is the compound in turmeric that gives it its bright yellow hue," says Rachael Hartley, R.D., L.D., C.D.E. It has been shown to block enzymes in the inflammatory pathways, potentially fighting inflammation at the molecular level, and it's being actively studied for relief of swelling and pain in both osteoarthritis and rheumatoid arthritis. Curcumin is also a powerful antioxidant, and lab and animal studies have reported that curcumin inhibits cancer at multiple stages of development, although we don't yet know how that might work in the body. The anti-inflammatory and anti-oxidant effects could help reduce heart disease risk, and this potent turmeric component also may help keep the lining of veins and arteries healthy and reduce cholesterol levels.

Curcumin Is Associated with Downregulation of Cell Division Cycle 20 in Pancreatic Cancer
Nutrients, February 2017
Curcumin could be useful for the treatment of pancreatic cancer patients.

Turmeric and Curcumin
Food.ndtv.com February 2017
 Curcumin belongs to a family of chemicals that are known as curcuminoid and which have a bright yellow colour. It is this compounds that lends the distinctive colour to the spice. Curcumin was first identified as a compound back in 1815. Since then, there have been several studies conducted to learn more about its abilities. It is believed that curcumin works on multiple functions and processes at the same time which is why it has been touted to cure everything from pain and inflammation to fighting tumours and promoting brain health.

Cancer prevention
inUth.com February 2017
Curcumin with chemotherapy can treat bowel cancer cells. The results were based on a laboratory test that showed that the combined treatment killed more cancer cells than the chemotherapy alone.

How Turmeric Upgrades Your Organ Systems & Treats Cancer, Inflammatory Disease
Collective-Evolution.com February 2017
Researchers have found that curcumin has a positive effect on multiple systems in the body. For one, curcumin has been found to modulate around 700 of our genes. Furthermore, it modulates over 160 physiological pathways. Curcumin also regulates our cell membranes, allowing for more efficient transport of molecules in and out of the cell. But one of the most amazing aspects of curcumin is its positive effect on signalling molecules, which, if gone awry, can lead to chronic inflammatory responses, autoimmune responses, issues with DNA and RNA regulation, and more. In short, curcumin is a vastly important ingredient in the prevention of almost all types of diseases.

Inhibitory Effect of Astragaloside and Curcumin on Tumor Growth
Anticancer Research, February 2017
The combination of AS-IV and curcumin demonstrated significant synergistic effects on microvessel count as well as on expression of angiogenic and thrombosis-related factors and microRNAs. Conclusion: The present study indicates future clinical potential of combination therapy with AS-IV and curcumin.

Over 7,000 studies confirm turmeric’s health-protective effects
Natural News, February 2017
A 2015 review published by the journal Molecules states that curcumin — a key component of turmeric — can inhibit the initiation, progression and metastasis of a number of different kinds of tumors. The review authors also note that curcumin halts disease progression by inducing apoptosis, or cell death. The team notes that at the time their review was completed, some 6,850 studies of turmeric had been published, noting that many of these were indicative of the spice’s potential health benefits. In their conclusion, the authors write, “A plethora of in vitro and in vivo research together with clinical trials conducted over the past few decades substantiate the potential of curcumin as an anti-cancer agent.”

Active compounds in turmeric, onion help fight colon cancer
Business Line, February 2017
Global research studies in the past decade have also thrown up positive results on the impact of curcumin in preventing colon and breast cancers. In a clinical trial, researchers in the US have shown that people who eat large amounts of curries with ingredients like turmeric and an antioxidant found in Onions called quercetin have beneficial effects. There is a growing body of scientific literature from across the world, including studies from the Hyderabad-based National Institute of Nutrition, which highlight properties such as anti-inflammation, antioxidant and anti-tumour attributed to curcumin.

Turmeric compound may treat colon cancer
Kashmir Monitor, January 2017
The researchers found that combination of two plant compounds that have medicinal properties - curcumin and silymarin - holds promise in treating colon cancer. Curcumin is the active ingredient in the spice turmeric. The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death.

Health Benefits of Curcumin
foods4betterhealth.com January 2017
Turmeric spice contains the healing compound, Curcumin, and studies have proved that it is more advantageous than many prescription drugs. Curcumin has a good ability to control inflammation. Oncogene published the results of a study stating that among all the anti-inflammatory medications in the world, aspirin and ibuprofen are the least effective, while curcumin is the most effective. Inflammation causes diseases like cancer, ulcerative colitis, arthritis, high cholesterol, and chronic pain. With arthritis drugs (diclofenac sodium), people may develop a leaky gut and heart disease, whereas with curcumin, treatment is safe and doesn’t have any adverse side-effects. The countless benefits of curcumin helps to treat people suffering from different types of arthritis.

Spice health benefits
The Gazette, January 2017
The active ingredient in turmeric is a powerful antioxidant called curcumin. The American Cancer Society notes that a number of studies have found curcumin kills cancer cells in vitro and reduces the size of tumors in animals.

Curcumin improves glucose tolerance
Mol Nutr Food Res., January 2017
These findings demonstrate the biological function of curcumin as a GLP-1 secretagogue and the possible molecular target that mediates GLP-1 secretion. Increases in the secretion of endogenous GLP-1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes.

Health Benefits of Turmeric
Factskeeper.com January 2017
One recent study actually found that curcumin from turmeric was more beneficial than some medications in reducing oxidative stress in the body, inflammation in the body, and treating high cholesterol.

Turmeric, the spice of life
CBS News, January 2017
The very thing that makes turmeric so colorful -- a compound called curcumin -- is what some researchers say also makes it a powerful weapon against disease. Biophysicist Ajay Goel has been studying its medicinal qualities at Baylor University Medical Center in Dallas. “We’re doing clinical trials on Alzheimer’s disease, Parkinson’s disease, arthritis, diabetes,” said Goel. “And it seems to have an effect on all these different conditions?” Cowan asked. “Absolutely. It is such a wonderful compound that has been shown to work in every single instance people have tried.” Goel says thousands of studies have shown that, in a concentrated-enough dose, the curcumin in turmeric has not only proven to be an effective antioxidant and anti-inflammatory, but also shows promise in preventing and even treating something as serious as cancer.

Study finds spices can help fight cancer
ABC News, January 2017
There's now a volume of scientific evidence showing that curcumin is a safe, and powerful anti-inflammatory. "What we were missing at that time, we didn't have the science behind it, we just knew that somebody took this and felt better," said Dr. Goel. After seeing an integrative medicine physician, she started on curcumin capsules daily to reduce inflammation. "So I tried it and it worked. There was nothing else I changed. No other variables whatsoever," Jones said. "It's a passion for me and I feel privileged in a sense that I can see the science and I can see the anecdotal evidence, and I can see the limitations. I can see the positive things," said Dr. Goel. Like possible cancer prevention someday on a plate. A previous study by Professor Goel found that taking curcumin while undergoing chemotherapy increased the effectiveness of the treatment. If you are shopping for supplements and want the full benefit of curcumin, buy curcumin capsules, not turmeric. Remember turmeric is the spice, curcumin is the medicine.

The medicinal properties of turmeric
Seattle Times, January 2017
The National Library of Medicine (PubMed.gov) contains thousands of research articles on turmeric or its active ingredient curcumin. That’s because there is intense interest in the medicinal properties of this Indian spice. Curcumin is being studied for its activity against psoriasis, diabetes, Alzheimer’s disease and a range of cancers. All of this research is being conducted in animal models, but the anti-inflammatory activity of curcumin has been shown to help nasal congestion in humans (Annals of Allergy, Asthma and Immunology online, Oct. 24, 2016). It also has been shown to help knee pain due to arthritis when taken as a supplement (Nutrition Journal, Jan. 5, 2016).

Curcumin sensitizes human gastric cancer cells
Chemical Biology Research Center, Wenzhou Medical University, December 2016
The combination of 5-FU and curcumin could be further developed as a potential therapy for human GC.

4 Ways Food Can Fight Muscle Soreness
IronMan.com December 2016
For centuries, curcumin has been prized in Asia for its purported benefits in health. Curcumin, like quercetin, has been investigated in a variety of exercise recovery models, including its impact on exercise-induced muscle soreness. A recent study compared the effects of 2.5 g curcumin or placebo taken twice daily for two days before and three days following a bout of heavy eccentric exercise. When subjects consumed curcumin, muscle soreness was lower at 24 and 48 hours after exercise with some evidence for enhanced recovery of muscle performance compared to placebo. In another study, subjects given 200 mg curcumin two times per day for 48 hours prior to and following a single bout of downhill running experienced less muscle soreness than subjects given placebo. Collectively, these findings suggest curcumin supplementation may dampen exercise-induced muscle soreness and support recovery.

Spice may help fight cancer
Vindi.com December 2016
The evidence is especially strong for curcumin, an active component of turmeric. It has the ability to interrupt metabolic pathways that cancer cells use to survive and spread (Anticancer Research, November 2016). Curcumin also may have activity against lung, breast, stomach, colorectal and uterine cancer.

The 7 Foods That Relieve Joint Pain
Tthe Weekly Challenger, December 2016
Curcumin, a compound found in turmeric, has been shown to help suppress cancer, reduce blood pressure, and have a positive impact on inflammation, just to name a few. One University of Arizona study found that the curcumin can help protect against joint deterioration and inflammation caused by rheumatoid arthritis. Another study researched how well ibuprofen eased pain over curcumin, and found that the benefits were about the same for both.

Study Finds the Spice Curcumin Fights Depression
MadeInAmerica.com December 2016
A new study, published online ahead of print in the Journal of Affective Disorders, finds that the spice curcumin, a derivative of turmeric, may be an effective treatment for depression. The study was a randomized, placebo-controlled trial (the gold standard methodology for medication studies). The researchers found that curcumin was better than a placebo treatment, and those with atypical depression were far more likely to improve.

 Compound in turmeric may treat colon cancer: study
The Hindu, December 2016
Researchers studied a line of colon cancer cells in a laboratory model. They found treating the cells initially with curcumin, then with silymarin was more effective in fighting cancer than treating the cells with either phytochemical alone. “The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death,” said Uthayashanker Ezekiel from Saint Louis University.

 The health benefits of tumeric
HanfordSentinel.com December 2016
Health benefits of curcurmin: Reduces whole body inflammation Reduces joint pain from arthritis Helps maintain healthy cholesterol levels Helps maintain body weight and may delay or reduce the onset of type 2 diabetes Reduces heartburn and stomach upsets Improves memory and brain function Good for skin problems Cancer prevention

Dietary inflammatory index and telomere length
American Society for Nutrition, December 2016
Lifestyle factors could affect the health and longevity of an individual by modifying telomere length (TL)12 (1), a molecular proxy for estimating cellular aging (2). In this context, several studies in humans have looked into the effects of dietary components on TL (1, 3–6). The 2 main mechanisms implicated in the association between diet and leukocyte TL are oxidative stress and inflammation (7). Therefore, it is expected that an antioxidant or an anti-inflammatory diet could lessen the rate of telomere shortening, which may delay aging. Indeed, a higher intake of specific antioxidants and anti-inflammatory dietary components such as vitamin C or E, polyphenols, curcumin, or omega-3 (n–3) fatty acids have been associated with longer telomeres.

Can You Spice Up Your Antidepressant? The evidence for curcumin in depression
Psychology Today, December 2016
Curcumin is more interesting than many other alternative-medicine highly-touted phytochemical compounds as an anti-inflammatory because there’s already about a decade of human data for adjunctive and/or remission stability improvement from curcumin in
autoimmune diseases such as ulcerative colitis. These studies show some benefit and very few side effects at fairly high doses, double or quadruple those used in the depression studies.

The 7 Incredible Health Benefits of Turmeric
ClapWay.com December 2016
With curcumin’s anti-inflammatory properties, turmeric helps stimulate the body’s natural defense mechanisms, which helps the body to heal and preserve itself naturally. The reputation of turmeric for reducing inflammation actually owes to its active ingredient, curcumin. You also may want to start adding ginger to your pain or inflammation tonics for an even more potent effect. Turmeric can assist in the lowering of cholesterol and also prevent the blockage of arteries that can cause heart attacks and strokes. Curcumin can lower cholesterol levels and also inhibit the oxidation of LDL.

6 Reasons to Always Have Turmeric
VozdeguanaCaste.com December 2016
Curcumin has substances that regenerate and protect the liver. A study by the Medical Association of Thailand links this substance to an effective fight against cancer and an improvement of the organ’s fibrous tissue, as well as to the regeneration of affected hepatic cells. Curcumin also is linked to improvements in gallbladder health.  Curcumin is important nourishment against cancer, as it blocks the development of cells and promotes apoptosis (cell self-destruction), differentiating between carcinogenic cells and normal ones. At the same time, it can halt metastasis (spreading of cancer from one organ to another), according to the findings of a 2011 study by the University of Texas Anderson Cancer Center.  According to the Arthritis Foundation, curcumin eases pain, swelling and stiffness associated with rheumatoid arthritis and osteoarthritis. Curcumin’s antioxidant and anti-inflammatory properties can be used as a complementary tool in the treatment of depression, according to a 2014 study published in the Journal of Affective Disorders.  According to the 2014 edition of the magazine BioMed Research International, several studies have shown that curcumin acts against a range of bacteria and microbes. Consuming it has antiviral, antimicrobial and antifungal effects.

Boost brain performance, reduce cognitive decline
BonnerCountyDailyBee.com December 2016
Curcumin, extracted from the spice turmeric, helps remove toxic waste, disrupt formation of plaques, and has anti-inflammatory properties. It tweaks a major control point that regulates many other activities in brain cells by encouraging them to operate in a balanced matter.

 The best supplements to take for over-60s
Startsat60.com December 2016
Due to its ability to block inflammation, curcumin could help stop disease-causing inflammation found in cancer, diabetes, cardiovascular disease, cystic fibrosis, and depression. Turmeric can also treat rheumatoid arthritis. Dr Greg Cole, associate director of UCLA’s Mary S Easton, spent years studying curcumin as a treatment for brain diseases specifically Alzheimer’s disease and dementia. In his long time studying curcumin as a cure, he has observed that it reduces the build-up of this disease in the brain.

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study
Journal of Affective Disorders, November 2016
Active drug treatments comprising differing doses of curcumin and combined curcumin/saffron were effective in reducing depressive and anxiolytic symptoms in people with major depressive disorder.

Study Says This SPICE Might Be As Effective For Depression As Prozac
inquisitr.com November 2016
This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders.

Healthy Living: Curcumin To Fight Cancer?
9and10news.com November 2016
A previous study found taking curcumin while undergoing chemotherapy increased the effectiveness of the treatment. If you are shopping for supplements and want the full benefit of curcumin, buy curcumin capsules, not turmeric. Remember turmeric is the spice, curcumin is the medicine.

The mood and cognitive effects of curcumin from turmeric
The Fiji Times, November 2016
Curcumin is the component of turmeric (Curcuma longa) that gives the spice — and many curries — its bright yellow colour. It is one of more than 5000 flavonoids, a group of plant-based compounds thought to contribute to the health benefits of fruit and vegetables. While any meaningful clinical effects are far from proven, at least the trials have a scientific foundation. Curcumin has significant anti-inflammatory properties that are said to rival those found in ibuprofen, the active ingredient in Nurofen. Unlike over-the-counter drugs though, turmeric has no known toxic effects on the body. Curcumin's powerful antioxidant advantages have been shown to protect healthy cells in research, particularly those found in the colon, from cancer-causing agents. It aids the body in destroying mutated cancer cells before they have a chance to spread to other areas.

5 Top Natural Cancer-Fighting Supplements
NewsMax Health, November 2016
Curcumin. Turmeric is a spice used to flavor traditional Indian dishes, and its active component is curcumin, a potent anti-inflammatory that gives turmeric its bright yellow color. Studies show it can fight even the deadliest cancer — pancreatic, which has a 5-year survival rate of only 7 percent. A Phase II clinical trial at MD Anderson Center gave 25 pancreatic cancer patients 8 grams of turmeric a day for two months. Tumor growth stopped in two patients, one for eight months and another for two-and-a-half years. Another patient's tumor temporarily regressed by 73 percent. The only two drugs approved by the FDA are effective in no more than 10 percent of patients, and turmeric's effectiveness was similar with no side effects. In another study, turmeric reduced tumor growth in mice with pancreatic cancer by 43 percent. When combined with fish oil, which helps the body absorb turmeric, tumor growth was reduced by 70 percent. A study at the University of Missouri found that curcumin decreased the incidence of progestin-accelerated breast tumors in animals. It also delayed onset of the disease and reduced the incidence of multiple tumors.

Let turmeric color your life
DELANO News, November 2016
Curcumin is also protective of the liver, it lowers blood fat levels and it reduces weight gain. In some cases it is effective against hay fever and it can help treat inflammatory skin conditions, too. Of course, as it is a bitter, it also stimulates digestion and keeps the digestive muscular system working smoothly.

The Healing Properties Of The Eastern Diet Explained
Luxury London, November 2016
Curcumin in turmeric works to fight free radicals and aid with blood flow and circulation.

Turmeric and Exercise: a Magic Combination for Heart Health
Care2.com November 2016
The magnitude of the improvement achieved by curcumin treatment was comparable to that obtained with exercise. Therefore, regular ingestion of curcumin could be a preventive measure against cardiovascular disease. Furthermore, results suggest that curcumin may be a potential alternative treatment for patients who are unable to exercise.

The 7 Foods That Relieve Joint Pain
The Huffington Post,November 2016
The health benefits of turmeric—the yellow spice that flavors curries—are vast. Curcumin, a compound found in turmeric, has been shown to help suppress cancer, reduce blood pressure, and have a positive impact on inflammation, just to name a few. One University of Arizona study found that the curcumin can help protect against joint deterioration and inflammation caused by rheumatoid arthritis. Another study researched how well ibuprofen eased pain over curcumin, and found that the benefits were about the same for both.

Curcumin modulates the effect of histone modification
International Journal of Chronic Obstructive Pulmonary Disease, November 2016
Curcumin may suppress chemokines and restore corticosteroid resistance in COPD through modulating HDAC2 expression and its effect on histone modification.

9 amazing health benefits of turmeric curcumin
BT.com October 2016
1. Kill cancer: The curcumin in turmeric has been found capable of killing cancer cells and able to slow the growth of tumours. 2. Soothe arthritis: “In a 2013 study, turmeric was shown to significantly reduce the severity of chronic joint inflammation in those with rheumatoid arthritis,” notes Abby Sauer, registered dietitian at Abbott. “In addition, turmeric has been considered as a promising treatment to reduce osteoarthritis pain due to its anti-inflammatory benefits.” 3. Fight diabetes: “When taken daily, turmeric’s most prominent component, curcumin, has been shown to delay the development of type 2 diabetes in patients who were at high risk of developing the disease,” says Sauer. 4. Deal with depression: Along with certified medical and psychological help, “turmeric has been shown to reduce depressive symptoms, and boost patient’s treatment success,” explains Sauer. 5. Avoid heart attacks: Those at risk of heart attack tent to suffer plaque build-up, known as atherosclerosis, in their arteries. “Turmeric has been found in animal studies to prevent blood clots from building up along artery walls, which could give patients with atherosclerosis a significant chance to reduce their risk of a heart attack,” says Sauer. 6. Tackle gut conditions: In patients with ulcerative colitis in remission, says Sauer, “turmeric was found to noticeably assist conventional medical treatment to keep patients in remission”. 7. Limit reflux: “Turmeric’s antioxidant and anti-inflammatory properties have been shown to reduce inflammation in the oesophagus,” which can cut the effects of reflux after eating, says Sauer. 8. Lower your cholesterol: That good old curcumin in turmeric has also been found to help balance out cholesterol levels. 9. Pain relief: Traditionally turmeric has been used as a natural painkiller, and have even been shown to mimic the effects of steroids.

Turmeric Beats Depression, Active Ingredient Curcumin Works As Well As Prozac
inquisitr.com October 2016
Multiple studies have now shown that the active ingredient in turmeric, curcumin, is an effective treatment against clinical depression and is as effective in treating serious depression as Prozac — perhaps even more so. Turmeric, a member of the ginger family, is probably best known for its culinary uses. It is frequently used in Indian dishes and as a natural food coloring because of its distinctive yellow color. Turmeric has been also used for thousands of years in treating a multitude of health conditions. Green Med Info, which compiles research studies on natural health products, lists over 2,000 research studies that proved benefits of turmeric ranging from treating arthritis to helping with weight loss to relieving symptoms of Irritable Bowel Syndrome, just to name a few. Hundreds of other health benefits of turmeric have also been reported.

If You Are Prone To Allergy, Make Sure You Regularly Eat These 10 Superfoods
Boldsky.com October 2016
The curcumin content in turmeric makes it a strong anti-allergic agent. Curcumin is an antioxidant and anti-inflammatory compound that equips our immune system to fight allergies.

Popular ingredient in Indian food may help fight cancer
WNDU.com October 2016
Taking curcumin while undergoing chemotherapy increased the effectiveness of the treatment. If you're shopping for supplements and want the full benefit of curcumin, buy curcumin capsules, not turmeric.

Spices with benefits
Food in Canada, October 2016
The active ingredient of turmeric, called curcumin, is a type of polyphenol. Among other things, curcumin has been shown to help prevent depression in mice, and scientists are studying its impact on treating Alzheimer’s disease. Studies on rats from a few years ago showed that turmeric could help prevent and maybe even reverse liver damage, and there are ongoing studies looking into its impact on treating or preventing cancer, particularly colon cancer. It’s also been studied as an anti-inflammatory, a treatment for arthritis, a preventative measure for people at risk of developing diabetes, and more.

Curcumin Can Protect Your Brain from Dementia and Alzheimer’s Disease
MensFitness.com October 2016
Curcumin—a bright orangeish chemical compound that’s found in turmeric and is integral to most curries and many other Asian foods (not to mention good old American mustard!) has already been shown to be a powerful anti-inflammatory. Now evidence is growing that it also stymies the destruction of brain neurons—meaning it may combat dementia and even Alzheimer’s disease. Researchers in a year long study at Australia’s Edith Cowan University gave cognition tests to 96 middle-aged and elderly subjects, then sent half of them home with concentrated curcumin pills, and the other half with a placebo. When all were retested just six months later, those who’d been taking the placebo showed a decline in verbal and memory skills—but the ones taking curcumin showed no such decline.

How Turmeric Wards Off Infectious Diseases
AllAfrica.com October 2016
Several medical properties have been attributed to Curcumin (Curcuma longa). The rhizome is known to possess therapeutic activities and has been used by medical practitioners as an anti-diabetic, hypo-lipidemic, anti-inflammatory, anti-diarrhoeal, hepato-protective, anti-asthmatic and anti-cancerous drug. Curcuma longa is widely used in cosmetology.

Curcumin fights ovarian cancer
ScienceDirect.com October 2016
Curcumin increases cytosolic Ca2+ concentration through inhibition of SERCA activity, causing apoptosis in ovarian cancer cells.

The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis
US National Library of Medicine, October 2016
Osteoarthritis is a significant medical condition for the aging population worldwide. Curcumin, a NF-κB suppressor, demonstrates potential as a treatment agent for osteoarthritis, a disease with an underlying inflammatory cause. Its efficacy in reducing pain, physical function, and quality of life among osteoarthritic patients has been demonstrated in many clinical trials. The effects of curcumin on osteoarthritis can be attributed to its ability to prevent apoptosis of chondrocytes due to inflammation predominantly, and oxidative stress to a lesser extent. Randomized controlled trials involving larger sample size and longer treatment, proper selection of patients, and improved formulation could better justify the use of curcumin as an alternative treatment for osteoarthritis.

Curcumin for Anti-Cancer and Other Profound Benefits
Natural Products Insider, October 2016
Curcumin is a naturally occurring chemical compound that is found in the spice turmeric. Several studies suggest curcumin might ease symptoms of osteoarthritis and rheumatoid arthritis, including pain and inflammation. Moreover, these potent anti-inflammatory benefits seem to be quite protective against some forms of cancer progression. However, curcumin has additional anti-cancer effects that are independent of its anti-inflammatory effects and thus is a heavily researched molecule for both cancer prevention and treatment. Studies have shown curcumin helps prevent several forms of cancer including breast, lung, stomach, liver and colon. It stops development of cancer by interfering with the cellular signaling aspects of this chronic disease. Interestingly, my research unveiled curcumin has "smart kill" properties that actually work to inhibit the growth of tumors and the spread of cancer in fundamental ways at the cellular level. It has the laboratory-proven capability to inhibit a particular cancer-promoting enzyme (COX-2), impede blood supply to cancer cells, induce tumor-suppressing genes, stop metastasis, kill lymphoma cells and prevent the regrowth of cancer stem cells. The ability to target cancer stem cells is one of curcumin’s most powerful anti-cancer properties. In fact, according to GreenMedInfo.com, a recent study describes the wide range of molecular mechanisms presently identified by which curcumin attacks cancer stem cells (CSCs), which are the minority subpopulation of self-renewing cells, within a tumor colony. These stem cells alone are capable of producing all the other cells within a tumor, making them the most lethal, tumoriogenic of all cells within most, if not all, cancers. Because CSCs are resistant to chemotherapy, radiation, and may even be provoked toward increased invasiveness through surgery, they are widely believed to be responsible for tumor recurrence and the failure of conventional cancer treatments. These are compelling findings, indeed. Furthermore, some of the most fascinating curcumin research also dovetails with what I experience so much of: muscle soreness. A new, double-blind, randomized-controlled study published in the European Journal of Applied Physiology in March 2015 indicated curcumin can help reduce pain associated with delayed onset muscle soreness (DOMS) and aid muscle recovery in physically active people.

This Is Why Turmeric Should Be In Your Kitchen Cupboard
Grazia Daily, October 2016
A new study published in the journal Phytotherapy Research has confirmed that the chemical curcumin found in turmeric is safe and effective in treating depression. Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumors.

Curcumin prevents muscle damage
Journal of Inflammation Research, September 2016
Exercise (Ex) increases reactive oxygen species and impairs antioxidant defense systems. Recent data suggest that curcumin (CW) possesses peroxisome proliferator-activated receptor gamma activity and anti-inflammatory properties. Therefore, this study was designed to investigate the effects of CW supplementation on Ex performance, endurance, and changes in serum and muscle proteins in rats after exhaustive Ex.

Curcumin and silymarin form promising pair for colon cancer treatment
Yahoo.com, September 2016
The Journal of Cancer has published a study revealing the therapeutic effects of two antioxidant compounds when combined to fight colon cancer. Curcumin is the active ingredient in turmeric, already known for its anti-inflammatory properties, whereas silymarin, a component of milk thistle, has been used to treat liver disease. In laboratory tests, researchers from Saint-Louis University in the USA found that colon cancer cells stopped multiplying and spreading, and that cell death increased when exposed to the two natural compounds.

Curcumin helps lung cancer
Foodconsumer.org September 2016
The scientists found curcumin supplementation down-regulates the expression of inflammation biomarkers and promotes apoptosis in cancer cells.

Colon Cancer Treatment: Turmeric Compound ‘Curcumin’ Highly Effective, New Study Finds
Science World Report, August 2016
A new study has found that curcumin, a compound present in spice turmeric, has the potential to treat and prevent colon cancer.

To add some spice
The Daily Star, August 2016
Curcumin, the active component of turmeric, is an object of research owing to its properties that have the potential to turn off certain genes that cause scarring and enlargement of the heart. Regular intake may help reduce low-density lipoprotein (LDL) or bad cholesterol and high blood pressure, increase blood circulation and prevent blood clotting, helping to prevent heart attack. Curcumin also kills cancer cells and reduces the size of tumours. Turmeric aids in treating arthritis, heartburn, stomach pain, diarrhoea, intestinal gas, stomach bloating, and loss of appetite. Turmeric is also used as a topical treatment for issues like skin inflammation, infected wounds, and ringworm.

Naturally Detox
PopSugar, August 2016
This super spice contains high levels of a compound called curcumin, which has powerful antioxidant and anti-inflammatory actions. According to a study in the Journal of the Medical Association of Thailand, curcumin enhances liver health and offers protection from liver cancer and disease. This powerful antioxidant can also repair and regenerate damaged liver cells. It's basically magic in a spice.

5 reasons why you must include ‘haldi’ in your diet
Tribune, August 2016
Curcumin supplements showed that root can potentially prevent heart attacks. This particular study was conducted on a group of patients that had previously undergone bypass procedures. It was proved that 30% of the individuals from the placebo group experienced heart attacks during their hospital stay, compared to only 12% of the ones from the supplement group. Keep in mind that this does not mean you start swallowing large spoonfuls of the spice to avail all these health benefits. The powdered spice in your kitchen contains less than 10% of Curcumin. Consult your physician to learn about FDA recommended supplements for best results.

Suffering from colon cancer? Turmeric may be the cure
Science Daily, August 2016
A preliminary cell study finds combining curcumin, the active ingredient in spicy curry dishes, and silymarin, a component of milk thistle, inhibited the spread of colon cancer cells and increased cancer cell death

Herbal Cure: Turmeric Can Help Fight Colon Cancer
Health Newsline, August 2016
For the lab test, researchers used three different human colon cancer cell lines and treated them with varying doses of curcumin, silymarin, and a combo of curcumin and silymarin. Cell proliferation (increase in the number of cells) and apoptosis (a process of programmed cell death) were assessed after treating the cells with the compounds. The research team observed a significant difference between single compound-treated cells and cells treated with a combo of both compounds. They found cells treated with either phytochemical alone had low levels of apoptosis, while treating the cells first with curcumin and then with silymarin resulted in an increased cell death, thus was more effective in fighting cancer. “The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death,” said study author Dr. Uthayashanker Ezekiel, from Saint Louis University.

A recent research has revealed that the turmeric has a compound that treat colon cancer.
News World India, August 2016
The study found that combination of two plant compounds- curcumin and silymarin – holds promise in treating colon cancer as both have medicinal properties. Curcumin is the active ingredient in the spice turmeric while silymarin is a component of milk thistle, which has been used to treat liver disease. Treating the cells initially with curcumin, then with silymarin was more effective in fighting cancer than treating the cells with either phytochemical alone.

Up-and-Coming Kitchen Spices
Whole Foods Magazine, August 2016
When using turmeric as a culinary spice, choose dried turmeric rather than curry powder for the highest concentration of curcumin (12). Curcumin, the pigment that gives turmeric its yellow-orange color, is well known for its powerful antioxidant and anti-inflammatory properties (12). Studies suggest curcumin may lower the levels of enzymes that cause inflammation and prevent platelets from clumping. In one study, turmeric worked as well as ibuprofen for reducing osteoarthritis pain.

Where to turn for relief from joint pain, arthritis
The Dickenson Press, August 2016
Favorite natural supplements that provide unique synergistic benefits in the management of osteoarthritis, rheumatoid arthritis, and even joint support for the hardcore and recreational athletes. The first ingredient is curcumin. I have called curcumin my desert island nutrient due to its multiple benefits of detoxification, digestive, cellular, mood, cognitive, antioxidant and musculoskeletal support. Besides the effectiveness of curcumin, what I really love is that it counteracts negative side effects of both NSAID's and acetaminophen. Curcumin has been used to actually treat ulcers, as NSAID's are known to cause ulcers. Where acetaminophen can lead to liver damage, curcumin has shown to be supportive of both liver and kidney function. As far as effectiveness goes, curcumin has shown to be more effective than prescription diclofenac for reducing pain and enhancing mobility. In another study, a combination of curcumin, and my next favorite ingredient, boswellia, performed better than the prescription anti-inflammatory celecoxib (Celebrex).

Psychopharmacology and Neuropsychopharmacology Research
News-medical.net August 2016
The study was funded by Verdure Sciences and found that in individuals who regularly consumed curcumin, memory and attention capabilities improved. Curcumin also seemed to inspire calmness, contentedness, and improved energy levels in observed subjects.

Can Turmeric Cure Our National Inflammation?
New York Magazine, August 2016
Curcumin, the chemical turmeric produces, is a powerful anti-inflammatory. And inflammation is a hot topic (sorry again) in wellness circles. “There’s this idea where if you have free-floating inflammation you are much more vulnerable to all sorts of things from heart disease to skin aging,” says Jean Godfrey June, the beauty director of Goop. Until recently, she points out, “The culture in skin care, and in medicine I think, has been to attack and fight. But now people are realizing that harsh treatment makes inflammation worse, and that soothing your system is more important.” This, if anything, explains the popularity of turmeric in America in 2016.

Examining Turmeric's Role in Fighting Cancer
Curetoday.com August 2016
Curcumin has demonstrated incredible anticancer benefits. In countries where people eat turmeric daily, research has shown that there are lower rates of certain types of cancer. Ingesting levels of about 100 to 200 mg a day over long periods of time seem to work best in most cases. In an article by Cancer Research UK it was said that studies on cancer cells have shown “…that curcumin does have anticancer effects. It seems to be able to kill cancer cells and prevent more from growing. It has the best effects on breast cancer, bowel cancer, stomach cancer and skin cancer cells.” Curcumin has been extensively researched for many years and although promising results have been obtained from laboratory trials, it is still not seen as a widely prescribed cancer therapy.

The many uses for turmeric
The Spectrum, August 2016
Turmeric is antioxidant,  anticarcinogenic, antimicrobial, antibiotic, antimutagenic, and anti-inflammatory. The chemical in turmeric that reduces inflammation and has many other benefits is called curcumin.

Bodily Tissues That Can Be Regenerated Through Nutrition
Collective-Evolution.com August 2016
Curcumin supplements can help treat crushed nerve injuries, and pave the way for the regeneration of damaged tissues. “Curcumin is capable of promoting nerve regeneration after nerve injuries, highlighting the therapeutic values of curcumin as a neuroprotective drug for peripheral nerve repair applications.”

For the love of turmeric
Fosters.com August 2016
Curcumin, extract of turmeric, breaks down amyloid-beta plaques which contribute to the effects of Alzheimer's disease. India has a low incidence of the disease which could be attributed to their use of turmeric.

Study says Turmeric key to treating various types of cancer
The Standard, August 2016
Turmeric contains curcuminoids, which are the main component found to be effective in cancer treatment. “Curcumin, the principal curcuminoid of turmeric, has been intensely studied as a cancer protective agent. Its potential has been tapped in head and neck cancers, breast, lung, gastro-intestinal cancer, ovarian cancer, melanoma, neurological cancers, sarcoma, leukemias and lymphoma,” said the study. “Curcumin suppresses all three stages of carcinogenesis: initiation, promotion and progression. It also has a role in neutralizing substances and conditions which lead to cancer.” “By inhibiting the enzyme Topoisomerases, which is required for multiplication of cancer cells, it is able to arrest the growth of these cells,” said Sharma. With time, cancers cells tend to become resistant to chemotherapy and radiotherapy, Sharma observed. Curcumin, on the other hand, when consumed in therapeutic doses, targets several cancer pathways and sensitizes the cancer cells to chemotherapy drugs by increasing the pace of death of the cancer cells, she said. “Studies in advanced breast cancer have also shown that curcumin increases the effect of chemotherapy and prevents the spread of cancer cells to the lung,” she said. “In lung carcinoma, when curcumin is added to the chemotherapeutic drug, it increases the effectiveness of the drug by promoting cell death of cancer cells. The efficacy of it has also been seen in the brain tumors where it sensitises the tumor cells to the cancer drugs,” said Sharma. The study shows curcumin enhanced the effect of radiotherapy by inhibiting tumor regrowth per se, and also by suppressing new vessel formation. Being a powerful antioxidant it scavenges all the harmful free radicals induced by radiation exposure of the cells, thereby reducing the side effects of radiotherapy. According to Delhi-based Nutritionist Anshul Jaibharat, “To be brief, turmeric can termed as an Indian wonder spice. It’s anti-inflammatory and hence helps in people suffering from arthritis. It works as an antiseptic and is warm in nature so it’s good for people having cold and cough during changes in weather. The raw form when grinded has the best nutritional value even more than the processed and packaged one. The compound curcumin in turmeric has shown numerous benefits to human body as per both Ayurveda and Modern science.” – from NDTV

How Curcumin Has Helped Me Control My Pain
ProHealth July 2016
Curcumin–an anti-inflammatory compound extracted from the medicinal herb turmeric. A search on PubMed alone yields 130 studies on the topic of curcumin and pain. Curcumin assists the body in mediating several inflammatory processes. I stumbled upon the benefits of curcumin in 2010, as facial muscle spasms, neck, and low back pain kept me in constant agony. At that time, I was diagnosed with fibromyalgia. Determined to find some help, I dove into the well-worn pages of one of my favorite books, Prescription for Natural Cures, by James Balch, M.D. and Mark Stengler, N.D. In this book, the clinicians refer to curcumin as an outstanding anti-inflammatory herb.

9 Reasons Turmeric Is The Top Culinary Medicine
LongevityLive.com July 2016
Whether we are healing from an injury or an autoimmune disease, inflammation is a common health challenge. Nutritionists, functional medicine GP’s and physiotherapists commonly use curcumin for it’s anti-inflammatory qualities.

The Superfood Spice
Thrillist.com July 2016
Besides being used for thousands of years in Chinese and Ayurvedic medicine, turmeric's many health benefits have also been backed up by modern science.

This Spice Can Keep Bad Thoughts Away
Delish.com July 2016
Published in the journal Neuropsychopharmacology, the study says that turmeric—which is often used in curries and mustard—can impair your ability to recall fear-related memories. This is due to an abundance of curcumin, a chemical responsible for turmeric's anti-inflammatory properties and potential anti-depressant uses. So far the study has only tested rats but the results imply that curcumin could be applied to help fight disorders like PTSD.

Turmeric : Get To Know the 'Curcumin' Loaded Spice That Can Block Off Bad Memories
ParentHerald.com July 2016
In a study lead by Professor Glenne Schafe, it was noted that the rats who consumed curcumin, an element present in turmeric, are more likely to forget bad memories. The rats who fed on curcumin are not fully functional when it comes to encoding "fear memories." "We showed that rats freely fed a diet enriched with curcumin [found in turmeric] have impaired encoding of fear memories," lead of the study Professor Glenne Schafe said. "We also showed that rats with a pre-existing fear memory can lose that memory when it is recalled while they are eating a curcumin-enriched diet." The researchers came to conclusion that rats who were fed curcumin were able to hide negative memories for a long period of time. Repressing memories make it hard for them to go through painful experiences as curcumin repels the negative experiences that affects the rats. Curcumin, which is preset in turmeric is said to have a positive soothing effect which acts as an anti-inflammatory, it is also known to be chemopreventive, and is said to have anti-depressant properties.

Spice up
TheStar.com July 2016
Turmeric is a spice derived from the roots of the Curcumin longa plant, which is native to Southeast Asia. The most active and best-studied curcuminoid of all is curcumin, which is often extracted from turmeric and sold as a supplement. Turmeric has anti-inflammatory functions that are similar to omega-3 fatty acids, the key type of fat found in fatty fish, like salmon. That could translate to potential benefits for heart and joint health, and indeed, several studies suggest curcuminoids could help reduce symptoms of osteoarthritis, the painful condition caused by the breakdown of the cartilage cushion between joints, to an extent similar to the anti-inflammatory ibuprofen, and with fewer digestive side-effects. Other studies suggest curcumin could help manage digestive disorders. In one study, more than half of patients with ulcerative colitis found themselves in remission after taking 3,000 mg of curcumin per day for four weeks compared with none of the patients given a placebo. There are also suggestions curcumin could help prevent the onset of diabetes, control blood pressure, and even minimize muscle soreness after exercise, though not all studies have produced positive results. A number of studies on animals and human cells also suggest curcumin could have anti-cancer effects, and at least one study demonstrated that taking two or four grams of curcumin per day for a month was associated with slower development of pre-cancerous changes in the colon of in smokers.

Turmeric Is Effective In Treating Various Types Of Cancer: Study
NDTV.com July 2016
Curcumin, the principal curcuminoid of turmeric, has been intensely studied as a cancer protective agent. Its potential has been tapped in head and neck cancers, breast, lung, gastro-intestinal cancer, ovarian cancer, melanoma, neurological cancers, sarcoma, leukemias and lymphoma," said the study. Tapaswini Sharma, Senior Consultant (Surgical Oncology) at B.L. Kapoor Memorial Hospital, said: "Curcumin suppresses all three stages of carcinogenesis: initiation, promotion and progression. It also has a role in neutralising substances and conditions which lead to cancer." "By inhibiting the enzyme Topoisomerases, which is required for multiplication of cancer cells, it is able to arrest the growth of these cells," said Sharma. With time, cancers cells tend to become resistant to chemotherapy and radiotherapy, Sharma observed. Curcumin, on the other hand, when consumed in therapeutic doses, targets several cancer pathways and sensitizes the cancer cells to chemotherapy drugs by increasing the pace of death of the cancer cells, she said. "Studies in advanced breast cancer have also shown that curcumin increases the effect of chemotherapy and prevents the spread of cancer cells to the lung," she said. "In lung carcinoma, when curcumin is added to the chemotherapeutic drug, it increases the effectiveness of the drug by promoting cell death of cancer cells. The efficacy of it has also been seen in the brain tumours where it sensitises the tumour cells to the cancer drugs," said Sharma. According to the study, curcumin enhanced the effect of radiotherapy by inhibiting tumour regrowth per se, and also by suppressing new vessel formation. Being a powerful anti-oxidant it scavenges all the harmful free radicals induced by radiation exposure of the cells, thereby reducing the side effects of radiotherapy.

Turmeric effective in treating various types of cancer
Indian Express, July 2016
Turmeric has nearly 20 molecules with antibiotic property, 14 molecules with cancer preventive potential, 12 with anti-tumour effect, says the study conducted by BL Kapoor Memorial Hospital, New Delhi. “At least 12 molecules in it have anti-cancer effect while 10 of them have anti-oxidant features. Overall, turmeric is known for it’s antibiotic, antiseptic, anti-cancer and anti-oxidant property. It is known to be a good digestive substance,” said the study. According to the study, turmeric contains curcuminoids which are the main component found to be effective in cancer treatment.

What Are the Benefits of Turmeric and Curcumin?
Transcend.org June 2016
Research within the 50 years has shown much of the supposed benefit of turmeric is due to curcumin, the active component. Curcumin, a polyphenol, has displayed activity in antioxidant, anti-redness, anti-harmful organism capacities. Because of this, polyphenols have generated inquiries into their potential to provide support for ailments proven to be therapy resistant, including chronic illnesses.

Curcumin and cognition: a randomised, placebo-controlled, double-blind study
Br J Nutr. June 2016
"a decline in function of the placebo group at 6 months that was not observed in the curcumin treatment group."

Hot Trends in Healthy Eating for 2016
TNTMagazine.com July 2016
Turmeric contains curcumin, a chemical shown to decrease inflammation. In traditional Eastern medicine, turmeric is used to treat a huge range of conditions including bowel irritation, heartburn, depression, and high cholesterol. Inflammation in the body is generally not desirable and there don’t seem to be any downsides to taking turmeric in moderate doses.

Indian spice with huge health benefits
Business Insider, June 2016
Turmeric’s active ingredient, curcumin, has been suggested to treat a suite of dermatological diseases. A study done just last month uncovered treatment in the forms of oral ingestion and topical application showed significant improvement in skin health. Some conditions you can look forward to possibly being relieved if you take a chance on turmeric are acne, psoriasis, alopecia, and facial photoaging. The spice’s ingredients also provide a potent anti-inflammatory effect. This means less swelling and pain after irritation or injury. It has been used to significantly decrease pain and other side effects after acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which are both linked to high cases of mortality and hospital treatment. Other anti-inflammatory benefits of turmeric and curcumin may include relief from arthritis and tendinitis. And here comes the granddaddy of all news: The curcumin in turmeric could help protect your body against cancer.

Beat the flu this winter
Health24.com June 2016
Curcumin: Studies show that a promising new treatment for severe inflammation – which is at the heart of most chronic diseases – is found in curcumin, a natural ingredient in the common spice, turmeric.

Top 10 Anti-cancer Superfoods
HealthAim.com June 2016
The active ingredient found in turmeric called curcumin is a powerful antioxidant. Researchers found that curcumin showed anti-cancer effects at virtually all stages of tumor development.

5 Superfoods You're Probably Not Eating
Alternet.org June 2016
A member of the ginger family whose root is widely used as an ingredient in medicines, turmeric is a superfood that has many health properties. Since ancient times, turmeric has been used to fight inflammation, a power given to it by the compound curcumin, which has been found to inhibit several molecules that play a role in inflammation in human clinical trials. It has also been used to treat a wide number of ailments, including arthritis, heartburn, ulcerative colitis, diarrhea, high cholesterol, headaches, bronchitis, fibromyalgia and depression. Curcumin may also help fight cancer, as its antioxidants may help prevent free radicals from damaging cellular DNA. The fact that its wide-ranging health properties may be used as a potential treatment for a number of afflictions common to older people means that turmeric isn’t just a hipster fad. “Turmeric has potential as an ingredient in supplements and functional food and drink products, particularly within products aimed at the growing senior population,” says Stephanie Mattucci, a global food science analyst at Mintel. A 2012 study backs up her view. Researchers described three patients with Alzheimer’s disease whose behavioral symptoms were “improved remarkably” after consuming 764 milligrams of turmeric for 12 weeks. The researchers concluded that turmeric is "effective and safe" for the treatment of the behavioral and psychological symptoms of dementia in Alzheimer's disease patients. (As a dietary supplement, curcumin extracts are generally preferred, since in its raw state, turmeric has low bioavailability.)

Eating Turmeric In Curry Could Stave Off Dementia, Study Suggests
Huffpost June 2016
The researchers found curcumin has the potential to improve memory function for adults by blocking proteins that destroy neurones in the brain.

Curcumin may help overcome drug-resistant tuberculosis
Science Daily June 2016
New research indicates that curcumin--a substance in turmeric that is best known as one of the main components of curry powder--may help fight drug-resistant tuberculosis. The ability of curcumin to modulate the immune response to Mycobacterium tuberculosis points to a potential new tuberculosis treatment that would be less prone to the development of drug resistance. "Our study has provided basic evidence that curcumin protects against Mycobacterium tuberculosis infection in human cells," said Dr. Xiyuan Bai, lead author of the Respirology study.

Turmeric: Could it help against Alzheimer’s?
Miami Herald, June 2016
Turmeric’s power comes from the polyphenol curcumin found in the stem of the turmeric. It has been used medicinally for more than 3,000 years for ailments as diverse as congestion, bruising and blemishes A review of turmeric and cancer in 2014 concluded that this bright orange spice reduced both the invasiveness and spread of cancer. A human study from this year demonstrated that curcumin supplementation reduced the symptoms of exercise-induced muscle damage. Curcumin is acknowledged as a potent anti-inflammatory and antioxidant. I even came across a research article that described this effect on children with moderate to severe asthma. In the study, 47 children with asthma were given a supplement with curcumin, resveratrol, zinc and selenium and had reduced airway inflammation. And a study just last month in The Journal of Alzheimer’s Disease showed that in rats with Alzheimer’s, curcumin was neuroprotective and inhibited amyloid beta plaque accumulation.

Fight pain with food
Hippocratic Post, June 2016
Turmeric, commonly used in Indian and Thai curry dishes has been found to have anti-inflammatory properties. Curcumin has been found to be the main therapeutic ingredient in the spice. Research has shown that curcumin is effective for aching joint reducing painful swelling. A Thai study found that the spice significantly reduces the pain caused by rheumatoid arthritis, and may be as effective as ibuprofen.

Turmeric/curcumin help skin diseases
Food Consumer, June 2016
Studies suggest that curcumin may be employed to treat dermatologic diseases. The reviewers identified 234 articles through the PubMed and Embase databases and reviewed 18 of them which met inclusion criteria. Some studies investigated the effects of ingested turmeric/curcumin on skin conditions while others looked into the effects of topically applied turmeric/curcumin. Ten studies show that treatment with turmeric/curcumin significantly improved skin diseases, compared with placebo. The skin conditions considered in the studies include "acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo." The reviewers conclude "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health".

Spice up your life with Turmeric
Divine.ca June 2016
1. Cancer Prevention Recent studies show turmeric is a powerful adversary to cancer. Curcumin shows an ability to stop cancer cell growth, boost antioxidant levels and the immune system, and kill cancer cells. 2. Promotes Weight loss and Prevents Type 2 Diabetes Helps promote weight loss by suppressing the activity and number of immune cells in fat tissue. These are the cells that are responsible for an increase in insulin resistance in muscles and the liver, which stores sugars as fats in the body. Turmeric helps balance blood sugar which in turn also prevents development of Type 2 Diabetes in those with a diabetic disposition. 3. Relieves Arthritis Due to it’s anti-inflammatory properties, curcurmin improves symptoms of Rheumatoid Arthritis such as pain, inflammation and stiffness of the muscle. 4. Helps Brain Function Turmeric is extremely healing for the brain and for increasing memory function. Some studies say that curcurmin can help improve overall memory in Alzheimer’s patients because of it is a source high in antioxidants. 5. Prevents Liver Disease Turmeric is great for the liver as it protects it from the damage caused by eating foods that contain high amounts of fat and excessive alcohol consumption.

Turmeric 'blocks the rogue proteins that trigger Alzheimer's disease'
Daily Mail, June 2016
Cultures where curry is a staple have better cognitive function and a lower prevalence of dementia. The yellow spice turmeric was identified as the most probable reason for this - thanks to curcumin. The year long trial published in the British Journal of Nutrition found evidence curcumin blocks rogue proteins called beta amyloid which clumps together and destroys neurons. In the study 96 participants aged between 40 and 90 were given either a daily placebo or 1,500 mg of curcumin for 12 months. In tests of verbal and memory skills, those taking the dummy pill suffered a decline in mental function after just six months that was not observed in those having the curcumin.

2016 Food Trends on Google: The Rise of Functional Foods
ThinkWithGoogle.com June 2016
Turmeric, a spice that's purported to cure everything from cancer to depression, is the breakout star, with searches growing 300% over the last five years.

Turmeric can improve memory and attention in old age, study finds
Science Alert, June 2016
"Curcumin has multiple physiological effects," said researcher Andrew Scholey, from Swinburne University of Technology. "It’s known to reduce inflammation and improve blood flow. It influences multiple processes that nudge brain function in a positive direction." In their initial research, Scholey and his team recruited 60 volunteers aged between 60 and 85, and split them into two groups. One group was given capsules with curcumin, and the other a placebo. The participants then completed a number of computerised mental tasks – such as word and picture recall, simple subtraction, and reaction time tasks - a few hours after taking the supplement, and then after taking it daily for four weeks. Overall, the participants who’d taken the curcumin capsules performed better at the computerised measures of working memory and vigilance. They also reported feeling reduced fatigue as well as improved calmness, contentedness, and stress during testing at the end of the four-week trial. "To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioural effects in humans," the researchers reported in the Journal of Psychopharmacology last year. They also found that there were benefits outside of cognitive improvements. "A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL (low-density lipoprotein) cholesterol and had no effect on haematological safety measures," they reported.

The Spice in Curry Can Improve Memory and Energy Levels
The Science Explorer, May 2016
Past studies have found that older people living in cultures where curry is a staple have better cognitive function and a lower prevalence of dementia, and curcumin was identified as a likely reason for this. A German study found that curcumin can act as part of the brain’s repair kit by stimulating the growth of nerve cells. Another study published in the National Center for Biotechnology found that curcumin can actually encourage the birth of new brain cells, particularly in the hippocampus, a brain region that regulates learning, memory, and mood. In a new study, the Australian researchers recruited 60 volunteers aged between 60 and 85 in order to explore how curcumin has its effects on cognition. The volunteers were split into two groups — one was given capsules with a curcumin formulation, and the other was given a placebo. A few hours after taking the curcumin pill or the placebo, the participants were asked to complete various computerized mental tasks — word and picture recall, simple subtraction, and reaction time tasks. Following this initial experiment, the volunteers took the curcumin supplement daily for four weeks. "To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioural effects in humans," the researchers report in the Journal of Psychopharmacology. At the end of the four-week trial, the participants who had taken the curcumin capsules performed better overall at the memory and vigilance tasks. Plus, they reported feeling a boost of energy levels as well as lower stress and improved calmness and contentedness. "Curcumin has multiple physiological effects," lead researcher Andrew Scholey, director of the University’s Centre for Human Psychopharmacology, said in a press release. "It’s known to reduce inflammation and improve blood flow. It influences multiple processes that nudge brain function in a positive direction."

The Health Benefits Of Turmeric: Better Than Ibuprofen?
Inquisitr.com May 2016
"Turmeric and curcumin, the most active constituent of the spice, have been the subject of thousands of studies. This research shows that curcumin has potent antioxidant and anti-inflammatory properties as well as antiviral, antibacterial, antifungal and immune modulating activities.By helping support the body’s inflammation levels, it is a valuable supplement for those active in sports. The repetitive trauma caused by athletic training causes inflammation and pain that can be controlled with curcumin (turmeric).” Turmeric grows naturally, of course, but is not well absorbed unless taken in supplement form, according to some herbalists. This could come by the way of teas, the roots being incorporated into smoothies, or true curcumin supplementation, which carries enough anti-inflammatory properties to be beneficial. As with many herbs, it is known that the benefits of turmeric are multi-faceted; it also has been shown to decrease the risk of cardiovascular disease and certain types of cancers. According to Shape, Maribeth Evezich, M.S., R.D., a dietitian based in New York City, says that the powerful anti-oxidant does have anti-inflammatory powers.

Curcumin controls MTB infection in model
Healio.com May 2016
Researchers in this study showed an ability to control Mycobacterium tuberculosis in a macrophage infection model using curcumin, according to recent research. “In summary, we have shown that curcumin can augment the ability of human macrophages to control Mycobacterium tuberculosis (MTB) infection,” Xiyuan Bai, PhD, from the Department of Medicine at the Denver Veterans Affairs Medical Center in Denver, Colorado, and colleagues wrote in their study.

Using turmeric for inflammation
Reflector.com May 2016
Curcumin is the major component of turmeric that provides an anti-inflammatory effect. It’s an interesting herbal because it also has antibacterial, antiviral, antifungal, antidiabetic, antifertility and antitumor properties. In an animal study, curcumin was found to give the same anti-inflammatory response as cortisone for acute inflammation. Taking curcumin may be beneficial for those with osteoarthritis, RA, fibromyalgia and ulcerative colitis.

Reasons Why Turmeric Is the Spice Nutritionists Swear By
DivineCarlone.com May 2016
A study shows that curcumin helps your liver metabolize cholesterol at a faster rate and also helps prevent it from accumulating on your arterial walls. A 2013 human trial concluded that curcumin's effectiveness in battling depression is, in fact, similar to that of prescription anti-depressants. By increasing the release of dopamine and serotonin—otherwise known as "feel good" neurotransmitters—concentrated doses of curcumin can help battle depression naturally.

Amber Wonder: The power of turmeric
On Manorama, May 2016
Studies around the world have found that curcumin has anti-arthritic, anti-cancer, anti-viral and anti-infl ammatory properties. “It is listed in superfoods because it is proven to be the healthiest food and has been a part of Asian medicine for centuries,” she says. “It acts on the biochemical processes in the body. Apart from having anti-cancer and anti-arthritic properties, curcumin is also said to promote fat loss and prevent cellular damage caused by the pesticides in food. “Curcumin is a powerhouse of antioxidants, hence it is labelled as a superfood. Consuming it reduces the risk of disease and prolongs life. It is also used in the treatment of Alzheimer’s disease and to improve brain function. It is used as an anti-depressant, too,” she says.

Chemical in turmeric 'stimulates the immune system to fight drug-resistant strain'
Mail Online, April 2016
By stimulating white blood cells - a key part of the immune system - curcumin was able to successfully remove Mycobacterium tuberculosis from infected cells. ‘Our study has provided basic evidence that curcumin protects against Mycobacterium tuberculosis infection in human cells. ‘The protective role of curcumin to fight drug-resistant tuberculosis still needs confirmation, but if validated, curcumin may become a novel treatment to modulate the host immune response to overcome drug-resistant tuberculosis.’

The Health Benefits of Turmeric
Shape, April 2016
Turmeric and curcumin, the most active constituent of the spice, have been the subject of thousands of studies," says Maribeth Evezich, M.S., R.D., a dietitian based in New York City. "This research shows that curcumin has potent antioxidant and anti-inflammatory properties as well as antiviral, antibacterial, antifungal and immune modulating activities." You could benefit from up to a teaspoon a day. Curcumin may also have artery-clearing effects. In one study from Taiwan, people who consumed curcumin extracts daily significantly reduced their levels of bad cholesterol (LDL) in just 12 weeks.

Why turmeric is being touted as ‘nature’s wonder drug’
JWeekly.com April 2016
The principal element in turmeric’s healing power is curcumin, a chemical compound that is gaining popularity (especially in dietary supplements and cosmetics) for its reported antioxidant and antiseptic qualities. People feel that it is an invaluable tool for staving off the signs and symptoms of aging. Curcumin also has great anti-inflammation properties and has been found to be highly effective in helping people manage pain and swelling. It’s used by those suffering from arthritis and joint pain, with some saying it’s even more powerful and effective than over-the-counter pain medications. Root and powder forms of turmeric, a relative of ginger Root and powder forms of turmeric, a relative of ginger Curcumin also has been found to protect the brain against diseases such as Alzheimer’s and Parkinson’s, and assist the body in managing heart disease. Even more, preliminary studies have found that curcumin can inhibit cancer and tumor cell growth.

Turmeric: The wonder spice?
Xpose.ie April 2016
Scientists found that by stimulating human immune cells called macrophages, curcumin was able to successfully remove mycobacterium tuberculosis, the bacteria that causes tuberculosis, from experimentally infected cells in culture. In Asia, turmeric, which comes from the root of the Curcuma longa plant, is used as anti-inflammatory agent to treat a wide variety of conditions, including flatulence, jaundice, menstrual difficulties, toothache, bruises, chest pain and colic.

Curcumin can kill the bacteria that cause drug-resistant TB
The Sun, April 2016
Turmeric is popular in Asia for treating a variety of health conditions – as well as having anti-inflammatory and antioxidant effects. Curcumin is a potent inducer of a mechanism used by human immune cells to kill bacteria. In the current study, researchers tried to determine the effects of curcumin on Mycobacterium TB and found that by stimulating white blood cells - a key part of the immune system - curcumin was able to successfully remove Mycobacterium tuberculosis from infected cells.

Curcumin protects against myocardial infarction-induced cardiac fibrosis
Drug Design, Development and Therapy, April 2016
Curcumin attenuated cardiac fibrosis following MI by regulating collagen deposition, ECM degradation, and CFs’ proliferation and migration. The protective effects of curcumin were attributed to SIRT1 activation. The present study provides new insights into the mechanism of the anti-fibrotic effects of curcumin in the heart. Therefore, curcumin could be tested as an auxiliary therapeutic agent, along with classic treatments, to improve the prognosis in patients with myocardial fibrosis after MI.

Curcumin May Defeat Drug-Resistant Tuberculosis
Medical Daily, April 2016
Curcumin is a substance found in turmeric, a root that’s in the ginger family and originally found in India. Curcumin is turmeric’s most active ingredient and offers anti-inflammatory and antioxidant properties. For centuries, turmeric has been used in both food and traditional medicine; it’s typically boiled down, baked, and ground into a yellow powder. Curcumin gives turmeric its yellow coloring, and as a separate entity from turmeric is often used as an herbal supplement, or added to cosmetics, spices, or food coloring. For thousands of years, turmeric has been used to treat arthritis, stomach problems, and other health issues in traditional medicine and spiritual rituals — more as an herbal supplement than anything else, of course. In 2014, curcumin was shown to reduce post-traumatic stress disorder (PTSD) symptoms, and another study found that curcumin also held potential to shrink cancer tumors or slow their growth. All in all, curcumin has been studied robustly over the years, but most of its health benefits have been played out in laboratory dishes and have yet to be transferred to animal or human trials.

The Health Benefits Of Curry Powder
Huffington Post, April 2016
The journal "Food and Chemical Toxicology" published a study that found that turmeric's active compound, curcumin prevented spikes in blood sugar and improved insulin sensitivity. They concluded that the benefits of turmeric might be due in part to anti-inflammatory effects.

Turmeric Spice Could Fight Drug-Resistant Strains of Tuberculosis
Headlines and Global News, April 2016
The researchers tested out the effects of curcumin in the laboratory setting and found that after stimulating macrophages, which are cells from the body's immune system, the substance was able to remove Mycobacterium tuberculosis, the bacterium that causes TB, through a process that involved preventing the activation of nuclear factor-kappa B. This process removed the bacterium from the cells that were infected during the experiment.

An addition to efficacy of turmeric, helps fight drug-resistant TB
Zee News, April 2016
The study has further revealed that curcumin, which is a substance in Turmeric can successfully remove Mycobacterium tuberculosis, which happens to be the causative bacterium of tuberculosis.

Turmeric may help overcome drug-resistant TB
The Times of India, April 2016
Curcumin--a substance in turmeric--may help fight drug-resistant tuberculosis. Turmeric is commonly used in Indian food and is considered to have anti-inflammatory, antioxidant, and even anticancer properties.

Turmeric May Help Fight Tuberculosis
NewsMax Health, April 2016
The ability of curcumin to modulate the immune response to Mycobacterium tuberculosis points to a potential new tuberculosis treatment that would be less prone to the development of drug resistance. Read more: Common Spice May Aid in Fight Against TB

Turmeric can help combat tuberculosis
LiveMint.com April 2016
According to a US study, turmeric contains a substance called curcumin which can help fight tuberculosis. Researchers from University of Nebraska believe curcumin, which is also responsible for the yellow orange colour of turmeric, by stimulating immune cells called macrophages, can successfully kill the bacteria (mycobacterium tuberculosis) which causes tuberculosis. Turmeric is known for its anti-inflammatory, antioxidant, and anti-cancer properties and is used for its medicinal properties in several Asian countries. The study was published in the journal Respirology here.

Turmeric Extract May Be Your Best Bet For Healing Knee Osteoarthritis
Collective Evolution, April 2016
Curcuminoid extract of turmeric reduced inflammation in patients suffering from knee osteoarthritis.

Tumeric Benefits: Turmeric Can Do Wonders In Your Heart and Body
Parent Herald, April 2016
The main ingredient of turmeric is the curcumin and its yellow color gives its curry spice. Turmeric can help in maintaining the heart health. It actually reduces the plaque build-up that can lead to the blood clot that causes stroke or heart attack. It also lessens the cholesterol oxidation by reducing the LDL or bad cholesterol by 56 percent and the serum triglyceride levels by 27 percent. In addition, tumeric also lowers the total cholesterol by 33.8 percent. Turmeric also has an anti-inflammatory and antioxidant properties. It suppresses the COX enzyme which eases the production of pro-inflammatory signals in the body. The antioxidants protect your body from free radicals.

Acupuncture Plus Curcumin Protects The Liver
Healthcare Medicine Institute, April 2016
Acupuncture combined with oral curcumin intake protects the liver from fibrosis. Curcumin is the chief curcuminoid in turmeric (Jiang Huang, Rhizoma Curcumae Longae). Curcumin is bright yellow, hence the name ginger yellow in Chinese. Jiang is translated as ginger and huang means yellow. Curcumin is a principle polyphenol in Jiang Huang, a member of the ginger family of herbs used for enhancing blood circulation in Traditional Chinese medicine (TCM). The researchers concluded that acupuncture plus curcumin “potently protected the liver” from injury and fibrogenesis. liver fibrosis.

Turmeric holds cancer related benefits
The News Tribe, April 2016
Curcumin, a bioactive ingredient found in turmeric (Curcuma longa) can prevent and cure bowel cancer (colorectal cancer). So far, anti-cancer properties of curcumin were well-known but the mechanism by which the bright yellow organic compound cures the cancer remained a mystery. The team, headed by R Baskaran, associate professor (biochemistry and molecular biology) at Pondicherry University, discovered the mechanism by which curcumin kills hereditary non-polyposis colorectal cancer cells and documented their findings. `Molecular and cellular biochemistry’, a and cellular biochemistry’, a peer-reviewed international journal brought out by Springer Science+Business Media, New York, published their research paper in its March, 2016 edition. The team included Hemanth Naick, a PhD student of Pondicherry University, and Shunqian Jin, a researcher at University of Pittsburgh cancer institute.

Curcumin in turmeric kills colon cancer cells
Times of India, March 2016
Studies on the effect of curcumin on cancer and normal cells will be useful for the ongoing preclinical and clinical investigations on this potential cancer chemo-preventive agent.

Researchers in Pondicherry University shed light on how curcumin kills tumors
The Hindu, March 2016
Curcumin, derived from the dietary turmeric (Curcuma longa) is an effective anti-cancer, anti-inflammatory, and antioxidant agent. Studies on the effect of curcumin on the entire cell death process, both in tumour and normal cells, are useful for the ongoing preclinical and clinical investigations on this potential chemo-preventive agent. While curcumin’s chemoprevention property is well documented, its ability to kill colorectal cancer cells is not as clearly known or understood. Although curcumin-induced cytotoxicity is due to superoxide anion production, the precise mechanism leading to cell death activation remains unknown. Towards this end, the research group previously reported in a series of publications that human non-polyposis colorectal cancer cells (HNPCC) arising due to genetic mutations in mismatch repair genes (MMR) are highly sensitive to curcumin due to unrepaired DNA damage. In a recent report, published in the international peer-reviewed journal “Molecular and Cellular Biochemistry” (Feb 2016), the authors now document that the protein levels of gadd45a (genes activated during DNA damage), are increased following curcumin treatment. The study demonstrated how the trigger of genes is required for cell death induced by curcumin in colorectal cancer cells and that the mismatch repair (MMR) status strongly influences curcumin sensitivity.

Curcumin prevents weight gain
eMaxHealth.com March 2016
Mohsen Meydani, DVM, PhD, director of the Vascular Biology Laboratory at the USDA HNRCA explained curcumin stopped new blood vessels from growing that make fat spread. The mice also had lower cholesterol and less liver fat.

Health Benefits of Turmeric
Science Mic, March 2016
Curcumin gives turmeric star qualities of being both anti-inflammatory and an antioxidant, which means its consumers will reap external and internal benefits, according to the Washington Post. "It is a known fact that curcumin is a strong antioxidant compound with great ability to scavenge the oxygen-derived free radicals," a 2013 study published in Current Neuropharmacology said. "Consequently, curcumin could be a potential neuroprotective agent." For joint and pain relief, these curcumin capsules were comparable to taking ibuprofen, a 2009 study found. Turmeric has been linked to treating a long list of diseases, such as Alzheimer's and Parkinson's due to its ability repairing brain cells and improving memory in lab rats, the 2013 study said. Another study found curcumin pills to assist in delaying Type 2 diabetes compared to taking a placebo.

The curry cure: Golden spice that could help fight cancer
Express, March 2016
“Curcumin can target a variety of processes which are important in breast cancer development,” he says. “These include reduced proliferation, reduction in potential to spread and increase in programmed cell death of tumour cells.” Recent studies have found that curcumin appears to prevent the formation of molecules that allow circulating tumour cells to spread and attach to other body parts. It is possible that curcumin could interfere with one of the important mechanisms of cancer development. However the benefits of curcumin as an anti-cancer agent may not be restricted to breast well-being. Some studies in humans and from laboratory experiments suggest potential benefit in pancreatic cancer, colorectal cancer and lung cancer.

Curcumin Helps Patients Tolerate Chemo
Newsmax.com March 2016
Studies have shown that curcumin not only enhances the effectiveness of radiation treatment against the cancer, but also protects surrounding normal cells within the treatment area.

Drug-Free Alternatives to Treating Back Pain
Newsmax.com March 2016
Curcumin from turmeric. While turmeric has received much attention in the alternative healthcare field, it’s actually curcumin that has the active compounds that are most effective. It acts on multiple inflammation pathways and neutralizes free radicals — the root causes of pain. Curcumin has been clinically studied on its own and in combination with boswellia for treating people with rheumatoid and osteoarthritis, as well as, or better than, prescription drugs. Scientific studies of human spinal discs treated with curcumin showed an 80 percent reduction in inflammatory compounds and a 70 percent reduction in cartilage-damaging enzyme activity.

Curcumin may prevent liver damage from acetaminophen / paracetemol
J Pharm Pharmacol. March 2016
Curcumin prevented acetaminophen-induced liver damage. Curcumin lessened acetaminophen-induced liver histological damage and increment in plasma alanine aminotransferase and aspartate aminotransferase activity. Additionally, curcumin reduced the decrease in oxygen consumption measured using either succinate or malate/glutamate as substrates (evaluated by state 3, respiratory control ratio, uncoupled respiration, and adenosine diphosphate/oxygen ratio), in membrane potential; in ATP synthesis; in aconitase activity; and in the activity of respiratory complexes I, III, and IV. These results indicate that the protective effect of curcumin in acetaminophen-induced hepatotoxicity is associated with attenuation of mitochondrial dysfunction.

Effect of turmeric on colon histology
BMC Complementary and Alternative Medicine, March 2016
 improved body weight gain, mean macroscopic and microscopic ulcer scores in the colon of rats suffering from acetic acid-induced IBD. CL reduced both MPO and IL-23 in the mucosa of the colon. The increase in the mean serum glutathione level may help in the reduction of oxidative stress associated with IBD.

Expert backs three spices in diet to keep cancer away
Times of India, February 2016
Curcumin proved to be more effective at reducing inflammation than over-the-counter aspirin and ibuprofen, and as effective as the more powerful drug Celebrex. It also proved as effective in thwarting breast cancer cells as tamoxifen, a drug widely used to stop its spread or recurrence.

7 ways turmeric can change your life
Daily O, February 2016
The general consensus is that curcumin, a component of turmeric is the protective agent here. It improves memory, focus and cognition too by increasing the growth of new neurons and fighting various degenerative processes in the brain.

Your Health: Why is everyone raving about turmeric?
NZ Herald, February 2016
Modern scientific research is now confirming what traditional medicine has known - turmeric (and curcumin, the active constituent) has beneficial actions on many bodily systems. Recent studies have revealed turmeric has a wide range of pharmacological and clinical properties, including as an antioxidant, digestive, anti-inflammatory, antiplatelet (decreases clotting), cholesterol lowering and anti-carcinogenic.

What Will Curcumin Do For Me? Stuart’s Dr. True Has The Answer
Stuart Magazine, February 2016
Curcumin is the active component of the spice called turmeric. It has been in use as a spice and traditional medicine for more than 2,500 years. Turmeric is found throughout the world and has a unique name in more than 60 languages. The curcumin extract of turmeric is not new; it was first isolated in 1842. Recent scientific discoveries have confirmed that curcumin may have amazing anti-inflammatory and disease-inhibiting properties. It has the potential to inhibit the growth of many types of cancer, reverse insulin resistance in Type 2 diabetes, inhibit plaque formation in atherosclerosis and address factors that stop the development of Alzheimer's disease. These are just a few of the diseases and maladies that have been researched in the last decade in which curcumin was found to have a positive impact.

Curcumin boosts effect of training on muscles
Ergo-Log.com February 2016
Athletes looking to extend their endurance capacity may achieve better results by taking high doses of curcumin. And curcumin supplementation may also help people who are trying to lose weight by doing intensive cardio training.

Turmeric offers a wide range of health benefits
ConsumerAffairs.com January 2016
As one of the most thoroughly researched plants ever, there are currently 8,421 peer-reviewed articles published which claim to prove the numerous benefits of turmeric. Benefits Packed with anti-inflammatories and antioxidants, turmeric has been shown to fight free radicals, rejuvenate the cells, cleanse the liver, protect the heart, boost mood, and support the brain. It may also be helpful in treating osteoarthritis, viral and bacterial infections, stomach ulcers, cancer, and other conditions. “It’s a very powerful plant,” says Natalie Kling, a Los Angeles-based nutritionist who recommends it to clients for joint pain. Kling says that when taken as a supplement, it helps quickly.

Curcumin Shows Promise as Depression Treatment
Psychiatric Advisor, January 2016
“Curcumin does have an effect on several physiological systems that are implicated in the causes of depression,” Roger S. McIntyre, MD, a professor of psychiatry and pharmacology and head of the Mood Disorders Psychopharmacology Unit at the University of Toronto, told Psychiatry Advisor. “It certainly would be a reasonable hypothesis that it could be in possession of antidepressant properties.” One recent study finding support for the antidepressant effects of curcumin was published in October 2014 in the Journal of Affective Disorders.2 In the randomized, double-blind, placebo-controlled trial, researchers from several universities in Australia assigned 56 patients with MDD to receive either curcumin or placebo capsules twice a day for 8 weeks. Until the fourth week, each group had similar improvements in scores on the Inventory of Depressive Symptomatology self-rated version (IDS-SR30). From the fourth week through the eighth week, however, there was a significantly greater improvement in scores in the curcumin group, especially among patients with atypical depression. “Curcumin can influence several mechanisms in the body; in particular, it is a powerful natural anti-inflammatory and antioxidant,” study co-author Adrian Lopresti, PhD, a clinical psychologist and researcher at the School of Psychology and Exercise Science at Murdoch University, told Psychiatry Advisor. “This has relevance to depression because people with depression have greater inflammation and oxidative stress, which can affect all major organs in the body, including the brain.” Chronic inflammation can decrease levels of serotonin and dopamine and lead to degeneration in certain brain areas. It is possible that the antioxidant and anti-inflammatory effects of curcumin can restore these neurotransmitters and protect the brain, eventually leading to improvements in mood.

Fight depression with turmeric
TheHealthSite.com January 2016
A dose of curcumin increases serotonin as well as dopamine levels in the brain. An imbalance in serotonin levels influences the mood, which can eventually lead to depression, while dopamine is a neurotransmitter that helps control the brain’s reward and pleasure centers.

The anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases
European Journal of Nutrition School of Life Sciences, College of Natural Sciences
Researchers reviewed the last ten years of curcumin science as it applies to supporting weight loss and preventing obesity-related disease. Their conclusion is, “The modulation of several cellular transduction pathways by curcumin has recently been extended to elucidate the molecular basis for obesity and obesity-related metabolic diseases. These findings might enable novel phytochemical treatment strategies as well as curcumin translation to the clinical practice for the treatment and prevention of obesity-related chronic diseases. Furthermore, the relatively low cost, safety and proven efficacy of curcumin make it advisable to include curcumin as part of healthy diet.”

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern target- Bokyung Sung 
Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor κB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail.

  • Spice Rack...Or Medicine Chest?
    Nutrition Action Health Letter
    "Curcumin protects the brain cells in every animal model of traumatic brain injury, whether it's stroke, Alzheimer's disease, Huntington's disease, or mad cow disease," says Gregory Cole, associate director of the Alzheimer's Disease Center at the University of California, Los Angeles. "What's unique about Curcumin," Cole notes, "is that it binds directly to beta-amyloid deposits in the brain and reduces their size." Beta-amyloid is a protein fragment that builds up between brain cells of people with Alzheimer's disease....

    Science Daily Magazine
    How Plants Protect Us From Disease
    "Everyday foods, beverages, and spices contain healthful compounds that help us fight harmful inflammation. And, in doing that, these phytochemicals may also reduce our risk of diseases associated with chronic inflammation, including cancer and diabetes."

    Curcumin

    Curry Power
    Science News Magazine
    "The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive."

     










  • Curcumin at M.D. Anderson Cancer Center
    The University of Texas, MD Anderson Cancer Center
    Curcumin has been shown to prevent a large of number of cancers in animal studies. Laboratory data indicate that Curcumin can inhibit tumor initiation, promotion, invasion, angiogenesis and metastasis. Epidemiological evidence indicate that incidence of certain cancers is less in people who consume Curcumin than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and anti-inflammatory effects at M. D. Anderson Cancer Center and other medical institutions.

    Curcumin

    Spice Healer
    Scientific American Magazine
    An ingredient in curry shows promise for treating Alzheimer's, cancer and other diseases.
    "A chapter in a forthcoming book, for instance, describes the biologically active components of Turmeric--Curcumin and related compounds called Curcuminoids--as having antioxidant, anti-inflammatory, antiviral, antibacterial and antifungal properties, with potential activity against cancer, diabetes, arthritis, Alzheimer's disease and other chronic maladies. And in 2005 nearly 300 scientific and technical papers referenced Curcumin in the National Library of Medicine's PubMed database, compared with about 100 just five years earlier. Scientists who sometimes jokingly label themselves Curcuminologists are drawn to the compound both because of its many possible valuable effects in the body and its apparent low toxicity. They ponder how the spice or its derivatives might be used, not just as a treatment but as a low-cost preventive medication for some of the most feared ailments. As a treatment, it also has some enticing attributes. Because Curcumin targets so many biological pathways, it could have benefits for cancer therapy: malignant cells may be slow to acquire resistance to it and so might have to go through multiple mutations to avoid the substance's multipronged attack." 1 2 3
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  • Prevent Cancer, Heart Disease
    NewsMax.com December 2015
    Many studies have shown that curcumin, the active ingredient in turmeric, protects against many diseases including cancer and Alzheimer's. A study at the University of California, Los Angeles, found curcumin slows the buildup of amyloid plaques — one of the hallmarks of Alzheimer's — in the brain, and a laboratory study at the University of Illinois revealed that curcumin protected cells from damage caused by beta-amyloid. Latest News Update Get Newsmax TV At Home » Special: Researchers at Johns Hopkins University Medical School showed that curcumin protected against the nerve cell damage associated with Parkinson’s disease, and numerous studies have shown curcumin fights many types of cancer including colon, pancreatic, and breast. Read more: Prevent Cancer, Heart Disease With Ethnic Cuisine

    Help for depression and anxiety
    EveryDayHealth.com December 2015
    Curcumin helps mitigate depression and anxiety. The abstract from a 2014 study in the Journal of Affective Disorders reads: Curcumin, the principal curcuminoid derived from the spice turmeric, influences several biological mechanisms associated with major depression, namely those associated with monoaminergic activity, immune-inflammatory and oxidative and nitrosative stress pathways, hypothalamus-pituitary-adrenal (HPA) axis activity and neuroprogression. We hypothesised that curcumin would be effective for the treatment of depressive symptoms in individuals with major depressive disorder.

    Arthritis help may come from a surprising source
    Clinton Herald, December 2015
    Curcumin, the active chemical in the spice turmeric, has several potential uses. I wrote some months ago about its possible use in inflammatory bowel disease, but I was able to find several studies showing benefit in people with both osteoarthritis and rheumatoid arthritis. The usual dose was 500 mg (of curcumin) two or three times daily. There were few side effects in the studies, but there is the potential to worsen bleeding in people taking anticoagulants, such as warfarin. Curcumin seems a reasonable alternative to anti-inflammatories in people with arthritis, and it might be worth a trial, especially in people who experience side effects on the standard drugs. As always, finding a high-quality product is essential, since supplements are largely unregulated.

    Turmeric for Alzheimer's Disease
    About.com Health, December 2015
    Turmeric contains a class of compounds called curcuminoids, which include a substance known as curcumin. Known to possess antioxidant properties, curcumin may play a key role in turmeric's potential effects against Alzheimer's disease. Preliminary research indicates that the curcumin found in turmeric may help curb inflammation and combat oxidative stress, two factors found to contribute to the development of Alzheimer's disease. What's more, some preliminary studies suggest that curcumin may help thwart the Alzheimer's-associated breakdown of nerve cells in the brain. There's also some evidence that turmeric may inhibit the formation of Alzheimer's-related brain plaques. Known to accumulate between nerve cells, these plaques form when protein fragments called beta-amyloid clump together. Beta-amyloid also appears to impair brain function by destroying synapses (structures through which nerve cells transmit signals to one another). In several animal-based studies, scientists have observed that turmeric may help clear beta-amyloid from the brain. For example, a mouse-based study published in Current Alzheimer Research in 2012 found that treatment with turmeric extract significantly reduced brain levels of beta-amyloid in mice genetically engineered to develop symptoms of Alzheimer's.

    The link between cancer and diet
    The News Tribe, December 2015
    Curcumin, anti-ageing factor in this wonder spice. Renders anti-inflammatory and antioxidation benefits, hence used traditionally for a healthy glowing skin. Besides, it also destroys pro-carcinogens, thus protecting against cancer. It is also seen as that inclusion of turmeric in the diet reduces the incidences of senile diseases like Alzheimers.

    Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS).
    Eur J Appl Physiol, December 2015
    Oral curcumin likely reduces pain associated with DOMS with some evidence for enhanced recovery of muscle performance. Further study is required on mechanisms and translational effects on sport or vocational performance.

    Liver Health
    LiveSupport.com November 2015
    Turmeric’s primary chemical compound is curcumin, a yellow substance with a long history of aiding liver health. Numerous studies have linked curcumin to reductions in liver cancer and liver fibrosis. According to a study in a 2012 edition of the Journal of the Medical Association of Thailand, scientists found that the livers of diabetic rats were repaired and even regenerated with the help of turmeric. According to a 2009 study in the journal Liver International, curcumin showed an ability to inhibit several factors (like nuclear factor-kappaB) that helped reduce liver inflammation. In addition, the authors found that curcumin helped protect against liver injury from known liver cell toxins.

    Phytonutrients
    LiveScience.com November 2015
    Curcumin is found primarily in turmeric, a member of the ginger family. It gives turmeric its distinctive yellow color. Because of its curcumin, turmeric has been used as a medicinal remedy in India for centuries, said Premkumar. “The claimed effects of curcumin range from relieving flatulence to curing Alzheimer’s disease and cancer,” said Premkumar. Animal studies have shown good results when looking at oral administration of curcumin and to inhibit the spread of mouth, stomach, liver and colon cancer. Studies are under way to investigate this effect in humans. Curcumin is an effective anti-inflammatory agent and antioxidant. It may also affect carcinogen metabolism, helping the body get rid of toxic compounds, and aid in combating cancer cell growth and tumors, according to the Linus Pauling Institute. All of these factors contribute to its being a potentially effective cancer-prevention agent. Based on successful animal trials, it has been suggested that curcumin could aid in inflammatory diseases like rheumatoid arthritis as well as cystic fibrosis and Alzheimer’s disease, but studies are either not yet under way or are inconclusive, according to the Linus Pauling Institute. According to Premkumar, curcumin can also be helpful in cardiovascular protection by lowering LDL cholesterol levels and increasing HDL (good) cholesterol levels. “Treatment with curcumin selectively increases the expression of low-density lipoprotein (LDL) receptor levels and is able to clear LDL, which is bad or lousy cholesterol,” he said.

    Possible BPH Therapy Seen in Using Curcumin as Dietary Supplement
    BPH News, November 2015
    Recent research revealed curcumin significantly decreases prostate weight and volume in animal models of benign prostatic hyperplasia (BPH). The study entitled “Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model” was published in the journal BMC Complementary and Alternative Medicine. Benign prostatic hyperplasia (BPH) is a common condition affecting elderly men and is characterized by a hyperplastic growth of the prostate gland, causing pressure on the bladder and urethra. Curcumin, one of the primary ingredients in turmeric and curry powders, and with beneficial effects in several diseases including retinal diseases and Parkinson’s disease, was also suggested to enhance degradation of a key receptor in prostate cancer and induce cancer cell death. The team observed that curcumin inhibited the development of BPH, significantly lowering prostate weight and volume. Additionally, authors observed curcumin decreased expression of VEGF, TGF-ß1, and IGF1 when compared to the control group (important growth factors in prostate tissue). These findings suggest that curcumin could potentially be used as an herbal treatment or functional food for BPH management, this way bypassing the adverse side effects observed in commonly used treatments for the condition.

    Maintain liver health with curcumin
    ChiroEco.com November 2015
    Curcumin is the main component of the spice turmeric, giving it a distinctive bright golden coloring. Turmeric is a member of the ginger family and often used as a staple in Indian cooking, particularly as a primary ingredient in curry. Curcumin is thought to prevent the accumulation of fatty acids in the liver, thereby staving off the possibility of NAFLD before it progresses to NASH as well as other liver diseases. Furthermore, curcumin is a powerful antioxidant, so it may also protect against the effects of age on the liver, as well as inhibit the formation of enzymes that can cause cellular death. A 2015 review discussed curcumin’s role in preventing NASH. The study found that curcumin inhibits the activation of hepatic stellate cells, which form scars in the liver following damage.

    Turmeric for disease prevention
    examiner.com November 2015
    Turmeric is made up of compounds called curcuminoids, named for the most well known and main active compound, curcumin. Curcumin is a strong antioxidant and arguably the most effective anti-inflammatory compound, not only fighting inflammation when it occurs, but stopping at the source, before it even begins. It is now believed that every chronic disease, including heart disease, thyroid disease and diabetes, has a strong correlation with chronic internal inflammation that you may not know even exists in your body. That said, regulating your body’s silent inflammatory response by utilizing turmeric and curcumin not only helps manage chronic disease, but is an important disease preventative. In fact, curcumin is so powerful that it is said to rival some anti-inflammatory drugs, even preventing fat accumulation and rebound, a common symptom of chronic inflammation. That is because of it’s anti-angiogenic properties and it’s ability to lower cholesterol levels, thusly reducing overall weight loss.

    Turmeric prevents fear from being stored in the brain
    Mail Online, November 2015
    A spice commonly used in curry could help erase bad memories, according to a study. Curcumin, a bright-yellow compound found in the root of the Indian spice turmeric, prevented new fear memories being stored in the brain, and also removed pre-existing fear memories, researchers found. It is hoped that the findings will help develop treatments for people suffering with psychological disorders. Psychologists from the City University of New York trained rats to become scared when they heard a particular sound. Scientists assumed the creatures were frightened when they froze. Hours later, when the same sound was played to the rats, those who had been given ordinary food froze. Yet the rats fed the curcumin-rich diet didn’t freeze, suggesting their fearful memories had been erased. Professor Glenn Schafe, who led the study, said: ‘This suggests that people suffering from post-traumatic stress disorder and other psychological disorders that are characterised by fearful memories may benefit substantially from a curcumin-enriched diet.’

    Health Benefits of Curcumin
    BT.com November 2015
    Curcumin, a substance found in turmeric, is thought to reduce swelling and ease the pain associated with inflammation of the joints. Curries may help to prevent Alzheimer’s… Researchers have found that curcumin can also reduce the build-up of plaques on the brain that cause Alzeihmer's by as much as 50%. …And cancer Turmeric has been found to reduce the risk of several types of cancer; while a study found that people consuming high levels of cumin were less likely to develop prostate cancer.

    Turmeric is hot and may benefit more than just your taste buds
    Today, October 2015
    Many of the studies have focused on curcumin, which researchers say is the active ingredient in turmeric. A Thai study published in 2014 found that curcumin capsules dulled the pain in arthritic knees just as well as the popular OTC NSAID ibuprofen. A 2015 study in a rat model of Alzheimer's disease found that the spice improved working memory. In fact, the more curcumin the rats consumed, the better their memories got.

    The super healthy trendy root
    Today, October 2015
    Turmeric is getting lots of attention because the active ingredient in it, curcumin, has potent anti-inflammatory properties and has been shown to be beneficial in treating symptoms of Crohn's disease, Irritable Bowel Syndrome and stomach ulcers. There is also research (in both animals and humans) that shows that curcumin may help prevent and slow the spread of cancer, make chemotherapy more effective and protect healthy cells from radiation damage.

    Health benefits of turmeric
    The Gleaner, October 2015
    Turmeric's unique contribution to prostate-cancer-fighting is its extraordinary anti-inflammatory properties, provided chiefly by its natural primary component, curcumin. Reducing inflammation with curcumin reduces the metastases that ultimately kill prostate cancer patients. Curcumin also down-regulates genes involved in adhesion, motility, and invasiveness that prostate-cancer cells need to invade and spread. Curcumin specifically inhibits prostate cancer-cell production of PSA by blocking its genetic expression. At the same time, it also reduces activation of the androgen receptors on cancer cells that trigger increased production of PSA. But the whole turmeric root also contains important oils and other substances that enhance curcumin's absorption and have health benefits of their own, including anti-cancer actions. Turmeric also inhibits the growth of stem cells that give rise to breast cancer without harming normal breast cells.

    The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update
    Food and Chemical Toxicology, October 2015
    Naturally occurring polyphenols (like curcumin, morin, resveratrol, etc.) have gained importance because of their minimal side effects, low cost and abundance. Curcumin (diferuloylmethane) is a component of turmeric isolated from the rhizome of Curcuma longa. Research for more than two decades has revealed the pleiotropic nature of the biological effects of this molecule. More than 7000 published articles have shed light on the various aspects of curcumin including its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer activities. Apart from these well-known activities, this natural polyphenolic compound also exerts its beneficial effects by modulating different signalling molecules including transcription factors, chemokines, cytokines, tumour suppressor genes, adhesion molecules, microRNAs, etc. Oxidative stress and inflammation play a pivotal role in various diseases like diabetes, cancer, arthritis, Alzheimer's disease and cardiovascular diseases.

    Researchers make breakthrough in understanding cancer
    The Eagle, October 2015
    Long-chain omega-3 fatty acids found in fish oil, as well as curcumin, found in turmeric, are in a unique class of dietary bioactives that we have termed membrane-targeted dietary bioactives, or MTDBs. Previous studies suggest that dietary bioactives such as curcumin, as well as fish oil and omega-3 fatty acids, are effective as colorectal cancer preventive agents. Long-chain fatty acids found in fish oil, as well as curcumin and capsaicin, which is found in hot peppers, fall into this unique class because they have both hydrophilic, or water-loving, properties and lipophilic, or fat-loving, properties. Due to their characteristics, these are capable of disturbing cell membrane organization. Membrane-targeted dietary bioactives, such as curcumin and capsaicin, squeeze in between spaces within the membrane leading to disruption of lipid and protein interactions.

    Curcumin supplementation: more glycogen, less lactic acid, more stamina, more strength
    Ergo-log.com September 2015
    Curcumin [structural formula shown below] has been the subject of heated interest from molecular nutritionists in recent years. That's not surprising if you look at the long list of the benefits of curcumin: it inhibits muscle breakdown, enhances the positive effects of exercise on the blood vessels, boosts testosterone levels, inhibits estradiol, strengthen bones

    5 Secret Health Benefits of Spicy Food
    Desi Blitz, September 2015
    Curcumin in particular is said to have anti-inflammatory properties, which break down the bad brain cells linked to Alzheimer’s disease.

    Turmeric Blocks Cancer Cells – Which Chemotherapy Can’t Do
    Food World News, September 2015
    A recent study published in the Asian Pacific Journal of Cancer Prevention, for instance, found that a dose-dependent administration of curcumin effectively activated apoptosis of liver cancer cells, meaning it prompted these harmful cells to die.

    How to improve your circulation
    Stuff.co.nz, September 2015
    Ginger, similar to spicy peppers, can help blood flow, as can turmeric root, which also has anti-inflammatory properties. Turmeric contains curcumin, which is not only a wonderful antioxidant, it also assists blood flow.

    Curcumin inhibits
    Lab Invest,. September 2015
    These findings characterized a novel mechanism by which curcumin modulated hepatocyte EMT implicated in treatment of liver fibrosis

    A glass of turmeric
    DailyTimes.com September 2015
    The major medicinal value and health benefits of turmeric are due to its main ingredient curcumin. Curcumin serves as an anti-inflammatory agent and also possess anti-bacterial and anti-viral properties. These properties make it a powerful healing agent in conditions like common cold. The anti-inflammatory action of curcumin aids in relieving the chest congestion which typically accompanies common cold. Curcumin also helps in boosting immunity and hence makes children less susceptible to such infections. When taken with milk, the absorption of curcumin in the body is enhanced significantly leading to a quick relief from common cold.

    Focus on herbs that can treat diabetes
    TheHindu.com August 2015
    The most active component of turmeric is curcumin, a potential therapeutic agent used in diabetes and related complications. Curcumin could alleviate most aspects of diabetes including insulin resistance, hyperglycemia, hyperlipidemia, islet apoptosis and necrosis effectively. Moreover, Curcumin is safe and relatively inexpensive.

    Three reasons turmeric is a boon for diabetics
    TheHealthSite.com August 2015
    The antioxidant, antimicrobial, anti-inflammatory, and anti-glycaemic properties of curcumin present in turmeric, helps to strengthen the immune system and fight various infections and viruses. Here are some natural remedies that help you boost immunity and stay safe. It helps in weight management: Obesity is a major risk factor of diabetes, accumulation of abdominal fat makes insulin production difficult. However, curcumin helps to control triglyceride and cholesterol levels in the body, improve digestion, prevent the accumulation of harmful fats. This helps in weight management, an important way to manage diabetes or prevent its onset.

    Top 10 super-spices
    Madison.com August 2015
    Curcumin is more effective slowing down the development of Alzheimer’s disease than many medications, because it decreases inflammation and oxidation in the brain. This spice also speeds up the recovery time from strokes as well. Turmeric and its active ingredient, curcumin, are also highly effective against diseases like irritable bowel disease, ulcerative colitis, Crohn’s, and arthritis. Turmeric also improves liver function, lowers homocysteine and prevents heart disease.

    Curcumin shows promise for treatment of mild-to-moderate ulcerative colitis
    Healio.com August 2015
    “The findings of this trial suggest that curcumin as add-on therapy with optimized mesalamine is superior to optimized mesalamine alone in inducing clinical remission in patients with active mild-to-moderate UC,” the researchers concluded.

    New Findings Support Curcumin as Derivative for Use in Fighting Mesothelioma
    MesotheliomaHelp.com August 2105
    According to researchers from Flinders Medical Centre, a teaching hospital and medical school in South Australia, curcumin, the active ingredient in turmeric and the spice that gives curry its yellow color, inhibited the growth of mesothelioma tumor cells in human patient cells. Prior research was focused on animal models. “Curcumin – which can be taken orally in tablet form – has virtually no side effects, and could be used alone in patients too unwell to tolerate other therapies, or in conjunction with other drugs,” said lead researcher and Associate Professor Sonja Klebe, from the Department of Anatomical Pathology at Flinders, in a July 2 article in The Lead. “It may improve treatment response and allow reduction of standard drugs, improving quality of life,” added Klebe... The researchers found that the spice helps combat the cancer by directly affecting the blood supply to the tumors.

    3 Reasons to Include Turmeric in Your Diet
    US News & Health Report, August 2015
    The magic of turmeric resides in the roots, specifically in the chemical compound called curcumin. Curcumin is a polyphenol – a chemical compound found in plants with antioxidant properties and myriad therapeutic attributes. In 2007, a study in Advances in Experimental Medicines and Biology, went so far as to state that, "Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal and anticancer activities, and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses."

    Turmeric Rx: Centuries-old Indian spice may have multiple health benefits
    Pittsburgh Post-Gazette, August 2015
    Curcumin can help prevent or treat a wide spectrum of cancers, inflammatory conditions, autoimmune problems, neurological ailments including Alzheimer’s disease, cardiovascular disease, diabetes and diabetes neuropathy, among other metabolic diseases. Interest in turmeric and curcumin began decades ago when researchers began asking why India has some of the lowest rates of colorectal, prostate and lung cancer in the world, compared with the United States, whose rates are up to 13 times higher. They traced India’s advantages largely to its diet staple of curry powder, which is a combination of spices, with turmeric as a main ingredient. A recent review published in the journal Molecules said studies to date “suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases.” An M.D. Anderson Cancer Center review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that “plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.” Yet another M.D. Anderson study found that curcumin exhibits “antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities,” all bolstering its “potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease and other chronic illnesses.”

    Exciting research shows curcumin spice could help treat mesothelioma
    EmaxHealth.com July 2015
    Curcumin is known for its anti-inflammatory and anti-cancer properties. The turmeric derivative has the ability to stop the growth of mesothelioma, found in animal lab experiments. Now researchers have taken things a step further by testing curcumin's anti-cancer effect in human mesothelioma cells Associate Professor Sonja Klebe, from the Department of Anatomical Pathology at Flinders Medical Centre said in a media release: “Importantly, this breakthrough allows us to predict if a certain patient is likely to benefit from therapy.” Advertisement Current therapy for mesothelioma involves trying to keep the cancer from growing and spreading to other organ. Surgery is not an option for everyone. Chemotherapy has been only partially successful. Curcumin halts blood supply to mesothelioma tumors Klebe explained curcumin has the ability to stop new blood vessels from growing. Cutting off the blood supply to cancer has been a focus of treatment. But the researchers were able to show for the first time that mesothelioma cells form 3-dimensional tubes. “This may explain the poor results of trials with the standard drugs, because they do not target this type of blood vessel formation," Klebe says. The researchers thinks curcumin has a direct affect on mesothelioma tumor growth in addition to stopping blood vessels from growing. “Curcumin – which can be taken orally in tablet form - has virtually no side effects, and could be used alone in patients too unwell to tolerate other therapies, or in conjunction with other drugs. It may improve treatment response and allow reduction of standard drugs, improving quality of life,"

    Treating Mesothelioma with Curcumin: Success May Be Predictable
    SurvivingMesothelioma.com July 2015
    Curcumin is the plant polyphenol that gives turmeric its yellow hue and spicy flavor. It has anti-inflammatory properties and has been shown to inhibit the growth of mesothelioma cells from animal models in the laboratory. Now, for the first time, researchers in Australia say they have successfully done the same thing with human cells taken from their own mesothelioma patients. Researcher Sonja Klebe, an Associate Professor at Flinders Medical Centre in South Australia where the new research was conducted, says the breakthrough will allow doctors to predict whether or not a certain mesothelioma patient will benefit from treatment with curcumin. The research at Flinders may also help explain why curcumin may sometimes work even better than traditional drugs to fight mesothelioma. Dr. Klebe says she and her research colleagues have discovered, for the first time, that mesothelioma cells may be capable of giving rise to their own blood vessels to feed growing tumors. Traditional mesothelioma medications only target blood vessel growth arising from surrounding stromal cells. “This may explain the poor results of the standard drugs because they do not target this type of blood vessel formation,” explains Dr. Klebe. Unlike these drugs, curcumin does appear to impact this type of blood vessel formation, potentially slowing or even reversing the growth of mesothelioma tumors. Curcumin can be taken in a pill form and has virtually no side effects. If the new research findings can be confirmed, Dr. Klebe says curcumin could be added to the standard treatment regimen for some mesothelioma patients, making it possible to reduce the amount of side-effect producing medications they have to take. Mesothelioma is an extremely rare and hard-to-treat cancer affecting an estimated 2,500 American patients every year. It is directly liked to asbestos exposure.

    Spicy treatment for aggressive cancer
    Southern Health News, Flinders Medical Center Publication, July  2015
    Scientists at Flinders Medical Centre say they have successfully used the plant polyphenol curcumin to slow the growth of mesothelioma cells taken from their own patients. To understand how this new research may impact future treatment, click here to read the article Surviving Mesothelioma has just posted. Curcumin comes from the plant that produces the spice turmeric. Although it has been used to slow the growth of mesothelioma cells taken from animal models, the new research represents the first time the same thing has been done with cells from human mesothelioma patients.

    Rediscovering the Cancer-Fighting Power of Turmeric
    Asbestos.com July 2015
    Historical evidence dating back thousands of years shows people in China and India often used curcumin to treat a number of conditions, from coughs and colds to skin diseases and wounds. Although it's been touted for its anti-inflammatory and antioxidant properties, tests to confirm further medicinal properties over the last few decades show mixed results. But the popular spice is back in the limelight thanks to modern clinical trials evaluating the compound's cancer-fighting properties. Clinical Trials Involving Curcumin and Cancer Many studies have shown curcumin can suppress tumor cells and is safe to consume even at high doses. Researchers at Case Western Reserve University School of Medicine in Ohio and Georg-Speyer-Haus research institute in Frankfurt, Germany, published a study in September 2014 titled, "Curcumin, Special Peptides Boost Cancer-Blocking PIAS3 to Neutralize Cancer-Activating STAT3 in Mesothelioma." The study on tissue samples showed how curcumin activates the specific protein that can slow or stop the growth of mesothelioma cells. Professor of medicine at Case Western Reserve University and lead researcher of the study, Afshin Dowlati, M.D., told Asbestos.com the study "is very significant." Although the study wasn't performed on humans, Dowlati said curcumin "has shown clearly that it can reduce the cancer growth."

    COX-2 inhibitors, conventional and natural, including curcumin
    MyDigitalFC.com July 2015
    Curcumin, the herbal aspirin, has been shown to inhibit certain growth factors. Every tumour needs blood supply and curcumin seems to impede them. Research suggests that curcumin ‘reawakens’ a key tumour-suppressor gene. It also inhibits metastases, especially in prostate and breast cancer, and quells other cancer cells, besides preventing the re-growth of cancer stem cells which populate the core of several tumours. New research hails curcumin as a ‘holistic’ anti-cancer herb, because of its success in not only halting cancer formation, replication and spread, but also providing the synergy to other anti-cancer drugs, while protecting healthy cells and organs. Research in the UK evidences that curcumin and chokeberry, for instance, can work together to induce cancer cell death (apoptosis) and prevent the spread of malignant cancer cells. Studies also suggest that curcumin can prevent cancer stem cells from re-growing the tumour. Recent research has shown curcumin can dexterously counter the dangerous effects of hormone replacement therapy (HRT) and its hazardous relationship with breast cancer. According to clinicians women could take curcumin supplements to protect themselves from developing progestin-accelerated tumours, primarily because synthetic progestin increases vascular endothelial growth factor (VEGF), a protein that helps form the blood supply to developing tumours. Curcumin inhibits VEGF and, thus, reduces the potential of breast cancer to proliferate.

    Formation of Neural Tube Defects Reduced by Curcumin
    EndocrinologyAdvisor.com July 2015
    Curcumin appears to reduce high glucose-induced neural tube defect (NTD) formation by blocking cellular stress and activation of caspases, according to an experimental study published in the June 4 issue of the American Journal of Obstetrics & Gynecology... Under high-glucose conditions, curcumin suppressed oxidative stress in embryos. Treatment correlated with reductions in the levels of the lipid peroxidation marker, 4-hydroxynonenal, nitrotyrosine-modified protein, and lipid peroxides. In addition, curcumin blocked endoplasmic reticulum stress and abolished caspase 3 and 8 cleavage in embryos cultured under high-glucose conditions.

    Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis
    Am J Obstet Gynecol July 2015
    Curcumin reduces high glucose-induced NTD formation by blocking cellular stress and caspase activation, suggesting that curcumin supplements could reduce the negative effects of diabetes on the embryo. Further investigation will be needed to determine if the experimental findings can translate into clinical settings.

    5 supplements every man should take

    Personal Liberty Digest July 2015
    Curcumin has been studied as a potential cancer-fighting agent and has demonstrated an ability to reduce prostate cancer tumors. The authors of a new study in Tumour Biology, for example, reported on a mechanism by which curcumin inhibits the growth of prostate cancer cells. Curcumin also helps support prostate health in men who have prostatitis and benign prostatic hyperplasia. In addition, the compound is a potent antioxidant valued for its ability to reduce inflammation and pain in conditions such as osteoarthritis, as well as act as a blood thinner and immune-system booster. Curcumin has shown anti-diabetic effects and reduced diabetic complications.

    Curcumin inhibits growth of prostate carcinoma
    Tumour Biology July 2015

    Prostate cancer (PC) is a prevalent cancer in aged men. Curcumin is an active ingredient that has been extracted from the rhizome of the plant Curcuma longa. Recently, a potential of Curcumin against PC has been reported in PC


    West discovers health benefits of Indian spice turmeric

    Press of Atlantic City July 2015
     A recent review published in the journal Molecules said studies to date "suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases." An M.D. Anderson Cancer Center review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that "plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases." Another M.D. Anderson study found that curcumin exhibits "antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities," all bolstering its "potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses.


    6 foods that help fight cancer
    Cosmopolitan February 2015
    This popular curry spice contains an active compound called curcumin (it's what gives turmeric its bright yellow-orange colour) which has been shown to display powerful anti-cancer activity. In fact, curcumin has the most evidence-based literature supporting its use against cancer of any nutrient. Professor Bharat Aggarwal, from the MD Anderson Cancer Center in Texas goes as far as saying, "No cancer has been found, to my knowledge, which is not affected by curcumin." Pretty powerful stuff then!

    Turmenic Can Erase Bad Memories And Fight Mental Disorders
    Wall Street OTC February 2015
    The research stated that an ingredient found in turmenic, called curcumin is involved in the process of both helping the printing of the new fears a person is dealing with and also at erasing existent negative memories. This new discovery, might come in the help of researchers for developing treatments for people suffering from mental disorders.

    Turmeric: The New Superfood
    Inquisitr.com February 2015
    Curcumin (not related to cumin) is an antioxidant and the active ingredient in turmeric. Although it is continuously being studied, curcumin has been shown to inhibit several types of cancer cells. According to the American Cancer Society, turmeric is mostly used as an anti-inflammatory herbal remedy, with fewer side effects than common pain relievers.

    Top Herbs, Latest Research
    naturalproductsinsider.com February 2015
    Curcumin has sparked a variety of scientific exploration into new areas, as research has recently indicated the compound can boost levels of the omega-3 docosahexaenoic acid (DHA) in the brain, where it can positively affect cognitive health. Also, drug discovery scientists have focused on novel analogs of curcumin in an effort to find compounds that have similar health benefits and overcome some of the absorption and stability challenges with the herb.

    Turmeric Beneficial for Brain Health
    Newswire.net February 2015
    A recent study showed that curcumin encourages the immune system to send macrophages to the brain. A clinical trial was performed that involved people with severe cognitive decline to test the effects of curcumin. The results showed that participants taking curcumin had significantly higher levels of dissolved abnormal proteins in their blood compared to those in the placebo group. This study showed that curcumin has the ability to effectively pass into the brain, bind to beta-amyloid plaques and assist the body in their breakdown. Curcumin is one of the only substances known to have such a profound protective effect on the brain.

    Curcumin: This compound in turmeric can boost your heart health
    TheStar.com February 2015
    Adding spice – in the form of curcumin supplements – to the daily diets of people with risk factors for heart disease may lower inflammation, a new study suggests.

    Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials
    Sciencedirect.com February 2015
    This meta-analysis showed a significant effect of curcuminoids in elevating serum SOD and catalase activities, GSH concentrations, and reduction of serum lipid peroxides.

    Effect of curcumin supplementation on physiological fatigue and physical performance in mice
    Nutrients. February 2015
    Curcumin is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities....Curcumin supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

    Turmeric Beneficial for Brain Health
    NewsWire.net, February 2015
    A recent study showed that curcumin encourages the immune system to send macrophages to the brain. A clinical trial was performed that involved people with severe cognitive decline to test the effects of curcumin. The results showed that participants taking curcumin had significantly higher levels of dissolved abnormal proteins in their blood compared to those in the placebo group. This study showed that curcumin has the ability to effectively pass into the brain, bind to beta-amyloid plaques and assist the body in their breakdown. Curcumin is one of the only substances known to have such a profound protective effect on the brain

    Curry spice linked to improved memory
    The Guardian, February 2015
    Curcumin, a bright-yellow compound found in the root of the Indian spice turmeric, prevented new fear memories being stored in the brain, and also removed pre-existing fear memories, researchers found.

    Curcumin prevented new fear memories being stored in the brain and removed pre-existing fear memories
    Mail Online, February 2015
    Curcumin is known to have an anti-inflammatory effect on the body, and this may be how it works on fearful memories, said Professor Schafe.‘Inflammatory processes have been implicated in a wide range of diseases ranging from allergies to cardiovascular disease to Alzheimer’s,’ he said.‘Inflammation has also been implicated in psychological disorders such as depression, anxiety and post-traumatic stress disorder.‘Some of these same inflammatory pathways have also been implicated in memory formation, so it all fits.

    Curcumin's ability to fight Alzheimer's studied
    Science Daily, January 2015
    Curcumin, a natural product found in the spice turmeric, has been used by many Asian cultures for centuries, and a new study indicates a close chemical analog of curcumin has properties that may make it useful as a treatment for the brain disease. “Curcumin has demonstrated ability to enter the brain, bind and destroy the beta-amyloid plaques present in Alzheimer’s with reduced toxicity,” said Wellington Pham, Ph.D., assistant professor of Radiology and Radiological Sciences and Biomedical Engineering at Vanderbilt and senior author of the study, published recently in the Journal of Alzheimer’s Disease.

    The Spice Ingredient That Can Block Bad Memories
    Time Magazine, January 2015
    Curcumin, a compound found in turmeric that may have protective effects against neurodegenerative diseases, might one day help those with PTSD let go of bad memories, suggests a new rat study published in the journal Neuropsychopharmacology.

    Reduce Heart Disease with Turmeric – It’s Just as Effective as Exercise and Cholesterol-Reducing Drug
    The Raw Food World, January 2015
    One study found that curcumin contains anti-thrombotic, anti-proliferative, and anti-inflammatory effects and can decrease the serum cholesterol level and protect against atherosclerosis. Several studies show the major benefit of curcumin for heart disease is improving the endothelium function in the lining of the blood vessels. Endothelium dysfunction is the main cause of heart disease and causes the endothelium to inefficiently regulate blood pressure, blood clotting, and other factors. Not only did curcumin help endothelial function, but also one study found that it’s just as effective as exercise.In addition, another study showed that it works just as well as the drug Atorvastatin. One study showed that 121 patients who underwent coronary artery bypass surgery were randomized to ingest either 4 grams of curcumin per day, a few days before and after the surgery, or a placebo. The results show that the group who ingested curcumin had a 65% decreased risk of experiencing heart attack whilst in the hospital. The authors state, “The antioxidant and anti-inflammatory effects of curcuminoids may account for their cardioprotective effects shown in this study.”

    Treat Rheumatoid Arthritis with the Natural Healing Effects of Turmeric
    The Raw Food World, January 2015
    Curcumin is used to treat everything from skin and stomach ailments to infections and inflammations. Other research shows curcumin helps reduce Alzheimer’s. Now modern researchers have been intrigued enough to put turmeric’s many historical benefits to the test – even rheumatoid arthritis.

    Turmeric associated with fewer neural tube defects in mice
    2minutemedicine, January 2015
    In the present work, authors investigate the impact of curcumin, a substance found in the turmeric plant, on NTDs and markers of oxidative stress in mouse embryos cultured in normal and high glucose environments. They found that embryos cultured in high glucose environments and treated with 20μM curcumin were less likely to experience oxidative stress and develop NTDs.

    Curcumin in turmeric fights BP, diabetes: Study
    Times of India, January 2015
    The health benefits of turmeric are due to the presence of a yellow compound named curcumin. This compound is especially beneficial for fighting high blood pressure. Remarkably, this compound is not only helpful in regulating blood pressure but also effective in treating several late complications of diabetes like affecting eyes, blood vessels, kidney and brain.

    A Common Kitchen Item Could Cure All Your Fears And Bad Memories
    Carbonated.tv January 2015
    Curcumin (a compound found in turmeric) has been found to possess the power to impair newly acquired and reactivated fear memories. The spice is vastly acknowledged for its medicinal properties, and contains anti-inflammatory bodies which are known to help with arthritis and stomach issues, among many other ailments.

    Natural Interventions to Keep Your Eyesight Sharp as You Age
    The Raw Food World, January 2015
     Curcumin, found in turmeric, contains a high amount of therapeutic polyphenol and is the reason for its golden color. Turns out that curcumin is able to protect against cataracts forming. (2) One study shows that curcumin had the potential to function as an anticataractogenic agent, which could possibly prevent the accumulation of calcium in the eye lens. (6) Another study showed the antioxidant effects of curcumin that appears to prevent oxidative damage and delay cataracts.

     

    Curcumin and major depression: A randomised, double-blind, placebo-controlled trial
    Neuropsychopharmacology. December 2014
    Curcumin supplementation influences several biomarkers that may be associated with its antidepressant mechanisms of action. Plasma concentrations of leptin and endothelin-1 seem to have particular relevance to treatment outcome.

    Curcumin inhibits proliferation of gastric cancer cells
    World Journal of Surgical Oncology December 2014
    Curcumin incubation significantly induced loss of MMP in SGC-7901 cells in a dose- dependent manner (P <0.05); the cell apoptotic rate also dramatically increased after curcumin incubation in a dose-dependent manner (P <0.05).

    Curcumin inhibit leptin gene expression and secretion in breast cancer cells
    Cancer Cell International December 2014
    Curcumin inhibits the expression and secretion of leptin and it could probably be used as a drug candidate for the breast cancer therapy through the leptin targeting in the future.

    Curcumin, curry are spice superstars
    Harold-Review.com December 2014
    More than 900 published research papers pertaining to curcumin’s anticancer activity. One of these papers found that curcumin has the ability to make some cancer cells commit suicide.

    Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
    Biological Research December 2014
    Hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.

    Curcumin and tackling mesothelioma
    News Medical December 2014
    As previous researchers had already demonstrated that curcumin can increase PIAS3, we used curcumin to increase the PIAS3 levels in mesothelioma cancer cells. When we exposed these cells to low levels of curcumin, we saw an increase in the intracellular levels of PIAS3. Furthermore, when we increased PIAS3, the activation of STAT3 decreased, and, in turn, the cancer cells started growing much more slowly or stopped growing altogether. So, curcumin affects mesothelioma cells by increasing the intracellular PIAS3 and therefore decreasing the STAT3 activation and cancer cell growth.

    Five Benefits You Need To Know About The Ingredient That Helps Make Curry
    YouthHealingMag.com December 2014
    The active ingredient in turmeric is curcumin, which is known as a powerful antioxidant. This means it targets dangerous free radicals in the body and reduces the damage they are able to cause DNA and cells.A study in the Sept 2014 issue of Life Sciences performed an extensive review on curcumin and wound/injury healing. Researchers found turmeric (curcumin) to have beneficial properties that appear to speed the wound healing process. These modes of action include the modulation of inflammation and oxidation, the ability to improve granulation tissue formation, tissue remodeling, and deposition of collagen. Curcumin may be able to prevent the oxidation of cholesterol in the body. Since oxidized cholesterol is what damages blood vessels and builds up in the plaques that can lead to heart attack or stroke, preventing the oxidation of new cholesterol may help to reduce the progression of atherosclerosis and diabetic heart disease.

    Unique Health Benefits Of Turmeric
    Lifehacker November 2014
    Curcumin, contained in turmeric, gives it powerful anti-oxidant properties, making it a strong agent against cancer. Experts say that turmeric is naturally anti-inflammatory, and while it's not a one-stop cure against the disease, it does inhibit neoplastic growth by preventing the formation of tumor blood vessels. About 30 studies exist that suggest curcumin has anti-tumor effect.

    Oral curcumin shown effective in psoriasis
     Skin & Allergy News Digital Network November 2014
    Studies have shown that curcumin has antiproliferative, antiangiogenic, and anti-inflammatory effects. In a small study by other investigators, topical turmeric not only successfully cleared psoriasis lesions, it also suppressed phosphorylase kinase activity, which is important to keratinocyte proliferation

    How Curry Can Kill Cancer Cells
    Care2.com October 2014
    In cancer cells, curcumin, the pigment in the spice turmeric that makes curry powder yellow, upregulates and activates death receptors (as shown in human kidney cancer cells, skin cancer cells, and nose and throat cancer cells). Curcumin can also activate the death machine directly (as shown in lung cancer and colon cancer). Caspases are so-called “executioner enzymes,” that when activated, destroy the cancer cell from within by chopping up proteins left and right—kind of like death by a thousand cuts. And that’s just one pathway. Curcumin can also affect apoptosis in a myriad other ways, affecting a multitude of different types of cancer cells. It also tends to leave normal cells alone for reasons that are not fully understood. Overall, researchers “showed that curcumin can kill a wide variety of tumor cell types through diverse mechanisms. And because curcumin can affect numerous mechanisms of cell death at the same time, it’s possible that cancer cells may not easily develop resistance to curcumin-induced cell death like they do to most chemotherapy.”

    Turmeric extract can have the potential to boost brain stem cells
    TheRawFoodWorld,com October 2014
    Curcumin is one of the ingredients in turmeric that exhibits over 150 potentially therapeutic activities and researchers have found it to play a significant role in improving Parkinson’s, Alzheimer’s, and stroke damage...Dr. William LaValley is one of the leading natural medicine cancer physicians. He actually devoted his time in researching the science of curcumin, which has the most evidence-based literature supporting its use against cancer of any other nutrient. He explained, “The curcumin molecule may cause either an increase in activity of a particular molecular target, or a decrease/inhibition of activity. Either way, studies repeatedly show that the end result is a potent anti-cancer activity.”

    Wonder Herb
    MyDigitalFC.com October 2014
    Curcumin is the colouring principle of turmeric — it is the element that gives the herb its yellow hue. Aside from being the most important component of turmeric, curcumin is responsible for the herb’s anti-inflammatory effects. Research suggests that curcumin, like cayenne, another medicinal spice found in chillies, depletes substance P, the pain receptor and neurotransmitter, in the nerve endings (nociceptors). Research also suggests that curcumin and related compounds suppress pain through a mechanism similar to conventional coxib-2 inhibitors — the ‘new’ class of non-steroidal anti-inflammatory drugs (NSAIDs)...Laboratory and animal studies suggest that curcumin has the potential to prevent and treat various forms of cancer: colon, prostate, breast, and skin. As a matter of fact, there has been a substantial amount of research on turmeric’s anti-cancer potential and the results are promising. In one clinical study, researchers examined the pain-relieving properties of curcumin and/or whether it could suppress coxib-2 expression in human colon cancer cells. After exposing colon cancer cells to curcumin, they found the compound not only subdued cell growth, but also downgraded the expression of coxib-2 on the basis of a time- and dose-formatted chart. In addition, researchers observed that curcumin appeared to be a safe, natural coxib-2 inhibitor in human patients.

    Carcinogen Blocking Effects of Turmeric
    Care2.com October 2014
     Curcumin, present in the Indian spice turmeric, which is used in curry powder, is one such agent that is currently under clinical investigation for cancer chemoprevention.” According to their mode of action, chemopreventive agents are classified into different subgroups: antiproliferatives, antioxidants, or carcinogen-blockers. Curcumin belongs to all three, given its multiple mechanisms of action. Curcumin appears to play a role helping to block every stage of cancer transformation, proliferation, and invasion, and may even help before carcinogens even get to our cells. A study back in 1987 investigated the effects of curcumin on the mutagenicity (DNA mutating ability) of several toxins and found that curcumin was an effective antimutagen against several environmental and standard mutagenic and cancer-causing substance.

    Curcumin inhibits breast cancer stem cell migration.
    Stem Cell Research Therapy October 2014
    Curcumin, a plant ployphenol, has several anti-tumor effects and has been shown to target CSCs. Here, we aimed at evaluating (i) the mechanisms underlying the aggravated migration potential of breast CSCs (bCSCs), and (ii) the effects of curcumin in modulating the same...Cumulatively, our findings disclose that curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative feedback loop.

    Health Benefits Of Turmeric
    Huffingtonpost.com October 2014
    Curcumin, the compound in turmeric responsible for that bright hue, is behind a whole host of the health benefits attributed to the spice. A 2012 study examined one perk of curcumin in particular: the ability of the extract to prevent heart attacks among bypass patients. The study followed 121 patients who had bypass surgery between 2009 and 2011. Three days before surgery through five days after, half of the patients took curcumin capsules, while the other half took placebo pills. During their post-bypass hospital stays, more people in the placebo group experienced a heart attack (30 percent) compared with those in the curcumin group (13 percent), Reuters reported. While not a substitute for medication, the researchers pointed out, the antioxidant and anti-inflammatory properties of curcumin may contribute to as much as a 65 percent lower chance of heart attack among bypass patients. ... Among people with prediabetes, curcumin capsules were found to delay the onset of Type 2 diabetes in a 2012 study. Over nine months, study participants were given either curcumin supplements or placebo capsules. Just over 16 percent of people taking the placebo pill were diagnosed with Type 2 diabetes by the end of the study, while no one taking curcumin was. Again, researchers chalk these results up to the anti-inflammatory and antioxidant powers of the compound. ... While studies in humans are still in very early stages, lab and animal studies have shown promising effects of curcumin in the fight against cancer. Curcumin "interferes with several important molecular pathways involved in cancer development, growth and spread," according to the American Cancer Society, even killing cancer cells in the lab setting and shrinking tumors and boosting the effects of chemotherapy in animals.

    Turmeric enhances mood in depression research trial
    Medicalxpress.com October 2014
    Curcumin was significantly more effective than the placebo in improving several mood-related symptoms in the volunteers. The compound had an even greater efficacy in a small subgroup of individuals with atypical depression, which can be characterised by significant weight gain or increased appetite and hypersomnia. "In animal-based studies curcumin has been consistently shown to have antidepressant effects and it has been hypothesised that curcumin would have antidepressant effects in people with major depression," said Dr Lopresti, who is a clinical psychologist in a private practice. "There have been a few positive human-based studies investigating the effects of curcumin in depression. However, this is the first randomised, double blind, placebo-controlled study and over the longest duration.

    Shows Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism
    Yumanewsnow.com October 2014
    The researchers treated human colon cancer tumor cells with curcumin. "We discovered that curcumin turns off the active form of cortactin," said Radhakrishnan, who led the experiments in the lab. "Thus, when cortactin is turned off, cancer cells lose the ability to move and can't metastasize to other parts of the body." More specifically, curcumin "turned off" cortactin by interacting with, and activating, an enzyme known as PTPN1. This enzyme acts as a phosphatase to remove phosphate groups from cortactin – a process known as "dephosphorylation." "This effect, essentially known as 'dephosphorylating cortactin' correlated with reduced ability of colon cancer cells to migrate," Kiela said. "This suggests that curcumin reduces cancer cells' ability to migrate, meaning the cancer can't metastasize."

    Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells
    Biomedcentral.com October 2014
     Curcumin suppresses the expression level of FABP5 and PPARβ/δ in triple negative mammary carcinoma cells. By targeting the FABP5/PPARβ/δ pathway, curcumin prevents the delivery of retinoic acid to PPARβ/δ and suppresses retinoic acid-induced PPARβ/δ target gene, VEGF-A. Our data demonstrates that suppression of the FABP5/ PPARβ/δ pathway by curcumin sensitizes retinoic acid resistant triple negative breast cancer cells to retinoic acid mediated growth suppression.

    Reverse Alzheimer’s, Parkinson’s and Rheumatoid Arthritis with ashwaganda, curcumin and Vitamin D
    Therawfoodworld.com October 2014
    It appears that ashwaganda, curcumin, Vitamin D and exercise may help the body remove amyloid protein, which is thought to cause diseases such as Alzheimer’s, Parkinson’s Disease, Rheumatoid Arthritis and several other amyloid diseases.

    Oral curcumin may protect gut function
    Healthcanal.com October 2014
    Oral curcumin may be a viable therapy to improve intestinal barrier function changes caused by consuming a high-fat Western diet, according to a preclinical study by Virginia Commonwealth University School of Medicine researchers.

    Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages
    Journal of Translational Medicine October 2014
    Curcumin exerts well-known anti-inflammatory and antioxidant effects and probably has a protective role in the atherosclerosis.

    Curcumin fights Alzheimer's disease
    Foodconsumer.org October 2014
    A study led by scientists at Beijing University of Chinese Medicine in Beijing, China suggests taking curcumin supplements may help prevent Alzheimer’s disease...Curcumin is an important supplement that may be used to prevent or treat cancer, inflammatory diseases, cystic fibrosis, and diabetes mellitus and many other diseases in addition to Alzheimer's disease. 

    Colon cancer metastasis blocked by curcumin
    Oncologynurseadvisor.com October 2014
    Curcumin, derived from the spice turmeric, blocks the protein cortactin in colon cancer.

    Study promotes turmeric as promising anti-cancer agent
    GroundReport.com October 2014
    Curcumin could provide an alternate means to the prevention of cancer. The effect of curcumin as an antioxidant, antibacterial agent and anti-tumor agent are well documented and it also has a therapeutic or preventive effect on several other diseases. The study looks at the chemopreventive effects of curcumin in cancer-prevention with specific focus on curcumin’s effect on the regulation of cell signaling and genetic pathways. Further, the study notes that turmeric and curcumin show no significant toxicity at all.

    Healthy Living with Ruth Holmes: Ancient herb used as treatment
    Stroud News and Journal September 2014
    The bright yellow pigment contains the active compound curcumin, which is found in the roots of certain tropical plants like turmeric, and has powerful anti-inflammatory actions.  Just like the non steroidal anti inflammatory medications, it blocks the formation of the pro-inflammatory prostaglandins, and leukotrienes (also inflammatory) but does not have the side effects on the stomach that the anti-inflammatory would. as an anti-inflammatory effect on the stomach.  Curcumin is highly recommended in osteoarthritis and rheumatoid arthritis as well as post operative inflammation.  Curcumin can also be used as a poultice for inflammatory skin conditions like psoriasis and eczema, this herb will not treat any pain, as its action is to reduce and prevent further inflammation from occurring which is what causes the discomfort in the first place.

    Mesothelioma Patients May Benefit from Common Spice
    MesotheliomaLawyerCenter.org September 2014
    A new study on combating mesothelioma suggests that the component curcumin, found in the popular turmeric spice, may help fight mesothelioma by increasing protein inhibitors that can slow down the cancer. Conducted by experts and doctors at Ohio’s Case Comprehensive Care Center and Germany’s Georg-Speyer-Haus Institute for Biomedical Research, the study focused on a protein known as STAT3, which is known to trigger and promote the growth of cancers. When victims have a lower level a PIAS3, an enzyme that fights STAT3, they have an increased chance of dying from mesothelioma. However, when curcumin was administered to patients, their PIAS3 increased, thus fighting off the protein that increases cancer.

    Get your glow from kitchen
    Wonderwoman.intoday.in September 2014
    Curcumin: An antioxidant derived from the turmeric root, its active ingredient can help calm swelling and reduce wrinkles and other signs of ageing.

    Curcumin could slow down progression of lung lining cancer
    Thehealthsite.com September 2014
    Curcumin show promise in slowing the progression of mesothelioma, a cancer of the lung’s lining often linked to asbestos

    Curcumin, The Asian Spice, Helps Fight Mesothelioma
    Medicaldaily.com September 2014
    Curcumin, has long been known for its cancer-inhibiting properties. But when it's combined with cancer-destroying peptides (bonded chains of amino acids), the resulting molecule promotes growth of a protein inhibitor known to combat the progression of mesothelioma.

    Component in Spice May Help Slow Mesothelioma Growth
    Survivingmesothelioma.com September 2014
    Yet another study has demonstrated the potential mesothelioma-fighting properties of curcumin, an anti-inflammatory polyphenol that is the primary component in the spice turmeric. The latest study suggests that applying curcumin along with cancer-fighting peptides may increase the levels of a protein inhibitor that can slow the progression of mesothelioma.
    October 2014

    Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells
    BMC Cancer September 2014
    Treatment of retinoic acid resistant triple negative breast cancer cells with curcumin sensitized these cells to retinoic acid mediated growth suppression, as well as suppressed incorporation of BrdU. Further studies demonstrated that curcumin showed a marked reduction in the expression level of FABP5 and PPARbeta/delta. We provide evidence that curcumin suppresses p65, a transcription factor known to regulate FABP5.

    Curcumin boosts testosterone level
    ergo-log.com August 2014
    Curcumin might be used as an alternative drug for the treatment of male infertility problems.

    The new blockbuster nutrient?
    Theage.com.au August 2014

    Turmeric, with its active ingredient curcumin, are "blockbuster nutrients", according to professor Marc Cohen, head of Complementary Medicines at RMIT. "Turmeric is a powerful antioxidant which stops lipid oxidation and is anti-inflammatory," says Cohen, who devoted an entire chapter to turmeric in his book, Herbs and Natural Supplements: An Evidence-Based Guide. "It is a possible aid in preventing chronic degenerative diseases like Alzheimer's disease."

    Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
    Newindianexpress.com August 2014
    Curcumin, the principal curcuminoid derived from turmeric influences several biological mechanisms associated with major depression, namely those associated with monoaminergic activity, immune-inflammatory and oxidative and nitrosative stress pathways, hypothalamus-pituitary-adrenal axis activity and neuroprogression, the study said. It is effective for the treatment of depressive symptoms in individuals with major depressive disorder. Curcumin is the substance in turmeric which gives the yellow color.

    Eat to Beat Cancer
    aarp.org August 2014
    Laboratory studies have found that curcumin—the main ingredient in the spice turmeric, which gives curry its characteristic yellow color and sizzle—can fight against cancerous changes in healthy cells as well as slow the growth of malignant cells. Some evidence suggests that curcumin may also offer protection against brain tumors.

    Turmeric’s Cardiovascular Benefits Found To Be As Powerful As Exercise
    TheEpochTimes.com August 2014
    Curcumin may prevent the age-associated decline in endothelial function in postmenopausal women
    .

    Powdered Gold
    Cltampa.com August 2014
    With more than 50 healing properties, modern research has found that the effectiveness of turmeric stems from curcumin, a natural compound it contains that is rich in antioxidants and anti-inflammatory ability. Thousands of animal and human studies have been conducted on turmeric and curcumin as both a preventive and curative agent. Current research targets curcumin’s efficacy in treating some of the world’s biggest health threats including cancer, heart disease, type 2 diabetes and Alzheimer’s disease.A number of curcumin studies have shown promising results. Curcumin can kill cancer cells in laboratory dishes and also slows the growth of the surviving cells. Curcumin has been found to reduce development of several forms of cancer in lab animals and to shrink animal tumors. On the U.S. National Library of Medicine’s website, 2,840 abstracts are listed about the study and benefits of turmeric and curcumin.

    Mechanism of curcumin resistance to human cytomegalovirus in HELF cells
    BMC Complementary and Alternative Medicine August 2014
    Curcumin anti-HCMV effect may possibly be that curcumin concurrently alters host cell microenviroment and inhibits the HCMV antigen expressions. These findings may provide a basic understanding of the curcumin anti-HCMV effect and a novel strategy for further development of curcumin anti-HCMV treatment.

    What's the one cooking trick for weight loss success?
    Nola.com July 2014
    Turmeric, the yellow ground spice you find in curry power, is a superspice when it comes to health and weight loss because of its active compound called curcumin. Hundreds of studies have been completed on its effectiveness against cancer, skin ailments, and lung health, just to name of few. But when it comes to the battle of the bulge, turmeric extract suppressed fat tissue growth in rodent models.

    Turmeric branded latest superfood to protect against Alzheimer's
    Business-Standard.com July 2014
    Since inflammation is a major factor in the development of most chronic degenerative diseases including cardiovascular disease, allergies, type 2 diabetes and Alzheimer's disease, curcumin's anti-inflammatory power holds great promise in all of these conditions and many more. Murray said that the antioxidant activity of curcumin is superior to antioxidant nutrients like vitamin C and E, as they are effective against only water and fat-soluble pro-oxidants. Curcumin also helps in preventing LDL cholesterol - one of the worst kind of cholesterol - from getting oxidised and damaging arteries. and evidence is gaining that curcumin could also slow down ageing and prevent age-related diseases.

    Healthiest Foods
    palmbeachillustrated.com July 2014
    Curcumin: An active ingredient in turmeric, this antioxidant has shown anti-cancer effects in laboratory studies and is anti-inflammatory.

    Turmeric, Curcumin fights Alzheimer's disease
    Foodconsumer.org July 2014
    Curcumin one of the active ingredients found in turmeric has been known to protect against cancer, Alzheimer's disease, type 2 diabetes mellitus, allergies, arthritis and other chronic diseases. Epidemiological studies show that incidence of Alzheimer's disease in Southeast Asia where turmeric is commonly consumed as a spice was 4.4 times lower, compared to that found in countries where the price is not as commonly used.

    Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice
    Sciencedirect.com July 2014
    Curcumin also reduced body weight gain and body fat without affecting fat distribution...However, at a high dose, curcumin suppressed development of steatohepatosis, reduced fibrotic tissue, and preserved glycogen levels in liver. Conclusion Curcumin through a series of complex mechanisms, alleviated the adverse effects of high fat diet on weight gain, fatty liver development, dyslipidemia, expression of inflammatory cytokines and atherosclerosis in Ldlr−/− mouse model of human atherosclerosis.

    5 spices to keep in your medicine cabinet
    FoxNews.com July 2014
    Curcumin, the active compound in turmeric, is what makes this spice so special and turmeric happens to be one of the only readily available, edible forms of it. A 2007 study also showed curcumin to have anticancer properties, with the potential to fight malignant diseases, diabetes, allergies, arthritis and Alzheimer’s disease.

    Evaluation of the Effect of Curcumin Capsules on Glyburide Therapy in Patients with Type-2 Diabetes Mellitus
    Phytotherapy Research July 2014
    The co-administration of curcumin capsules with glyburide may be beneficial to the patients in better glycaemic control. The lipid lowering and antidiabetic properties of the curcumin show as a potential future drug molecule.

    Antibiotic Properties Naturally Found in the Kitchen
    Globalnews.com July 2014
    Turmeric can boost immunity, helps to maintain cholesterol levels, and can even slow the process of aging.

    Research points to health benefits of turmeric
    Curcumin as an anti-cancer agent ... Clinical trials with curcumin indicate safety, tolerability, non-toxicity (even up to doses of 8,000 milligrams per day), and efficacy."
    Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate
    Nature.com June 2015
    We previously reported that curcumin has potent antifibrotic effects in vivo and in vitro, but the underlying mechanisms are not fully elucidated.
    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen
    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells...
    Research is confirming benefits of curcumin
    Among its active ingredients is curcumin, which is being actively studied for its anti-inflammatory, antioxidant, antimicrobial and cancer-fighting .
    Study: Curcumin May Help Fight Oral and Cervical Cancer
    According to Mishra, the natural antioxidant and the key ingredient of turmeric, curcumin, has the cancer-fighting properties. The research has claimed .
    Study Finds Turmeric Can Help Treat Oral Cancers
    India West May 2015
    An antioxidant present in turmeric, called curcumin, has proven effective for the treatment of the human papillomavirus. (Simon A. Eugster/Wikipedia ..
    Alternative Therapies to Prevent Diabetes
    Newsmax May 2015
    Curcumin, the substance in turmeric spice that gives Indian curry its distinctive yellow color, is an anti-inflammatory that bestows many health benefits
    The Arthritis Foundation Has Identified 9 Supplements for Arthritis Symptoms
    Curcumin supplements are very popular among arthritis patients. Curcumin is an active ingredient of the medicinal spice turmeric and is known for its ...
    Which foods are known to reduce bowel cancer risk?
    Curcumin is the substance found in turmeric that gives the spice its unmistakable yellow colour. Curcumin is a known anti-inflammatory, and it may ...
    Relieve inflammation the natural way
    Turmeric and curcumin supplements are available, though some healthcare experts recommend whole turmeric over the isolated form of curcumin.
    Turmeric Can Fight Oral And Cervical Cancer, Says Study
    The Inquisitr April 2015
    According to a study published in the journal E Cancer Medical Science, an antioxidant found in turmeric called curcumin – an active ingredient in the ...
    Circadian Responses to Chemo
    The Scientist April 2015
    Curcumin, a component of the spice turmeric, is known to have anti-cancer properties, and researchers are testing it out as a potential therapeutic ...
    Cures and curcumin -- turmeric offers potential therapy for oral cancers
    EurekAlert April 2015
    One of the herb's key active ingredients - an antioxidant called curcumin - appears to have a quelling effect on the activity of human papillomavirus ...
    Curcumin from turmeric can heal muscle injuries, reveals new study
    Scientist have found that the household curry spice curcumin, a member of the ginger family can help players recover from muscle injuries and ...
    Try turmeric today
    TV3.ie April 2015
    This is because it contains something called curcumin, which has multiple benefits. So with this in mind, we are taking a look at just some of the ways ...
    Turmeric a golden addition
    It is thought that the curcumin properties found in turmeric are responsible for the anti-inflammatory, anti-parasitic, anticancer and antiseptic abilities.
    Curry spice to overcome aches and sore muscles
    Bristol Post April 2015
    Doctors based at the Olympic Training Centre, in Barcelona, Spain, have been testing a new formulation of curcumin, a member of the ginger family ...
    MIND Protocol: Lifestyle Plan Beats Alzheimer's
    Newsmax April 2015
    "Alzheimer's is 70 percent less common in India than in the U.S., likely because of the large amounts of curcumin that are used in curries and other ...
    GRAEDONS' PHARMACY
    A: There are more than 7,500 scientific publications on curcumin, but much of the research for human health is still preliminary. Curcumin has been ...
    The Spice That May Help Fight Breast Cancer
    The Epoch Times April 2015
    Exciting new research released in the journal Clinical and Experiential Medicine found that curcumin, a naturally-occurring substance found in the ...
    Dietary curcumin may boost brain DHA: Study
    Increased intake of curcumin could boost levels of docosahexaenoic acid (DHA) in the brain by enhancing its conversion from other omega-3 ...
    One of the Best Antibiotics Could Be in Your Kitchen
    Dozens of studies have revealed many clinical benefits associated with curcumin. They include antioxidant properties, anti-inflammatory activity and protection against chronic diseases such as diabetes and cancer. The molecule also has antimicrobial activity and is effective against bacteria, viruses, and even fungi. For anyone looking for an antibiotic alternative, this particular chemical is a potential golden goose.
    Curcumin may be promising treatment for cancer
    Curcumin, a compound found in turmeric, may be a promising treatment for a variety of cancers and other inflammatory diseases, according to an ...
    The life in your spice – the health benefits of flavor
    Another star in the spice rack is turmeric, which contains curcumin, a compound now being studied for its potential to prevent cancer and Alzheimer's ...
    Spice Proves Effective Against Cancer
    Newsmax April 2015
    A new study has found that curcumin, a chemical compound found in turmeric, is a safe and promising treatment for most cancers and other ...
    Curcumin proved effective at combating cancer
    WA SCIENTISTS have helped re-affirm that curcumin, a chemical compound found in turmeric, is a safe and promising treatment for most cancers and ...

    Topical Application of Turmeric Curcumin for Cancer
    Care2.com March 2015
    In my video, Turmeric Curcumin and Colon Cancer, I talked about a study where researchers showed that, by taking curcumin, the yellow pigment in

    The Spice that Stops Muscle Pain in its Tracks
    Care2.com March 2015
    Exciting new research in the Journal of the International Society for Sports Medicine found that curcumin, one of the active ingredients in the spice ...

    Turmeric Curcumin and Colon Cancer
    Care2.com March 2015
    The low incidence of bowel cancer in India is often attributed to natural antioxidants such as curcumin, the yellow pigment in the spice turmeric, used ...
    The Spice that May Help Fight Breast Cancer
    Care2.com March 2015
    Both turmeric and curcumin supplements are readily available in most health food stores or from your natural health professional.

    4 Natural Supplements That Are as Powerful as Drugs
    EcoWatch March 2015
    Garlic and curcumin are two natural supplements that boost your immune health. ... Curcumin fights inflammation at the molecular level by blocking an ...
    Turmeric May Reduce Brain Damage, Ease Memories in Alzheimer's, PTSD
    The substance, called curcumin, may be helpful in treating Alzheimer's disease and various psychological conditions that stem from fearful memories.
    These Are The Only 3 Supplements I'll Take
    Care2.com March 2015
    Curcumin: About three years ago, I began to notice all the studies reporting the broad, well-documented potential of curcumin, the active ingredient

    Winter Depression
    Newsmax Health March 2015
    A study at Baylor University found that curcumin, the main compound in the spice turmeric, worked as well as the popular antidepressant Prozac.
    Aussie researchers trial turmeric for Alzheimer's
    6minutes March 2015
    Sydney researchers are using brain amyloid imaging to test the effects of curcumin – the active ingredient of the spice turmeric

    Expert touts disease-prevention benefits of Indian spices
    FoxNews June 2014
    Curcumin, derived from a plant that is native to the tropical southeastern Indian state of Tamil Nadu, also is used "as an adjuvant in chemotherapy, especially in breast, colon, head and neck cancer and in leukemia. Some components of curcumin are clinically shown to prevent the formation of prostate, skin and pancreas cancer cells and brain tumors.

    Five Tips To Relieve Joint Pain
    SMmirror.com June 2014
    Curcumin, is a compound known to interfere with the chemicals that cause inflammation. Multiple clinical studies have associated curcumin with anti-inflammatory and antioxidant properties. In one study, two grams of curcumin extract provided to subjects was found to provide pain relief that was equivalent to ibuprofen for pain associated with osteoarthritis of the knee.

    How What You Eat Can Help the Spinal Cord Heal Itself
    V
    alpolife.com June 2014
    DHA and curcumin appear to invoke several molecular mechanisms that preserved neurological function in the rats. This is an exciting first step toward understanding the role that diet plays in protecting the body from degenerative disease.

    Why is there Turmeric in my cereal?
    BangorDailyNews.com June 2014
    Curcumin is actually an antioxidant that has been shown to inhibit cancer cells in the laboratory, and curcumin slows the growth and spread of some cancers in some animal studies. Clinical trials are underway to see how it will benefit humans. Curcumin is being studied for its possible benefit for arthritis, Alzheimer’s disease and stomach ulcers as well as lowering bad cholesterol.

    Turmeric: Fountain of health benefits
    Greenfudge.org May 2014
    Curcumin has the ability to modulate genetic activity and expression—both by destroying cancer cells and by promoting healthy cell function. It also promotes anti-angiogenesis, meaning it helps prevent the development of additional blood supply necessary for cancer cell growth. As for its effect on molecular pathways, curcumin can affect more than 100 of them, once it gets into the cell.

    Boost Immunity
    IrishNews.com May 2014
    Curcumin, the active ingredient in turmeric. This has been found to have anti-allergy properties, which inhibit the release of histamine. Commonly used in Middle Eastern and Asian cuisine as the spice turmeric, curcumin is a phytochemical with powerful antioxidant and anti-inflammatory actions that are comparable to steroidal and nonsteroidal drugs.

    Protective effect of curcumin against heavy metals-induced liver damage
    Sciencedirect.com May 2014
    Curcumin protects against the hepatotoxicity induced by heavy metals. • Curcumin scavenges free radicals induced by heavy metals in liver. • Curcumin’s hepatoprotective effect involves the heavy metals chelation. • Curcumin promotes liver protection by upregulating the Nrf2/Keap1/ARE pathway. • Curcumin analogues or formulations improve hepatoprotection against heavy metals.

    Uncovering Hidden Secrets of an Ancient Spice
    Huffingtonpost.com May 2014
    Curcumin could provide antidepressant effects. Research on turmeric and diabetes also looks promising. Scientists have demonstrated that turmeric in the diet may be helpful in decreasing blood sugar. Traditional health uses of turmeric in India are to help wound healing and gastrointestinal symptoms. Now researchers from The University of Nottingham and Ludwig Maximilians University in Munich have found that curcumin may help reduce inflammation associated with tendinitis. Both turmeric and curcumin have shown potential to prevent DNA damage and help DNA repair. That is good news for preventing disease and slowing the aging process.

    Turmeric may reverse age associated cerebrovascular dysfunction
    examiner.com April 2014
    Curcumin is an antioxidant present in high amounts in turmeric which is the active ingredient that appears to provide turmeric with a number of potential healing abilities. A new study which has been published in the journal Cellular Physiology and Biochemistry has indicated that turmeric might provide therapeutic benefits for reversing age-related cerebrovascular dysfunction. In cerebrovascular dysfunction blood flow and circulation to the brain is impacted.

    Turmeric can inhibit cancer causing cells
    TheHindu.com April 2014
    The active ingredient in turmeric is curcumin and since second millennium BC, it is widely used in Asian medicine, food and cosmetics. In fact, medicinal uses of turmeric are well documented in folk medicine, Ayurveda and traditional Chinese and oriental medicine. It’s a fact that curcumin is therapeutic and helps in treating respiratory conditions like asthma, liver disorders, anorexia, diabetic wounds etc. It is anti-septic, anti-oxidant and anti-carcinogenic and that’s why there is a lot of interest on turmeric.Research has proved that due to curcumin there is low incidence of colon cancer and neuro-degenerative disorders such as Parkinson’s in Asians. Research has proved that curcumin can inhibit cancer causing cells or genes. The challenge now lies in delivering the right amount of curcumin to the cancer cells.

    Curcumin attenuates acute inflammatory injury

    curcumin administration may improve patient outcome by reducing acute activation of microglia/macrophages and neuronal apoptosis.

    Boost your health one cup at a time
    TampaBay.com April 2014
    Today, turmeric/curcumin research is focused on its effectiveness in fighting cancer cell growth. Breast cancer research using stem cells has shown that curcumin inhibits malignant cell formation. A study in the Asia Journal of Clinical Nutrition reported that turmeric/curcumin can protect the gallbladder and promote bile flow during detoxification from drugs, pesticides and other toxins. Curcumin and a cruciferous vegetable (cauliflower, broccoli, Brussels sprouts) make an excellent combination for removal of mercury, lead and plastic residue.

    New research reveals that turmeric may be beneficial in many health conditions, with its magic ingredient, curcumin
    Dawn.com April 2014
    ‘The Golden Wonder Herb’ is much more than that: It is a natural antiseptic and antibacterial agent, useful in disinfecting cuts and burns. Is a natural liver detoxifier. May prevent and slow the progression of Alzheimer’s disease by removing amyloyd plaque build-up in the brain. Is a potent natural anti-inflammatory that works as well as many anti-inflammatory drugs but without the side effects; it is a natural treatment for arthritis and rheumatoid arthritis. Is a natural painkiller and cox-2 inhibitor. May aid in fat metabolism and help in weight management. Has long been used in Chinese medicine as a treatment for depression. Speeds up wound healing and assists in remodelling of damaged skin. May help in the treatment of psoriasis and other inflammatory skin conditions.

    Curcumin Inhibits Prostate Cancer Bone Metastasis
    Journal of Cancer Therapy April 2014
    A number of studies have focused on the beneficial properties of Curcumin (diferuloyl methane, used in South Asian cuisine and traditional medicine) such as the chemoprevention of cancer. Recent studies have also indicated that this material has significant benefits for the treatment of cancer and is currently undergoing several clinical trials.

    Herbal supplements have anti-cancer activity

    Ocala.com March 2014
    Curcumin, one of the active compounds in turmeric spice, popular in Indian cuisine. Many studies prove curcumin slows down the growth of different types of cancer. Curcumin may be helpful for pancreatitis because it reduces inflammation in the pancreas and reduces inflammatory pain-causing chemicals. Wonderful, but you may need special IVs or supplements to get it to work.

    Using certain spices may improve health

    CapeGazette.com March 2014
    In animal studies, turmeric’s bright yellow pigment, curcumin, has been effective in preventing tumor formation. Observational studies in populations that consume large amounts of curry have strongly suggested that curcumin may help prevent cancer in the lower intestine.

    Turmeric can fight colon cancer

    Paktribune.com March 2014
    Curcumin, an active ingredient of turmeric, can fight colon cancer when used in combination with a popular anti-inflammatory drug, say researchers...Curcumin increases the anti-cancer and anti-inflammatory effects of Celecoxib while reducing its dose, thus reducing its toxic side-effects, including the rate of heart attack and stroke.

    WonderWoman.in March 2014
    "We studied the effects of curcumin on patients with major depressive disorder," says study author Ajay Goel, PhD, director of epigenetics and cancer prevention at Baylor University Medical Center. "It's possible it may help alleviate short-term mood issues, too." Curcumin inhibits the production of monoamine oxidase, an enzyme that at high levels is linked to depression.

    New Study Confirms Turmeric Can Benefit Diabetes

    GuardianLV.com March 2014
    Over a series of six months the study revealed the involvement of turmeric extract, curcumin does stop the fatty deposits forming on the inner surfaces of the arteries obstructing the blood flow...The trials results in curcumin being used without any serious unwanted effects and revealed lasting benefits for diabetes patients. Turmeric is well-known for its liver healing properties Curcumin is the active ingredient that gives turmeric its orange-yellow color. Along with related chemicals, it comprises the extraction of curcuminoid.

    Spice Up Your Health With Seasonings That Fight Diseases

    CharismaNews.com March 2014
    “Turmeric contains curcumin, which can inhibit the growth of cancer cells,” she says. “It reduces inflammation. It supports your immune system, it’s great for your liver function, and, as you know, it’s used in Indian cooking.”

    Memory-enhancing tips and supplements

    Ocala.com March 2014
    Put curcumin, the active ingredient of the common spice, turmeric, at the top of your list of Alzheimer's preventives. Seriously. Researchers have published 1,000 scientific studies on the antioxidant and anti-inflammatory properties of curcumin. A recent Japanese study showed symptom improvement for those who supplemented with turmeric capsules for one year. Two participants who had severe cases were even able to recognize family members by the study's conclusion. Back in 2008, researchers in India published a paper reviewing the major research done on curcumin as a treatment for Alzheimer's. They noted that curcumin apparently has the ability to help a component of the immune system (macrophages) clear away amyloid plaques from the brain. They concluded, “…based on the main findings above, curcumin will lead to a promising treatment for Alzheimer's.”

    Now, tumeric powder drug to help beat breast cancer

    NewsTrackIndia.com March 2014
    Curcumin, a spice used in the preparation of tumeric powder, reduced the size of tumours in mice by a third while slowing the reproduction rate of rogue cells, the Daily Express reported.

    Natural Products for Good Health

    News.am February 2014
    A study at Baylor University found that curcumin, the main compound in the spice turmeric, worked as well as the popular antidepressant Prozac. Study participants were divided into three groups: one took 500 milligrams of curcumin twice a day; the second took a standard dose of Prozac, and the third group took a combination of both. After six weeks, curcumin relieved symptoms of depression as effectively as Prozac. 

    Natural Superfoods May Help Fight Prostate Cancer

    Atlantablackstar.com February 2014
    Curcumin is a natural carotenoid and polyphenol which may be isolated from Curcuma longa or turmeric, a rhizome. Owing to their structure, carotenoids are scavengers of free radicals, which make them great anti-oxidants and boosters of the immune system of vertebrates, humans included. Curcumin is also an effective antibacterial agent and anti-carcinogenic. Studies have demonstrated that curcumin inhibits the growth of a number of tumors when used in combination with radiation therapy. In prostate cancer, curcumin overcomes the effect of prosurvival gene expression induced by the exposure of cancer cells to radiation.

    WorldBulletin.com February 2014
    The curcumin diet significantly reduced bile duct blockage and curbed liver cell damage and scarring by interfering with chemical signalling pathways involved in inflammation.

    Curcumin: A Double Hit Against Mesothelioma

    February 2014
    Curcumin, the primary component in the dietary spice turmeric, may be a powerful ally in the fight against malignant mesothelioma. The new study, published in the journal Cancer Prevention Research, finds that curcumin may both attack existing mesothelioma cells and protect against the development of new ones. Curcumin is a polyphenol with anti-inflammatory properties. Numerous studies have confirmed its ability to help fight cancer, including mesothelioma. In the newest study, a team at the University of Vermont tested curcumin on human mesothelioma cell lines as well as cells derived from infected mice.

    Fighting cancer with plant molecules: Indian scientists show the way

    TwoCircles.net January 2014
    Curcumin has been shown to be particularly beneficial in this aspect. "These phytochemicals showed their efficiency to counter DNA damage caused by arsenic. This DNA damage initiates the process of cancer development; therefore reduction of such damage may pave a way to cancer prevention. Apart from this, phytochemicals also play a role in repair of DNA damage. We conducted a field study where curcumin has been found to be of great value in combating the problem with arsenic at the genetic level."

    Six Ways Curcumin Can Help You Sleep More and Stress Less

    Huffington Post December 2013
    Take advantage of curcumin (the substance that gives turmeric it's bright yellow colour) because it can dramatically improve your health. The anti-inflammatory and antioxidant powers of curcumin prevent and fight a wide variety of conditions ranging from sleep deprivation to stress, and beyond.

    Spices, a valuable addition to a heart-healthy diet

    The Financial Express January 2014
    The benefits for heart health arise from curcumin, an active principle which is anti-oxidant, anti-clotting, anti-inflammatory and anti-proliferative. Several scientific studies have documented the effect of curcumin in decreasing blood cholesterol levels. Anti-oxidant properties of curcumin may also help prevent cardiovascular complications among diabetics.

    2013 Dec 24
    The administration of curcumin to diabetic rats normalized significantly their blood sugar level and TBARS values and increased the activities of all antioxidant enzymes and reduced glutathione concentration.

    Curcumin prevents fatty diet induced obesity, fatty liver, dyslipidemia

    FoodConsumer.org December 2013
    Curcumin has bee known to prevent Alzheimer's disease, diabetes mellitus, skin cancer, diabetic foot ulcers, triple negative breast cancer, radiation dermatitis, fluoride-induced renal injury, Parkinson's disease, colorectal cancer, and heart failure.

    Data from Affiliated Hospital Advance Knowledge in Cancer Gene Therapy

    World Journal of Gastroenterology December 2013
    Curcumin shows enhanced cytotoxicity toward PTEN-deficient cancer cells, suggesting that it might be a potential chemotherapeutic agent for cancers harboring PTEN mutations

    High Cholesterol and Clogged Arteries May be Treated Naturally with Curcumin

    Atlanta Blackstar, December 2013
    Researchers found 26 percent fewer fatty artery deposits in the mice fed the curcumin-enhanced diet. Fewer atherosclerotic lesions were seen in these mice. In addition, the researchers found that curcumin seemed to actually change the expression of genes related to plaque buildup in arteries...After 18 weeks, the researchers found that just like lovastatin, curcumin lowered blood levels of cholesterol, triglycerides and LDL cholesterol, while increasing levels of HDL (“good”) cholesterol. It also led to changes in gene expression that could be expected to reduce the risk of artery damage and heart disease.“Long-term curcumin treatment lowers plasma and hepatic cholesterol and suppresses early atherosclerotic lesions comparable to the protective effects of lovastatin,” the researchers concluded. “The anti-atherogenic effect of curcumin is mediated via multiple mechanisms including altered lipid, cholesterol and immune gene expression.”

    Curcumin prevents fatty liver

    FoodConsumer.org December 2013
    Curcumin has already been known to prevent obesity and diabetes mellitus in animal studies and human trials...Curcumin was found to suppress oleic acid induced lipid accumulation and lower triglycerides and total cholesterol levels...."These results indicated that curcumin has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability. In this report, we found curcumin exerted a regulatory effect on lipid accumulation by decreasing lipogenesis in hepatocyte. Therefore, curcumin extract may be active in the prevention of fatty liver."

    Turmeric spice trial for depression

    ioL Lifestyle December 2013
    Previous research has shown curcumin acts on a compound called brain-derived neurotrophic factor (BDNF), which helps in the development and functioning of nerve cells.

    Curcumin obliterates colon cancer cells

    NaturalNews.com December 2013
    Cancer cell death was observed through curcumin’s ability to reduce pro-caspase-3 levels, polymerase-1 cleavage and chromatin condensation. In a time- and dosage-dependent manner, curcumin caused wild-type p53 HCT-116 cells to self-destruct, while obliterating mutant p53 HT-29 cells in their tracks. The researchers were so astounded that they proposed that curcumin may actually have therapeutic potential in the management of colon cancer.

    A Grocery Bag of Beneficial Antioxidants

    HeatlhNewsDigest.com
    Curcumin is found in the spice turmeric, the main spice used to prepare curry. Curcumin is thought to have antioxidant properties, as it may decrease swelling and inflammation. Preliminary research suggests that curcumin may prevent cancer and possibly slow the spread of cancer.

    Curcumin as a regulator of epigenetic events.

    HispanicBusiness.com December 2013
    The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that enters into the composition of curry, already described for its diverse and broad biological activities, is nowadays well described as an inhibitor of DNA methyltransferase so that it is considered as a DNA hypomethylating agent...This dietary compound is able to restore the epigenetic regulation balance and appears as an attractive preventive and/or therapeutic approach against human cancer."

    Turmeric spice could benefit those with Alzheimer’s disease

    utSanDiego.com November 2013
    Some research found that curcumin may help clear the amyloid plaques found in Alzheimer's disease. Other studies documented curcumin as a powerful anti-inflammatory that may have a role in the cure of Alzheimer’s. Some research has found curcumin to be a robust antioxidant, which helps ease Alzheimer's symptoms caused by oxidation and inflammation.

    Curcumin, L-arginine and Vitamin E help diabetic foot ulcers

    Foodconsumer.org November 2013
    H.M. Maier from The Florida State University in Tallahassee, Florida, USA and colleagues reviewed studies and found evidence from animal studies indicating that curcumin, L-arginine and vitamin E as dietary supplements can help wound healing in people with type 2 diabetes mellitus.

    Science Confirms Turmeric As Effective As 14 Drugs

    ProHealth.com October 2013
    Turmeric is one the most thoroughly researched plants in existence today.  Its medicinal properties and components (primarily curcumin) have been the subject of over 5600 peer-reviewed and published biomedical studies.  In fact, our five-year long research project on this sacred plant has revealed over 600 potential preventive and therapeutic applications, as well as 175 distinct beneficial physiological effects.

    A natural alternative to antidepressants?

    FoxNews.com October 2013
    The compound curcumin is found in turmeric, a spice commonly used in the Indian curry. It’s packed with antioxidants, which help reduce inflammation and free radicals in the body, and now it may help to ease depression symptoms as well.

    Curcumin dietary supplements help fight Alzheimer's disease

    Foodconsumer.org October 2013
    Curcumin has been known to have protective effects against cancer and type 2 diabetes mellitus.  It should not be a surprise that curcumin has antidiabetic and anticancer bioactivities because it is a polyphenol that may render the protection as an antioxidant against a range of disease-associated medical conditions including tumorigenesis, oxidation, inflammation, apoptosis and hyperlipemia. In addition to Alzheimer's disease and diabetes, taking curcumin dietary supplements may help prevent or treat multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, and psoriasis, according to early studies.

    Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells.

    2013;14(6):3449-53
    Inhibitory effects of silibinin and curcumin, two herbal substances, on telomerase gene expression in breast cancer cells.

    10 Top Foods To Boost Brainpower

    Forbes.com October 2013
    Turmeric, the spice that gives curry and mustard their yellow color, contains a chemical called curcumin that’s the subject of numerous neurologic studies right now. Research has shown curcumin’s ability to boost memory, slow the progression of Alzheimer’s and stimulate neurogenesis, which is the process of creating new brain cells. Studies suggest curcumin may also clear out amyloid plaques, the brain gunk thought to be a cause of Alzheimer’s, and calm inflammation of brain and nerve cells.

    Curcumin Protects Against Lurking Dangers of Mercury Poisoning

    NaturalNews.com October 2013
    When the researchers administered daily oral curcumin treatments of 80 mg for three days, significant changes occurred. The mercury induced serum biochemical changes were reversed, as the liver and kidneys began showing signs of repair.

    Is Turmeric As Effective As Fourteen Other Drugs? Sacred Plant’s Ingredient, Curcumin, Holds Key To Health Benefits
    MedicalDaily.com October 2013
    Curcumin -- have gained attention in both the medical and media worlds, due to research that points to the herb's preventative and therapeutic qualities for diseases like arthritis, Alzheimer's and even cancer.

    Turmeric spice may have role in multiple myeloma therapy
    OncologyNurseAdvisor.com October 2013
    Curcumin, an active ingredient in the common kitchen spice turmeric, destroyed multiple myeloma cells in recent lab experiments.

    Put Some Spice in Your Life
    DocGiff.com October 5, 2013
    Researchers have tested this spice as a cure for cancer and Alzheimer’s disease. It’s actually the cause of the yellow color, curcumin in turmeric, which interests scientists. Dr. Bharat Aggarwal, professor of cancer research at the Anderson Cancer Center in Houston, said curcumin induced a programmed death of cancer cells. In addition, it suppressed formation of new blood vessels that nourished tumors. Rats, for instance, got fewer cancers of the breast and colon when given curcumin.Researchers at Harvard went a step further and injected curcumin into the bloodstream of mice with Alzheimer disease-like plaques. A week later, studies showed a 30 percent decrease in these plaques. Research into how this spice affects humans with Alzheimer’s disease is only in preliminary stages.

    No cure for Alzheimer’s disease, but curcumin may help
    Foodconsumer.org October 2013

    Epidemiological studies have shown that people who eat a diet high in curcumin were at a lower risk of Alzheimer's disease, suggesting that taking curcumin supplements may help prevent the disease. Indian studies have already suggested that a high dose of curcumin like 6 grams of curcumin per day can be used to prevent type 2 diabetes mellitus in people living with prediabetes.  Curcumin as an antioxidant has an antiinflammatory effect and may potentially help prevent a variety of cancer.

    Curcumin was a component of the spice Tumeric, and had been shown to decrease the concentration of antioxidant defence substances within a cell.

    Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo
    Cancer Gene Therapy Week October 2013
    Curcumin has strong reversal effects on the multidrug resistance of human colon carcinoma in vitro and in vivo.

    Suppository of wisdom
    Journal of Crohn's and Colitis October 2013
    Curcumin enemas may be effective in controlling disease activity in ulcerative colitis.

    Superfoods
    ThirdAge.com September 2013
    Canadian researchers reported that curcumin, found naturally in the spice turmeric, may have “antitumor activity” and “continues to receive considerable attention as a potent antioxidant and anti-cancer agent”. According to the Mayo Clinic, “At this time, there isn't enough evidence to recommend curcumin for preventing or treating cancer, but research is ongoing. Curcumin, a substance found in the spice turmeric, has long been used in Asian medicine to treat a variety of maladies. Now some research suggests that curcumin may help prevent or treat cancer.

    Antitumor activity of novel curcumin analogs in hepatocarcinoma (HepG2) cells
    Phys.org September 2013
    Curcumin, a natural polyphenol of turmeric, continues to receive considerable attention as potent antioxidant and anti-cancer agent. Numerous analogues of curcumin have been synthesized and screened for their improved biological activities.

    Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics
    Int J Oncol.
    2013 Sep
    Curcumin, the principal bioactive component in turmeric, has demonstrated versatile capabilities to modify the therapeutic efficacy of a wide range of anticancer agents...Our results show that curcumin substantially improves the pharmacokinetics of PS leading to synergistic inhibition of the growth of human lung cancer xenografts, representing a promising drug combination.

    Anti-cancer effects of docosahexaenoic acid and curcumin
    BMC Cancer
    September 2013
    The combination of DHA and CCM is potentially a dietary supplemental treatment for some breast cancers, likely dependent upon the molecular phenotype of the cancer.

    Sun-protective foods

    FoxNews.com Chris Kilham Medicine Hunter, September 01, 2013
    Turmeric root This yellow root contains a profoundly beneficial compound called curcumin that possesses superior anti-inflammatory activity, aids the immune system, enhances the brain, and protects your skin. Curcumin from turmeric is a very popular anti-inflammatory remedy. You can sprinkle turmeric on food, cook with it, or use curcumin supplements.

    Curcumin-Induced Apoptosis of Breast Cancer Cells

    Korean J Physiol Pharmacol. 2013 August
    Curcumin (diferuloylmethane), a polyphenol derived from the plant turmeric (Curcuma longa Linn), is known for its antioxidant and anti-inflammatory properties. Moreover, quite a few studies, including our own, have shown that curcumin exhibits anticancer activities against various tumors, including pancreatic, colon, ovarian, and breast cancers, by modulating multiple signaling pathways. Curcumin has been reported to increase p53 signaling, which upregulates the transcription of downstream genes such as p21 and Bax to induce apoptosis in a variety of cancer cells. In addition, curcumin causes cancer cell apoptosis, in part via suppression of Notch1 signaling.

    Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs

    Korean J Physiol Pharmacol. 2013 August
    long-term curcumin administration may reduce lung inflammation and fibrosis caused by radiation treatment.

    Effects of curcumin on glucose metabolism in the brains of rats subjected to chronic unpredictable stress

    BMC Complement Altern Med. August 2013
    Curcumin was found to ameliorate the abnormalities in the behavior and brain glucose metabolism caused by CUS, which may account for its antidepressive effects.

    Curcumin shows promise in hepatitis C

    Curcumin as effective as Prozac in treating depression, without harmful side effects, Dallas researcher says


    Curcumin can aid in many illnesses associated with inflammation, from cancer to arthritis, and even Alzheimer’s disease. Now he has a study, published in July’s Phytotherapy Research, that suggests curcumin is just as effective as Prozac, an anti-depressant fluoxetine, in treating clinical depression.

    Effects of curcumin on glucose metabolism in the brains of rats subjected to chronic unpredictable stress

    BMC Complementary and Alternative Medicine 1 August 2013
    Curcumin was found to ameliorate the abnormalities in the behavior and brain glucose metabolism caused by CUS, which may account for its antidepressive effects.

    Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.

    2013 Jul
    This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with major depressive disorder.

    “SPICE UP YOUR HEALTH” The Solid Science of Turmeric and Curcumin

    NYSE Post
    Many studies now prove that turmeric/curcumin contain over 150 potentially therapeutic traits, which include antioxidant, anti-inflammatory and anti-cancer properties. Remarkably, curcumin is capable of crossing the blood-brain barrier, which is one reason why it holds promise as a neuroprotective agent in a wide range of neurological disorders. Researchers have investigated curcumin for its potential role in improving Parkinson’s disease as well.  Studies have shown that it may even hold more promise than the drugs currently used for this disorder. 

    The Healing Powers of Curcumin

    Charles Poliquin

    The many healing properties of curcumin are some of the most exciting discoveries in the field of functional medicine. Curcumin counters inflammation, detoxifies excess estrogen, supports the body’s antioxidant system, helps deal with abnormal blood fat ratios (dyslipidemia) and offers protection against colds and flu.

    Kitchen spice as good as some prescriptions

    eMaxHealth-by Kathleen Blanchard-Jul 14, 2013
    Health benefits of curcumin in the spice turmeric include, but may not be limited to the following, based on research studies.Liver health, Heart health, Pain relief,  Colon cancer, Breast cancer prevention, Alzheimer’s disease, Obesity, Dental health, Acne,
    Depression

    Can Turmeric Relieve Pain? One Doctor's Opinion

    TIME-Jul 4, 2013
    Four in the morning, four more at night. That's eight big mustard-yellow capsules every day. They contain nothing but turmeric, a spice. But for ...

    Curcumin Provides Long-Term Protection Against Lung Damage ...

    Science World Report-Jul 3, 2013
    An interesting study on 'turmeric,' one of the key ingredient in many Asian dishes, reveals that curcumin, a naturally occurring compound in ...

    Role of curcumin in radiation therapy

    Oncology Nurse Advisor-Jul 2, 2013
    Can curcumin (the main component of turmeric) help minimize side effects related to radiation therapy
     

    Why Turmeric Might Just Be The Healthiest Spice Of All Time

    Refinery29-June 25, 2013
    Turmeric is anti-viral, anti-fungal, and anti-inflammatory. Inflammation is the root of many chronic diseases that cause our health to deteriorate — and curcumin...

    The dust mite allergy is one of the leading triggers of breathing ...

    Daily Mail-June 17, 2013
    New research shows the spice curcumin can ease symptoms in benign prostatic hyperplasia, an age-related non-cancerous condition which affects around 2.5 ...

    Find relief from those joint pains

    Times of India-by Debarati S Sen-Jun 13, 2013
    A recent research claims that curcumin, a compound of haldi, can relieve pain in ... Curcumin is the principal curcuminoid of the popular Indian spice turmeric.

    Curcumin as a regulator of epigenetic events

    Molecular Nutrition & Food Research 2013 June
    The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that enters into the composition of curry, already described for its diverse and broad biological activities...is able to restore the epigenetic regulation balance and appears as an attractive preventive and/or therapeutic approach against human cancer.

    Curcumin, Anti-Oxidant, and Pioglitazone Therapy with Inclusion of Vitamin E in Non Alcoholic Fatty Liver Disease

    Gut 2013 June
    Curcumin is a pan-antioxidant with anti-inflammatory, anti-apoptotic, anti-microbial, and anti-fibrogenic properties...This study postulates the effects of Curcumin plus vitamin E in NAFLD may prevent NASH with a modest anti-fibrotic effects and necroinflammatory score; with impressive changes in adipokines levels. Additive effects of Curcumin with vitamin E has significant effects on Serum lipids and insulin sensitivity. Unavailability of Pre and post liver biopsy was the limitation A large control trial needs to validate..

    Curcumin Shows Antiaging Potential in New Studies

    eMaxHealth-by Deborah Mitchell- June 14, 2013
    If you like curried food, then you may be fighting aging while you eat. Two new studies suggest that curcumin, the ingredient in turmeric that ...

    Breast Cancer News: Curcumin relieves radiation dermatitis

    Food Consumer-June 10, 2013
    Monday June 19, 2013 (foodconsumer.org) -- A new study in Radiation Research suggests that women who are diagnosed with breast cancer ...

    Spicing it Up with Turmeric: Health Benefits, Tips, and Recipes

    One Green Planet-June 31, 2013
    Turmeric is full of powerful antioxidants, including curcumin, which are known to fight cancer-causing free radicals. Most research done on the ...

    Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus

    Phytomedicine 2013 June
    Curcumin, a natural polyphenolic flavonoid isolated from the rhizome of a plant, Curcuma longa Linné., has been found to possess many beneficial biological activities. The aim of this study was to investigate the synergistic effect of curcumin and antibiotics as well as to determine the antibacterial activity of Curcumin against specific MRSA strains.

    Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumor cells

    J Cell Biochem. 2013 June
    Curcumin, a polyphenolic compound isolated from Curcuma longa (Turmeric) is widely used in traditional Ayurvedic medicine. Its potential therapeutic effects on a variety of diseases have long been known. Though anti-tumour effects of curcumin have been reported earlier, its mode of action and telomerase inhibitory effects are not clearly determined in brain tumour cells. In the present study, we demonstrate that curcumin binds to cell surface membrane and infiltrates into cytoplasm to initiate apoptotic events.

    Curcumin prevents obesity, diabetes and fatty liver

    Food Consumer 2013 May
    Curcumin an ingredient found in turmeric has been used to prevent many chronic diseases including obesity, type type 2 diabetes and liver disease.  Recent studies show that this dietary supplement possesses potent antioxidant, anticarcinogenic, antiinflammatory and hypoglycemic properties.

    Citrus limonoids and curcumin additively inhibit human colon cancer cells

    Food Funct. 2013 April
    This study provides compelling evidence of the pharmacodynamic additive effect of limonoids and curcumin in inhibiting human colon cancer cells. These results suggest that consumption of curcumin and limonoids together may offer greater protection against colon cancer.

    Antidepressant-Like Effects of Curcumin

    CNS Neurol Disord Drug Targets. 2013 April
    Curcumin, the major constituent of the spice turmeric produces a plethora of biological actions that have translated in vivo into behavioral and neurochemical effects in rodents that are also produced by clinically-used antidepressants.

    Curcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMPK

    Basic Clin Pharmacol Toxicol. 2013 April
    Curcumin is a well-known component of traditional turmeric (Curcuma longa), which has been reported to prevent obesity and diabetes. The levels of total cholesterol, fasting glucose and insulin in serum were decreased, and HFD-induced impairment of insulin sensitivity was improved by curcumin supplementation

    Curcumin inhibits UVB

    Exp Dermatol. 2013 April
    Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities.... Curcumin prevented UVB-induced MMP expression

    Curcumin improves spatial memory and decreases oxidative damage in aged female rats

    Biogerontology. 2013 April
    Curcumin is the active component of curcuma longa and has shown antioxidant, antiinflamatory and neuroprotective properties...curcumin supplementation improves cognitive functions by decreasing the lipid peroxidation in brain tissue of aged female rats.

    Curcumin And Curcumin-Like Molecules: From Spice To Drugs

    Curr Med Chem. 2013 April
    Curcumin is the major yellow pigment extracted from turmeric, a commonly used spice in Asian cuisine that is used extensively in ayurvedic herbal remedies. A number of studies have shown that curcumin can be a prevention agent and a chemotherapeutic agent for colon, skin, oral and intestinal cancers. Curcumin is also well-known for its anti-inflammatory and antioxidant properties, showing high reactivity towards peroxyl radicals, and thus acting as a free radical scavenger.

    Genetic And Epigenetic Studies For Determining Molecular Targets Of Natural Product Anticancer Agents

    Curr Cancer Drug Targets. 2013 April
    Accumulating evidence has demonstrated that some common natural products (such as epigallocatechin-3-gallate (EGCG), curcumin, genistein, sulforaphane (SFN) and resveratrol) have anticancer properties through the mechanisms of altering epigenetic processes and targeting cancer stem cells (CSCs). These bioactive compounds are able to revert epigenetic alterations in a variety of cancers in vitro and in vivo. They exert the anticancer effects by targeting various signaling pathways related to the initiation, progression and metastasis of cancer. It appears that natural products hold great promise for cancer prevention and treatment by altering various epigenetic modifications.

    Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin

    Mol Cell Biochem. 2013 April
    Curcumin, a phytochemical, has a wide variety of biological actions including anti-inflammatory and antioxidative....the formation of protein carbonyls in the liver of the aging mice can be prevented by the antioxidative effects of melatonin and curcumin, which may provide health benefits in aging animals.

    Curcumin inhibits invasion and metastasis in K1 papillary thyroid cancer cells

    Food Chem. 2013 April
    Curcumin, the active constituent of dietary spice turmeric, possesses a strong potential for cancer prevention and treatment...The findings showed that curcumin might be an effective tumouristatic agent for the treatment of aggressive papillary thyroid carcinomas.

    Neuroprotection by curcumin in ischemic brain injury

    PLoS One. 2013 April
    Curcumin administration significantly reduced infarct size. Curcumin also markedly reduced oxidative stress levels in middle cerebral artery occlusion (MCAO) rats; Taken together, these findings provide evidence that curcumin protects neurons against ischemic injury, and this neuroprotective effect involves the Akt/Nrf2 pathway. In addition, Nrf2 is involved in the neuroprotective effects of curcumin against oxidative damage.

    Anti-Obesity Agents Have the Potential to Inhibit Fat Gain Right at the Cellular Level

    Suppversity 2013 April
    The stimulatory effect curcumin exerts on the AMPK expression of adipocytes results in a down-regulation of PPAR-gamma in 3T3-L1 adipocytes

    Supplement Your Health With Curcumin

    Wayne County Journal Banner 2013 April
    Curcumin may have the power to ease inflammation, promote healthy cell growth, protect against ... The main bioactive compound in turmeric is called curcumin.

    Curcumin is a complete well-being tonic – it benefits every organ in the body… It shows promise of fighting nearly every disease

    Marks Daily Apple 2013 April
    Curcumin Controls Blood Sugar: It switches on the liver genes that keep glucose levels in check. It improves the pancreas’s ability to make insulin and helps slow down the metabolism of carbohydrates after meals. Curcumin Fights Cancer: It inhibits the genetic switches that allow for cancerous cell growth to occur. Curcumin Speeds Up Metabolism: USDA research shows that is enhances cellular energy to speed metabolism. Curcumin Clears Plaque: It removes amyloyd plaque buildup in the brain that can cause Alzheimer’s.

    Curcumin inhibits inflammatory response and bone loss during experimental periodontitis in rats

    2013 March
    Curcumin, an active ingredient of turmeric, is proved to be a potential candidate of controlling inflammation and bone resorption (and) may decrease alveolar bone loss in the experimental periodontitis rats via suppressing the expression of RANKL/RANK/OPG and its anti-inflammatory properties.

    Hibiscus sabdariffa linnaeus (malvaceae), curcumin and resveratrol as alternative medicinal agents against metabolic syndrome.

    2013 March
    Curcumins, derived from the spice turmeric, and resveratrol, polyphenols found in grapes and red wine respectively, in addition to their antioxidant and anti-inflammatory properties, inhibit preadipocyte proliferation, de novo lipogenesis and fat accumulation in liver....The therapeutic use of curcumin and resveratrol, in the context of obesity as an initiator of insulin resistance and hypertension, the two main features of MS, together with the underlying mechanisms of action.

    Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1

    Mol Nutr Food Res. 2013 March
    Curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) have been demonstrated as having antioxidant, anticarcinogenic, and hypocholesterolemic activities. We report the diverse antiatherogenic effects and mechanisms of curcuminoids. Curcumin was the most potent antioxidant.

    Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-kappaB activation in gastric tissues of diabetic gastroparesis rats.

    2013 March
    Curcumin is known to have antioxidant and anti-inflammatory properties. Curcumin treatment improved gastric emptying by blocking the production of oxidative stress, abolishing NF-kappaB signal transduction and enhancing expression of SCF/c-kit in rats with diabetic gastroparesis.

    Mitochondrial dysfunction mediated cisplatin induced toxicity: Modulatory role of curcumin.

    2013 March
    Curcumin is a known cytoprotectant with comprehensive anti-inflammatory and anti-cancerous properties...Curcumin should be investigated as a potential safe and remarkable approach in attenuating the adverse effects induced by CP-related toxicants.

    Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson's Disease

    2013 March
    Curcumin
    could be a candidate neuroprotective agent by inducing macroautophagy, and needs to be further investigated by clinical application in patients suffering Parkinson's disease.

    Curcumin improves expression of SCF/c-kit

    Curcumin is known to have antioxidant and anti-inflammatory properties. Curcumin treatment improved gastric emptying by blocking the production of oxidative stress, abolishing NF-kappaB signal transduction and enhancing expression of SCF/c-kit in rats with diabetic gastroparesis.

     

    Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer.

    Endocrinology Section, Department of Medicine, The University of Arizona-Feb 19, 2013
    The structural and biological importance of curcuminoids in the anti-breast cancer effects of turmeric and contradict recent assertions that certain of the curcuminoid metabolites studied here mediate these anti-cancer effects.

    Diet of curry may add health benefits

    mySteinbach.ca-February 2, 2013
    Curcumin, which provides the beautiful orange-yellow color to the turmeric root, achieves its protective quality, ...
     

    Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.

    Oncol Rep. 2013 February
    Curcumin and resveratrol are the major anticancer constituents of Curcuma aromatica and Polygonum cuspidatum, respectively. Curcumin and resveratrol have been found to exhibit a synergistic anticancer effect in colon cancer...Curcumin and resveratrol is a promising novel anticancer strategy for liver cancer. The present study also provides new insights into the effective mechanism of paired-herbs in traditional Chinese medicine.

    Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet

    J Physiol Biochem. 2013 February
    Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties...Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity.

    Integrating Dietary Supplements Into Cancer Care

    Integr Cancer Ther. 2013 February
    A list of leading supplements that have the best suggestions of benefit was constructed by leading researchers and clinicians who have experience in using these supplements. This list includes curcumin...

    Curcumin: An Orally Bioavailable Blocker of TNF and Other Pro-inflammatory Biomarkers

    Br J Pharmacol. 2013 February
    Curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable, and highly safe in humans, yet can block TNF-α action and production in in vitro models, in animal models, and in humans. In addition, we provide evidence for curcumin's activities against all of the diseases for which TNF blockers are being used.

    Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse

    Neurochem Int. 2013 February
    Curcumin emerges as a promising nutraceutical for the prevention of neurodegenerative diseases that are accompanied or caused by mitochondrial dysfunction.
     

  • Curcumin Enhances the Effect of Chemotherapy against Colorectal Cancer Cells

    Institute of Anatomy, Munich, Germany. 2013 February
    Combining Curcumin with conventional chemotherapeutic agents such as 5-FU could provide more effective treatment strategies against chemoresistant colon cancer cells

    Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF.

    Behav Brain Res. 2013 February
    Department of Pharmacology, Howard University College of Medicine
    Curcumin is the principal active ingredient found in turmeric (Curcuma longa), a plant used in traditional Asian diets and herbal medicines. It is known to have a wide range of biological actions including antidepressant-like effects which have been observed in stress-induced depression models...Evidence for an antidepressant-like effect of curcumin, possibly through increased neurotrophic activity, in the WKY model of depression, and support the notion that curcumin may prove an effective and lasting natural antidepressant.

    Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction.

    Int Immunopharmacol. 2013 February
    Curcumin, a natural polyphenolic antioxidant compound, exerts well-known anti-inflammatory and immunomodulatory effects, the latter which can influence the activation of immune cells including T cells. Furthermore, curcumin can inhibit the expression of pro-inflammatory cytokines and chemokines, through suppression of the NF-κB signaling pathway. The beneficial effects of curcumin in diseases such as arthritis, allergy, asthma, atherosclerosis, diabetes and cancer may be due to its immunomodulatory properties.

    Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice

    Pharmacol Biochem Behav. 2013 February
    Curcumin, a major active component of spic turmeric, could increase the capacity of learning and memory in the aged rat...Curcumin treatment could attenuate cognitive deficits of SAMP8 mice in a dose-dependent manner by decreasing the oxidative stress and improving the expression of p-CaMKII and p-NMDAR1 in the hippocampus. Thus treatment with curcumin may have a potential therapeutic agent for aging-related cognitive dysfunctions.

    Curcumin Inhibits UV Radiation-Induced Skin Cancer in SKH-1 Mice.

    Otolaryngol Head Neck Surg. 2013 February
    Curcumin, a naturally occurring food substance and anticarcinogenic agent, inhibited cutaneous squamous cell carcinoma xenograft growth...Curcumin appears to inhibit skin cancer formation and prolong time to tumor onset when administered by either an oral or topical route.

    Curcumin ameliorates arterial dysfunction and oxidative stress with aging.

    Exp Gerontol. 2013 February
    Curcumin supplementation ameliorates age-associated large elastic artery stiffening, vascular endothelial dysfunction, oxidative stress and increases in collagen and AGEs in mice...Curcumin may be a novel therapy for treating arterial aging in humans.

    Curcumin restores diabetes-induced neurochemical changes in the brainstem of Wistarrats.

    Eur J Pharmacol. 2013 February
    Beneficial effect of curcumin in diabetic rats by regulating the cholinergic, insulin receptor and GLUT-3 in the brainstem similar to the responses obtained with insulin therapy.

    A potent neuroprotective modulator against Alzheimer disease.

    Fundam Clin Pharmacol. 2013 February
    Some substances, such as Zn, s-Ethyl cysteine, s-propyl cysteine, citicoline, rivastigmine, Vit E, memantine, tea polyphenol, curcumin, caffeine, Alpinia galanga (L.) fractions, and Bacopa monnieri could play a role in improving memory performance and exert protective effects against Alzheimer disease.

    Complementary therapies in cystic fibrosis: nutritional supplements and herbal products.

    J Pharm Pract. 2013 February
    Complementary therapies in cystic fibrosis such as vitamin A, vitamin C, vitamin E, zinc, omega 3 fatty acids, docosahexaenoic acid (DHA), garlic, ginseng, and curcumin.

    The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer.

    March, 2013
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences
    Chemopreventive potential of a combination of aspirin (ASP), curcumin (CUR) and sulforaphane (SFN) in low doses to human pancreatic cancer cells

    Curcumin induces FasL-related apoptosis through p38 activation in human hepatocellular carcinoma Huh7 cells.

    2013 March
    Underlying molecular mechanism of curcumin-induced apoptosis in human hepatocellular carcinoma (HCC) Huh7 cells.

    Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition.

    2013 March
    The protective effects of curcumin against OSI (oxidative stress injury)
     
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  • Turmeric: sprinkle on this spice for good health

    Chiropractic Economics-Jan 11, 2013
    Curcumin, which gives turmeric its yellow color, has anti-inflammatory and ... Curcumin initiates the self-destruction of cancer cells and prevents their growth.
     
  • Spice may be new route to good health

    Palm Beach Daily News-Jan 6, 2013
    Curcumin, a phenol responsible for making turmeric yellow, does much more than provide numerous Indian dishes with that particular tint, according to Dr.
     
  • Alzheimer's and a Healthy Lifestyle

    GroundReport Jan 2, 2013
    Curcumin with its rich anti-inflammatory components. The spice is widely used in India and it's interesting to note that elderly villagers in India have one of the world's lowest rates of Alzheimer's.
     

    Turmeric Helps Conquer Arthritic Inflammation

    GreenProphet Jan 2, 2013
    This review of preclinical and clinical trials with curcumin submitted to PubMed.gov is only one of many publications attesting to its anti-inflammatory powers.

  • Rheumatoid Arthritis and Curcumin, What Studies Show

    eMaxHealth-Dec 13, 2012
    If you currently take over-the-counter or prescription medications to treat pain and other symptoms of rheumatoid arthritis (RA), you may want to consider spicing ...
  • Top Five Supplements for Women

    Scoop.co.nz-Dec 10, 2012
    Curcumin Curcumin is an extract from the curry spice, turmeric (approximately 5% of turmeric is ... Through clinical trials, curcumin has demonstrated antioxidant, ...
  • Top supplements women should not go without

    Voxy-Dec 10, 2012
    Curcumin is an extract from the curry spice, turmeric (approximately 5% of turmeric is ... Through clinical trials, curcumin has demonstrated antioxidant, ...
  • Brainy Botanicals

    Natural Products INSIDER-Dec 6, 2012
    Curcumin, the principal curcuminoid of the Indian spice turmeric, is a strong antioxidant known to fight inflammation, but other research has centered on its ability ...
  • Genistein abrogates G2 arrest induced by curcumin in p53 deficient ...

    7thSpace Interactive -Dec 1, 2012
    Methods: T47D cell line was treated with different concentrations of curcumin and genistein, alone or in combination; added together or with interval time.
  • Curcumin vs. aerobic exercise: Both promote significant & equal ...

    ProHealth-Nov 13, 2012
    We investigated the effects of curcumin ingestion and aerobic exercise training on ... women were assigned to 3 groups: control, exercise, and curcumin groups.
  • Curcumin extract for prevention of type 2 diabetes.

    Diabetes Care. 2012 Nov;35(11):2121-7.
    This study demonstrated that the curcumin intervention in a prediabetic population may be beneficial.

    Effects of curcumin on stem-like cells in human esophageal ...

    7thSpace Interactive-Nov 1, 2012
    Many cancers contain cell subpopulations that display characteristics of stem cells. Because these cancer stem cells (CSCs) appear to provide resistance to ...
  • Curcumin: An ancient remedy for cancer prevention and survival

    nwitimes.com-Oct 29, 2012
    Patients undergoing cancer treatment often look to augment their health through alternative means. Many integrative medical interventions can make a real ...
  • The effects of turmeric therapy on cerebral malaria studied

    Medical Xpress-Oct 24, 2012
    Dr Saparna Pai has been awarded an Australian Academy of Science Early-Career Australia-India Fellowship to investigate curcumin's action on immune cells ...
  • Turmeric for liver damage, cancer

    The Guardian -Oct 17, 2012
    RESEARCHERS have found that the primary polyphenol in turmeric, curcumin, is able to repair and even regenerate the liver tissues in diabetic rats.
  • Curcumin Inhibits Prostate Cancer Metastases

    Food Product Design-Oct 15, 2012
    MUNICH—Curcumin, an active component of turmeric that has been found to inhibit inflammation, may help slow down prostate cancer metastases, according to ...
  • Curcumin may be useful for cancer prevention

    Examiner.com-Oct 14, 2012
    Timothy J. Moynihan, M.D. has written for Mayo Clinic that curcumin, which is a ... Some research has suggested that curcumin may help prevent or treat cancer.
  • Prostate cancer restricted by curcumin

    allvoices-Oct 13, 2012
    The poly-phenol found in turmeric called curcumin known for its powerful ... In a new study curcumin has been shown to have a new role when it comes to ...
  • Indian curry spice 'curbs metastases'

    TruthDive-Oct 12, 2012
    Curcumin is well tolerated and is therefore, in principle, suitable both for prophylactic use and also for the suppression of metastases in cases where an ...
  • Curry treatment for Alzheimer's

    HealthCanal.com-Oct 12, 2012
    Curcumin is already known to be a powerful antioxidant and an anti-inflammatory and could combat beta amyloid, a protein responsible for Alzheimer's and ...
  • Efficacy of Herb in IBD Treatment

    Gastroenterology & Endoscopy News-Oct 11, 2012
    More research is needed to determine the efficacy of curcumin in the treatment of inflammatory bowel disease (IBD), according to a systematic review of the ...
  • Low level curcumin supplements have 'diverse' health effects

    NutraIngredients.com-Oct 5, 2012
    Curcumin, the natural pigment that gives the spice turmeric its yellow colour, has increasingly come under the scientific spotlight in recent years, with studies ...
  • Scientists trial curry chemical in dementia fight

    Radio Australia-Oct 4, 2012
    Curcumin is the compound that gives turmeric its rich yellow colour. Scientists have found it is also a powerful antioxidant, an anti-inflammatory, and may halt the ...
  • Fighting cancer starts with what's on your plate

    Dominican Today-Oct 3, 2012
    Found in turmeric, curcumin displays anti-tumor and antioxidant properties. Curcumin is a popular Indian spice that is a member of the ginger family. It's quite ...
  • Curcumin, vitamin C fight fluoride-induced renal injury

    Food Consumer-Oct 2, 2012
    The study also showed that intraperitoneal administration of curcumin at a dose of ... For the study, one week after the treatments with fluoride and curcumin, the ...
  • Curcumin Cuts Alzheimer's Risk, Heart Disease

    Food Product Design-Oct 1, 2012
    COLUMBUS, Ohio—Curcumin, a compound found the popular Indian spice turmeric may help lower inflammatory markers associated with heart disease, ...
  • Turmeric can soothe gastric inflammation, ulcers

    indiatvnews.com-Sep 23, 2012
    Curcumin is its major component responsible for the spice's yellow colour and its ... "It (curcumin) has been shown to be a good cure for gastric ailments like ...
  • Integrative Medicine: Curcumin may aid diabetes fight

    Sacramento Bee-Sep 20, 2012
    Curcumin is felt to be the primary active ingredient in turmeric. At the end of the study, none of the people who was taking the curcumin capsules had developed ...
  • Curcumin Lowers Triglycerides

    Natural Products -Sep 18, 2012
    Supplementing with 1 g/d of curcumin for 30 days led to a significant reduction in serum triglycerides, in a recent study published in ...
  • Inhibition by curcumin of multiple sites of the transforming growth ...

    7thSpace Interactive-Sep 16, 2012
    Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon ...

    Rosemary extract with curcumin fight ER-negative breast ...

    Food Consumer-Sep 5, 2012
    Additionally, carnosic acid exhibits synergy with turmeric/curcumin against breast cancer cells. These two compounds inhibited the activity of the purified ...
  • The secret recipe for longer life

    Stuff.co.nz-Sep 4, 2012
    The controversial bit comes with his inclusion of supplements like curcumin and ... Curcumin, the pigment that gives the spice turmeric it's yellow colour, is an ...
  • The anti-ageing recipe

    Sydney Morning Herald -Sep 4, 2012
    Supplements like Curcumin, the pigment that gives the spice turmeric it's yellow colour, is an anti-inflammatory, which – in animal studies - shows promise against both Alzheimer's and cancer....
  • Turmeric Improves Blood Glucose in Type 2 Diabetes

    eMaxHealth-Sep 1, 2012
    Curcumin, a major component of turmeric, is usually the ingredient people most associated with providing health benefits. In fact, curcumin has been the subject ...
     
  • Turmeric stopped deadly Rift Valley Fever

    UPI.com-Aug 24, 2012
    25 (UPI) -- Curcumin, found in turmeric, stopped the potentially deadly Rift Valley ... However, in the published article, we provide evidence that curcumin may ...
  • The healing spice: curcumin

    Emory Health Now -Aug 24, 2012
    A recent article in Chemical & Engineering News describes the promising properties of curcumin, a compound derived from turmeric, in models of Alzheimer's ...
  • Spicy solution for viral infection

    News-Medical.net-Aug 22, 2012
    Curcumin, the main compound in the spice turmeric, prevents replication of ... However, "we provide evidence that curcumin may interfere with how the virus ...
  • Curcumin Stops Rift Valley Fever Virus

    eMaxHealth-Aug 20, 2012
    The popular spice curcumin has been shown to stop the Rift Valley fever virus dead in its tracks, which may not seem highly relevant to people who don't live in ...
  • Curcumin could ultimately support drug therapies to defeat ...

    ProHealth-Aug 17, 2012
    Curcumin, a bioactive component of the popular spice turmeric, “shows ... that curcumin can stop multiplication of the potentially deadly Rift Valley Fever virus in ...
  • Curcumin found in Turmeric Spice prevented spread of Virus

    Best Syndication-Aug 16, 2012
    (Best Syndication News) - Researchers from George Mason University found that turmeric's curcumin was able to stop the deadly Rift Valley Fever virus from ...
  • Turmeric Spices Up Virus Study

    ScienceBlog.com -Aug 16, 2012
    Curcumin, found in turmeric, stopped the potentially deadly Rift Valley Fever virus from multiplying in infected cells, says Aarthi Narayanan, lead investigator on ...
  • Turmeric May Have the Key to Alzheimer's Disease

    India West-Aug 16, 2012
    Curcumin (the bioactive component of turmeric, used in day-to-day cooking and ... Studies on mice seemed to show that curcumin actually reversed a cause of ...
  • Curry Compound May Lower Diabetes Risk

    WebMD - August 2, 2012
    Small Study Suggests Curcumin May Play a Role in Diabetes Prevention ... July 31, 2012 -- Curcumin, the substance found in the spice turmeric that gives curry ...
  • Curry spice helps pre-diabetes

    Healthcare Today - August 2, 2012
    Curcumin, a compound in the spice turmeric, may help prevent diabetes in people who have pre-diabetes, according to the research, which was published in the ...
  • Curcumin And Factors That May Lower Diabetes ...

    Huffington Post - August 1, 2012
    A curry compound could help to keep diabetes at bay among people most at risk, a small new study shows. The research, published in the journal Diabetes ...
  • Curcumin, curry ingredient, helps cut diabetes risk, says study

    GlobalPost - August 1, 2012
    Curcumin, a component of curry, was found to cut the risk of type 2 diabetes in a new study. Researchers at the University of Nakomnayok in Thailand found that ...
  • Curry linked to lower risk of type 2 diabetes

    Examiner.com - July 31, 2012
    Curcumin, the spice known for giving curry dishes their very distinct flavor and color was placed under the microscope and unveiled some exciting results.
  • Curry Spice Can Help Decrease Diabetes Risk, New Study Reveals

    Foodbeat - July 13 2012
    The individuals were randomly assigned to take wither curcumin capsules or a ... The daily dosage for those taking curcumin capsules was 250 milligrams of ...
  • Curcumin May Prevent Diabetes in Prediabetes Patient

    Diets In Review - July 12 2012
    Curcumin is a compound in turmeric, a spice in the ginger family that's most commonly found in Indian cooking. According to an article in Reuters, previous lab ...
  • Curcumin Could Preserve Walking Ability Among Spinal Cord Injury ...

    Huffington Post - July 3, 2012
    A curry spice may do more than just add some flavor to your dishes -- it could also help to preserve the ability to walk in people who've had a ...
  • What is Curcumin?

    The International News Magazine - July 1, 2012
    USA 30 June 2012. What is Curcumin and why is this herb so popular? Why are the world and the medical community going gaga behind this ...

    Diet enriched with curcumin and DHA can promote neuroprotection in chronic SCI

    News-Medical.net - ‎Jun 27, 2012‎
    Researchers from the Department of Neurosurgery at the David Geffen School of Medicine and the Department of Integrative Biology and Physiology at UCLA have found that a diet enriched with docosahexaenoic acid (DHA), an omega-3 fatty acid, and curcumin ...

    DHA and curcumin help maintain neurological function after degenerative damage

    News-Medical.net - ‎Jun 27, 2012‎
    The second group consumed a standard diet supplemented with docosahexaenoic acid, or DHA, and curcumin, a compound in turmeric, an Indian curry spice. A third set of rats received a standard rat diet and served as a control group.

    Turmeric may help walking ability in spinal injuries

    New York Daily News - ‎Jun 27, 2012‎
    Washington, June 27 — A diet enriched with a popular omega-3 fatty acid and curcumin, found in Indian curry spice turmeric, preserved walking ability in rats with spinal-cord injury. The findings by researchers from the University of California Los ...

    Diet supplements can repair spinal injury?

    Times of India - ‎Jun 27, 2012‎
    WASHINGTON: A diet enriched with curcumin, a component of the popular Indian spice turmeric, and omega-3 fatty acid DHA can repair tissue damage and restore walking abilities in rats with spinal-cord injury, a new study claims.

    Curry and omega-3s might help those recovering from spinal injuries: study

    GlobalPost - ‎Jun 26, 2012‎
    Researchers at UCLA found that rats with spinal cord damage recovered faster when fed a diet rich in omega-3 compound DHA and curcumin, often found in curry. Omega-3 fatty acid-rich foods such as flax seeds (above) may help to improve walking ability ...

     

  • Turmeric boosts immune system - study

    Independent Online - 17 Jun 2012
    US research has shown that curcumin, which is found in the popular curry spice turmeric, causes a sizeable increase in a protein that boosts the immune system.
  • Curry spice turmeric may help prevent Alzheimer's disease

    Food Consumer - 11 Jun 2012
    Tuesday June 2012 (foodconsumer.org) -- A new report suggests that curcumin, a dietary polyphenol found in the curry spice turmeric may be used as a ...
  • Curry Ingredient Curcumin May Increase Protein Levels In Immune ...

    South Asia Mail - 8 Jun 2012
    The cooking spice turmeric is not only a vital ingredient in many curries, it has also been used for 2500 years as a medicinal compound in the Ayurvedic system ...
  • Drs. Oz and Roizen: Five ways to keep your brain sharp

    Kansas.com - 5 Jun 2012
    To keep your brain young, get plenty of vitamin D-3, coffee and curcumin (found in ... And if you like coffee and curcumin, these help remove brain cell poop, but ...
  • Turmeric curry to boost immunity

    Hindustan Times - 29 May 2012
    Researchers in Oregon State University in the US found that curcumin, a major ... Prof Gombart said the impact of curcumin wasn't nearly as potent as that of ...
  • Curry Fires up Immune System

    Newsmax Health - 29 May 2012
    Curcumin, found in the cooking spice turmeric, boosts the immune system's ability ... New research at Oregon State University has discovered that curcumin -- a ...
  • New role identified for compound used in ancient medicine

    domain-B - 29 May 2012
    New research has discovered that curcumin, a compound found in the cooking spice turmeric, can cause a modest but measurable increase in levels of a ...
  • Curry could help keep you fighting fit: study

    New Zealand Herald - 28 May 2012
    A new study by US researchers has found curcumin - a compound in popular curry spice, ... "Curcumin is generally consumed in the diet at fairly low levels," Prof ...
  • How Curry Spice Helps The Immune System Kill Bacteria

    Huffington Post Canada - 28 May 2012
    Curcumin is a compound found in turmeric, a flavourful, orange and yellow spice that is a key ingredient in South Asian and Middle Eastern cuisine. The spice ...
  • A curry a day might just keep the doctor at bay

    JOE - 28 May 2012
    According to the Journal of Nutritional Biochemistry, curcumin helps the body to fight ... Professor Adrian Gombart of Oregon State University said: 'Curcumin is ...
  • Curcumin Termed to be Potential Enough to Fight Infectious Diseases

    French Tribune - 28 May 2012
    It has been subjected that curcumin found in turmeric, which is spice, majorly used in South Asian and Middle Eastern cuisine, can help prevent infection.
  • Curry may boost your immune system

    Minneapolis Star Tribune   - 26 May 2012
    The researchers reported in the Journal of Nutritional Biochemistry that curcumin, a compound found in the cooking spice turmeric, can cause a modest but ...
  • Yellow makes turmeric tick

    Calcutta Telegraph - 26 May 2012
    New Delhi, May 26: Curcumin, the yellow ingredient of turmeric, increases levels of an anti-microbial protein, according to a new research study that scientists ...
  • Scientists Discover As To How a Curry Ingredient Can Help Avoid ...

    French Tribune - 26 May 2012
    It has been reported that curcumin, a major component found in turmeric, which is vastly used as a main ingredient in South Asian and Middle Eastern cuisine, ...
  • New insight into how curcumin supports the immune defense system ...

    ProHealth - 25 May 2012
    Curcumin tripled production of the CAMP peptide – the only one of its kind known in humans, and able to kill a broad range of pathogens.
  • Scientists Discover How Curry Spice Strengthens Immune ...

    Medical Daily - 25 May 2012
    Eating curry may help prevent new infections by strengthening the immune system, scientists say.
  • Delicious news: Curry might help keep you healthy

    OregonLive.com - 25 May 2012
    Researchers at OSU's Linus Pauling Institute discovered that curcumin, found in turmeric, can boost levels of cathelicidin antimicrobial peptide, a protein known ...
  • New Study Shows Some Curry Dishes Boost Immune System

    Sci-News.com - 25 May 2012
    Curcumin, a principal curcuminoid found in the popular Indian spice turmeric ... published in the Journal of Nutritional Biochemistry, suggests that curcumin, ...
  • Foods that fight cancer

    Food Consumer - 23 May 2012
    Curcumin is a major ingredient of the spice turmeric. Many studies have indicated curcumin helps prevent cancer. A number of mushrooms known as "medicinal ...
  • Natural remedies for pain relief

    SheKnows.com - 22 May 2012
    A simple, but powerful formula that includes curcumin, boswellia, DLPA, and ... Curcumin has become very popular as a supplement in the past few years.
  • Why a curry could save a life

    The Sun - 20 May 2012
    Curcumin, the yellow super-nutrient in turmeric, has health-promoting effects ... designed to see whether curcumin can work alongside chemotherapy drugs, ...
  • Benefits of Turmeric Detailed by Natural Health Sherpa

    SBWire (press release) - 18 May 2012
    Curcumin found in turmeric has several health benefits that Natural Health Sherpa ... In one study that compared the effectiveness of curcumin – the active ...
  • Can curry help fight cancer? Researchers launch trial to find out

    Cordis News - 8 May 2012
    They will investigate whether tablets containing curcumin, which is found ... This work will build on previous studies showing that curcumin can enhance the ...
  • Curry chemical's ability to fight cancer put to the test

    BBC - 7 May 2012
    Earlier studies have shown that curcumin can enhance the ability of ... "The prospect that curcumin might increase the sensitivity of cancer cells to ...
  • Researchers Looking to Test Curcumin for Bowel Cancer Treatment

    Technorati - 6 May 2012
    Researchers from UK have started working on the curry ingredient curcumin to find whether curcumin can help in increasing the therapeutic ability of ...
  • Curry's benefits in cancer prevention being studied

    CBC.ca - 5 May 2012
    A spice found in turmeric called curcumin has already been linked to a range of health benefits and previous studies have shown that it can beat cancer ...
  • Students with IV Infusions Stir Controversy

    CRIENGLISH.com - 4 May 2012
    Scientists will supplement standard chemotherapy with pills containing curcumin, a compound found in the yellow curry spice turmeric.
  • Curcumin Enhances Effect of Chemotherapy

    Visit Bulgaria - 3 May 2012
    Yet again, it has been revealed that curcumin, a compound found in turmeric, is effective in enhancing the effect of chemotherapy.
  • Curry's ability to fight cancer put to the test

    Myjoyonline.com - 2 May 2012
    Curcumin, which is found in the spice turmeric, has been linked to a range of ... Now a trial at hospitals in Leicester will investigating giving curcumin ...
  • Curry ingredient in cancer research

    Aberdeen Evening Express - 1 May 2012
    Scientists will supplement standard chemotherapy with pills containing curcumin, a compound found in the yellow curry spice turmeric.
  • Trial launched into curry chemical's cancer-fighting properties

    Medical Xpress - 28 Apr 2012
    Earlier studies have shown that curcumin can enhance the ability of chemotherapy to kill bowel cancer cells in the lab. The trial is being funded by Hope ...
  • Medics try cancer treatments

    This is Leicestershire - 27 Apr 2012
    Laboratory research has already shown curcumin can improve the ... "The prospect that curcumin might increase the sensitivity of cancer cells to ...
  • Curcumin Health Benefits Revealed

    TopNews United States - 26 Apr 2012
    However, now it is expected that the number would reduce, as a new study has been done, which has found curcumin to be quite effective in treating cancer.
  • Turmeric Component Tested For Its Ability to Treat Bowel Cancer ...

    TopNews New Zealand - 25 Apr 2012
    Many studies have proposed that chemical, Curcumin, which is present in turmeric, can be beneficiary for many health ailments. It has been exaggerated that ...
  • Curry --- A Promising Cancer-Fighter?

    Kozmedia News - 24 Apr 2012
    Curcumin, which is found in the spice turmeric, has been linked to a range of health benefits. Studies have already shown that it can beat cancer cells ...
  • Curry ingredient curcumin 'could help treat bowel cancer'

    Metro - 23 Apr 2012
    (Picture: PA) A joint Cancer Research UK and University of Leicester team is hoping to discover whether pills containing curcumin - a compound found in ...
  • Curcumin is the key

    Express.co.uk - 22 Apr 2012
    Now, patients with advanced bowel cancer are set to be give tablets packed with curcumin to discover whether it can boost the effect of more powerful, ...
  • Turmeric for obesity

    Nature.com - 20 Apr 2012
    Combined with two other kitchen essentials — pepper and onion — curcumin, the key compound of turmeric, has been shown to control these metabolic parameters ...
  • Turmeric could help in fight against diabetes

    Diabetes.co.uk - 18 Apr 2012
    Researchers have claimed that an active ingredient of turmeric called curcumin could help in the fight against obesity and diabetes, as well as excessive ...
  • Turmeric extract can lower obesity and diabetes risk: Study

    India Today - 17 Apr 2012
    Curcumin - an ingredient derived from turmeric or haldi - combined with extracts ... The combination which goes by acronym CPQ - curcumin, piperine (derived ...
  • Turmeric Extract May Lower Risk of Heart Attack after Bypass

    Medical Daily - 16 Apr 2012
    Half of the patients were given pills containing curcumin and the other half was given curcumin-free placebo pills. The pills were given three days before ...
  • Turmeric lessens risk of heart attack

    Healthcare Today - 16 Apr 2012
    Of the 121 patients, all of whom had received non-emergency bypass surgery between 2009 and 2011, half were given one gram of curcumin capsules four times a ...
  • Turmeric Might Work Wonders For the Ailing Heart

    TopNews New Zealand - 16 Apr 2012
    Curcumin has for many years now been shown to reduce inflammation and to reduce oxygen toxicity or damage caused by free radicals in a number of ...
  • Turmeric lowers heart attack risk post-surgery

    Newstrack India - 16 Apr 2012
    Curcumin, the yellow pigment found in the spice contains antioxidant and anti-inflammatory qualities. Bypass surgery improves the blood flow to the heart.
  • Curcumin shows promise in easing rheumatoid arthitis pain

    Chicago Daily Herald - 16 Apr 2012
    Today their healing potential is again being rediscovered, especially curcumin. In one recent medical study, curcumin was found to be better than ...
  • Turmeric extract may protect heart after surgery

    Chicago Tribune - 13 Apr 2012
    Half of those patients were given one-gram curcumin capsules to take four times a day, starting three days before their surgery and continuing for five days ...

    Curcumin Shows Promise for Parkinson's Disease

    PsychCentral.com - 11 Apr 2012
    By Traci Pedersen Associate News Editor Curcumin, a compound found in the spice turmeric, is able to prevent the clumping of a protein associated with ...
  • Turmeric, prostate cancer study

    Deccan Herald - 7 Apr 2012
    A study conducted in Japan on curcumin, another name for turmeric, showed positive results in ... “Curcumin is used as a supplement in Japanese food.
  • Spice Up Your Life and Fight Pain With Curcumin


     
    Everyday Health - 2 Apr 2012
    And modern-day medicine has backed up these claims with research into curcumin, the active ingredient in turmeric. Here's a recent example: At Baylor ...
  • Curcumin Holds Promise as Treatment for Brain Tumors


     
    Medscape - 29 Mar 2012
    Curcumin, a major component of the spice turmeric, has been shown to have chemopreventive and chemotherapeutic properties. Past research also demonstrates ...
  • You can spice up meals with real vitamins, nutrients


     
    Wonder Woman - 28 Mar 2012
    Diners could reach for the resveratrol or curcumin the same way as they might for salt or pepper, he said. "Once the nutraceutical is enveloped, ...
  • Turmeric Found in Diabetes Support Supplements Lowers A1C Levels ...


     
    PR Web (press release) - 27 Mar 2012
    Administration of turmeric or curcumin to diabetic rats reduced the blood sugar, ... Turmeric and curcumin supplementation also reduced the oxidative stress ...
  • Curcumin shows promise in Parkinson's disease


     
    Examiner.com - 25 Mar 2012
    Although it's premature to start taking curcumin to treat Parkinson's disease, the popular culinary compound found in the spice turmeric has shown promise ...
  • Curcumin supported greater improvement in RA disease activity ...


     
    ProHealth - 24 Mar 2012
    Curcumin is a component of the curry spice, turmeric. Recently a similar study involved osteoarthritis patients.] Curcumin is known to possess potent ...
  • Curcumin induces the apoptosis of human monocytic leukemia THP-1 ...


     
    7thSpace Interactive (press release) - 24 Mar 2012
    Curcumin is a principal compound of turmeric, commonly used to treat tumors and other diseases. However, its anti-cancer activity in human acute monocytic ...
  • Parkinson's disease may be attacked by curcumin


     
    Examiner.com - 23 Mar 2012
    Nutrition Horizon has reported "Curcumin Shows Promise in Attacking Parkinson's Disease." Michigan State University (MSU) researchers have found that ...
  • Curcumin may have Parkinson's promise: Study


     
    NutraIngredients.com - 23 Mar 2012
    Intake of the tumeric spice curcumin could help to reduce clumping of proteins associated with the onset of Parkinson's disease, according to new research.
  • 15 Vegan Superfoods You Should Be Eating Right Now


     
    Ecorazzi - 23 Mar 2012
    Curcumin, which the compound that gives turmeric its distinct color, is considered ... Dr. Oz suggests getting your daily does of curcumin via turmeric tea, ...
  • 13 Foods That Fight Allergies


     
    Care2.com - 22 Mar 2012
    The main ones include: anthocyanin, curcumin, hesperetin, and quercetin in your diet. Don't worry about remembering their names.
  • Expert Says You Can Fight Pain Naturally


     
    MyFox Detroit - 22 Mar 2012
    On Thursday, he explained the medicinal secrets of Curcumin during FOX 2 News Morning. If you'd like to meet Lemerond, he'll be at the Better Health Market ...
  • Curcumin Effective in Averting Parkinson's


     
    NewsPoint Africa - 22 Mar 2012
    As per a research, which has been published in the Journal of Biological Chemistry, it has been revealed that curcumin, an active compound found in turmeric ...
  • Curcumin nudges sluggish protein folding


     
    Futurity: Research News - 21 Mar 2012
    By bumping up the speed of protein folding, curcumin—a compound in the spice turmeric—moves it out of a dangerous speed zone allowing it to avoid clumping ...
  • Curcumin 'may treat Parkinson's disease'


     
    Netdoctor - 21 Mar 2012
    Curcumin, a compound found in the spice turmeric, may be beneficial for people with Parkinson's disease, US scientists say. About 120000 people in the UK ...
  • Turmeric compound raises new hopes for treating for Parkinson's ...


     
    Newstrack India - 21 Mar 2012
    Curcumin? has been found to be very effective in prevention of the accumulation of a ... Moreover, curcumin is an active ingredient found in spice turmeric.
  • Turmeric compound shows promise for Parkinson's treatment


     
    Newstrack India - 20 Mar 2012
    Washington, March 21 (ANI): Curcumin, a compound found in the spice turmeric, has been found to be effective at preventing clumping of a protein involved in ...
  • Curcumin Can Combat Parkinson's Disease According To New Study


     
    Doctor Tipster - 20 Mar 2012
    Curcumin, a compound of an asian spice known as turmeric, can be the next cure for Parkinson disease. It was discovered by researchers at Michigan State ...
  • Smuggling medicines in food


     
    Chemistry World - 20 Mar 2012
    To address this problem, Janaswamy and his team encapsulated curcumin molecules (a plant ... Schematic encapsulation of curcumin in the hydrocolloid matrix.
  • Is Curcumin The Pain-Free Spice Of Life?


     
    CBS - 18 Mar 2012
    Terry Lemerond is a natural health expert who believes in the power of curcumin something he calls a super spice: “It's an amazing plant, ...
  • Studies Show How Vitamin D3 Helps Clear Amyloid in AD


     
    Medscape - 15 Mar 2012
    "This new study helped clarify the key mechanisms involved, which will help us better understand the usefulness of vitamin D3 and curcumin as possible ...
  • EuroPharma Adopts Turmeric in ABC's Adopt-an-Herb Program


     
    Natural Products INSIDER - 14 Mar 2012
    EuroPharma's support ensures the latest published scientific and clinical research on turmeric and its key beneficial compound, curcumin, will be available ...
  • Curcumin, but not Prima-1, decreased tumor cell proliferation in ...


     
    UroToday - 14 Mar 2012
    Among the mediators of this effect of smoking is nuclear factor-kappa B. Curcumin suppresses cellular transformation by downregulating the activity of ...
  • Study Shows How Vitamin D Fights Alzheimer's


     
    CalorieLab Calorie Counter News - 13 Mar 2012
    Previous studies demonstrated that curcumin, an ingredient isolated from the spice turmeric, induced the same activity.
  • More Insight on Possible Role of Vitamin D Against Alzheimer's


     
    Health.com - 13 Mar 2012
    Previous research by the same University of California, Los Angeles, team found that therapy with vitamin D3 and curcumin — a chemical found in the spice ...
  • Eat yourself healthy: your dose of cancer-busting foods


     
    Mail & Guardian Online - 13 Mar 2012
    The Indian spice turmeric contains curcumin, which has been used for ... Scientific research suggests that curcumin may help to prevent or treat cancer.
  • Alzheimer's: Study Shows How The Nutrient Can Help ...


     
    Huffington Post - 12  Mar 2012
    "This new study helped clarify the key mechanisms involved, which will help us better understand the usefulness of vitamin D3 and curcumin as possible ...
  • Spice May Trigger Mesothelioma Cell Breakdown


     
    Surviving Mesothelioma - 11 Mar 2012
    A team of researchers at Keio University in Tokyo report that curcumin, the primary component in ... “Curcumin, which has a long history as a dietary spice, ...
  • Curcumin May Reduce Free Light Chains In Patients With MGUS And ...


     
    The Myeloma Beacon - 10 Mar 2012
    The Australian researchers also found that patients had reduced levels of bone breakdown while taking curcumin. “A number of the patients in this study did ...
  • Vitamin may help combat Alzheimer's Disease


     
    Examiner.com - 8 Mar 2012
    Curcumin is a chemical found in turmeric spice. Scientists believed that curcumin, like Vitamin D3, stimulated the immune system to clear amyloid beta.
  • Inflammatory Bowel Disease: Alternatives Plus Conventional Drugs ...


     
    EmpowHer - 7 Mar 2012
    Curcumin, found naturally in turmeric spice, has also been reported to have significant anti-inflammatory properties. Dr. Rebecca A. Taylor and Dr. Mandy C.
  • Alzheimer's plaques


     
    eMaxHealth - 6 Mar 2012
    "This new study helped clarify the key mechanisms involved, which will help us better understand the usefulness of vitamin D3 and curcumin as possible ...
  • Dr. Oz: Health perks you can get from spices


     
    Sarasota Herald-Tribune - 5 Mar 2012
    Dr. Mike carries a mustard pack in his pocket to get a daily dose of curcumin, the power drive in turmeric (it's what makes mustard yellow) that protects ...
  • Acupuncture & Chinese Medicine Protect Liver – New Research


     
    HealthCMI - 3 Mar 2012
    New research demonstrates that acupuncture combined with oral curcumin intake ... Researchers examined the efficacy of curcumin and acupuncture both ...
  • Find the spice of life


     
    The Idaho Statesman - 2 Mar 2012
    Dr. Mike carries a mustard pack in his pocket to get a daily dose of curcumin, the power drive in turmeric (it's what makes mustard yellow) that protects ...
     
  • Curry Spice Component May Help Slow Prostate Tumor Growth


     
    The Checkup - 20 Feb 2012
    In their study findings, researchers learned that curcumin increased the ... In addition, curcumin was found to be a strong fighter of both cell cycle and ...
  • Curry could combat Alzheimer's


     
    MSN NZ News - 19 Feb 2012
    One of the chemicals in the spice turmeric, curcumin, has been shown to prolong the life of fruit flies suffering from similar nervous disorders, ...
  • Turmeric in curry 'fights dementia'


     
    Dromore Today - 19 Feb 2012
    The study in question tested the effects of curcumin (a chemical found in the spice ... It found that curcumin improved lifespan and activity in some ...
  • Turmeric: the spice that fights dementia?


     
    Littlehampton Gazette - 17 Feb 2012
    The study in question tested the effects of curcumin (a chemical found in the spice ... It found that curcumin improved lifespan and activity in some ...
  • Turmeric can reduce Alzheimer risk, says new research


     
    thejournal.ie - 16 Feb 2012
    CURCUMIN, WHICH IS extracted from the turmeric root, could help reduce the ... The team behind the research say that curcumin has been “reported to have ...
  • Spice it up! Eating curry could stave off Alzheimer's


     
    AOL Lifestyle UK - 16 Feb 2012
    The research tested fruit flies with nervous disorders and found that those given curcumin, a chemical found in turmeric, lived 75% longer, ...
  • Curry twice a week can fight off dementia


     
    Insideireland.ie - 16 Feb 2012
    Tests carried out on fruit flies found that those given curcumin – the key ... Curcumin, extracted from the root of tumeric, has been used as medicine for ...
  • Anti-Cancer Benefits of Tumeric & Curcumin Research Results


     
    San Francisco Bay Area Today - 10 Feb 2012
    Curcumin, a natural phenol and derivative of turmeric, may be responsible for many of these effects — particularly the anti-cancer benefits.
  • Here are 10 new ways to ignite and boost your brain health, writes ...


     
    Oman Tribune - 7 Feb 2012
    Scientists are particularly intrigued by curcumin, the active ingredient in turmeric, ... Animal research shows curcumin reduces amyloid plaques and lowers ...
  • Tumeric and Curcumin Offer Powerful Anti-Cancer Health Benefits ...


     
    MarketWatch (press release) - 6 Feb 2012
    Curcumin, a natural phenol and derivative of turmeric, may be responsible for many of these effects -- particularly the anti-cancer benefits.
  • Turmeric, a natural born cancer killer


     
    Zee News - 1 Feb 2012
    New Delhi: Researchers at UCLA`s Jonsson Comprehensive Cancer Centre have found that curcumin, the main component in the spice turmeric, suppresses a ...
  • Turmeric is being used to prevent many ailments

    Innisfil Scope - 31 Jan 2012
    The active ingredient in turmeric is curcumin. The medicinal properties of this spice are constantly being discovered over the centuries.
  • The amazing health benefits of turmeric

    Mother Nature Network - 27 Jan 2012
    Doctors at UCLA recently found that curcumin, the main component in turmeric, appeared to block an enzyme that promotes the growth of head and neck cancer.
  • Protein folding lags in early Parkinson's

    Futurity: Research News - 19 Jan 2012
    ... pursuing new ways to attack Parkinson's disease, including a number of naturally occurring compounds, such as curcumin, a compound found in tumeric.
  • Health Check: Preventing Alzheimer's?

    Turn to 10.com - 13 Jan 2012
    "Curcumin is in curry powder and we're finding it's a very potent anti-inflammatory and anti-amyloid agent. So, it protects the brain," Small said.

    The Rise of Curcumin

    NewsWithViews - TOP 10 HEALTH STORIES
    Extensive research over the past five decades has indicated that curcumin reduces blood cholesterol levels; prevents low-density lipoprotein oxidation; inhibits platelet aggregation; suppresses thrombosis and myocardial infarction; suppresses symptoms associated with type II diabetes, rheumatoid arthritis, multiple sclerosis, and Alzheimer’s disease; inhibits HIV replication; suppresses tumor formation; enhances wound healing; protects against liver injury; increases bile secretion; protects against cataract formation; and protects against pulmonary toxicity and fibrosis. These divergent effects of curcumin seem to depend on its pleiotropic molecular effects, including the regulation of signal transduction pathways, and direct modulation of several enzymatic activities. Most of these signaling cascades lead to the activation of transcription factor.

  • Cancer researchers dig through spice cabinet

    New Mexico Business Weekly - 21 Dec 2011
    UNM researchers found that a compound in turmeric called curcumin could stop ... So the researchers developed a synthetic version of curcumin, which they ...
  • People's Pharmacy

    Winston-Salem Journal - 18 Dec 2011
    Two years of taking NSAIDs and other pain relievers didn't help, but I started taking curcumin capsules three days ago. I am now 50 percent pain-free, ...
  • Anti-Aging: Curry in Indian Food prevents cancers, fights alzheimers

    Canadian National Newspaper - 16 Dec 2011
    Say hello to our newest aging fighter called curcumin. ... Curcumin, a compound found in turmeric, has even been shown to help clear away the brain plaque ...
  • Curcumin Fights Fat and Improves Health

    TMR Zoo - 13 Dec 2011
    by Dominick Walsh December - 13 - 2011 A review of literature by scientists from the University of Buffalo concluded that curcumin helps regulate fat ...
  • Culinary Uses for Turmeric

    Natural Standard Blog - 12 Dec 2011
    Curcumin is the yellow-colored primary active constituent derived from turmeric and is commonly used to color foods, cosmetics and other substances. ...
  • The Super Potent Cancer-Fighting Spice

    Care2.com - 11 Dec 2011
    Curcumin – a derivative of turmeric, and the pigment that gives the ... Each 100 grams of turmeric contains an estimated three to five grams of curcumin. ...

    Low-salt diet might pose risks

    San Antonio Express - 7 Dec 2011
    Two years of NSAIDs and other pain relievers have not helped, but I started taking curcumin capsules three days ago. I am now 50 percent pain-free, ...

    Spice Nixes Pain, Inflammation, Brain Disease

    Care2.com - 2 Dec 2011
    Curcumin, the primary active ingredient in turmeric prevents the development of plaque in the brain and also has anti-pain and anti-inflammatory properties
  • Vitamin Supplement regimen to reduce weight ...


     
    Hairloss Talk - 16 Nov 2011
    Curcumin  ...
  • Healing organic plants


    Inquirer.net - Tessa R. Salazar - 7 Nov 2011
     
    The compound curcumin gives turmeric its golden yellow color. A number of recent investigations of curcumin have shown its efficacy in ...
  • Is “curcumin” a cancer and dementia treatment wonder drug?


    The Virginian-Pilot - 4 Nov 2011
     
    A member of the ginger family, curcumin is a naturally occurring chemical found in turmeric, derived from the root of the “Curcuma longa” plant native to ...
  • Valley Voice: More research


    The Desert Sun - 2 Nov 2011
     
    Curcumin: Part of the spice turmeric is prevalent in Indian foods. There are many tests using curcumin that have had successful animal and lab results in ...
  • Foods That Fight Pain


    Siliconindia.com - 24 Oct 2011
     
    Curcumin is the main therapeutic ingredient in turmeric which acts as great ... Research shows that Curcumin suppresses pain through a similar mechanism as ...
  • Study finds curcumin able to inhibit traumatic death of liver cells


    Focus Taiwan News Channel - 10 Oct 2011
     
    Taipei, Oct. 8 (CNA) Taiwanese researchers have discovered that curcumin, a compound that gives turmeric its yellow color, is effective in inhibiting liver ...
  • 17 tips for healthy hair and skin


    Times of India - 9 Oct 2011
     
    ... look for ingredients with antioxidants like vitamins C, E or a whole range of botanicals like green tea, grapeseed or pomegranate extract, curcumin, ...
  • Integrative Way: Alternative therapies show promise for ...


    Bellingham Herald - Kay Judge - Maxine Barish-Wreden - 8 Oct 2011
     
    ... including SAMe, ashwagandha, avocado/soybean unsaponifiables, boswellia, bromelain, cat's claw, curcumin (turmeric), devil's claw, ginger and willow. ...
  • Studies identify medicinal benefits from common herbs and spices


    New Zealand Herald - 7 Oct 2011
     
    Another September report by scientists at UCLA found that curcumin, ... Tests involved human volunteers eating curcumin tablets and showed that the compound ...
  • Spice Up Life With Good Health, Says TOPS


    NJ TODAY - 6 Oct 2011
     
    Turmeric, a popular spice contained in curry powder, contains curcumin. Curcumin gives turmeric its yellow pigment and may reduce the risk of cancer, ...
  • Top anti-inflammatory foods


    Fitness Goop - Claudia Pillow - 5 Oct 2011
     
    Turmeric contains curcumin which inhibits enzymes that participate in the synthesis ... The natural anti-inflammatory activity of curcumin is comparable in ...
  • Healthy Comfort Food


    Huffington Post Canada - 4 Oct 2011
     
    Turmeric contains curcumin and curcuminoids, which are powerful anti-inflammatory phytochemicals that act as natural cyclooxygenase-2 (COX-2) inhibitors in ...
  • 3 Disease-Fighting Spices


    ABC News - 3 Oct 2011
     
    Curcumin helped prevent the growth of tumors tied to colon cancer, ... "Our research found that curcumin was able to ignite the body's own tumor suppression ...
  • Extract Fights Alzheimer's


    Live in the Now - John Phillip - 2 Oct 2011
     
    In addition to a calorie restricted diet, the authors cite vitamin E, dietary polyphenols (including GSPE and resveratrol), curcumin, spices and ...
  • Spice up your life


    The National - Charles Crowell - 1 Oct 2011
     
    Last October, researchers from Saint Louis University in the US identified curcumin - a chemical contained in the curry spice turmeric - as showing promise ...
  • Eating Away Arthritis Symptoms


    KMGH Denver - 30 Sep 2011
     
    Turmeric, sometimes called curcumin, is a mustard-yellow spice from Asia. Scientific studies have shown that turmeric may help arthritis by suppressing ...
  • An Herbal Remedy for Mouth Lesions Caused by Lichen Planus


    FYI Living - Dean A. Haycock - 29 Sep 2011
     
    A review of the few research papers that describe experiments testing the effectiveness of herbs suggests that aloe vera, purslane and curcumin may have ...
  • Turmeric & Flax: Hale and hearty living


    The Express Tribune - Rayan Khan - 29 Sep 2011
     
    In its chemistry, turmeric includes curcumin, “shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal and anticancer ...
  • Managing the Adverse Effects of Nonsteroidal Anti-inflammatory Drugs


    Medscape - 28 Sep 2011
     
    Curcumin reduces indomethacin- induced damage in the rat small intestine. J. Appl. Toxicol. 27(6), 551–560 (2007). Hayllar J, Smith T, Macpherson A et al. ...
  • Spice Kills Cancer Cells, but Not Normal Cells, in Lab ...


    EmpowHer - Linda Fugate - 28 Sep 2011
     
    Studies cited by Shabbeer showed similar results for turmeric and its primary active constituent, curcumin. These results were based on cell cultures in the ...
  • A visit to the doctor


    Chicago Tribune - Joe Graedon - Teresa Graedon - 28 Sep 2011
     
    One component, curcumin, appears to be responsible. While physicians await the results of clinical trials (Cellular and Molecular Life Sciences, June 2008), ...
  • Herbs Beat Pain Drug in Study


    Fox News - Chris Kilham - 28 Sep 2011
     
    According to two of the authors of the study, Dr. B. Anthony and Dr. R. Kizhakedath, the herbal combination of curcumin derived from turmeric and boswellia ...
  • Uppers and downers


    Livemint - Vasudha Rai - 26 Sep 2011
     
    Even curcumin, an antioxidant found in turmeric, has been shown to reduce physical exhaustion in mice because of its anti-inflammatory effects. ...
  • Curcumin as "curecumin"


    Dynamic Chiropractic - David Seaman - 26 Sep 2011
     
    Curcumin as "curecumin": from kitchen to clinic. Biochem Pharmacol, 2008;75:787-809. Ozgoli G, Boli M, Moattar F. Comparison of effects of ginger, ...
  • Protect from colon cancer


    Nigerian Tribune - Sade Oguntola - 23 Sep 2011
     
    Turmeric (curcumin), which is an ingredient in Indian curry protects against cancer. Red pepper which is used widely in Nigerian cooking has been shown to ...
  • Study: Spicier Diet Could Help Fight Cancer


    Voice of America - 22 Sep 2011
     
    Much of his research focuses on curcumin, a natural substance used to make turmeric, a chief ingredient in curry sauces, which has been shown to be ...
  • Curcumin Can Suppress Head And Neck Cancer


    MedIndia - 20 Sep 2011
     
    Now researchers say that the curcumin in the spice suppresses a cell signaling pathway behind the growth of head and neck cancer. ...
  • Alzheimer's and dementia FAQ


    The Province - Elaine O'Connor - 19 Sep 2011
     
    Try spices like turmeric, as one of its components, curcumin may have some protective effects. Increase your intake of Omega-3s from sources like cold water ...
  • Chemical in spice turmeric kickstarts cancer-killing mechanisms in ...


    Imperial Valley News - Kim Irwin - 18 Sep 2011
     
    Los Angeles, California - Curcumin, the main component in the spice ... "This study shows that curcumin can work in the mouths of patients with head and ...
  • Ancient spice turmeric used in modern-day foods


    Killeen Daily Herald - Candace Mullen - 16 Sep 2011
     
    Curcumin, the active ingredient, has antioxidant properties, which some claim may be as strong as vitamins C and E. Turmeric is an ancient spice, ...
  • UCLA's Jonsson Comprehensive Cancer Center, that found that curcumin...


    UC Los Angeles - 16 Sep 2011
     
    ... professor-in-residence of head and neck surgery and a researcher at UCLA's Jonsson Comprehensive Cancer Center, that found that curcumin, the major ...
  • Study: Chewing curcumin activates cancer-killing mechanisms


    DigitalJournal.com - Elizabeth Cunningham Perkins - 15 Sep 2011
     
    Curcumin spice, made from drying and grinding turmeric plant roots into the bright, deep yellow key ingredient of curry powders, kills head and neck cancers ...
  • Cancer Growth In Head And Neck Suppressed By Turmeric


    Medical News Today - Grace Rattue - 15 Sep 2011
     
    This study shows that curcumin can work in the mouths of patients with head and ... A 2005 investigation by Wang and her team first revealed that curcumin ...
  • Fresh turmeric, kitchen or bathroom?


    Rundtownnews.co.uk - Edwin Cheeseman - 15 Sep 2011
     
    The resulting spice Turmeric and its active ingredient Curcumin are worth mentioning briefly because of the wide range of reported benefits some of which ...
  • Curcumin Breaks Up Signals That Encourage Cancer Growth


    Inventorspot - 15 Sep 2011
     
    by T Goodman The turmeric root and ground turmeric (curcumin): image via thecamreport.com A pilot study conducted by researchers at UCLA's Jonsson ...
  • Curry


    Empowered News - 15 Sep 2011
     
    The result indicates curcumin, turmeric's main component, has the ability ... There were also previous studies suggesting curcumin as an effective treatment ...
  • Curry Spice Could Be an Anti-Cancer Treatment


    Care2.com   - 14 Sep 2011
     
    by Kristina C. Curcumin, which is the main component in turmeric, a spice used in curry, can set off cancer-killing mechanisms in human saliva in people ...
  • There's a Potential Cure for Cancer in Indian Food


    The Atlantic Wire - 14 Sep 2011
     
    In a study due to be published on Thursday, researchers at UCLA's Jonsson Comprehensive Cancer Center describe how curcumin, the primary component of ...
  • Experts Applaud Turmeric for Its Health Benefits


    TopNews New Zealand - Pallavi Sharma - 14 Sep 2011
     
    "This study shows curcumin can work in the mouths of patients with head and neck malignancies and reduce activities that promote cancer growth", ...
  • The Cancer-Fighting Spice So Potent - It Even Beat Brain Tumors ...


    Food Consumer - 14 Sep 2011
     
    By Dr. Mercola Curcumin – a derivative of turmeric, and the pigment that gives the ... Most notably, curcumin is known for its potent anti-inflammatory ...
  • Turmeric, a natural born cancer killer


    Times of India - 14 Sep 2011
     
    Researchers at UCLA's Jonsson Comprehensive Cancer Centre have found that curcumin, the main component in the spice turmeric, suppresses a cell-signalling ...
  • Scholarship


    TheNewsTribune.com - 13 Sept 2011
     
    Researchers at the center were exploring the use of curcumin, a component of turmeric, to suppress the uncontrolled growth of certain cells, ...
  • Stay away, Alzheimer


    Malaysia Star - 12 Sept 2011
     
    In recent years, nutrients such as standardised water-soluble curcumin (turmeric) extracts and resveratrol have shown early promise as an anti-inflammatory ...
  • Spice up your life with these eight health superstars


    Huntington Herald Dispatch - 11 Sept 2011
     
    Like many yellow mustards (not Dijon), it's rich in turmeric, the source of cancer/arthritis/Alzheimer's-fighting curcumin. Be like Dr. Mike: Sprinkle these ...
  • Cinnamon Breaks Up Brain Plaques, May Hold Key to Fighting Alzheimer's


    Live in the Now - John Phillip - 10 Sept 2011
     
    Many natural substances including resveratrol, curcumin and blueberries have shown promise in preventing this devastating form of dementia, but no therapy ...
  • Spice up your food to spice up your health -- and your love life


    The Province - Mehmet Oz - 9 Sept 2011
     
    Like many yellow mustards (not Dijon), it's rich in turmeric, the source of cancer/arthritis/Alzheimer's-fighting curcumin. Sprinkle these seasonings on ...
  • Literatus: Curcumin precautions


    Sun.Star - Zosimo T. Literatus - 6 Sept 2011
     
    THE wonders of curcumin, the active ingredient in kitchen spice turmeric (Curcumin longa), work not only on stews but also in ...
  • Meals that Heal - Try turmeric


    The Hindu - 4 Sep 2011
     
    Curcumin, the active ingredient that gives turmeric its characteristic yellow ... In 2007, US researchers reported that curcumin helped stimulate immune ...
  • Curry spice offers hope for tendinitis pain


    The News International - 3 Sep 2011
     
    Curcumin, which gives the curry spice turmeric its bright yellow color, ... Their studies show that curcumin can be used to suppress inflammation in tendon ...
  • Food And Drink That May Prevent Alzheimer's Disease (AD)


    Sunday Leader - 3 Sep 2011
     
    The key ingredient in the curry is curcumin, a component of the spice turmeric. Curcumin appears to prevent the spread of amyloid protein plaques – thought ...
  • The Key Most Arthritis Sufferers are Not Doing Enough of


    Food Consumer - 1 Sep 2011
     
    Turmeric / curcumin: A study in the Journal of Alternative and ... This is most likely related to the anti-inflammatory effects of curcumin -- the pigment ...
  • A nutrition quiz endurance athletes — and others — can nibble on


    The Seattle Times - Sam Mcmanis - 29 Aug 2011
     
    The spice curcumin does help treat inflammatory arthritis and tendinitis, according to researchers at the University of Nottingham in ...
  • Student researchers throughout Australia compete for annual award


    News-Medical.net - 29 Aug 2011
     
    Ms Rogers' research demonstrates the ability of curcumin, an extract of the spice turmeric, to protect kidney cells from organ damage from blood flow during ...
  • Lifestyle Changes Can Bring You Closer to the Fountain of Youth


    Seattle Post Intelligencer   - 29 Aug 2011
     
    With your daily dose of these fatty acids, eat anti-inflammatory nutrients such as catechin, found in green tea and other plants, and curcumin, ...
  • Living Longer For Extra Years


    Sunday Leader - 27 Aug 2011
     
    Sprinkling curcumin powder into your favorite dishes, adds many years to your life. Most diseases are caused by chronic inflammation, and curcumin is ...
  • How to train your aging brain


    Ottawa Citizen - Julie Beun - 27 Aug 2011
     
    ... scientists are focusing on things such as vitamin C and E, Ginkgo biloba, curcumin from turmeric and caffeine. Resveratrol from red wine and dark grapes ...
  • Curcumin confirmed


    Sun.Star - Zosimo T. Literatus - 5 Aug 2011
     
    Its active ingredient is called “curcumin,” or more scientifically precise, ... A recent review of all studies on curcumin confirmed its effectiveness ...
  • Alternatively Speaking: Naturally does it


    Jerusalem Post - Natalie Marx - 4 Aug 2011
     
    The rates of Alzheimer's are much lower among the elderly in India than in the West, and early studies show that curcumin, an antioxidant phytochemical ...
  • Can Vitamin D3 in Combination with This Spice Reverse Alzheimer's ...


    Food Consumer - 3 Aug 2011
     
    Both vitamin D and curcumin, the pigment that gives spicy turmeric its yellow-orange color, ... Curcumin prevents the spread of amyloid protein plaques, ...
  • Top 100 Greatest Weight Loss Tips

    AhlanLive.com - Rue Kothari - ‎Jul 7, 2011‎
    Brightly coloured turmeric not only makes your curries taste fab, but it contains curcumin, an active ingredient that breaks down high-protein dishes, burns fat and holds back the growth of new fat tissue, according to The Journal of Nutrition. 22. ...

    Health - Recurring pain

    FM.co.za - ‎Jul 6, 2011‎
    There are several painkilling herbs, including turmeric — which contains the anti-inflammatory curcumin — and ashwaganda, used for centuries in Indian Ayurvedic medicine. In one animal study, cited in the Journal of Ethnopharmaceuticals, ...

    Fight Alzheimer's - new study

    Food Consumer - David Liu, aimee keenan-greene - ‎Jul 5, 2011‎
    Other phytochemicals that also inhibit amyloid fibril formation in vitro include resveratrol., tannic acid, curcumin, rosmarinic acid, wine related polyphenols, and epicatechin gallate, according to a review authored by Ehud Gazit and colleagues of Tel ...

    HEALING POWER OF NATURE: Simple medicines found in spices

    Sanford Herald - Christie Yerby - ‎Jul 2, 2011‎
    Turmeric (curcumin) has anti-inflammatory properties, is healthy to the liver and gallbladder, and is cancer preventative. An increasing body of scientific research is showing turmeric to be one of the most valuable medicinal spices with potent ...

    12 Indian foods that cut fat

    Times of India - Eisha Sarkar - ‎Jul 1, 2011‎
    Here are 12 foods that can help you lose weight and gain health: Turmeric : Curcumin, the active component of turmeric, is an object of research owing to its properties that suggest they may help to turn off certain genes that cause scarring and ...
  • Post-Op Pain? Try Spicy Turmeric for Relief


    FYI Living - Jo Anne Kappel - 28 Jul 2011
     
    Turmeric is an Indian spice that contains curcumin, a powerful antioxidant and ... It was recently reported that curcumin has been shown to have anti-cancer ...
  • A well-designed health plan


    Malaysia Star - 26 Jul 2011
     
    Specific foods like garlic, cruciferous greens (eg broccoli, sprouts), and green pepper and curcumin (tumeric) also enhances the detoxification pathway. ...
  • This Antioxidant Dramatically Inhibits Alzheimer's Disease Progression


    Food Consumer - 23 Jul 2011
     
    They also pointed out a potential benefit of combining ALA with other nutraceuticals like curcumin, EGCG from green tea, and docosahexaenoic acid (DHA) from ...
  • Enzyme Fights Cancer and Inflammation


    Live in the Now - John Phillip - 22 Jul 2011
     
    Similar to super nutrients such as resveratrol, curcumin and green tea extract, bromelain is a potent compound that fights cancer by dissolving unnecessary ...
  • What Common Foods May Kill Multi-Drug Resistant Cancers?


    Food Consumer - 22 Jul 2011
     
    Curcumin (turmeric) was by far the #1 food, with 26 studies attesting to its efficacy. Paprika came in at #2 with 6 studies. Cancer is, by and large, ...
  • Anti-cancer natural products isolated from Chinese medicinal herbs


    7thSpace Interactive (press release) - 21 Jul 2011
     
    These natural products are also reviewed for their therapeutic potentials, including flavonoids (gambogic acid, curcumin, wogonin and silibinin), ...
  • Areca nut and betel use


    RDH - Nancy W. Burkhart - 20 Jul 2011
     
    Other studies have suggested that both lycopene and curcumin may have benefits in precancerous lesions. The benefits of both antioxidant ability and ...
  • Can Alzheimer's Be Prevented? 5 Ways to Deter the Disease


    TakePart - Inspiration to Action - 20 Jul 2011
     
    According to a 2009 study by Professor Murali Doraiswamy, director of the Mental Fitness Laboratory at Duke University Medical Center, eating more curcumin, ...
  • Combination of dasatinib and curcumin eliminates chemo-resistant ...


    7thSpace Interactive (press release) - 20 Jul 2011
     
    The current investigation was undertaken to examine the effectiveness of the combination therapy of dasatinib (a Src inhibitor) and curcumin (a dietary ...
  • Should You Ever Take Tylenol?


    Food Consumer - 19 Jul 2011
     
    Curcumin: In a study of osteoarthritis patients, those who added 200 mg of curcumin a day to their treatment plan had reduced pain and increased mobility. ...
  • Balanced care


    Hernando Today - Jody Bowes - 14 Jul 2011
     
    In particular they say many customers ascribe to the health benefits of turmeric and curcumin, two common ingredients in curry. ...
  • 9 Sun Protective Foods


    Fox News - Chris Kilham - 14 Jul 2011
     
    This yellow root contains a profoundly beneficial compound called curcumin that possesses superior anti-inflammatory activity, aids the immune system, ...
  • Healthy Eating: 7 food wonders of the ancient world


    Jerusalem Post - Kathryn Rubin - 13 Jul 2011
     
    An active component of turmeric, curcumin is believed to be the main ... A potent anti-inflammatory, curcumin effects are even comparable to drugs, ...
  • Top Detox Foods for Summer

    becomegorgeous.com - ‎Jun 30, 2011‎
    Curcumin is the element that gives the yellowish shade to this veggie. This natural cleansing food is considered one of the most efficient remedies to eliminate toxins from the liver and the organism in general. Sprinkle a few pinches of turmeric ...

    Safe and Effective Alternative to Motrin for Arthritis

    Food Consumer - ‎Jun 27, 2011‎
    This is most likely related to the anti-inflammatory effects of curcumin -- the pigment that gives the turmeric spice its yellow-orange color. Curcumin has been shown to influence more than 700 genes, and it can inhibit both the activity and the ...

    This Powerful Herb Can Combat Cancer

    Care2.com - ‎Jun 24, 2011‎
    I've previously written about a number of different foods found to have particularly powerful epigenetic influence, such as broccoli and resveratrol, but many researchers consider the curcumin in turmeric to have the greatest potential in combating ...

    Curcumin is Key to Unlocking Cancer Epigenetic Code

    PR Newswire (press release) - ‎Jun 23, 2011‎
    In a study published in the journal Gastroenterology, entitled "Novel Evidence for Curcumin-induced DNA Methylation Changes in Colon Cancer Cells,"(1) Dr. Goel examined epigenetic expression in colon cancer cells and the influence of curcumin on cancer ...

    Curry is good for your sex life? How to really spice up your life

    Scottish Daily Record - Craig Mcqueen - ‎Jun 21, 2011‎
    Thanks to its active ingredient, curcumin, turmeric has been credited with such a wide range of health benefits that it's been called the "spice of life". Research has shown it could have an effect in stopping cancer spreading and in treating arthritis ...

    Natural healer

    Bangkok Post - ‎Jun 19, 2011‎
    This is because, curcumin, a substance found in turmeric is being studied for its possible benefits to those laid low by Alzheimer's disease, arthritis and other clinical disorders. Importantly, it may show the promise of having curable and preventive ...

    Hormel Institute gets another cancer-prevention grant

    Post-Bulletin - Jeff Hansel - ‎Jun 18, 2011‎
    The institute notes that other naturally occurring compounds are chemopreventive (or cancer-preventive), including "resveratrol" from red wine; grapes; and "curcumin" from turmeric powder. The institute, a separate entity from Hormel Foods Corp., ...

    Mount Vernon woman waging second cancer fight

    Daily Republic - Jennifer Jungwirth - ‎Jun 17, 2011‎
    She is currently on continuous low maintenance chemotherapy treatment and taking an organic supplement, curcumin, which she started in February. “I have a lot of aches and pains,” she said. “And I've shrunk in height three inches, too, ...

    Cancerous Cells Cannot Thrive Without This

    Lew Rockwell - Joseph Mercola - ‎Jun 14, 2011‎
    Not long ago, researchers at the world-renowned University of Texas MD Anderson Cancer Center published a groundbreaking scientific review of their favorite anti-cancer nutrient – curcumin. Curcumin, along with several other nutrients ...

    Nature knows best

    Maui News - Kehaulani Cerizo - ‎Jun 8, 2011‎
    The omega-3 in walnuts helps resist inflammation and balance hormones; one cup of apple juice is chock-full of vitamin C and ginger aids digestion and metabolism; eggplant has a high-quality amino acid protein profile and turmeric is high in curcumin, ...

    Chronic Pain and Inflammation: Unholy Partnership Under Fire

    EmpowHer - Jody Smith - ‎Jun 6, 2011‎
    Fish oil contains omega-3 essential fatty acids which reduce inflammation. Vitamin E and turmeric can also aid in the battle against pain and inflammation. Curcumin is the ingredient that gives turmeric its distinctive yellow-orange color. ...

    Indian Spice Rich in Antioxidants

    Opposing Views - Kate Wharmby Seldman - ‎Jun 4, 2011‎
    In addition, studies indicate that curcumin, its active ingredient, may slow certain types of cancer. It's also good as a topical treatment for sore or strained muscles, and taking it in food or in capsules can relieve inflammation associated with ...

    Men, Educate Yourself To Better Health

    Mission Times Courier - Danielle Schwaderer, Joel Detjen - ‎Jun 3, 2011‎
    Konrad L, Müller HH, Lenz C, Laubinger H, Aumüller G, Lichius JJ. Planta Med. 2000 Feb;66(1):44-7. 6. Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity. Shi Q, Shih CC, Lee KH. Anticancer Agents Med Chem. ...

    Epigenetics: effects of environment on genes

    Port Times Record - David Dunaief - ‎Jun 2, 2011‎
    Examples of dietary agents that can interfere with tumorigenesis — or the development of tumors in cancer — and activate tumor suppressor genes include spices, such as curcumin (turmeric); genistein, a polyphenol, an antioxidant, found in soybeans; ...

    Understanding the role of curcumin in Alzheimer's

    Coeur d'Alene Press - ‎Jun 1, 2011‎
    The link to diet and Alzheimer's Disease is less clearly established, but new information on curcumin (found in turmeric) may prove to be helpful. The brain is particularly vulnerable to oxidative damage due to its high rate of metabolism and ...

    Summer Must-Haves

    myfoxny.com - Brian Cashman - ‎May 31, 2011‎
    Turmeric is loaded with the antioxidant curcumin, a potent anti-inflammatory agent known to help reduce psoriasis and heal skin damaged by UV rays and other environmental factors. Vitamin C ester imparts a smooth, porcelain-like appearance. ...

    Everyday medicines

    The Union of Grass Valley - ‎May 31, 2011‎
    British immigrants from the Middle East have much lower colon cancer rates than native Brits because the turmeric in their curry-flavored food contains curcumin, which makes it difficult for cancer to grow and invade healthy tissue. ...

    Superfoods: separating fact from fiction

    Fairfield City Champion - Samantha Selinger-Morris - ‎May 30, 2011‎
    Because this underground stem is rich in phytochemicals, including beta-carotene (which helps maintain good eyesight), curcumin and salicylates, which can be used to relieve numerous ailments, including nausea, motion sickness and pain and inflammation ...
     

    Curry spice may lower head/neck chemo dose

    UPI.com - ‎May 30, 2011‎
    ANN ARBOR, Mich., May 30 (UPI) -- A compound from the Indian curry spice curcumin may reduce the needed dosage of head and neck cancer chemotherapy drugs, US researchers suggest. Senior study author Thomas Carey of the University of Michigan Medical ...

    This Common OTC Painkiller Found Linked to Cancer

    Food Consumer - ‎May 25, 2011‎
    Curcumin: In a study of osteoarthritis patients, those who added 200 mg of curcumin a day to their treatment plan had reduced pain and increased mobility. A past study also found that a turmeric extract composed of curcuminoids (plant-based nutrients ...

    Keep Cancer at Bay with These Foods

    TestCountry.com - ‎May 25, 2011‎
    Spice, spice, baby. The main ingredient in turmeric, and Indian spice, is curcumin. There are studies that indicate that curcumin has the potential to fight cancer, as it can curb changes, growth, and invasion of cancerous cells.

    15 Weight Loss Foods

    Visit - Kamelia Markova - ‎May 24, 2011‎
    The Indian spice turmeric's active ingredient curcumin helps burn fats and aids digestion by breaking down protein-rich foods, including detoxifying the liver. Cinnamon is known to significantly reduce blood glucose levels and bad cholestrol, ...

    High levels of iron and copper could possibly block DNA repair

    HealthJockey.com - ‎May 24, 2011‎
    A South Asian spice called Curcumin was one of the strongest protective agents. It also had other positive heath effects. Hegde commented that the results from Curcumin are quite beautiful. He specified that it was very effective in maintaining NEIL ...

    Fighting cancer with Turmeric?

    Toronto Sun - Richard Beliveau - ‎May 22, 2011‎
    Recent studies have suggested that these abilities could be the result of a transformation in the active compound in the spice, curcumin, by bacteria found in the intestinal flora. Turmeric is a bright yellow-coloured spice that comes from the root of ...

    Change your body, boost your metabolism and lose fat

    Ahwatukee Foothills News - ‎May 22, 2011‎
    Eliminate inflammation by choosing an anti-inflammatory diet and taking natural anti-inflammatories if necessary such as omega-3 fish oils, ginger, curcumin, L-glutamine and proteolytic enzymes. If you're eating any foods that cause inflammation, ...

    High iron, copper levels damage DNA, linked to Alzheimer's disease

    eMaxHealth - Kathleen Blanchard - ‎May 22, 2011‎
    They also found the Indian spice curcumin can help repair DNA damage from high levels of the elements that can 'free-float' in the body and cause damage . The spice binds to the metals, allowing enzymes to repair damage from reactive oxygen species. ...

    Spice Extract May Induce Death of Mesothelioma Cells

    Asbestos.com - ‎May 20, 2011‎
    Curcumin, a derivative of the spice turmeric, has come into the medical spotlight as a potential agent in treating mesothelioma. Recent in vitro and in vivo studies have investigated the turmeric-based compound's ability to induce apoptosis, ...

    Another study finds curcumin effective against cancer

    DrBicuspid.com - ‎May 20, 2011‎
    Now researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from the Indian spice curcumin can help cells overcome that resistance (Archives of Otolaryngology -- Head and Neck Surgery, May 2011, Vol. ...

    Turmeric makes head, neck cancer treatment more effective

    BioScholar News - ‎May 20, 2011‎
    Researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from curcumin helps cells overcome the treatment failure of head and neck cancer. Curcumin is the principal curcuminoid of the popular Indian spice ...

     

    Natural and Safe Anti-Inflammatory Medicines

    Fox News - Chris Kilham - ‎May 18, 2011‎
    One of the very most effective and potent natural anti-inflammatory agents is curcumin, derived from turmeric root. Turmeric is a yellow spice native to Asia, widely enjoyed as both a food and a dye. Turmeric is the yellow in curry powder, and curcumin ...

    Nothing mellow about this yellow

    Irish Independent - Rozanne Stevens - ‎May 16, 2011‎
    The yellow or orange pigment of turmeric, which is called curcumin, is even more potent. Its anti-inflammatory effects have been shown to be comparable to prescription drugs. It may provide an inexpensive, well-tolerated, and effective treatment for ...

    Diet plays a bigger role in health than imagined

    Baraboo News Republic - Brian D. Bridgeford - ‎May 16, 2011‎
    Kessenich held up a small plastic bag containing the spice tumeric and said a component of the spice, curcumin, fights inflammation. "If we cooked more with this herb, there would be a lot less inflammation in our system," he said. ...

     

  • Turmeric May Help with Alzheimer's


    Eat. Drink. Better. - Jeannie Moulton - 7 May 2011
     
    The same ingredient that gives curry its kick – curcumin – may be responsible for helping the body ward of Alzheimer's The phytochemical curcumin may help ...
  • Fresh fruit and fish 'could prevent dementia'


    Barchester Healthcare - 5 May 2011
     
    "Some research has suggested that caffeine, and various spices and herbs including curcumin, sage and lemon balm, might have a protective effect on the ...
  • Curcumin Keeps Cancer Cells at Bay


    Live in the Now - John Phillip - 3 May 2011
     
    Known as a staple in the Indian diet, the curry spice turmeric and its powerful polyphenol derivative curcumin have rapidly gained attention as a potent ...
  •  

  • The Spice that Actually Doubles as a Powerful Anti-Inflammatory


    Food Consumer - 26 Apr 2011
     
    And unlike aspirin or ibuprofen, turmeric's curcumin reduces ... Some research even suggests that curcumin may also help those suffering asthma, ...
  • Spicing up disease prevention


    Bangkok Post - 25 Apr 2011
     
    Curcumin, a key component in turmeric, is currently being evaluated by medical ... Research on curcumin has revealed it to be a potent antioxidant that can ...
  • Patients in Leicestershire are set to be the first in the country ...


    Leicester Mercury - cathy buss - 25 Apr 2011
     
    Scientists at the University of Leicester say their research shows that curcumin, an extract of the root turmeric, has the ability to kill off cancer cells ...
  • A synergistic antiproliferation effect of curcumin and ...


    7thSpace Interactive (press release) - 21 Apr 2011
     
    Docosahexaenoic acid (DHA) and curcumin (CCM) are dietary compounds known to antagonize breast cancer cell proliferation. We report that these compounds in ...
  • Curcumin-induced HDAC inhibition and attenuation of ...


    7thSpace Interactive (press release) - 18 Apr 2011
     
    In this study we evaluated the anti-cancer potential of curcumin in medulloblastoma by testing its ability to induce apoptosis and inhibit tumor growth in ...
  • Reasons to plant Turmeric


    The Island.lk  - 15 Apr 2011
     
    By itself, curcumin - the component in turmeric most often cited for its healthful effects - is a multifaceted anti-inflammatory agent, and studies of the ...
  • Watch what you eat to avoid Alzheimer's disease in old age


    Scottish Daily Record - Maria Croce - 11 Apr 2011
     
    The yellow-orange spice turmeric is packed with curcumin which reportedly ... Research says curcumin is an anti-inflammatory and antioxidant that's able to ...
  • Extending Worms' Lives, and Maybe Ours


    New York Times - Kenneth Chang - 5 Apr 2011
     
    Another compound that was successful in tests was curcumin, a bright yellow compound ... Because the dye, like curcumin, binds to the amyloid proteins, ...
  • Boost Your Metabolism, Curb Cancer, and Slash Blood Sugar with ...


    Food Consumer - 4 Apr 2011
     
    Turmeric: Its potent anti-inflammatory properties come from curcumin ... There are an estimated three to five grams of curcumin in 100 grams of turmeric. ...
  • Study by Bay Area's Buck Institute blazes trail for life span ...


    San Jose Mercury News - Richard Halstead - 3 Apr 2011
     
    One of those is curcumin, the active ingredient in the popular Indian spice turmeric. "People have been making claims about the health benefits of curcumin ...
  • Nature study shows common lab dye is a wonder drug


    EurekAlert (press release) - 3 Apr 2011
     
    Alavez said curcumin, the active ingredient in the popular Indian spice ... "People have been making claims about the health benefits of curcumin for many ...
  • Spice up your plants

    Sunday Times.lk - ‎Mar 15, 2010‎

    The pigment of turmeric (curcumin) valued for its yellow-orange colour can be used to garnish pale foods, apart from being a potent dietary antioxidant. ...

    Controlling Blood Pressure

    The Freeport News - ‎Mar 15, 2010‎

    Turmeric - a powerful East-Indian herb used in curry dishes, turmeric extract contains curcumin which is a strong anti-inflammatory. Curcumin helps lower ...

    Nutrition: Keep joint pain at bay

    BikeRadar.com - Christine Bailey - ‎Mar 15, 2010‎

    Turmeric: Turmeric contains the potent ingredient curcumin which is thought to protect against inflammation and may help relieve the pain and stiffness of ...

    Use Natural and Alternative Help for Fibromyalgia

    Natural News.com - Tony Isaacs - ‎Mar 14, 2010‎

    Curcumin, magnesium, blackseed oil (Nigella sativa) and herbal oleander extract are all powerful immune modulators which may help. ...

    Students up the ante on science projects

    The Valley Chronicle - Valerie Dew - ‎Mar 12, 2010‎

    Nilesh found that curcumin, a natural supplement that is a member of the ginger family, worked well and could possibly serve as a treatment for the disease. ...

    The Science Behind A Curry

    FemaleFirst.co.uk - ‎Mar 11, 2010‎

    Curry causes problematic stains due to the bright yellow molecule called curcumin which is found in turmeric. Turmeric can be used as a dye for clothes as ...

    Explore options for complementary approach to cancer treatment

    Charlottetown, The Guardian - Kali Simmonds - ‎Mar 10, 2010‎

    Also, there are many natural substances such as curcumin and resveratrol that are showing very promising results in treating colon and many other types of ...

    Dr. Cynara Coomer Lays Down 7 Rules to Cancer Free Life

    Vitals Spotlight - ‎Mar 4, 2010‎

    An extract in turmeric called curcumin, which gives curry its yellow color, is an amazing anti-inflammatory. I also like Vitamin D as a prevention ...

    Mixing Medications Could Leave Greater Risk of Stroke, Heart Attack

    BETTER Health Research - ‎Feb 25, 2010‎

    An alternative to Celebrex ® would be to take a nutritional supplement for arthritis and joint pain such as ginko and curcumin.

    Pharmacist - Recent studies can guide health

    StarNewsOnline.com - ‎Feb 24, 2010‎

    Curcumin can reduce the risk of Alzheimer's disease and cancer. It works even better when taken with vitamin D3. It is known also to lower blood sugar and ...

    Get energized: 3 steps to enjoying a healthy meal

    Times Herald-Record - Fran Sussman - ‎Feb 23, 2010‎

    Curcumin and turmeric have been touted as anti-inflammatory. Cinnamon may help increase metabolic function. Experiment with new flavors and see if you can ...

    Retail Contest for Date with Herb Expert

    Natural Products Marketplace - ‎Feb 22, 2010‎

    “We're delighted to sponsor the Medicine Hunter's seminar about the powerful benefits of curcumin as an immune enhancer, inflammatory response balancer, ...

    Brave new food: You won't believe the things you'll be putting in your mouth

    Lawrence Journal World - Tom King - ‎Feb 22, 2010‎

    And curcumin, a constituent of turmeric, kills cancer cells. A 2009 BBC News story about the findings of the CCRC stated that “curcumin started to kill ...

    Curry takes tastebuds on a passage to India

    The Province - ‎Feb 21, 2010‎

    The spice, and its active ingredient curcumin, also provide medicinal benefits: it acts as an antiseptic and antibacterial agent. ...

    Turmeric Effective For Weight Loss

    TopNews Arab Emirates - Kamilah Qasimi - ‎Feb 21, 2010‎

    The results of a study published in The Journal of Nutrition reveals that Curcumin, a bioactive component in Indian spice turmeric, can prove effective in ...

    curry Flavour

    Irish Independent - Susan Jane - ‎Feb 20, 2010‎

    Its rich curcumin content is applauded for decreasing irritability in the bowels, lowering LDL cholesterol and fighting cancer by counteracting oxidative ...

    UAE gets Dh400,000 for cancer research

    Middle East North Africa Financial Network - ‎Feb 18, 2010‎

    The research projects include the 'characterisation of curcumin signal transduction and apostosis as possible target for chemotherapy' and the 'novel ...

    Curcumin And Multiple Myeloma: Preclinical And Early Clinical Studies Are ...

    The Myeloma Beacon - Francie Diep - ‎Feb 17, 2010‎

    Curcumin has been garnering increased attention as a potential anticancer treatment. It is the major active compound in turmeric, a popular Indian spice ...

    Turmeric - a new way to spice up your weight loss routine

    Oneindia - ‎Feb 16, 2010‎

    17 (ANI): Curcumin, a bioactive component in Indian spice turmeric, can prove effective if added in weight loss routine, a new study suggests. ...

    Turmeric's Compound Can Spice Up Your Weight Loss Routine!

    TopNews - Piyush Diwan - ‎Feb 16, 2010‎

    Curcumin, a bioactive constituent in turmeric, can prove effectual if added in weight loss schedule, a new research has suggested. ...

     Research teams awarded over $1 mil. in grants

    The Brown Daily Herald - Rebecca Ballhaus - ‎Feb 15, 2010‎

    Curcumin is an “active component” in the spice's effect on cancer cells, but it is scarce in nature, he said. “Our goal is to determine whether there are ...

    Naturally Reduce Your Chances of Getting Cancer, Part I

    Natural News.com - Tony Isaacs - ‎Feb 13, 2010‎

    (NaturalNews) Mainstream health experts have estimated that up to 40% of all cancer could be prevented with more immunizations against diseases that ...

    Naturally Reduce Your Chances of Getting Cancer, Part II

    Natural News.com - Tony Isaacs - ‎Feb 13, 2010‎

    Curcumin protects against a wide range of cancers including lung and colorectal cancers. Studies have found that curcumin is especially beneficial for those ...

    Herbal magic

    Times of India - Sanaya Chavda - ‎Feb 13, 2010‎

    Recently, turmeric powder was in the news for evidence that it contains curcumin which can fight Alzheimer's and Dementia, as well as for having anti-cancer ...

    Nutrition Tidbits to Live By

    Natural Products Marketplace - ‎Feb 12, 2010‎

    Spicy Brain Food: Curcumin works to reduce the risk of Alzheimer's disease, and taking it with vitamin D3 may enhance the effects. ...

    Fight Tumor Re-Seeding with Natural Remedies

    Natural News.com - Luella May - Feb 12, 2010‎

    Curcumin is another highly proven cancer fighter and preventative. Black Cumin Oil (Nigella Sativa) has been highly revered throughout history. ...

    A potpourri of information from the pharmacist

    Herald & Review - ‎Feb 9, 2010‎

    Curcumin can reduce the risk of Alzheimer's disease and cancer. It works even better when taken with vitamin D3. Speaking of curcumin, it is known to lower ...

    Fit Tip Tuesday!

    Albany Times Union (blog) - Carin Lane - ‎Feb 9, 2010‎

    Turmeric, also known as Curcumin, is a raw vegetable that's similar to ginger. It's full of antioxidants that keep your brain cells from dying. ...

    Medical miracles march on

    Muse - ‎Feb 1, 2010‎

    A study at the Cork Cancer Research Centre showed that curcumin, which is a chemical found in the spice turmeric, rapidly killed laboratory cancer cells. ...

    The thighs have it

    Toronto Star - ‎Jan 29, 2010‎

    The reason: It's thought to be the curcumin- derivative turmeric found in curry (and inexpensive mustards). Savour a little chocolate. ...

    Turmeric Treats Candida Infection and Colorectal Cancers

    Natural News.com - Melanie Grimes - ‎Jan 27, 2010‎

    Known by its Latin name, curcumin, turmeric shows promise as an antifungal for Candida as well as many other fungal infections. According to the Journal of ...

    Food and drink: Remember to… to…

    Pique newsmagazine - Glenda Bartosh - ‎Jan 27, 2010‎

    And research points to curcumin as being one of the roots of that. Curcumin is the phytochemical that gives turmeric powder its distinctive bright ...

    Detox

    Irish Independent - ‎Jan 25, 2010‎

    Turmeric's curcumin compound has long been celebrated in Asian cuisine and Ayurveda medicine for its anti-inflammatory, antiseptic and antioxidant power. ...

    How plant derivatives offer protection against aflatoxin

    The Guardian - Nigeria - Chukwuma Muanya - ‎Jan 20, 2010‎

    Meanwhile, University of Missouri, United States, researchers have found that curcumin, a popular Indian spice derived from the turmeric root, could reduce ...

    Turmeric curry spice

    Public Service - ‎Jan 20, 2010‎

    The chemical curcumin found in the curry spice turmeric destroys gullet cancer cells in the lab, scientists at the Cork Cancer Research Centre have found. ...

    Cooking with anti cancer herbs and spices better than some medicines

    eMaxHealth - Kathleen Blanchard - ‎Jan 19, 2010‎

    Curcumin from turmeric has been extensively studied for its anti cancer properties, specifically by Bharat B. Aggarwal, PhD., professor of experimental ...

    Curry spice 'kills cancer cells'

    Pak Watan - ‎Jan 19, 2010‎

    The chemical - curcumin - has long been thought to have healing powers and is already being tested as a treatment for arthritis and even dementia. ...

    Deliver Nutrition and Taste in a Convenient One-pot Meal

    Kansas City infoZine - ‎Jan 17, 2010‎

    The powerful spice's active ingredient is curcumin, an antioxidant with anti-inflammatory properties. Some studies indicate that curcumin may slow the ...

    One Spice

    Gather.com - ‎Jan 15, 2010‎

    Scientists and all those famous "old wives" have long thought that the chemical, which is called curcumin, has healing powers for everything from arthritis ...

    20 great foods you aren't eating

    Times Online - ‎Jan 15, 2010‎

    As used liberally in Gordon Ramsay's recipes, this is a great source of curcumin, which is believed to have anti-inflammatory effects and may help to fight ...

    Curry Spice May Fight Alzheimer's Disease

    Online - International News Network - Jan 7, 2010

    For centuries, doctors practicing traditional Indian medicine have safely prescribed curcumin in extract form for a variety of illnesses and ailments. ...

    Spices May Prevent Tumor Growth

    GlamScene - Jan 6, 2010

    The study, posted online in the journal Breast Cancer Research and Treatment, indicated that the finding of curcumin (from turmeric) and piperine (from ...

    Turmeric (Curcumin) for Inflammatory Conditions

    EmpowHer - ‎Jan 5, 2010‎

    Currently, there are 37 clinical trials in progress in the United States evaluating its active ingredient, curcumin, for inflammatory conditions and other ...

    COX-2 Inhibitor May Ease Skin Cancer Burden

    MedPage Today - Crystal Phend - ‎Jan 5, 2010‎

    Another possibility is development of several plant-derived small molecules, such as honokiol and curcumin, that have been shown to inhibit COX without ...

    Yellow magic of turmeric

    Inquirer.net - Amy Cavosora - ‎Jan 4, 2010‎

    Modern research has uncovered more benefits to the spice, particularly its active ingredient, curcumin. Just like most spices, it is naturally antimicrobial ...

    Interview With Dr. Mark Petrash, Leading Aldose Reductase Researcher

    A Sweet Life - Robert Scheinman - ‎Jan 1, 2010‎

    Curcumin is another spice that is used in Indian cooking. We just published a paper with Dr. Reddy's lab, showing that that curcumin, which is known to ...

    Nutrition to Prevent Cataracts

    EmpowHer - ‎Dec 30, 2009‎

    Curcumin, from the spice turmeric which is commonly used in Indian food; 8. Resveratrol, found in grapes and sold as a dietary supplement; 9. ...

    Making Love in the Kitchen: Spice Up Your Immune System... with Spicey Dal

    National Post (blog) - Meghan Telpner - ‎Dec 30, 2009‎

    In addition to being a holy smokes anti-inflammatory, curcumin is also rich in anti-oxidants and helps detoxify the liver. And it gives curries that ...

    Scientists find turmeric spices

    Natural News.com - Sl Baker - ‎Dec 29, 2009‎

    Researchers at the University of Michigan (UM) Comprehensive Cancer Center have found that the compounds curcumin, which is derived from turmeric, ...

    The spice of life

    7DAYS - ‎Dec 27, 2009‎

    Curcumin's medicinal properties are now also thought to be able to protect liver and kidney function, ward off Alzheimer's disease and even kill cancer ...

    Flu, holidays don't mix

    Indianapolis Star - ‎Dec 23, 2009‎

    They reached this conclusion when the dietary compounds curcumin, derived from the Indian spice turmeric, and piperine, derived from black peppercorns, ...

    Curcumin May Fight Breast Cancer

    About - News & Issues (blog) - ‎Dec 22, 2009‎

    A combination of curcumin (a compound found in the curry spice turmeric) and piperine (a substances derived from black peppers) could help protect against ...

    Have Yourself a Merry Little Curry

    Psychology Today (blog) - Shirah Vollmer - ‎Dec 21, 2009‎

    Dr. Cummings is one of the authors in a study published in 2005 which says that there is a potential role for the curry spice curcumin (turmeric) in the ...

    If You Haven't Tried Turmeric, You Should

    Tonic - Jac Chebatoris - ‎Dec 19, 2009‎

    Turmeric contains curcumin, which is the potent substance that targets and attacks cancer cells, while leaving normal cells well enough alone. ...

    Mixing Medications Could Leave Greater Risk of Stroke, Heart Attack

    BETTER Health Research - Donna Parker - ‎Dec 18, 2009‎

    An alternative to Celebrex would be to take a nutritional supplement for arthritis and joint pain such as ginko and curcumin.

    Holiday Cheer: The Good, the Bad and the Ugly

    Huffington Post (blog) - ‎Dec 18, 2009‎

    Alcohol is detoxified by the liver; therefore, another highly recommended strategy to protect the liver is to use curcumin, the substance that gives the ...

    Scientists at St. Louis University, Department of Pathology report research in ...

    Behavioral Health Central (blog) - ‎Dec 17, 2009‎

    A new study, 'Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating ...

    10 Ways to Improve Your Cholesterol Panel Without Drugs

    Stop Aging Now - Peggy L. Manuel - ‎Dec 17, 2009‎

    Raise HDL with niacin (nicotinic acid), dark chocolate (minimum 70% cocoa mass), curcumin (extract of turmeric), kale (juiced) or hibiscus tea. ...

    Haldi Zapping

    Reading Little India - ‎Dec 16, 2009‎

    A study in the British Journal of Cancer reports that curcumin, the compound in turmeric, kills cancer cells within 24 hours. Principal researcher Dr Sharon ...

    Spices May Prevent Breast Cancer

    WebMD - Kelli Miller Stacy - ‎Dec 15, 2009‎

    Researchers at the University of Michigan Comprehensive Cancer Center applied piperine, found in black pepper, and curcumin, the main ingredient in the ...

    Curcumin Holds Promise as Anti-Cancer Agent for Prevention and Treatment of ...

    Alternative Health Journal (blog) - Derrick DeSilva Jr. - ‎Dec 14, 2009‎

    Effects of curcumin treatment on the cell lines included: mitotic catastrophe, autophagy, accumulation of poly-ubiquitinated proteins and cyclin B ...

    Long live the greens

    Irish Times - ‎Dec 14, 2009‎

    A study carried out at University College Cork recently captured headlines when the researchers showed that curcumin, a component of the spice turmeric, ...

    Nature's cure

    Express Buzz - ‎Dec 13, 2009‎

    The project, which includes clinical trials using a drug made from 'curcumin', a component found in turmeric, will test the medicine on 210 patients who are ...

    Spice Compounds May Stem Tumor Growth

    U.S. News & World Report - ‎Dec 11, 2009‎

    When curcumin (from turmeric) and piperine (from black peppers) were applied to breast cells in the laboratory, the number of stem cells decreased, ...

    Herbs and spices can be good -- and good for you

    Wisconsin State Journal - Dec 5, 2009

    New studies suggest that curcumin, the bright yellow compound in turmeric, may help inhibit cancer cells, reduce inflammation and safeguard the brain, ...

    Curry tablets may help fight disease

    Dr. Cutler - ‎Dec 2, 2009‎

    The ingredient, curcumin, is a potent antioxidant found in the turmeric spice that is currently being tested for its safety and effectiveness for fighting ...

    Brain food

    AsiaOne - Audrey Ho - ‎Dec 1, 2009‎

    Interestingly, the curry spice curcumin has also been shown to 'reduce memory deficits in animal models of Alzheimer's disease and brain trauma'. ...

     

    Enigmatic viral promotion

    spectroscopyNOW.com - ‎Nov 30, 2009‎

    They are also planning to screen a range of antioxidant compounds, such as green tea extract, curcumin (from the spice turmeric), and resveratrol (from red ...

    An apple a day could keep cancer away

    eMaxHealth - Kathleen Blanchard - ‎Nov 27, 2009‎

    The protein, kappa B (NF-KB), was blocked by apple extract and curcumin. Resveratrol was also studied, but did not produce the same results. ...

    Curcumin from turmeric has anti-malarial properties: IISc

    Daily News & Analysis - ‎Nov 27, 2009‎

    PTI Hyderabad: A new research at the Indian Institute of Sciences (IIsc) in Bangalore has found that a drug combined with curcumin from turmeric can prove ...

    Take These Natural Measures to Prevent and Treat Gallstones

    The Healthier Life - ‎Nov 25, 2009‎

    Take 300mg of curcumin (an active component of the yellow spice turmeric) three times a day to increase the solubility of your bile. ...

    Gunawan T. : The spice of life

    Jakarta Post - ‎Nov 24, 2009‎

    He found the trend was for curcumin – an ingredient found in turmeric, a ginger-family plant native to India and Southeast Asian countries. ...

    How to Slow Aging and Prevent Alzheimer's

    Natural News.com - Paul Fassa - ‎Nov 23, 2009‎

    Curcumin minimizes or eliminates plaque and inflammation. Vitamin B12 with folic acid and B6 are good for brain health too. Hosphatidyl serine supplements ...

    Experts share views on cancer treatment

    Times of India - ‎Nov 22, 2009‎

    Dr Krishna Misra from Indo-Russian Centre for Biotechnology, IIIT spoke on "The application of curcumin and some of its conjugates as anti-tumour agents. ...

    Women2Day - Health: The spice of life

    Flintshire Chronicle - Chester Chronicle - ‎Nov 22, 2009‎

    Curcumin's medicinal properties are now also thought to be able to protect liver and kidney function, ward off Alzheimer's disease and even kill cancer ...

    An Atomic-Level Look at an HIV Accomplice

    Science Daily - ‎Nov 20, 2009‎

    They also plan to screen antioxidant compounds such as green tea extract, curcumin and resveratrol (found in red wine) to see if such compounds are capable ...

    Cosmetics - A little history and a whole lot of super beauty tips and advice!

    DSO Maghreb - ‎Nov 18, 2009‎

    Curcumin may spice up your regimen for disease prevention, longevity and healthy skin. When your skin is tight, it's crying out for moisture. ...

    To fight inflammation with food

    Los Angeles Times - ‎Nov 18, 2009‎

    In broad brush strokes, fish oil, curcumin, antioxidant-rich fruits and vegetables -- they're anti-inflammatory. Saturated fats, trans fats, ...

    American Cancer Society admits mammograms and cancer screenings are over-hyped

    Natural News.com (registration) - ‎Nov 17, 2009‎

    Vitamin D, curcumin, chaparral, garlic, and aloe vera are a few of the many beneficial nutrients that will serve the body well in preventing cancer. ...

    Attracting flu virus with onion won't work

    Jackson Clarion Ledger - ‎Nov 16, 2009‎

    Turmeric, the yellow spice in curry powder, contains curcumin. This compound is being studied as a possible treatment for autoimmune diseases, ...

    Free memory tests mark Alzheimer's Awareness month

    Private MD - Brendan Missett - ‎Nov 16, 2009‎

    Researchers are also testing whether samples of the curry spice curcumin, when encapsulated in liposomes, are more effectively transferred into the ...

    Scientists Look to Incorporate Curry Ingredient into Fighting Diseases

    BETTER Health Research - Donna Parker - ‎Nov 16, 2009‎

    A study in the Journal of Agricultural and Food Chemistry is looking into nano-sized capsule made with curcumin, an ingredient that makes curry yellow, ...

    JFP Person of the Day: John Dooley

    Jackson Free Press - Ward Schaefer - ‎Nov 13, 2009‎

    ... "high-tech and ancient," for its use of natural ingredients, especially Ayurvedic herbs like noni and curcumin, to reach specific biological needs. ...

    Reverse Pre-Diabetes

    Stop Aging Now - Gale Maleskey - ‎Nov 12, 2009‎

    Curcumin: This component of the spice, turmeric, has been known to improve insulin resistance and regulate spikes in blood glucose levels. ...

    Hot Topics

    Student Direct - Erica Burnell - ‎Nov 8, 2009‎

    ... treatment in the curry spice, turmeric. Oesophageal cancer cells that were treated with curcumin, the active compound in turmeric, died within 24 hours.

    Diet a good step toward balanced health

    Flesh and Stone - ‎Nov 2, 2009

    Curcumin spice, a derivative of turmeric, is an antioxidant known in Thailand for having anti-inflammatory and anti-cancer properties. ...

    Wonder Spice

    Tonic - Courtney Rubin - ‎Oct 31, 2009‎

    They found that curcumin started to kill cancer cells in 24 hours – and that the cells began to digest themselves, according to research published in the ...

    Curcumin Kills Cancer Cells Quickly

    EndoNurse - ‎Oct 30, 2009‎

    CORK, Ireland—Researchers from the University College Cork and Mercy University Hospital, Cork, reported curcumin started killing cancer cells within 24 ...

    Curry can kill cancer cells, say Irish researchers

    Irish Central - Kenneth Haynes - ‎Oct 30, 2009‎

    Lab tests at the Cork Cancer Research Center showed that the chemical curcumin, found in turmeric, started destroying the throat cancer cells within a day ...

    Curry spice 'kills cancer cells'

    The National Online - ‎Oct 29, 2009‎

    The chemical – curcumin – has long been thought to have healing powers and is already being tested as a treatment for arthritis and even dementia. ...

    Curry Compound Kills Esophageal Cancer Cells

    Food Consumer - ‎Oct 29, 2009‎

    For the study, researchers at the Cork Cancer Research Center in Ireland treated cultured esophageal cancer cells with curcumin - the yellow pigment found ...

    Scientists find the curry spice kills cancer cells

    Examiner.com - ‎Oct 29, 2009‎

    In the current addition of the British Journal of Cancer, a team of scientists from the Cork Cancer Research Centre reported that the chemical curcumin, ...

    Curry ingredient found to have cancer treating potentials

    The Daily Inquirer - ‎Oct 29, 2009‎

    Scientists at the Cork Cancer Research Center in Ireland have treated esophageal cancer cells with curcumin. Circumin is a chemical found in the spice ...

    Daily Briefing: Thurs.

    Mother Nature Network - ‎Oct 29, 2009‎

    Curcumin — an extract from the bright yellow curry spice turmeric — has long been ascribed healing powers, and is already undergoing tests for treating ...

    Daily Digest 29 October 2009

    Pulse - Niall Hunt - ‎Oct 29, 2009‎

    The red top reports on research that the chemical curcumin, which is found in turmeric – a common curry spice – kills cancerous cells after less than 24 ...

    Curry could be spice of life for cancer patients

    Metro - Jo Steele - ‎Oct 29, 2009‎

    Previous scientific studies have suggested curcumin - which gives curries a distinctive yellow colour - can suppress tumours and that people who eat lots of ...

    Spice rack has a secret cancer weapon

    The Mercury (subscription) - ‎Oct 28, 2009‎

    Researchers at the Cork Cancer Research Centre in Ireland treated oesophageal cancer cells with curcumin - a chemical found in turmeric, which gives curries ...

    Curry spice tumeric may help fight cancer, study shows

    Examiner.com - ‎Oct 28, 2009‎

    Could be so: A chemical called curcumin, which is found in the bright-yellow curry spice tumeric, has been shown to kill cancer cells. ...

    Researchers: Spice in curry powder counteracts cancer

    WFIE-TV - Sarah Harlan - ‎Oct 28, 2009‎

    New research on Turmeric and a chemical component of it called Curcumin showed that Curcumin destroyed esophageal cancer cells within 24 hours. ...

    Curry compound killed cancer cells in lab

    CBC.ca - ‎Oct 28, 2009‎

    When scientists treated esophageal cancer cells with curcumin, found in the spice turmeric, it started to kill the cells within 24 hours, the team reported ...

    Study: Ingredient In Curry May Have Cancer-Fighting Abi...

    Ozarks First - ‎Oct 28, 2009‎

    They found that esophageal cancer cells treated with the chemical curcumin started to die off within 24 hours. The chemical also made the cancer cells start ...

    Spice up your health: eat curry

    Excalibur Online - Nicole Constant - ‎Oct 28, 2009‎

    Not surprisingly, turmeric and its most active component, curcumin, have been receiving wide-ranging scientific study, probably more so than any other spice ...

    Eat Turmeric to Fight Cancer

    Epicurious - Megan O. Steintrager - ‎Oct 28, 2009‎

    The chemical - curcumin - has long been thought to have healing powers and is already being tested as a treatment for arthritis and even dementia. ...

    Curry Powder Ingredient Fatal for Cancer Cells- Researchers

    TopNews United States - Amit Pathania - ‎Oct 28, 2009‎

    In an exciting new find, researchers reported on Wednesday that curcumin has been found effective in killing esophageal cancer cells. ...

    Curry spice kills cancer cells

    NHS Choices - ‎Oct 28, 2009‎

    This was a laboratory study investigating how oesophageal cancer cells respond when coming into contact with curcumin, a chemical found in the Indian spice ...

    Compound In Curry Kills Cancer Cells

    RedOrbit - ‎Oct 28, 2009‎

    Curcumin, a chemical found in the spice turmeric, gives curries a distinctive yellow color, but researchers at the Cork Cancer Research Center in Ireland ...

    Turmeric 'can kill cancer cells'

    Sideways News - ‎Oct 28, 2009‎

    Scientists at University College Cork (UCC) in Ireland found that curcumin, a compound found in turmeric, began killing oesophageal cancer cells within 24 ... 

    Turmeric health benefits: Study touts curcumin destroys cancer cells

    Examiner.com - ‎Oct 28, 2009‎

    A study published today (October 28, 2009) in the British Journal of Cancer reveals that curcumin, a compound in turmeric, kills esophageal cancer cells in ...

    Curry, new anti-cancer

    PRESS TV - ‎Oct 28, 2009‎

    While many studies are assessing the effects of curcumin - a compound commonly found in curry - in treating arthritis and dementia; the study published in ...

    Curry 'kills cancer cells' and other health benefits of the nation's favourite ...

    Mirror.co.uk - Ann Gripper - ‎Oct 28, 2009‎

    Scientists have identified these additional health benefits of the chemical curcumin, which is already being tried as arthritis and dementia treatment, ...

    Turmeric chemical kills cancer cells

    TheMedGuru - ‎Oct 28, 2009‎

    A team of scientists based at the Cork Cancer Research Centre conducted a lab experiment to determine the therapeutic value of chemical curcumin found in ...

    Curry kills some cancer cells

    680 News - ‎Oct 28, 2009‎

    Research done at the Cork Cancer Research Centre in Ireland shows curcumin, which is what gives curry the yellow color can kill some cancer cells in a lab ...

    Turmeric can help fight cancer

    India Business Blog (blog) - ‎Oct 28, 2009‎

    by ANI on October 28, 2009 Curcumin may protect smokers from nicotine-induced head, neck cancers Washington, October 5 (ANI): Curcumin, a compound that is ... 

    Anti-Inflammatory Supplements That Work

    Stop Aging Now - Gale Maleskey - ‎Oct 22, 2009‎

    Curcumin, a component of the yellow spice turmeric, found in curry, may have special anti-inflammatory properties in the eyes, where a layer of yellow ...

    People's Pharmacy: Curry may soothe psoriasis

    Buffalo News - Teresa Graedon - ‎Oct 22, 2009‎

    This could lead to a dangerous or even lethal bleeding episode, so no one on warfarin should take turmeric or its active ingredient curcumin. ...

    HEALTHY EATING: Spices boost health benefits, too

    Atlanta Journal Constitution - Carolyn O'Neil - ‎Oct 21, 2009‎

    Curcumin, the bright yellow pigment in tumeric, helps fight heart disease and may boost brain health, possibly protecting against Alzheimer's disease. ...

    Nutritional Support for Bladder Cancer Recovery

    EmpowHer (blog) - ‎Oct 19, 2009‎

    Curcumin from turmeric inhibited the growth of bladder cancer cells in mice and in cell cultures in studies at Texas A&M University. ...

    Tumeric extract shows promise as anti-inflammatory

    Horsetalk - ‎Oct 18, 2009‎

    The British researchers explored curcumin (diferuloylmethane), which comes from the spice turmeric. Tumeric is produced from the plant Curcuma longa. ...

    Blood clot a serious concern

    Inquirer.net - Charles E. Buban - ‎Oct 16, 2009‎

    One of these recently targeted plants include Curcuma longa (luyang dilaw) whose medicinal extract called curcumin has been found to prevent the formulation ...

    Nutritional education collaboration: American College of Nutrition 50th ...

    Examiner.com - ‎Oct 16, 2009‎

    This extremely detailed and scientific presentation also gave credence to the centuries old use of the common Indian spice, Turmeric, rich in curcumin which ...

    Cutting Edge Cancer Research: Top 10 Cancer Fighting Supplements

    Stop Aging Now - Gale Maleskey - ‎Oct 14, 2009‎

    Curcumin: This component of turmeric has emerged as a leading cancer fighter. Curcumin can disrupt cancer cells in several stages of development. ...

    Health Tip of the day: Spice up your life!

    tayyar.org - ‎Oct 13, 2009‎

    The yellow curry pigment curcumin may fight Alzheimer's by thwarting development of the disease's signature amyloid brain plaques, says a study. ...

    Osteoarthritis: Turmeric Spice Might Provide Natural Remedy

    TheHorse.com - Stacey Oke - ‎Oct 13, 2009‎

    Curcumin, an extract of the spice turmeric, is a natural product with potent anti-inflammatory properties that also exerts beneficial effects on cartilage ...

    Alzheimer's

    About - News & Issues (blog) - ‎Oct 12, 2009‎

    In previous studies, researchers have shown that natural compounds such as curcumin (an anti-inflammatory agent found in the curry spice turmeric), ...

    Curcumin Helps Diabetics Manage Inflammation

    Stop Aging Now - Carey Rossi - ‎Oct 7, 2009‎

    One thing you can do is to take a curcumin supplement. Canadian researchers found that rats treated for one month with curcumin did not experience the ...

    Death by Chocolate and Resuscitation by Golden-Yellow Powder

    Eat. Drink. Better. (blog) - Jigyasa Jyotika - ‎Oct 7, 2009‎

    Curios researchers that flocked to test the powder in the last few decades, identified curcumin as the chief active ingredient in turmeric. ...

    Polyphenol found in turmeric reduces weight gain in animal studies

    GroundReport - Anne Hart - ‎Oct 6, 2009‎

    "Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice. 919-925." Turmeric and an ingredient in it, curcumin has ...

    Alzheimer's help

    About - News & Issues (blog) - ‎Oct 6, 2009‎

    Past studies show that a combination of curcumin (a compound found in the curry spice turmeric) and vitamin D may also help clear the brain of amyloid beta. ...

    Can 'haldi' save smokers?

    Herald Publications - ‎Oct 5, 2009‎

    Curcumin, the active ingredient in turmeric or 'haldi', may inhibit the adverse effects of nicotine in patients who have head or neck cancer, but continue ...

    Attacking Arthritis Three Ways

    Christian Post - Reginald B. Cherry - ‎Oct 5, 2009‎

    Curcumin/Turmeric root - One of the best anti-inflammatories, it has been used for centuries. A Cornell University study found that it did decrease joint ...

    Gene Discovery May Advance Head and Neck Cancer Therapy

    U.S. News & World Report - ‎Oct 5, 2009‎

    MONDAY, Oct. 5 (HealthDay News) -- In a finding that could have a major impact on the diagnosis and treatment of one of the most deadly types of cancer, ...

    Curcumin may help block nicotine-induced cancer cells

    TheMedGuru - ‎Oct 5, 2009‎

    by Kangna Agarwal - October 5, 2009 New York, October 5 -- Curcumin, a yellow pigment found in turmeric, the Indian spice, may block nicotine from ...

    Curry Could Prevent Recurrence Of Head And Neck Cancers

    Gant Daily - David Goodhue - ‎Oct 5, 2009‎

    The cells were pre-treated with curcumin, the compound that gives curry its yellow/orange color. Then the scientists introduced nicotine to the cell lines. ...

    Turmeric may protect smokers from nicotine effects

    Times of India - ‎Oct 5, 2009‎

    Curcumin, a compound that is found in the India curry spice turmeric, seems to be effective in stopping nicotine's adverse effects in smokers with head and ...

    Curry Powder Ingredient May Block Nicotine Activated Cancer Cells In Head And ...

    Medical News Today - ‎Oct 5, 2009‎

    Researchers found that curcumin, a compound found in turmeric, the Indian spice that gives curry its orange-yellow colour, may block nicotine from ...

    Curry Could Prevent Recurrence Of Head And Neck Cancers

    AHN - David Goodhue - ‎Oct 5, 2009‎

    The cells were pre-treated with curcumin, the compound that gives curry its yellow/orange color. Then the scientists introduced nicotine to the cell lines. ...

    Curcumin blocks nicotine effect on head and neck cancer

    eMaxHealth - Kathleen Blanchard - ‎Oct 4, 2009‎

    Patients with head and neck cancer who continue to smoke could benefit from curcumin, the ingredient found in the spice turmeric. ...

    Genes research offers cancer hope

    The Press Association - ‎Oct 4, 2009‎

    People suffering from a deadly family of cancers have been given new hope after American scientists identified 231 previously unknown genes associated with ...

    Curcumin May Inhibit Nicotine-induced Activation Of Head And Neck Cancers

    Science Daily (press release) - ‎Oct 4, 2009‎

    ScienceDaily (Oct. 4, 2009) — Curcumin, the compound that gives curry powder its yellow/orange color, may inhibit the adverse effects of nicotine in ...

    Curry and turmeric help smokers with head and neck cancer

    Food Consumer - David Liu - ‎Oct 4, 2009‎

    Sunday Oct 4, 2009 (foodconsumer.org) -- Curcumin, the yellow pigment found in curry powder and turmeric may ...

    Curcumin found in turmeric is being researched for Alzheimer's

    TopNews - Sukhpreet Manchanda - ‎Oct 4, 2009‎

    PResearchers at the University of Southampton believe that ...

    Nutri-Pepper: Healthy Alternative to Pepper?

    HealthNews - Lara Endreszl - ‎Oct 3, 2009‎

    A study from the September issue of Psychopharmacology used piperine as well as the Ayurvedic cure curcumin (the Indian spice found in tumeric commonly used ...

    Asian Spice Could Reduce Breast Cancer Risk

    HULIQ - Mindy Hartman - ‎Oct 2, 2009‎

    University of Missouri researchers have found that curcumin, a popular Indian spice derived from the turmeric root, could reduce the cancer risk for women ...

    Indian Yellow Milk in Western Medicine

    New America Media - ‎Oct 2, 2009‎

    ... I did a little digging in the medical literature on turmeric's benefits and discovered that it contained curcumin, a potent anti-inflammatory compound. ...

    How to Stay Sharp as a Tack

    Natural News.com (registration) - Julian Whitaker - ‎Oct 2, 2009‎

    Curcumin, an extract from turmeric, curbs inflammation, and vinpocetine, a periwinkle extract, improves cerebral blood flow. Phosphatidylcholine (PC) and ...

    New Insights on Addiction, Mood, Memory, and Cognitive Ability

    NewsReleaseWire.com (press release) - ‎Oct 1, 2009‎

    Aerobic exercise and various nutrients can improve BDNF levels (pantethine, acetyl-l-carnitine, blueberries, fish oil, curcumin, and likely many others). ...

    Curcumin and Vitamin D3 may Dissolve Plaques of Alzheimer's Disease

    Natural News.com (registration) - Cindie Leonard - ‎Sep 29, 2009‎

    The theory is that the combination of vitamin D3 and curcumin stimulate the immune system in a fashion that helps clear amyloid beta, the "gunk" that forms ...

    H1N1 Swine Flu Vaccine Insert Admits It Causes Guillain-Barre Syndrome 

    Prison Planet.com - ‎Sep 29, 2009‎

    Flavonoids are third on the list, namely curcumin, quercetin, ferulic acid and ellagic acid, particularly in a mixture. The curcumin and quercetin in ...

    Prostate Cancer - Integrative Approaches

    HealthNewsDigest.com - Isaac Eliaz - ‎Sep 28, 2009‎

    Preclinical data have shown that curcumin, the major active constituent of the dietary spice turmeric, can both inhibit the formation of tumors in animal ...

    Urgent: What to Do If You Cannot Avoid Flu Shots or are Exposed to Virus Shedding

    Natural News.com (registration) - Paul Fassa - ‎Sep 26, 2009‎

    An hour or so before the shot or nasal mist spray, take a high dose of curcumin and quercetin! Blaylock says these two flavonoids mixed, even with other ...

    When lack of sleep raises the amyloid levels in your brain, does it lead to ...

    Examiner.com - ‎Sep 25, 2009‎

    So can you help lower the risk of Alzheimer's by getting more sleep and taking specific spice extracts such as curcumin (from turmeric) that reversed ...

    City MDs researching Chinese medicine

    Hamilton Spectator - ‎Sep 25, 2009‎

    A Chinese doctor will spend the next two years at St. Joseph's Healthcare doing research to show the effectiveness of using curcumin, which is an extract of ...

    Tumeric: what is it for?

    Telegraph.co.uk - Nick Sandler, Johnny Acton - ‎Sep 24, 2009‎

    Its active ingredient, curcumin, is prized in its native south Asia for its anti-inflammatory and antiseptic properties. American researchers are even ...

    Ask The Pharmacist: Six ways to protect yourself from pancreatic cancer

    Marco Eagle - Suzy Cohen - ‎Sep 24, 2009‎

    The herb curcumin may benefit people with pancreatitis or pancreatic cancer. Suzy Cohen is a registered pharmacist. The information presented here is not ...

    Eating to beat heart attack

    The Guardian - Nigeria - ‎Sep 23, 2009‎

    In vitro studies with capsaicin, dihydrocapsaicin (and curcumin) also exhibited a concentration effect for the resistance to copper-induced serum lipid ...

    Clinical trials of curcumin

    ADVANCE for Speech-Language Pathologists and Audiologists - ‎Sep 24, 2009

    They then blocked this effect by feeding the flies large doses of the spice curcumin [Sleep, 32 (8): 984-992] "Clinical trials of curcumin to reduce risk of ...

    Rosiglitazone Effects to Ameliorate Alzheimer's Disease Pathogenic ...

    Journal of Neuropsychiatry - ‎Sep 23, 2009‎

    Novel treatments with anti-inflammatory drugs, insulin, thiazolidinediones, omega 3 fatty acids, curcumin, statins, and others have brought new hope for ...

    The simple diet that can fight arthritis and Alzheimer's disease

    Daily Mail - Peta Bee - ‎Sep 21, 2009‎

    Meanwhile, neurologists at the University of California are investigating whether a combination of omega-3 fatty acids and curcumin, an antioxidant found in ...

    Thinking about Doing an Herbal Detox? The 7 Crucial Ingredients to ...

    Zikkir World (blog) - Rita Isaac - ‎Sep 21, 2009‎

    Turmeric has curcumin and will help to stimulate bile flow in the liver and can help protect the liver from the dangers of toxins. ...

    Pancreatic Cancer Among Top 5 In US--6 Ways To Protect Yourself

    Basil & Spice - Suzy Cohen - ‎Sep 21, 2009‎

    The herb curcumin may benefit people with pancreatitis or pancreatic cancer. These statements have not been evaluated by the Food and Drug Administration. ...

    Using food to battle inflammation

    Chicago Tribune - Shara Yurkiewicz - ‎Sep 20, 2009‎

    ... Disease Research Center, is looking at the potential for Alzheimer's prevention by controlling inflammation with omega-3 fatty acids and curcumin. ...

    'Luyang dilaw' kills tumor cells—scientists

    Inquirer.net - Tessa Salazar - ‎Sep 18, 2009‎

    Curcumin (or “curry” in culinary circles) is considered a tonic for the body. In a recent study published at the American Association of Pharmaceutical ...

    Reboot Your Brain? Science Says It's Possible -A Galaxy Classic

    Ethiopian Review - Raquel Leoncio - ‎Sep 18, 2009‎

    Turmeric, typically found in curry, contains curcumin, a chemical with potent antioxidant and anti-inflammatory properties. In India, it is even used as a ..

    Antioxidant ingredient in melon could relieve stress

    Gaea Times (blog) - ‎Sep 15, 2009‎

    Lately, turmeric's astonishing array of antioxidant, anti-cancer, antibiotic, antiviral and other properties have spurred a flurry of research into curcumin ...

    Turmeric Herb Supplements and Benefits for Body

    Ethiopian Review - ‎Sep 11, 2009‎

    Scientific evaluation has shown that the rhizomes, an underground stem system, of the plant contain curcuminoids, primarily curcumin. ...

    Ask The Pharmacist: Diseases linked to high insulin

    Marco Eagle - Suzy Cohen - ‎Sep 10, 2009‎

    These supplements include vitamin D, resveratrol, quercetin, lipoic acid, curcumin and L-arginine. The extended version of this column is posted at my Web ...

    The Science Behind Nutritional Cosmetics

    Inside Cosmeceuticals.com - Robert M. Blair, Aaron Tabor - ‎Sep 10, 2009‎

    While these ingredients are too numerous to mention them all, some of the better-known antioxidants include green tea, pomegranate, curcumin, resveratrol, ...

    Edible Ibuprofen

    Bicycling - Michaeleen Doucleff - ‎Sep 8, 2009‎

    TURMERIC Loaded with a potent antiinflammatory compound called curcumin, this yellow spice may help to increase endurance and speed recovery. ...

    Cats 101: Can a spice in curry help your feline furry fight cancer?

    Examiner.com - Sanjay Acharya - ‎Sep 8, 2009‎

    Curcumin, a compound found in turmeric (a spice best known as an ingredient in curry), is the focus of a feline cancer study being conducted by the Colorado ...

    Genetic mutations raise Alzheimer's risk, healthy lifestyle cuts ...

    Food Consumer - David Liu - ‎Sep 6, 2009‎

    Vitamin D, curcumin, Mediterranean diet each may help reduce the risk of Alzheimer's disease. UCLA in July 2009 issued a press release to announce that its ..

    Eat to stay young

    DesMoinesRegister.com - Jennifer Miller - ‎Sep 5, 2009‎

    Although it provides high levels of iron and manganese, its most valued component is curcumin, which has been studied for its anti-inflammatory properties. ...

    15th Fi-Asia to co-host Food Ingredients Asia Conference

    fnbnews.com - ‎Sep 4, 2009‎

    Chelating property of Curcumin and Trends in food ingredients in Taiwan. " UMAMI Technology and Functional beverage ingredients: the industry review. ...

    Exotic Spice Protects Women on Hormone Therapy from Breast Cancer

    Oncology Nursing News - Tasheema Prince - ‎Sep 4, 2009‎

    Curcumin, a popular Indian spice, blocks breast cancer cell growth in women on hormone replacement therapy, say researchers at the University of Missouri. ...

    Nutrients Show Promise in the Battle Against Brain Decay

    Stop Aging Now - Carey Rossi - Sep 3, 2009‎‎

    Both studies found that curcumin, a derivitative of the curry spice, turmeric, to have neuroprotective effects. Researchers from UCLA, UC Riverside and the ..

    HerbalScience Research Demonstrates that Optimized Turmeric ...

    Reuters - ‎Sep 3, 2009‎‎

    This result indicates that an enriched turmeric extract could be just as or more effective than curcumin, the most commonly studied turmeric material for ...

    Turmeric - a natural alternative for inflammation relief

    Examiner.com - ‎Sep 3, 2009‎‎

    It has an ingredient called curcumin that is the important factor in reducing inflammation. Indian's have known about turmeric for centuries and use it in ...

    Developing drug targets for malaria

    pharmabiz.com - Nandita Vijay - ‎Sep 3, 2009‎

    One of them is the curcumin combination to control the parasite. "Our research has provided new knowledge on parasite biology which could pave the way for ...

    Curry Spice May Cut Cancer Risk

    About - News & Issues - ‎Sep 2, 2009‎

    Curcumin—a compound found in the curry spice turmeric—may help reduce breast cancer risk for women undergoing hormone replacement therapy during menopause, ...

    Novel h1n1 RNA virus

    Basil & Spice: Author & Book Views On A Healthy Life! - James Geiger - ‎Sep 1, 2009‎

    Curcumin (diferuloylmethane): a yellow pigment in the spice turmeric (also called curry powder) possess potent antiviral activities against severe acute ...

     

    'Hey guys, try being nice to your prostate'

    North Island Midweek - Ingrid Pincott - ‎Aug 31, 2009‎

    Levels of 25(OH) at 120nmol/L will prevent cancers in general and most adults need upwards of 2000 iu's per day. q Curcumin is an excellent ...

    Spice derivative could prove useful in feline cancer therapy

    DVM 360 - ‎Aug 29, 2009‎

    Curcumin, a compound in turmeric, appears to stop the growth of cancer in laboratory cell tests. Turmeric is an herb related to ginger that is often used in ...

    Curcumin serves as aid to fight cancer -- also helps Alzheimer's ...

    Examiner.com - ‎Aug 29, 2009‎

    Curcumin is being discovered to help many problems associated with Alzheimer's, arthritis, depression, cancer, etc. It is an Indian spice derived from ...

    Nutrients & HealthIs This Why Some Cultures Have Less Alzheimer's?

    Total Health Breakthroughs - Joseph F. McCaffrey - ‎Aug 28, 2009‎

    They incubated these white blood cells in the presence of amyloid and then added vitamin D3 and curcumin to the mix, both individually and together. ...

    NIH Announces Funding Opportunities for ncRNA Research in Cancer ...

    GenomeWeb Daily News - ‎Aug 25, 2009‎

    New findings suggest that dietary components such as folate, retinoids, and curcumin can have anti-cancer effects by modulating miRNA expression, ...

    Prostate Cancer Treatment Choices

    Food Consumer - Mark Sircus - ‎Aug 21, 2009‎

    [9] In studies involving mice, curcumin has demonstrated anti-carcinogenic activity in a variety of cancers.[10] A compound in aged garlic significantly ...

    Eating Curry Fights Dementia

    Natural News.com - David Gutierrez - ‎Aug 20, 2009‎

    Researchers conducted experiments on the effects of curcumin, a biologically active ingredient of the essential curry spice turmeric. ...

    Farmers' markets - the ultimate LA secret?

    Examiner.com - ‎Aug 20, 2009‎

    Laboratory tests of resveratrol (derived from grapes) and curcumin (derived from turmeric) show promise in improving blood vessel function, ...

    Ask The Pharmacist: Put the fire out in arthritis without fear of ...

    Marco Eagle - Suzy Cohen - ‎Aug 18, 2009‎

    Curcumin: Derived from turmeric spice — studies show it's a very powerful anti-cancer and anti-inflammatory herb. Resveratrol: You know it as a red wine ...

    Black Tea For Diabetes Management

    About - News & Issues - ‎Aug 18, 2009‎

    Past research suggests that natural substances such as cinnamon, curcumin (a compound found in the curry spice turmeric), and ginseng may also help fight ...

    Turmeric Extract for Your Joints, Not Just Your Spice Rack

    Christian Post - Reginald B. Cherry - ‎Aug 17, 2009‎

    Curcumin is a yellow pigment derived from turmeric, which is commonly used as a spice and food-coloring agent. Turmeric has a long history of use in eastern ...

    Vitamin D3 and Curcumin Offer Hope to Alzheimer's Patients

    Natural News.com - Barbi Trejo - ‎Aug 17, 2009‎

    Promising results were obtained, using D3 alone or together with curcumin, an active ingredient in turmeric and curry. There is new hope that these two ...

    Exotic Spice Protects Women on Hormone Therapy from Breast Cancer

    American Journal of Hemotology and Oncology - Tasheema Prince - ‎Aug 17, 2009‎

    Curcumin, a popular Indian spice, blocks breast cancer cell growth in women on hormone replacement therapy, say researchers at the University of Missouri. ...

    Battling inflammation, disease through food

    Los Angeles Times - ‎Aug 14, 2009‎

    And curcumin (an antioxidant chemical found in turmeric) improves ulcerative colitis, rheumatoid arthritis and pancreatitis in mice and has anti-cancer ...

    Turmeric Fights Body Fat

    Natural News.com - David Gutierrez - ‎Aug 13, 2009‎

    "Based on our data, curcumin appears to suppress angiogenic activity in the fat tissue of mice fed high fat diets." Curcumin is an antioxidant chemical in ..

    Pharmacist - How can I avoid prostate cancer?

    StarNewsOnline.com - ‎Aug 13, 2009‎

    Ask your doctor if these are right for you: Quercetin, curcumin, lycopene, beta sitosterol, melatonin and natural anti-fungals.

    Studies on Alzheimer's suggest yes on vitamin D3 and curcumin & no ...

    Examiner.com - ‎Aug 13, 2009‎

    What about turmeric or curcumin for preventing Alzheimer's if you're not able to fight the environmental pollution where you have to live? ...

    Curry Ingredient, Vitamin D May Fight Alzheimer's Disease

    24 Medica - Glenn Rosenberg - ‎Aug 12, 2009‎

    A combination of curcumin (a compound found in the curry spice turmeric) and vitamin D could help protect against Alzheimer's disease, according to a recent ...

    What drug-free help can we give Alzheimer's patients?

    Examiner.com - ‎Aug 11, 2009‎

    Curcumin and Ginko may slightly reduce the risk of becoming demented but do nothing to help cognition once decline has begun. Omega 3 fatty acids seem to ...

    THE MICHAEL J.FOX FOUNDATION FUNDS NINE NEW APPROACHES

    Parkinson's Disease News - ‎Aug 11, 2009‎

    Exploring curcumin (which is found in a curry spice) as a possible treatment of Parkinson's Disease [2]. Curcumin is already widely used, due to its ready ...

    Supplements may help protect against Alzheimer's

    Personal Liberty Digest - ‎Aug 10, 2009‎

    A new study has found a combination of supplements containing vitamin D3 and curcumin, a compound found in turmeric, may help shield the brain from the ..

    Curcumin may be viable supplement to treat inflammatory bowel ...

    The Virtual Medical Centre - ‎August 6, 2009‎

    Now, researchers at the Steele Children's Research Center at the University of Arizona have found that curcumin (the biologically active ingredient in ...

    Dementia Induced And Blocked In Parkinson's Fly Model

    Science Daily (press release) - ‎August 3, 2009‎

    They then blocked this effect by feeding the flies large doses of the spice curcumin. "Clinical trials of curcumin to reduce risk of Parkinson's disease are ...

    Turmeric, early Alzheimer's disease prevention and reversal ...

    Examiner.com - ‎Jul 31, 2009‎

    Is it true that research is beginning to show that an ingredient, a phytochemical, in turmeric called curcumin, actually reverses, slows, or even helps to ...

    'Nature is a treasure trove of compounds'

    TopCancerNews.com - ‎Jul 29, 2009‎

    This would seem unlikely, with similar effects reported for other components of wine and for other natural products such as curcumin. ...

    Curcumin may benefit inflammatory bowel disease patients

    eMaxHealth - ‎Jul 29, 2009‎

    Curcumin, the active ingredient in turmeric, may be an effective treatment for inflammatory bowel disease, also known as IBD. Researchers at the Steele ...

    Kitchen Rescue Thai herbal-coated rice perfect for kebabs

    Inquirer.net - Reggie Aspiras - ‎Jul 29, 2009‎

    Turmeric has active substances—polyphenol and curcumin, a strong antioxidant. In Ayurveda, turmeric blocks inflammation, anti-gastric flux and improves the ...

    Neuroprotective properties of green tea 101: implications to ...

    Examiner.com - ‎Jul 29, 2009‎

    As reviewed in previous articles, ingesting curcumin, the main component of curry, or ingesting high amounts of phenethyl isothiocyanate , a compound found ...

    Eight Fat Busting Supplements Backed by Science

    Natural News.com - Stephanie Ann Whited - ‎Jul 28, 2009‎

    Curcumin (in Turmeric) - When fed a high fat diet, mice fed curcumin gained less weight. BONUS: These lucky mice also showed lower cholesterol levels and ...

    Q&A: 'Turmeric is receiving attention for medical applications'

    Times of India - ‎Jul 23, 2009‎

    We used solid state NMR spectroscopy on curcumin to discover how its molecules act like a biochemical disciplinarian. In our very recent research, ...

    Turmeric, garlic, others offer protection against aflatoxin ...

    The Guardian - Nigeria - ‎Jul 22, 2009‎

    Also, University of Missouri, United States, researchers have found that curcumin, a popular Indian spice derived from the turmeric root, could reduce the ...

    Turmeric: An antioxidant to add to the power-food list

    Columbia Daily Tribune - Marcia Vanderlip - ‎Jul 22, 2009‎

    An increasing body of research shows curcumin, the main active ingredient in turmeric root, is a powerful antioxidant and anti-inflammatory that could fight ...

    Turmeric prices shoot up on short supply, export demand

    Hindu Business Line - Gk Nair - ‎Jul 22, 2009‎

    Consequently, the demand for the 'Alleppey Finger Turmeric (AFT)', which is famous for its high curcumin content, has dropped considerably in recent years ...

    AHA: Indian Spice, Orange Juice May Be Cardioprotective Curcumin ...

    Modern Medicine - ‎Jul 21, 2009‎

    After 16 weeks, they found that mice fed curcumin had a 26 percent reduction in lipid deposits, and an examination of gene expression showed that the ...

    Curcumin may Prevent Breast Cancer in Women Who Took Hormones

    Natural News.com - Sherry Baker - ‎Jul 21, 2009‎

    University of Missouri researchers have found that curcumin, a popular Indian spice derived from the turmeric root, could reduce the risk of breast cancer ...

    East Indian spice may improve health

    Bartlesville Live - ‎Jul 21, 2009‎

    Researchers say curcumin, which gives curry that distinctive yellow color, lowered levels of fat deposits in Mice. A news release on the study states, ...

    Michael J. Fox Foundation Awards $3.8 Million To Drive Nine ...

    Business Exchange - ‎Jul 21, 2009‎

    ... disease-modifying drug candidate for treatment of Parkinson's disease Gerard Griffioen, PhD, NV reMYND, Leuven, Belgium Exploring curcumin and. ...

    Indian food spice cuts risk of breast cancer in HRT therapy

    The West Australian - ‎Jul 21, 2009‎

    Researchers found curcumin, a component of the spice turmeric, inhibited progestin-induced VEGF secretion from breast cancer cells. Curcumin decreased the ...

    Curcumin and vitamin D may protect against Alzheimer's disease

    Examiner.com - ‎Jul 21, 2009‎

    Curcumin and vitamin D—both individually and together—appear to have properties that help protect against Alzheimer's disease. Does this mean you should ...

    Studies Show Genetic Activity of Antioxidants

    U.S. News & World Report - Ed Edelson - ‎Jul 21, 2009‎

    Two French research teams are reporting studies describing the range of genes that are affected by curcumin, the active ingredient in turmeric, ...

    30 Healthy Cholesterol Tips

    Reader's Digest - ‎Jul 21, 2009‎

    Small studies have found that curcumin, a component of turmeric, cuts cholesterol. Heat a little oil in a sauté pan, and toss in a tablespoon of turmeric, ...

    Fight fat with vinegar and peppers

    Buffalo News - Rallie McAllister - ‎Jul 21, 2009‎

    As long as you're spicing up your diet and weight-loss routine with capsaicin, you might as well add a little curcumin, the bioactive component in turmeric ...

    Curcumin May Prevent Clogged Arteries

    WebMD - Kelli Miller Stacy - ‎Jul 20, 2009‎

    Curcumin, the main ingredient in the curry spice turmeric, is a naturally occurring antioxidant known as a polyphenol. Polyphenols are found in plants that ...

    Antioxidant in Orange Juice Linked to Better Blood Vessel Health ...

    WebMD - Kelli Miller Stacy - ‎Jul 20, 2009‎

    July 20, 2009 -- An apple a day is said to keep the doctor away, but orange juice may be good at the job, too. ...

    Home remedies for pain relief

    KGO-TV - ‎Jul 20, 2009‎

    Turmeric, known as curcumin, reduces inflammation in the body, and recent medical studies indicate that men who eat turmeric consistently have lower levels ...

    Spice may benefit women who took HRT

    Personal Liberty Digest - ‎Jul 20, 2009‎

    New research shows that curcumin found in the Indian spice turmeric may help reduce some women's risk of breast cancer if they utilized hormone replacement ...

    Health News: Vitamin D and Curry May Prevent Alzheimer's

    KEYC - ‎Jul 19, 2009‎

    Researchers say properties of vitamin d and curcumin...which is found in the curry spice, turmeric, may help stimulate the immune system to clear the brain ...

    Polyphenols and health

    Malaysia Star - Tee E Siong - ‎Jul 18, 2009‎

    Its major active constituent is the polyphenol curcumin (diferuloylmethane). It exhibits several molecular targets and is similar to many other phenolic ...

    Turmeric may help lower breast cancer risk

    RedOrbit - ‎Jul 17, 2009‎

    The study, published in the journal Menopause, found curcumin -- a component of the spice turmeric -- delayed the first appearance, decreased incidence and ...

    Stimulating Immune Response May Help Clear Alzheimer's Plaques

    MedPage Today - Kristina Fiore - ‎Jul 17, 2009‎

    Explain that vitamin D and curcumin helped stimulate macrophages, part of the immune system response. Note that macrophages typically clear plaques in ...

    Madness and genius, rare Neanderthals, vitamin D vs Alzheimer's ...

    Examiner.com - ‎Jul 17, 2009‎

    ... together with a chemical found in turmeric spice called curcumin, may help stimulate the immune system to clear the brain of amyloid beta, ...

    Vitamin D, spice may fight Alzheimer's

    United Press International - ‎Jul 16, 2009‎

    "We hope that vitamin D3 and curcumin, both naturally occurring nutrients, may offer new preventive and treatment possibilities for Alzheimer's disease," ...

    Vitamin D and curcumin may fight Alzheimer's disease

    Private MD - Frank Mayweather - ‎Jul 16, 2009‎

    In a recent study from UCLA and UC Riverside, researchers found that vitamin D, combined with curcumin - a chemical found in the spice turmeric, ...

    Race For Alzheimer's Cure

    InjuryBoard.com - Jane Akre - ‎Jul 16, 2009‎

    Curcumin is found in the curry spice, turmeric. Together with properties of vitamin D (D3), they may help stimulate the immune system to clear the brain of ...

    Vitamin D and curcumin may be useful in clearing away Alzheimer ...

    HealthJockey.com - ‎Jul 16, 2009‎

    Now it seems that the curcumin chemical found in turmeric, along with a form of vitamin D (vitamin D3) may be useful in clearing away amyloid plaques found ...

    Can an herb prevent obesity?

    Personal Liberty Digest - ‎Jul 15, 2009‎

    One of the groups also received supplementation of 500 mg of curcumin, a polyphenol found in turmeric, per 1 kg of food. The researchers found that the mice ...

    New Treatments for Alzheimer's on the Horizon

    Atlanta Journal Constitution - ‎Jul 15, 2009‎

    ... when combined with a chemical found in a spice called curcumin, may help stimulate the immune system to clear the brain of amyloid beta. ...

    Turmeric Shown to be Natural Remedy Against Alzheimer's

    Natural News.com - Sheryl Walters - ‎Jul 15, 2009‎

    The active ingredient in turmeric that makes it such a great medical tool is called curcumin. Curcumin has been found to be a powerful anti-inflammatory and ...

    Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In ...

    Science Daily  - ‎Jul 15, 2009‎

    "We hope that vitamin D3 and curcumin, both naturally occurring nutrients, may offer new preventive and treatment possibilities for Alzheimer's disease," ...

    MU researchers link spice to reduced risk of breast cancer

    Columbia Missourian - James Ostler - ‎Jul 14, 2009‎

    COLUMBIA — MU researchers have found that curcumin, an Indian spice derived from the turmeric root, could potentially reduce the risk of ...

    Spicing Up Cancer Prevention

    KOMU-TV - ‎Jul 14, 2009‎

    Researchers found that a common spice in Asian food, curcumin, prevents breast cancer in many rats treated with hormone replacement medications. ...

    Is People Food Safe for Dogs?

    Examiner.com - Acai Berry - ‎Jul 14, 2009‎

    Both paprika (Capsicum annuum) and turmeric (Curcuma longa) contain irritants (capsaicin and curcumin, respectively) that can cause irritation to the skin, ...

    Cancer and Supplements: What Vitamins, Herbs, and Botanicals Can ...

    U.S. News & World Report - Katherine Hobson - ‎Jul 14, 2009‎

    Curcumin (derived from the spice turmeric), quercetin (a kind of plant pigment), and a host of other food-derived chemicals, vitamins, and herbal products ...

    Turmeric cuts down cancer risk in women

    Smash Hits - ‎Jul 14, 2009‎

    Researchers have now found that curcumin, a popular Indian spice derived from the roots of turmeric, could cut down the risk of cancer in women who take to ...

    Turmeric cuts postmenopausal breast cancer risk

    Times of India - ‎Jul 14, 2009‎

    WASHINGTON: Curcumin, a popular Indian spice derived from the turmeric root, can help reduce cancer risk among postmenopausal women exposed to hormone ...

    Fruits and Vegetables Shown to Reduce Risk of Breast Cancer and ...

    Natural News.com - Barbara Minton - ‎Jul 13, 2009‎

    ... apigenin from celery and parsley, curcumin from turmeric, epigallocatechin-3-gallate (EGCG) from green tea, resveratrol from red grapes and peanuts, ...

    Compound's Health Potential

    Wine Spectator - Jacob Gaffney - ‎July 12, 2009‎

    The scientists looked at chemical compounds analyzed in research papers and found that some, such as curcumin, which is found in the curry ingredient ...

    Book Review: The Good Life

    Diet Blog - Mike Howard - ‎Jul 6, 2009‎

    According to Dr. Michael Roizen, the best supplements are DHA, Vitamin D, Tomato sauce and mustard (curcumin). Some top herbs - according to "medicine ...

    Living Well

    Planet Jackson Hole - Teresa Griswold - ‎Jul 2, 2009‎

    Turmeric's effective compound, curcumin is both a powerful anti-inflammatory and antioxidant and is used to treat arthritis in India. ...

    Power of a curry

    Fiji Times - ‎Jul 2, 2009‎

    The key ingredient is curcumin, a component of the spice turmeric. Curcumin appears to prevent the spread of amyloid protein plaques - thought to cause ...

    Natural alternatives to acetaminophen

    Examiner.com - ‎Jul 2, 2009‎

    Curcumin: The herb turmeric contains curcumin, a substance that can block substance P from sending pain messages to the brain. A suggested dose is 400 to ...

    Woman's Weekly Wellbeing: Weight loss

    goodtoknow - ‎Jun 29, 2009‎

    A study published in the Journal Of Nutrition found that curcumin, the major ingredient in turmeric, could inhibit the development of fat cells. ...

    Getting that natural look, naturally

    Calgary Herald - ‎Jun 29, 2009‎

    ... on the ancient Indian medicine system, Ayurveda, which have combined curcumin from turmeric and antioxidants with a surprisingly short ingredient list. ...

    Herbal Detox

    Alternative Health Journal - Sylvia Anderson - ‎Jun 29, 2009‎

    Turmeric has curcumin and will help to stimulate bile flow in the liver and can help protect the liver from the dangers of toxins. ...

    Nutrition quiz

    Detroit Free Press - Sam McManis - ‎Jun 28, 2009‎

    Or you could try consuming curcumin, a compound found in the spice turmeric, a staple of some Asian diets. Test your knowledge of curcumin with this quiz. ...

    Indian Curry Breaks Up Dementia Plaques In Mice

    Inventorspot - ‎Jun 27, 2009‎

    Professor Murali Doraiswamy at Duke took mice that had these brain plaques and fed them large amounts of curcumin, a curry spice contained in the turmeric ...

    Chemotherapy is not the only way to fight cancer

    Merinews - ‎Jun 27, 2009‎

    We recommend JIVA fermented soy and herbal spice nutritional beverage, which contains the highest quality non-GMO fermented whole soy protein, curcumin C3 ...

    Study: Curcumin could stall spread of fat

    South Bend Tribune - ‎Jun 23, 2009‎

    According to a study in the May issue of the Journal of Nutrition, curcumin could stall the spread of fat tissue by: a) inhibiting new blood vessel growth; ...

    Sunday alternative medicinal products  

    Daily Kos - ‎Jun 21, 2009‎

    In this pandemic unfolding in our midst, although a mild one for now and sharing with you the virtues of Curcumin and Herbs today I will share results of ...

    Supplements for your pet

    Examiner.com - ‎Jun 20, 2009‎

    Curcumin may provide an inexpensive, well-tolerated, and effective treatment for inflammatory bowel disease (IBD) such as Crohn's and ulcerative colitis, ...

    Spicing up your diet can help your health

    Edmonton Sun - Gifford Jones - ‎Jun 20, 2009‎

    But it's actually curcumin in turmeric, the cause of the yellow colour, that interests scientists. Dr. Bharat Aggarwal, professor of cancer research at the ...

    Scientific validation of herbs – the science of alternative ...

    Examiner.com - ‎Jun 16, 2009‎

    Turmeric (Curcumin) – Turmeric is a spice common in Indian foods. It is gold or yellow and gives the food a vibrant color. Much research has been done on ...

    Sunshine does not cause cancer

    BlueRidgeNow.com - ‎Jun 16, 2009‎

    ... 2009 and 2006; Dr. Rosenfeld (Parade, June 19, 2005) “now” agrees. n Eat high levels of fruits, vegetables, antioxidants, Co-Q-10, green tea, curcumin, etc.

    Common Spices Work Better than Aspirin to Stop Blood Clots

    Natural News.com - Barbara Minton - ‎Jun 15, 2009‎

    This ability was shown by the other tested compounds in the declining order of curcumin, cinnamaldehyde, piperine, allyl sulphide, and quercetin. ...

    Food alone will not nourish

    24 Hours Vancouver - Elena Krasnov - ‎Jun 14, 2009‎

    Herbs such as green tea extract and curcumin are now frequently added to the daily multivitamin/mineral formula. They are among many phyto-chemicals that ...

    Curry may help fight dementia

    Food Consumer - ‎Jun 13, 2009‎

    The research, by Professor Murali Doraiswamy from Duke University, showed diets high in curcumin (found in turmeric) helped dissolve amyloid protein plaques ...

    Simply Fit

    Prescott Daily Courier - Pamela Liuzzo - ‎Jun 12, 2009‎

    There is a “magic” component in curry called curcumin that has been shown to decrease the risk of getting Alzheimer's and dementia. ...

    Beneficial for health

    Times of India - ‎Jun 12, 2009‎

    This would seem unlikely, with similar effects reported for other components of wine and for other natural products such as curcumin. ...

    Hot and healthy: Curry cure

    XPRESS - ‎Jun 10, 2009‎

    Curcumin, a component of turmeric, that's used in curries, appears to prevent the spread of amyloid protein plaques, which are suspected to cause dementia, ...

    Obesity's Strain Causing More Back Pain

    Online - International News Network - ‎Jun 10, 2009‎

    His team would like to try giving curcumin to women who know they have a high risk of breast cancer -- such as those who have a mother or sister with the ...

    Turmeric fights breast cancer in mice

    Online - International News Network - ‎Jun 10, 2009‎

    Tests in mice showed that curcumin, an active compound found in turmeric, helped stop the spread of breast cancer tumor cells to the lungs. ...

    Turmeric curry keeps dementia at bay

    Times of India - ‎Jun 6, 2009‎

    WASHINGTON: Turmeric curry once or twice a week could keep Alzheimer's disease and dementia at bay, thanks to a magic ingredient curcumin found in the spice ...

    Expert calls for overhaul of 'outdated' Alzheimer's care

    Private Healthcare UK - ‎Jun 6, 2009‎

    ... claimed that eating curry twice a week can help reduce the risk of developing Alzheimer's disease, thanks to the properties of the key ingredient curcumin.

    Weekly curry could prevent Alzheimer's, study reveals

    Private Healthcare UK - ‎Jun 5, 2009‎

    In particular, the team of scientists believes that curcumin, which helps to make up the spice tumeric, works to prevent the spread of amyloid protein ...

    How good ol' turmeric prevents Alzheimer's

    Mid-Day - ‎Jun 5, 2009‎

    According to Prof Doraiswamy, who grew up in Madras, the magic ingredient in curry is curcumin, a component of the spice turmeric. ...

    Researchers Uncover Why Turmeric Helps Heal

    U.S. News & World Report - ‎Jun 5, 2009‎

    It's long been believed that curcumin -- the main ingredient in turmeric -- is responsible for its healing power, but it hasn't been known how curcumin ...

    Turmeric May Help Prevent Alzheimer's

    NewsMax.com - ‎Jun 5, 2009‎

    Murali Doraiswamy, director of the mental fitness laboratory at the Duke University Medical Center's psychiatry department, told a conference that curcumin, ...

    Does a curry a day keep dementia at bay?

    meatinfo.co.uk - ‎Jun 5, 2009‎

    US researchers have found that curcumin - an ingredient in popular curry spice tumeric - blocks the spread of amyloid plaques, the toxic protein deposits ...

    Curry Consumption Could Reduce Dementia Risk

    MedIndia - ‎Jun 4, 2009‎

    It contains a substance called curcumin, which is useful in disbanding amyloid protein plaques in the brain, which are responsible for dementia. ...

    Shades of Mother Nature

    Jakarta Post - ‎Jun 4, 2009‎

    ... ranging from those whose color will fade quickly, such as curcumin, to those whose color will become stronger over time, such as alizarin and moridin. ...

    Curcumin Health Benefits: Curcumin Boosts Immunity

    Stop Aging Now - ‎Jun 4, 2009‎

    By Carey Rossi Curcumin, the natural pigment that gives the curry spice turmeric its yellow color, has developed quite an impressive reputation for it ...

    Curry, the new weapon in the war on Alzheimer's

    Mail on Sunday - ‎Jun 4, 2009‎

    According to Professor Murali Doraiswamy, the magic ingredient is curcumin, a component of the spice turmeric. Curcumin prevents the spread of harmful ...

    Study: Serving Of Curry Daily Might Keep Dementia At Bay

    Ozarks First - ‎Jun 4, 2009‎

    The key ingredient in curry is curcumin, a component of the spice turmeric. The ingredient appears to prevent the spread of amyloid protein plaques in the ...

    Ancient breaking news: Turmeric soothes

    Southside Times - ‎Jun 4, 2009‎

    You eat the ancient, yellow, healing spice, also called curcumin, every day in mustard, curry and cheese. It flavors and colors milk drinks, dairy products, ...

    Can eating of Indian curry meal stave off dementia?

    Little About - ‎Jun 4, 2009‎

    What is curcumin? Well, curcumin is an ingredient in turmeric. It has the competence to prevent changes in the brain by blocking the spread of amyloid ...

    The Spice, Turmeric, May Help To Fight Alzheimer's Disease

    HULIQ - ‎Jun 4, 2009‎

    Curcumin, a component of turmeric, a spice often used in curries, appears to prevent the spread of amyloid protein plaques in the brain. ...

    A Weekly Curry May Fight Dementia According to New Research

    The Spoof (satire) - ‎Jun 4, 2009‎

    "In the past we thought curcumin, a component of the spice turmeric was responsible. We believed that curcumin prevented the spread of amyloid protein ...

    A standard ingredient of the common curry can help prevent ...

    Hospital Healthcare Europe - ‎Jun 4, 2009‎

    Indian-born US expert Professor Murali Doraiswamy said part of the spice turmeric - called curcumin - prevents changes in the brain linked to the disease by ...

    'A study is being carried out on curcumin'

    The Publican - ‎Jun 4, 2009‎

    A study is being carried out on curcumin, which is found in turmeric. Scientists at the University of California believe it destroys plaques that build up ...

    Turmeric Extract for Weight Loss?

    Diet Blog - ‎Jun 4, 2009‎

    A Tufts University study has found that curcumin, a polyphenol found in turmeric, has shown promise as a weight loss aid...in mice. ...

    Eating curry can prevent dementia: US research

    Andhra Cafe - ‎Jun 4, 2009‎

    iStudies in America have already produced strong evidence that curcumin combats dementia and that a clinical trial ...

    'Curry stops Alzheimer's'

    Mirror.co.uk - ‎Jun 3, 2009‎

    Scientists at the University of California believe it destroys plaques that build up on nerve cells and stop them communicating. ...

    Spicy Indian curry thwarts Alzheimer's, dementia

    TheMedGuru - ‎Jun 3, 2009‎

    Curcumin, a component of spice turmeric, appears to foil the spread of these amyloid protein and thus, wards off dementia, noted Professor Murali Doraiswamy ...

    Weekly curry meals may help ward off dementia

    HealthCentral.com - ‎Jun 3, 2009‎

    The key ingredient in curries--curcumin--is a component of the spice turmeric, which has been shown to help prevent the formation of beta-amyloid plaques in ...

    Curries 'may fight Alzheimer's'

    The Press Association - ‎Jun 3, 2009‎

    A clinical trial is now under way in California to test the effects of the agent, curcumin, on a group of Alzheimer's patients. ...

    Indian curry could prevent Alzheimer's disease, dementia

    Hindu - ‎Jun 3, 2009‎

    Curcumin, a component of turmeric, appears to prevent the spread of amyloid protein plaques, which are suspected to cause dementia, Murali Doraiswamy of ...

    Natural Ways to Reduce Cancer Risk

    Best of Times - ‎Jun 2, 2009‎

    These include rosemary, broccoli, olives, ground flaxseed, probiotics, cat's claw, curcumin, omega 3 fatty acids, ginger, N-acetylcysteine, spirulina and ...

    Curcumin and chronic fatigue syndrome

    Examiner.com - ‎Jun 2, 2009‎

    Recent research is turning up promising information about curcumin, an active component of the herb turmeric. Oxidative stress is a significant factor in ...

    Ireland and Britain's favorite curry dishes

    Irish Central - ‎Jun 1, 2009‎

    Curcumin, found in the curry spice turmeric, possesses potent antioxidant and anti-inflammatory properties. It's known that long-term users of ...

    Clinical trial will focus on compound

    Shreveport Times - ‎Jun 1, 2009‎

    Other LSU Health Sciences Center researchers are studying the anti-cancer effects of curcumin, resveratol and ginger, all natural substances. ...

    Why curry could STOP you putting on weight

    Daily Mail - ‎Jun 1, 2009‎

    Turmeric contains a plant-based chemical called curcumin which is easily absorbed by the body, according to a study from Tufts University in Boston. ...

    Turmeric may be instrumental in restraining fat tissue growth

    HealthJockey.com - May 31, 2009‎

    Curcumin, the key polyphenol in turmeric, seems to also aid in restraining the growth of fat tissue in animal models. This added advantage of turmeric was ...

    How to be someone who never gets sick

    Sarasota Herald-Tribune - ‎May 28, 2009‎

    Ginger and curcumin, a component of the spice turmeric, found in curries and some yellow mustards, help ward off infection. While being out in the world ...

    Looking for New Uses for Spices -- in the Medical Lab

    Voice of America - ‎May 25, 2009‎

    Several years ago, scientists in Singapore investigated curcumin, from the curry spice turmeric. The scientists based their study on earlier evidence that ...

    Eating turmeric may help keep you stay trim

    Green Right Now - ‎May 18, 2009‎

    By Barbara Kessler You've already heard about how curcumin, or turmeric, may help reduce your chances of getting Alzheimer's, a disease that is virtually ...

    Turmeric Extract Suppresses Fat Tissue Growth In Rodent Models

    Science Daily (press release) - ‎May 18, 2009‎

    ScienceDaily (May 18, 2009) — Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue ...

    Alzheimer's Scary Link To Diabetes

    Chemical & Engineering News - ‎May 18, 2009‎

    One potential source for such a drug is curcumin, the polyphenolic yellow-orange curry spice derived from the turmeric plant. Schubert's group is working on ...

    Intel ISEF winners announced

    Science News - ‎May 15, 2009‎

    In biochemistry, Anartya Mandal of Brighton, Mass., won for research into inhibiting cancer cells with curcumin. Ronit Abramson of San Diego won in cellular ...

    HEALTHY EATING: Antioxidant glutathione is particularly high in ...

    The Patriot Ledger - ‎May 13, 2009‎

    Nutrients, such as vitamin C, Curcumin (the spice Tumeric), Vitamin B-12, and selenium assist in glutathione production. All can be obtained from a healthy ...

    Curcumin inhibits adipogenesis [fat formation] in 3T3-L1 ...

    ProHealth - ‎May 12, 2009‎

    We investigated the effect of curcumin, the major polyphenol in turmeric spice, on angiogenesis, adipogenesis, differentiation, apoptosis [programmed cell ...

    Brighton's Anartya Mandal, Boston Latin School student, receives ...

    Allston-Brighton TAB - ‎May 12, 2009‎

    ... the Genzyme Science Award as the Fair's Grand Prize recipient for his project entitled “Curcumin Induces Apoptosis in Cancer Cells by Inhibiting NF-kB”. ...

    Curried salmon, anyone?

    Morganton News Herald - ‎May 12, 2009‎

    For decades, we've known that the yellow pigment in turmeric, called curcumin, exerts potent antioxidant and anti-inflammatory effects in cells and animals. ...

    Locals return from science fair with awards

    North Attleborough Free Press - ‎May 7, 2009‎

    ... the Genzyme Science Award as the Fair's Grand Prize recipient for his project entitled “Curcumin Induces Apoptosis in Cancer Cells by Inhibiting NF-kB. ...

    Protect Yourself from MSG and Aspartame Excitotoxicity

    Natural News.com - ‎May 6, 2009‎

    Curcumin is the essential ingredient of turmeric. It enhances bile flow as well as DNA repair enzymes. He also recommends Taurine, an amino acid that ...

    Curcumin May Prevent Obesity

    Natural Products Industry Insider - ‎May 6, 2009‎

    BOSTON—Findings from a recent study at Tufts University suggest dietary curcumin may have a potential benefit in preventing obesity (J Nutr. ...

    Comparison of the Effects of Curcumin: first place at regional science fair

    Somerville Journal - ‎May 6, 2009‎

    Linda Chau and Lola Yu — Comparison of the Effects of Curcumin versus Chemotherapeutic Drugs, team, second place. Sarah Hassan — The Effects of Fertilizer ...

    Fight Cancer With Good Nutrition

    OpEdNews - May 1, 2009‎

    It has an active ingredient called curcumin that has shown resistance to colon, breast, liver, oral, skin, and stomach tumors in laboratory testing on ...

    Spice Up Your Diet -- And Your Health

    CBS News - ‎May 1, 2009‎

    Brain protection: Antioxidant activity of curcumin (pigment in turmeric) has been shown to be neuro-protective. Studies show may be beneficial in treatment ...

     

    Scientists unravel turmeric's healing secret

    TheMedGuru - ‎Apr 25, 2009‎

    In some previous studies, researchers have found that curcumin, a main ingredient in turmeric, contains many medicinal properties including ...

    Researchers Find Secret Behind Turmeric's Therapeutic Power

    TopNews - ‎Apr 23, 2009‎

    Whilst many researchers in recent years have conducted research on its main constituent ‘curcumin', no details had been discovered as to how curcumin works ...

    Omega-3, Curcumin Combo Reduce Inflammation

    Natural Products Industry Insider - ‎Apr 23, 2009‎

    COLLEGE STATION, Texas—Results from a study at Texas A&M University suggest combination chemotherapy (omega-3s + curcumin or limonin) may favorably modulate ...

    Steal This Health Secret: Turmeric

    Reader's Digest - ‎Apr 22, 2009‎

    Why you should try it: Small studies have found that curcumin, a component of turmeric, cuts cholesterol; animal research suggests it inhibits tumor ...

    Indian turmeric powder yields its healing secrets

    Mangalorean.com - ‎Apr 22, 2009‎

    Although modern scientific research on the spice has burgeoned in recent years, scientists until now did not know exactly how curcumin works inside the body ...

    Turmeric's secret

    Daily News & Analysis - ‎Apr 21, 2009‎

    While many scientists have conducted research on its main ingredient--curcumin--no details had been revealed as to how it functions in the body, until now. ...

    Turmeric may help reduce inflammatory bowel symptoms

    SmartBrief - ‎Apr 21, 2009‎

    Curcumin, the yellow component of the turmeric spice, reduces inflammation and might help relieve symptoms for people suffering from inflammatory bowel ...

    Curcumin May Prevent Obesity

    Natural Products Industry Insider - ‎Apr 21, 2009‎

    BOSTON—Findings from a study at Tufts University suggests dietary curcumin may have a potential benefit in preventing obesity (J Nutr. 2009;139(5):919-25). ...

    Turmeric can sooth bowel: Study

    Times of India - ‎Apr 21, 2009‎

    An international team has carried out the study and found that curcumin, the major yellow constituent of turmeric, helps in reducing inflammation in many ...

    Turmeric: India's 'Holy Powder' Finally Reveals Its Centuries-old ...

    Science Daily (press release) - ‎Apr 20, 2009‎

    Although modern scientific research on the spice has burgeoned in recent years, scientists until now did not know exactly how curcumin works inside the body ...

    Inside Out : Wheatgrass vs. hypertension, chronic fatigue / Cory ...

    Inquirer.net - ‎Apr 20, 2009‎

    ... bean sprouts, alfalfa, radish, wheatgrass, oat bran, wheat bran, rice bran, ginger, horseradish, curcumin from turmeric, capsaicin from red hot chili, ...

    Irritable bowels could be calmed with spice

    Stuff.co.nz - ‎Apr 19, 2009‎

    Researchers at Nutrigenomics New Zealand have found that curcumin, the major yellow component of the turmeric spice, reduces inflammation for those ...

    How Plants Protect Us From Disease

    Science Daily (press release) - ‎Apr 19, 2009‎

    For example, curcumin can undermine certain TLRs when a specific part of curcumin's chemical structure reacts with what are known as "sulfhydryl groups" in ...

    turmeric benefits and uses

    NewDesignWorld (press release) - ‎Apr 18, 2009‎

    One thing that all the scientists agree upon is the fact that the curcumin oil is the compound responsible for making it so bio active. ...

    Curcumin Whips Cells Into Shape

    About - News & Issues - ‎Apr 16, 2009‎

    Scientists have shed new light on how curcumin—a compound found in the curry spice turmeric—can help guard cells against all kinds of disease-promoting ...

    Curcumin and Lung Cancer

    Natural Products Industry Insider - ‎Apr 16, 2009‎

    WINSTON-SALEM, NC—According to a study published Carcinogenesis, curcumin may exhibit organ-specific effects to enhance reactive oxygen species formation in ...

    Spotlight on Joint Support

    Christian Post - ‎Apr 14, 2009‎

    Turmeric root (or curcumin), Tart cherry and Holy basil leaf (not the common herb basil) have all been used for centuries as pain-killers and ...

    Studies Reveal How Plants Protect Us from Disease

    Agricultural Research - ‎April 8, 2009‎

    For example, curcumin can undermine certain tlrs when a specific part of curcumin's chemical structure reacts with what are known as "sulfhydryl groups" in ...

    Deep in ocean

    The National - ‎Apr 3, 2009‎

    The researchers have also been working with another natural resource: curcumin, the active ingredient of turmeric. “Looking into existing living resources ...

    Plant's Mechanism of Reducing Liver Fibrosis Identified Curcumin ...

    Modern Medicine - ‎Apr 2, 2009‎

    THURSDAY, April 2 (HealthDay News) -- The ability of curcumin, an antioxidant from turmeric, to reduce liver fibrosis in patients with non-alcoholic ...

    Alternative care for breast cancer: Sheryl Crow did, should you?

    Examiner.com - ‎Mar 31, 2009‎

    These include red clover, ashwagandha, and curcumin. Broccoli sprouts contain indole-3-carbinol, a component of broccoli and other members of the Brassica ...

    Turmeric: The Mellow Yellow Healing Herb

    ColorsNW - ‎Mar 30, 2009‎

    The most widely researched alkaloids found in turmeric are the curcuminoids: curcumin, demethoxy-curcumin and bisdemethoxy-curcumin. ...

    Curry in a Hurry - The Health Benefits of Turmeric

    Brain Blogger - ‎Mar 28, 2009‎

    The active ingredient in turmeric is called curcumin. Antioxidant and free radical scavenging capacity of curcumin is on par with vitamin C and E, ...

    India: Turmeric improves health

    FreshPlaza - ‎Mar 24, 2009‎

    In a recent study conducted at Michigan University, it was found that curcumin, the bright yellow pigment present in turmeric, can help boost cell health by ...

    5 Spices for Better Health

    Reader's Digest - ‎Mar 22, 2009‎

    Because of its anti-inflammatory properties, scientists are studying curcumin, one of the most active substances in turmeric, as a possible treatment for ...

    One for the ages

    Boston Globe - ‎Mar 22, 2009‎

    The resveratrol phenomenon has created a "parallel interest in other substances, such as curcumin," said Douglas MacKay, a licensed naturopathic doctor in ...

    Food that heals

    DL-Online - ‎Mar 20, 2009‎

    Turmeric, whose active ingredient is curcumin, is most effective when combined with black pepper and olive oil during cooking. ...

    Why an Indian is good for the brain and how chillies relieve ...

    The Sun - ‎Mar 18, 2009‎

    American research revealed in 2006 that curcumin, a chemical found in curry ingredient turmeric, may help the body clear the protein that causes the brain ...

    Super spices

    The Canberra Times - ‎Mar 17, 2009‎

    Turmeric - a vivid yellow spice which adds colour and antioxidants due to its curcumin with research showing it may delay dementia. ...

    Alzheimer's: Prevent It With Nutrition?

    Depok Metro - ‎Mar 17, 2009‎

    Dr. Whitaker suggests a daily supplement regimen: DHA, 50 mg (3-4 fish oil capsules); Curcumin, 900-1800 mg; Natural vitamin E,800-1600 IU; Vitamin C,3000 ...

    7 Super Spices: Herbs for a healthy heart

    Manila Bulletin - ‎Mar 16, 2009‎

    Evidence suggests that curcumin, the bright yellow compound in turmeric, may help inhibit the growth of cancer cells, reduce inflammation, and safeguard the ...

    The spicy disciplinarian

    spectroscopyNOW.com - ‎Mar 14, 2009‎

    Solid state NMR has been used to help to explain why curcumin, one of the physiologically active components of the yellow spice turmeric has wound healing ...

    Turmeric Ingredient Makes Membranes Behave For Better Health

    sScienceDaily.com - ‎Mar 8, 2009‎

    University of Michigan researchers led by Ayyalusamy Ramamoorthy have discovered that curcumin acts as a disciplinarian, inserting itself into cell membranes and making them more orderly, a move that improves cells' resistance to infection and malignancy.

    Spice Route

    Best Life  Magazine - ‎Mar 5, 2009‎

    Curcumin, a chemical in turmeric, helps deter the accumulation of amyloid plaques in the brain, tiny blockages that may cause Alzheimers disease ...

    The People's Pharmacy

    Seattle Times - ‎Mar 2, 2009‎

    A component, curcumin, has powerful anti-inflammatory activity, and, preliminary studies suggest, some benefit for psoriasis. One reader wrote: "I took ...

    Alzheimer's: Prevent It With Nutrition?

    Feb 26, 2009‎

    Dr. Whitaker suggests a daily supplement regimen: DHA, 50 mg (3-4 fish oil capsules); Curcumin, 900-1800

    Natural ways to reduce cancers include anti-oxidants, supplements

    Tulsa World - ‎Feb 21, 2009‎

    These include rosemary, broccoli, olives, ground flaxseed, probiotics, cat's claw, curcumin, omega 3 fatty acids, ginger, N-acetylcysteine, spirulina and ...

    What's hot about curry?
    University Daily Kansan, KS - Feb 4, 2009 
    She says many studies found anti-inflammatory and anti-cancer properties in curcumin, a substance found in turmeric. Curry addicts anonymous: Vaishali Gala, ...
    5 Reasons I Wish I Liked Turmeric
    Beliefnet.com, NY - Feb 4, 2009 
    The curcumin in turmeric (the thing that gives it its orange-yellow color) may have powerful anti-inflammatory and anti-cancer properties (see this article) ...
    Curry some flavor to reduce inflammation
    Pioneer Press Online, IL - Jan 29, 2009 
    The key Alzheimer's-fighting spice in curry powder is turmeric, whose main chemical is curcumin. A pigment in curcumin gives turmeric its yellow color. ...
    Pancreatic Cancer, Tumeric and Omega-3
    Cancer Monthly, NC - Jan 25, 2009
    A recent study in the journal Nutrition and Cancer finds that curcumin—a compound in turmeric—halts the growth of pancreatic cancer, particularly when ...
    Tailoring autism therapies
    Worcester Telegram, MA - Jan 25, 2009 
    He also uses a glutathione cream that is supposed to detoxify his body, a B-12 cream, an intestinal complex to help with digestion, fish oils, curcumin and ...
    The You Docs tips for the week
    Telegraph-Journal, Canada - Jan 24, 2009 
    The food: Curry The magic: Curcumin, a substance found in the Indian spice turmeric, may help quell the muscle inflammation that you know as next-day ...
    Natural Help for Ovarian Cancer
    Natural News.com, AZ - Jan 23, 2009 
    Tumeric (found in the common spice Curcumin) has been shown to be effective against a wide variety of cancers, including ovarian, and is meriting more and ...
    Are your painkillers killing you?
    phillyBurbs.com, PA - Jan 21, 2009 
    Curcumin, found in turmeric, is another natural compound that reduces inflammation. You can sprinkle it on a variety of foods or get it in supplement form. ...
    Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A ...
    SmartBrief, DC - Jan 21, 2009 
    Want to dig deeper? SmartBrief brings you news, research, and other information related to this issue. To track this topic, bookmark the page and return for ...
    New Book by Harvard-trained MD Explains How to 'Prevent Cancer ...
    PR Web (press release), WA - Jan 21, 2009 
    World wide research indicates that Curcumin, the active ingredient in turmeric, is very effective in controlling inflammation. At least a dozen clinical ...
    Food secrets for staying slim
    Trinidad News, Trinidad and Tobago - Jan 20, 2009 
    When they fed obese mice curcumin, the yellow-orange antioxidant in turmeric, there was a decline in the animals’ body weight and fat, even with higher ...
    Here's a brainy idea - how about a little music?
    Toronto Star,  Canada - Jan 20, 2009 
    The magic: Curcumin, a substance found in the Indian spice turmeric, may help quell the muscle inflammation that you know as next-day stiffness and soreness ...
    Trying Anything and Everything for Autism
    New York Times, United States - Jan 20, 2008
    He also uses a glutathione cream that is supposed to detoxify his body, a B-12 cream, an intestinal complex to help with digestion, fish oils, curcumin and ...
    Spice It Up with Ground Realities
    TheMedGuru, India - Jan 18, 2009 
    Curcumin is the compound present in Turmeric, which lends the spice its yellow color. This active compound is believed to assist body in fighting against ...
    Medical management of NMSCs
    Modern Medicine, NJ - Jan 18, 2009 
    Down the road, dermatologists can expect to see curcumin, lycopene, T4 endonuclease, cox-2 inhibitors, DFMO and polyphenolic antioxidants added to this ...
    The You Docs: Hard workout? Foods that stop the soreness
    Seattle Post Intelligencer - Jan 18, 2009 
    The magic: Curcumin, a substance found in the Indian spice turmeric, may help quell the muscle inflammation that you know as next-day stiffness and soreness ...
    Nutrition Wise: Turmeric, Free Range Chicken, Citrus Fruits and ...
    Kansas City infoZine, MO - Jan 18, 2009 
    A: There is laboratory evidence to suggest that curcumin, the compound that gives turmeric its yellow color, might reduce formation or growth of cancer ...
    Fruits and Vegetables in Cancer Prevention
    Insciences Organisation, Switzerland - Jan 16, 2009
    Evidence indicates that some food compounds, such as soy isoflavones and curcumin, can increase the effectiveness of chemotherapy and radiation therapy. ...
    Evidence Update
    ADVANCE for LPNs, PA - Jan 15, 2009
    ... such as antioxidants and vitamin B complex (especially folate), omega-3 polyunsaturated fatty acids, the polyphenol curcumin and other nutraceuticals. ...
    Today’s Foods May Be Tomorrow’s Medicines
    Food Product Design, IL - Jan 15, 2009 
    A single plant molecule can have an array of health-promoting effects, Curcumin, obtained from the spice turmeric, not only protects against cancer but is ...
    Herbs and Spices Boost Health
    NewsMax.com, FL - Jan 15, 2009 
    The active ingredient in turmeric, curcumin, is an extremely powerful anti-inflammatory substance. It may play a role in combating cancer and reducing the ...
    The cures in your kitchen
    New Zealand Herald, New Zealand - Jan 12, 2009 
    A single plant molecule can have a bewildering array of health-promoting effects - curcumin, for example, obtained from the spice turmeric, doesn't only ...
    Eat antioxidants
    USA Today - Jan 12, 2009 
    Piles of evidence show that antioxidant-packed spinach, broccoli, pomegranate juice, dark chocolate, garlic, onions, tea, coffee, purple grapes, red wine and the spice turmeric cut disease risk. ...
    Turmeric helpful in anti-cancer drugs
    Times of India, India - Jan 8, 2009 
    Series of researches conducted in the last five years by MS University's pharmacy department on animals have revealed that green tea leaf and curcumin help ...
    : The Top 10 Health Breakthroughs of 2008
    NewsReleaseWire.com (press release) - Jan 6, 2009
    This year scientists demonstrated that fish oil, blueberries, curcumin, and pantethine all help boost the production of BDNF. Running is now proven to be ...
    STEVE JOBS' WASTING-AWAY HEALTH PROBLEM
    NewsWithViews.com, OR - Jan 5, 2009
    Top choices include grape seed extract, fish oil, bromelain, papain, curcumin, quercetin, silymarin, and r-alpha lipoic acid. These nutrients not only help ...
    Turmeric Boots The Brain
    Bottom Line Health Secrets - Dec 27, 2008
    Curcumin (turmeric’s active ingredient) is one of the most potent, naturally occurring anti-inflammatory agents ever identified and thus may be one of the best all-round spices for disease protection and antiaging. 
    Alzheimer's: Prevent It With Nutrition?
    PWO, France - Dec 27, 2008
    Dr. Whitaker suggests a daily supplement regimen: DHA, 50 mg (3-4 fish oil capsules); Curcumin, 900-1800 mg; Natural vitamin E,800-1600 IU; Vitamin C,3000 ...
    Science says it's possible to regenerate your brain
    Ethiopian Review, DC - Dec 26, 2008
    Turmeric, typically found in curry, contains curcumin, a chemical with potent antioxidant and anti-inflammatory properties. In India, it is even used as a ...
    Haldi or turmeric, a popular Indian spice may help in defeating ...
    TopNews, India - Dec 20, 2008
    Presently curcumin found in turmeric is being researched as possible cure for Alzheimer’s. Researchers at the University of Southampton believe that ...
    Curry link to beating Alzheimer's Disease discovered by ...
    this is hampshire.net, UK - Dec 20, 2008
    A study will look in to whether curcumin – found in turmeric – can help prevent the debilitating disease. It means spice lovers would be able to enjoy any ...
    Turmeric may work for Alzheimer’s
    Times of India, India - Dec 18, 2008
    Researchers at the University of Southampton are investigating whether curcumin found in turmeric — that gives curries the yellow colour — could benefit ...
    Curry 'linked to Alzheimer's treatment'
    Barchester Healthcare, UK - Dec 18, 2008
    The Alzheimer's Society is investigating the effects of curcumin - a component of turmeric, a popular Indian spice - on those with the disease. ...
    Alzheimer’s Society
    Look To The Stars, UK - Dec 17, 2008
    In over 250 locations across the UK, Alzheimer’s Society staff and volunteers work together to provide help and information to people affected by dementia ...
    Cooking, chemistry combine in the SU honors kitchen
    Bethany Beach Wave, DE - Dec 17, 2008 - Filter
    ... the yellow spice turmeric, has been definitively associated with lower levels of Alzheimer’s in India because of the component curcumin in the turmeric. ...
    Turmeric may lower blood pressure
    Indianapolis Star, United States - Dec 15, 2008
    Answer: Rodent research suggests that curcumin, the active ingredient in turmeric, can lower blood pressure (Journal of Clinical Investigation, March 2008). ...
    People's Pharmacy: Help for fungal infections
    Houston Chronicle, United States - Dec 14, 2008
    We don’t think doctors will prescribe curry, but rodent research suggests that curcumin, the active ingredient in turmeric, can lower blood pressure ...
    Golden therapy
    Hindu, India - Dec 13, 2008
    Low rates of Alzheimer’s among rural Indians first drew the attention of western researchers to curcumin. The most likely reason for this dramatic ...
    Curcumin an Effective Anticancer Agent
    PR Urgent - Dec 13, 2008
    Curcumin is derived from turmeric fingers. Curcumin act as a powerful antioxidant, anti tumors, anti inflammatory agent etc keeps the body away from disease ...
    Feed the Immune System for the Cold and Flu Season
    Imperial Valley News, CA - Dec 9, 2008
    Turmeric is found in every yellow curry, and its golden color is the result of curcumin, a polyphenol with strong cold and flu-fighting properties. ...
    Curry Treats Parkinson’s Disease
    NewsMax.com, FL - Dec 1, 2008
    Researchers at Johns Hopkins Medicine have found that curcumin, the spice used in curries, eases the symptoms of Parkinson’s disease. ...
    Fruits and Vegetables Regulate the Cell Cycle to Prevent Cancer
    Natural News.com, AZ - Nov 30, 2008
    Compounds from fruits and vegetables that appeared particularly noteworthy were apigenin (celery, parsley), curcumin (turmeric), epigallocatechin-3-gallate ...
    FOUR AGGRESSIVE APPROACHES TO WARDING OFF CANCER
    NewsWithViews.com, OR - Nov 29, 2008 
    The most effective are flavonoids found in broccoli; whey isolate; B-17 from the apricot seed; and curcumin. ...
    Practical Prevention: Add a Little Spice to Your Life
    Kitsap Sun,  United States - Nov 23, 2008
    Providing the main color and flavor of curry, turmeric contains a potent antioxidant and anti-inflammatory called curcumin. Studies suggest that curcumin ...
    How to prevent Alzheimer’s disease – part 1
    Food Consumer, IL - Nov 21, 2008
    Spice your food with curry: Curcumin, a component of curry and turmeric, seems to help the immune system get rid of amyloid beta -- the protein that builds ...
    Researchers Find Natural Help for Arthritis and Parkinson's ...
    Natural News.com, AZ - Nov 20, 2008
    And curcumin, derived from the curry spice turmeric, has long been known to be a powerful antioxidant with anti-inflammatory properties. ...
    Curcumin Health Benefits: Curcumin May Ease Depression
    Stop Aging Now, DC - Nov 19, 2008
    Turmeric contains curcumin, an antioxidant compound known to have anti-inflammatory and other health promoting properties. A recent study in India showed ...
    How To Keep Yourself Safe From Arsenic In Your Environment
    Natural News.com, AZ - Nov 18, 2008
    (NaturalNews) Curcumin, the active ingredient in the spice turmeric is effective against the harmful impact of arsenic according to a recent study reported ...
    Cancer survivor credits healthful diet
    Denver Post, CO - Nov 16, 2008
    "But if you take the phytochemical curcumin found in the Indian spice turmeric — which hits over 70 targets — you might get different results," Block said. ...
    Eat it: 6 foods that ward off aging
    Lansing State Journal, MI - Nov 16, 2008 - Filter
    Curry powder: It's full of the antioxidant curcumin, which wards off Alzheimer's disease by preventing the growth of amyloid plaques, which are toxic to ...
    Cole's team identified another nutrient that appears to combat Alzheimer's plaques in mice: curcumin
    SheKnows.com, AZ - Nov 4, 2008
    Last year, Cole's team identified another nutrient that appears to combat Alzheimer's plaques in mice: curcumin, the yellow pigment in turmeric, ...
    Want to Avoid Alzheimer’s?
    NBC Washington, DC - Nov 3, 2008
    The UCLA group hypothesized that curcumin, a chemical in turmeric, might clean up or block the buildup of amyloid plaques, which scientists believe may ...
    Curcumin has anti-inflammatory properties and is a preventive for Alzheimer’s, cancer and artherosclerosis.
    Inquirer.net, Philippines - Nov 3, 2008
    Melatonin keeps you young and boosts the immune ...
    Add spice, reap benefits
    The Daily Evergreen, WA - Nov 2, 2008
    Studies have linked consumption of curcumin, the active ingredient in tumeric, to benefits ranging from preventing heart failure to slowing the progression ...
    Eat Smart Add turmeric to your food
    USA Weekend - Oct 31, 2008
    Turmeric contains curcumin, a powerful antioxidant dubbed "curecumin" by leading researcher Bharat Aggarwal of the University of Texas MD Anderson Cancer ...
    Turmeric Reduces Size of Stroke
    India Journal, CA - Oct 30, 2008
    Scientists at the US-based Medical College of Georgia are using animal models to study effects of turmeric or curcumin on intracerebral haemorrhages. ...
    Ten immune system-boosting foods
    abc13.com, TX - Oct 30, 2008
    Turmeric is found in every yellow curry and its golden color is primarily the result of curcumin, a polyphenol with strong cold and flu-fighting properties. ...
    Study Shows Turmeric May Prevent Type 2 Diabetes
    Natural News.com, AZ - Oct 29, 2008
    The effect is believed to come from curcumin, a key ingredient in turmeric that is known to function as an antioxidant and anti-inflammatory. ...
    Spice In Indian Food May Help Fight Cancer
    WJZ, MD - Oct 28, 2008
    Healthwatch reporter Kellye Lynn talked to a researcher at Johns Hopkins who says curcumin could slow the spread of cancer. Scientists in Baltimore are ...
    Fresh cancer treatment
    Sunshine Coast Daily, Australia - Oct 25, 2008
    But if you take the phytochemical curcumin found in the Indian spice turmeric – which hits more than 70 targets – you might get different results. ...
    The D.E.A.R. Program: Four Step Anti-Alzheimer’s Method
    Vincent Fortanasce, M.D. - Oct 25, 2008
    Curcumin, a component of the spice turmeric, is a potent antioxidant with anti-inflammatory effects.. ...
    Pioneer stem cell patient is 'quite well'
    Honolulu Star-Bulletin, HI - Oct 25, 2008
    She also takes an herb known as macuna pruriens and has found that curcumin (turmeric) is a great help. ...
    NIH Botanical Center Research Update
    Natural Products Industry Insider, AZ - Oct 24, 2008
    ... outlined his team's the focus and goals relative to five botanicals—Echinacea, astragalus, curcumin, coriolus mushroom and maitake mushroom. ...
    Spice up your immune system
    The Silhouette, Canada - Oct 23, 2008
    In recent years, curcumin, the active component of turmeric, has been highly studied for its incredible medicinal and healing properties. ...
    Our Favorite Winter Squashes
    Stop Aging Now, DC - Oct 22, 2008
    This Curried Butternut Soup recipe has anti-inflammatory, brain-protecting curcumin in the curry powder, lots of antioxidant beta-carotene and good amounts ...
    Curry Cuisine
    Trinidad News, Trinidad and Tobago - Oct 22, 2008
    Many people with arthritis take over-the-counter supplements that contain curcumin, the active ingredient in turmeric. Curry also may offer some protection ...
    The Fabulous Five: Compounds Found Most Effective Against Cancer
    Natural News.com, AZ - Oct 21, 2008
    Among those that are proving to be the front line of defense against an initial diagnosis of cancer and to prevent recurrence are DIM, curcumin, EGCG, ...
    6 foods that ward off aging
    Kansas City Star, MO - Oct 20, 2008
    •Curry powder: It’s full of the antioxidant curcumin, which wards off Alzheimer’s disease by preventing the growth of amyloid plaques, which are toxic to ...
    Naturally Improved Health and Well-being with Nordic Superfruit ...
    NPIcenter (press release), Canada - Oct 20, 2008
    ... Red Grape Polyphenols, White Grape Polyphenols, Red Cabbage Polyphenols, Blackcurrant Polyphenols, Cranberry Polyphenols, Curcumin, and Chlorophyllin. ...
    The quest for cancer-preventing drugs
    Los Angeles Times, CA - Oct 20, 2008
    Folic acid, vitamin D, selenium, lycopene, the spice ingredient curcumin, green tea and resveratrol, a compound found in red grapes, all are being tested in ...
    Some pain may be manageable using herbal solutions
    Fort Worth Star Telegram, TX - Oct 19, 2008
    Turmeric (a curry ingredient) may be the best: A component of it, curcumin, eases inflammatory conditions like rheumatoid arthritis and psoriasis, ...
    Having a problem? Check your kitchen
    Sunday Times.lk, Sri Lanka - Oct 18, 2008
    Turmeric contains a compound called curcumin which is a powerful anti-inflammatory as well as antioxidant. Today, investigators at the University of ...
    Spice extract may help stroke victims
    LubbockOnline.com, TX - Oct 14, 2008
    Curcumin is the plant chemical that makes the spice tumeric yellow, and tumeric is a frequent ingredient in curry powder. It is also the focus of stroke ...
    Decreasing belly fat
    Examiner.com - Oct 13, 2008
    -Turmeric is a ginger-like plant with the active ingredient of curcumin which helps to reduce weight gain. Turmeric can be found in beverages, ice cream, ...
    An Anticancer Diet
    Daily News Central, NV - Oct 12, 2008
    ... turmeric (one of the main spices in curry) has been found to contain the most potent natural antiinflammatory ever described -- the molecule "curcumin. ...
    Protect all your vital organs
    The Post, Pakistan - Oct 11, 2008
    Lab experiments in the past have shown that curcumin - the yellowish component of the Indian curry spice turmeric - is able to fight skin, breast and other ...
    Turmeric can prevent diabetes-induced blindness
    Hindu, India - Oct 10, 2008
    Lab experiments in the past have shown that curcumin - the yellowish component of the Indian curry spice turmeric - is able to fight skin, breast and other ...
    Regulations and Processing Decimating Consumer Health, Researchers ...
    Food Ingredients First, Netherlands - Oct 8, 2008
    He pointed to ingredients such as curcumin and specific probiotics like Lactobacillus Paracasei as well as glutathione rich foods like brocolli as promoting ...
    Turmeric may Reduce Hemorrhagic Stroke Size
    Medi News Direct, India - Oct 7, 2008
    Curcumin, a principal component responsible for the yellow color in the Indian spice turmeric, has been previously suggested to possess anticancer ...
    Feeding your body's defenses against cancer
    Daily Camera, CO - Oct 6, 2008
    "But if you take the phytochemical curcumin found in the Indian spice turmeric -- which hits over 70 targets -- you might get different results," Block said ...
    Anti cancer effects of curcumin: Cycle of life and death
    7thSpace Interactive, NY - Oct 3, 2008
    In this respect, cell cycle regulation and its modulation by curcumin are gaining widespread attention in recent years. Extensive research has addressed the ...
    Breast Cancer Prevention News: Antioxidants Decrease Breast Cancer ...
    Stop Aging Now, DC - Oct 2, 2008
    Research has shown that the antioxidant curcumin, found in turmeric, may be protective against breast cancer. Eat an anti-inflammatory diet, rich in plants, ...
    Foods to keep us all going strong
    Philadelphia Daily News, PA - Oct 2, 2008
    _ Double dose of spice: Turmeric contains a compound called curcumin that may help keep the brain young. Turmeric also may improve memory. ...
    In Cancer Scare Story, Medical Researchers Admit Vitamin C ...
    Natural News.com, AZ - Oct 1, 2008
    ... Chaparral, Curcumin (turmeric), Resveratrol and numerous others. Sunshine is anti-cancer. Raw foods are anti-cancer. Rainforest herbs are anti-cancer. ...
    Take Care of Chronic Obstructive Pulmonary Disease Naturally
    The Healthier Life - Sep 26, 2008
    Antioxidant and/or anti-inflammatory agents such as curcumin (a principal component of turmeric), resveratrol (a flavanoid found in red grapes) and green ...
    Turmeric Can Help In Reducing The Size Of Hemorrhagic Stroke
    United Press International - Sep 25, 2008
    The spice turmeric lowers the risk of getting cancer and Alzheimer's disease and it may reduce the size of a stroke as well ...
    Study Finds Cancer Survivors' Health Greatly Enhanced With Vitamin ...
    Natural News.com, AZ - Sep 23, 2008
    One cancer survivor I know would add DIM, beta glucan, vitamin C complex, vitamin D3, niacin, magnesium, curcumin, tocotrienols, sulforaphane and quercetin ...
    NF-kappa B Mediates the Survival of Human Bronchial Epithelial ...
    7thSpace Interactive (press release), NY - Sep 23, 2008 
    Methods: Both the pharmacologic inhibitor of NF-kappaB, curcumin, and RNA interference targeting p65 were used to block NF-kappaB signaling in HBECs. ...
    Turmeric Helps Reduce Size of Haemorrhagic Stroke
    TheMedGuru - Sep 23, 2008
    "We found that curcumin significantly decreases the size of a blood clot, but we're not sure why it happens" McCracken said adding that thy think it may be ...
    6 foods that ward off aging
    Dallas Morning News, TX - Sep 23, 2008
    Curry powder: It's full of the antioxidant curcumin, which wards off Alzheimer's disease by preventing the growth of amyloid plaques, which are toxic to ...
    Indian Spice In Turmeric Reduces Size Of Hemorrhagic Stroke
    Science Daily - Sep 22, 2008
    "We found that curcumin significantly decreases the size of a blood clot, but we're not sure why it happens," says the Alpharetta native. ...
    Yerba Mate: South America's Health Drink
    Natural News.com, AZ - Sep 21, 2008
    Other compounds that inhibit angiogenesis and are active as chemopreventive agents, such as curcumin, also inhibit proteasome activity. ...
    Editorial: Cancer demands our attention
    Shreveport Times, LA - Sep 19, 2008
    It includes Dr. Shile Huang who received $720000 from the American Cancer Society for research into the spice curcumin and its potential as an anti-cancer ...
    Turmeric Shows Promise in Combating Diabetes and Obesity
    Natural News.com, AZ - Sep 17, 2008
    They speculate that curcumin, the anti-inflammatory, anti-oxidant ingredient in turmeric, lessens insulin resistance and prevents Type 2 diabetes in these ...
    Recent advances in the investigation of curcuminoids
    7thSpace Interactive , NY - Sep 17, 2008
    Curcumin is the most important constituent among natural curcuminoids found in these plants. Published research has described the biological effects and ...
    Crystalline Compound Found in Asian Medicine, Cuisine Shown to be ...
    innovations report (Pressemitteilung), Germany - Sep 15, 2008
    A collaborative team of scientists from the Uniformed Services University of the Health Sciences (USU) will have a study of the effects of curcumin in ...
    Foods That Prevent Cancer - An Interview With Mike Adams
    Natural News.com, AZ - Sep 13, 2008
    Did you know that there's an active ingredient in turmeric, which is an ingredient in curry, called curcumin? Curcumin causes cancer tumors to be unable to ...
    Food for thought
    Scugog Standard Newspaper, Canada - Sep 12, 2008
    The active ingredient in turmeric is ‘curcumin,’ which has been shown to inhibit and slow cancer growth. It is a powerful anti-oxidant, ...
    Turmeric improves flavor and health
    Suffolk News-Herald, VA - Sep 10, 2008
    I learned that Turmeric is the yellow spice in mustard and curry and that its active ingredient is curcumin. It usually can be found on spice shelves in ...
    Go on, spice up your life -- you'll like it
    Orlando Sentinel, FL - Sep 9, 2008
    A: Turmeric is a spice found in curry powder that gets its yellow color from a pigment called curcumin. In fact, says the IFIC, curcumin is used as a spice ...
    Painkiller on Your Kitchen Shelf
    RedOrbit, TX - Sep 7, 2008
    In fact, curcumin has been found to be every bit as effective as the pharmaceutical drugs cortisone and phenylbutazone in clinical trials. ...
    Cure cancer with diet?
    SheKnows.com, AZ - Sep 7, 2008
    ... turmeric (one of the main spices in curry) has been found to contain the most potent natural anti-inflammatory ever described – the molecule "curcumin". ...
    Curcumin, a compound in the spice turmeric, temporarily stopped advanced pancreatic cancer growth in two patients and substantially reduced the size of a tumor in another patient...
    CancerWise - Sep 5, 2008 
    By Darcy De Leon Curcumin, a compound in the spice turmeric, temporarily stopped advanced pancreatic cancer growth in two patients and substantially reduced ...
    Van Andel Institute researchers discover common spice blocks cold ...
    Rapid Growth, MI - Sep 2, 2008  
    Van Andel Institute scientists have discovered that curcumin, a component of turmeric, blocks the herpes simplex viral infections. ...
    Feeding your body's defenses against cancer
    PhysOrg.com, VA - Sep 2, 2008
    "But if you take the phytochemical curcumin found in the Indian spice turmeric - which hits over 70 targets - you might get different results," Block said. ...
    Turmeric May Help Reduce Type 2 Diabetes Risk
    ABC News - Sep 1, 2008
    In obese mice, turmeric significantly reduced inflammation in fat tissue and the liver and reduced the rodents' susceptibility to type 2 diabetes. The researchers believe curcumin -- an ingredient in turmeric -- may be responsible ...
    Curry Ingredient May Cut Cardiovascular Risks
    ABC News - Sep 1, 2008
    Curcumin, an ingredient in the curry spice tumeric, can reduce heart enlargement and may lower the risk of heart failure ...
    Taking care before and after surgery
    North Island Midweek, Canada - Sep 1, 2008 
    Another remedy I use with good success is a natural anti-inflammatory composed of a mixture of bromelain, curcumin and quercitin. ...
    Reverse aging
    Delicious Living Magazine, Coloarado - Sep 1, 2008  
    Curcumin, a naturally occurring chemical in the spice, slows down the aging process by fighting inflammation-causing proteins called cytokines. ...
    Coast to Coast AM George Noory Interviews Christian Wilde About Turmeric and Curcumin
    Coast To Coast AM with George Noory September 2008
    Researcher Christian Wilde discussed new studies on turmeric, which showed that the spice may reduce the size of a stroke and lower the risk of getting cancer...
    Spices add a dash of health to dishes
    Chicago Tribune, United States - Aug 31, 2008 
    ... curry powder is a blend of turmeric and other spices. Curcumin, the bright yellow pigment in turmeric, helps fight heart disease and may boost brain health.
    Turmeric: The Salt of the Orients is the Spice of Life
    RedOrbit, TX - Aug 26, 2008
    Major attention has centered round curcumin and related curcuminoids which constitute 2-5 per cent of the biomass of the rhizome and are responsible for its ...
    A-to-Z Buyer's Guide
    RedOrbit, TX - Aug 26, 2008
    The active ingredient in the herb is curcumin. Some supplements contain turmeric while others contain curcumin, extracted from the whole herb. ...
    Fruits and Vegetables Modulate the Cell Cycle to Prevent Cancer
    Natural News.com, AZ - Aug 22, 2008
    Compounds from fruits and vegetables that appeared particularly noteworthy were apigenin (celery, parsley), curcumin (turmeric), epigallocatechin-3-gallate ...
    Alzheimer's: Prevent It With Nutrition?
    Corsavoo.com, France - Aug 20, 2008
    Dr. Whitaker suggests a daily supplement regimen: DHA, 50 mg (3-4 fish oil capsules); Curcumin, 900-1800 mg; Natural vitamin E,800-1600 IU; Vitamin C,3000 ...
    Spice-based compound may kill cancer cells
    United Press International - Aug 18, 2008
    Assistant Professor James Fuchs said the synthetic molecules are derived from curcumin, a naturally occurring compound found in the spice turmeric. ...
    One woman's battle with the effects of salmonella
    MetroWest Daily News, MA - Aug 15, 2008
    Researchers, the broadcast said, have discovered turmeric - the spice that gives curry its distinctive yellow tint - contains curcumin, a natural ...
    On nutrition: Spice up your life
    The Olympian, WA - Aug 15, 2008
    A: Turmeric is a spice found in curry powder that gets its yellow color from a pigment called curcumin. In fact, says the IFIC, curcumin is used as a spice ...
    Prevent Memory Loss with Diet
    Stop Aging Now, DC - Aug 13, 2008
    Those with the strongest supporting evidence: green tea, fish oil, gingko, alpha lipoic acid, curcumin, and acetyl-l-carnitine. The Anti-Aging Bottom Line: ...
    A curry could help boost your memory, and prevent Alzheimers
    Daily Mail, UK - Aug 11, 2008
    By Daily Mail Reporter Curcumin, a key ingredient of the spice turmeric, is good for the memory - and now scientists know why. It has been shown to protect ...
    Wellness in a Minute: Benefits of antioxidants
    The Evening Sun, PA - Aug 10, 2008
    The main ingredient in curry is turmeric, from which a spice called curcumin is derived. Sally Frautschy, Ph.D., a researcher from UCLA who has done ...
    Breast cancer: What you need to know
    Food Consumer, IL - Aug 5, 2008
    Turmeric: Curcumin in turmeric, a yellow spice widely used in Indian cuisine, has long been touted for its health benefits. A study recently found that ...
    Many herbs make move to medicine cabinet
    MLive.com, MI - Aug 5, 2008
    Turmeric, the spice that gives curry powder its yellow color, has an active ingredient called curcumin, which appears to inhibit enzymes that lead to ...
    Growth Inhibition of Human Colon Cancer Cells By Plant Compounds
    RedOrbit, TX - Aug 1, 2008
    For example, it dramatically increases absorbency of curcumin (a component of the spice turmeric).15 Since few studies have been reported assessing direct ...
    Good News About Curry
    13WHAM-TV, NY - Jul 31, 2008
    Curcumin, the natural yellow pigment in curry, has been shown to improve symptoms of diabetes in mice. Researchers say they noticed a significant drop in ...
    A Spicy Diet May Help Diabetics
    Christian Broadcasting Network, VA - Jul 31, 2008
    "After two weeks of consuming curcumin orally, their diabetes was essentially gone." The results suggested that curcumin, which is found in turmeric, ...
    Researchers: Diabetics should 'spice' up diets
    NECN, MA - Jul 31, 2008
    They then added a high dose of turmeric's pigment, called curcumin, to the same diet of half the mice. The "spice mice" lost only a little weight, ...
    Curry spice flavors UAB fight against pancreatic cancer
    The Birmingham News - al.com, AL - Jul 31, 2008
    UAB researchers are seriously exploring the possibility that curcumin, which is found naturally in this spice, may inhibit the growth of pancreatic cancer ...
    Oprah Winfrey Show
    Oprah.com - July, 2008
    Dr. Mehmet Oz says the secret to good mental health may be on Indian spice racks. "The reason we think they have a lower instance of Alzheimer's isthey use a lot of turmeric in their food," he says. Turmeric is an orange-yellow spice that's commonly used to make curries. Its active ingredient is called curcumin. ...
    Food for thought
    Economist.com - July, 2008
    Another polyphenol, curcumin, has also been shown to have protective effects. It reduces memory deficits in animals with brain damage. It may be no coincidence that in India, where a lot of curcumin is consumed (it is the substance that makes turmeric yellow), Alzheimer’s disease is rarer than elsewhere. ...
    Curcumin shows promise as a natural cancer treatment
    Chicago Daily Herald, IL - July, 2008
    By Dr. Patrick Massey | Daily Herald Columnist Is possible that the first natural anticancer therapy may be curcumin, a spice from India? ...
    Turmeric may help prevent type 2 diabetes
    Food Consumer, IL - Jul 27, 2008
    They speculate that curcumin found in turmeric may be the active ingredient that lessens insulin resistance and prevents type 2 diabetes in the mice by ...
    YourHealth: Fat head and the fishy truth
    New Straits Times, Malaysia - Jul 26, 2008
    Omega-3 fatty acids as well as curcumin, a compound present in the spice turmeric, can help elevate BDNF in a manner similar to antidepressant or ...
    Cognition nutrition Food for thought
    Economist, UK - Jul 17, 2008
    Another polyphenol, curcumin, has also been shown to have protective effects. It reduces memory deficits in animals with brain damage. ...
    Tobacco Researchers in Oklahoma Receive Grants
    RedOrbit, TX - Jul 16, 2008
    ... of biochemistry and molecular biology at Oklahoma State University, Expression Profile of MicroRNAs in Cells Treated with Cigarette Smoke and Curcumin.
    UA researcher probes potential for plants' power in medicine
    FreshPlaza, Netherlands - Jul 15, 2008
    Scientists have isolated the main active ingredient in turmeric, curcumin, but Gang is also interested in two other compounds found in the rhizome of ...
    Eating Healthy Food Can Keep Mental Disorders At Bay!
    TheMedGuru, India - Jul 12, 2008
    Adding more of curcumin (principle curcuminoid of the Indian curry spice turmeric) in one’s food can help prevent Alzheimer''s disease and brain trauma. ...
    Curry ingredient fights skin cancer
    Online - International News Network, Pakistan - Jul 12, 2008
    They said curcumin, found in the spice turmeric, interferes with melanoma cells. Tests in laboratory dishes show that curcumin made melanoma skin cancer ...
    The You Docs tips for the week
    Telegraph-Journal, Canada - Jul 12, 2008
    Curcumin, a compound in turmeric, shows promise against cystic fibrosis, colon cancer, arthritis, Alzheimer's... and even the discomfort of post-workout ...
    Fight Diabetes with Curcumin
    Stop Aging Now, DC - Jul 11, 2008
    By Carey Rossi A recent study found that diabetics who supplemented with curcumin for six weeks experienced significant improvements in insulin resistance ...
    Balanced Diet Helps Maintain
    Oneindia, India - Jul 11, 2008
    The researcher also said that the high consumption of curcumin, found in the India curry spice turmeric, might help prevent Alzheimer''s disease and brain ...
    Scientists Learn How Food Affects The Brain: Omega 3 Especially ...
    Science Daily (press release) - Jul 9, 2008
    Here, too, omega-3 fatty acids are beneficial, as is the curry spice curcumin, which has been shown to reduce memory deficits in animal models of ...
    Turmeric packs surprisingly flavourful punch
    Times Colonist, Canada - Jul 9, 2008
    According to an article in the Wall Street Journal titled Common Indian Spice Stirs Hope, research into curcumin, the active ingredient in turmeric, ...
    Clams we dig
    Daytona Beach News-Journal, FL - Jul 8, 2008
    At a dinner last month at the restaurant to unveil the recipe, DeSilva praised the active ingredient in the spice, curcumin, as an anti-inflammatory, ...
    Fresh Fat Facts
    Keep the Doctor Away, UK - Jul 8, 2008
    ... makes you less susceptible to developing Type 2 diabetes – probably because of curcumin, an anti-inflammatory, anti-oxidant ingredient in turmeric. ...
    Sheriff takes to the saddle for Hope
    Melton Today, UK - Jul 5, 2008
    Projects Hope has funded include investigations into the preventative effects of food derivatives such as berries, curcumin, rice bran and tea; ...
    Spice up your health with turmeric
    SheKnows.com, AZ - Jul 3, 2008
    Thanks to curcumin, the active ingredient in turmeric that has powerful anti-inflammatory and antioxidant components, the researchers say turmeric may treat ...
    Indian Gold
    MensHealth.com - July, 2008
    For decades, researchers have searched for an immunity superbooster that could hold back the tide of disease. In the spice markets of the Far East, they may have found it..."It's mind-boggling," says Dr. Aggarwal. "Turmeric is safe, and as far as the number of diseases it addresses, you name it. It truly has the potential of being a wonder spice." ...
    "95 percent turmeric extract" supplement at turmeric-curcumin.com
    Health.msn.com - July, 2008
    In the Western world, researchers have long suspected Curcuma longa to be more than just a sunburst-yellow spice that doubles as a home remedy. But only in recent years have they become sufficiently intrigued to look beyond folklore and subject turmeric to the rigors of 21st-century science."...
    Turmeric hope for diabetics
    Hindu, India - July 01, 2008
    Tortoriello claims that curcumin, an anti-inflammatory, anti-oxidant ingredient found in Turmeric (Curcuma longa) can significantly reduce insulin ...
    How to Prevent Colon Cancer (and Never Need a Colostomy)
    HealthNews, CA - Jun 26, 2008
    These include folic acid, curcumin, vitamin C, pomegranate juice, and fish oil. What do I tell my patients about these? "The evidence is just not in about ...
    Chemistry: An Everyday Approach to Chemical Investigation
    Business Wire (press release), CA - Jun 26, 2008
    Extraction of Curcumin from Turmeric. Experiment 10. pH-Titration. Experiment 11. Preparation & Acid-Base Properties of Ammonium Chloride. Experiment 12. ...
    US data reveals 24m diabetes sufferers
    NutraIngredients-usa.com, France - Jun 25, 2008
    ... linked to diabetes benefits in studies published over the past two months alone include pine bark extract, canola protein, cocoa flavanols and curcumin. ...
    India: Turmeric Prevents Type-2 Diabetes In Mice Experiment
    FreshPlaza, Netherlands - Jun 25, 2008
    The researchers believe that curcumin, the anti-inflammatory, anti-oxidant ingredient present in turmeric, diminishes insulin resistance and prevents Type 2 ...
    6 ways to spice up your diet
    Dallas Morning News, TX - Jun 24, 2008
    Curry powder: Turmeric, an ingredient in curry powder, contains curcumin. This phytochemical helps thwart cancer by switching off proteins that cause cells ...
    Feeling fat worse than actually being fat
    The Post, Pakistan - Jun 24, 2008
    They speculate that curcumin, the anti-inflammatory, anti-oxidant ingredient in turmeric, lessens insulin resistance and prevents Type 2 diabetes in these ...
    Can grandma's remedy help reduce diabetes, obesity?
    Sify, India - Jun 23, 2008
    They speculate that curcumin, the anti-inflammatory, anti-oxidant ingredient in turmeric, lessens insulin resistance and prevents Type 2 diabetes in these ...
    Health Highlights: June 23, 2008
    Forbes, NY - Jun 23, 2008
    The researchers believe curcumin -- an ingredient in turmeric -- may be responsible, United Press International reported. The study was presented at the ...
    Curry Spice Could Prevent Diabetes and Obesity
    Keep the Doctor Away, UK - Jun 23, 2008
    But the researchers say that stocking up on Turmeric makes you less susceptible to developing Type 2 diabetes – probably because of curcumin, ...
    The cancer - inflammation link
    Edmonton Sun,  Canada - Jun 23, 2008
    For example, many studies have shown that the anti-inflammatory activity of curcumin, found in the Indian spice turmeric, or even gingerol, found in ginger, ...
    What's the alternative?
    Times Online, UK - Jun 21, 2008
    The rates of Alzheimer’s are much lower among the elderly in India than in the West, and early studies show that curcumin, an antioxidant phytochemical ...
    Turmeric may help prevent diabetes, obesity
    DailyIndia.com, FL - Jun 20, 2008
    Researchers from Columbia University Medical Centre have found that curcumin, the anti-nflammatory, anti-oxidant ingredient in turmeric can significantly ...
    Dr. Sandy: Spicy Love
    NBC5.com, IL - Jun 19, 2008
    Tumeric is a main ingredient in curries and chemical; curcumin in turmeric gives the curry powder and gives it that bright yellow color. ...
    Counting on curcumin
    Livemint, India - Jun 16, 2008
    The researchers are trying to find out if curcumin works in fighting HPV. It will be available as a vaginal tablet or cream. The pilot project of a clinical ...
    Turmeric
    innovations report, Germany - Jun 11, 2008
    At the moment, he has named this creme "Microencapsulation of Curcumin and Turmeric Oil Extracted from Turmeric and Application in Cream Preparation". ...
    UK researchers exploring 'chemoprevention' to stall cancer
    Flesh and Stone, MN - Jun 10, 2008
    ... red wine, nuts and berries), curcumin (from turmeric–curry) and tricin (contained in wild rice) will present their findings Thursday, June 26th, ...
    fast food friendlies
    The Sun, UK - Jun 10, 2008
    The turmeric used in many Indian dishes contains super-nutrient curcumin which is packed with anti-oxidants and is said to lower the risk of bowel cancer. ...
    Cancer prevention: the natural way
    News-Medical.net, Australia - Jun 10, 2008
    ... products resveratrol (contained in grapes, red wine, nuts and berries), curcumin (contained in turmeric-curry) and tricin (contained in wild rice). ...
    Science is finding medical remedies in the spice cabinet
    The Plain Dealer - cleveland.com, OH - Jun 10, 2008
    Fifteen years after his first experiment, curcumin, the active ingredient in turmeric, is the subject of clinical trials in multiple myeloma, colon cancer, ...
    Breaking News from The Plain Dealer
    The Plain Dealer - cleveland.com, OH - Jun 10, 2008
    Its active ingredient is curcumin, used for centuries in traditional medicine to treat ailments from gallstones to anemia, to heal wounds and treat ...
    Researchers examine therapeutic benefits of turmeric
    Dallas Morning News, TX - Jun 10, 2008
    It seems that curcumin, the yellow pigment, has therapeutic potential for many maladies. That's what researchers at Baylor University Medical Center at ...
    Worldwide Epidemiological Cancer Studies Could Lead to Significant ...
    PR-USA.net (press release), Bulgaria - Jun 6, 2008
    The National Institute of Health has funded dozens of research studies over the past several years on curcumin and its positive effects on inflammation ...
    Today's health tip
    Ithaca Journal, NY - June 2, 2008
    New evidence suggests that its active ingredient, curcumin, might prevent or treat some diseases. The National Institutes of Health is recruiting patients ...
    SciDev.net
    SciDev.net, UK - May 29, 2008
    The yellow colouring agent in turmeric, curcumin, inhibits cancer cell proliferation by interfering with the activity of several key proteins involved in ...
    How to keep Alzheimer's at bay
    Times of India, India - May 28, 2008
    Ballard also emphasised the protective effects of curcumin which is found in turmeric, saying, "Studies show that curcumin may protect nerve cells and thus ...
    Healthy ways to spice up your life
    Trinidad News, Trinidad and Tobago - May 28, 2008
    This bright yellow curry spice gets its colour — and health benefits — from a compound called curcumin. Scientists believe curcumin may lessen muscle ...
    Turmeric may help in fighting psoriasis
    Indianapolis Star, United States - May 26, 2008
    Answer: There is growing interest in turmeric and its active ingredient, curcumin, for treating a variety of inflammatory conditions, including psoriasis. ...
    Turmeric offers lots of health benefits
    Food Consumer, IL - May 25, 2008
    By Sue Mueller Scientists have found curcumin, the active ingredient in the traditional herbal remedy and dietary spice turmeric, possesses a wide range of ...
    Indian Curry Powder: Fine Cuisine and Ayurvedic Medicine
    Natural News.com, AZ - May 23, 2008
    Turmeric (aka Curcumin) contains the antioxidant Curcuma, a yellow pigment. Turmeric is a natural pain killer that detoxifies the liver. ...
    Turmeric Found to Be Beneficial for Lung, Liver and Colon Health
    Natural News.com, AZ - May 22, 2008
    (NaturalNews) Turmeric, containing the active ingredient curcumin, is one of nature's most powerful healers. The medicinal properties of this spice have ...
    "A Future in which Breast Cancer Will Be Controlled"
    Newswise (press release) - May 21, 2008
    He has also discovered that phytochemicals from curcumin, derived from the turmeric plant, and piperine, from the fruit of the black pepper plant, ...
    Boomers are leading the charge to find foods that keep them vital ...
    OCRegister, CA - May 15, 2008
    Turmeric contains a compound called curcumin that may help keep the brain young. Older adults in Singapore who ate turmeric-rich curry often were half as ...
    Promising breast cancer results
    TheChronicleHerald.ca, Canada - May 15, 2008
    Turmeric, a spice widely used in Indian and South Asian cooking, contains a phytochemical called curcumin, which has been demonstrated to prevent tumour ...
    Heavy drinkers, smokers face Alzheimer's risk
    Times of India, India - May 10, 2008
    curcumin, an ingredient found in turmeric (haldi), reduces the tangling of brain cells and breaks up existing plaques in ...
    Food Compounds That Kill Test Tube Cancer Cells Analyzed
    Natural News.com, AZ - May 7, 2008
    Zunino's current studies build upon her 2006 findings about the ability of carnosol from rosemary; curcumin from turmeric; resveratrol from grapes; ...
    A Plan for Living a Long and Healthy Life
    Natural News.com, AZ - May 6, 2008 
    Turmeric (or curcumin) - This is one of the really important ones! A highly potent cancer fighter that recent tests have indicated protects cigarette ...
    Curcumin may helps fight diabetes
    Food Consumer, IL - May 1, 2008
    By David Liu, Ph. D. WEDNESDAY April 30, 2008 (Foodconsumer.org) -- Curcumin found in turmeric may help fight diabetes, according to a new study published ...
    Curcumin Reduces Heart Enlargement and May Prevent Heart Failure
    Natural News.com, AZ - Apr 7, 2008
    (NaturalNews) Eating curcumin, a natural ingredient in the spice turmeric, may dramatically reduce the chance of developing heart failure, researchers at ...
    Karmanos Researchers Find Non-Toxic Agents Added to Conventional ...
    Earthtimes, UK - Apr 13, 2008
    Anti-inflammatory properties and other health benefits have long been associated with curcumin and resveratrol. Curcumin, from the ginger family, ...
    Natural Remedies for Treating Arthritis
    Natural News.com, AZ - Apr 18, 2008
    Curcumin has been shown to be as effective as cortisone or phenylbutazone in certain models of inflammation. Curcumin also exhibits many beneficial effects ...
    Nutrition Considerations for Patients With Prostate Cancer, Part 2
    RedOrbit, TX - Apr 10, 2008
    Curcumin (480 mg, three times per day) - Curcumin has been shown to inhibit the growth of breast, colon and prostate cancer cells via several important ...
    Leading research in cancer prevention and food derivatives
    HULIQ (press release), NC - Apr 18, 2008
    Chemoprevention studies into diet-derived substances at Leicester began in 2000 with the study of the curry constituent curcumin. Since then, the research ...
    Plants That Protect Us
    Southwest News-Herald, IL - Apr 25, 2008
    The ARS scientists first reported in 2006 about the ability of carnosol from rosemary; curcumin from turmeric; resveratrol from grapes; and ellagic acid, ...
    Baby Boomers Redefining Food
    Sun-Sentinel.com, FL - Apr 24, 2008
    Double dose of spice: Turmeric contains a compound called curcumin that may help keep the brain young. Older adults in Singapore who ate turmeric-rich curry ...
    Diets are a-changin'
    The News-Press, FL - Apr 21, 2008
    Turmeric contains a compound called curcumin that may help keep the brain young. Cinnamon appears to have insulin-like properties that may help control ...
    Adequate Amounts of Omega-3 Oil May Help Prevent Heart Disease
    Natural News.com, AZ - Apr 21, 2008
    There are supplements available that protect against AGEs such as curcumin and quercetin. Also, many plant extracts fight AGEs such as ellagic acid, ...
    American Cancer Society awards research grants to 133 ...
    EurekAlert (press release), DC - Apr 14, 2008
    Shile Huang, PhD of Louisiana State University is studying a compound found in the curry spice tumeric called curcumin, which is now in early clinical ...
    The misery of arthritis
    Fortnightly Tenerife News, Spain - Apr 13, 2008
    Curry – turmeric contains a powerful ingredient, curcumin, which is thought to help both types of arthritis and seems to work by preventing a protein from ...
    Food Compounds That Kill Test-Tube Cancer Cells Analyzed
    Food Consumer, IL - Apr 12, 2008
    Zunino's current studies build upon her 2006 findings about the ability of carnosol from rosemary; curcumin from turmeric; resveratrol from grapes; ...
    LSUHSC researchers discuss investigation of natural cancer fighters
    Shreveport Times, LA - Apr 12, 2008
    Shile Huang, an assistant professor in the biochemistry department, talks how curcumin, a substance in turmeric, attacks cancer cells. ...
    Spice up your life and live longer too
    Sowetan, South Africa - Apr 3, 2008
    The main chemical in turmeric is curcumin, which is thought to slow the progression of certain neuro-degenerative diseases. Most recently, it has shown ...
    Protect Yourself from Harmful Toxins
    Stop Aging Now, DC - April 2, 2008
    Curcumin (turmeric) inhibits cancer-causing chemicals like benzopyrene (found in charcoal-broiled meat) and can neutralize toxic compounds from cigarette ...
    March is Colon Cancer Prevention Month
    Pacifica Tribune, CA - Mar 26, 2008
    According to researchers from Wake Forest University School of Medicine, Curcumin, from the spice turmeric, is now being used in human clinical trials for ...
    A Curry a Day Keeps The Doctor Away
    ShortNews.com, Germany - Mar 25, 2008
    The active ingredient curcumin was given to mice and will eventually be trialled on humans.Dr Maral Ouzounian says "it is still a leap to suggest using ...
    Find: New line of beneficial teas
    Dallas Morning News, TX - Mar 25, 2008
    Curcumin, turmeric's main active component, is a powerful antioxidant. Dr. Weil adds at least 100 percent of the daily value for vitamin C to each 8.2-ounce ...
    Shake On Oregano, Shake Off Disease?
    Sun-Sentinel.com, FL - Mar 20, 2008
    Curcumin, a component of turmeric, may assist the immune system in fighting the proteins that cause plaque in the brain of Alzheimer's patients. ...
    US: Turmeric protects skin during radiation treatment
    FreshPlaza, Netherlands - Mar 19, 2008
    In 2005, researchers from the University of Rochester Medical Center, in Rochester, NY, found that curcumin, the active ingredient in turmeric and the ...
    Boomers To Thank For Trends To Help Mind And Body
    Tampa Tribune, FL - Mar 18, 2008
    Double dose of spice: Turmeric contains a compound called curcumin that may help keep the brain young. Older adults in Singapore who ate turmeric-rich curry ...
    The Best Home Remedies May Be Sitting in Your Spice Cabinet
    AlterNet, CA - Mar 16, 2008
    Made from the powdered root of a tropical plant closely related to ginger, turmeric contains curcumin, a compound that is both a powerful anti-inflammatory ...
    Hot new research is helping curry fight cancer
    The West Australian, Australia - Mar 16, 2008
    Curcumin, which gives curry its yellow colouring and has been used in Eastern medicine for many years, is said to have powerful anti-cancer and ...
    Fighting Alzheimer’s
    Hindu, India - Mar 15, 2008
    Adding a lot of turmeric into curries cooked can help as curcumin present in turmeric has shown benefit in some studies. Supplementing B6, B12 and folic ...
    Arthritis and Joint Deterioration
    Black Hills Today, SD - Mar 14, 2008
    Turmeric contains curcumin and related compounds known as curcuminoids, which have good antioxidant properties. Manganese is required for enzymes involved ...
    Power foods
    Detroit Free Press, United States - Mar 14, 2008
    Double dose of spice: Turmeric contains a compound called curcumin that may help keep the brain young. Cinnamon appears to have insulin-like properties that ...
    Science Fair students tackle challenges
    Connecticut Post, CT - Mar 13, 2008
    ... explains her project, "Analysis of Spice Curcumin", to judge Mona Nolde, at the Connecticut Science Fair at Quinnipiac University in Hamden. ...
    Curry may cut cardiovascular risks
    The News-Press, FL - Mar 10, 2008
    By ROBERT PREIDT • HealthDay • March 11, 2008 Curcumin, an ingredient in the curry spice tumeric, can reduce heart enlargement and may lower the risk of ...
    Natural Ways to Prevent Alzheimer’s Disease
    Stop Aging Now, DC - Mar 10, 2008
    New research suggests that curcumin, found in turmeric, the main spice in curry, can stop the build-up of destructive beta-amyloid protein in the brain ...
    Food Compounds That Kill Test-Tube Cancer Cells Analyzed
    Science Daily (press release) - Mar 7, 2008
    Zunino's current studies build upon her 2006 findings about the ability of carnosol from rosemary; curcumin from turmeric; resveratrol from grapes; ...
    Curry is a heart-healthy
    SheKnows.com, AZ - Mar 6, 2008
    One of the newest heart-friendly compounds, curcumin, an ingredient in the curry spice turmeric, has been found to lower the risk of heart failure and ...
    It Was Then That I Curried You
    The Simon, CA - Mar 5, 2008
    It contains curcumin, which suppresses tumor growth. This is great news for a cancer-phobic spice enthusiast. This past weekend, I opened a little tub of ...
    Curcumin could be good for your heart
    Chicago Tribune, United States - Mar 4, 2008
    Curcumin, an ingredient in the curry spice turmeric, can reduce heart enlargement and might lower the risk of heart failure, say researchers at Toronto ...
    Spice of life?
    York Region Era Banner, Canada - Mar 3, 2008
    Researchers found when the ingredient, called curcumin, was given orally to mice with enlarged hearts, the compound served to prevent and reverse ...
    Revealed: The Best Testing Green Superfood Powder Products for ...
    Natural News.com, AZ - Feb 28, 2008
    ... chlorella cleanses the liver and blood, curcumin prevents cancer and arthritis, cherries ease inflammation, pomegranates prevent prostate cancer, ...
    Curry Spice May Thwart Heart Failure
    CBS News, NY - Feb 26, 2008
    (WebMD) Curcumin, an ingredient in the curry spice turmeric, may help prevent heart failure. That's according to two new studies done on rats, not people. ...
    Curcumin may cut heart failure risk says research duo
    NutraIngredients.com, France - Feb 25, 2008
    By Stephen Daniells 25-Feb-2008 - Curcumin, the natural pigment that gives the spice turmeric its yellow colour, may protect against heart failure - in mice ...
    Breast cancer: What you need to know (1)
    Food Consumer, IL - Feb 23, 2008
    Food packaging chemical bisphenol A linked to breast cancer Turmeric: Curcumin in turmeric, a yellow spice widely used in Indian cuisine, has long been ...
    Inflammation: What to Eat to Reduce Your Risk of Many Diseases
    Natural News.com, AZ - Feb 22, 2008
    Turmeric, and its yellowing substance curcumin, are most commonly found in Indian foods like curry and in mustards. The author makes capsules of grocery ...
    Ingredient In Yellow Curry Can Reduce Heart Enlargement And May ...
    Science Daily (press release) - Feb 22, 2008
    22, 2008) — Eating curcumin, a natural ingredient in the spice turmeric, may dramatically reduce the chance of developing heart failure, researchers at the ...

    The cat's out of the bag: Felines stave off heart disease
    Globe and Mail, Canada - Feb 22, 2008
    Now, modern science is providing convincing evidence that curcumin, a key ingredient in turmeric, does indeed have healing powers. ...

    Supplementing growth
    Express Pharma, India - Feb 21, 2008
    ... as a source of ‘essential’ selenium; Glucosamine for arthritic care and Curcumin from turmeric as an anti-oxidant in the US Pharmacopoeia," says Bammi. ...
    Turmeric ingredient could help with heart failure
    National Post, Canada - Feb 21, 2008
    Researchers at Toronto's University Health Network found that curcumin, the active ingredient in turmeric, both prevents and dramatically reverses ...
    Haldi, that wonder drug
    Deccan Herald, India - Feb 18, 2008
    Significantly, research work done in India has hinted at the anti-cancerous properties of curcumin, an active component of turmeric. Curcumin is also known ...
    25 Ways to Keep a Heart Healthy
    Best Syndication, CA - Feb 16, 2008
    Include anti-inflammatory herbs and spices such as curcumin and ginger. They work in the same way as anti-inflammatory drugs. 12. ...
    Study catches picture of deadly cancer enzyme
    Scientific American - Feb 13, 2008
    ... some natural products can affect cancer. Curcumin, the compound that makes the spice turmeric yellow, has been shown in studies to interfere with p300/CBP.
    Stressed Out? You're Not Alone
    Christian Broadcasting Network, VA - Feb 8, 2008
    This herb is also known as curcumin and is a powerful anti-inflammatory. Thus, it can help alleviate the damage that comes from stress. ...
    All about Alzheimer's disease
    PRESS TV, Iran - Feb 6, 2008
    Herbs such as Butcher's broom, Ginkgo biloba extract, Kava Kava, Curcumin, rosmarinic acid, the Chinese herb (qian ceng ta) and valerian root are effective ...
    Studies claim turmeric may lower cancer risk
    The News-Press, FL - Feb 5, 2008
    Animal studies are now being conducted using the ingredient curcumin, the active ingredient in turmeric. Curcumin only makes up about 3-5 percent by weight ...
    Book cuts through myths, misconceptions of the food we eat
    The Canadian Press - Feb 4, 2008
    "An Apple A Day" delves into the benefits of curcumin found in curry, the fact that the artificial sweetener aspartame won't cause cancer in humans and ...
    Indian Daal: Heart-healthy food
    Kalamazoo Gazette - MLive.com, MI - Feb 1, 2008
    Turmeric contains curcumin, which has been shown by researchers to help with heart health and acts as an anti-inflammatory. Packed with antioxidants ...
    Medifast Offers 5 Heart Healthy Tips in Recognition of Friday's ...
    Earthtimes, UK - Jan 31, 2008
    Anti-inflammatory herbs like curcumin and ginger have been shown to decrease the release of inflammatory molecules by inhibiting the COX-2 enzyme, ...
    A Lifesaving Legacy
    Newsweek - Jan 30, 2008
    These include substances like ellagic acid (berries), resveratrol (grapes), curcumin (turmeric), ECGC (green tea), procyanidin (cocoa) and genistein ...
    Hot stuff to boost your sex drive, heal your heart – curry can ...
    Fortnightly Tenerife News, Spain - Jan 18, 2008
    Indeed turmeric, used for centuries in India for making curries, has a main active ingredient called curcumin, which is being used in new clinical trials ...
    Alzheimer's Patients Describe Life with Disease
    NewsHour - Jan 17, 2008
    ... and we don't know exactly because there are studies that go both ways on this, but curcumin is one, folic acid, Coenzyme Q10 and omega fish oil. ...
    Turmeric promptly eases man's severe psoriasis
    Daily Press, VA - Jan 16, 2008
    Basic research suggests a number of reasons why curcumin, the active compound in turmeric, would have a beneficial effect in psoriasis (Biochemical ...
    Pain Management: It's Foods and Not a Drug
    Huffington Post, NY - Jan 14, 2008
    The reasons for adding them are included: The bright yellow pigment of this spice has the ingredient curcumin. Studies have shown that it has many ...
    Herbal Medicines For Dermatitis
    American Chronicle, CA - Jan 8, 2008
    Borage oil, Evening Primrose oil, Flax oil, B-complex, DMG (B15), B12, Calcium, Magnesium and Potassium (pH adjustment), Quercetin, Curcumin, Bromelain, ...
    The Alarming Increase In Double Mastectomies
    Newstarget.com, Taiwan - Jan 1, 2008
    It has also been found that by getting curcumin in your system, if you have cancer, this is just as or more effective in destroying cancer cells than ...
    Can the Red Wine Molecule Actually Add Twenty Years to the Life ...
    PR Web (press release), WA - Dec 31, 2007
    Some of the most promising candidates to date are curcumin (extract of Tumeric), Silymarin, Astralagus, especially Astragaloside IV, and a new class of ...
    Super ideas for your plate
    MiamiHerald.com, FL - Dec 25, 2007
    It contains curcumin, which has many reported health benefits including being an anti-inflammatory and a possible treatment for irritable bowel syndrome. ...
    PEOPLE'S PHARMACY
    Houston Chronicle, United States - Dec 16, 2007
    It may contain other natural compounds in addition to curcumin, the active ingredient in turmeric. More than 150 scientific articles have been published ...
    Latest findings on plant-derived cancer medicines
    Cancerfacts.com, WA - Dec 7, 2007
    "We have undertaken efficacy (effectiveness) studies on individual components of Blueberry Punch, such as curcumin, resveratrol and EGCG, ...
    Health Watch: Babies know who’s naughty or nice
    MetroWest Daily News, MA - Dec 1, 2007
    That's because turmeric, a spice used in curry, contains curcumin, a powerful anti-inflammatory that works similarly to Cox-2 inhibitors, drugs that reduce ...
    Coming soon to a supermarket near you
    Vancouver Sun,  Canada - Nov 21, 2007
    The new spice to watch for is curcumin, the compound that makes the Indian spice tumeric a dark yellow. Curcumin has recently been shown to reduce risk of ...
    The Latest News About Alzheimer’s
    Parade Magazine - Nov 21, 2007
    Then there is the fascinating observation that an ingredient present in curry, curcumin, may be beneficial. This may, in part, explain the relatively low ...
    Turmeric use
    Daily Press, VA - Nov 21, 2007
    A component of turmeric, curcumin, has anti-inflammatory as well as antioxidant activity and shows promise against psoriasis and other conditions (Annals of ...
    In your kitchen
    Independent, UK - Nov 20, 2007
    A single plant molecule can have a bewildering array of health-promoting effects – curcumin, for example, obtained from the spice turmeric, doesn't only ...
    Treatment For Toenail Fungus: Vinegar And Listerine
    Hartford Courant, United States - Nov 15, 2007
    Some research indicates that turmeric and its primary component curcumin can ease the inflammation of psoriasis and arthritis (Current Opinion in ...
    Curry in a healthy hurry
    Malaysia Star, Malaysia - Nov 10, 2007
    RECENTLY, turmeric (curcumin), a bright yellow coloured curry spice in Asian cooking has been grabbing the headlines for its ability to prevent many ...
    Turmeric back in the fight against cancer
    News-Medical.net, Australia - Nov 7, 2007
    Curcumin, the yellow component in turmeric that gives curry its flavour, is thought to have the ability to suppress tumours and people who eat a lot of ...
    Anti-Cancer Curry: Ingredient Might Help Battle Cancer
    National Ledger, AZ - Nov 7, 2007
    According to Tohoku University researcher Hiroyuki Shibata, MD, curcumin is one of the most widely studied plant-based chemicals with anti-cancer properties ...
    Anti-Cancer Curry? Ingredient May Help Fight Cancer
    Post Chronicle - Nov 7, 2007
    Curcumin, the yellowish component in turmeric that gives curry its flavor, can suppress tumors, according to some studies. It has even been suggested that ...
    Curry Offers Hope for Cancer and Alzheimer's Victims
    Inventorspot - Nov 6, 2007
    The main problem with curcumin is that its beneficial properties are severely reduced as the compound is digested. Japanese scientists at Tohoku ...
    Curry Could Treat Colorectal Cancer
    Associated Content, CO - Nov 5, 2007
    Curcumin, the yellowish component of turmeric has long been identified as an anti cancer agent, but has yet to be applied in any meaningful way to treat the ...
    Colorectal polyps less frequent in Indian-subcontinent Asians than ...
    Medicexchange, UK - Nov 5, 2007
    Other components of the diet are high in anti-oxidants -- such as turmeric which contains curcumin -- and may also protect against colorectal cancer. ...
    Turmeric healed her psoriasis
    Los Angeles Times, CA - Nov 5, 2007
    Curcumin, a component of turmeric, has anti-inflammatory as well as antioxidant activity and shows promise against psoriasis and other conditions. ...
    Spice as remedy tantalizes
    News & Observer, NC - Oct 31, 2007
    One of those substances is an antioxidant called curcumin. Curcumin is being studied for possible uses in the treatment of Alzheimer's and Parkinson's ...
    Nutrition tips to help prevent cancer
    MSNBC - Oct 31, 2007
    Recent studies show that Curcumin, the yellow spice found in Tumeric and Curry Powder, may have anti tumor compounds that can protect against breast cancer. ...
    High Blood Pressure Drugs May Prevent Alzheimer’s Disease Says Study
    SeniorJournal.com, TX - Nov, 2007
    October 5, 2006 – In a small test with senior citizens – age 65 to 84 – researchers found that curcumin — a chemical found in curry and turmeric — may help ...
    A spice
    separationsNOW.com (subscription), UK - Oct 14, 2007
    When its rhizomes are boiled for several hours and dried, they yield a deep orange-yellow substance known as turmeric or curcumin, which is used as a food ...
    Fight arthritis with these foods
    MSNBC - October 11, 2007
    Turmeric, sometimes called Curcumin, is a mustard-yellow spice from Asia. It is the main ingredient in yellow curry. Scientific studies have shown that ...
    Great global grazings
    Ottawa Citizen,  Canada - Oct 6, 2007
    "Turmeric's active ingredient is Curcumin," says Peacock. "It has many anti-inflammatory, antioxidant, antiviral and antibacterial properties, among others. ...
    Curcumin promotes blood vessel formation in normal cells
    Newindpress, India - Oct 4, 2007
    Curcumin, the naturally occurring compound in turmeric, is long known as a wonderful molecule with several proven medicinal effects, ...
    Spices prevent fatal diseases
    The Post, Pakistan - Oct 3, 2007
    Researchers have found that a substance known as Curcumin that is found in turmeric has anti-inflammatory properties. Turmeric can be used alone and is ...
    Spice up your health by adding turmeric to regular diet
    London Free Press, Canada - Sep 30, 2007
    Curcumin, the active molecule in turmeric, is one of the first molecules from foods for which major clinical trials in cancer treatment (not just in cancer ...
    Curry powder's Curcumin to kill and stops the growth of skin cancer
    TopCancerNews.com, TX - Sep 26, 2007
    Indian foods are, in many cases, spicy (and delicious), and that curry powder's Curcumin has been found to kill and stops the growth of melanoma skin cancer ...
    Add Color To Your Diet
    Tyler Morning Telegraph, TX - Sep 18, 2007
    Curcumin is a flavonoid in tumeric, the yellow spice in curry powder. It inhibits the growth of stomach cancers and other cancers. Genistein is a flavonoid ...
    Turmeric May Guard Against Childhood Leukemia
    PakTribune.com, Pakistan - Sep 10, 2007
    Our studies show that Turmeric and its coloring principle, Curcumin in the diet mitigate the effects of some of these risk factors," Nagabhushan said . ...
    Could Turmeric help to combat Alzheimer’s disease?
    Destination Santé, France - Sep 7, 2007
    Known as bisdemethoxy Curcumin, it appears to destroy the beta-amyloid plaques whose presence is a marker for the disease. In fact, this substance appears ...
    Eat rainbow colored foods
    Frost Illustrated, IN - Sep 4, 2007
    A pigment called Curcumin gives curry its distinctive yellow color and has been credited with cancer prevention. I would suggest that to stay healthy, ...
    Couple Research
    Tyler Morning Telegraph, TX - Sep 2, 2007
    She also studies the prostate cancer preventative effects of Curcumin (the yellow substance in curry spices). Dr. Srivastava investigates resveratrol, ...
    Emory Winship Cancer Institute Earns $12.5 Million Grant
    DentalPlans.com, FL - Aug 29, 2007
    Development of Novel Curcumin Analogs for the Treatment of Head and Neck Cancer: Curcumin is a principal ingredient in the Indian curry spice Tumeric. ...
    The skinny on spicy foods
    MSNBC - Aug 26, 2007
    The Curcumin that turns Turmeric yellow also helps reduce inflammation and aids muscle repair after heavy exercise, researchers at the University of South ...
    Turmeric moves from the kitchen shelf to the clinic
    INDOlink, CA - Aug 22, 2007
    By Francis C. Assisi 22 August 2007 - Indian-American researchers who have been studying Curcumin, the active ingredient of the ubiquitous Indian spice ...
    Common spice may help Alzheimer's patients
    Scientific American Magazine - August 17, 2007
    Further studies are needed to determine if increasing blood levels of macrophages using an oral Curcumin agent clear the amyloid plaques, ...
    Herbs and Herbal Supplements for Natural Gout Treatment
    American Chronicle, CA - Jul 9, 2007
    Curcumin, found in tumeric, which gives Tumeric’s bright colour, is regarded as a potent anti-inflammatory and pain relieving agent. ...
    Natural Herbs For Asthma Treatment
    American Chronicle, CA - Jul 8, 2007
    The active constituents are the diarylhepanoids, including Curcumin, which are found in the vividly yellow rhizome. In an uncontrolled trial in India, ...
    Cancer Pain Management
    Journal of American Medical Association (subscription), IL - Jul 3, 2007
    They discuss medications such as intravenous ketamine, intravenous lidocaine, and cannabis, and describe the use of herbs and supplements such as Curcumin ...
    6 ways to spice up your diet
    Dallas Morning News (subscription), TX - Jun 26, 2007
    Curry powder: Turmeric, an ingredient in curry powder, contains Curcumin. This phytochemical helps thwart cancer by switching off proteins that cause cells ...
    Adjust diet for pet with cancer
    Arizona Daily Star, AZ - Jun 26, 2007
    ... DMG (a nutrient found in grains and meat), garlic, Curcumin, and medicinal mushrooms are often prescribed. I'd use this regimen for about six months. ...
    Malaria drugs failed? Turn to Turmeric
    Newindpress (subscription), India - Jun 19, 2007
    Curcumin, a compound isolated from the Turmeric plant, has been found to possess qualities that can effectively fight malarial parasites, including the ...
    Forget fluoride - try Turmeric
    Auckland stuff.co.nz, New Zealand - Jun 12, 2007
    "This is due to its active ingredient, Curcumin, which has antioxidant and anti-inflammatory properties." Dr Pahuja contacted the Central Leader to promote ...
    Add Spices to Your Life
    Better Homes and Gardens - Jun 10, 2007
    This spice, which gives ballpark mustard its yellow color, contains Curcumin, a compound that's been researched for its potent anti-inflammatory activity. ...
    Healthy herbs and spices
    Lawrence Journal World, KS - Jun 6, 2007
    Its Curcumin may offer protection against cancer cells. • How to use it: Add it to rice, eggs or salad dressings. Try for about 1/8 teaspoon per day, ...
    DDW: To Prevent Colorectal Cancer, a Vegetarian Diet From Day One
    MedPage Today, NJ - May 21, 2007
    Two promising candidates are garlic and the Indian spice Curcumin, both of which have been shown to have a chemoprotective effect, he said.
    The Second Team
    USA Today - May 16, 2007
    Research on anti-cancer properties of Curcumin, a curry extract; Academic Decathlon president. Daniel Lage, Gulliver Preparatory School, Miami. ...
    New Research Sheds Light on Alzheimer's Disease
    abc7.com, CA - May 16, 2007
    Researchers say fish, spices like curry and Curcumin, and certain juices may reduce risk. And everyone agrees brain exercises like crossword puzzles and ...
    Four area students among competitors at international science fair
    Shreveport Times, LA - May 16, 2007
    Huang studied whether Curcumin, the active ingredient in curry, would slow or block the movement of breast cancer cells. She discovered that at a certain ...
    Scientists discover benefits of Turmeric in Indian dishes
    Hindustan Times, India - May 8, 2007
    It has been seen that Curcumin, the compound that gives Turmeric its yellow colour, stops leukaemia cells multiplying. He said: "Our studies show that ...
    ORAC and Antioxidants: Realizing the Potential
    Natural Products Industry Insider, AZ - May 4, 2007
    For comparison, he offered Curcumin, which has demonstrated its antioxidant and health benefits via in vitro, in vivo and clinical studies. ...
    HealthFirst-What Causes Alzheimer's
    ABC12.com, MI - May 1, 2007
    Researchers say fish, spices like curry and Curcumin, and certain juices may reduce the risk. You can see the ABC12 report by clicking on the video icon ...
    Spice up your health
    Kansas.com, KS - Apr 23, 2007
    Its Curcumin may offer protection against cancer cells. How to use it: Add it to rice, eggs or salad dressings. Try for about 1/8teaspoon per day, ...
    Curcumin, Also Known As Curry Powder, Has Anticancer Effects
    Medical News Today (press release) - Apr 22, 2007
    Curcumin, a Turmeric root extract, has been shown to possess activity in the treatment and prevention of cancer, multiple sclerosis, and Alzheimer's disease ...
    Curry Compound May Fight Rare Neurological Illness
    CBC News, - April 1, 2007
    FRIDAY, March 30 (HealthDay News) - A synthetic compound that's a distant chemical relative of a component of Curcumin - a spice used to make curry - shows ...
    Curcumin May Treat Prostate Cancer
    Ivanhoe, FL - Mar 21, 2007
    In the most recent issue of Cancer Research, researchers from the Comprehensive Cancer Center of the University of Alabama in Birmingham report Curcumin has ...
    Chemical relative of Curcumin may hold cure for neuromuscular disease
    DailyIndia.com, FL - Mar 21, 2007
    Boffins led by Chawnshang Chang, Ph.D. conducted a study on a mouse model and found that the chemical relative of Curcumin - the bright yellow spice found ...
    Cancer Researchers Add Spice To Research Against Rare ...
    Medical News Today (press release), UK - Mar 24, 2007
    Chang notes that ginger, a family of spices that includes Curcumin, is widely used in China as a folk medicine to treat male-pattern baldness. ...
    12 Myths about Colon Cancer
    eMaxHealth.com, NC - Mar 2, 2007
    In the area of prevention, researchers are looking at the effects of Curcumin (found in curry), resveratrol (found in red wine), ginger and the ...
    Medical Management of Patients With Head and Neck Cancer
    Medscape (subscription) - Mar 1, 2007
    Curcumin, commonly known as the spice Turmeric that is derived from the East Indian plant Curcuma longa, has been shown to have anticancer properties in ...
    The Natural Way to Ward Off Alzheimer's Disease
    Hornell Evening Tribune, NY - Feb 27, 2007
    Turmeric contains Curcumin which is used in Ayurvedic medicine for its antioxidant, anti-inflammatory, anti-carcinogenic, and other effects. ...
    Spice it Up: Turmeric
    FitSugar.com, CA - Mar 13, 2007
    Its active ingredient Curcumin, works in a very similar way to non-steroidal anti-inflammatory drugs. In fact the spice has been used in Ayurvedic ...
    Advance reported in fight against muscular dystrophy
    Taipei Times, Taiwan - Mar 6, 2007
    A newly developed Curcumin compound has proven effective against muscular dystrophy in tests on rodents conducted by a US-based research team led by a ...
    Health: Colorectal Cancer Study
    CBS 3, PA - Mar 27, 2007
    Hoping to avoid the same fate, Ned joined a study to test a pill made from an ingredient called Curcumin found in the spice Turmeric. ...
    Eating right helps give clear skin
    NorthJersey.com, NJ - Feb 28, 2007
    Preliminary research shows that Curcumin, the principle ingredient in Turmeric, can stop inflammatory processes in the body and prevent cell damage. ...
    From garlic to basil to curry, a healthy choice
    Salt Lake Tribune, UT - Feb 12, 2007
    Curcumin, commonly found in Turmeric - a yellow-orangish spice added to curry mixes - has anti-inflammatory properties. * Fight cancer: Eat more curry. ...
    Colon cancer polyps reduced by curry and onions
    TopCancerNews.com, TX - Feb 8, 2007
    Curcumin is the chemical found in Turmeric and is the key agent in the pill that the patients were administered. The amount of quercetin was similar to what ...
    Summer Holiday Health Essentials
    Response Source (press release), UK - Mar 26, 2007
    ... entering the tissues) and helps combat circulatory disorders including varicose veins, and Curcumin is a powerful anti-oxidant/anti-inflammatory agent. ...
    Fighting Colds with Spices
    6abc.com, PA - Feb 8, 2007
    In addition to its anti-inflammatory properties, research on Curcumin has also shown it to shrink pre-cancerous lesions known as colon polyps. ...
    Try turmeric for psoriasis, digestion
    Newsday, NY - Feb 6, 2007
    It contains a compound, curcumin, that has anti-inflammatory activity. Several readers have reported that taking turmeric capsules or putting turmeric on ...
    Spice up your health
    Regina Leader-Post, Canada - Feb 1, 2007
    Research has found curcumin (the source of the spice turmeric, which gives curry its characteristic bright yellow colour and strong taste), ...
    PEOPLE'S PHARMACY Fiber, fish oil may lower cholesterol
    Houston Chronicle, TX - Jan 28, 2007
    It contains a compound, curcumin, that has anti-inflammatory activity. Several readers have reported that taking turmeric capsules or putting turmeric on ...
    Turmeric wards off Alzheimer's, cancer
    NDTV.com, India - Jan 26, 2007
    Turmeric contains a powerful substance called curcumin, which shields the brain from the damage that leads to Alzheimer's. In 1989, Bharat Aggarwal, ...
    Help With Nail Fungus, Intestinal Gas, High Cholesterol
    Hartford Courant, CT - Jan 26, 2007
    A. Turmeric contains a compound, curcumin, that has anti-inflammatory activity. Several readers have reported that taking turmeric capsules or putting ...
    Simple steps to reduce the risk
    Toronto Star, Canada - Jan 25, 2007
    Spice it up: Turmeric, a spice common in East Indian cooking, contains curcumin, which may reduce inflammation in the brain, in turn cutting the risk for ...
    Pass on the salt in favor of healthier herbs
    Ann Arbor News, MI - Jan 24, 2007
    Turmeric's curcumin also has been shown to shrink precancerous lesions known as colon polyps. Zick says the amount needed to accomplish this is unclear, ...
    Turmeric for skin, digestion
    Los Angeles Times, CA - Jan 27, 2007
    It contains a compound, curcumin, that has anti-inflammatory activity. Several readers have reported that taking turmeric capsules or putting turmeric on ...
    Unlocking the secrets of curcumin
    Cochrane Times, Canada - Feb 7, 2007
    My constant perusal of the Lancet, New England Journal of Medicine and Women's Weekly Digest has convinced me to take three supplements; curcumin, ...
    Statins: the truth
    Daily Mail, UK - Jan 29, 2007
    Finally, try curcumin found in the spice turmeric. Curcumin has been found to reduce the stickiness of platelets in the blood and relax arteries.
    Spices of life
    Sun-Sentinel.com, FL - Jan 10, 2007
    Curcumin is the compound found in turmeric, a key ingredient in curry powder that provides its distinctive yellow hue. But curcumin adds much more than just ...
    Healthier eating can begin with spices
    Earthtimes.org - Jan 10, 2007
    In addition to its anti-inflammatory properties, research on curcumin has also shown it to shrink pre-cancerous lesions known as colon polyps. ...
    Curry - a spicy treatment for malaria
    Jamaica Gleaner, Jamaica - Jan 7, 2007
    Investigators are finding that curcumin has a wide range of powerful and useful properties. Here's the low-down on some of the most promising research to ...
    Spice up your food for a healthier diet
    Zee News, India - Jan 7, 2007
    In addition to its anti-inflammatory properties, research on curcumin has also shown it to shrink pre-cancerous lesions known as colon polyps. ...
    Olive oil may prevent cancer
    Business Standard, India - Jan 7, 2007
    Curcumin, an active ingredient in turmeric, garlic, ginger, fish oil and herbal products like amla, as well as those that belong to the phyllanthus group of ...
    Good Diet Includes Herbs
    MedIndia, India - Jan 7, 2007
    A substance known as curcumin found in turmeric has anti-inflammatory properties.Turmeric can be used alone or added to curry. Curcumin also shrinks ...
    Boost Your Health With Spices
    Food Consumer, IL - Jan 6, 2007
    Researchers have found that a substance known as curcumin that is found in turmeric has anti-inflammatory properties. Turmeric can be used alone, ...
    Study looks at intravenous gene therapy
    Science Daily (press release) - Nov 8, 2006
    ... During Radiation Therapy For Cancer (October 8, 2002) -- Cancer researchers at the University of Rochester Medical Center have found that curcumin, a substance ...
    Health Alert: Lifelong research
    WIS, SC - Nov 7, 2006
    ... commitment. Doctor Carmen Guerra hopes curcumin, a substance found in the Indian spice turmeric, can help prevent colon cancer. ...
    Medical advances don't happen overnight, but often over a lifetime
    49abcnews.com, KS - Nov 7, 2006
    Doctor Carmen Guerra hopes curcumin, a substance found in the Indian spice tumeric, can help prevent colon cancer. "Researchers ...
    Changing minds in Alzheimer's research
    Los Angeles Times, CA - Nov 5, 2006
    ... A number of promising experiments are underway, including the work of Greg Cole, a professor of medicine and neurology at UCLA, on the use of curcumin, a spice ...
    Analysis: Ancient medicine useful today
    United Press International - Nov 2, 2006
    ... condition. Today, turmeric dietary supplements are marketed as curcumin, the chemical that gives turmeric its yellow color. It's ...
    Curry may protect brain
    Orlando Sentinel, FL - Nov 1, 2006
    New research suggests that an ingredient found in curry - curcumin - might prevent the tangled clumps of protein found in the brains of Alzheimer's patients. ...
    Turmeric helps stave rheumatoid arthritis
    United Press International - Oct 31, 2006
    ... been used for centuries by practitioners of Ayurvedic medicine to treat inflammatory disorders, and the extract containing the ingredient curcumin is marketed ...
    Curry Good For Your Brain
    ABC News - Oct 26, 2006
    ... standard tests. Curcumin, found in the curry spice turmeric, possesses potent antioxidant and anti-inflammatory properties. It's ...
    Turmeric's cancer-fighter role gains support through studies
    Arizona Republic, AZ - Oct 9, 2006
    ... of breast cancer as well as prostate, lung and colon cancers, and recent research at the MD Anderson Cancer Center in Houston suggests that curcumin, an active ...
    Curcumin helps clear Alzheimer's plaques
    United Press International - Oct 4, 2006
    4 (UPI) -- Curcumin -- in curry and turmeric -- may help the immune system clear the brain of amyloid beta, the plaques found in Alzheimer's disease, says a US ...
    New Therapies
    WSOCtv.com, NC - Nov 11, 2006
    ... When comparing diets, one particular compound sparked Guerra's interest - curcumin, an ingredient found in the spice Tumeric, that's used to make curry and ...
    Supplements get spicy
    Wilkes Barre Times-Leader, PA - Nov 7, 2006
    ... Animal studies have found that curcumin, one of the active ingredients in turmeric, inhibits the growth of cancers. And curcumin ...
    The Health Benefits of Turmeric
    WTMJ-TV, WI - Nov 8, 2006
    You could move to India or just increase your intake of Curcumin. Curcumin is the natural pigment that gives the spice turmeric its yellow color. ...
    You can be too thin
    USA Weekend - Nov 3, 2006
    ... booster. The secret: curcumin, an antioxidant shown to improve memory in animals and reduce a brain toxin that's linked to Alzheimer's. ...
    Turmeric Prevents Experimental Rheumatoid Arthritis, Bone Loss ...
    Medical News Today (press release), UK - Nov 3, 2006
    ... Turmeric extract containing the ingredient curcumin is marketed widely in the Western world as a dietary supplement for the treatment and prevention of a ...
    Boost Memory and Protect Against Alzheimer's
    SeniorJournal.com, TX - Nov 2, 2006
    ... October 5, 2006 – In a small test with senior citizens – age 65 to 84 – researchers found that curcumin — a chemical found in curry and turmeric ...
    Lifelong Research
    CBS 5 - Green Bay, WI - Nov 1, 2006
    In Many Cases.. Advances In Science Require A Lifelong Commitment. Doctor Carmen Guerra Hopes Curcumin.. A Substance Found In The Indian Spice Tumeric.. ...
    UA study: Turmeric root stops arthritis
    Tucson Citizen, AZ - Nov 1, 2006
    ... The study by Dr. Janet L. Funk and Barbara N. Timmermann provides the first "in vivo" documentation of how extracts containing curcumin protect against ...
    Curry spice 'help for arthritis'
    Health Sentinel - Oct 31, 2006
    ... And it was this extract, containing curcumin, that was most effective at blocking the onset of rheumatoid arthritis in the rats. ...
    Curry spice 'help for arthritis'
    BBC News, UK - Oct 30, 2006
    ... And it was this extract, containing curcumin, that was most effective at blocking the onset of rheumatoid arthritis in the rats. ...
    Curry Ingredient Turmeric, Helps to Dampen Inflammatory Effects of ...
    Nutrition horizon (press release), Netherlands - Oct 30, 2006
    ... on rats. Turmeric, which gives curries their characteristic yellow-orange tinge, is a major dietary source of curcumin. Turmeric ...
    Curry may fight Alzheimer's
    Health24.com, South Africa - Oct 30, 2006
    Curcumin, a component of curry and turmeric, seems to help the immune system get rid of amyloid beta - the protein that builds up to form damaging plaques in ...
    Major research in cancer treatment
    Hindu, India - Oct 22, 2006
    ... "For the first time, we showed how curcumin derived from turmeric can act as an anti-HPV molecule and how it can be used for treatment of cervical cancer," Das ...
    Prevention's Anti-Aging Guide: How To Take Off 10 Years Or More ...
    The Ledger, FL - Oct 13, 2006
    ... Turmeric, the spice that makes curry yellow, is loaded with curcumin, a chemical with potent antioxidant and anti-inflammatory properties. ...
    Spice up disease-fighting ability
    Bradenton Herald,  United States - Oct 7, 2006
    ... Turmeric: Curcumin is the compound found in turmeric, a key ingredient in curry powder that provides its distinctive yellow hue. ...
    CURRIES FIGHT ALZHEIMER'S
    Mirror.co.uk, UK - Oct 5, 2006
    Scientists discovered that a chemical called curcumin, which is found in curry and turmeric, helped the body fight the illness. ...
    Chemical from Curry Helps Immune System's 'PacMen' Gobble Plaque ...
    SeniorJournal.com, TX - Oct 5, 2006
    October 5, 2006 – In a small test with senior citizens – age 65 to 84 – researchers found that curcumin — a chemical found in curry and turmeric ...
    Curcumin could cut plaque build-up linked to Alzheimer’s
    NutraIngredients-usa.com, France - Oct 4, 2006
    10/4/2006 - Curcumin, found extensively in curries, could boost the body’s ability to clear the build up of plaques in the brain that are linked to Alzheimer ...
    UCLA/VA Study Finds Chemical Found in Curry May Help Immune System ...
    UC Los Angeles, CA - October 3, 2006
    UCLA/VA researchers found that curcumin — a chemical found in curry and turmeric — may help the immune system clear the brain of amyloid beta, which form ...
    Chemicals in curry and onions may help prevent colon cancer
    Newstarget.com (press release), Taiwan - Sep 29, 2006
    ... form of precancerous polyps in the lower bowel known as familial adenomatous polyposis (FAP) were treated with regular doses of curcumin (the chemical found in ...
    Is your spice rack also a medicine chest?
    Philadelphia Inquirer, PA - Sep 28, 2006
    ... Turmeric.Curcumin is the compound found in turmeric, a key ingredient in curry powder that provides its distinctive yellow hue. ...
    Spice up disease-fighting ability; some seasonings carry loads of ...
    Cadillac News,  United States - Sep 22, 2006
    ... Turmeric: Curcumin is the compound found in turmeric, a key ingredient in curry powder that provides its distinctive yellow hue. ...
    Curcumin fights colorectal cancer
    Food Consumer, IL - Sep 22, 2006
    By Ben Wasserman. 24 Sept. (foodconsumer.org) - Curcumin may be used as a drug to curb the growth and spread of colorectal cancer because it reduces the ...
    Johns Hopkins' discoveries in a nutshell
    Joplin Independent, MO - Sep 22, 2006
    ... studies in populations that consume large amounts of curry, as well as laboratory research on rodents have strongly suggested that curcumin, a relatively ...
    Curcumin found to fight tumors
    Daily News - Galveston County, TX - Sep 20, 2006
    They’ve found that turmeric’s active ingredient, curcumin, works in the lab to fight skin, breast and other tumor cells. In ...

    August 2006 In addition to antiviral, wound-healing, anti-inflammatory, and antioxidant activity, there’s evidence that curcumin kills some types of cancer cells, inhibits oxidation of LDL (“bad”) cholesterol, and may block a chemical that’s involved in arthritis.

    August 2006 Curry and onion extracts could protect against colon cancer. Quercetin and curcumin, compounds found naturally in onions and curry, could reduce the risk of colon cancer, suggests a small clinical trial from the US. 

    August 2006 Treatment Based on Curry and Onions Reduced Precancerous Intestinal Growths. Although study participants received the two substances together, the researchers believe curcumin was the key ingredient. "The amount of quercetin we administered was similar to what many people consume daily. However, the amount of curcumin is many times what a person might ingest in a typical diet, since turmeric only contains on average 3% to 5% curcumin by weight," researcher Francis M. Giardiello, MD, of Johns Hopkins University School of Medicine, says in a news release.

    August 2006 Study Finds Compounds In Curry, Onion May Shrink Colon Polyps. The potential of curcumin to prevent and/or treat cancer in the lower intestines surfaced in studies in lab rats fed curry, as well as in observational studies of Asian populations that consume a lot of curry.

    August 2006 Pills containing curcumin, a substance found in turmeric (a key ingredient of curry), and quercetin, an anti-oxidant derived from onions, kept the adenomas at bay, according to Francis Giardiello, M.D., of Johns Hopkins here. Patients with familial adenomatous polyposis develop hundreds of adenomas and eventually colon cancer.

    July 2006 Curcumin, which gives curries their characteristic yellow tinge, is a potent killer of melanoma cells in vitro. Curcumin, found in the spice turmeric, has been shown in other studies to both inhibit cancer cell proliferation and encourage programmed cell death, or apoptosis, in various tumor cell lines, including multiple myeloma and squamous cell carcinomas.

    July 2006 "Tests in mice showed that curcumin, an active compound found in turmeric, helped stop the spread of breast cancer tumor cells to the lungs.

    June 2006 "treatment of cancer patients, curcumin has been used as capsules and if used in diabetic retinopathy, the dosage could be much lower."

    June 2006 "curcumin helps thwart cancer by "switching off" proteins that cause cells to multiply and by inducing cancer cells to self-destruct. The spice may also reduce risk of Alzheimer's, psoriasis and arthritis.

    June 2006 "curcumin, the active ingredient in turmeric. This Indian spice has been used for centuries to flavor curry. Recently, scientists have found that this antioxidant compound fights inflammation and discourages the buildup of amyloid plaques in the brain (Current Alzheimer's Research, April 2005). Such plaques are characteristic of Alzheimer's disease.

    May 2006 "Curcumin has also shown great promise in the prevention of cancer. It is the active ingredient in Tumeric, a type of curry spice. Research has been conducted for decades now, and it would appear that Curcumin has extremely powerful anti-inflammatory, anti-oxidant, and anti-tumor properties. It has also been shown to interfere with cell-signaling pathways, which works to suppress the transformation and proliferation of cancerous cells."

    April  2006 "Curcumin, the chemical ingredient found in turmeric – our ubiquitous “safran” – has been shown to have a double protective effect on the brain through its anti-oxidation property: it prevents deterioration of the communication among the cells of the brain (which is fundamental to the memory process) and it slows or actually prevents the formation of what are called amyloid plaques that are thought to be related to the genesis of Alzheimer’s disease."

    March 2006 "when colon-cancer cells were exposed to curcumin—the yellow pigment that gives curry its color—25 percent were destroyed within a day. "Studies have also shown that curcumin reduces the formation of blood vessels in cancerous cells and inhibits the cells' movement."

    February 2006 Curcumin is medically promising because inflammation and oxidative damage are contributors to so many diseases, such as Alzheimer's, Parkinson's, arthritis and various cancers, said Gregory Cole, a professor of medicine and neurology at the David Geffen School of Medicine at UCLA who has conducted numerous studies on the spice. Curcumin are being probed for their potential to prevent and treat a broad range of diseases: cancer, cystic fibrosis, Alzheimer's and arthritis. Researchers believe the Curcumin it contains fights disease partly by shutting down a powerful protein that promotes an abnormal inflammatory response in the body. The spice also has potent antioxidant properties (and may even lower cholesterol).

    January 2006 Curcumin protects against prostate cancer

    January 2006 Professor Bharat Aggarwal is a researcher at the MD Anderson Cancer Centre at the University of Texas in the United States, where a major focus of his work has been Curcumin, active component of the distinctive yellow curry spice turmeric. He said the dietary spices played an important role in fighting cancer.Masala a day keeps the doctor away.

    January 2006 (Consumer Reports) "Curcumin has shown promise for several conditions: Alzheimer's disease. Cancer. Cystic Fibrosis."

    November 2005 "Curcumin is a natural product isolated from the spice turmeric...shown to have antiangiogenic (anti-tumor) properties in vitro and in vivo".

    November 7, 2005 "Curcumin abolishes aberrant enzyme expression in brain tumor cells."

    November 2005 "Elevated MG levels in diabetes patients are believed to contribute to diabetic complications...Curcumin inhibited the MG-stimulated increase...Curcumin prevented the MG-induced apoptosis...Curcumin significantly reduced the MG-mediated impairment."

    October 25, 2005  "Low rates among Indians for colorectal, prostate and lung cancers as well as coronary heart disease and Alzheimer's first drew Western researchers to Curcumin. It's a hot topic in health journals, too, cited 967 times since 2000 in articles reported on PubMed, the National Library of Medicine's research service. It's a promising potential weapon against several cancers, Alzheimer's disease, cystic fibrosis, psoriasis and other diseases."

    October 16, 2005  "Curcumin the main ingredient of turmeric and the compound that gives curry its mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report researchers at The University of Texas M. D. Anderson Cancer Center."

    September 2005 "The DNA synthesis and the cellular growth were inhibited by Curcumin in dose-dependent manner in all the five malignant astrocytoma cell lines."

    August 2005 "(Curcumin) showed potent growth inhibitory activity (anti-tumor)."

    July 20, 2005 "Curcumin's promise is enormous as it appears to inhibit multiple pathways by which cancer grows, and we know it's nontoxic..."Curcumin affects virtually every tumor biomarker that we have tried"

    July 12, 2005 A study published in the upcoming issue of Cancer magazine shows Curcumin, a chemical pigment in turmeric, has promise fighting breast, colon, prostate and pancreatic cancers

    July 11, 2005 Curcumin, the yellow pigment found in the curry spice turmeric, inhibits melanoma cell growth and kills tumor cells, shows a new study

    June 9, 2005 The spice turmeric, which is often found in curry powder, contains a chemical that may help stop breast cancer from spreading. Researchers from the University of Texas M.D. Anderson Cancer Center

    May 5, 2005 Researchers at the Alzheimers Disease Research Center at UCLA are testing Curcumin's ability to treat the earlty stages of the disease. The Cystic Fibrosis Foundation is funding a clinical trial on Curcumin. Scientists at M.D. Anderson Cancer Center are studying Curcumin as a possible treatment for multiple myeloma and pancreatic cancer, based on research showing that it may stop cancer cells from proliferating and cause malignant tumors to self-destruct

    April 1, 2005 Curcumin under human trials for Alzheimer's prevention

    February 18, 2005: Alzheimer's disease involves amyloid {beta} (A{beta}) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment Curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation, cognitive deficits, and amyloid accumulation

    January 4, 2005: Curcumin, the yellow pigment in curry spice, is to be investigated for its potential in prevention of Alzheimer’s disease

    December 29, 2004: Curcumin, the yellow pigment in curry spice, inhibits the accumulation of destructive beta amyloids in the brains of Alzheimer's patients and also breaks up existing plaques.


    December 18, 2004:
    Turmeric prevents cancer, particularly leukemia, say researchers. Curcumin...may be responsible for much of this benefit


    December 10, 2004:
    Scientists believe that curcumin, a spice used in India and known for its anti-inflammatory effects, may prevent memory loss

    November 21, 2004: Curcumin), which has demonstrated anti-cancer properties in laboratory and animal studies of lung, colon and breast cancer conducted by Bharat Aggarwal, M.D., a professor in the department of Bioimmunotherapy Research

    April 22, 2004: Curry ingredient tested in cystic fibrosis fight...Daily Curcumin slashed the death rates of CF-stricken mice.

    April 19, 2004: Spice Protects Brain Cells, Could Prevent Alzheimer's Disease...Curcumin -- also known as cumin or curry -- is a natural spice that has high levels of phenols, potent antioxidants that can prevent cell damage caused by free radicals.

    April 04, 2004: Curry spice could alleviate cystic fibrosis...Curcumin, a component of turmeric, makes it possible for the protein to escape to the cell surface by starving the inspector proteins of calcium.

    December 1, 2003 (Healthcentral.com) - "Turmeric Eases Suffering From Psoriasis... researchers are looking into the potential health benefits of Curcumin, a key component of turmeric. One group found that Curcumin inhibits an enzyme called PhK associated with overactive cell growth in psoriasis"

    September 13, 2003 (Spizes.com) - "This research proves that Curcumin may prove to be a cheap, well-tolerated, and effective therapy for inflammatory bowel disease. This food ingredient has for generations been regarded as a potent anti-inflammatory within many eastern civilizations. It is equally intriguing that the same agent is a potent antineoplastic agent."

    September 9, 2003 (Healthcentral.com) - "Eating Turmeric on Cereal Helped Psoriasis Sufferer...
    Curcumin, the active ingredient, has anti-oxidant and anti-inflammatory properties. Researchers are studying this compound in conditions as diverse as Alzheimer's disease, arthritis and certain cancers."

    August 26, 3003 (Yahoo! News) - "Dietary constituents like Curcumin, a component of the spice turmeric (Curcuma longa); might have anti-inflammatory properties that can effectively treat delibitating illnesses like Crohn's disease (inflammatory bowel illness) or ulcerative colitis."

    June 8, 2003 (Charlotte Observer) - 
    "Q. Could you please respond to all of the articles that I've been reading lately that hail turmeric as a powerful herb for its anti-inflammatory abilities, cancer-prevention abilities and much more?
    A. Turmeric has been used as a spice in Indian cooking for centuries. It adds the yellow color and distinctive flavor to curry.
    Researchers have been studying an ingredient in turmeric called anti-inflammatory abilities, cancer-prevention abilities and much more?
    A. Turmeric has been used as a spice in Indian cooking for centuries. It adds the yellow color and distinctive flavor to curry.
    Researchers have been studying an ingredient in turmeric called Curcumin. This compound has antioxidant activity and also has strong anti-inflammatory properties."

    June 7, 2003 (New Zealand Health) - " This herb contains the yellow pigment curcumin. Curcumin tends to stay in the  gastrointestinal tract, where it seems to block the release of cell-damaging substances. It is linked to possible prevention of colon cancer, and in laboratory studies has been shown to slow the spread of prostate cancer cells."

    March 27, 2003 (Spizes.com) - "Curcumin could stop cancer cells with multiple myeloma from replicating and kill off the remaining cancerous cells."

    March 20, 2003 (Yahoo News) - "Curcumin, the substance that gives the spice turmeric its distinctive yellow colour, stopped the changes caused by excessive alcohol consumption that lead to liver damage. The research adds to the repertoire of benefits already shown by Curcumin, which include anti-oxidant properties and anti-cancer activity."

    March 13, 2003  (Reuters Health) - An ingredient in the curry spice turmeric may help suppress and destroy a blood cancer, early lab research shows--suggesting yet another health benefit from this long-heralded substance. Studies have also shown that Curcumin, even in large quantities, does not produce any known side effects in humans, the researcher noted. Based on this evidence, Aggarwal recommended that people with cancer should try to eat more Curcumin, if possible. "Whichever way you can take it, as much as possible,"

    February 2003 Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells

    February 12, 2003  (American Physiological Society) - Curcumin, the substance that gives turmeric its yellow color, and found in curry, has been found to consist of a natural anti-inflammatory compound. Scientists have already shown that it can suppress tumor blood vessel growth ...Curcumin inhibits alcohol-induced liver injury and lipid peroxidation inhibits alcohol-induced liver injury and lipid peroxidation...Not only did curcumin prevent alcohol-induced necroinflammatory changes, the yellow pigment from roots and pods of Curcuma longa stopped lipid peroxidation and the expression of the NF-KB-dependent genes.

    January 15, 2003 - "Now the humble Indian spice is being tested in differing fashions in two national laboratories — with stunning results — against cancer... Curcumin is a substance in curry long believed to have health benefits.The Ohio State University of Columbus has also posted exciting reports that turmeric has ‘‘demonstrated anti-cancer effects at all stages of tumor development in rodents and showed potential to kill cancer cells and prevent normal cells from being cancerous."

    November 20, 2002
    (USA Today Weekend) - "Curcumin helps stifle cancer. In test tubes, 80% of malignant prostate cells self-destructed when exposed to Curcumin. Feeding mice Curcumin dramatically slowed the growth of implanted human prostate cancer cells. It may do the same in breast and colon cancer cells, researchers say, speculating that Curcumin blocks the activation of genes that trigger cancer. Bonus: Curcumin's anti-inflammatory activity reduces arthritic swelling  and progressive brain damage in animals. In UCLA research, eating food laced with low doses of Curcumin slashed Alzheimer's-like plaque"

    October 8, 2002  (Reuters Health) - "A compound found in the curry spice turmeric may suppress production of a protein that spurs tumor growth in the body, researchers report...If the spice component does indeed reduce IL-8 activities as the findings suggest, "Curcumin is capable of working as a potent agent that reduces tumor promotion," the researchers conclude. The study, in a recent issue of the journal Cancer, is not the first to link Curcumin, a compound thought to be a potent anti-inflammatory agent, with certain health benefits. Curcumin, a compound thought to be a potent anti-inflammatory agent, with certain health benefits. Curcumin, a compound thought to be a potent anti-inflammatory agent, with certain health benefits. Studies also suggest that the compound might help heal wounds and fight Alzheimer's disease and multiple sclerosis."

    October 7, 2002 (University of Rochester Medical Center) - "Cancer researchers at the University of Rochester Medical Center have found that Curcumin, a substance in curry long believed to have health benefits, seems to protect skin during radiation therapy. Curcumin, the substance that gives turmeric its yellow color, is a natural anti-inflammatory compound and scientists have already shown that it can suppress tumor blood vessel growth. This process, called anti-angiogenesis, can strangle tumors."

    June 12, 2002 (Dr. Weil) - "Curcumin blocked the accumulation of beta-amaloid plaque and also appeared to reduce inflammation related to Alzheimer’s disease in neurologic tissue. ....Researchers at the University of Illinois have also found that it helps prevent plaque formation. And preliminary studies at Vanderbilt University suggest that Curcumin may block the progression of multiple sclerosis...Curcumin reduced plaque in the Alzheimer’s disease ...Turmeric appears to have significant Anti-inflammatory and cancer-protective effects as well"

    May 22, 2002 (Reuters Health) - "The curry spice Turmeric may help reduce and even prevent inflammation of the intestines...The spice contains Curcumin, a compound thought to be a potent anti-inflammatory agent"

    May 15, 2002 (Spizes.com) - "Turmeric can reduce radiotherapy-induced side-effects and radition burns" 

    April 24, 2002 (Reuters Health) - "Interest in the potential neuroprotective properties of Curcumin rose after studies found very low levels of neurological diseases such as Alzheimer's in elderly Indian populations. Added to this were studies confirming Curcumin as a potent anti-inflammatory agent, effective in wound healing"

    April 5, 2002  (Reuters Health) - "The substance that gives the spice Turmeric its yellow color may help fight cancer, preliminary evidence suggests.  Researchers have found that the active ingredient in Turmeric called Curcumin, can enhance the cancer-fighting ability "

    April 4, 2002 (Discovery Health Channel) - 
    "Preliminary studies in rats suggest that Curcumin, a compound found in the curry spice turmeric, may block the progression of multiple sclerosis (MS)...Interest in the potential neuroprotective properties of Curcumin rose after studies found very low levels of neurological diseases such as Alzheimer's in elderly Indian populations. Added to this were studies confirming Curcumin as a potent anti-inflammatory agent, effective in wound healing. And just last fall, researchers at the University of California, Los Angeles reported that Curcumin appeared to slow the progression of Alzheimer's in mice."

    "Therapeutic potential of Curcumin in human prostate cancer. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of  prostate cancer cells."

    "Results: Animals in which tumors had been initiated with DMBA and promoted with TPA experienced significantly fewer tumors and less tumor volume if they ingested either 0.2% or 1% Curcumin diets."

    "Results from a small 3-year study in patients with uveitis suggest that Curcumin (375 mg taken orally three times daily) worked as well as corticosteroid medications but without the side effects. In addition, the rates of recurrence as well as complications from uveitis were similar to the rates of patients taking corticosteroid medications. No patients complained of side effects from the Curcumin"

    "Diets rich in Curcumin, a compound found in the curry spice Turmeric, may help explain why rates of Alzheimer's disease are much lower among the elderly in India compared with their Western peers."

    "Curcumin acts as an anti-angiogenic agent, meaning it stops or prevents the production of blood vessels that feed tumors"

    "Numerous studies have found that Curcumin suppresses the proliferation of cancer cells and cholesterol/heart disease."

    "It has been known for thousands of years in Ayurvedic medicine that Turmeric extracts were beneficial for inflammatory conditions such as arthritis -- [and] since the '60s, there have been hundreds of publications on the mechanisms of Anti-inflammatory effects of Curcumin ...Curcumin has the additional benefit of reducing oxidative damage of the brain, which is several-fold elevated in Alzheimer's disease and likely contributes greatly to memory loss," says Frautschy.

    "Turmeric's protective effects on the cardiovascular system include lowering cholesterol and triglyceride levels, decreasing susceptibility of low density lipoprotein (LDL) to lipid peroxidation, (32) and inhibiting platelet aggregation. (33)"

    "Turmeric reduced the number of these plaques by a half. The researchers also found that Turmeric had other health benefits. It aids digestion, helps fight infection and guards against heart attacks."

    "Curcumin has been shown to exert even more impressive effects than aspirin in inhibiting colon cancer. In addition to inhibiting prostaglandin formation, Curcumin also exhibits potent antioxidant effects (in some experimental studies it was up to 300 times more potent than vitamin E)."

    "Curcumin could be a potentially therapeutic anti-cancer agent, as it significantly inhibits prostate cancer growth, as exemplified by LNCaP in vivo, and has the potential to prevent the progression of this cancer to its hormone refractory state"

    Curcumin, a compound found in turmeric (Curcuma longa), has a number of potential cancer-preventing mechanisms of action. The first is its inhibitory effect on the proinflammatory enzymes cyclooxygenase and lipoxygenase. A study found the anti-inflammatory efficacy of curcumin to be superior to indomethacin. Curcumin has also been found to induce G2/M phase cell cycle arrest in human colon cancer cells independently of its control of prostaglandin synthesis...Curcumin's tumor inhibiting effect is similar to many of the NSAIDs, including aspirin, ibuprofen, and indomethacin. A diet containing two-percent curcumin by weight reduced the percentage of animals developing colon cancers from 40 percent to zero."

    "Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of Curcumin. Curcumin inhibited the cell growth of HT-29 cells in a concentration- and time-dependent manner. Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1. These data suggest that a non-toxic concentration of Curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer."

    "The effects of 500 mg of Curcumin administered orally via capsules on serum peroxides and cholesterol levels were compared in 10 human volunteers before and after administration for 7 days. No adverse effects were reported. The data indicated significant decreases in serum lipid peroxides and in total cholesterol, (and) a significant increase in HDL(good) -cholesterol"

    "The Anti-carcinogenic effects of Turmeric and Curcumin are due in part to direct antioxidant and free-radical scavenging effect; but, they also enhance the body's natural antioxidant system, increasing glutathione levels, thereby aiding in hepatic detoxification of mutagens and carcinogens, and inhibiting nitrosamine formation."

    "Curcumin, a spice widely used in Indian dishes, has anti-carcinogenic and anti-inflammatory properties. It also inhibits the oestrogenic effects of DDT and is synergistic with phytooestrogens.A dietary modification with the introduction of soy products, Curcumin, cruciferous vegetables and low fat could be beneficial in reducing the risk of developing cancer and possibly the effects of DDT."

    "Curcumin...can retard the progress of dementia, according to a study conducted by an American expert... Curcumin is found to be far more effective, Prof Jeffrey Cummings of the University of California in Los Angeles (ULCA), who conducted the study, said."

    "Turmeric extracts were responsible for dramatic improvements in some patients with oral cancer and significantly reduced urinary excretion of tobacco mutagens in smokers. Also, the American Health Foundation, a prestigous mainstream biomedical research center in Valhalla, N.Y., has demonstrated inhibition of colon cancer and regression of colon tumors with Turmeric extracts."

    "Curcumin, a natural polyphenol and potent antioxidant, has shown chemopreventive activity in preclinical models. It has also been associated with regression of established malignancy"

    "Research suggests that Curcumin, the bright yellow flavonoid present in turmeric (Curcuma longa) roots, selectively inhibits... the blood to clot, [and] prevents excessive inflammatory response and reduces damage to vascular endothelia. Curcumin has also been shown to inhibit tobacco smoke mutagenicity, suggesting it may help Curcumin, the bright yellow flavonoid present in turmeric (Curcuma longa) roots, selectively inhibits... the blood to clot, [and] prevents excessive inflammatory response and reduces damage to vascular endothelia. Curcumin has also been shown to inhibit tobacco smoke mutagenicity, suggesting it may help protect the vascular endothelia from damage caused by smoking"

    "also aids digestion, particularly of protein, promotes absorption and regulates metabolism."

    "Curcumin is a powerful antioxidant and anti-inflammatory compoundfound in the curry spice Turmeric, which has a long history of dietary and medicinal use" 

    Curcumin 'may slow Alzheimer's'

    ALBERT EINSTEIN COLLEGE OF MEDICINE
    DEPARTMENT OF PATHOLOGY
    Brosnan CF. 2001
    Curcumin has been used for centuries to treat inflammatory disorders. Due to its low toxicity it is currently under consideration as a broad anti- inflammatory, anti- tumor cell agent. We conclude that gammadelta T cells (allergic inflammatory agents)...are highly sensitive to curcumin and that this effect may contribute to the anti- inflammatory properties of this compound. PMID*: 11544338, 8 Researches

    HOSPITAL OF THE NORTH SHORE- LONG ISLAND JEWISH HEALTH SYSTEM
    Trachtman H. 2003
    The protective effect of curcumin against (toxin)- induced injury…was not related to its antioxidant properties. Instead, curcumin enhanced expression of heat shock protein… PMID: 11322764- 3 Researchers
    DEPARTMENT OF ONCOLOGY, Augenlicht LH. 2003
    The butyrate response was compared in detail with…curcumin, a component of mustard and curry structurally and functionally related to sulindac that also has chemopreventive activitiy. PMID: 10969808- 3 Researchers

    AMERICAN HEALTH FOUNDATION
    CHEMOPREVENTION PROGRAM
    Reddy BS. 1999
    Curcumin inhibited colonic (tumor) formation (in an animal modeo) by 45%. PMID: 10223193- 4 Researchers

    AMERICAN HEALTH FOUNDATION
    DIVISION OF NUTRITIONAL CARCINOGENESIS
    Reddy BS. 1999
    Thus, chemopreventive activity of curcumin is observed when it is administered prior to, during, and after carcinogen treatment as well as when it is given only during the promotion/progression phase (starting late in premalignant stage) of colon carcinogenesis. PMID: 9973206- 7 Researchers

    AMERICAN HEALTH FOUNDATION
    DIVISION OF NUTRITIONAL CARCINOGENESIS
    Reddy BS. 1995
    The results indicate that dietary administration of curcumin significantly inhibited incidence of colon adenocarcinomas and the multiplicity of invasive, noninvasive, and total (invasive plus noninvasive) adenocarcinomas. Dietary curcumin also significantly suppressed the colon tumor volume by >57% compared to the control diet. Although the precise mechanism by which curcumin inhibits colon tumorigenesis remains to be elucidated, it is likely that the chmopreventive action, at leasat in part, may be related to the modulation of arachidonic acid metabolism (the pathway that also leads to inflammatory COX- 2). PMID: 7812955- 5 Researchers

    AMERICAN HEALTH FOUNDATION
    DIVISION OF NUTRITIONAL CARCINOGENESIS
    Reddy BS. 1993
    The results of the present study indicate that curcumin, present in turmeric, inhibits AOM- induced colonic preneoplastic lesions and other cellular events relevant to colon carcinogenesis. PMID: 8242846- 3 Researchers

    BAYLOR COLLEGE OF MEDICINE
    THE DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
    Tan TH. 1998
    Curcumin, a dietary pigment in curry, suppresses tumor initiation and tumor promotion.... Taken together, the inhibition of the MEKK1- JNK pathway reveals a possible mechanism of suppression of AP- 1 and NF- kappaB signaling (proteins overexpressed in pathological inflammation and cancer states) by curcumin, and may explain the potent anti- inflammatory and anti- carcinogenic effects of this chemical. PMID: 9674701- 2 Researchers

    CANCER RESEARCH CENTER OF HAWAII
    ETIOLOGY PROGRAM
    Cooney RV. 1999
    Heterocyclic aromatic amines (HAAs), a group of chemicals formed during high- temperature cooking of meat and fish, are potent mutagens and are suspected to play a role in colorectal (and just about every other form of) cancer.Lower levels of PhIP and MeIQx were observed in meat marinated with turmeric- garlic sauce. In contrast, marinating with barbecue sauce caused a 2.9- and 1.9- fold increase in PhIP and a 4- and 2.9- fold increase in MeIQx PMID: 10578481- 3 Researchers

    COLUMBIA UNIVERSITY
    COLLEGE OF PHYSICIANS AND SURGEONS
    Katz AE. 2001
    Curcumin causes a marked decrease in the extent of cell proliferation…and…could be a potentially therapeutic anti- cancer agent, as it significantly inhibits prostate cancer growth,…and has the potential to prevent the progression of prostate cancer to its hormone refractory state.
    PMID: 11398177- 5 Researchers

    COLUMBIA UNIVERSITY
    COLLEGE OF PHYSICIANS AND SURGEONS
    Katz AE. 2000
    These results, taken together with our previous results that curcumin can induce apoptosis in both androgen- dependent and androgen- independent prostate cancer cells, support our view that curcumin may be a novel modality by which one can interfere with the signal transduction pathways of the prostate cancer cell and prevent it from progressing to its hormone- refractory state.
    PMID: 10851300 - 3 Researchers

    CORNELL UNIVERSITY
    THE NEW YORK HOSPITAL- CORNELL MEDICAL CENTER
    Bertagnolli MM. 2000
    These data (approximately 63% decreased adenoma tumor formation) place the plant phenolics CAPE and curcumin among a growing list of anti- inflammatory agents that suppress Apc- associated intestinal carcinogenesis. PMID: 10783313- 8 Researchers

    CORNELL UNIVERSITY
    DR. MITCHELL GAYNORE, MEDICAL DIRECTOR. 2001
    Although there is abundant science to support the potential of nutritional therapies such as the natural COX- 2 inhibitors found in red wine and turmeric and the phytoestrogens, in soy for cancer prevention, few doctors are aware of this information.
    DEPARTMENT OF SURGERY, Bertagnolli MM. 2000
    These results show that mucosal…T cells and B cells increase in animals treated with curcumin, suggesting that curcumin modulates lymphocyte- mediated immune functions. PMID: 10729246- 4 Researchers

    CORNELL UNIVERSITY
    DEPARTMENT OF CARDIOTHORACIC SURGERY
    Dannenberg AJ. 1999
    We found that curcumin directly inhibited the activity of COX- 2. These data provide new insights into the anticancer properties of curcumin. PMID: 10190560- 5 Researchers

    CORNELL UNIVERSITY
    DEPARTMENT OF MEDICINE
    Rigas B. 1997
    Curcumin, the active ingredient of the rhizome of the plant turmeric (Curcuma longa Linn), a commonly used spice, prevents cancer in animal tumor models. The role of curcumin’s antiproliferative effect in human colon cancer remains to be established. PMID: 9422331- 4 Researchers

    CORNELL UNIVERSITY
    CORNELL CANCER RESEARCH LABORATORY
    Nitin T. Telang, 1994
    Curcumin, despite being an antioxidant, is also a non- steroidal anti- inflammatory agent. It is probable that curcumin may selectively kill clones of tumor cells, as has been reported. 1 Researcher

    CORNELL UNIVERSITY
    DEPARTMENT OF INTERNAL MEDICINE
    Awasthi YC. 1999
    Curcumin, an antioxidant present in the spice turmeric (Curcuma longa), has been shown to inhibit chemical carcinogenesis in animal models and has been shown to be an anti- inflammatory agent… These results suggest that GSTs play a major role in detoxification of lipid peroxidation products…and that these enzymes are modulated by curcumin. PMID: 10514034- 7 Researchers

    EMORY UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENT OF PHARMACOLOGY
    Pavlath GK. 1999
    Skeletal muscle is often the site of tissue injury due to trauma, disease, developmental defects or surgery. Yet, to date, no effective treatment is available to stimulate the repair of skeletal muscle…Systemic administration of the NF- kB inhibitor curcumin stimulates muscle regneration after traumatic injury. The striking effects of curcumin on myogenesis suggest therapeutic applications for treating muscle injuries. PMID: 10444409- 5 Researchers

    EMORY UNIVERSITY SCHOOL OF MEDICINE
    DIVISION OF CARDIOLOGY
    Medford RM. 1998
    (Curcumin was also found to inhibit TNF activated VCAM- 1, a pathway which can lead to pathological inflammation and is implicated in atherosclerosis). PMID: 9468519- 3 Researchers

    FLORIDA A&M UNIVERSITY
    COLLEGE OF PHARMACY AND PHARMACEUTICAL SCIENCES
    Mazzio EA. 1998
    Excessive nitric oxide (NO) production in the brain has been correlated with neurotoxicity and the pathogenesis of several neurodegenerative diseases. (Curcumin and other plant compounds were shown to significantly inhibit this potentially problematic imbalance). PMID: 9714085- 2 Researchers

    UCLA MEDICAL CENTER
    Shoskes DA. 2000
    The combination of mycophenolic acid with curcumin…reduces rental injury and facilitates repair. PMID: 10688038- 2 Researchers

    UCLA MEDICAL CENTER
    DEPARTMENT OF SURGERY, UCLA SCHOOL OF MEDICINE
    Shoskes DA. 1998
    curcumin reduce ischemia- reperfusion (blood flow obstructed) injury and its inflammatory sequelae. The bioflavonoids (curcumin) holds promise as agents that can reduce immune and nonimmune renal injury, the key risk factors in chronic graft loss. PMID: 9701255- 1 Researcher

    HARVARD MEDICAL SCHOOL
    Freeman MR. 1999
    [This group is looking at the relationship between curcumin, AP- 1 (a key player in the inflammatory cascade) and bladder muscle health]. PMID: 10444406- 7 Researchers

    HARVARD MEDICAL SCHOOL
    DEPARTMENT OF DERMATOLOGY
    Byers HR 1998
    These results indicate that curcumin has direct antiangiogenic activity in vitro and in vivo. The activity of curcumin in inhibiting carcinogenesis in diverse organs such as the skin and colon may be mediated in part through angiogenesis inhibition. PMID: 10780880- 8 Researchers

    HENRY FORD HOSPITAL
    DEPARTMENT OF MEDICINE
    Chapman RA. 1998
    We have investigated the antiproliferative effect of curcumin, an antitumor agent with antioxidant and anti- inflammatory properties...These findings have implications for developing curcumin- based anticancer and anti- inflammation therapies. PMID: 9719490- 5 Researchers

    HENRY FORD HOSPITAL
    DIVISION OF HEMATOLOGY/ONCOLOGY
    Gautam SC. 1997- 98
    (Curcumin was also found to inhibit aspects of the NF- Kappa B cascade, a pathway which can lead to pathological inflammation and cancer proliferation). PMID: 9439980- 5 Researchers.

    HENRY FORD HOSPITAL
    DEPARTMENT OF INTERNAL MEDICINE
    Gautam SC. 1997- 98
    (This group of scientists from Henry Ford Hospital are investigating curcumins role as an anti- inflammatory in this most complex biochemical pathway). PMID: 9168063- 6 Researchers

    MANHATTAN EYE, EAR AND THROAT HOSPITAL
    DEPARTMENT OF OTOLARYNGOLOGY
    Schantz SP. 1998
    (Curcumin and other agents were found to inhibit two cell lines of head and neck squamous cell carcinomas). PMID: 9482545- 5 Researchers

    MEDICAL COLLEGE OF OHIO
    DEPARTMENTS OF UROLOGY AND PATHOLOGY

    Selman SH. 2002
    The development of an effective nontoxic agent that may be used immediately after bladder tumor resection to prevent the implantation of tumor cells would be a significant clinical advancement…curcumin is a potent cytotoxic agent against (multiple) bladder tumor cell lines. Curcumin effectively inhibits tumor implantation and growth in this murine bladder tumor model. PMID: 11547120- 5 Researchers

    MEMORIAL SLOAN- KETTERING CANCER CENTER
    DEPARTMENT OF SURGERY, HEAD AND NECK SURGERY

    Sacks PG. 1998
    Combinations allowed for a dose reduction of 4.4- 8.5- fold for EGCG and 2.2- 2.8- fold for curcumim. EGCG and curcumin were noted to inhibit neoplastic growth by different mechanisms, a factor which may account for their demonstrable interactive synergistic effect. PMID: 9525275 – 5 Researchers

    MEMORIAL SLOAN- KETTERING CANCER CENTER
    SCHANTZ S. 1997
    Effective chemoprevention of aerodigestive tumors could have far- reaching effects. Aerodigestive cancer accounts for one- third of all cancer deaths in the United States and is the most common cancer in some areas of the world...Novel agents are under development (especially for heavy smokers): epigallacatchin gallate, or green tea, curcumin, and a new emphasis on folic acid. PMID: 9433643- 2 Researchers

    MERCY CANCER INSTITUTE
    CANCER RESEARCH LIBRARY
    Zaren HA 1998
    Results of the present study suggest that curcumin may inhibit BaP- induced forestomach cancer in mice by affecting both activation as well as inactivation pathways of BaP metabolism in the liver...Therefore, it seems reasonable to postulate that curcumin may exert anticarcinogenic activity either by inhibiting activation of BaP or (and) by enhancing the detoxification of (+)- anti- BaPDE (the metabolite of BaP that is highly carcinogenic). PMID: 9744529- 7 Researchers

    MICHIGAN STATE UNIVERSITY
    DEPARTMENT OF HORTICULTURE AND NATIONAL SAFETY AND TOXICOLOGY CENTER

    Nair MG. 2000
    (Curcuminoids) from Cucuma longa were assayed for their cytotoxicity, antioxidant and anti- inflammatory activities. These compounds showed activity against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines. Curcumins I- III also showed good inhibition of the COX- II enzyme…PMID: 10969724- 3 Researchers

    MICHIGAN STATE UNIVERSITY
    DEPARTMENT OF HORTICULTURE AND NATIONAL SAFETY AND TOXICOLOGY CENTER

    Nair MG. 1998
    …three curcuminoids displayed topoisomerase I and II enzyme inhibition activity (an imbalance or excess in topoisomerase enzyme activity, the enzyme responsible for breaking and repairing DNA, is believed at the root of many cancer processes). PMID: 9584408- 3 Researchers

    NATIONAL CANCER INSTITUTE
    DIVISION OF CANCER PREVENTION

    Sigman CC. 2000
    Numerous diet- derived agents are included among the >40 promising agents and agent combinations that are being evaluated clinically as chemopreventive agents for major cancer targets including breast, prostate, colon and lung. Examples include green and black tea…curcumin…PMID: 10721931- 13 Researchers

    NATIONAL CANCER INSTITUTE
    LABORATORY OF CELLULAR AND MOLECULAR BIOLOGY
    Boone CW. 1998
    (Researchers concluded curcumin and green/black tea extracts prevented radiation induced DNA damage). PMID: 9858893- 7 Researchers

    NATIONAL CANCER INSTITUTE
    DIVISION OF BASIC SCIENCES
    Pommier Y. 1997
    (The NCI has been investigating curcumin for specific activities against HIV). PMID: 9301668- 7 Researchers

    NATIONAL CANCER INSTITUTE
    DIVISION OF CANCER PREVENTION AND CONTROL (DCPC)
    ,
    Sigman CC. 1996
    (Curcumin is one of a number of plant compounds that are under investigation by the Division of Cancer Prevention and Control (DCPC) of the National Cancer Institute as a “promising chemopreventive agent.” PMID: 9154168- 25 Researchers

    NATIONAL CANCER INSTITUTE
    LABORATORY OF MOLECULAR PHARMACOLOGY
    Pommier Y. 1995
    The present data suggest that HIV- 1 integrase inhibition may contribute to the antiviral activity of curcumin. These observations suggest new strategies for antiviral drug development that could be based upon curcumin as a lead compound for the development of inhibitors of HIV- 1 integrase. PMID: 7748198- 5 Researchers

    NATIONAL CANCER INSTITUTE
    CELLULAR DEFENSE AND CARCINOGENESIS SECTION
    Yeh GC 1998
    These results suggest that the chemopreventive effect of curcumin may be due, in part, to its ability to compete with aryl hydrocarbons for both the AhR and CYP1A1 (part of an essential detoxification enzyme system).... The chemopreventive effect of curcumin has been variously ascribed to the antioxidant properties of curcumin, inhibition of cyclooxygenase activity, suppression of activator protein- 1- mediated transcription, and induction of apoptosis of tumor cells. Based on our results, curcumin also appears to decrease carcinogen activation. PMID: 9698073- 4 Researchers

    NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
    EXPERIMENTAL THERAPEUTIC BRANCH
    George S. Roth. 1999
    Thus, our results suggest that DA triggers a death program via oxidative stress- mediated activation of nuclear transcription factors AP- 1 and NF- kB. These apoptotic molecular events may explain the DA- related neurodegenerative processes. 5 Researchers

    NATIONAL INSTITUTE ON AGING
    MOLECULAR PHYSIOLOGY AND GENETICS SECTION, GERONTOLOGY RESEARCH CENTER
    Roth GS. 1999
    (Utilizing curcumin studying inflammation factors AP- 1 and NF- kappa B to help determine the mechanisms at play in normal cell metabolism). PMID: 10419543- 5 Researchers

    NEW YORK MEDICAL COLLEGE
    GRADUATE SCHOOL OF HEALTH SCIENCES
    Duvvi, 2001.
    Curcumin, a spice widely used in Indian dishes, has anti- carcinogenic and anti- inflammatory properties. It also inhibits the oestrogenic effects of DDT and is synergistic with phytoestrogens. PMID: 11467202- 1 Researcher

    NORTH CAROLINA STATE UNIVERSITY
    AGRICULTURAL RESEARCH SERVICE, U.S. DEPARTMENT OF AGRICULTURE, AND NORTH CAROLINA AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF FOOD SCIENCE
    Fleming HP. 2003
    Turmeric was found to almost completely prevent aldehyde formation. PMID: 11052754- 3 Researchers

    NORTHWESTERN UNIVERSITY
    DEPARTMENT OF PATHOLOGY
    M. S.V. Bhide. 1992
    This study shows that curcumins inhibit cancer at initiation, promotion and progression stages of development...The results of our anticarcinogenicity studies with curcumins are strengthened by the recent epidemiological finding that dietary intake of turmeric may provide protection against pulmonary cancer among cigarette smokers...Curcumins inhibit the initiation step of carcinogenesis by changing the activity of phase I and phase II carcinogen metabolizing enzymes, thus altering the nature and lowering or removing potent proximate carcinogens that can reach critical intracellular targets. 2 Researchers

    PENNSYLVANIA STATE UNIVERSITY COLLEGE OF MEDICINE
    DEPARTMENT OF MEDICINE

    Kumar R. 1995
    These findings demonstrate that curcumin is a potent inhibitor of a growth stimulatory pathway,…and may potentially be useful in developing anti- proliferative strategies to control tumor cell growth. PMID: 7634398- 4 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF CHEMICAL BIOLOGY
    Conney AH. 1997
    (Curcumin was observed to have a strong inhibitory effect on multiple models of tumor formation in animals). PMID: 9054592- 8 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF CHEMICAL BIOLOGY
    Conney AH. 1997
    Combinations of curcumin and RA (vitamin like compound) have a particularly potent inhibitory effect on the proliferation of HL- 60(human leukemia ) calls. PMID: 9112257- 5 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF CHEMICAL BIOLOGY
    Frenkel K. 1997
    (Topical curcumin demonstrated significant antitumor effects against mutiple animal models. Significant activities wer eobserved with all curcuminoids). PMID: 9591190- 3 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY

    Conney AH. 1995
    (Rutger’s researchers investigated different curcuminoids for their anti- tumor effects and found that I and II were most active). PMID: 7586157- 8 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF BIOLOGICAL SCIENCES
    Huang HI. 1995
    (In chronic inflammation, signals induce the production of nitric oxide (NO.) that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite. Curcumin and compounds from rosemary and tea inhibit this compound). PMID: 7553604- 3 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF BIOLOGICAL SCIENCES
    Chan MM. 1995
    Curcumin, contained in the rhizome of the plant Curcuma longa Linn, is a naturally occurring phytochemical that has been used widely in India and Indonesia for the treatment of inflammation. ...(Curcumin was also found to inhibit activation of NF- Kappa B, a pathway which can lead to pathological inflammation and cancer proliferation).  There was more than a thousand- fold difference between the efficacy of curcumin (5uM) and that of NAC (60mM). PMID: 7786295- 1 Researcher 

    RUTGERS UNIVERSITY
    DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
    Conney AH. 1994
    These results indicated that not only did curcumin inhibit the number of tumors (colon, forestomach and duodenum) per mouse and the percentage of mice with tumors but it also reduced tumor size. PMID: 7954412- 6 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
    Conney AH. 1992
    (Topical application of benzo(A)pyrene (B(a)P), a most potentially carcinogenic compound in smoke, was significantly inhibited by application of curcumin). PMID: 1423891- 5 Researchers

    RUTGERS UNIVERSITY
    DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
    Conney AH. 1992
    This result suggests that dietary curcumin may inhibit AOM (powerful carcinogen)- induced colonic neoplasia in mice. PMID: 1611594- 6 Researchers

    STANFORD UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENTS OF SURGERY AND GENETICS
    Michael R. Freeman
    Previous studies have demonstrated that curcumin (diferuloylmethane), a potent inhibitor of tumor promotion, inhibits AP- 1- mediated transcription. 7 Researchers

    TUFTS UNIVERSITY SCHOOL OF MEDICINE
    Fini ME. 2002
    Our findings provide evidence that curcuminoids target the FGF- 2 angiogenic signaling pathway [FGF- 2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis)] and inhibit expression of gelatinase B [an essential component in the process of tumour invations and metastasis]in the angiogenic process. PMID: 10744729- 8 Researchers

    TUFTS UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENTS OF OPHTHALMOLOGY AND ANATOMY AND CELLULAR BIOLOGY
    M. Elizabeth Fini. 1999
    Curcuminoids, natural products of the Indian spice turmeric, are potent antioxidant and anti- inflammatory agents that have been entered into Phase I clinical trials for chemo- preventation by the National Cancer Institute. At least part of their biological activity can be attributed to their capacity to inhibit activation of AP- 1 and NF- kB transcription factors...To our knowledge, this is the first study showing the efficacy of curcuminoids as implantable drugs for inhibition of angiogenesis locally or as orally active drugs to inhibit angiogenesis systemically...Our findings provide evidence that curcuminoids target the FGF- 2 angiogenic signaling pathway and inhibit expression of gelatinase B in the angiogenic process. 8 Researchers

    TUFTS UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENT OF FAMILY MEDICINE AND COMMUNITY HEALTH
    Line PS. 1998
    These data suggest that combinations of natural plant compounds (curcumin and isoflavones) may have preventive and therapeutic applications against the growth of breast tumors induced by environmental estrogens. PMID: 9831541- 3 Researchers

    TUFTS UNIVERSITY SCHOOL OF MEDICINE
    DIVISION OF NUTRITIONAL CARCINOGENESIS
    Reddy BS. 1997
    (Curcumin and other agents may plan an important inhibitory role in the promotion/progression stage of colon carcinogenesis). PMID: 9102217- 5 Researchers

    TUFTS UNIVERSITY SCHOOL OF MEDICINE
    UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES
    Maheshwari RK. 1999
    These results show that curcumin enhanced would repair in diabetic impaired healing, and could be developed as a pharmacological agent in such clinical settings. PMID: 10564565- 8 Researchers

    TUFTS UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENT OF PATHOLOGY, BETHESDA
    Maheshwari RK. 1998
    It may be possible that transforming growth factor- beta1 plays an important role in the enhancement of wound healing by curcumin. PMID: 9776860- 7 Researchers

    TUFTS UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENT OF PATHOLOGY
    Maheshwari RK. 1996
    Since curcumin inhibited the proliferation of HUVEC (a model for testing abnormal cell proliferation), it could turn out to be a very useful compound for the development of novel anti- cancer therapy. PMID: 8913274- 4 Researchers

    UNIVERSITY OF ARIZONA
    COLLEGE OF PHARMACY

    Schneider CD. 2000
    (The University of Arizona has received a multi- million dollar U.S. government grant to study turmeric’s anti- inflammatory activities. PMID: 10911509- 2 Researchers

    UNIVERSITY OF CALIFORNIA
    DEPARTMENTS OF MEDICINE AND NEUROLOGY

    Cole GM 2001
    Inflammation in Alzheimer’s disease (AD) patients is characterized by increased cytokines and activated microglia... Low and high doses of curcumin significantly lowered oxidized proteins and interleukin- 1beta, a proinflammatory cytokine elevated in the brains of these mice. With low- dose but not high- dose curcumin treatment, the astrocytic marker GFAP was reduced, and insoluble beta- amyloid (Abeta), soluble Abeta, and plaque burden were significantly decreased by 43- 50%. In view of its efficacy and apparent low toxicity, this Indian spice component shows promise for the prevention of Alzheimer’s disease. PMID: 11606625

    UNIVERSITY OF CALIFORNIA SAN DIEGO
    DIVISION OF GASTROENTEROLOGY, DEPARTMENT OF MEDICINE
    Chauhan DP 2001
    These data suggest that a non- toxic concentration of curcumin has a significant effect on the in vitro growth of HT- 29 cells, specifically inhibits COX- 2 expression, and may have value as a safe chemopreventive agent for colon cancer. PMID: 11566484- 3 Researchers

    UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE
    CHILDREN’S HOSPITAL RESEARCH FOUNDATION

    Stanberry LR. 1999
    (Curcumin “provided significant protection” in an animal model against herpes simplex virus type 2). PMID: 10443534- 4 Researchers

    UNIVERSITY OF FLORIDA
    ARGARWAL A. MEDICINE

    Nick HS, 2001
    HO- 1 occurs as an adaptive and protective response to several inflammatory stimuli…Curcumin has anti- inflammatory antioxidant and renoprotective effects. PMID: 11500326 – 4 Researchers

    UNIVERSITY OF IDAHO
    DEPARTMENT OF FOOD SCIENCE AND TOXICOLOGY
    Hendrix K. 1997
    (This group of scientists from the University of Idaho is studying curcumin’s effects on animal immune functions.) PMID: 9049662- 3 Researchers

    UNIVERSITY OF ILLINOIS
    DEPARTMENT OF FOOD SCIENCE AND HUMAN NUTRITION
    Fisher C. 1996
    Therefore, curcumin when administered i.p. can act as an effective chemopreventative agent towards DMBA- induced rat mammary tumorigenesis and mammary adduct formation. PMID: 8635149- 4 Researchers

    UNIVERSITY OF ILLINOIS AT CHICAGO
    THE PROGRAM FOR COLLABORATIVE RESEARCH IN PHARMACEUTICAL
    SCIENCE AND THE DEPARTMENT OF MEDICINAL CHEMISTRY AND PHARMACOGNOSY, COLLEGE OF PHARMACY

    Kim JY 2001
    …a novel curcuminoid isolate from turmeric that has been demonstrated to protect neuronal cells from beta- amyloid insult… PMID: 11549465 – 2 Researchers

    UNIVERSITY OF ILLINOIS AT CHICAGO
    THE PROGRAM FOR COLLABORATIVE RESEARCH IN PHARMACEUTICAL
    SCIENCE AND THE DEPARTMENT OF MEDICINAL CHEMISTRY AND PHARMACOGNOSY, COLLEGE OF PHARMACY
    KIM JK 2001
    beta- Amyloids (betaA) induced oxidative stress is a well- established pathway of neauronal cell death in Alzheimer’s disease. From turmeric, Curcuma longa L. (Zingiberaceae), three curcuminoids where found to protect cells from betaA insult…These compounds were better antioxidants than alpha- tocopherol. alpha- Tocopherol did not protect the cells from betaA insult…PMID: 11297823 – 3 Researchers
    PZZUTO JM. 1999 (Curcumin and other chemopreventives inhibit skin carcinogenesis in an animal model) PMID: 10615860- 2 Researchers

    UNIVERSITY OF KENTUCKY
    DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
    Chen C. 1999
    Curcumin is a potent inhibitor of Epstein- Barr virus cell lines. This effect appears to be mediated through enhanced apoptosis. A further investigation of this effect may be useful in prevention and therapy of B- cell lymphoma in immunodeficient patients. PMID: 10527697- 6 Researchers

    UNIVERSITY OF KENTUCKY
    DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
    BONDADA S. 1999
    It has been well known that curcumin is a powerful inhibitor of proliferation of several tumor cells.…NF- kappaB (critical factor in the pathology of inflammation and cancer) binding activity was also downregulated almost completely by curcumin…curcumin caused the growth arrest and apoptosis of lymphoma (cell lines)…PMID: 10527691- 5 Researchers

    UNIVERSITY OF KENTUCKY
    DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
    NAGABHUSHAN M. 1998
    Curcumin (Cur) is a phenolic component of common spice, turmeric. We have reported earlier that it possesses antineoplastic and immunosuppressive properties in vitro. PMID: 9733605- 6 Researchers

    UNIVERSITY OF KENTUCKY
    DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
    NAGABHUSKAHN M. 1998
    An extract of a common spice (turmeric) is an effective inhibitor of this (an Epstein- Barr virus (EBV) related) process. PMID: 9457037- 5 Researchers

    UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
    DEPARTMENT OF RADIATION ONCOLOGY

    You W. 1999
    Curcumin has anti- inflammatory, antiproliferative, and antitumor effects. The results suggest that apoptosis (cellular suicide) is involved in the curcumin- induced inhibition of tumor cell growth, and genes associated with cell proliferation and apoptosis may be playing a role in the chemopreventive action of curcumin.…[curcuma longa i.}…is getting the attention of cancer investigators because of its chemopreventive properties against human malignancies. PMID: 1044542- 2 Researchers

    UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
    DEPARTMENT OF SURGERY
    Salahudeen AK. 1998
    These findings provide evidence that turmeric and curcumin provide protection against oxidative stress in a renal cell line. PMID: 9436613- 4 Researchers

    UNIVERSITY OF MISSOURI- KANSAS CITY
    HORMONE RESEARCH LABORATORY, SCHOOL OF DENTISTRY AND MEDICINE
    Virji AS. 2000
    It is concluded that curcumin is considerably more potent than genistein and quercetin, but cisplatin is five fold more potent than curcumin in inhibition of growth and DNA synthesis…The data presented in this study demonstrate that curcumin compares favorably with cisplatin in its inhibitory effect on both cell growth and DNA synthesis in human oral squamous carcinoma cell line PMID: 10928101- 2 Researchers

    UNIVERSITY OF NORTH CAROLINA
    DEPARTMENT OF MEDICINE, CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
    Sarto RB. 1999
    We conclude that curcumin potently inhibits cytokine- mediated NF- kappa B activation (this group has identified a mechanism that this critical factor in cancer and inflammation pathologies is inhibited). PMID: 10477620

    UNIVERSITY OF NORTH CAROLINA
    DEPARTMENT OF MEDICINE, CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
    R. BALFOUR SARTO, 1999.
    Nontraditional or alternative medicine is becoming an increasingly attractive approach for the treatment of various inflammatory disorders among patients unresponsive to or unwilling to take standard medications....The use of natural anti- inflammatory products provides an attractive and safe alternative to modulate inflammatory disorders. Curcumin is an anti- inflammatory food product that has been used for centuries in Asian cultures. However, the lack of information regarding a mechanism of action for curcumin combined with unknown effects on mucosal inflammatory gene expression have precluded the widespread clinical use of curcumin in western cultures for treatment of intestinal inflammatory disorders. Our data clearly indicate that cytokine- mediated expression of the adhesion molecule ICAM- 1 and the chemokine IL- 8 in IEC’s is blocked by curcumin treatment...Together, these data provide strong evidence that curcumin blocks IEC gene expression by inhibiting the signal leading to IKK activation, subsequent I- ?Bá phosphorylation/degradation, and NF- ?B activation. This study provides a strong rational to investigate the effect of curcumin in an in vivo experimental model of intestinal inflammation. 7 Researchers

    UNIVERSITY OF PITTSBURGH
    DEPARTMENT OF PATHOLOGY
    Zarnegar R. 2002
    (Confirmed that curcumin is an inhibitor of Ap- 1, a protein which can play a pathophysiological role in the proliferation of cancer cells and inflammation). PMID: 10713700- 3 Researchers

    UNIVERSITY OF TEXAS
    DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY
    Ansari GA 2000
    Curcumin (diferuloylmethane), a yellow pigment of turmeric with antioxidant properties has been shown to be a cancer preventative in animal studies conducting glutathione research. PMID: 10996298- 8 Researchers

    UNIVERSITY OF TEXAS HEALTH CENTER AT TYLER
    DEPARTMENT OF MOLECULAR BIOLOGY
    Rao LV. 2000
    We investigated the effect of curcumin, a natural plant phenolic compound known to exhibit anticarcinogenic, antioxidant, and anti- inflammatory properties, on Egr- 1 expression (regulates a number of pathophysiologically relevant genes)…the data show that curcumin suppresses the induction of transcription factor Egr- 1. PMID: 10674404- 2 Researchers

    UNIVERSITY OF TEXAS HEALTH CENTER AT TYLER
    DEPARTMENT OF MEDICAL SPECIALTIES
    Rao LV. 2000
    Overall, the data suggest that the anticarcinogenic and anti- inflmmatory properties of curcumin may be related to its ability to inhibit cellular gene expression regulated by transcription factors NF- kappa B, AP- 1, and Egr- 1. PMID: 9437186- 3 Researchers

    UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
    DEPARTMENT OF MOLECULAR ONCOLOGY
    Aggarwal BB. 1998
    Our results demonstrate that the anti- inflammatory properties of curcumin may be attributable, in part, to inhibition of leukocyte (white blood cell) recruitment. (Curcumin was also found to inhibit TNF activated NF- Kappa B, a pathway which can lead to pathological inflammation and cancer proliferation). Curcumin should be explored for its therapeutic value in atherogenesis, bacterial sepsis, inflammation, and tumor metastasis. PMID: 9586949- 4 Researchers

    UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
    DEPARTMENT OF BIOIMMUNOTHERAPY
    Aggarwal BB. 1997
    Pharacologically safe compounds that can inhibit the proliferation of tumor cells have potential as anticancer agents. Curcumin, a diferuloylmethane, is a major active component of the food flavor turmeric (Curcuma longa) that exhibits anticarcinogenic properties in vivo... Overall our results suggest that curcumin is a potent antiproliferative agent for breast tumor cells and may have potential as an anticancer agent. PMID: 9215611- 4 Researchers

    UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
    DEPARTMENT OF MOLECULAR ONCOLOGY
    Aggarwal BB. 1995
    (Curcumin was also found to inhibit a pathway leading to NF- Kappa B, a cascade which can lead to pathological inflammation and cancer proliferation). PMID: 7559628- 2 Researchers

    BHARAT B. AGGARWAL, 1995.
    In the present report we demonstrate that curcumin (diferuloylmethane), a known anti- inflammatory and anticarcinogenic agent, is a potent inhibitor of NF- kB activation. 2 Researchers

    UNIVERSITY OF TEXAS MEDICAL BRANCH
    DEPARTMENT OF HUMAN BIOLOGICAL CHEMISTRY AND GENETICS,
    Awashi YC. 2003
    …kept on a diet supplemented with only 0.005% (w/w) curcumin had significantly less opacification of lenses… PMID: 10814889 – 6 Researchers

    UNIVERSITY OF TEXAS MEDICAL BRANCH
    DEPARTMENT OF INTERNAL MEDICINE
    Awashi YC. 1999
    Curcumin, an antioxidant present in the spice turmeric (Curcuma longa) , has been shown to inhibit chemical carinogenesis in animal models and has been shown to be an anti- inflammatory agent. Taken together, these results suggest that GSTs (specific detoxification enzymes) play a major role in detoxification of lipid peroxidation products…and that these enzymes are (positively) modulated by curcumin. PMID: 10514034- 7 Researchers

    UNIVERSITY OF TEXAS MEDICAL BRANCH
    DEPARTMENT OF HUMAN BIOLOGICAL CHEMISTRY AND GENETICS
    Perez- Polo Jr. 1999
    (Curcumin is being studied for its positive influence on AP- 1, a protein which can play a pathophysiological role in the proliferation of cancer cells and inflammation). PMID: 10555784- 3 Researchers

    UNIVERSITY OF TEXAS MEDICAL BRANCH
    DEPARTMENT OF INTERNAL MEDICINE, GALVESTON,
    Awasthi S. 1998
    Our results suggest that induction of enzymes involved in the detoxification of the electrophilic products of lipid peroxidation may contribute to the anti- inflammatory and anti- cancer activities of curcumin. PMID: 9675878- 6 Researchers

    UNIVERSITY OF TEXAS MEDICAL BRANCH
    AWASHI YC.
    Curcumin treatment caused a significant induction of the glutathione S- transferase (GST) isozyme (detoxification enzyme)…and these studies suggest that curcumin may be an effective protective agent against cataractogenesis (formation of cataracts) induced by lipid peroxidation (oxidation of fat). PMID: 8901798- 6 Researchers

    UNIVERSITY OF TOLEDO
    COLLEGE OF ART & SCIENCES
    Jankun J. 2001
    Understanding how curcumin inhibits lipoxygenase may help in the development of novel anti- cancer drugs used for treatment where lipoxygenases are involved. PMID: 11029517- 4 Researchers

    WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENT OF MEDICINE
    Majumdar AP. 2001
    Curcumin appears to exert its anticarcinogenic properties by inhibiting proliferation and inducing apoptosis in certain gastric and colon cancer cells. PMID: 11396178- 3 Researchers

    YALE UNIVERSITY SCHOOL OF MEDICINE
    DEPARTMENT OF PHARMACOLOGY

    Sartorelli AC. 1997
    Curcumin, a potent inhibitor of tumor promotion and of tumor cell growth, has also been shown to have antioxidant properties and to inhibit NF- kappa B (NF- Kappa B is a pathway which can lead to pathological inflammation and abnormal cancer proliferation)...Curcumin caused a marked reduction in NF- kappa B activity in nuclear extracts of HL- 60 cells (human leukemia cell line) exposed to this agent… PMID: 9112258- 3 Researchers

    Anto, R. J., T. T. Maliekal, et al. (2000). L-929 cells harboring ectopically expressed relA resist curcumin-induced apoptosis. Journal of Biological Chemistry. [print] May 275(21): 15601-15604. {a} Division of Cancer Biology, Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, KER, 695014, India

    Began, G., M. Goto, et al. (2000). Response surfaces of total oil yield of turmeric (Curcuma longa) in supercritical carbon dioxide. Food Research International. [print] 33(5): 341-345. {a} Department of Applied Chemistry and Biochemistry, Kumamoto University, Kumamoto, 860-8555, Japan

    Chatterjee, S., P. S. Variyar, et al. (2000). Effect of gamma-irradiation on the volatile oil constituents of turmeric (Curcuma longa). Food Research International 33(2): 103-106. {a} Food Technology Division, Bhabha Atomic Research Centre, Mumbai, 400085, India

    Dixit, D. and N. K. Srivastava (2000). Distribution of photosynthetically fixed 14CO2 into curcumin and essential oil in relation to primary metabolites in developing turmeric (Curcuma longa) leaves. Plant Science Shannon. March 152(2): 165-171. {a} Department of Plant physiology, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow, 226015, India

    Gopalan, B., M. Goto, et al. (2000). Supercritical carbon dioxide extraction of turmeric (Curcuma longa). Journal of Agricultural and Food Chemistry. [print] June 48(6): 2189-2192. {a} Department of Applied Chemistry and Biochemistry, Kumamoto University, Kumamoto, 860-8555, Japan

    Hazra, P., A. Roy, et al. (2000). Growth characters as rhizome yield components of turmeric (Curcuma longa L.). Crop Research Hisar. March 19(2): 235-240. {a} Bidhan Chandra Krishi Viswavidyalaya, Pundibari, North Bengal Campus, Cooch Behar, WB, 736 165, India

    Masuda, T., H. Bando, et al. (2000). A novel radical terminated compound produced in the antioxidation process of curcumin against oxidation of a fatty acid ester. Tetrahedron Letters. March 41(13): 2157-2160. {a} Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima, 770-8502, Japan

    Park, E. J., C. H. Jeon, et al. (2000). Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. Journal of Pharmacy and Pharmacology. [print] April 52(4): 437-440. {a} College of Pharmacy, Wonkwang University, Iksan, Cheonbuk, 570-749, South Korea

    Punithavathi, D., N. Venkatesan, et al. (2000). Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. British Journal of Pharmacology. [print] September 131(2): 169-172. {a} Meakins-Christie Laboratories, McGill University, 3626 St. Urbain Street, Montreal, QC, H2X 2P2, Canada

    Ramirez, B. A., A. Soler, et al. (2000). An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen. Mechanisms of Ageing and Development. [print] April 114(3): 207-210. {a} A.S.A.C Pharmaceutical International, A.I.E. Alicante, C/Sagitario, 14, 03006, Alicante, Spain

    Ramirez, B. A., A. Soler, et al. (2000). An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio: Implications for atherogenesis prevention. Mechanisms of Ageing and Development. [print] October 119(1-2): 41-47. {a} A.S.A.C. Pharmaceutical International A.I.E., C/ Sagitario 14, 03006, Alicante, Spain

    Ramsewak, R. S., D. L. DeWitt, et al. (2000). Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine Jena. [print] July 7(4): 303-308. {a} Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI, 48824, USA

    Rasmussen, H. B., S. B. Christensen, et al. (2000). A simple and efficient separation of the Curcumins, the Antiprotozoal constituents of Curcuma longa. Planta Medica. [print] May 66(4): 396-398. {a} Dept. of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, 2100, Copenhagen, Denmark

    Scartezzini, P. and E. Speroni (2000). Review on some plants of Indian traditional medicine with antioxidant activity. Journal of Ethnopharmacology. [print] July 71(1-2): 23-43. {a} Department of Pharmacology, University of Bologna, Via Irnerio, 48, 40126, Bologna, Italy

    Sharma, M., R. K. Mandial, et al. (2000). Therapeutic efficacy of Mastilep in treating subclinical mastitis of variable etiology in lactating cows. Indian Veterinary Journal. [print] March 77(3): 261-263. {a} Department of Veterinary Microbiology, College of Veterinary and Animal Sciences, Himachal Pardesh Krishi Vishvavidyalaya, Palampur, 176 062, India

    Singh, A. K., A. Singh, et al. (2000). Evaluation of turmeric (Curcuma longa L.) germplasm under low hills condition of Himachal Pradesh. Crop Research Hisar. [print] September 20(2): 324-326. {a} HPKV Regional Research Station, Dhaulakuan, HP, 173 001, India

    Singh, J. P., U. K. Prasad, et al. (2000). Effect of irrigation and drainage requirement on water-use efficiency and yield of pure and maize (Zea mays) - based intercrops. Indian Journal of Agricultural Sciences. Feb. 70(2): 65-68. {a} Department of Agronomy, Rajendra Agricultural University, Pusa, BR, 848 125, India

    Singh, R. and B. Rai (2000). Antifungal potential of some higher plants against Fusarium udum causing wilt disease of Cajanus cajan. Microbios . [print] 102(403): 165-173. {a} Soil Microbiology and Ecopathology Laboratory, Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi, 221 005, India

    Skrzypczak, J. E., N. P. McCabe, et al. (2000). Curcumin inhibits lipoxygenase by binding to its central cavity: Theoretical and X-ray evidence. International Journal of Molecular Medicine. [print] November 6(5): 521-526. {a} Urology Research Center, Department of Urology, Medical College of Ohio, 3000 Arlington Avenue, Toledo, OH, 43699-0008, USA

    Ushida, J., S. Sugie, et al. (2000). Chemopreventive effect of curcumin on N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. Japanese Journal of Cancer Research. [print] September 91(9): 893-898. {a} Oto-Rhino-Laryngology, 1st Department of Pathology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500-8705, Japan

    Agarwal, S. S. and V. K. Singh (1999). Immunomodulators: A review of studies on Indian medicinal plants and synthetic peptides Part I: Medicinal plants. PINSA B. June Aug 65(2-3): 179-204. {a} Sanjay Gandhi Post-Graduate Institute of Medical Science, Lucknow, 226 014, India

    Antony, S., R. Kuttan, et al. (1999). Immunomodulatory activity of Curcumin. Immunological Investigations. Sept. Dec. 28(5-6): 291-303. {a} Amala Cancer Research Centre, Thrissur, KER, 680 553, India

    Ashraf, M. Z., M. S. Y. Khan, et al. (1999). Endothelium modulated vasorelaxant response of a polypharmaceutical herbal drug (lipotab) and its individual constituents. Journal of Ethnopharmacology. July 66(1): 97-102. {a} Department of Physiology, VP Chest Institute, University of Delhi, Delhi, 110007, India

    Began, G., E. Sudharshan, et al. (1999). Interaction of curcumin with phosphatidylcholine: A spectrofluorometric study. Journal of Agricultural and Food Chemistry. Dec. 47(12): 4992-4997. {a} Department of Food Engineering and Department of Protein Chemistry and Technology, Central Food Technological Research Institute, Mysore, 570 013, India

    Bhaumik, S., R. Anjum, et al. (1999). Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Letters. Aug. 456(2): 311-314. {a} Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India

    Chander, H., A. Nagender, et al. (1999). Laboratory evaluation of plant extracts as repellents to the rust red flour beetle, Tribolium castaneum (Herbst), on jute fabric. International Pest Control 41(1): 18-20. Cent. Food Technol. Res. Inst. Reg. Cent., GN Eng. Coll. PO, Gill Road, Ludhiana-141 006, India

    Chatterjee, S., D. S. R. Padwal, et al. (1999). Effect of gamma-irradiation on the antioxidant activity of turmeric (Curcuma longa L.) extracts. Food Research International 32(7): 487-490. {a} Food Technology Division, Bhabha Atomic Research Centre, Mumbai, 400085, India

    Chauhan, S. K., B. P. Singh, et al. (1999). Estimation of curcuminoids in Curcuma longa by HLPC and spectrophotometric methods. Indian Journal of Pharmaceutical Sciences 61(1): 58-60. {a} R and D Laboratory, Indian Herbs, Saharanpur, India

    Choudhary, D., D. Chandra, et al. (1999). Modulation of radio response of glyoxalase system by curcumin. Journal of Ethnopharmacology 64(1): 1-7. {a} Sch. Life Sci., Jawaharlal Nehru Univ., New Delhi-110067, India

    Chun, K. S., Y. Sohn, et al. (1999). Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin. Mutation Research. July 428(1-2): 49-57. {a} College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-gu, Seoul, 151-742, South Korea

    Das, A. B., S. Rai, et al. (1999). Karyotype analysis and cytophotometric estimation of nuclear DNA content in some members of the Zingiberaceae. Cytobios 97(384): 23-33. {a} Cytogenetics Laboratory, Regional Plant Resource Centre, Bhubaneswar, OR, 751015, India

    Das, S. and C. B. Kumar (1999). Antifungal effect of five plant extracts on the variants of Trichophyton rubrum. Biocontrol Science. Sept. 4(2): 83-86. {a} H/74, 2nd phase, Chhend, Rourkela, OR, 769015, India

    Deters, M., C. Siegers, et al. (1999). Choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat. Planta Medica. Oct. 65(7): 610-613. {a} Institute of Experimental and Clinical Pharmacology and Toxicology, Schillingallee 70, 18055, Rostock, Germany

    Eigner, D. and D. Scholz (1999). Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal. Journal of Ethnopharmacology. Oct. 67(1): 1-6. {a} Sandoz Forschungsinstitut, A-1235, Vienna, Austria

    Garg, S. N., R. P. Bansal, et al. (1999). Variation in the rhizome essential oil and curcumin contents and oil quality in the land races of turmeric Curcuma longa of North Indian plains. Flavour and Fragrance Journal. Sept. Oct. 14(5): 315-318. {a} Garg Central Institute of Medicinal and Aromatic Plants, Lucknow, 226 015, India

    Gupta, A. P., M. M. Gupta, et al. (1999). Simultaneous determination of curcuminoids in Curcuma samples using high performance thin layer chromatography. Journal of Liquid Chromatography and Related Technologies. June 22(10): 1561-1569. {a} Central Institute of Medicinal and Aromatic Plants, Lucknow, 226 015, India

    Gupta, B. and B. Ghosh (1999). Curcuma longa inhibits TNF-alpha induced expression of adhesion molecules on human umbilical vein endothelial cells. International Journal of Immunopharmacology. Nov. 21(11): 745-757. {a} Molecular Immunology and Immunogenetics Laboratory, Centre for Biochemical Technology, University of Delhi, Mall Road, Campus (North), Delhi, 110007, India

    Kang, B. Y., S. W. Chung, et al. (1999). Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin. European Journal of Pharmacology. Nov. 384(2-3): 191-195. {a} College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Kwangju, 500-757, South Korea

    Kang, B. Y., Y. J. Song, et al. (1999). Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages. British Journal of Pharmacology. Sept. 128(2): 380-384. {a} College of Pharmacy, Chonnam National University, Kwangju, 500-757, South Korea

    Katiyar, R. S., B. Ram, et al. (1999). Response of turmeric to nitrogen and phosphorus application under intercropping system with poplar on sodic soils. Journal of Medicinal and Aromatic Plant Sciences. Dec. 21(4): 937-939. {a} National Botanical Research Institute, Lucknow, UP, 226001, India

    Kawamori, T., R. Lubet, et al. (1999). Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Research 59(3): 597-601. {a} American Health Foundation, Valhalla, NY 10595, USA

    Khanna, N. M. (1999). Turmeric: Nature's precious gift. Current Science Bangalore. May 76(10): 1351-1356. {a} 21/26, Tilak Marg, Near Moti Mahal East, Lucknow, 226 001, India

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