The Effect of Curcumin Differs on Individual
Cognitive Domains across Different Patient Populations: A
Systematic Review and Meta-Analysis
Pharmaceuticals | December 2021 Curcumin is a polyphenol with
strong antioxidant and anti-inflammatory activity. It is also
the primary active component of the Indian spice turmeric
(Curcuma longa)and curry powders. Animal studies have also
confirmed that curcumin has protective effects against cognitive
decline, both in aging rhesus monkeys and in a
streptozotocin-induced dementia rat model. Specifically,
curcumin has been found to exhibit various selective effects,
including preventing atrophic change and cell loss in the
prefrontal cortex compared to the hippocampus, decreasing
neuroinflammation compared to promoting neurogenesis, and more
positive effects on working memory than on recognition.
Following at least 8 weeks of nutritional supplementation,
curcumin was found to improve working memory more than a placebo
regimen. The results in the cognitive domain of processing speed
were notable, with a borderline p-value, which may be
significant if further trials are included. The protective
effect of curcumin in the prefrontal cortex has also been
demonstrated in animal models. Noorafshan et al. used three
different neural damage rat models, including stress-induced,
sulfite-induced, and sleep deprivation, and found that curcumin
could prevent structural deterioration in neurons and glial
cells, and could also counteract behavioral changes. This showed
that curcumin had a direct protective effect on the prefrontal
cortex and may explain why curcumin was able to effectively
improve working memory, as observed in our meta-analysis.
Turmeric
Root and Its Bioactive Ingredient Curcumin Effectively
Neutralize SARS-CoV-2 In Vitro Viruses |
December 2021 Turmeric root, also known as Curcuma longa,
is broadly used as a spice widely cultivated in Southeast Asia.
The rhizome of Curcuma longa contains several
structurally related curcuminoids. Sixty to 75% of the
curcuminoid content consists of curcumin, also known as
diferuloylmethane.As early as 1815, the bioactive ingredient
curcumin was first isolated from turmeric root by Vogel and
Pelletier. Curcumin reveals a broad spectrum of bioactivities
such as antioxidant, anti-inflammatory, antibacterial,
antiviral, antitumor, and hepatoprotective activities. In
addition to the antiviral activity, curcumin also exhibits
anti-inflammatory effects. Randomized controlled trials
indicated a significant downregulation of the human tumor
necrosis factor alpha (TNFα) and interleukin 6 (IL-6) through
curcumin.
Curcumin
Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by
Regulating Oxidative Stress and Neuro-Inflammatory Proteins in
the Prefrontal Cortex Region of the Brain
Antioxidants | February 20 Curcumin is an active component of
turmeric (Curcuma longa) which is widely used as a food
additive in Indian cuisines and Ayurvedic medicines. Previously,
researchers have reported the neuroprotective effect of curcumin
in various neurodegenerative diseases. In our study on dim
light-induced neurodegeneration, we have shown the antioxidant
effects of curcumin. Other researchers have also highlighted the
anti-inflammatory and antioxidant effects of curcumin. Curcumin
plays an effective role as a natural therapeutic drug to combat
Cd-induced behavioral impairment by regulating oxidative stress
and modulating inflammatory markers. Curcumin was found to
improve the behavior of mice through reduction of prefrontal
cortex oxidative stress and neuroinflammation as well as
promotion of hippocampal neurogenesis. Therefore, curcumin
supplementation in food and diet could reduce the deleterious
effect of heavy metal exposure.
Antiviral Therapeutic Potential of Curcumin
Molecules | December 2021 Curcumin
(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione),
also called diferuloylmethane, is the best example of a plant
derivative with an enormous number of therapeutic properties,
such as anti-oxidant, anti-carcinogenic, anti-diabetic,
anti-microbial, and antiviral activity. In traditional Indian
Ayurvedic medicine, curcumin was widely applied in many
therapeutic remedies. This compound is a natural polyphenolic
substance and an active form of the traditional herb that is
found in the rhizome of Curcuma longa (turmeric).
Curcumin is the main molecule of the curcuminoids; the
curcuminoids are comprised of curcumin (77%) as well as includes
bisdemethoxycurcumin (BDMC) (17%) and demethoxycurcumin (DMC)
(6%). The first suggestion that curcumin had antiviral
properties came in the 1990s, with the discovery that curcumin
and curcumin boron complexes could inhibit the human
immunodeficiency virus (HIV). Since then, numerous studies have
found that curcumin has antiviral activity against a diverse set
of viruses, including both RNA and DNA viruses, both enveloped
and non-enveloped. Multiple selected studies were on different
types of human viruses, including human immunodeficiency virus
(nine studies), hepatitis C virus (five studies), human
cytomegalovirus (three studies), hepatitis B virus (four
studies), herpes simplex viruses (four studies), dengue virus
(four studies), enterovirus 71 (two studies), human T lymphocyte
virus (two studies), vesicular stomatitis virus (two studies),
and respiratory syncytial virus (two studies). There was one
study for viruses including zika and chikungunya, coronavirus,
Rift Valley fever virus, human norovirus, coxsackievirus B3,
Japanese encephalitis virus, and viral hemorrhagic septicemia
virus. 27 studies showed that curcumin reduced the
production of infectious particles in various infected cells in
a dose-dependent manner.
Curcumin
supplementation improves biomarkers of oxidative stress and
inflammation in conditions of obesity, type 2 diabetes and
nonalcoholic fatty liver disease (NAFLD)
Food & Function | December 2021 A systematic search, through
prominent online databases such as MEDLINE, Scopus, and Google
Scholar was done focusing on randomized controlled trials (RCTs)
reporting on the impact of curcumin supplementation in
individuals with diverse metabolic complications, including
obesity, type 2 diabetes and nonalcoholic fatty liver disease.
Summarized findings suggest that curcumin supplementation can
significantly reduce blood glucose and triglycerides levels,
including markers of liver function like alanine
aminotransferase (ALT) and aspartate aminotransferase (AST) in
patients with type 2 diabetes and nonalcoholic fatty liver
disease. Importantly, this effect was consistent with the
reduction of predominant markers of oxidative stress and
inflammation, such as the levels of malonaldehyde (MDA), tumor
necrosis factor-alpha (TNF-α), high sensitivity C-reactive
protein (hs-CRP) and monocyte chemoattractant protein-1 (MCP-1)
in these patients. RCTs suggest that curcumin is beneficial in
ameliorating some metabolic complications.
Curcumin
as a Possible Treatment for COVID-19-Induced Anosmia and Ageusia
Cureus | December 2021 Curcumin, the main component of the
spice turmeric, is derived from the rhizome of the plant
Curcuma longa. Beneficial effects of curcumin have been
reported over centuries in the treatment of various ailments,
from oncological to autoimmune disorders. Curcumin has been
observed to block pro-inflammatory regulators and signaling
pathways, including inhibiting nuclear factor (NF)-kappa B
activation and suppressing tumor necrosis factor-alpha (TNF-α),
interleukin 1 beta (IL-1β), interleukin 6 (IL-6), monocyte
chemotactic protein-1 (MCP-1), prostaglandin E2, and
cyclooxygenase-II, among others. Curcumin has been shown to bind
and block the active site of Mpro, the main protease utilized by
COVID-19 to produce proteins required for viral replication from
viral genomic RNA. Curcumin may also hinder the formation of the
COVID-19 spike protein-ACE2 complex, preventing viral entry into
cells. The anti-inflammatory action of curcumin may reduce nasal
mucosal swelling.
Antioxidant effects of curcumin and neuroaging
Genetics, Neurology, Behavior, and Diet | December 2021
Curcumin, a plant-based polyphenol, is known to scavenge free
radicals and promote antioxidant activity. This chapter gives an
overview of the molecular
evidence by brain imaging studies is reviewed. There is
preliminary evidence for curcumin improving memory and
decreasing amyloid-β plaque accumulation. Consequently, curcumin
has potential as a therapy in aging and aging-related disorders.
Curcumin
in Metabolic Health and Disease Nutrients
| December 2021 In recent years, epidemiological studies have
suggested that metabolic disorders are nutritionally dependent.
A healthy diet that is rich in polyphenols may be beneficial in
the treatment of metabolic diseases such as polycystic ovary
syndrome, metabolic syndrome, non-alcoholic fatty liver disease,
cardiovascular disease, and, in particular, atherosclerosis.
Curcumin is a polyphenol found in turmeric and has been reported
to have antioxidant, anti-inflammatory, hepatoprotective,
anti-atherosclerotic, and antidiabetic properties, among others.
Targets of Curcumin against Colorectal Cancer and
the Correlation with Tumor-Infiltrating Immune Cells
Evidence-Based Complementary and Alternative Medicine | December
2021 In recent years, more and more studies have shown that
curcumin has great potential in the treatment of colorectal
cancer. Curcuma longa L., commonly known as turmeric,
is a rhizomatous herb of the ginger (Zingiberaceae)
family. Curcumin is a lipophilic polyphenol compound extracted
from the Zingiberaceae family, which lowers blood glucose and
has anticancer, anti-inflammation, and antiaging effects.
Howells et al. confirmed that curcumin is a safe and
well-tolerated adjuvant chemotherapy drug for folinic
acid/5-fluorouracil/oxaliplatin chemotherapy (FOLFOX)
chemotherapy of metastatic colorectal cancer. In a clinical
trial, curcumin has been proved to promote the transformation of
Treg cells to Th1 cells and enhance the production of
interferon-γ, supporting the antitumor effect of curcumin in
colorectal cancer. The clinical efficacy of curcumin in the
treatment of colorectal cancer has been recognized. Subsequent
in vivo experiments confirmed that curcumin can reduce
inflammation and colorectal cancer formation in mouse models.
These research results showed that curcumin has many potential
effects and has definite therapeutic effects on colorectal
cancer . In conclusion, in this study, we identified the key
targets of curcumin in colorectal cancer inhibition through the
combination of network pharmacology, molecular docking, and
tumor immune microenvironment analysis. The mechanism of action
of curcumin is binding to AKT1, STAT3, and EGFR by hydrogen
bond, hydrophobic effect, and π-cation bond.
The Functional Roles of Curcumin on Astrocytes in
Neurodegenerative Diseases
Neuroimmunomodulation | December 2021 Curcumin is the main
component of a yellow pigment, commonly called
diferuloylmethane, and is an active ingredient in the rhizome of
the herb Curcuma longa that represents various biomedical
applications. Curcumin has also been traditionally used for its
medicinal benefits and wound healing for centuries. However, it
was first applied as a drug to treat biliary disease in 1937.
Curcumin is a lipophilic polyphenol that is relatively stable in
the acidic pH but decomposes in neutral-basic conditions.
Curcumin contains approximately 77% diferuloylmethane, 17%
dimethoxycurcumin, and 6% bisdemethoxycurcumin. Nowadays,
curcumin (C21H20O6) has important roles in the attenuation of
progression of some NDs because of its anti-amyloid and
anti-inflammatory agents. In addition, curcumin also has several
benefits, such as being safe, inexpensive, and readily available
polyphenol that can cross the blood brain barrier, thus
attracting researchers to use it for treating neurodegenerative
diseases. Curcumin is an NF-κB inhibitor by interrupting
ZO-1 expression and localization, MLC phosphorylation, and ROS
generation inhibition, which constrains disruption of the BBB by
Th17 cells. Furthermore, curcumin, through its NF-κB inhibitory
effect, causes intestine dendritic cell differentiation into
tolerogenic phenotypes, as well as naive T cells to
differentiate into FoxP3+ regulatory T cells (intestine
protective, Treg). Thus, curcumin can prevent colitis, due to
its anti-inflammatory function. Curcumin has a critical role in
transcription factor regulation. Furthermore, curcumin can
regulate cytokines, adhesion molecules, protein kinases, redox
status, and inflammation-associated enzymes. The pharmacological
activities of curcumin are antimicrobial, anti-inflammatory,
antioxidant, and anticarcinogenic. It also exhibits potent
immunoregulatory activities that can modulate the T cells, B
cells, neutrophils, natural killer cells, and macrophage
activation and function. Curcumin has been shown to be
protective for several cells, including astrocytes, neurons,
microglia, and different part of the CNS such as hippocampal,
mesencephalic, cortical, and spinal cord. A multiple sclerosis
study showed that curcumin regulates T-cell responses to IL-12
by blocking IL-12 production, and IL-12 signaling, through
inhibiting JAK-STAT signaling activation. Thus, it has been
suggested that curcumin could be used for treating multiple
sclerosis and other Th1-cell-mediated inflammatory diseases.
Furthermore, curcumin at high doses can directly induce T-cell
apoptosis and inhibit T-cell proliferation through blocking of
the IL-2 signaling pathway, high-affinity IL-2R, and interfering
with IL-2R signaling. These data indicate that curcumin has
immunosuppressive effects on many pathways. Thus, curcumin,
through its proinflammatory cytokines, decreases TNF-α/β, IL-1,
IL-6, and IL-8, and COX-2 provides a therapeutic effect by
reducing inflammatory conditions. Curcumin can cross blood brain
barrier and, by inhibiting proinflammatory cytokines, can
regulate homeostasis of the CNS. The blood brain barrier has a
crucial role in controlling the homeostasis of the brain
microenvironment. Thus, because autoreactive T-cell penetration
plays a key role in MS lesion development, the role of curcumin
to protect the blood brain barrier could reduce the severity of
MS. Curcumin also decreases the severity of chronic inflammatory
diseases, such as rheumatoid arthritis, asthma, AD, and cancer.
In phase II clinical trial, curcumin was used orally in a mouse
model of colorectal cancer. It has been demonstrated that
curcumin can prevent carcinogenesis through different mechanisms
such as reduction of cyclooxygenases 1 and 2, 5-lipoxygenase,
prostaglandin E2 (PGE2), and 5-hydroxyeicosatetraenoic acid
production inhibition. Fortunately, curcumin via inhibition of
NF-κB signaling pathways can improve the effects of some
chemotherapy drugs. For example, in the mouse model of human
breast cancer, curcumin, in conjunction with paclitaxel, can
slow breast cancer progression and metastasis to the lung.
According to Alavez et al., curcumin, through its involvement in
the regulation of protein homeostasis, can increase life span in
several species. Curcumin, as a natural cost-effective product
with proven pharmacological safety, has strong antioxidant and
anti-inflammatory effects through modulating many cellular
signaling pathways.
Effect of curcumin supplement or placebo in delayed
onset muscle soreness: a systematic review and meta-analysis
Bulletin of the National Research Centre | December 2021
Curcumin is a natural polyphenolic substance extracted from
turmeric. It has various physiological effects, such as membrane
protective effects
and tumor necrotic factor TNF-α. This review suggested that
persons who took curcumin supplement before exercise have pain
score of about 1 score lower than those who took placebo in and
post-exercise at 1, 2, 3 and 4 days. For indirect markers of
muscle damage, the persons who took curcumin supplement before
exercise have lower CK, TNF and IL score than those who took
placebo. From a review of previous meta-analysis (Fang and Nasir
2021), curcumin has efficacy in reducing CK serum levels and
muscle soreness index among adults. Therefore, curcumin may be
known as a priority EIMD recovery agent in interventions.
To conclude, curcumin supplement has reduced muscle soreness and
CK after exercise after 1, 2, 3, and 4 days when compared to
placebo.
Curcumin
and Its Potential Impact on Microbiota
Nutrients | December 2021 Curcumin is a polyphenol substance
isolated from the rhizome of Zingiberaceae and Araceae plants.
It is a major active constituent of turmeric, a common Asian
spice used as a dietary spice, food-coloring, as a herbal
remedy, and in the beverage industries. Its bioactive components
have been investigated recently [1,2]. Diferuloylmethane
(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione),
which is commonly referred to as curcumin, has been shown to
have activity at the cellular level, by signaling multiple
molecules. In addition it exerts antioxidant and
anti-inflammatory properties. It may have many therapeutic
effects, having exhibited antitumor, chemosensitizing,
hepatoprotective, lipid-modifying, and neuroprotective effects.
Piperine is a natural alkaloid that is found in black pepper intestine. As Hewlings and Kalman emphasized in their
work, piperine has been associated with an increase in the
bioavailability of curcumin by 2000%. Polyphenols, such as
curcuminoids, are naturally occurring bioactive compounds that,
due to their antioxidant abilities, play important roles in
human nutrition. A substantial amount of promising evidence has
indicated that curcumin may be capable of preventing and
combating several metabolic syndromes, cancer, and obesity, and
may even play a neuroprotective role. The metabolism of
curcumin, which occurs in the intestine, enhances its biological
activity and, as a consequence, biotransforms it into active
metabolites, which may promote beneficial effects in the gut
microbiota.
Curcumin as a great contributor for the treatment
and mitigation of colorectal cancer
Experimental Gerontology | December 2021 This review mainly
brings out the correlation between the curcumin and its use for
the mitigation of colorectal cancer, the use of curcumin as a
chemotherapeutic agent, chemosensitizer, and in a combination
and synergistic approach. The pharmacokinetics and
pharmacodynamics properties of curcumin and its formulation
approach helps in giving an idea to develop new approaches for
the treatment of colorectal cancer using curcumin.
Protective effect of the association of curcumin
with piperine on prostatic lesions Food and
Chemical Toxicology | December 2021 Curcumin plus piperine
reduce malignant effects of BPA in prostate. Inflammation provoked to BPA in the prostate was
minimized by curcumin and piperine. Curcumin and piperine helped
to minimize carcinogenesis. Thus, these phytochemicals minimize
the deleterious action of BPA in prostatic lobes, especially
when administered in association. The protective action of
curcumin and piperine consumption is associated with weight
loss, anti-inflammatory potential, and control of prostate
epithelial cell homeostasis.
The effect of Curcumin on multi-level immune
checkpoint blockade and T cell dysfunction in head and neck
cancer Phytomedicine | December 2021
This study evaluated the immune-modulating effects of Curcumin,
which has well-established anti-cancer and chemopreventive
properties, and its long-term safety as a phytochemical drug. We
found that Curcumin decreased the expression of IC ligands such
as PD-L1, PD-L2, and Galectin-9 in HNSCC, leading to regulation
of epithelial-to-mesenchymal transition-associated tumor
invasion. Curcumin also effectively restored the ability of CD8+
cytotoxic T cells to lyse cancer cells. To evaluate the effect
of Curcumin on the TME further, the 4-NQO oral cancer model was
used. Curcumin increased T-cell proliferation,
tumor-infiltrating lymphocytes (TILs), and effector cytokines,
and decreased the expression of PD-1, TIM-3, suppressive IC
receptors and their ligands (PD-L1, PD-L2, and Galectin-9) in
the TME, implying reinvigoration of the exhausted CD8+ T cells.
In addition, Curcumin inhibited expression of CD4+CD25+FoxP3+
Treg cells as well as PD-1 and TIM-3. These results show that
Curcumin reinvigorates defective T cells via multiple (PD-1 and
TIM-3) and multi-level (IC receptors and its ligands) IC axis
suppression, thus providing a rationale to combine Curcumin with
conventional targeted therapy or ICB as a multi-faceted approach
for treating patients with HNSCC.
The efficacy of high and low dose curcumin in knee
osteoarthritis: A systematic review and meta-analysis
Complementary Therapies in Medicine | December 2021
Curcuminoids have been shown to possess multiple pharmacological
effects, such as anti-inflammatory, anti-oxidative,
anti-hyperlipidaemic, and anti-platelet effects, and also to
relieve pain and reduce swelling. These properties can be
attributed to curcumin acting as an inhibitor of the nuclear
factor-kappa β (NF-κβ) pathway and a scavenger of reactive
oxygen and nitrogen species. Curcuminoids are employed as
adjunctive treatment for rheumatoid arthritis, degenerative
neural disease, some cancers, and polycystic ovary disease.
Recent randomized controlled trials) have revealed that curcumin
has similar effects on pain relief NSAID may lower
the NSAID dosage needed and reduce its side effects.
Additionally, a recent study by Shep et al. reported less rescue
medication use and fewer AEs in patients taking combined
curcuminoid and diclofenac than in those taking diclofenac
alone. Previous meta-analyses have shown that curcuminoids have
beneficial effects on knee OA. Low- and high-dose curcuminoids
have similar pain relief effects and adverse events in knee OA.
Curcuminoids are associated with better pain relief than
non-steroid anti-inflammatory drugs.
Effects of curcumin supplementation on inflammatory
biomarkers in patients with Rheumatoid Arthritis and Ulcerative
colitis: A systematic review and meta-analysis
Complementary Therapies in Medicine | December 2021
Furthermore, more duration (> 8 weeks) and
more dosage of curcumin (more than 500 mg) is more related to
reduction in ESR and CRP in adult patients with rheumatoid
arthritis and ulcerative colitis in comparison with the control
group.
Curcumin prevents arsenic-induced carcinogenesis
Chinese Medical Journal | December 2021 Curcumin, an acidic
polyphenol compound has anti-inflammatory and anti-tumor
effects. This natural chemopreventive agent, derived from
rhizomes of curcuma species, provides antioxidant, anti-tumor,
and anti-proliferative efficacy. Curcumin blocks cancer
development by modulating multiple signaling pathways.
Researchers have previously provided novel perceptions about the
mechanisms of curcumin action in gastric cancer cell growth
inhibition and its therapeutic strategies for gastric cancer
control. Therefore, curcumin could be considered a novel
therapeutic strategy to control gastric cancer cell growth. Some
studies have emphasized the importance of curcumin in lung
cancer treatment and the potential utility of curcumin as a
method for improving therapeutic outcome. Curcumin suppressed
gemcitabine-resistant non-small cell lung cancer cell
proliferation and induced apoptosis. Curcumin upregulated the
expression of lncRNA-MEG3 and PTEN. Previous studies have also
showed that curcumin has potential clinical application in
gemcitabine-resistant non-small cell lung cancer treatment for
its anti-tumor activity. Furthermore, curcumin also showed
anti-inflammatory activity in the kidney. Another study
identified curcumin as a common inhibitor of NLRP3 inflammasome
activation and revealed that curcumin repressed inflammation. In
view of the various advantages and characteristics of curcumin,
its anti-tumor effect has attracted the attention of
researchers, and has good application prospect in the prevention
and treatment of lung cancer. Curcumin, a major yellow pigment
and spice in turmeric and curry, is a powerful anti-cancer
agent. The anti-tumor activities of curcumin include inhibition
of tumor proliferation, angiogenesis, invasion, and metastasis,
induction of tumor apoptosis, increase in chemotherapeutic
sensitivity, and regulation of cell cycle and cancer stem cells,
indicating that curcumin has strong therapeutic potential in
modulating the progression of various cancers. Numerous studies
have provided evidence that curcumin protects against
neurotoxicity, genotoxicity, and DNA damage in vivo and in
vitro. To date, more than 100 clinical trials have been
completed with curcumin, all of which have demonstrated its
safety, tolerability, and effectiveness against various chronic
diseases, including various cancers, diabetes, obesity, and
cardiovascular, pulmonary, neurological, and autoimmune diseases
in humans. Curcumin may represent a useful supplement to improve
chronic inflammation and prevent carcinogenic changes in
patients. These studies have indicated that curcumin is a
promising molecule for the prevention and treatment of cancer.
In summary, in the first stage of As3+-induced carcinogenesis,
curcumin activates Nrf2, decreases ROS, and induces autophagy in
normal cells to prevent As3+-induced cell transformation. In the
second stage, curcumin inhibits constitutive expression of Nrf2
and promotion of ROS, apoptosis, and inhibition of angiogenesis
in AsT cells to prevent tumorigenesis. Our results suggest that
antioxidant natural compounds such as curcumin should be
evaluated further as potential candidates for complementary
therapy for As3+-induced carcinogenesis.
Improvement
of intestinal barrier function, gut microbiota, and metabolic
endotoxemia in type 2 diabetes rats by curcumin
Bioengineered | November 2021 Curcumin is a natural
polyphenol compound extracted from Curcuma tuber and Curcuma
rhizome. It is believed to possess the ability of anti-tumor,
anti-inflammatory, antioxidant and anti-fibrosis effects.
Studies have shown that curcumin could inhibit nuclear factor-κB
(NF-κB) mediated interleukin-1β (IL-1β) and tumor necrosis
factor α (TNF-α) release in db/db diabetic mice, and further
reduce the inflammatory reaction of mouse liver. In obese rats
fed with high fat diet and obese mice with leptin gene
deficiency, curcumin can inhibit the secretion of TNF and
monocyte chemoattractant protein-1 (MCP-1), improve inflammatory
response, and reduce the levels of blood glucose and
glycosylated hemoglobin. Clinical trials indicated that oral
curcumin can improve the function of islet B cells in
prediabetic patients, reduce insulin resistance, prevent
progression to type 2 diabetes. Therefore, curcumin has good
clinical application prospects. In this study, we demonstrated
that curcumin could improve the intestinal integrity in the type
2 diabetes animal model, and promoted the expression of ZO-1 and
occludin. In addition, the hyperglycemia and insulin resistance
of type 2 diabetes rats were relieved by curcumin. The
suppressive effect of curcumin on TLR4/NF-κB was also observed.
Curcumin also improve the gut microbiota dysbiosis in type 2
diabetes Some studies have indicated the protective role of
curcumin in intestinal barrier of diabetes. Their conclusions
that curcumin could improve the intestinal barrier function are
in line with our study. In this study, we found that the
significant increase of LPS caused by HFD could be remarkably
reduced by curcumin. We demonstrated that curcumin could improve
the intestinal barrier function, gut microbiota, and metabolic
endotoxemia in type 2 diabetes rats. Therefore, curcumin might
be a potential therapeutic agent for the treatment of type 2
diabetes.
Neuroprotective Effects of Curcumin in
Methamphetamine-Induced Toxicity Molecules
| November 2021 Curcumin, a natural polyphenol
extracted from rhizome of the Curcuma longa L, has received
great attention for its multiple potential health benefits as
well as disease prevention. For instance, curcumin protects
against toxic agents acting on the human body, including the
nervous system. In detail, curcumin possesses, among others,
strong effects as an autophagy activator. The present data
provide evidence that curcumin counteracts the neurotoxic
effects induced by methamphetamine by promoting autophagy.
In recent years, curcumin has received great attention for its
multiple potential health benefits as well as disease
prevention. Curcumin has been explored for its multiple
biological activities mostly focusing on autophagy activation,
which is considered to be relevant to counteract various
toxicants and disease conditions.
Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero
E6 Cells through Multiple Antiviral Mechanisms
Molecules | November 2021 Curcumin, the main polyphenolic
compound of turmeric, has attracted significant attention owing
to its biological effects, such as anti- tumor,
anti-inflammatory, immunomodulating, antioxidant, antimicrobial,
and antiviral activities; therefore, it has been proposed that
curcumin may be a potential treatment against COVID-19. Notably,
it has been observed that the consumption of curcuminoids
leads to a significant reduction in circulating levels of
C-reactive protein and decreases the expression of
proinflammatory cytokines, including IL-1β, IL-6, IL-8, and
TNF-α, demonstrating its anti-inflammatory capacity; it is
important to highlight that this cytokines has been correlated
with severe illness. Moreover, in macrophages, it has been
observed that curcumin inhibits NLR family pyrin domain
containing 3 (NLRP3) inflammasome activation, which plays a
significant role in the development of inflammatory diseases.
Additionally, curcumin exhibits its inhibitory activity against
the replication of diverse viruses, such as dengue virus,
hepatitis B virus, zika virus, influenza A virus, and chikungunya virus. Curcumin can exert antiviral effects directly on
the viral particle or at different stages of the replicative
cycle by interacting with viral proteins or by modulating
cellular processes or pathways crucial for viral replication.
Specifically for SARS-CoV-2, studies in silico (computer
modeling) have reported that curcumin exhibits favorable
binding affinities with the spike protein of the virus, as well
as with its main cellular receptor, ACE2. These results suggest
that curcumin has the ability to interfere with the entry of the
virus into the cell. Furthermore, it has been reported that
curcumin can affect the expression of other key molecules in the
entry and decay of the virus, such as TMPRS22, Cat B, and L. The
cumulative evidence suggests that curcumin could be an effective
treatment strategy to complement the COVID-19 clinical
management. Further, it has been persistently reported that
curcumin has anti-inflammatory effects on in vivo models, such
as atherosclerosis, multiple sclerosisnd inhibiting the production of
pro-inflammatory cytokines and chemokines. In this sense, it has
been shown that despite the low bioavailability of curcumin, in
two models of chronic disease, this compound has
anti-inflammatory effects at low doses, via IL-10 production.
Moreover, the ability of curcumin to alter the inflammatory
state through the modulation of its regulatory elements can
prevent the onset of the cytokine storm. Evidence presented in this
article suggests that curcumin represents a promising compound
for developing therapy against SARS-CoV2. In this study,
curcumin showed high cytotoxicity at 20 µg/mL in Vero E6 cells. In conclusion,
curcumin showed in vitro antiviral activity against SARS-CoV-2,
with different treatment strategies, which suggest the
inhibition at different stages of the replicative cycle;
furthermore, these effects seem to be independent of the virus
strain/variant. This antiviral effect, together with the
observed immunomodulatory properties, suggests that curcumin
could be a promising compound for the treatment of COVID-19
patients.
Effects of Curcumin on Aging: Molecular Mechanisms
and Experimental Evidence BioMed Research
International | November 2021 Several lines of evidence
highlighted a pleiotropic potential of curcumin towards several
human diseases, such as malignancies, skin and immune-related
disorders, cardiovascular diseases, pulmonary and renal
fibrosis, nonalcoholic fatty liver disease (NAFLD), fatigue,
neuropathic pain, bone and muscle loss, neurodegenerative
disease, ocular diseases, leprosy, osteoporosis, leishmaniosis,
and HIV infection. Curcumin supplementation in human melanoma
cells induces growth arrest and then apoptosis. Other studies
also reported that curcumin may target oncogene expression,
angiogenesis, invasion, and metastatic dissemination. Alongside
with antitumorigenic activity, curcumin was also shown to induce
antimicrobial, antioxidant, antiglycemic, antiseptic, and
analgesic effects. With regard to inflammation, curcumin
stimulates a xenobiotic response with upregulation of defense
genes and suppression of proinflammatory transcription factors
and cytokines. Moreover, several studies indicated that curcumin
and may be used as senolytic and anti-inflammatory agents for
senescent cells. As reported by Banji et al.,
curcumin(40 mg/kg) and piperine (12 mg/kg), especially when
combined, counteract D-gal-induced senescence in male Wistar
rats by targeting OS and lipofuscin deposition, finally leading
to higher hippocampal volume and function with improved spatial
memory. Aging and senescence are complex processes
leading to organ dysfunction. Despite being permanent, delaying
the occurrence of these processes is a reliable target, and
curcumin might be a promising candidate for this purpose.
Nevertheless, evidence from clinical studies on the long-term
effects of curcumin on age-related pathological events remains
largely understudied. While several strategies to enhance the
systemic bioavailability of curcumin have been suggested, the
effects of long-term therapy with such bioavailability-boosted
curcumin preparations is not fully known, and increased
concentrations may even lead to opposite results. Pleiotropic
benefits of curcumin supplementation involve the control of
aging genes, OS, and inflammation in both the vascular system
and the central nervous system. Further studies are warranted to
clarify the mechanisms of curcumin function for potential
clinical application.
Is Curcumin the Answer to Future Chemotherapy
Cocktail? Molecules | November 2021
Curcumin, also regarded as diferuloylmethane, is a yellow
polyphenol extracted from the rhizome of the Curcuma longa
(turmeric) plant, belonging to the Zingiberaceae
family. Indigenous in south-eastern and southern tropical Asia,
curcumin is traditionally applied for pain-relieving and wound
healing effects. Commercial curcumin products contain
approximately 77 % curcumin, 18 % demethoxycurcumin and 5 %
bisdemethoxycurcumin. Out of those curcuminoids, curcumin
exhibits the most potent medicinal properties as compared to
demethoxycurcumin and bisdemethoxycurcumin. A growing body of
evidence has demonstrated the benefits of curcumin in treating
various diseases, including metabolic syndromes, hyperlipidaemia,
inflammatory skin conditions, neurodegeneration and rheumatoid
arthritis. These clinical benefits are attributed to the
anti-inflammatory, anti-oxidant, and wound healing activities of
curcumin. Moreover, curcumin can impede pathogenic infections by
exerting a broad spectrum of anti-bacterial, anti-fungal and
anti-viral activities. Enormous
attention has given to the exploration of anticancer properties
in curcumin. To date, curcumin has shown its anticancer benefits
in numerous cancers such as breast cancer, colorectal cancer,
lung cancer, pancreatic cancer and prostate cancer. In fact,
these anticancer effects depicted by curcumin are highly
associated with the modulation of several oncogenic signalling
pathways, which are essential in cancer development. Curcumin
constrains these oncogenic signalling pathways and further
limits the downstream pro-tumorigenic activities. In vitro
studies illustrated that curcumin treatment limited the
proliferation and caused cell cycle arrest in HT-29 colon cancer
cells and PLC/PRF/5 liver cancer cells via the inhibition of
cyclin D1, with the downregulation of NF-κB and cyclooxygenase-2
(COX-2) signalling. pathways and inhibition of MMP
activities. Apart from limiting the expression of IAP family
proteins, curcumin promotes the apoptosis of cancer cells by
increasing the expression of Bax while downregulating the
expression of Bcl-2 in various cancer cells. It has also been
shown to be able to abrogate angiogenesis elicited by breast
tumors via the suppression of VEGF. Lately, curcumin has gained
a great deal of interest, attributed to its broad range of
medicinal properties. Intriguingly, curcumin exhibited countless
anticancer properties, such as limiting cancer cell
proliferation, promoting tumor cell death and preventing
metastasis. Besides, curcumin supplementation greatly relieves
the patients from experiencing adverse effects caused by
conventional therapies. Hence, these properties pose great
advantages to the development of curcumin combination therapy
for cancer treatment. This review focuses on the use of curcumin
in combination therapy in various cancers. The evasive
mechanisms developed by cancer cells in response to cancer
therapy are discussed. Curcumin combination therapies used are
reviewed in depth in each type of cancer in both preclinical and
clinical studies. We also addressed how curcumin modulates a
variety of molecular targets in cancer cells in the combination
treatment, to provide an insight into the multitargeting effects
of such treatment cocktails.
Curcumin inhibits ovarian cancer progression
Journal of Ovarian Research | November 2021 Curcumin is the
active component of turmeric which has an anti-cancerous
property in multiple cancers, including ovarian cancer. It can
exhibit the anti-cancer role in ovarian cancer by decreasing
tumorigenesis and increasing the efficiency of
radio-chemotherapy. Curcumin suppressed ovarian cancer cell
proliferation and promoted apoptosis. Circ-PLEKHM3 was
downregulated in ovarian cancer, and its expression could be
promoted by curcumin treatment. Circ-PLEKHM3 overexpression
exacerbated the effect of curcumin on ovarian cancer cell
proliferation and apoptosis, as well as anti-tumor effect.
MiR-320a was targeted by circ-PLEKHM3. The inhibition effect of
circ-PLEKHM3 overexpression on cell proliferation and the
enhancing effect on cell apoptosis could be reversed by miR-320a
mimic. SMG1 was targeted by miR-320a, and its knockdown also
reversed the regulation of miR-320a inhibitor on the
proliferation and apoptosis of ovarian cancer cells. In
addition, circ-PLEKHM3 could upregulate SMG1 expression via
sponging miR-320a.
Anti-Inflammatory Effects of Curcumin in the
Inflammatory Diseases Drug Design,
Development and Therapy | November 2021 Curcumin is a natural
compound with great potential for disease treatment. A large
number of studies have proved that curcumin has a variety of
biological activities, among which anti-inflammatory effect is a
significant feature of it. The anti-inflammatory effect of
curcumin can effectively improve the symptoms of these diseases
and is expected to be a candidate drug for the treatment of
related diseases. Curcumin has anti-inflammatory,
anti-oxidant, anti-tumor and other biological activities. The
anti-inflammatory properties of curcumin are considered to be
the basis of its various biological activities and play an
important role in the treatment of diseases. Curcumin is mainly
derived from the root tuber of Curcuma aromatica Salisb and the
rhizome of C. longa L. (Turmeric) of Zingiberaceae.
Turmeric is a common spice in India and has been described in
Ayurveda, as a treatment for inflammatory diseases. In western
herbalism, turmeric is primarily used as an anti-inflammatory
agent.3 Curcumin and curcuminoids, the active components of
turmeric, are found as effective therapies over the years.
Curcumin, demethoxycurcumin and bisdemethoxycurcumin, these
three compounds are called curcuminoids. In addition,
curcumin-containing dietary supplements are extremely popular,
and there are many anti-oxidant and anti-inflammatory curcumin
dietary supplements on the market.In conclusion, curcumin has good
anti-inflammatory properties, and curcumin regulates NF-κB,
MAPK, AP-1, JAK/STAT and other signaling pathways, and
inhibiting the production of inflammatory mediators. Curcumin in
the treatment of IBD, arthritis, psoriasis, depression and
atherosclerosis and other diseases, can reduce inflammatory
response, effectively improve symptoms, play a role in the
treatment of diseases. Now, the pharmacokinetics and
anti-inflammatory effects of curcumin have been improved to some
extent by the structural modification and modification of
curcumin, preparation research and drug combination therapy.
Among them, curcumin dietary supplement or adjuvant drug has
significant therapeutic effect, which is the most feasible way
for curcumin application at present.
Oral Curcumin With Piperine as Adjuvant Therapy for the
Treatment of COVID-19 Frontiers in
Pharmacology | November 2021 Patients with mild, moderate, and
severe symptoms who received curcumin/piperine treatment showed
early symptomatic recovery (fever, cough, sore throat, and
breathlessness), less deterioration, fewer red flag signs,
better ability to maintain oxygen saturation above 94% on room
air, and better clinical outcomes compared to patients of the
control group. Patients received curcumin-piperine capsules
(three capsules/day; each capsules containing 500 mg curcumin
plus 5 mg piperine; in total 1500 mg curcumin and 15 mg
piperine/daily). Furthermore, curcumin/piperine treatment
appeared to reduce the duration of hospitalization in patients
with moderate to severe symptoms, and fewer deaths were observed
in the curcumin/piperine treatment group. Administration
of oral curcumin with piperine as an adjuvant symptomatic
therapy in COVID-19 treatment could substantially reduce
morbidity and mortality, and ease the logistical and
supply-related burdens on the healthcare system. Curcumin could
be a safe and natural therapeutic option to prevent Post-Covid
thromboembolic events. Orally administered curcumin with
piperine could play a multifaceted role in the treatment of
COVID-19. The anti-inflammatory and anti-thrombotic properties
of curcumin could expedite the recovery of COVID-19 patients,
and its antiviral, antibacterial, and antifungal properties
could prevent superadded or secondary infections. Our results
suggest that the use of orally administered curcumin with
piperine as adjuvant therapy in COVID-19 treatment could
substantially reduce morbidity and mortality, reduces treatment
costs, and decrease logistical burden healthcare systems.
Dose-escalating studies have indicated the safety of curcumin
over 3 months. Hence, Curcumin can be a safe and natural
therapeutic option to prevent Post-Covid thromboembolic events.
Curcumin induces apoptosis through caspase dependent
pathway in human colon carcinoma cells
Molecular Biology Reports | November 2021 We investigated the
apoptotic effects of curcumin in the colon carcinoma cell line
SW480. The proportion of BrdU-stained cells in the control
groups were 58%, 57% and 61% and 28%, 27%, and 30% in the
curcumin treatment groups at 24, 48, and 72 h, respectively. The
proportion of apoptotic cells was 28%, 29%, and 28% in the
control groups and 59%, 61%, and 60% in the curcumin treatment
groups at 24, 48, and 72 h, respectively. As expected, caspase-3
staining also revealed a higher number of apoptotic cells in
curcumin treatment groups at 24, 48, and 72 h compared to
controls. These results suggest that curcumin may be a potential
protective or treatment agent against colon cancer.
The emerging role of curcumin for improving vascular
dysfunction Critical Reviews in Food
Science and Nutrition | November 2021 Clinical intervention
studies with curcumin have demonstrated significant improvements
in endothelial function, arterial compliance, arterial
stiffness, and other measures of vascular hemodynamics in young,
middle-aged, old, post-menopausal, healthy, diabetic, and obese
individuals. Mechanistically, curcumin is believed to improve
vascular function through its effects on inflammation, oxidative
stress, nitric oxide bioavailability, and structural proteins of
the artery. Current data give support for curcumin to be
administered for improvements in vascular health to individuals
that may or may not be at risk for cardiovascular disease. This
review briefly summarizes the techniques used for the
establishment of vascular health and overviews the literature
investigating the role of curcumin in the improvement of
vascular health.
Curcumin enhances drug sensitivity of
gemcitabine-resistant lung cancer cells and inhibits metastasis
Pharmazie International Journal of Pharmaceutical Sciences |
November 2021 This study aimed to investigate the effects of
curcumin on the proliferation, migration, and invasion of
gemcitabine (GEM) resistant lung cancer A549 cells (A549/GEM),
and the potential mechanism. Curcumin and GEM can improve
the sensitivity of A549/GEM to the GEM. Compared with the GEM,
GEM plus curcumin significantly decreased the migration and
invasion of A549/GEM cells. The expression levels of MMP9 ,
Vimentin, and N-cadherin were significantly decreased, while the
E-cadherin expression was increased. In vivo experiments showed
a better therapeutic effect of GEM combined with curcumin than
that of GEM alone, and the combination therapy did not cause
more toxicity to animals. In summary, curcumin reversed GEM
resistance and inhibited the EMT process in A549/GEM cells. GEM,
combined with curcumin, is safe and more effective in the
treatment of non-small cell lung cancer.
Curcumin and Piperine in COVID-19: A Promising Duo
to the Rescue? Biomarkers, New Treatments,
and Vaccines for COVID-19 | October 2021 The
combination of curcumin and piperine is a potential option for
the management of COVID-19 based on several mechanisms including
antiviral, anti-inflammatory, immunomodulatory, antifibrotic,
and antioxidant effects. Here, we describe the probable
mechanism of curcumin-piperine against COVID-19. Administration
of curcumin-piperine combination appears as a potential strategy
to counterbalance the pathophysiological features of COVID-19
including inflammation.
Curcumin for Parkinson's disease Cellular
and Molecular Biology | October 2021 Parkinson's disease (PD)
is one of the most prevalent neurodegenerative disorders
worldwide. Curcumin represents a promising bioactive compound
with high therapeutic potential. Diverse studies in cellular and
animal models have suggested that curcumin could be employed for
the treatment of PD.
Current clinical developments in curcumin-based therapeutics for
cancer and chronic diseases Phytotherapy
Research | October 2021 Curcumin, a natural compound
extracted from the rhizomes of Curcuma longa, has been under
intense scrutiny for its wide medicinal and biological
properties. Curcumin is known to manifest antibacterial,
antiinflammatory, antioxidant, antifungal, antineoplastic,
antifungal, and proapoptotic effects. A plethora of literature
has already established the immense promise of curcuminoids in
the treatment and clinical management of various chronic
diseases like cancer, cardiovascular, metabolic, neurological,
inflammatory, and infectious diseases. To date, more than 230
clinical trials have opened investigations to understand the
pharmacological aspects of curcumin in human systems.
Counteracting Action of Curcumin on High
Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
Frontiers in Oncology | October 2021 Along with direct
anticancer activity, curcumin hinders the onset of
chemoresistance. Among many, high glucose condition is a key
driving factor for chemoresistance. Curcumin obviated the
hyperglycemia-induced modulations like elevated glucose
consumption, lactate production, and extracellular
acidification, and diminished nitric oxide and reactive oxygen
species (ROS) production. Modulated molecular regulators are
suggested to play a crucial role as curcumin pretreatment also
prevented the onset of chemoresistance by high glucose. Curcumin
alleviated the suppression of drug retention and nuclear
condensation along with hindering the high glucose-induced
alterations in transcription factors and signal transducers.
Curcumin inhibited the elevated expression of these enzymes,
transporters, and receptors in cancer cells. Curcumin also
uplifted the SDH expression, which was inhibited in high glucose
condition. Taken together, the findings of the present
investigation first time demonstrate the ability of curcumin
against high glucose-induced chemoresistance, along with its
molecular mechanism. This will have implication in therapeutic
management of malignancies in diabetic conditions.
The effects of curcumin supplementation on muscle damage,
oxidative stress, and inflammatory markers in healthy females
International Journal of Preventive Medicine | October 2021
Given the reports of positive effects attributed to curcumin,
many studies have investigated the antioxidant and
antiinflammatory properties of curcumin. A previous report by
Sahin et al. declared that curcumin administration can decrease
muscle damage by regulating the nuclear factor-kappa B (NF-κB)
in male Wister rats. In addition, the results of another study
that performed on 90 rats with poly cystic ovarian syndrome
(PCOS) showed a significant reduction in C-reactive protein
(CRP) levels in the curcumin-treated rats. In healthy young
adult women, 8 weeks of curcumin supplementation yielded
significant improvements in CRP, LDH, MDA, and VO2 max. In the
present study, we found that 8 weeks of curcumin administration
attenuates MDA in females with moderate activity. In agreement
with these findings, a previous study revealed that curcumin
(1000 mg/day co-administered with piperine 10 mg/day)
supplementation for 8 weeks led to a significant decrease in
serum MDA and increase TAC in subjects with type 2 diabetes
mellitus. Concordantly, 6-week supplementation of 1500 mg/day
curcumin elicited significant improvements in antioxidant status
and a significant decrease in MDA concentrations in patients
with knee osteoarthritis. Curcumin, as an antioxidant agent, can
increase superoxide dismutase level via inhibiting
ROS-generating enzymes. In addition, it can increase serum
activities of antioxidants. Another positive action of curcumin
is related to scavenging properties to decrease oxidative
damage.
Curcumin as a great contributor for the treatment
and mitigation of colorectal cancer
Experimental Gerontology | October 2021 This review mainly
brings out the correlation between the curcumin and its use for
the mitigation of colorectal cancer, the use of curcumin as a
chemotherapeutic agent, chemosensitizer, and in a combination
and synergistic approach. The pharmacokinetics and
pharmacodynamics properties of curcumin and its formulation
approach helps in giving an idea to develop new approaches for
the treatment of colorectal cancer using curcumin.
Curcumin induces apoptosis and autophagy in human
renal carcinoma cells Bioengineered |
October 2021 Curcumin is a traditional Chinese herb that has
been used for the treatment of various diseases. The compound
has been particularly confirmed to have anti-inflammatory,
anti-cancer, anti-virus, and anti-oxidant activities. Curcumin
shows less side effects, hence appropriate as a novel anticancer
drug. Previous studies have shown that curcumin administration
inhibited the growth, formation, invasion, and proliferation of
prostate cancer. Curcumin induces apoptosis of RCC through
AKT/mTOR pathway inhibition, suppresses the TNF-a, IL6 and IL-8
pro-inflammatory cytokines. Further, curcumin down-regulates
Akt/mTOR through upregulation of autophagy and finally, curcumin
inhibits tumor weight and volume in vivo. Use of curcumin to
target AKT/mTOR pathway could be an effective treatment
alternative for renal cell carcinoma.
Curcumin attenuates spatial memory impairment by
anti-oxidative, anti-apoptosis, and anti-inflammatory mechanism
NeuroToxicology | October 2021 Curcumin treatment improves
spatial memory impairment after methamphetamine neurotoxicity.
Curcumin treatment has an antioxidant activity in
methamphetamine neurotoxicity. Curcumin treatment reduced
caspase-3 activation after methamphetamine neurotoxicity.
Curcumin treatment has an anti-inflammatory activity in
methamphetamine neurotoxicity via reducing of TNFα. Curcumin
treatment reduced astrogliosis after methamphetamine
neurotoxicity.
Curcumin supplementation in the treatment of patients with
cancer: a systematic review Brazilian
Journal of Pharmaceutical Sciences | October 2021
Curcumin is a long-used phytochemical with a large
number of biological targets, for which anti-inflammatory,
antioxidant, anti-tumor, immunoregulatory, hepatoprotective,
anti-ischemic, anti-dyspeptic, anti-depressant, and analgesic
effects have been determined (Amalraj et al., 2017). Preclinical
studies have reported curcumin as a potent epigenetic regulator,
acting in the inhibition of deoxyribonucleic acid (DNA), DNA
methyltransferases (DNMTs), regulation of modifications of
histone acetyltransferases (HATs) and deacetylases (HDACs) and
in regulation of micro ribonucleic acids (miRNA) (Boyanapalli et
al., 2015; Remely et al., 2015). Studies conducted in vitro show
that curcumin prevents the degradation of nuclear factor
erythroid 2-related factor 2 (Nrf2), leading to an increase in
antioxidant enzymes such as superoxide dismutase (SOD), catalase
and glutathione peroxidase (GPx). In addition, it balances the
level of these enzymes and recovers reactive oxygen species
(Rezaee et al., 2017; Sahebkar, 2013). It was also shown to have
an anti-inflammatory effect through negative regulation of
several cytokines, such as tumor necrosis factor alpha (TNF-α),
interleukins (IL-1, IL-6, IL-8, IL-12), monocyte chemoattractant
protein-1, cyclooxygenase-2 activity (COX-2), lipoxygenase
enzyme and inducible nitric oxide synthase (iNOS) (Aggarwal et
al., 2007; Gupta et al., 2013). In vitro and in vivo
investigations have also shown that curcumin reduces the
inflammatory process by means of inflammatory transcription
factors such as nuclear factor kappa (NF-kB), activator
protein-1 (AP-1) and signal transducer and activator of
transcription 3 (STAT3) (Panda et al., 2017; Imran et al.,
2016). NF-ĸB and AP-1 also act as transcription factors that
regulate the expression of different genes which affect cellular
processes, such as proliferation and apoptosis. Curcumin also
inhibited the expression of urokinase plasminogen (uPA), focal
adhesion kinase activity (FAK), suppressed expression of matrix
metalloproteinases (MMPs), inhibited epidermal growth factor
receptor (EGFR) activity, regulating tumor cell invasion and
metastasis (Durgaprasad et al., 2005; Vadhan-Raj et al., 2007;
Kim et al., 2011; Belcaro et al., 2010; Shokes et al., 2005;
Adhvaryu et al., 2008; Biswas et al., 2010). Due to these
therapeutic properties, curcumin exhibited activities against
various types of cancer (Gupta et al., 2013; Dhillon et al.,
2008; Golombick et al., 2009; Ide et al., 2010). The
results of this study are based on those obtained in the
literature on the effect of curcumin on the anti-inflammatory
profile, on reducing dermatitis, on PSA alteration and on
anti-oxidant profile for a total of 450 individuals, comprising
259 in the intervention group and 191 in the control group. Some
studies have reported improvement in biochemical and clinical
indicators, with limited adverse effects and good tolerance.
The clinical use of curcumin on neurological
disorders: An updated systematic review of clinical trials
Phytotherapy Research | October 2021 Neuroprotective effects
of curcumin have been shown in previous studies. This updated
systematic review of clinical trials aimed to investigate the
effect of curcumin on neurological disorders. Databases
including PubMed, Scopus, Web of Science, and Google Scholar
were systematically searched to identify clinical trials
investigating the effects of curcumin/turmeric supplements
alone, or in combination with other ingredients, on neurological
diseases. Nineteen studies comprising 1,130 patients met the
inclusion criteria. Generally, intervention and study outcomes
were heterogeneous. In most of the studies, curcumin had a
favorable effect on oxidative stress and inflammation. However,
with the exception of AD, curcumin supplementation either alone,
or in combination with other ingredients, had beneficial effects
on clinical outcomes for the other aforementioned
neurodegenerative diseases. For example, the frequency,
severity, and duration of migraine attacks, scores on the
revised ALS functional rating scale, and the occurrence of motor
complications in PD were all significantly improved with
curcumin supplementation either alone or in combination with
other ingredients.
Curcumin exhibited better potential inhibition than
Hydroxy-Chloroquine against COVID-19
Biological and Medicinal Chemistry | October 2021 According
to present research results, Quercetin, Hispidulin,
Cirsimaritin, Sulfasalazine, Artemisin and Curcumin exhibited
better potential inhibition than Hydroxy-Chloroquine against
COVID-19 main protease active site and ACE2.
Targeting of cancer cell death mechanisms by
curcumin: Implications to cancer therapy
Basic & Clinical Pharmacology & Toxicology | October 2021
Curcumin (which originates from turmeric) is a hydrophobic
polyphenol. It is one of the most famous anticancer and
anti-inflammatory herbal agents. Traditionally, curcumin was
used for some diseases such as acne and some
inflammation-related diseases like arthritis. Today, we
know that curcumin has antioxidant and anti-inflammatory
effects, which cause beneficial effects on the cardiac and
neural systems and also has pharmacological effects on some
diseases such as diabetes, Alzheimer, atherosclerosis, some
immune system diseases and cancer. Curcumin has shown anticancer
properties for several types of malignancies in both in vitro
and in vivo studies. Gastrointestinal system malignancies, lung
cancer, brain cancer cells, leukaemia, melanoma and renal,
breast, prostate and pancreas cancers are some examples of
inhibition of cancers by curcumin. Curcumin has also been shown
to amplify the anticancer effects of chemotherapy drugs and
radiotherapy. Although several agents may increase the
therapeutic response of cancer cells to therapy, curcumin has
shown interesting results for the protection of normal
cells/tissues, a property that can reduce side effects of cancer
therapy. Curcumin has been shown to protect several organs such
as the lung, gastrointestinal system, heart, liver, testis, bone
marrow and skin against the toxic effects of radiotherapy and
chemotherapy. Curcumin as a natural agent has shown interesting
anticancer properties. It can prevent genomic instability in
normal cells to prevent the development of cancer. Furthermore,
it can suppress tumour growth at different stages through
induction of cell death, suppression of cancer cells' migration,
angiogenesis, and others. In this review, we focused on the
mechanisms of cell death induction in tumours using curcumin.
Curcumin is one of the most common herbal agents that has shown
several anticancer properties. It can regulate immune system
responses against cancer. Furthermore, curcumin has been shown
to potentiate cell death signalling pathways and attenuate
survival signalling pathways in cancer cells. The knowledge of
how curcumin induces cell death in cancers can improve
therapeutic efficiency. In this review, the regulatory effects
of curcumin on different cell death mechanisms and their
signalling pathways will be discussed. Furthermore, we explain
how curcumin may potentiate the anticancer effects of other
drugs or radiotherapy through modulation of apoptosis, mitotic
catastrophe, senescence, autophagy and ferroptosis.
The Functional Roles of Curcumin on Astrocytes in
Neurodegenerative Diseases
Neuroimmunomodulation | October 2021 Curcumin is the main
component of a yellow pigment, commonly called
diferuloylmethane, and is an active ingredient in the rhizome of
the herb Curcuma longa that represents various biomedical
applications. Curcumin has also been traditionally used for its
medicinal benefits and wound healing for centuries. It was first
applied as a drug to treat biliary disease in 1937. Curcumin is
a lipophilic polyphenol that is relatively stable in the acidic
pH but decomposes in neutral-basic conditions. Curcumin contains
approximately 77% diferuloylmethane, 17% dimethoxycurcumin, and
6% bisdemethoxycurcumin. Nowadays, curcumin (C21H20O6) has
important roles in the attenuation of progression of some
neurodegenerative diseases because of its anti-amyloid and
anti-inflammatory agents. In addition, curcumin also has several
benefits, such as being safe, inexpensive, and readily available
polyphenol that can cross the blood-brain barrier, thus
attracting researchers to use it for treating neurodegenerative
diseases. Curcumin is an NF-κB inhibitor by interrupting ZO-1
expression and localization, MLC phosphorylation, and ROS
generation inhibition, which constrains disruption of the
blood-brain barrierby Th17 cells. Furthermore, curcumin, through
its NF-κB inhibitory effect, causes intestine dendritic cell
differentiation into tolerogenic phenotypes, as well as naive T
cells to differentiate into FoxP3+ regulatory T cells (intestine
protective, Treg). Thus, curcumin can prevent colitis, due to
its anti-inflammatory function. The pharmacological
activities of curcumin are antimicrobial, anti-inflammatory,
antioxidant, and anticarcinogenic. It also exhibits potent
immunoregulatory activities that can modulate the T cells, B
cells, neutrophils, natural killer cells, and macrophage
activation and function. Curcumin has been shown to be
protective for several cells, including astrocytes, neurons,
microglia, and different part of the CNS such as hippocampal,
mesencephalic, cortical, and spinal cord. An MS animal study
showed that curcumin regulates T-cell responses to IL-12 by
blocking IL-12 production, and IL-12 signaling, through
inhibiting JAK-STAT signaling activation. Thus, it has been
suggested that curcumin could be used for treating MS and other
Th1-cell-mediated inflammatory diseases. Furthermore, curcumin
at high doses can directly induce T-cell apoptosis and inhibit
T-cell proliferation through blocking of the IL-2 signaling
pathway, high-affinity IL-2R, and interfering with IL-2R
signaling. These data indicate that curcumin has
immunosuppressive effects on many pathways. Thus, curcumin,
through its proinflammatory cytokines, decreases TNF-α/β, IL-1,
IL-6, and IL-8, and COX-2 provides a therapeutic effect by
reducing inflammatory conditions. Curcumin can cross blood-brain
barrier and, by inhibiting proinflammatory cytokines, can
regulate homeostasis of the CNS. The blood-brain barrier has a
crucial role in controlling the homeostasis of the brain
microenvironment. Thus, because autoreactive T-cell penetration
plays a key role in MS lesion development, the role of curcumin
to protect the blood-brain barrier could reduce the severity of
MS. Curcumin also decreases the severity of chronic inflammatory
diseases, such as rheumatoid arthritis, asthma, AD, and cancer.
In phase II clinical trial, curcumin was used orally in a mouse
model of colorectal cancer. It has been demonstrated that
curcumin can prevent carcinogenesis through different mechanisms
such as reduction of cyclooxygenases 1 and 2, 5-lipoxygenase,
prostaglandin E2 (PGE2), and 5-hydroxyeicosatetraenoic acid
production inhibition. Fortunately, curcumin via inhibition of
NF-κB signaling pathways can improve the effects of some
chemotherapy drugs. For example, in the mouse model of human
breast cancer, curcumin, in conjunction with paclitaxel, can
slow breast cancer progression and metastasis to the lung.
Unfortunately, curcumin has several disadvantages in cancer
treatment, including inhibition of some chemotherapy drug
activities. For example, curcumin decreased camptothecin-induced
death in cultured breast cancer cells and inhibited breast tumor
regression in mice. Furthermore, curcumin can also interfere
with colon cancer treatment through the change in irinotecan
absorption and efficacy. Curcumin is a valuable ingredient
present in turmeric spice and has several essential roles,
including those which are anticarcinogenic, hepatoprotective,
thrombosuppressive, cardioprotective, anti-arthritic,
anti-inflammatory, antioxidant, chemopreventive,
chemotherapeutic, and anti-infectious. Furthermore, curcumin can
suppress inflammation; promote angiogenesis; and treat diabetes,
pulmonary problems, and neurological dysfunction.
Pharmacological properties and underlying mechanisms of curcumin
and prospects in medicinal potential
Biomedicine & Pharmacotherapy | October 2021 The chemical
structure of curcumin known as diferuloylmethane has been
elucidated in 1910, the first study on its biological activity
as an antibacterial agent according to the PubMed database has
been published in 1949 Nature journal and the first clinical
trial has been reported in 1937 Lancet journal. Until now, there
are numerous in vitro, in vivo, and clinical studies that show
it contained antioxidant, anti-inflammatory, anti-cancer,
anti-diabetic, and anti-viral infection. The major constituents
of curcuminoids contain Dihydrocurcumin, Tetrahydrocurcumin,
Curcumin, Bis-demethoxycurcumin, and Demethoxycurcumin from
turmeric (C. longa L.) rhizome. The beneficial health properties
and medicinal values of curcumin include its effect on immune
modulation, cardiovascular protection, and neuroprotection.
Previous report, the potential of turmeric as an antimicrobial,
insecticidal, larvicidal, antimutagenic, radioprotector, and
anticancer agent have validated in cell-based studies. Numerous
animal studies have found the latent of turmeric against
proinflammatory diseases, obesity, diabetes, atherosclerosis,
cancer, depression, and neurodegenerative diseases. Moreover,
turmeric has shown efficacy against numerous human disorders
including lupus nephritis, irritable bowel syndrome, acne,
fibrosis, diabetes, and cancer in clinical trial. Of note,
curcumin, major component of turmeric, is widely studied at the
preclinical level in various chronic illnesses that have been
extensively reviewed in many papers including mechanistic
insights . Of note curcumin is an important active ingredient in
turmeric that exerts pharmacological effects. Current research
has demonstrated that the pharmacological effects of curcumin
include: anti-lipidemics, anti-diabetics, anti-tumor,
anti-inflammatory, anti-fibrosis, anti-virus, anti-oxidation,
and serve as free radical scavengers.
Curcumin suppresses the progression of gastric
cancer Open Life Sciences | October 2021
Curcumin is a natural polyphenolic compound isolated from
turmeric, which has lipid-lowering, anti-tumor,
anti-inflammation, and anti-oxidation effects. Recently, studies
have shown that curcumin can reduce the malignancy of several
cancers, such as pancreatic cancer, retinoblastoma,
osteosarcoma, and bladder cancer. Moreover, curcumin has also
been reported to have an anti-tumor effect on gastric cancer.
Nonetheless, the role and underlying mechanism of curcumin in
gastric cancer have not been well recognized. We
discovered that curcumin was able to inhibit gastric cancer cell
growth and motility and induce apoptosis by suppressing
circ_0056618 and elevating miR-194-5p. Previous research have
verified that curcumin exerts the anti-tumor effect mainly by
repressing tumor cell proliferation and motility and
facilitating apoptosis. For example, curcumin treatment
restrained Rb cell proliferation, invasion, and migration and
accelerated apoptosis. Curcumin suppressed the growth and cell
cycle process and facilitated the apoptosis of gastric cancer
cells. In line with these reports, we demonstrated that curcumin
treatment restrained cell colony formation, migration, and
invasion and accelerated cell cycle arrest and apoptosis in
gastric cancer cells in vitro and blocked tumorigenesis of
gastric cancer in vivo, indicating that curcumin might be a
candidate agent for gastric cancer therapy. In summary,
curcumin treatment could repress gastric cancer cell growth and
metastasis and promote apoptosis partly by regulation of
circ_0056618/miR-194-5p axis. The findings facilitated our
understanding on the mechanism of curcumin in gastric cancer
therapy and indicated that curcumin might be a potential
therapeutic drug for gastric cancer . In addition, accumulating
evidence showed that curcumin might prevent gastric cancer
through regulation of oncogenic pathways.
The Therapeutic Effects of Curcumin in Early Septic
Acute Kidney Injury: An Experimental Study
Drug Design, Development and Therapy | October 2021 Curcumin,
the major active component of Curcuma longa, was first isolated
in 1870 and widely used as spice, flavor, and colorant in daily
life.12 Several studies have evidenced the antioxidant,
anti-inflammatory, anticarcinogenic, cardioprotective and
nephroprotective effects of curcumin. The protective effects of
curcumin on AKI are generally associated with its bifunctional
antioxidant activity and anti-inflammatory activity Curcumin
could ameliorate kidney disease with either acute or chronic
nephritis, and reduce activation of the NF-κB, MAPK, AKT and
pBAD pathways either systemically, or within the inflamed
kidneys. In addition, previous research found that curcumin
could improve renal function during ischemia-reperfusion induced
acute kidney injury, which protected the tubular epithelium from
injury by modulating inflammatory processes, oxidative stress,
and apoptosis. In our study, we show that curcumin represents a
new and promising effective treatment in S-AKI rat models.
Treatment with curcumin ameliorates renal functions, improves
both renal macro- and microcirculatory flow, reduces
inflammatory response and prevents pathological changes in
kidney. Curcumin may be a potential novel therapeutic
agent for the prevention or reduction of S-AKI.
Curcumin Reduces Adipose Tissue Inflammation and
Alters Gut Microbiota in Diet-Induced Obese Male Mice
Molecuar Nutrtion and Food Research | October 2021 Curcumin
exerts protective metabolic effects in dietary obesity, in part
through downregulation of adipose tissue inflammation, which may
be mediated by alterations in composition of gut microbiota, and
metabolism of curcumin into curcumin-o- glucuronide.
New insights of structural activity relationship of curcumin
and correlating their efficacy in anticancer studies
American Journal of Cancer Research | October 2021 During the
process of carcinogenesis at multiple stages, curcumin is
involved in several mechanisms including (a) the inhibition of
tumor initiation (cytotoxic studies) (b) suppression of cellular
proliferation (antiproliferation studies) (c) the induction of
apoptosis (d) the inhibition of angionesis and metastasis (e)
the inhibition of tumor induced immunosuppression. Analyzing the
cytotoxic results, curcumin has shown its potency towards most
of the cancer cell lines like Hela (Cervical cancer), HepG2
(Liver cancer), A549 (Adenocarcinoma human alveolar), MCF-7 and
MDA-MB-231 (Breast cancer), PC-3, RWEP-1 and DU145 (Prostate
cancer), SkoV3 (Ovarian cancer), A-431 (Epidermoid carcinoma),
U-251, T98, U87, U87 MG and U87 GBM (Glioblastoma), Panc-1 and
BxPC3 (Pancreatic cancer), HT-29 and HCT116 (Colon cancer),
H1299 and H460 (Lung cancer), AGS (Gastric cancer), HCT-15
(Colorectal adenocarcinoma), K562 (Chronic myelogenous).
Demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are
naturally occurring compounds, which shows enhance potency
against cancer cell lines in vitro and differ from
curcumin in the position and number of hydroxyl and methoxy
substitution pattern. The presence of methoxy and hydroxyl group
in curcumin plays a vital role in deciding various biological
activities as reported by various research groups. Curcumin is a
naturally occurring compound which appears to be significant
clinical for applications in vitro as well as in vivo studies.
Many of the research groups have been paying attention towards
natural products for the development of anticancer drugs.
Curcumin, Rosmarinic acid and Chalcone are the naturally
occurring compounds, which are chemopreventive and
chemotherapeutic.
The effects of curcumin as dietary supplement for
patients with polycystic ovary syndrome
Phytotherapy Research | October 2021 Compared with the
control group, curcumin was associated with a statistically
significant improvement in the glycemic control including
fasting blood glucose, insulin level, homeostasis model
assessment of insulin resistance, and quantitative insulin
sensitivity check index. The mean difference in total
cholesterol was also statistically significant. This review
concluded that among patients with PCOS, the use of curcumin
demonstrated a significant difference from the control group for
glycemic control. Those findings suggest that curcumin confers
clinical benefits in patients with PCOS.
Curcumin as an Adjuvant to Cancer Immunotherapy
Frontiers in Oncology | September 2021 Turmeric, a
common spice obtained from Curcuma longa of the Zingiberacea
(Ginger) plant family, is the natural source of curcuminoids, a
mixture of three different components, i.e., curcumin,
demethoxycurcumin, and bisdemethoxycurcumin. A major fraction of
this compound mixture is curcumin or diferuloylmethane with
368.38 molecular weight. The crystalline orange-yellow powder is
an active polyphenolic phytochemical and has been widely used in
medicinal purposes for centuries in India and South Asia, due to
its nontoxic but miraculous properties such as anti-oxidant,
analgesic, antiseptic, anti-inflammatory, and anti-cancer
activity. Over time, curcumin has been considered as a
potential anti-cancer molecule. Its potentialities have been
recorded against the standard hallmarks of cancer such as
continuous proliferation, escaping apoptosis, continuous
angiogenesis, insensitivity to growth inhibitors, tissue
invasion, and metastasis. Finally, the conclusion has been
drawn with the application of curcumin as a potential
immune-adjuvant, which fearlessly could be used with
immunotherapies for best outcomes. Hence, it is considered very
interesting to envision the role of curcumin concerning cancer
immunotherapies as an immunomodulator.
Curcumin improves memory deficits by inhibiting
HMGB1-RAGE/TLR4-NF-κB signalling pathway
Journal of Cellular and Molecular Medicine | September 2021
Curcumin, extracted from turmeric rhizomes, is a Food and Drug
Administration-approved food additive in the curry spice
turmeric. It possesses potent anti-inflammatory and antioxidant
properties and is widely used to treat chronic inflammatory
diseases, such as heart disease, cancer, metabolic syndrome and
various other degenerative diseases.It has therapeutic potential
in AD models, both in vitro and in vivo. Curcumin is a natural
polyphenolic product derived from the rhizome of Curcuma longa
and has various beneficial properties, such as
anti-inflammatory, antioxidant and antitumor properties. Here,
we found that curcumin treatment effectively improved the
cognitive performance of transgenic mice in the MWM and Y-maze,
and our results were consistent with those of previous studies.
In conclusion, this study demonstrated that curcumin treatment
significantly ameliorates cognitive impairment in aged APP/PS1
transgenic mice. The possible underlying mechanism might be
associated with the accumulation of amyloid plaques, activation
of the HMGB1-RAGE/TLR4-NF-κB signalling pathway, and astrocytes
activated during neuroinflammation in APP/PS1 transgenic mice.
These results suggest that curcumin treatment, as a food
additive for long-term oral administration, is an effective
therapeutic strategy for AD.
Antimetastatic Effects of Curcumin in Oral and Gastrointestinal
Cancers Frontiers in Pharmacology |
September 2021 For centuries, curcumin has been widely used
as a dietary spice, and contemporary research studies have
confirmed its efficacy in cancer therapy. Anticancer effects are
the most pivotal properties of curcumin, which affect the
different stages of cancer progression, including cancer cell
formation, proliferation, and tumor invasion. According to
extensive research, curcumin can suppress metastasis in GI
cancers via regulating various signaling pathways. Curcumin has
a crucial function in metastasis prevention by several
mechanisms, including preventing transcription factors as well
as their signaling pathways (e.g., NF-κB, STAT3, AP-1), multiple
proteases (e.g., MMPs, uPA), inflammatory cytokines (e.g.,
CXCL1, IL-6, CXCL2, IL-8), modulation of miRNAs (e.g., miR181b,
miR21), multiple protein kinases (e.g., FAK, MAPKs), and heat
shock proteins (HLJ1). According to research, curcumin treatment
leads to significant elevation in metastatic tumor
cross-sectional volume (70%) and zone (46%). Curcumin may
enhance LLC's metastatic growth in mice by elevating the
concentration of VEGF, angiogenic factors, monocyte chemotactic
protein-1 (MCP-1), and IL-1β. In addition to the possible
pharmaceutical effects of curcumin, the safety and relevant
therapeutic dose should also be established, given reports on
the side effects of curcumin in cancer therapy. Curcumin a
polyphenolic extraction of Curcuma longa species, which is often
termed as turmeric (Shafabakhsh et al., 2019; Ashrafizadeh et
al., 2020). Curcumin had been used as a traditional Ayurvedic
medicine due to its significant anti-inflammatory (Satoskar et
al., 1986), antioxidant (Masuda et al., 2001), and antimicrobial
(Negi et al., 1999) properties. Currently, curcumin is
associated with powerful anticancer properties. Different animal
studies have shown that curcumin has important roles in
inhibiting primary tumorigenesis in numerous organs as
metastatic sites, such as mammary glands (Inano et al., 1999)
and gastrointestinal tract (Huang et al., 1994).It also diminished the vascular endothelial growth factor
(VEGF) serum levels in mice models of hepatocellular carcinoma
(Yoysungnoen et al., 2006).
Curcumin suppresses inflammatory signaling in brain
microglia The Journal of Immunology |
September 2021 Curcumin is a major component of tumeric. It
has been used as an Indian medicine for centuries, and is
currently commonly used as a spice for flavor and to impart a
yellow color. Curcumin has recently received much attention for
its anti-inflammatory, antioxidant, and antitumor activities.
The anti-inflammatory actions of curcumin seem to be closely
related to the suppression of proinflammatory cytokines and
mediators of their release such as TNF-γ, IL-1β, and NOs. There
are reports that curcumin inhibits cytokine-mediated NF-κB
activation by blocking a signal leading to I-κB kinase activity
in intestinal epithelial and mouse fibroblast cells, and also
suppresses phorbol ester-induced c-Jun/AP-1 activation. However,
the mechanisms underlying interactions of curcumin with these
signaling pathways are poorly understood. Recently, we have
shown that JAK-STAT inflammatory signaling modulates glial
activation. Thus, we examined whether curcumin inhibits the
JAK-STAT pathways in activated microglia. Curcumin inhibits the
phosphorylation of JAK1 and JAK2 via the increased
phosphorylation of SHP-2 and its association with JAK1/2, thus
attenuating inflammatory response. Our results show that
curcumin acts via a novel anti-inflammatory mechanism and is
also a negative regulator of the JAK-STAT pathway by the
activation of SHP-2. Taken together, these data suggest curcumin
suppresses JAK-STAT signaling via activation of SHP-2, thus
attenuating inflammatory response of brain microglial cells.
Curcumin as Prospective Anti-Aging Natural Compound:
Focus on Brain
Molecules | September 2021 Curcumin is a natural dietary
polyphenol extracted from Curcuma longa Linn with
different biological and pharmacological properties including
antioxidant, immunomodulatory, anti-inflammatory,
anti-microbial, cardio-protective, nephro-protective,
hepato-protective, anti-neoplastic, anti-rheumatic, and
anti-aging. The chemical name of curcumin is
1,7-bis(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione
with a chemical formula of C12H20O6; it is formed by two
aromatic rings with a methaxy phenolic group, kinked with a
linear carbon chain, with an α,β-unsatured β-diketone moiety.
Curcumin, like other polyphenols, has pleiotropic activity.
Indeed, due to its capacity to interact with many proteins,
curcumin can induce cellular response to external stimuli.
Moreover, curcumin up- and downregulates different miRNA and
takes part in epigenetic changes in cell. In our view,
curcumin is one of the best candidates to achieve this goal with
its antiviral, antinociceptive, anti-inflammatory, antipyretic,
and antifatigue proprieties. It is important to highlight that
Curcumin is devoid of any significant toxicity in most of the
preclinical as well as clinical investigations, and few
investigations have reported negative effects of curcumin. In
addition, natural products may be a safe, secure, and dependable
source to find drugs responsible for controlling the current
pandemic, and even if the beneficial effects of curcumin against
SARS-CoV-2 have not yet been reported, curcumin has some useful
clinical effects that could be effective to manage the symptoms
of the infected patient with COVID-19. Curcumin in fact can
modulate the events of SARS-CoV-2 cellular entry, their
replication, and molecular cascade manifesting
pathophysiological consequences of COVID-19. Due to its
important and healthy proprieties, we think that dietary
supplementation with curcumin could be a suitable approach to
prevent a large panel of diseases and improve the quality of
life. In this review, we have described the anti-aging potential
of curcumin with particular regard to prevention and treatment
of brain diseases, in different ways: (1) by acting on different
target proteins, (2) by inducing antioxidant and
anti-inflammatory events, (3) by modulating microglia
neuroprotection, and (4) by acting on telomerases to arrest
cancer progression.
Curcumin Reduces Colorectal Cancer Cell Proliferation and
Migration and Slows In Vivo Growth of Liver Metastases in Rats
Biomedicines | September 2021 Curcumin has shown an
anti-tumor effect against liver implants from colorectal cancer,
both in vitro and in vivo, in this experimental model. Curcumin
is a well-known plant-derived polyphenol with a wide range of
activities, such as antibacterial, anti-inflammatory, and
hepatoprotective properties. In vitro studies with several
cancer cell lines have proven curcumin to inhibit proliferation,
such as on MCF-7 human breast tumor cells. It has also been
observed that curcumin can improve the efficacy of other
therapies, such as Paclitaxel on rat glioma C6 cells, and of
5-FU and/or oxaliplatin in BGC-823 human gastric cancer cell
line or in HCT116 human colon cancer cells. In this cell line,
it has been found that curcumin inhibits the cell cycle,
activates p53 (only in p53+/+ cells) and p21, and triggers
cellular senescence (irreversible growth arrest of proliferating
cells) through the activation of the lysosomal enzyme
senescence-associated-β-galactosidase (SA-β-gal) and the
upregulation of the p21 protein. Other studies have also shown
that curcumin-induced apoptosis is related to oxidative stress
caused by the production of superoxide anion, which contributes
to p53-independent cellular cytotoxicity. These findings were
further corroborated in other cell lines (COLO-205), showing
that curcumin induces cytotoxicity and apoptosis in a
dose-dependent manner. In addition, curcumin promotes the
production of reactive oxygen species and Ca2+, and induces the
caspase-3 activity. In in vivo animal studies using cancer cells
implants (most of them in animals lacking immune system),
curcumin reduces the growth of the implants and the appearance
of metastases. It has also been demonstrated that curcumin
reduces tumor invasion and metastatic growth by, for example,
reducing the activity of matrix metalloproteinases (MMPs) 2 and
9, or blocking nuclear translocation of nuclear factor kappa B
(NFκB) by inhibiting the inhibitor of kappaB kinase. This
molecular pathway is also involved in the prevention of liver
damage after exposure to radiotherapy by regulating oxidative
stress damage and reducing the accumulation of reactive oxygen
species, which are well known to contribute to tumor progression
by promoting cell transformation, proliferation, and the
survival of tumor cells.
Behavioral and morphological effects of resveratrol
and curcumin in rats submitted to doxorubicin-induced cognitive
impairment Research in Veterinary Science |
September 2021 Curcumin prevented short and long-term memory
deficits caused by doxorubicin.
The Influence of Turmeric and Curcumin on Female
Reproductive Processes Planta Medica |
September 2021 The present review summarizes the available
knowledge concerning the action of curcumin, the best-known
polyphenol among the rhizomes of Curcumas, on female
reproductive processes and their dysfunctions. Curcumin affects
a number of physiological processes, including female
reproduction (puberty, reproductive aging, ovarian
follicullogenesis and oogenesis, and fecundity). Curcumin can
affect these processes via changes in the release and reception
of pituitary and ovarian hormones, growth factors and cytokines.
Furthermore, it can influence the response of ovarian cells to
these substances and external environmental factors. Finally,
curcumin can affect oxidative processes within the ovary and
numerous intracellular signalling pathways related to ovarian
cell proliferation and apoptosis. These effects suggest the
applicability of curcumin for stimulation of female reproductive
processes in vivo and in vitro, as well as for the prevention,
mitigation, and treatment of various reproductive disorders from
ovarian insufficiency and infertility to polycystic ovarian
syndrome and ovarian cancer.
Curcumin Inhibits Replication of Human Parainfluenza
Virus BioMed Research International |
September 2021 Curcumin is a natural phenolic compound
extracted from a plant turmeric rhizome. It has a wide range of
anti-inflammatory, antioxidant, and antitumor properties. Recent
studies have found that curcumin has broad-spectrum antiviral
capabilities. Here, we identify a novel role for curcumin as an
antiviral drug against HPIV3 infection through its ability to
affect IB formation and viral replication. This provides a
theoretical basis for research and development of HPIV3
antiviral drugs, with implications for parainfluenza virus
research and other similar viruses. Our studies found that
curcumin has a significant antiviral effect on HPIV3 infection
and has varying degrees of impact on multiple stages of the
viral life cycle. Curcumin can disrupt the structural integrity
of F-actin, downregulate the endogenous PI4KB expression, and
interfere with the colocalization of PI4KB and IBs, thereby
hindering viral IB formation and inhibiting viral replication.
Mazumder discovered that curcumin could inhibit HIV-1 integrase,
thereby inhibiting HIV-1 infection, and inhibit HCV replication
by interfering with the Akt-SREBP-1 pathway. Curcumin can also
interfere with binding of Zika and Chikungunya viruses to host
cells to inhibit viral infection. To inhibit hepatitis B virus,
curcumin can downregulate the metabolic molecule PGC-1. Although
curcumin pretreatment does not affect plaque formation of
enterovirus 71 (EV71), curcumin downregulates PI4KB expression
in cells and affects the in vitro replication of EV71. Several
studies have shown that curcumin has antiviral ability against
enveloped and nonenveloped viruses, and the antiviral mechanisms
in different viruses are also diverse.
Turmeric and Curcumin: From Traditional to Modern Medicine
Studies on Biomarkers and New Targets in Aging
Research | September 2021 The rhizome of turmeric (Curcuma longa
L.) has been used as an herbal medicine, coloring agent, spice,
and food additive for thousands of years in different parts of
the world particularly in Asian countries. It has been used for
a range of diseases in many traditional medical schools,
including Islamic traditional medicine, Chinese traditional
medicine, and Ayurveda. It has been used mainly for digestive
problems, as a cardio-, hepato-, and neuroprotective agent as
well as in many inflammatory conditions such as arthritis and
for enhancing immune system. Curcumin, a diarylheptanoid
derivative found in turmeric, has anti-inflammatory,
antioxidant, and anticancer properties; controls obesity and
metabolic problems; and improves memory and mood disorders.
These findings emphasize that most of the
traditional applications of turmeric is due to the presence of
its key constituent, curcumin. According to the traditional
background of turmeric use and clinical values of curcumin,
further preclinical studies for unstudied properties and
clinical studies with larger sample sizes for confirmed
activities are expected.
Efficacy and Safety of Curcumin Supplement on
Improvement of Insulin Resistance in People
with Type 2 Diabetes Mellitus Evidence-Based Complementary
and Alternative Medicine | September 2021 Curcumin is a
chemical component extracted from the rhizome of some plants. It
has a series of effects such as blood lipid lowering, antitumor,
anti-inflammatory, and antioxidation and has been used as a food
flavoring agent, preservative, and ancillary medication for some
diseases (such as heart disease and tumors). In the treatment of
diabetes, there is also evidence to support curcumin as a part
of the diabetes treatment program. Based on the current
evidence, curcumin may assist in improving insulin resistance,
glycemic control, and decrease in TG and TC in patients with
T2DM.
Curcumin functions as an anti-inflammatory and
antioxidant agent on arsenic-induced hepatic and kidney injury
Environmental Toxicology | September 2021 As a plant
polyphenol, curcumin is the most vital bioactive ingredient of
turmeric and has a wide range of pharmacological activities. In
the present study, we investigated the potential roles of
curcumin against arsenic-induced liver and kidney dysfunctions
in mice. Curcumin treatment (200 mg/kg) not only decreased the
deposition of arsenic in liver and kidney, but also relieved the
hepatic and nephritic biochemical indexes (Glutamic oxaloacetic
transaminase [AST], Alanine aminotransferase [ALT], albumin, and
creatinine) altered by arsenic at doses of 10 and 25 mg/L via
drinking water. What's more, curcumin exerted influences on the
activities of myeloperoxidase and on the secretion of
inflammatory cytokines in liver and kidney tissues. In addition,
the levels of mitogen-activated protein kinases (MAPKs) and
nuclear factor kappa B (NF-κB) phosphorylation were declining
while NRF2-signaling targets were increasing in mice liver and
kidney by curcumin administration. In conclusion, our results
here suggest that curcumin could exert both anti-inflammatory
and antioxidant functions on arsenic-induced hepatic and kidney
injury by inhibiting MAPKs/NF-κB and activating Nrf2 pathways
cooperatively.
Anti-Inflammatory Effect of Curcumin on the Mouse
Model of Myocardial Infarction Mediators of
Inflammation | September 2021 Curcumin, an active ingredient
extracted from natural plants, has been proven to have many
physiological effects, including hypolipidemic, antitumor,
anti-inflammatory, and antioxidation, and was used as treatment
for drug-resistant tuberculosis, etc. Importantly, previous
studies have shown that curcumin promotes heart repair after
myocardial infarction and improves cardiac dysfunction, as well
as improving the therapeutic efficacy of heart failure after
myocardial infarction, but the specific mechanism is imperfect.
In addition, curcumin has been found to suppress inflammation by
inhibiting macrophage infiltration, and it can also regulate
macrophage polarization. In this study, we found that curcumin
not only attenuated ventricular remodeling and inflammation
after MI but also reduced M1 but increased M2 macrophage
activation in the MI mouse model. In addition, in vitro studies
also revealed that some curcumin regulates the molecular
mechanism of macrophage polarization, which was regulated AMPK
expression. All in all, our research enriches the mechanism of
curcumin in the treatment of myocardial infarction.
Effects of Curcumin against Influenza Using In Silico and In
Vitro Approaches Pharmaceuticals |
September 2021 Curcumin has attracted considerable research
interest because of its versatile pharmacological properties,
including anti-inflammatory, antiviral, and anticancer effects.
Previous studies have reported that curcumin inhibits the
influenza virus by interfering with cellular signaling pathways,
including Toll-like receptor and nuclear factor-κB pathways, and
disrupting the viral envelope and liposomal membranes.
Curcumin: Implications for the Treatment of Multiple
Sclerosis Studies on Biomarkers and New
Targets in Aging Research | September 2021 Curcumin is the
active component of turmeric and a phenolic phytochemical. This
phytochemical has anti-inflammatory properties and has been
shown by multiple studies to downregulate NF-κB and its
downstream gene targets including cyclooxygenase-2, tumor
necrosis factor-α, interleukin-1, and interleukin-6.
Antimetastatic Effects of Curcumin in Oral and Gastrointestinal
Cancers Frontiers in Pharmacology | August
2021 For centuries, curcumin has been widely used as a
dietary spice, and contemporary research studies have confirmed
its efficacy in cancer therapy. Anticancer effects are the most
pivotal properties of curcumin, which affect the different
stages of cancer progression, including cancer cell formation,
proliferation, and tumor invasion. According to extensive
research, curcumin can suppress metastasis in GI cancers via
regulating various signaling pathways. Curcumin has a crucial
function in metastasis prevention by several mechanisms,
including preventing transcription factors as well as their
signaling pathways (e.g., NF-κB, STAT3, AP-1), multiple
proteases (e.g., MMPs, uPA), inflammatory cytokines (e.g.,
CXCL1, IL-6, CXCL2, IL-8), modulation of miRNAs (e.g., miR181b,
miR21), multiple protein kinases (e.g., FAK, MAPKs), and heat
shock proteins (HLJ1). According to research, curcumin treatment
leads to significant elevation in metastatic tumor
cross-sectional volume (70%) and zone (46%). Curcumin may
enhance LLC's metastatic growth in mice by elevating the
concentration of VEGF, angiogenic factors, monocyte chemotactic
protein-1 (MCP-1), and IL-1β.Curcumin or
[(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione]
is a polyphenolic extraction of Curcuma longa species. Curcumin
had been used as a traditional Ayurvedic medicine due to its
significant anti-inflammatory (Satoskar et al., 1986),
antioxidant (Masuda et al., 2001), and antimicrobial (Negi et
al., 1999) properties. Currently, curcumin is associated with
powerful anticancer properties. Different animal studies have
shown that curcumin has important roles in inhibiting primary
tumorigenesis in numerous organs as metastatic sites, such as
mammary glands (Inano et al., 1999) and gastrointestinal tract
(Huang et al., 1994). It also diminished the
vascular endothelial growth factor (VEGF) serum levels in mice
models of hepatocellular carcinoma (Yoysungnoen et al., 2006).
Interleukin (IL)-1β and monocyte chemotactic protein-1 (MCP-1)
are critical inflammatory cytokines in tumorigenesis.
Accordingly, some studies demonstrated that these cytokines'
expression levels reduced after curcumin intervention (Abe et
al., 1999). Recent studies have also indicated that curcumin can
modulate tumor immune responses and remodel the tumor
immunosuppressive microenvironment, indicating its potential in
the immunotherapy of cancer (Mukherjee et al., 2018; Bahrami et
al., 2019a; Pan et al., 2019). Curcumin has antimetastatic
activities, modulating T cells, B cells, macrophages,
neutrophils, NK cells, dendritic cells and production of
cytokines and chemokines. In addition, recent studies have shown
that curcumin exerts immunosuppressive effects (Shafabakhsh et
al., 2019). These findings showed that curcumin has crucial
roles in the inhibition of angiogenesis and metastasis in GI
cancers.
Curcumin as Prospective Anti-Aging Natural Compound: Focus on
Brain Molecules | August 2021 Curcumin
is a natural dietary polyphenol extracted from Curcuma longa
Linn with different biological and pharmacological properties
including antioxidant, immunomodulatory, anti-inflammatory,
anti-microbial, cardio-protective, nephro-protective,
hepato-protective, anti-neoplastic, anti-rheumatic, and
anti-aging. Curcumin, the yellow polyphenolic compound extracted
from Curcuma longa species, is widely used in traditional
Ayurvedic medicine to prevent and contrast many diseases,
considering its antioxidant, immunomodulatory,
anti-inflammatory, anti-microbial, cardio-protective,
nephron-protective, hepato-protective, anti-neoplastic, and
anti-rheumatic proprieties. In recent years, the investigations
of curcumin have been focused on its application to aging and
age-associated diseases. Aging is a physiological process in
which there is a decreasing of cellular function due to internal
or external stimuli. Oxidative stress is one of the most
important causes of aging and age-related diseases. Moreover,
many age-related disorders such as cancer, neuroinflammation,
and infections are due to a low-grade chronic systemic
inflammation. Curcumin acting on different proteins is able to
contrast both oxidative stress than inflammation. In the brain,
curcumin is able to modulate inflammation induced by microglia.
Finally in brain tumors curcumin is able to reduce tumor growth
by inhibition of telomerase activity. This review emphasizes the
anti-aging role of curcumin focusing on its mechanism to
counteract aging in the brain.
Antioxidant effects of curcumin and neuroaging
Factors Affecting Neurological Aging | August 2021 Curcumin,
a plant-based polyphenol, is known to scavenge free radicals and
promote antioxidant activity. evidenced by brain
imaging studies is reviewed. Although there are limited
published clinical trials, there is preliminary evidence for
curcumin improving memory and decreasing amyloid-β plaque
accumulation. Consequently, curcumin has potential as a therapy
in aging and aging-related disorders and further studies on its
properties are warranted.
Pleiotropic nature of curcumin in strategies to
treat gastric cancer Phytotherapy Research
| August 2021 Curcumin, isolated from the rhizomes of
Curcuma longa L. has several medicinal properties like
antiinflammatory, antioxidant, antiapoptotic, antitumor, and
antimetastatic. Such pleiotropic nature of curcumin impedes the
invasion and proliferation of GC by targeting several oncogenic
factors like p23, human epidermal factor receptor2 including
Helicobacter pylori. The side effect of chemotherapy, that is,
chemotherapeutic resistance and radiotherapy could be reduced
combination therapy of curcumin. Moreover, the photodynamic
therapy of curcumin destroys the cancer cells without affecting
normal cells.
Targeting of the tumor microenvironment by curcumin
BioFactors | August 2021 Curcumin is a plant-derived agent
that has shown interesting properties for cancer therapy. It has
shown that not only directly inhibit the growth of cancer cells,
but can also modulate the growth and activity of
immunosuppressant and tumor-promoting cells. In this review, we
explain how curcumin modulates interactions within TME in favor
of tumor treatment. The potential modulating effects of curcumin
on the responses of cancer cells to treatment modalities such as
immunotherapy will also be discussed.
Effect of curcumin on proinflammatory cytokines: A
meta-analysis of randomized controlled trials
Cytokine | August 2021 Curcumin has the potential for
lowering inflammation. There was a significant decrease in
the serum levels of IL-1 and TNF-α compared to the placebo group
following treatment. The dose-responses analysis indicated
that curcumin/turmeric supplementation resulted in IL-1 and IL-8
alteration in a non-linear model. Subgroup analysis
according to duration and dose of treatment and target
population revealed diverse outcomes. Curcumin could have a
beneficial effect in reducing the proinflammatory cytokines IL-1
and TNF-α.
Antidiabetic Properties of Curcumin: Insights on New
Mechanisms Studies on Biomarkers and New
Targets in Aging Research | August 2021 Curcumin, a bioactive
polyphenol derived from Curcuma longa L., exhibits
therapeutic effects against diabetes while only negligible
adverse effects have been observed. Antioxidant and
anti-inflammatory properties of curcumin are the main and
well-recognized pharmacological effects that might explain its
antidiabetic effects. Additionally, curcumin may regulate novel
signaling molecules and enzymes involved in the pathophysiology
of diabetes, including glucagon-like peptide-1, dipeptidyl
peptidase-4, glucose transporters, alpha-glycosidase,
alpha-amylase, and peroxisome proliferator-activated receptor
gamma (PPARγ). Recent findings from in vitro and in vivo studies
on novel signaling pathways involved in the potential beneficial
effects of curcumin for the treatment of diabetes are discussed
in this review.
Curcumin: A Review of Its Effects on Epilepsy
Studies on Biomarkers and New Targets in Aging Research | August
2021 Curcumin (diferuloylmethane) is a major component of
Curcuma longa and exhibits
various pharmacological effects, including anti-inflammatory,
antioxidant, and immunoregulatory properties. Here, we have
reviewed the literature relating specifically to the
antiepileptic effects of curcumin. The evidence suggests a
protective effect of curcumin in the control of epileptic
seizures, together with a protective effect on the relief of
memory impairment, which may stem from its influence on
monoamine levels in the brain.
Curcumin for the Treatment of Prostate Diseases: A Systematic
Review of Clinical Trials Studies on
Biomarkers and New Targets in Aging Research | August 2021
Curcumin is a primary component of turmeric with several proven
health benefits and is considered as a safe natural agent for
both prevention and treatment of several diseases. It has been
shown that this active compound of turmeric has several unique
properties such as anti-tumour, anti-inflammatory, antioxidant,
antithrombotic, chemosensitising and chemopreventive,
anti-atherosclerotic and cardioprotective, lipid-modifying,
antibacterial, antifungal, antiviral, analgesic, antidepressant
and antirheumatic activities. Evidence suggests that curcumin
has anticancer activity and, based on preclinical studies, it
might be used to downregulate gene expression in prostate cancer
cells. Also, due to the anti-inflammatory effects of curcumin,
it has been suggested that this bioactive compound might have a
beneficial impact on BPH and other inflammatory prostate
conditions. The main finding of this systematic review is that
curcumin supplementation alone or in combination with the other
herbs had some favourable effects on prostate diseases without
any considerable adverse effects. In particular, curcumin
appeared to have anti-inflammatory effects which could offer
some therapeutic effects and improve patient outcomes.
The Clinical Use of Curcumin for the Treatment of Rheumatoid
Arthritis: A Systematic Review of Clinical Trials
Studies on Biomarkers and New Targets in Aging Research
| August 2021 Curcumin is one of the most studied hydrophobic
polyphenols, derived mainly from Curcuma longa L. (turmeric).
Curcumin has been widely and safely used in the treatment and
prevention of various diseases. The potential protective
mechanisms of curcumin have been claimed to be related to
antioxidant, anti-inflammatory, anti-microbial, neuroprotective,
anti-tumor, and immunomodulatory properties. Curcumin with
anti-antioxidant, anti-inflammatory, and immunomodulatory
properties might have beneficial effects on Rheumatoid
Arthritis. Rheumatoid factor was significantly reduced after
consumption of curcumin in all three relevant studies. None of
the studies reported serious adverse effects with curcumin
consumption. The present systematic review suggests that
curcumin could be used as a safe agent to treat Rheumatoid
Arthritis.
Effect of curcumin on proinflammatory cytokines: A meta-analysis
of randomized controlled trials Cytokine |
August 2021 Curcumin has the potential for lowering
inflammation. There was a significant decrease in the serum
levels of IL-1 and TNF-α compared to the placebo group following
treatment. The dose-responses analysis indicated that
curcumin/turmeric supplementation resulted in IL-1 and IL-8
alteration in a non-linear model. Subgroup analysis according to
duration and dose of treatment and target population revealed
diverse outcomes. Curcumin could have a beneficial effect in
reducing the proinflammatory cytokines IL-1 and TNF-α.
A Systematic Review of the Clinical Use of Curcumin
for the Treatment of Osteoarthritis Studies
on Biomarkers and New Targets in Aging Research | August 2021
There is growing evidence that curcumin has anti-inflammatory
properties and could be a potential therapeutic option for
chronic inflammatory diseases. Hence, curcumin could potentially
have a positive impact on osteoarthritis symptoms. There was a
significant improvement in VAS and overall WOMAC scores with
oral administration of various types of curcumin formulations
with no severe adverse effects. In conclusion, different types
of curcumin compounds may be beneficial as an alternative or
complementary agent for the management of osteoarthritis.
Neuroprotective Effects of Curcumin in Cerebral Ischemia
ACS Chemical Neuroscience | August 2021
Curcumin, a polyphenol that is abundantly present in the rhizome
of the turmeric plant (Curcuma longa), has shown promising
neuroprotective effects in animal models of neurodegenerative
diseases, including cerebral ischemia postischemic brain including
antioxidant, anti-inflammatory, antiapoptotic,
vasculoprotective, and direct neuroprotective efficacies.
Importantly, neuroprotective effects of curcumin has been
reported in both ischemic and hemorrhagic stroke models. A
broad-spectrum neuroprotective efficacy of curcumin suggested
that curcumin can be an appealing therapeutic strategy to treat
cerebral ischemia.
5 Science-Backed Health Benefits Of Curcumin
Forbes Health | July 2021
Effect of moderate exercises and curcumin on hepatic
transcriptional factors associated with lipid metabolism and
steatosis in elderly male rat
Integrative/Functional Medicine | July 2021 Moderate aerobic
exercise and curcumin alone or in combination completely masked
this effect. Conclusion and implications: The findings revealed
dyslipidemia and liver steatosis related to aging might be
partly associated with changes in hepatic transcriptional
factors which can be mitigatedmoderate aerobic exercise and
curcumin.
Promising
role of curcumin against viral diseases emphasizing COVID-19
management
Journal of Functional Foods
| July 2021 Curcumin has already acknowledged
immense interest from both medical and scientific research
because of its multifaceted activity. To date, the promising influenza and HIV. The
popular use of curcumin in research is mainly due to its
pleiotropic properties including anti-inflammatory, anti-oxidant
and anti-carcinogenic activities (Ahmad et al., 2020). Curcumin
can inhibit the inflammatory mediators, oxidation processes, and
oxidative stress thereby acts as an anti-inflammatory agent
against many diseases (Wal et al., 2019). Praditya et al.
(2019b) have shown curcumin as an anti-bacterial agent against
several strains of Staphylococcus, Streptococcus, Helicobacter
and Pseudomonas mainly by growth inhibition. They also reported
the anti-fungal property of curcumin. Different studies
identified the efficacy of curcumin against Human
immunodeficiency virus (HIV), Herpes simplex virus (HSV),
Hepatitis viruses etc. (Praditya et al., 2019a, Prasad and
Tyagi, 2015, Vitali et al., 2020). Although there are some
controversies, the majority of the studies support the potential
role of curcumin in inhibiting viral replication and growth
inhibition (Mathew & Hsu, 2018). Apart from these, long-term
intake of curcumin can improve systolic blood pressure (Hadi et
al., 2019), control obesity (Jarząb & Kukula-Koch, 2019), Type 2
Diabetes Mellitus (Pivari et al., 2019). Also, curcumin often
acts as a cardio-protective, nephroprotective, anti-neoplastic,
hepato-protective and anti-rheumatic compound. While the entire
world is putting efforts into the discovery of a vaccine against
coronavirus infection, the antiviral potential of curcumin
against SARS-CoV-2 shows a promising role in COVID-19
management. Since ancient time, curcumin possesses a
multifaceted role in several disease management. As an antiviral
agent, existing literature suggested that targeting viral
lifecycle and cellular responses are important strategies to
combat viral infection. The present review emphasized the
molecular mechanism of host-pathogen interaction and subsequent
immune response in the host. In this background, curcumin can
potentially inhibit the SARS-CoV-2 entry within human mainly by
blocking the ACE2 ced
multi-organ failure by constraining the inflammatory response
and other cellular immune response.
Curcumin inhibits the viability, migration and
invasion of papillary thyroid cancer cells
Experimental and Therapeutic Medicine | July 2021 Curcumin is
a main phenolic active compound in C. Longa Linn, and it has
numerous pharmacological activities such as anti-inflammatory,
antibacterial and, especially, anticancer activities. The
anticancer effects of curcumin are due to targeting a wide range
of cellular and molecular pathways involved in cancer
pathogenesis. For example, curcumin has been revealed to induce
endoplasmic reticulum stress-associated apoptosis in human PTC
cells via disruption of intracellular calcium homeostasis and to
affect PTC cells by targeting the JAK/STAT3 signaling pathway.
In summary, curcumin suppressed the cell viability, migration,
invasion and EMT of TPC-1 cells. Moreover, curcumin treatment
increased miR-301a-3p expression and inhibited STAT3 expression.
Overexpression of miR-301a-3p inhibited cell viability,
migration, invasion, and EMT and the JAK/STAT signaling pathway
by targeting STAT3, and miR-301a-3p inhibitors and STAT3
overexpression reversed the curcumin-induced cell viability,
migration, invasion and EMT of TPC-1 cells. Collectively,
curcumin played an anticancer role in TPC-1 cells by regulating
miR-301a-3p/STAT3, indicating that curcumin is a promising
oncotherapeutic agent. These findings may provide a possible
strategy for the clinical treatment of PTC.
Curcumin modulates gut microbiota and improves renal
function in rats with uric acid nephropathy
Renal Failure | July 2021 Curcumin is a natural phenolic
compound derived from the rhizome of the plant curcuma longa,
and it is the main ingredient of turmeric. A large number of
studies have confirmed that curcumin exerts a wide range of
biological effects, including anti-tumor, anti-inflammatory,
anti-oxidation, and anti-fibrosis. Based on the above
pharmacological effects, there have been many animal experiments
and cellular experiments using curcumin to prevent and treat
various kidney diseases in recent years, and even a few
preliminary reports on the clinical application of curcumin in
the treatment of renal diseases. Moreover, curcumin has also
been shown to have the effects of regulating intestinal flora
and improving gut barrier function in multiple diseases, like
diabetes, ulcerative colitis, and colorectal cancer. Curcumin
treatment protected against the overgrowth of opportunistic
pathogens in UAN, including Escherichia-Shigella and
Bacteroides, and increased the could modulate gut microbiota, fortify the
intestinal barrier, attenuate metabolic endotoxemia, and
consequently protect the renal function.
Anti-inflammatory effects of curcumin in acute lung
injury International Immunopharmacology |
July 2021 Curcumin reduces pyroptosis by inhibiting the
expression of NLRP3. In conclusion, curcumin has protective
effect against acute lung injury. It may inhibit inflammatory
process by inhibiting the activation of NLRP3
inflammasome-dependent pyroptosis through the up-regulation of
SIRT1.
A Novel Potent Sleep-Promoting Effect of Turmeric
Molecular Nutrition & Food Research | June 2021 Turmeric
extract has a sleep-promoting effect owing to reduction in sleep
latency and enhancement of NREMS via H1R blockade; therefore, it
could be useful in insomnia.
Curcumin inhibits classical swine fever virus
replication Microbiology | June 2021
Previous reports have shown that Curcumin inhibits many
viruses, including some important members of different genera of
Flaviviridae family (Japanese encephalitis virus, dengue virus
and hepatitis C virus). Curcumin inhibited classical swine fever
virus replication by interfere lipid metabolism. In addition,
our subsequent studies found that curcumin played an antiviral
role by promoting the innate immune independent of NF-κB
signaling pathway. Taken together, our finding highlights that
curcumin is a potential candidate drug against classical swine
fever virus for controlling classical swine fever.
Curcumin reverses doxorubicin resistance in colon
cancer cells at the metabolic level Journal
of Pharmaceutical and Biomedical Analysis | June 2021 Natural
product curcumin was demonstrated to have a variety of
pharmacological effects, such as anti-tumor, anti-oxidation and
anti-aging activities. Curcumin increased the cytotoxicity
of Dox in SW620/Ad300 cells. Curcumin reduced the biosynthesis
of polyamine and D-glutamine metabolism to reverse MDR. Curcumin
inhibited the ODC expression, thererby decreasing the
biosynthesis of polyamine. Curcumin could be a promising
multidrug-resitance reversal agent for cancer treatment.
Curcumin suppresses the malignancy of non-small cell lung cancer
Biomedicine & Pharmacotherapy | June 2021 Curcumin
exerts a suppressive effect in tumor growth by acting as a
modulator of multiple molecular targets. Curcumin, a
traditional herbal medicine, is discovered in Curcuma longa. It
is a polyphenol and has many activities, including controlling
diabetes, improving brain function, oxidation,
anti-inflammatory, anti-tumor, and so on. It has been reported
that curcumin plays an important role in various cell signal
transduction by acting as a modulator of multiple molecular
targets. Also, curcumin plays a repressive role in the
advancement of NSCLC. Zhang et al. manifested that curcumin
synergistically constrained cell malignancy. Furthermore,
curcumin played an anti-tumor activity in NSCLC cells. Curcumin
has attracted the attention of scientific researchers all over
the world because of its anti-cancer potential. Accumulated
studies have revealed that curcumin can target cell signaling
pathways related to cancer development. For example, curcumin
elevated miR-99a expression in retinoblastoma cells, thereby
blocking the JAK/STAT pathway and repressed cell malignancy.
Moreover, curcumin inhibited the proliferation of glioblastoma
cells via blocking the AKT/mTOR pathway. Recent research
revealed that curcumin elevated nasopharyngeal cancer
radio-sensitization through regulating the circRNA/miR/mRNA
network. Herein, we discovered that curcumin curbed the
malignancy of NSCLC cells through repressing the
circ-PRKCA/miR-384/ITGB1 pathway.
Curcumin and rheumatoid arthritis: A systematic review
of literature International Journal of
Clinical Practice | June 2021 Curcumin is a natural
polyphenol and the main compound from the rhizome of Turmeric
(Curcuma longa) and other Curcuma species. It has been widely
used for different medical purposes, such as improvement of pain
and inflammatory conditions in various diseases. Most studies
have shown the curative effects of curcumin on clinical and
inflammatory parameters of RA and reported different mechanisms;
inhibition of mitogen-activated protein kinase family,
extracellular signal-regulated protein kinase, activator
protein-1 and nuclear factor kappa B are the main mechanisms
associated with the anti-inflammatory function of curcumin in
RA. The results of the only human study showed that curcumin
significantly improved morning stiffness, walking time and joint
swelling. In conclusion, curcumin seems to be useful, and it is
recommended that more human studies be performed to approve the
cellular and animal results and determine the effective and
optimal doses of curcumin on RA patients.
The efficacy and safety of Curcuma longa Extract and
curcumin supplements on osteoarthritis: a systematic review and
meta-analysis Bioscience Reports | June
2021 Curcuma longa Extract and curcumin may be a safer and
effective supplement for osteoarthritis patients. It is
recommended to use Curcuma longa Extract and curcumin supplement
for osteoarthritis patients for more than 12 weeks. Curcumin is
a natural active oxygen scavenger and active nitrogen provider,
and has been proven to be effective in treating pain caused by
arthritis and osteoarthritis. Compared with NSAIDs, Curcuma
longa Extract and curcumin have similar effects on joint pain,
function and stiffness. However, the incidence of adverse events
in Curcuma longa Extract and curcumin was lower. Compared
with the NSAIDs group, Curcuma longa Extract and curcumin+NSAIDs
can also relieve pain (decrease the VAS and WOMAC score-pain),
improve the joint function (decrease the WOMAC score-function),
and improve the joint stiffness (decrease the WOMAC
score-stiffness); in terms of adverse events, the addition of
Curcuma longa Extract and curcumin to NSAIDs did not increase
adverse events. Our meta-analysis also showed that Curcuma longa
Extract and curcumin can improve oxidative stress in patients
with osteoarthritis. Our meta-analysis shows that the
combination of Curcumin and NSAIDs does not increase the
occurrence of adverse events and has better efficacy. This is a
promising result, because adding Curcumin supplementation in the
case of using NSAIDs may increase the efficacy and perhaps
reduce the dosage of NSAIDs.
Study presents evidence supporting the use of
curcumin as alternative treatment for kidney fibrosis
The Gary Null Show | June 2021 Curcumin is an effective
alternative treatment for renal fibrosis According to several
animal studies, curcumin can protect the kidneys by preventing
the development of renal fibrosis. The researchers found that
curcumin (3.125 and 25?micromol/L) effectively promoted HKC
proliferation. After 72 hours of incubating HKCs with TGF-B1 and
curcumin, curcumin caused the cells to maintain epithelial
morphology in a dose-dependent manner. It also decreased the
expression of EMT-related proteins, such as vimentin, a-SMA and
FSP1, and increased the expression of E-cadherin and
cytokeratin. In addition, the researchers noted that curcumin
reduced Akt, mTOR and P70S6K phosphorylation, which effectively
suppressed the activation of the Akt/mTOR pathway in HKCs. Based
on these findings, the researchers concluded that curcumin is an
effective alternative treatment for renal fibrosis because it
can promote HKC proliferation and stop EMT by inhibiting the
activation of the Akt/mTOR pathway activity.
The Role of Curcumin in Gastrointestinal Cancers
Advances in Experimental Medicine and Biology |
June 2021 Curcumin has been used in combinations with many
anti-tumor drugs to increase their anticarcinogenic properties.
Taken together, curcumin falls within the category of
plant-derived substances capable of preventing or treating
gastrointestinal cancers. Curcumin is a natural compound derived
from turmeric with a wide range of biological activities.
Several in vitro and in vivo studies have investigated the
effects of curcumin on gastrointestinal cancers. In the current
review, we aimed to provide an updated summary on the recent
findings regarding the beneficial effects of curcumin on
different gastrointestinal cancers in the recent curcumin
can inhibit cell growth through cycle arrest at the G2/M and G1
phases, as well as stimulated apoptosis and autophagy by
interacting with multiple molecular targets. In vivo studies
performed in various animal models have confirmed mainly the
chemopreventive effects of curcumin.
Effect of eight-week curcumin supplementation with
endurance training on glycemic indexes in middle age women with
type 2 diabetes Diabetes & Metabolic
Syndrome: Clinical Research & Reviews | June 2021 Eight weeks
of curcumin supplementation and endurance training, whether done
separately or simultaneously, significantly reduced fasting
blood glucose, glycosylated hemoglobin and serum insulin levels
(P < 0.05). The combination of curcumin supplementation and
endurance training compared to the other two interventions
caused a significant further decrease in these glycemic indexes
(P < 0.05). The findings of this study showed that eight weeks
of curcumin supplementation and endurance training helped each
other in improving the glycemic indexes of women with type 2
diabetes.
The protective effect of curcumin on rats with
DSS-induced ulcerative colitis and its mechanisms
Research Square | May 2021 Curcumin is a traditional Chinese
herbal medicine that is used for anti-inflammation in China and
Southeast Asia. Curcumin has antioxidant, anti-inflammatory,
anticancer and antiapoptotic properties. The advantages of
curcumin, such as few adverse reactions, high levels of safety,
and good compliance, have attracted the attention of many
researchers. Studies have shown that curcumin can reduce airway
inflammation by regulating the balance of Treg/Th17 cells in
asthma models. In IBD model mice with genetic deletion of IL-10,
an emulsion of curcumin in sodium carboxymethyl cellulose
induced anti-inflammatory effects. The curcumin group exhibited
significantly reduced DAI scores and improvements in
histopathological damage. The expression of CD4+IL-17+ Th17
cells was significantly lower and the expression of
CD4+CD25+Foxp3+ Treg cells was significantly higher in the
curcumin group than in the DSS group. Curcumin may be a
new and effective treatment for IBD by regulating the balance of
Treg/Th17 cells and the expression of IL-10 and IL-17A. The
present study showed that compared with those of IBD rats in the
DSS group, IL-10 levels of IBD rats in the curcumin group were
significantly higher. Therefore, the protective effect of
curcumin was related to IL-10. In summary, curcumin attenuated
colonic tissue damage in DSS-induced UC rats by improving the
Treg/Th17 cell balance and influencing the expression of
inflammatory cytokines.
Curcumin promotes cell cycle arrest and apoptosis of
acute myeloid leukemia cells
Oncology Reports | May 2021 Curcumin, a phytochemical from
rhizomes of the plant Curcuma longa, has been reported to exert
potential anticancer properties in various cancer types,
including acute myeloid leukemia (AML). Collectively, the
present study demonstrated that curcumin exerted anti-AML roles
by inactivating AKT and these findings may aid in the treatment
of AML.
Effects of curcumin supplementation on sport and
physical exercise Critical Reviews in Food
Science and Nutrition | May 2021 Curcumin supplementation
displayed significant reductionof inflammation derived from the
physical exercise. After curcumin supplementation there was a
significantimprovement in some aspects of muscle recovery and
performance in exercise. Curcumin has recently drawn worldwide
attention ofresearchers (Salehi et al.2019), who conducted
studies thatindicated that its medicinal properties are
associated withthe reduction of pain (Karlapudi et al.2018; Sun
et al.2018), anti-inflammatory effects (Ghandadi and
Sahebkar2017; Mollazadeh et al.2019), besides prevention and
treat-ment of cardiovascular (Li et al.2020; Momtazi-Borojeniet
al.2019) and gastrointestinal (GI) diseases (Ghosh et al.2018;
Mazieiro et al.2018), cancer (Kunnumakkara et al.2017; Mizumoto
et al.2019; Talib et al.2018) and otherchronic diseases (Kunwar
and Priyadarsini2016; Prasadet al.2014; Salehi et al.2019;
Sharan Patel et al.2019).Also, studies that employed animal
models reportedpositive results of curcumin supplementation for
physicalactivity and sport performance (Huang et al.2015),
thussupporting muscle recovery and reduction of
inflammation(Davis et al.2007), improvement of mitochondrial
biogen-esis (Ray Hamidie et al.2015), reduction of oxidative
stress(Kawanishi et al.2013), prevention of fatigue and
muscledamage (Huang et al.2015; Sahin et al.2016). The
evidences presented indicate that cur-cumin supplementation in
human beings is likely safe andbeneficial for sport and physical
activity, due to the reduction of inflammation and oxidative
stress, reduction of painand muscle damage, improved muscle
recovery, sport performance, psychological and physiological
responses (thermal and cardiovascular) during training, as well
as the GI function.
Role of Curcumin in Regulating Long Noncoding RNA
Expression in Cancer Advances in
Experimental Medicine and Biology | May 2021 Phytochemicals
are various compounds produced by plants. There is growing
evidence on their potential health effects. Some of these
compounds are considered as traditional medicines and used as
painkillers, anti-inflammatory agents, and for other
applications. One of these phytochemicals is curumin, a natural
polyphenol derived from the turmeric plant (Curcuma longa L.).
Curcumin is widely used as a food coloring, preservative and
condiment. It has also been shown to have antioxidative and
anti-inflammatory effects. Moreover, there is growing evidence
that curcumin alters long noncoding RNAs (lncRNAs) in many kinds
of cancer. These noncoding RNAs can cause epigenetic modulation
in the expression of several genes. This study reviews reports
of curcumin effects on lncRNAs in lung, prostate, colorectal,
breast, pancreatic, renal, gastric, and ovarian cancers.
The effect of curcumin and zinc co-supplementation
on glycemic parameters in overweight or obese prediabetic
subjects Phytotherapy Research | May 2021
Curcumin and zinc have been studied as an antioxidant,
antiinflammatory, and antidiabetic agents. Based on these
results, zinc and curcumin supplementation exerted a beneficial
effect on several key glycemic parameters.
Curcumin Reduces Neuroinflammation and Improves the
Impairments of Anesthetics on Learning and Memory
Neuroimmunomodulation | May 2021 Curcumin has a protective effect
on ISO-induced cognitive dysfunction, which may be achieved by
regulating the expression of miR-181a-5p.
Curcumin: A small molecule with big functionality
against amyloid aggregation in neurodegenerative diseases and
type 2 diabetes
BioFactors | May 2021 we discuss clinical trials in which curcumin is
used as a therapeutic agent for the treatment of diseases
linking to protein aggregates.
Anti-Inflammatory Effect of Curcumin on Rheumatoid
Arthritis Pharmaceuticals | May 2021
Recent studies reveal that curcumin, a natural dietary
anti-inflammatory compound, can modulate the response of the
cells engaging in RA course. Interestingly, many studies have
described the potential role of curcumin as an epigenetic
modifier. This potent herbal drug has been identified as an
inhibitor of DNA methyltransferases (DNMTs), regulator of
histone acetyltransferases (HATs), deacetylases (HDACs), and
microRNAs, as well as a DNA binding agent. Curcumin has been
found to significantly reduce H3ac levels in the IL-6 promoter
as well as IL-6 mRNA expression in rheumatoid arthritis synovial
fibroblasts (RASFs). The role of curcumin as an epigenetic
modifier has been well documented in cancer, neurological
disorders, and some inflammatory diseases. Curcumin is a
polyphenolic substance naturally occurring in turmeric,
especially in Curcuma Longa, with broad anti-inflammatory
properties and proven positive effects in autoimmunological
disease therapies, including Rheumatoid Arthritis. Curcumin is
an antioxidant, which means it can efficiently reduce the level
of reactive oxygen species (ROS), weaken redox signaling, and
reduce inflammation [22]. In addition to having direct
antioxidant properties, curcumin also blocks the activity of
ROS-generating enzymes like lipoxygenase (LOX), cyclooxygenase
(COX), xanthine dehydrogenase, and nitric oxide synthase (iNOS).
Despite reducing ROS levels, curcumin also possesses numerous
other properties that enable its usage as a potential
therapeutic drug targeted against Rheumatoid Arthritis.
Interesting insights into this matter are provided by recent
studies, which found that this natural compound can suppress
proinflammatory pathways related to the immune cells crucial in
RA development. Therefore, curcumin’s daily consumption can
decrease inflammation and oxidative stress, contributing to the
immune system’s modulation and alleviating the rheumatoid
arthritis course.
Curcumin and cancer biology: Focusing regulatory effects in
different signalling pathways Phytotherapy
Research | May 2021 Curcumin is a bright yellow substance
isolated from the plant rhizomes of Curcuma longa L. To this
molecule a high therapeutic benefit has been underlined, being
able to alter the development of cancer by different mechanisms,
such as regulating multiple microRNA expression, modifying a
series of signalling pathways.
Curcumin alleviates high-fat diet-induced hepatic steatosis and
obesity in association with modulation of gut microbiota in mice
Food Research International | May 2021
Curcumin alleviated hepatic steatosis and insulin
resistance in obese mice. Curcumin increased abundance of
Bacteroides, Parabacteroides, Alistipes and Alloprevotella.
Curcumin increased the caecal and colonic short chain fatty
acids (SCFA) contents. Curcumin reduced endotoxin-producing
Desulfovibrio bacteria and circulating serum LPS. The dominant
bacterial taxa altered by curcumin were related with improvement of
obesity.
The Effects of Curcumin on Diabetes Mellitus: A Systematic
Review Frontiers in Endocrinology | May
2021 The genus Curcuma
(Zingiberaceae) includes perennial rhizomatous plants
native to subtropical to tropical regions. The main part of the
plant is the rhizomes, and the most prevalent active components
are the curcuminoids (curcumin, demethoxycurcumin, and
bisdemethoxycurcumin). Curcuminoids are nontoxic polyphenolic
that exerts a wide range of biological activities, such as the
production of significant immunosuppressants that inhibit the
production of IL-2 and IL-12. This compound inhibits the
expression of iNOS (inducible nitric oxide synthase), COX-2
(cyclooxygenase-2), lipoxygenase-5, and many other
pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6, and IL-8.
Curcuminoids can also regulate apoptosis and suppress neurotoxic
factors in macrophages and alveolar monocytes stimulated by
lipopolysaccharides. Besides, it inhibits phosphorylation and
degradation of IκBα (nuclear factor of kappa light polypeptide
gene enhancer in B-cells inhibitor, alpha) and activates the γ
receptor mechanism activated by peroxisome proliferator,
reducing inflammation pattern induced by NF-κBe biological effects may include the inhibition of reactive
oxygen species (ROS) production, playing a fundamental role,
particularly for diseases related to oxidative stress and
inflammation, such as DM. Figure 3 shows some systemic effects
of curcumin. Curcumin is a bioactive component found Curcuma
longa, which exhibits several physiological and pharmacological
properties such as antioxidant, anti-inflammatory, anticancer,
neuroprotective, and anti-diabetic activities. For these
reasons, our objective is to systematically review the effects
of Curcuma longa or curcumin on DM. Databases such as
PUBMED and EMBASE wereto its capacity to suppress oxidative stress and
inflammatory process. Also, it significantly reduces fasting
blood glucose, glycated hemoglobin, and body mass index. The
singular characteristic of this plant is the presence of
curcumin, which shows antioxidant and anti-inflammatory
properties. Besides that, curcumin has a potential role in
preventing and treating several diseases due to various actions
such as anti-bacterial, anti-diabetic, anti-viral, and
anticancer activities. Curcuminoids have been shown to improve
insulin resistance, decrease glucose and insulin levels,
increase adiponectin release, and reduce the levels of leptin, resistin, interleukin (IL)-6 IL-1β, and tumor necrosis factor-α
in patients with T2DM. These findings suggest that these
compounds can affect glucose homeostasis and diabetic
complications, and the vascular risk of patients with T2DM. Some
studies have shown that supplementation of curcuminoids improves
the lipid profile and increases the total antioxidant capacity
of patients with T2DM, thus supporting other available evidence
on the role of curcuminoids in modifying cardiometabolic risks.
Possible Mechanisms and Special Clinical
Considerations of Curcumin Supplementation in Patients with
COVID-19 Advances
in Experimental Medicine and Biology | May 2021 Mechanisms
and special clinical considerations of supplementation with
curcumin as an anti-inflammatory and antioxidant compound in the
setting of COVID-19 clinical research.
Anticancer
Mechanism of Curcumin on Human Glioblastoma
Nutrients | May 2021 Curcumin is the most studied
compound described as a potential anticancer agent due to its
multi-targeted signaling/molecular pathways properties. Curcumin
possesses the ability to modulate the core pathways involved in
GBM cell proliferation, apoptosis, cell cycle arrest, autophagy,
paraptosis, oxidative stress, and tumor cell motility. This
review discusses curcumin's anticancer mechanism through
modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-κB
pathways, which are commonly involved and dysregulated in
preclinical and clinical GBM models.
Micronutrients and bioactive substances: Their
potential roles in combating COVID-19
Nutrition | April 2021 A study has shown that curcumin
interfered with the binding of enveloped viruses to cell
surface. Derivatives of curcumin exhibited antiviral activity
against the
vesicular stomatitis virus. Curcumin also exhibited antiviral
properties against dengue virus and hepatitis C virus. Having
immunomodulating, antiinflammatory, antioxidant, and antiviral
properties, such micronutrients and bioactive substances are
consequently promising alterative nutritional approaches to
combat COVID-19 infection.
Curcumin suppresses colorectal cancer stem cells
Journal of Natural Medicines | April 2021
Curcumin is a polyphenol extracting from
Curcuma longa. It has been demonstrated that curcumin
possesses extensive therapeutic activities against multiple
ailments, such as inflammation, metabolic syndrome, liver
disease, arthritis, and neurodegenerative disease. In the recent
years, researchers found that curcumin has played an important
role in cancer prevention and treatment. For instance, curcumin
induced apoptosis of castration-resistant prostate cancer cells,
partially dependent on its iron-chelating properties; curcumin
could overcome gefitinib-resistance in nonsmall-cell lung cancer
cells via inducing autophagy-related cell death. Other studies
indicated curcumin suppressed oncogenicity of human colon cancer
cells, through covalent modification of SIRT1 at the cysteine 67
residue and the proteasomal degradation of oncogenic SIRT1. In
this study, we observed that curcumin inhibited tumorsphere
formation, decreased cell viability in a dose-dependent manner.
Curcumin also promoted apoptosis of LGR5(+) colorectal CSCs. In
addition, curcumin can induce autophagy in many tumor cells. For
example, curcumin inhibited proliferation, induced the autophagy
and apoptosis in gastric cancer cells. Similarly, our data
suggest that curcumin increased tumor cell death partly by
inducing autophagy, because the effect of curcumin-induced cell
proliferation inhibition was decreased by co-treatment with the
autophagy inhibitor, HCQ. Therefore, these results reveal that
curcumin-induced autophagy may contribute to the antitumor
effects of curcumin on LGR5(+) colorectal CSCs. In
summary, we found that curcumin suppresses the proliferation of
LGR5(+) colorectal CSCs by inducing autophagy and
transcriptionally repressing the oncogenic TFAP2A-mediated ECM
pathway. Lastly, while our study entailed mostly in vitro
experiments, further studies, especially in vivo, are needed to
understand the mechanism of effect of curcumin in LGR5(+)
colorectal CSCs and to evaluate this potential therapeutic
approach to CRC. In addition, the correlation between
TFAP2A-mediated ECM pathway and autophagy also deserves further
study.
Beneficial Effects of Curcumin Supplementation on Sports
Performance and Physical Exercise Designs
For Health | April 2021 Turmeric has three main bioactive
components: curcumin, desmethoxycurcumin, and
bisdemethoxycurcumin. These curcuminoids have many biological
effects, including properties that are anti-inflammatory,
antioxidant, anti-tumor, antimicrobial, and antiviral. This
review investigated the evidence for the effects of curcumin
supplementation for humans on sports performance and physical
exercise. Curcumin possesses the ability to inhibit
transcription factors (e.g., nuclear factor [NF]-κβ) that are
responsible for activating pro-inflammatory enzyme and cytokine
expression, such as cyclooxygenase (COX)-2, 5-lipoxygenase
(LOX-5), tumor necrosis factor (TNF)-α, interleukin (IL)-1,
IL-6, and IL-8, suggesting their importance in helping to reduce
post-exercise inflammation. The treatment groups with doses
ranging from 180 mg to 5 g of curcumin per day showed
significant reductions in inflammation caused by physical
exercise compared to the placebo group, whose participants
displayed elevated IL receptor agonist activity of IL-6, IL-8,
and IL-10, and TNF-α concentrations. Compared to the treatment
group, a gastrointestinal (GI) barrier damage marker (fatty
acid−binding protein) was elevated after aerobic exercise in the
placebo group, suggesting curcumin may improve GI function
during exercise-induced exertional heat stress. Overall, the
results of this systematic review showed positive effects with
no adverse symptoms or injuries reported. Curcumin
supplementation improved exercise-induced muscle recovery,
muscle performance, psychological and physiological parameters,
function, and reduced inflammation, oxidative stress, pain, and
muscle damage caused by aerobic and resistance training.
Although larger clinical trials are needed, the evidence
suggests that curcumin supplementation may be a safe and
effective option for supporting sports and exercise performance
in humans.
Curcumin suppresses colorectal tumorigenesis
Oncology Letters | April 2021 Curcumin, a natural product
extracted from the rhizome of Curcuma longa, is a drug
with strong pharmacological effects and limited side effects.
Increasing evidence have confirmed that curcumin exerts
antioxidant, antibacterial, anti-inflammatory, antiproliferation
and anticancer effects. Furthermore, curcuminoids have advanced CRC who were resistant to chemotherapy for 4
months. The results demonstrated that treatment with curcumin was
well tolerated and there was no toxicity at any doses. Previous
studies have reported several molecular mechanisms for the
anticancer effects of curcumin . For example, curcumin inhibits
Axin2 expression in the colorectal cancer line, HCT116, and
modulates the Wnt/β-catenin signaling pathway. Yan et al
demonstrated that Axin2 is upregulated and the Wnt/β-catenin
signaling pathway is activated in human colon tumor samples. It
has also been reported that curcumin can target colorectal stem
cells via the Wnt pathway to inhibit their proliferation and
drug resistance to chemotherapy, indicating the important role
of the Wnt/β-catenin signaling pathway in the tumorigenesis of
CRC. Another study demonstrated that curcumin inhibits the
proliferation and induces apoptosis of human non-small cell lung
cancer cells via the PI3K/Akt signaling pathway. Furthermore,
the results of a squamous cell carcinoma study reported that
curcumin inhibits cancer cell proliferation via the epidermal
growth factor receptor signaling pathway. In addition to the
effects of curcumin on CRC progression through the
NBR2/AMPK/mTOR pathway, curcumin regulates the NF-κB and Src
protein kinase signaling pathways by inhibiting IκBα kinase
activation and IκBα phosphorylation. Collectively, these results
indicate several molecular mechanisms of the anticancer effects
of curcumin in vitro. However, the in vivo mechanism remains to
be elucidated. Thus, the present study aimed to investigate the
anticancer effects of curcumin and determine its underlying
mechanisms in CRC, in vivo.
Protective Effects of Curcumin on Sperm and
Stereological Parameters in Testes of Formaldehyde-Exposed NMRI
Mice: An Experimental Study
International Journal of Medical Laboratory | April 2021
Curcumin (diferuloylmethane) is the main curcuminoid of
turmeric, which is a known spice. It has been shown that
curcuminoids are polyphenols and are responsible for the
yellow-orange color of turmeric. Noorafshan and colleagues
previously showed that curcumin protects the Leydig cells
against metronidazole treatments. In another study, curcumin
reduced testicular damage in diabetic rats by reducing oxidative
stress.Moreover, Farombi et al. used curcumin to prevent
oxidative changes and enhance sperm motility and reduce sperm
abnormalities. This study showed that curcumin could reduce
formaldehyde-induced damage to
Telomerase: A Target for Therapeutic Effects of
Curcumin in Cancer Advances in Experimental
Medicine and Biology | April 2021 Curcumin has been shown to
be effective against several types of malignancies and has also
been shown to have inhibitory effects on telomerase activity.
Based on the findings obtained from the different studies here,
we conclude that the telomerase inhibitory effects of curcumin
are integral to its anticancer activity, and thus curcumin may
be useful therapeutically in the cancer field.
Curcumin as Anti-infective Agents
Current Medicinal Chemistry | April 2021 Curcumin, a
redox-active natural product, has for centuries been used in
Asian traditional medicine for the treatment of various
diseases. It is known for possessing multiple biological and
pharmacological activities. Curcumin has been investigated
extensively over the years for its anti-inflammatory,
anticancer, antiparasitic, antiviral and antibacterial
activities, and no toxicity is associated with the compound.
Curcumin is still in clinical trials for the treatment of
diseases
The Antioxidant Effect of Curcumin and Rutin on Oxidative
Stress Biomarkers Molecules | April 2021
Curcumin, from the root of the turmeric plant Curcuma longa, is
an extended pseudosymmetric polyphenol (diferuloylmethane). Zhou
et al. showed that curcumin prevents bone loss in an
experimental periodontitis model. In association with studies
that do demonstrate an effect on the prevention of bone loss,
these investigations have shown that curcumin has a profound
effect on inflammation by significantly reducing the development
of an inflammatory infiltrates within the periodontal lesion
while simultaneously stimulating an increase in the collagen
content, as well as an increase in the number of fibroblastic
cells within the periodontium and associated lesions when
curcumin was administered daily to rats with experimentally
induced periodontitis. Curcumin, the major component of
turmeric, has been shown to have anti-inflammatory,
antimicrobial and antioxidant action. In vitro studies, animal
studies and clinical studies have demonstrated that there is a
positive association between curcumin and the evolution of
periodontitis. It can be concluded that the oral administration
of curcumin and rutin, single or combined, could reduce
oxidative stress both in gingival tissue and blood and enhance
the antioxidant status in hyperglycemic periodontitis rats.
Modeling oxidative stress, these two antioxidants may have an
inhibitory effect on inflammation.
Curcumin induces ferroptosis in non‐small‐cell lung
cancer Thoracic Cancer | April 2021
Emerging studies showed curcumin can inhibit glioblastoma and
breast cancer cells via regulating ferroptosis. Curcumin is a
yellow polyphenol compound derived from the turmeric plant,
which shows anticancer properties through a variety of
mechanisms, including inhibition of tumor proliferation,
invasion and metastases, regulation of apoptosis, and autophagy.
Recent studies showed that curcumin can treat glioblastoma and
breast cancer via regulating ferroptosis. In conclusion, our
results provide evidence that curcumin could induce ferroptotic
cell death of NSCLC cells via activating autophagy.
Curcumin Ameliorated Oxidative Stress and
Inflammation-Related Muscle Disorders
Antioxidants | April 2021 Curcumin has also been reported to
possess diverse pharmacological effects including antioxidant
and anti-inflammatory activities. Recently, it has been
suggested that curcumin alleviated chronic kidney
disease-induced muscle atrophy by inhibiting glycogen synthase
kinase (GSK)-3β. The present study demonstrated that
curcumin in C2C12 myoblast cells showed in vitro
antioxidant and anti-inflammatory activities. Specifically,
curcumin enhanced DPPH radical scavenging activity in a
dose-dependent manner, and it did not affect the cell viability
of C2C12 cells with concentrations up to 30 μg/mL. Furthermore,
curcumin significantly suppressed H2O2-induced cell toxicity,
ROS generation, and lipid peroxidation and restored GSH
depletion, which involved an increase of antioxidant genes
through Nrf2 activation, providing evidence that curcumin can
protect cells by reducing oxidative stress. Besides, curcumin
significantly inhibited LPS-mediated IL-6 productions.
Therefore, curcumin could be a useful candidate against
oxidative stress and inflammation-related muscle disorders.
Curcumin Reduces Cognitive Deficits by Inhibiting
Neuroinflammation ACS Omega | April
2021 Curcumin is a polyphenolic substance extracted from
turmeric, a plant of the curcuma family. Toxicity studies have
shown that it is quite safe even at high doses the United States. Curcumin, as an effective
anti-inflammatory small molecule, was shown to inhibit the COX-2
expression in human colon cancer cells. Recently, Wang et al. have proven that curcumin can
inhibit ApoE4-induced injury by upregulating the expression of
peroxisome proliferator-activated receptor-γ to inhibit the
activation of NF-κB signaling in SH-SY5Y cells. Apart from the
anti-inflammatory role, curcumin also acts as a known
antioxidant that scavenges reactive oxygen species. Zheng et al.
found that curcumin can protect SH-SY5Y cells against
appoptosin-induced intrinsic caspase-dependent apoptosis by
increasing heme oxygenase-1 expression and reducing ROS
production. Chhunchha et al. also proposed that curcumin
could reinforce the naturally occurring Prdx6 expression,
attenuate ROS-based ER stress and NF-κB-mediated aberrant
signaling, then improve the survival of mouse hippocampal cells
(HT22), and may provide an osteoarthritis development in
vivo. Together, the previous studies focused either on the
anti-inflammatory effect of curcumin in vitro under various
stimuli or on its protection against ER stress in other
inflammatory diseases.
Curcumin protects against inflammation and lung
injury in rats with acute pulmonary embolism
Molecular and Cellular Biochemistry | April 2021 Curcumin
decreased miR-21 expression by downregulating Sp1 to upregulate
PTEN and to impair the NF-κB signaling pathway, thus suppressing
lung injury and inflammation in APE rats.
Antiviral and immunomodulatory activity of curcumin: A case for
prophylactic therapy for COVID-19 Heliyon
Cell Press | March 2021 Curcumin, a bioactive compound in
turmeric, exerts diverse pharmacological activities and is
widely used in foods and traditional medicines. This review
presents several lines of evidence, which suggest curcumin as a
promising prophylactic, therapeutic candidate for COVID-19.
First, curcumin exerts antiviral activity against many types of
enveloped viruses, including SARS-CoV-2, by multiple mechanisms:
direct interaction with viral membrane proteins; disruption of
the viral envelope; inhibition of viral proteases; induce host
antiviral responses. Second, curcumin protects from lethal
pneumonia and ARDS via targeting NF-κB, inflammasome, IL-6 trans
signal, and HMGB1 pathways. Third, curcumin is safe and
well-tolerated in both healthy and diseased human subjects. In
conclusion, accumulated evidence indicates that curcumin may be
a potential prophylactic therapeutic for COVID-19 in the clinic
and public health settings.
Curcumin suppresses the stemness of non‐small cell
lung cancer cells Environmental Toxicology
| March 2021 Curcumin has been shown to suppress the
progression of lung cancer, however, the underlying mechanisms
are largely unknown. Our results suggest that curcumin can
attenuate the stemness of lung cancer cells through promoting
TAZ protein degradation and thus activating Hippo pathway.
The Effect of Curcumin Supplementation on Overweight or Obese
Adults Nutrients | 2021 Curcumin has
been shown to play a beneficial role in obesity management.
Therefore, exploring the effects of certain herbs or dietary
spices on obesity may be promising. Among these spices,
curcumin, which is the primary component of the spice turmeric,
has gained great interest for its multiple health benefits.
Several randomized controlled trials have investigated the
potential favorable effects of curcumin supplementation on
anthropometric measures. The aim of this review is to evaluate
the effect of curcumin supplementation on the anthropometric
indices among overweight or obese adults. Curcumin
supplementation may exert beneficial effects against obesity
among overweight or obese adults.
Anticancer Mechanism of Curcumin on Human Glioblastoma
Nutrients | 2021 Curcumin is the most studied compound
described as a potential anticancer agent due to its
multi-targeted signaling/molecular pathways properties. Curcumin
possesses the ability to modulate the core pathways involved in
GBM cell proliferation, apoptosis, cell cycle arrest, autophagy,
paraptosis, oxidative stress, and its anticarcinogenic, antitumor, antioxidant, and
anti-inflammatory actions. Curcumin is the most abundant
compound and has been widely studied as a potential therapeutic
agent in chronic diseases, such as neurodegenerative,
cardiovascular, pulmonary, metabolic, and autoimmune diseases.
For instance, curcumin was able to restore oxidative stress and
DNA methyltransferase (DNMT) functions against diabetic
retinopathy. Curcumin also acts as a wound healing promoting
agent by facilitating collagen synthesis and fibroblast
migration. Several pre-clinical and clinical studies also
reported its anticancer effects in colorectal cancer, pancreatic
cancer, lung cancer, and GBM. Curcumin can modulate multiple
cellular signaling pathways and molecular targets involved in
GBM tumor growth, migration, invasion, cell death, and proliferatio. Retinoblastoma (Rb), p53, MAP kinase (MAPK),
P13K/Akt, JAK/STAT, sonic hedgehog (Shh), and NF-κB pathways are
the most common targeted dysregulated pathways found in GBM and
modulated by curcumin. Moreover, curcumin is highly lipophilic
and able to
Curcumin + Celecoxib: a synergistic and rationale
combination chemotherapy for breast cancer
European Review for Medical and Pharmacological Sciences | March
2021 This study is designed to explore the synergistic
inhibitory effect of the combination of curcumin and celecoxib
on the growth of human breast cancer cells. Our findings show
the prominent anti-proliferative effects of celecoxib and/or
curcumin on MDA-MB-231 cells, providing a rationale for further
detailed preclinical and potential clinical studies of this
combination for breast cancer therapy. Further, these computed
parameters suggested that curcumin possesses a high tendency to
act as an adjuvant drug with celecoxib in the treatment of
breast cancer.
Immune-Stimulatory Effects of Curcumin on the Tumor
Microenvironment in Head and Neck Squamous Cell Carcinoma
Cancers | March 2021 Curcumin is known to have
immune-modulatory and antitumor effects by interacting with more
than 30 different proteins. An important feature of curcumin is
the inhibition of nuclear factor kappa of activated B-cells
(NF-κB). Curcumin was more effective in inhibiting
PIC-dependent NF-κB activation and Treg attraction compared to
known NF-κB inhibitors BAY 11-7082 or caffeic acid phenethyl
ester. The presented results show, for the first time, the
immune-modulating effects of curcumin in HNSCC, with potent
inhibition of the Treg-attracting effects of PIC. Hence,
curcumin presents a promising drug in cancer therapy as a
supplement to already established treatments.
Curcumin with Promising Protection against Herpesvirus
Infections and Their Associated Inflammation
Microorganisms | March 2021 Curcumin is the key component of
the yellow pigment and the main bioactive molecule of turmeric.
Chemically, this compound belongs to the class of natural
phenolic compounds and has been broadly identified in diverse
Curcuma spp. In 1910, curcumin was characterized as a
symmetrical molecule of two 4-hydroxy-3-methoxyphenyl rings
fastened by α,β-unsaturated carbonyl groups, while its synthesis
was defined in 1913. Curcumin has been employed widely in the
traditional medicine systems of various countries and regions in
the world. Since the complete information about chemical
structure and synthesis is acquired, curcumin has been
extensively studied in various biological assays and has proven
to induce numerous pharmacological and beneficial impacts on
human health, including but not limited to the potential
treatment of various viral infections such as human
immunodeficiency virus, hepatitis B virus, hepatitis C virus,
influenza A virus, human papillomavirus, respiratory syncytial
virus, arboviruses, and noroviruses. Unlike the notable
antimicrobial actions, this biomolecule induces several
biological effects including but not limited to antioxidant,
anti-inflammatory, and anticancer properties. We reviewed the
curative properties of curcumin, a principal bioactive phenolic
compound of the spice turmeric, in regard to various human and
animal herpesvirus infections and inflammation connected with
these diseases. According to the reviewed studies, this paper
presents curcumin as a promising natural drug for the prevention
and treatment of herpesvirus infections and their associated
inflammatory diseases. In recent years, curcumin as a
nutraceutical agent has attracted major attention in many
research fields due to its great therapeutic potential against
various biological targets. We have comprehensively reviewed the
curative values of curcumin against numerous animal and human
herpesviruses along with the mechanisms by which this compound
induces antiherpetic properties, which were examined in vitro
and in vivo investigations. Based on several structure-activity
relationship studies, hydroxyl groups, carbonyl groups, and
phenyl rings of curcumin were observed to be accountable for the
induced anti-herpesvirus properties. In conclusion, this review
proposes curcumin as a potent and safe drug for the therapy of
herpesvirus infections as well as inflammation associated with
these infections.
Roles of Curcumin in Sensitising the Cisplatin
Effect on a Cancer Stem Cell-Like Population Derived from
Non-Small Cell Lung Cancer Cell Lines
Molecules | March 2021 Natural compounds such as curcumin
that contain high amounts of polyphenols can have a
chemosensitivity effect that sensitises CSCs to cytotoxic agents
such as cisplatin. Curcumin significantly suppressed
colonies formation by 50% and shrank the spheroids in cancer
stem ce subpopulations, indicating inhibition of their
self-renewal capability. This effect also was manifested by the
down-regulation of SOX2, NANOG, and KLF4. Curcumin also
regulated the niche of cancer stem cells by inhibiting
chemoresistance proteins, aldehyde dehydrogenase, metastasis,
angiogenesis, and proliferation of cancer-related proteins.
These results show the potential of using curcumin as a
therapeutic approach for targeting cancer stem cells
subpopulations in non-small cell lung cancer. Curcumin
(diferuloylmethane) is a naturally occurring polyphenol extract
that is found in turmeric. Curcumin has long been used as a
food, cosmetic, and traditional herbal molecules and
pathways without any associated toxicity or resistance. One of
the most compelling reasons for exploring curcumin is its sensitiser properties, which influence a diverse range of
molecular targets within cells.
Focus on Multi-targeted Role of Curcumin: a Boon in
Therapeutic Paradigm Environmental Science
and Pollution Research | March 2021 After thoroughly studying
several articles on combination therapy of curcumin through
authenticated book chapters, websites, research, and review
articles available at PubMed, ScienceDirect, etc., it has been
observed that multi-targeted curcumin possess enormous
anticancer potential and, with whatever drug it is given in
combination, has always resulted in enhanced effect with reduced
dose as well as side effects. It is also capable enough in
overcoming the problem of chemoresistance. Combining all the
factors together, we can conclude that combination therapy of
drugs with curcumin should be explored extensively
Efficacy of curcumin/turmeric on liver enzymes in
patients with non-alcoholic fatty liver disease
Integrative Medicine Research | March 2021 Meta-analysis of 4
randomized controlled trials including 228 subjects showed a
trend toward significant reduction of ALT blood concentrations suggests
that curcumin/turmeric might have a favorable effect on NAFLD in
higher dosage.
Curcumin suppresses tumor growth of
gemcitabine-resistant non-small cell lung cancer
Clinical and Translational Oncology | March 2021 Curcumin has
been reported to block cancer development by modulating multiple
signaling pathways. The results showed that curcumin suppressed
gemcitabine-resistant non-small cell lung cancer cell
proliferation and induced apoptosis. Curcumin upregulated the
expression of lncRNA-MEG3 and PTEN, and MEG3 overexpression
could increase the level of PTEN expression, while MEG3
knockdown decreased the level of PTEN expression in
gemcitabine-resistant non-small cell lung cancer cells. These
findings show the antitumor activity of curcumin for potential
clinical application in gemcitabine-resistant non-small cell
lung cancer treatment.
Curcumin anti‐tumor effects on endometrial cancer
with focus on its molecular targets Cancer
Cell International | March 2021 Curcumin is a phenolic
antioxidant extracted from turmeric, which is frequently used as
a spice and has a yellow color. The rhizome of the herb Curcuma
longa is the origin of turmeric that contains turmerin protein
as well as analogs of curcumin, demethoxycucumin, and
bisdemethoxycurcumin. 1,7-bis(4-hydroxy-3-
methoxyphenyl)-1,6-heptadiene-3,5-dione is the chemical name of
curcumin and C21H20O6 is its empirical formula. Since curcumin
and its two analogs have the same molecular and biological
characteristics, it is suggested that bisdemethoxycurcumin
converts to demethoxycucumin, which in turn, transforms into
curcumin. While curcumin plays a variety of beneficial roles,
studies on animals and humans have concluded that it is a safe
agent even at high doses. Curcumin acts as an anti-oxidative,
anti-microbial, anti-malarial, anti-HIV, and anti-angiogenic
agent. Furthermore, it can be used in the treatment of
inflammation, skin wounds, and neurodegenerative diseases.
Curcumin has complex chemistry and it is capable of targeting
some signaling pathways. Moreover, it can interact with several
intracellular and extracellular molecules. These features lead
to anti-tumor effects of curcumin on various cancer cells and is
useful at different stages, including prevention, treatment, and
controlling the symptoms of cancers. There are studies concerned
with the anti-tumor effects of curcumin in the treatment of EC.
Curcumin plays these roles by involving various targets, such as
signaling pathways, proteins, genes, and RNAs. Induction of
apoptosis, reducing inflammation, and inhibiting cell migration
are the results of curcumin treatment. Furthermore, there are
some miRNAs whose effects on EC have been identified and
curcumin has been observed to impact on these miRNAs but in
other cancers. Altogether, curcumin should be considered as a
therapeutic target in EC and its anti-tumor effects on this
cancer deserve further exploration.
The protective effects of curcumin in cerebral
ischemia and reperfusion injury through PKC-θ signaling
Cell Cycle | March 2021 Curcumin, a known antioxidant, has
been found to have neuroprotective effects. To determine the
protective mechanism of curcumin in ischemic stroke, oxygen and
glucose deprivation/reoxygenation (OGD/R) was used to treat PC12
cells to mimic the cerebral I/R cell model. Our results
demonstrated that curcumin could reverse the MCAO/R-induced
increase in Ca2+ concentration and blood–brain barrier (BBB)
disruption. Our study demonstrates the mechanisms by which
curcumin exhibited a protective function against cerebral I/R
through PKC-θ signaling by reducing BBB dysfunction.
Curcumin promotes cell cycle arrest and apoptosis of
acute myeloid leukemia cells by inactivating AKT
Oncology Reports | March 2021 Curcumin, a phytochemical from
rhizomes of the plant Curcuma longa, has been reported to exert
potential anticancer properties in various cancer types,
including acute myeloid leukemia (AML). The present study
demonstrated the anti-AML effect of curcumin both in vitro and
in vivo.
Curcumin repairs intestinal mucosal injury induced by 5-FU
chemotherapy for colon cancer National
Library of Medicine | March 2021 Curcumin maintained the
integrity of mucosal surface and villi structure of jejunum to a
large extent, and reduced pathological changes in a
dose-dependent manner. Meanwhile, curcumin could increase the
positive expression of occludin, claudin and ZO-1(P<0.05 or
P<0.01), repair intestinal barrier function, downregulate the
protein expression of IL-6, p-STAT3, vimentin and N-cadherin in
jejunum tissues(P<0.05 or P<0.01), and upregulate the
protein expression of E-cadherin(P<0.05). Therefore, curcumin
could repair the intestinal mucosal injury induced by 5-FU
chemotherapy for colon cancer, and the mechanism may be related
to the inhibition of IL-6/STAT3 signal and the inhibition of
epithelial-mesenchymal transition(EMT) process.
Effect of Curcumin, Exelon and their Combination on
Brain in Alzheimer’s Disease-Induced Rats Journal
of Advances in Medicine and Medical Research | March 2021
Curcumin is a natural product derived from Curcuma longa (more
commonly known as turmeric). Curcumin has anti-inflammation and
antioxidant activities, so it can decrease inflammation, amyloid
accumulation and oxidative stress which has ability to scavenge
free radicals. Also, it has protective potent from lipid
peroxidation, and scavenges nitric oxide (NO)-based radicals.
Curcumin has ability to inhibit formation of Aβ plaques and
lower soluble Aβ levels due to its metal chelation properties as
it binds to redox-active metal ions such as iron and copper.
These complexes may cause a net protective effect through
decreased Aβ aggregation. Curcumin is safe product which large
quantities can consumed without toxicity.
How curcumin affects hyperglycemia-induced optic
nerve damage: A short review Journal of
Chemical Neuroanatomy | March 2021 Curcumin is effective in
preventing the progression of diabetic complications and
improving complications. Curcumin has healing effects in optic
nerve damage with its anti-oxidant properties.
Effects of curcumin administration on Nesfatin-1 levels in
blood, brain and fat tissues of diabetic rats
European Review for Medical and Pharmacological Sciences | March
2021 Curcumin administration caused significant improvement
in fasting blood glucose levels. For the first time, we
found marked improvements in nesfatin-1 levels in blood, brain,
and fat tissues of type 2 DM rats. Thus, considering the crucial
role of nesfatin-1 in regulation of glucose metabolism, it is
logical to expect an interactive relationship between curcumin
and nesfatin-1.
Curcumin Supplementation Enhances Bone Marrow
Mesenchymal Stem Cells to Promote the Anabolism of Articular
Chondrocytes and Cartilage Repair Cell
Transplantation | March 2021 Curcumin displayed multiple
pharmacological activities including anti-inflammatory,
antioxidant, and anticancer, and has been employed in different
studies involving several pathologies such as cardiovascular
disease, depression, Alzheimer’s disease, epilepsy, Parkinson’s
disease, cancer, osteoporosis, rheumatic arthritis, and
osteoarthritis. It could inhibit the activation of nuclear
factor kappa-light-chain-enhancer of activated B cells (NF-κβ)
and synthesis of reactive oxygen species by reducing the
production of IL-1, IL-6, IL-8, and tumor necrosis factor α via
various pathways, and is emerged as an effective therapeutic
agent. For osteoarthritis treatment, curcumin supplementation
exhibited effects mainly based on its anti-inflammation,
antioxidant, and antiapoptosis potentials15. In clinical trials,
curcumin served as a natural product medicine displayed nearly
no side effects, thus making it a potential alternative to
NSAIDs and some other medications with known severe adverse
effects. In the current study, curcumin enhanced the BMSC
function for the proliferation and migration of articular
chondrocytes, and anabolic gene expression of ECM in articular
chondrocytes in vitro, and the regeneration of articular
cartilage in vivo. These results indicated potential clinical
application of curcumin cooperation with BMSCs in cartilage
repair for osteoarthritis treatment.
Curcumin for amyloidosis and lipid metabolism - a
novel insight eLife Shinshu University |
March 2021 Curcumin is a polyphenol compound produced by
plants of the Curcuma longa species and has been reported to
have many physiological activities, which include
anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid
properties. In previous studies, curcumin has been shown to
suppress the aggregation and cytotoxicity of many amyloid
proteins in vitro, such as amyloid ß (Aß), α-synuclein,
transthyretin, and prion protein, and has also been reported to
inhibit the deposition of Aß fibrils in a mouse model of
Alzheimer's disease. These findings demonstrate the novel
agonistic effect of curcumin on PPARα, which is an important
transcription factor for lipid metabolism, and may have
far-reaching significance for the treatment of amyloidosis and
other metabolic disorders. In addition, it has been regarded
that curcumin, as an agonist of PPARγ, exerts anti-inflammatory,
anti-cancer and antioxidant activities in the past. However,
this study demonstrates that curcumin is a PPARα/γ dual
activator and may affect expression levels of proteins involved
in amyloid deposition and other metabolism functions in a
complex manner. By focusing on the PPARα pathway, the group hope
to provide an opportunity to reconsider the mechanism of the
physiological effects of curcumin.
A protective effect of curcumin on cardiovascular
oxidative stress indicators in systemic inflammation induced by
lipopolysaccharide in rats Biochemistry and
Biophysics Reports | March 2021 Administration of curcumin
attenuated oxidative stress and inflammation in the serum, aorta
and heart tissues induced by lipopolysaccharide LPS.
Anti-inflammatory Effect of Curcumin on Human
Vitreous in Patients With Diabetic Retinopathy
Frontiers in Neurology | March 2021 Curcumin, a yellowish
non-flavonoid polyphenol that constitutes the main active
compound of Curcuma longa, is widely known for its antioxidant
and anti-inflammatory properties. Many studies have also
described its marked protective effect on retinal cells against
oxidative stress and inflammation. Curcumin is a well-known
bioactive molecule, largely employed in supplement formulation
due to its anti-inflammatory properties. Our study highlighted
the ability of curcumin to reduce cytokine levels in the
vitreous of diabetic patients. We also observed an additional
anti-inflammatory effect when curcumin was combined with
homotaurine and vitamin D3, suggesting that these molecules can
regulate the inflammatory network between the vitreous and
retina at different levels. This effect is confirmed by the gene
expression experiment which demonstrated that the combination of
curcumin, vitamin D3, and homotaurine down-regulate the cyclinD1
gene and the pro-inflammatory cytokine genes TNFα and IL6
expression.
Curcumin induces mitochondrial biogenesis by
increasing cAMP levels via PDE4A inhibition in skeletal muscle
British Journal of Nutrition | March 2021 Previous research
has suggested that curcumin potentially induces mitochondrial
biogenesis in skeletal muscle via increasing cAMP levels. The
present results suggest that curcumin increases cAMP levels via
inhibition of PDE4A phosphorylation, which induces mitochondrial
biogenesis through a cAMP/PKA/AMPK signalling pathway. Our data
also suggest the possibility that curcumin utilizes a regulatory
mechanism for mitochondrial biogenesis that is distinct from the
exercise-induced mechanism in skeletal muscle.
Catechin and curcumin interact with S protein of coronavirus
SARS-CoV2 and ACE2 of human cell membrane
Scientific Reports | February 2021 Several recent studies
have suggested that natural polyphenolic compounds like
catechins (GTCs; Green Tea Catechins) and curcumin
(diferuloylmethane; from turmeric) have antiviral activities
against a broad spectrum of viruses such as Human
Immunodeficiency Virus (HIV), Herpes Simplex Virus, Influenza
Virus, Hepatitis B and C Viruses (HBV and HCV respectively)14,
Adenovirus15 and Chikungunya virus (CHIKV). Diverse mechanisms
have been suggested to explain the antiviral activities of both
the polyphenolic compounds. Curcumin has been demonstrated as a
potent inhibitor of monophosphate dehydrogenase, a rate limiting
enzyme in the de novo synthesis of guanine nucleotide22.
Further, it has also been observed that GTCs and curcumin
inhibit the expression of ACE2
ASU study looks at how Curcumin supplements might help
post-COVID AZFamily.com | February 2021
Researchers at Arizona State University are conducting a study
into if whether or not two supplements can help reduce
inflammation after having COVID-19. An ASU grad student is part
of a research team, hoping to learn whether or not two
supplements reduce inflammation after COVID-19. "It can either
be Curcumin, which comes from the spice turmeric," said ASU Grad
Student Samantha Fessler. "...the other one is
Palmitoylethanolamide, and that comes from things like eggs and
peanut oil...using these supplements with the flu, they've been
proven to improve inflammation associated with the flu viral
infection and also post-recovery from other types of chronic
issues."
The potential role of curcumin in the prevention of COVID-19
Archives of Microbiology | February 2021 Due to the new
coronavirus’ unexplored nature, we shed light on curcumin for
its potential role against the disease. The current study showed
the use of curcumin against the coronavirus and its possible
role in developing medicine against it. Curcuma longa
produces turmeric (diferuloylmethane), named Indian saffron in
Europe, with its medicinal uses, including antiviral and
anti-inflammatory actions. It has shown that curcumin has its
inhibitory effects on the virus, including HIV, smallpox,
measles, and chickenpox are being among its target. In the
current study, we showed the possible use of curcumin in the
prevention of COVID-19 by targeting the virus replicase protein
Nsp9. Turmeric is the principle source of curcumin, and in India
it is used as an essential daily ingredient in the food
preparation while it has its own antiviral, antifungal,
antiallergic properties. Hence, it is preferred over other
medicinal compounds in the present study. As curcumin also
showed the antiviral properties, the interaction of curcumin and
Nsp9 may be useful in understanding the novel SARS Cov-2.
This supports the use of curcumin to reduce the pathological
consequences that emerged due to coronavirus infection. So, by
targeting the ssRNA of coronavirus at its initial replication
stage, through curcumin, when it enters the human is a matter of
immediate in-vivo research to possibly overcome the COVID-19 and
explore the inhibitory pathways of curcumin to prevent the new
coronavirus replication machinery in the human system.
Curcumin: reclaiming the lost ground against cancer resistancee
leydig testosterone Cancer Drug Resistance
| February 2021 Curcumin, a polyphenol, has a wide range of
biological properties such as anticancer, antibacterial,
antitubercular, cardioprotective and neuroprotective. Moreover,
the anti-proliferative activities of Curcumin have been widely
studied against several types of cancers due to its ability to
target multiple pathways in cancer. A large number of reported
studies and increasing interest of researchers have reinforced
the claim of curcumin being one of the most sought after natural
product in the fight against cancer. Curcumin, is a polyphenolic
compound of up to 5% present in turmeric. Curcumin as a
phytochemical has been widely explored for its therapeutic
potential through in vitro and in vivo investigations. It has
been shown to possess biological activity against a large
spectrum of physiological conditions, which include antioxidant,
chemo-protective, anti-diabetic and anti-proliferative activity
against cancer cells. Curcumin has shown commendable potential
during in vitro and in vivo studies against
vrious cancers. It has also been established through clinical
trials that curcumin does not show any adverse effect upto a
daily dose of 8 g to 12 g. The combinatorial treatment of
curcumin has been shown to sensitize the drug-resistant cancer
towards existing anticancer drugs and this aspect of
combinatorial treatment can be exploited to fully utilize the
curative potential of curcumin. In the near future, curcumin may
play an important role in chemotherapeutic regimes against
different types of cancers.
A Review of the Possible Effects of Curcumin in the
Treatment of COVID-19 Journal of Military
Medicine | February 2021 Curcumin is a natural polyphenolic
compound, which could be a potential treatment option for
patients with Covid-19. In this study, we review some of the
possible effects of curcumin, such as inhibiting virus entry
into the cell, inhibiting virus replication and viral protease,
as well as modulating some intracellular messenger pathways. To
comprehensive literature review, information from an internet
search of English language databases PubMed, Scopus, Web of
Science and ScienceDirect as well as Persian language databases
such as SID using related keywords based on MESH such as
COVID-19, SARS-COV-2 , Curcumin and curcuminoid between January
2020 and January 2021 were collected. This review provides some
possible effects of curcumin and its mechanisms for the
treatment of COVID-19.
Ten Days of Curcumin Supplementation Attenuates
Subjective Soreness and Maintains Muscular Power Following
Plyometric Exercise Journal of Dietary
Supplements | February 2021 Curcumin has become a popular
product used to decrease inflammation and enhance recovery from
exercise. Purpose: To determine the effects of curcumin
supplementation on delayed onset muscle soreness and muscle
power following plyometric exercise. Conclusion: These data
suggest curcumin reduces soreness and maintains muscular power
following plyometric exercise.
Curcumin: Natural Antimicrobial and Anti
Inflammatory Agent Journal of
Pharmaceutical Research International | February 2021 Various
studies, conducted as in vitro assays, have revealed different
therapeutic applications of curcumin due to its different
molecular mechanisms. Findings of the present in vitro study
confirmed consideration of curcumin as a natural antimicrobial
and anti-inflammatory agent. Test curcumin solutions
demonstrated strong antibacterial, antifungal and
anti-inflammatory activity. With an increase of curcumin
concentration antimicrobial and anti-inflammatory activity
increased, which implied that observed activity is dependent
upon the concentration of curcumin. In conclusion, the present
study emphasises the potential application of curcumin as a
natural antimicrobial and anti-inflammatory agent.
Oral
supplementation of curcumin for three months reduces p-CS plasma
levels in hemodialysis patients, suggesting a gut microbiota
modulation International
Urology and Nephrology | February 2021 Nutritional
strategies, such as bioactive compounds present in curcumin,
have been proposed as an option to modulate the gut microbiota
and decrease the production of uremic toxins such as indoxyl
sulfate (IS), p-cresyl sulfate (pCS) and indole-3 acetic acid
(IAA).
Effects of Curcumin on Glycemic Control and Lipid Profile in
Polycystic Ovary Syndrome
Nutrients | February 2021
Curcumin has been studied to adjunctly treat broad spectrum of
disease from type 2 diabetes mellitus to telogen effluvium. Curcumin
elicits antidiabetic effects via several mechanisms, including the
increase in glycolysis and glycogen synthesis and the decrease in
gluconeogenesis in the liver, as well as the increase in glucose
uptake, glycolysis, and glycogen synthesis in the skeletal muscle.
Curcumin has also been known to reduce plasma cholesterol and
triglyceride by increasing the activity of lipoprotein lipase and
through mechanisms which alter lipid and cholesterol gene
expression. In addition, the anti-inflammatory effects of curcumin
have been demonstrated to reduce the oxidative stress in patients
with PCOS. Previous literature reveals that curcumin significantly
improves fasting blood glucose and triglyceride in patients with
metabolic syndrome. In vivo study further demonstrates similar
effects in the PCOS model. Curcumin significantly improves fasting
glucose, fasting insulin, Homeostasis Model Assessment of Insulin
Resistance, and quantitative insulin sensitivity check index. It
also significantly improves high-density lipoprotein and total
cholesterol. Curcumin may improve glycemic control and lipid
metabolism in patients with PCOS and metabolic abnormality without
significant adverse effects. Curcumin may improve glycemic
control and lipid metabolism in patients with PCOS and metabolic
abnormality without significant adverse effects. Further studies are
advocated to investigate the potential effects of curcumin on
hyperandrogenism.
Curcumin promotes cell cycle arrest and apoptosis of
acute myeloid leukemia
Oncology Reports | February 2021
Curcumin is the main polyphenol component extracted from rhizomes of
the plant Curcuma longa, and its therapeutic benefit has been
demonstrated in various cancer types, including AML. However, the
underlying mechanism is complex and remains poorly understood, as
curcumin has multiple targets and is involved in various signaling
pathways. Afuresertib has been reported to exert antitumor effects
in ovarian cancer, malignant pleural mesothelioma and chronic
lymphocytic leukemia. However, to the best of our knowledge, its
role in AML has not been previously reported. The present study was
the first report that afuresertib could potentially be used for the
treatment of AML.In conclusion, the present study demonstrated that
curcumin decreased the survival and proliferation of AML cells in
vitro, as well as AML cell proliferation in hematopoietic tissue and
dissemination .
The Multifaced Actions of Curcumin in Pregnancy Outcome
Antioxidants | February 2021
Curcumin
(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), also
known as diferuloylmethane, is a polyphenolic yellow substance
coming from the rhizomes, the most commonly used plant part, of
Curcuma longa Linn (Zingiberaceae family). Curcumin structure is
similar to other bioactive non-volatile curcuminoids such as
dimethoxy-curcumin and bisdemethoxy-curcumin, differing only for the
number of methoxy groups on their aromatic rings. This plant has
been used since ancient times for both food and pharmaceutical
purposes, showing a variety of beneficial effects in the organism
reducing glycemia, hyperlipidemia, insulin resistance and
steatosis in non-alcoholic fatty liver disease (NAFLD). Moreover,
due to the cytotoxic effects of curcumin on tumor cells, this
compound showed good effects also as an anticancer agent inhibiting
tumor proliferation and inducing apoptosis in many cancer types
including breast, colon, lung and gastric cancer. Curcumin has
been extensively studied in various fields, showing a wide range of
action, including Antioxidant, anti-inflammatory, anti-toxicant,
anti-apoptotic, anti-diabetic and immunomodulatory actions,
demonstrated by in vitro studies and animal models, suggest the use
of this compound as a therapeutic agent in counteracting several
pregnancy complications. Inflammation, oxidative stress, Reactive
Oxygen Species (ROS) generation and apoptosis are common conditions
usually found in almost all of the pathological placental conditions
mentioned above; for this reason, curcumin could play a key role in
improving pregnancy outcome in these complications. To date, there
are many clinical trials studying the efficacy of curcumin in many
types of cancer that generally consider curcumin as well tolerated
and efficient adjuvant therapy ameliorating the response to
chemotherapy and radiotherapy reducing the side effects of these
therapies. Clinical effects of curcumin have also been shown in
other pathologies. In fact, curcumin improved the severity of
patients affected by non-alcoholic fatty liver diseases (NAFLD)
disease decreasing the serum concentrations of inflammatory
cytokines and chemokines such as TNF-α and MCP-1. Moreover, curcumin
intake in women with polycystic ovarian syndrome (PCOS)
significantly increased gene expression of PGC1α and activity of the
Gpx enzyme reducing oxidative stress. Another clinical trial showed
that curcumin was able to improve the symptoms in patients affected
by knee osteoarthritis. Beneficial curcumin effects were also found
in clinical trials focused on its role in body weight regulation,
finding a role for curcumin in reducing BMI and increasing weight
loss in addition to decreased serum levels of IL1β, IL-4 and VEGF.
Moreover, curcumin administration in two clinical trials showed that
curcumin could decrease glucose levels in patients with type 2
diabetes mellitus. Due to its multifaced role in regulating
different signaling and the encouraging data obtained in animal
models and in vitro studies, curcumin intake during pregnancy could
be beneficial in almost all the pregnancy complications mentioned in
this review.
Antioxidant Activity of Curcumin Protects against the
Radiation-Induced Micronuclei Formation
International Journal of Radiation Biology | February 2021
Curcumin when treated at a dose of 0.5 μg/mL attenuated micronuclei
formation after γ-irradiation by inhibiting the formation of
radiation-induced free radicals.
Curcumin significantly alleviated cognitive deficits
induced by cerebral ischemia.
Brain Research | February 2021
Curcumin ameliorates acute cerebral ischemia-induced cognitive
dysfunction in mice. Curcumin promotes hippocampal NSCs
proliferation and differentiation into neurons. Curcumin promotes
hippocampal neurogenesis through Wnt/β-catenin signaling pathway.
Recent Advances in the Synthesis and Development of Curcumin, its
Combinations, Formulations and Curcumin-like Compounds as
Antiinfective Agents
Current Medicinal Chemistry | February 2021
Curcumin, a redox-active natural product, has for centuries been
used in Asian traditional medicine for the treatment of various
diseases. It is known for possessing multiple biological and
pharmacological activities. Curcumin has been investigated
extensively over the years for its anti-inflammatory, anticancer,
antiparasitic, antiviral and antibacterial activities, and no
toxicity is associated with the compound. Despite its potency and
safety profile, curcumin is still in clinical trials for the
treatment of diseases, such as tuberculosis, acquired
immunodeficiency syndrome (AIDS), Crohn's disease, colorectal cancer
and multiple myeloma, among many others, as it is yet to be
qualified as a therapeutic agent.
The effect of curcumin on serum copper, zinc, and
zinc/copper ratio in patients with β-thalassemia intermedia: a
randomized double-blind clinical trial
Annals of Hematology | February 2021
Due to its significant therapeutic effects, curcumin has led many
studies to focus on curcumin. Curcumin might exert a net
protective effect on copper toxicity in thalassemia intermedia
patients. The investigation also implicated that curcumin represents
an approach to regulating zinc homeostasis and may be useful as a
complementary treatment of patients with thalassemia intermedia,
especially in patients with zinc deficiency or low serum zinc/copper
ratio.
Curcumin promotes AApoAII amyloidosis and peroxisome proliferation
in mice by activating the PPARα signaling pathway
Elife | February 2021
Curcumin is a polyphenol compound that exhibits multiple
physiological activities. Curcumin, a polyphenol compound, is
extracted from the rhizome of Curcuma longa and has a long history
of use in traditional medicines. In in vitro experiments,
curcumin has been shown to suppress the aggregation and cytotoxicity
of Aβ, αSyn, islet amyloid precursor protein (IAPP), ATTR and prion
protein (PrP). In 2001, the first evidence of the efficacy of
curcumin against Aβ amyloidosis in a transgenic model mice was
reported. Curcumin was found to suppress amyloid deposition in a
mouse model of Alzheimer's disease and improve memory function. It
was subsequently demonstrated that the amount of amyloid present in
TTR-and tau-transgenic mice were reduced by curcumin
supplementation. Curcumin is a compound with multiple physiological
activities, which includ eanti-oxidation, anti-inflammatory,
anti-cancer, lipid metabolism regulation and anti-amyloid
properties.
Curcumin and
Metabolic Diseases: The Role of Gut Microbiota
Nutrients | January 2021
Turmeric, also known as Curcuma longa L. belongs to
Zingiberaceae (or ginger family) and is a golden-colored spice.
Curcumin
((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)
is the principle curcuminoid of turmeric used in traditional
medicine to cure various kinds of malady, as well as being a food
additive and coloring agent in Asian cuisines and in beverage
industries. Hewlings and Kalman stated the beneficial effects of
curcumin in the treatment of chronic diseases, such as
gastrointestinal, neurological disorders, cardiovascular disease,
diabetes, and several types of cancer. Enzymes of the large
intestine metabolise curcumin, and it is carried out in two phases.
In phase-1 metabolism, it yields three metabolites,
1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
(tetrahydrocurcumin),
5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone
(hexahydrocurcumin), and
1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol
(octahydrocurcumin) under reduction. After that, curcumin and its
metabolites subject to conjugation through phase-II metabolism to
yield sulfate and glucuronide O-conjugated metabolites. Curcumin
metabolites have properties and potency similar to curcumin and
exhibit the same physiological and pharmacological properties. It
has been stated that curcumin and gut microbiota have bidirectional
interactions such as gut microbiota regulation by curcumin and
biotransformation of curcumin by gut microbiota. Carmody et al
reported that the biological properties of curcumin depend on the
activity of metabolites produced by gut microbiota digestion. The
curcumin metabolic pathways by GM include reduction, methylation,
demethoxylation, hydroxylation, and acetylation, and the main
products are 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
(tetrahydrocurcumin), 3-(4-Hydroxy-3-methoxyphenyl)propanoic acid
(dihydroferulic acid), and 1-(4-hydroxy-3-methoxyphenyl)-2-propanol.
Furthermore, curcumin can also be metabolized by Pichia pastoris
into four major metabolites, include
1,7-bis(4-hydroxy-3methoxyphenyl) heptan-3,5-diol,
5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl) heptan-3-one,
5-hydroxy-1,7-bis(4-hydroxyphenyl) heptane-3-one, and
5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)
heptan-3-one [101,103]. Many GM, such as E. coli, E. fergusonii
(ATCC 35469) Blautia sp. (mrg-pmf1), Bifidobacterium (Bifidobacteria
longum BB536, Bifidobacteria pseudocatenulaum G4), Lactobacillus
(Lactobacillus casei and Lactobacillus acidophilus), Enterococcus
faecalis JCM 5803, Pichia anomala, and Bacillus megateriumdcmb-002,
are found biologically relevant in the biotransformation and
degradation of curcumin.
Curcumin, a traditional spice component, can hold the promise
against COVID-19?
European Journal of Pharmacology | January 2021
Curcumin, known for its pharmacological abilities especially as an
anti-inflammatory agent, can be hypothesized as a potential
candidate in the therapeutic regimen. COVID-19 has an assorted range
of pathophysiological consequences, including pulmonary damage,
elevated inflammatory response, coagulopathy, and multi-organ
damage. This review summarizes the several evidences for the
pharmacological benefits of curcumin in COVID-19-associated clinical
manifestations. Curcumin can be appraised to hinder cellular entry,
replication of SARS-CoV-2, and to prevent and repair
COVID-19-associated damage of pneumocytes, renal cells,
cardiomyocytes, hematopoietic stem cells, etc. The modulation and
protective effect of curcumin on cytokine storm-related disorders
are also discussed. Collectively, this review provides grounds for
its clinical evaluation in the therapeutic management of SARS-CoV-2
infection.
The combination of bromelain and curcumin as an
immune-boosting nutraceutical in the prevention of severe COVID-19
Metabolism | January 2021
The antiviral actions of curcumin against multiple viruses
(influenza and hepatitis viruses, herpes viruses, human papilloma
virus, human immunodeficiency virus, severe acute respiratory
syndrome coronavirus and other coronaviruses), bacteria and fungi
have been established by experimental evidence. Remarkably, recent
evidence from in silico studies has demonstrated that curcumin
prevents SARS-CoV-2 entry into cells by blocking the viral binding
sites and the cell ligands (spike protein, ACE-2 receptors and
basigin), downregulating trans-membrane serine protease 2
(TMPRSS-2), and by interfering with viral replication through the
interaction with various viral proteins Curcumin (diferuloylmethane)
is a natural phenol found in turmeric (Curcuma longa), a member of
the ginger family of plants. Curcumin modulates inflammation
preventing the subsequent cytokine storm by inhibiting multiple
transcription factors such as nuclear factor kappa B (NF-κB) and
signal transducer and activator of transcription 3 (STAT-3), and
downregulating the proinflammatory cytokines, as this has been
demonstrated in human macrophages after influenza virus infection.
Additionally, curcumin inhibits ACE modulating angiotensin II
synthesis and downregulating inflammation, while it also promotes
fibrinolysis and the anticoagulation process. Notably, bromelain
substantially increases the absorption of curcumin after oral
administration. To the best of our knowledge, this is the first
report highlighting the significance of bromelain and, most
importantly, the potential preventive value of the synergistic
effects of bromelain and curcumin against severe COVID-19.
The potential anti-cancer properties of curcumin in
liver cancer
In Vivo | January 2021
Curcumin is a polyphenol that exerts a variety of pharmacological
activities and plays an anti-cancer role in many cancer cells.
Curcumin increased the expression of the GSDME N-terminus and
proteins involved in pyrolysis, promoted HspG2 cell pyrolysis and
increased intracellular ROS levels. Moreover, inhibition of the
production of intracellular ROS with n-acetylcysteine (NAC) improved
the degree of apoptosis and pyrolysis induced by curcumin. Curcumin
induces HspG2 cell death by increasing apoptosis and pyroptosis, and
ROS play a key role in this process. This study improves our
understanding of the potential anti-cancer properties of curcumin in
liver cancer.
The role of curcumin, a potent constituent of turmeric
in pleiotropic health beneficial effects
Journal of Biologically Active Products from Nature | January 2021
Curcumin (1,6- heptadiene- 3,5 - dione- 1,7 - bis
(4-hydroxy-3-methoxyphenyl) - (1E,6E) or diferuloylmethane),
isolated from Curcuma longa, is a highly promising natural compound
that has several health benefits. Supplementation of curcumin
provided significant (p < 0.05) protection against HgCl2 induced
alterations by ameliorating the levels of ROS, PCO, SA, and -SH in
erythrocytes membrane and plasma. Thus, the curcumin protects
against HgCl2 induced oxidative stress. It also provides an insight
into the role of curcumin, a potent constituent of turmeric in
pleiotropic health beneficial effects.
Curcumin, the primary active ingredient in turmeric, reportedly
exerts potent antifibrotic effects
Basic & Clinical Pharmacology & Toxicology | January
2021
These results indicate that curcumin is a promising treatment agent
for RIF, and its antifibrotic effects may be mediated by the
inhibition of NLRP3 inflammasome activity through the regulation of
autophagy and protection of mitochondrial function in UUO rats.
Curcumin Suppresses Cell Growth
Life Sciences | January 2021
Curcumin induced Ac-p53 and p21 to suppress cell proliferation.
Curcumin increased p-Akt and attenuated fluoride-mediated apoptosis
and DNA damage. Curcumin suppressed fluoride-induced p-p21 and
increased p21 in the nuclear fraction.
Dichloroacetic acid-induced dysfunction in rat
hippocampus and the protective effect of curcumin
Metabolic Brain Disease | January 2021
Various doses of curcumin attenuated DCAA-induced oxidative stress,
inflammation response and impaired synaptic plasticity, while
elevating cAMP, PKA, p-CREB, BDNF, PSD-95, SYP levels. Thus,
curcumin could activate the cAMP-PKA-CREB signaling pathway,
conferring neuroprotection against DCAA-induced neurotoxicity.
Curcumin protects radiation-induced liver damage in rats
through the NF-κB signaling pathway
Complementary Medicine and Therapies | January 2021
Curcumin has been demonstrated to exert anti-oxidant, anti-fibrotic,
anti-inflammatory, and anti-cancer activities. Our study highlights
that curcumin treatment reduces the liver damage caused by radiation
through the inhibition of the NF-κB pathway.
Curcumin, as a good all-natural drug for the treatment
of IBD, possesses good prospects in clinical application
Molecular Medicine Reports | January 2021
Curcumin is an all-natural compound extracted from plants. It has
many biological activities including anti-inflammatory,
anti-infective and immune-regulating, and it protects the intestinal
mucosa and repairs the function of intestinal tissue. Other similar
studies have shown that in the DSS-induced colitis model, curcumin
is found to significantly improve intestinal inflammation, repair
the intestinal mucosa and inhibit the expression of TNF-α and
p38MAPK. Curcumin itself has anti-inflammatory and anti-infective
effects. At the same time, curcumin can reduce and inhibit the
exudation of neutrophils and macrophages, regulate intestinal immune
disorders, reduce intestinal endothelial cell swelling and increase
permeability, which further reduces intestinal inflammation.
Curcumin can significantly decrease the DAI and SI of the mice with
colitis. Curcumin, as a good all-natural drug for the treatment of
IBD, possesses good prospects in clinical application.
Effect of Curcumin on Triple-Negative Breast Cancer
AIP Conference Proceedings | January 2021
Curcumin has been reported to efficiently inhibit cancer cell lines,
including MCF7, K562, HeLa,and 4T1. Previous study of curcumin on
4T1 breast cancer cells showed that the IC50 values were 93,14 μM.
The main mechanisms of action by which curcumin exhibits its
040024-2 unique anti-cancer activity include inducing apoptosis and
inhibiting proliferation, invasion, and metastasis of tumors by
suppressing a variety of cellular signaling pathways. Several
research on various breast cancer cell lines demonstrate the
anti-cancer activity of curcumin through the inhibition of NF-κB
activity. Curcumin, the yellow pigment isolated from turmeric,
has been reported to suppress NF-κB. Several studies reported that
curcumin inhibits NF-κB through inhibition of IKK phosphorylation
and inhibition of translocation to the nucleus. Curcumin selectively
inhibits NF-κB p105 mRNA expression on 4T1 breast cancer cell line
by interacting with the backbone of Ile residue in RH domain region.
This study highlights the potency of curcumin to be developed as a
chemotherapeutic targeted NF-κB for triple-negative breast cancer in
the future.
Curcumin has a certain antagonized effect on cardiac
arrhythmia and has potential application prospects
Frontiers in Physiology | January 2021
Curcumin is a natural yellow polyphenolic substance, the main active
alkaloid extracted from the rhizome of turmeric, a rhizomatous
herbaceous perennial plant belonging to the family Zingiberaceae,
which has been used as an antiseptic and antipyretic folk medicine
for centuries. Previous researches have shown that curcumin has
extensive pharmacological activities and has been put into clinical
practice. Increasing evidence showed that curcumin has a protective
effect against cardiovascular disease. For instance, curcumin can
prevent the development of heart failure by inhibiting p300 histone
acetyltransferase activity, antagonized sodium fluoride intoxication
in rat heart, prevented isoprenaline (ISO)-induced cardiac
hypertrophy, and can have a protective effect against the myocardial
infarction injury. In addition, curcumin was reported to prevent the
QTc prolongation in ISO-induced myocardial infarction.
Curcumin is also a multi-ion channel blocker that inhibits ICa.L and
IKr and preferentially blocks INa.L, shortens APD, suppresses EADs
and DADs at the cellular level, prevents I/R-induced arrhythmia at
the organ level, and may have potential antiarrhythmic property.
Curcumin can prevent the occurrence of arrhythmias after
reperfusion, which is beneficial for the recovery of isolated heart
suffering from I/R injury.
New evidence for the potential anti-inflammatory and
cardiovascular protective effects of curcumin
Evidence-Based Complementary and Alternative Medicine | January 2021
Curcumin is the most active component of spice turmeric (also called
curry powder), mainly found in turmeric roots (Curcuma longa L.). It
has long been studied for its antioxidant, anti-inflammatory,
antimutagenic, antimicrobial, and anticancer properties. In the
recent years, curcumin has been extensively investigated for its
therapeutic value. Its anti-inflammatory effect which is equivalent
to that of steroidal and nonsteroidal drugs, e.g., indomethacin and
phenylbutazone, is one of the most studied properties. In various
inflammation-related chronic illnesses such as cardiovascular
disease, cancer, diabetes, and obesity, curcumin has shown good
therapeutic effects. The present study shows that curcumin
suppresses aldosterone-induced CRP generation in VSMCs by
interfering with the ROS-ERK1/2 signaling pathway. These results
reveal a mechanism through which curcumin represses inflammation and
confers cardiovascular protection. Our findings further confirm the
anti-inflammatory and cardiovascular protective effects of curcumin
and suggest its potential clinical use in cardiovascular
inflammation.
Curcumin may be an attractive natural candidate for further
investigation and development in the quest for Parkinson's disease
therapeutics
International Journal of Molecular Sciences | January 2021
The polyphenolic ingredient of dietary turmeric (Curcuma longa),
curcumin, has attracted attention due to its multiple benefits to
patients with various diseases including Parkinson's disease.
Several studies have demonstrated that curcumin treatment
significantly inhibits the toxin-induced loss of dopaminergic
neurons in both cultured cells and animal models. Curcumin was found
to exert neuroprotective effects mediating anti-oxidant,
anti-inflammatory, and anti-apoptotic properties and improve
neurological functions in various animal models of Parkinson's
disease. Our results demonstrated that intragastric curcumin
treatment (200 mg/kg) significantly improved the abnormal motor
behavior and offered neuroprotection against the reduction of
dopaminergic neurons, as determined by tyrosine hydroxylase (TH)
immunoreactivity in the substantia nigra and caudoputamen. In
conclusion, this study demonstrates that curcumin has a
neuroprotective effect in a 6-hydroxydopmine (6-OHDA) rat model of
PD via an α7-nAChR-mediated mechanism. The findings of the present
study demonstrate that curcumin improves the survival of TH striatal
fibers and neurons in SNpc and diminishes abnormal turning behavior
in a 6-OHDA-induced rat model of PD. In the present study,
abrogation of the protective effects of curcumin by pretreatment
with MLA, an α7-nAChR-selective antagonist, clearly demonstrates
that neuroprotective effects of curcumin are mediated by α7-nAChRs.
Our findings clearly demonstrate that α7-nAChRs may be an attractive
therapeutic target for PD and curcumin appears to be the first agent
of natural origin to modulate α7-nAChRs in PD. Integrating our
earlier observation that curcumin acts as a type II PAM of α7-nAChRs
and potentiates receptor function by significantly decreasing
desensitization, it is apparent that the PAM action of curcumin on
α7-nAChRs exerts beneficial effects in mediating neuroprotective
effects. Time-tested safety and neuroprotective efficacy of curcumin
and preliminary clinical success of agents targeting nicotinic
receptors in Parkinson's disease.
Curcumin and NAC may be effective against noise-induced
hearing loss
Indian Journal of Otolaryngology and Head & Neck Surgery |
January 2021
We investigated the effectiveness of N-acetyl cysteine (NAC) and
curcumin, which have known antioxidant and anti-inflammatory
effects, in reducing acoustic trauma. There was a statistically
significant difference in the third measurements in both groups 2
and 3, possibly due to curcumin and NAC treatment. This study showed
that curcumin and NAC may be effective against noise-induced hearing
loss.
Curcumin exhibits beneficial effect on bone fracture
healing
Medical Science Monitor | January 2021
Curcumin has been used for a very long time in traditional medicine
because of several pharmacological properties. Multiple properties
of curcumin include its role as an anti-inflammatory, antioxidant,
and anti-fibrotic agent. Additionally, studies have shown tumor
growth inhibitory effect and myocardial injury protecting property
of curcumin. Although studies on the use of curcumin in bone trauma
treatment are limited, reports suggest that curcumin may have a
positive effect in bone remodeling. The current study investigated
curcumin for bone trauma treatment in a rat model and evaluated the
related mechanism. Curcumin activates autophagy and inhibits mTOR
activation in bone tissues of rats with trauma. The curcumin
promoted myeloid-derived suppressor cell (MDSC) proliferation and
increased expansion of MDSCs in a rat model of trauma. Therefore,
curcumin may have beneficial effect in patients with bone trauma and
should be evaluated further for development of treatment.
A novel application of curcumin in tumor therapy
Archives of Biochemistry and Biophysics | January 2021
Curcumin promotes cancer-associated fibroblasts apoptosis via
ROS-mediated endoplasmic reticulum stress. Curcumin is a natural
polyphenol derived from turmeric, which has been shown to inhibit
the growth of many types of tumor. We found that curcumin
induced the apoptosis and cell cycle arrest of CAFs, which is mainly
caused by the ROS-mediated endoplasmic reticulum stress pathway. Our
study suggests that curcumin selectively inhibits prostate-CAFs by
inducing apoptosis and cell cycle arrest in G2-M phase, indicating a
novel application of curcumin in tumor therapy.
Curcumin may be an alternate to antimicrobial drugs for
the therapeutic management of endometritis
Molecular Biology Reports | January 2021
Curcumin inhibited the basal and LTA+LPS induced production of PGE2
and upregulation of PIC production. It was apparent that LPS, but
not LTA, is a potent stimulator of PGE2 from the bubaline
endometrial stromal cells. Curcumin downregulated the expression of
LPS and/or LTA induced PICs and PGE2 and may be an alternate to
antimicrobial drugs for the therapeutic management of endometritis.
Curcumin represents a promising therapy for Diabetes
mellitus induced cognitive impairments and memory deficits
Neurobiology of Disease | January 2021
Curcumin, derived from the rhizome of Curcuma longa Linn, is a
bright yellow spice that shows strong anti-inflammatory,
anti-oxidant, and anti-tumor activities.ibiting neuroinflammation.
We demonstrated that curcumin attenuated DM/CCH-induced cognitive
defcits and hippocampal neuronal damage in rats, and that its
underlying mechanisms were associated with inhibiting
neuroinflammation, regulating the TREM2/TLR4/NF-κB pathway,
suppressing excessive apoptosis, and mitigating NLRP3-dependent
pyroptosis. These findings suggest that curcumin may be useful as a
pharmacological strategy for ameliorating Diabetes mellitus
/CCH-induced memory deficits.
Curcumin exhibited renoprotective, antioxidant,
anti-inflammatory properties, especially curcumin exerted the most
pronounced effect as an anti-inflammatory and anti-apoptotic
reflecting its powerful effect against bacteria and sepsis-induced
kidney injury
Future Journal of Pharmaceutical Sciences | January 2021
Curcumin a polyphenol extracted from turmeric gained interest as a
potentially safe and inexpensive treatment for kidney diseases.
Inflammatory markers were greatly reduced by both curcumin and
propolis, only curcumin pretreatment attenuated NF-kB activation in
kidney tissue of septic rat.
The protective effect of curcumin on ACR-intoxicated
brains
BMC Pharmacology and Toxicology | January 2021
Curcumin is well known for its classic and strong anti-oxidative and
anti-inflammatory activities. As the most active constituent in
turmeric, a common spice, with a strong safety record, curcumin has
been considered to be a potential natural neuroprotective agent
under limelight. Based on its known antioxidant, anti-inflammatory
and anti-apoptosis activities, curcumin has been shown to protect
the neurons against cerebral ischemia-reperfusion injurye
neuroprotective effect of curcumin in an ACR model of neurotoxicity
in an insect species, Drosophila melanogaster. A recently published
study reported that curcumin would exert a protective effect against
ACR-induced spatial memory impairment in rats. The phenolic
structure in curcumin confers electron-capturing properties, which
destabilize ROS, explaining the well-accepted antioxidant effects.
Curcumin alleviated the augmented production of MDA and the
reduction of antioxidant capacity induced by ACR, thus might play a
role in the detoxification of reactive oxygen species generated by
ACR. Curcumin could improve the ACR-induced neuroinflammation,
which was in accord with its proven anti-inflammatory property.
Curcumin: Could This Compound Be Useful in Pregnancy and
Pregnancy-Related Complications?
Nutrients | January 2021
Curcumin, the main polyphenol contained in turmeric root (Curcuma
longa), has played a significant role in medicine for centuries.
The pleiotropic and multi-targeting actions of curcumin have made it
very attractive as a health-promoting compound. In spite of the
beneficial effects observed in various chronic diseases
anti-inflammatory, antioxidant, antitoxicant, neuroprotective,
immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive,
and antidiabetic properties of curcumin appear to be encouraging,
not only for the management of pregnancy-related disorders,
including gestational diabetes mellitus (GDM), preeclampsia (PE),
depression, preterm birth, and fetal growth disorders but also to
contrast damage induced by natural and chemical toxic agents.
Curcumin, a compound extracted from the rhizome of Curcuma longa,
has been extensively studied in light of a wide range of properties,
including anti-inflammatory, antioxidant, anti-toxicant,
antiapoptotic, immunomodulatory, neuroprotective, hepatoprotective,
antiangiogenic, anti-hypertensive, and antidiabetic activities,
emerging as a candidate therapeutic agent for several diseases.
Curcumin, also called diferuloylmethane, is a lipophilic polyphenol
extracted from the rhizome of Curcuma Longa (commonly known as
turmeric). It has been widely used in traditional Indian and Chinese
medicine for thousands of years. The pharmacological effects of
turmeric have been attributed mainly to curcuminoids, comprising
curcumin and two related compounds, demethoxycurcumin and
bisdemethoxycurcumin, which are contained in commercial curcumin.
Curcumin is a potent anti-inflammatory and antioxidant agent that
exerts a myriad of biological activities by influencing multiple
signaling pathways. Curcumin is able to interact with a large number
of molecular and cellular targets and regulates gene expression also
by modulating epigenetic modifications (i.e., DNA methylation,
histone modification, and microRNA expression). This compound, by
mutually interacting with intestinal microflora
Curcumin extract eased pain, stiffness and physical
function in those with osteoarthritis of the knee
New York Times | December 2020 Turmeric comes from the root
of a plant in the ginger family, Curcuma longa, and contains a
chemical compound, curcumin, that has long been used in
traditional Chinese and Indian medicine. In a 12-week
randomized, double-blind, placebo-controlled trial, researchers
assigned 70 people with symptomatic knee osteoarthritis to take
either two capsules a day of a Curcuma longa extract or two
capsules of an identical-looking placebo. They found that pain,
stiffness and physical function all improved significantly more
in those who took the curcumin extract than in those who used
the placebo.
Neonatal curcumin treatment restores hippocampal
neurogenesis and improves autism-related behaviors in a mouse
model of autism
Psychopharmacology |
December 2020 Curcumin has been indicated to be
neuroprotective against neurological and psychological
disorders. Neonatal curcumin treatment improved autism-related
symptoms in BTBR mice, enhancing sociability, reducing
repetitive behaviors, and ameliorating cognitive impairments.
Furthermore, the suppression of hippocampal neurogenesis in BTBR
mice was greatly rescued after neonatal curcumin treatment,
leading to an increase in neurogenic processes and an increase
in NPC proliferation concomitant with an expansion of the NPC
pool on P8, and NPC differentiation towards the neuronal lineage
was promoted in the DG of BTBR mice on P24. Our findings suggest
that neonatal curcumin treatment elicits a therapeutic response
through the restoration of hippocampal neurogenesis in BTBR mice
and thus may represent a promising novel pharmacological
strategy for ASD treatment.
Curcumin
cooperates with anticancer drugs
The
International Journal of Biochemistry & Cell Biology | December
2020 Curcumin inhibit Lactate-induced onset of
chemoresistance through modulation of HCAR-1. Curcumin
modulates Chromatin condensation and acidification of
extracellular milieu of cancer cells.
Can Turmeric Help With
Knee Arthritis San Diego Orthobiologics | December 2020 Turmeric, a spice
from South Asia derived from the Curcuma longa root, has been
used as a medicine for nearly 4000 years. Recent studies have
shown that turmeric may help to relieve joint pain caused by
arthritis because the active ingredient, curcumin, is now known
to have anti-inflammatory properties. Curcumin has been shown to
have similar efficacy to diclofenac, a non-steroidal
anti-inflammatory drug, with fewer side effects. Similar
improvements in pain severity and function were seen with
curcumin and diclofenac in a randomized, controlled clinical
study of 139 patients with knee osteoarthritis. Nineteen
patients in the diclofenac group (and none in the curcumin
group) required anti-ulcer medications at 28 day followup.
Curcumin has also been shown to have a strong antioxidant
capacity. In a randomized double-blind placebo-controlled trial,
patients with mild-to-moderate knee osteoarthritis were given
the curcuminoid and were compared to a group that received a
placebo for 6 weeks. Researchers measured the levels of enzymes
known to influence inflammation (e.g. superoxide dismutase (SOD)
and malondialdehyde (MDA)). The treatment group showed
significant changes in these enzymes suggesting that short-term
supplementation with curcumin decreases oxidative stress.
5 Good Things About
Turmeric MD News Daily | December 2020 A report about turmeric
indicates that study in the European Review for Medical and
Pharmacological Studies, Frontiers in Pharmacology, and
Endocrine, Metabolic & Immune Disorders Drug Targets associate
curcumin with weight loss and reduction in body mass index or
BMI. Healthy cooking expert and registered dietitian Patricia
Bannan said, while increasing our turmeric intake alone is not a
great tactic in losing weight, it may contribute to the
mitigation of inflammation linked to obesity and offer a slight
boost in fat burning. Curcumin may help protect from
inflammation, and inflammation may help in fighting depression.
A 2019 meta-analysis of 10 studies of curcumin and depression
published in Critical Reviews in Food Science and Nutrition
proposed that it could alleviate depression and anxiety
symptoms. Experts say the most available study specifies that
curcumin may help lessen the depression symptoms in individuals
who are already using an antidepressant. Previous studies on
animals propose that there might be a link between the
inflammation-calming action of curcumin in turmeric and cancer.
Specifically, Bannan said, curcumin is believed "to have
antioxidant properties." Meaning, it may reduce both swelling
and inflammation. Nevertheless, research on animals does not
always translate humans. Research for curcumin continues, as
well as its effect on cancer in people. A study finds people
living in India have lower rates of developing Alzheimer's
disease than those living in the United States and Europe. The
reasons for the difference, the study authors said, are complex
and possibly because of several different factors. Typically,
turmeric is used in Ayurveda, a holistic healing mechanism that
originated in India thousands of years back and remains famous
to date. Turmeric is also prominent in Indian cuisine, bringing
out the question of whether it is possible that this spice can
contribute to the prevention or delay of onset of Alzheimer's.
The jury, according to the study, is still out. However, one
theory presents, curcumin may contribute to the inhibition of
plaques that other studies have linked to "neuron impairment in
the brain. Based on a report by the Centers for Disease
Prevention and Control, more than 100 million adults in the US
have developed either prediabetes or diabetes. A study on
curcumin, which the Journal of Nutrition & Intermediary
Metabolism published, proposes that it can function as a
"hypoglycemic agent," reducing and helping regulate blood sugar
levels in people who have type 2 diabetes, CDC said.
Anti-inflammatory effects of oral supplementation with curcumin:
a systematic review and meta-analysis of randomized controlled
trials Nutrition Reviews | December 2020 Chronic inflammation is a major contributor to the development
of noncommunicable diseases. Curcumin, a bioactive polyphenol
from turmeric, is a well-known anti-inflammatory agent in
preclinical research. Clinical evidence remains inconclusive
because of discrepancies regarding optimal dosage, duration, and
formulation of curcumin. These findings provide evidence for the
anti-inflammatory effects of curcumin and support further
investigation to confirm dose, duration, and formulation to
optimize anti-inflammatory effects in humans with chronic
inflammation.
Quinacrine and curcumin synergistically increased breast cancer
stem cells death
Cancer Biology and
Therapeutic Oncology | December 2020 Curcumin and QC
synergistically inhibited the proliferation, migration and
invasion of CSCs enriched side population (SP) cells of
cigarette smoke condensate induced breast epithelial transformed
(MCF-10A-Tr) generated metastatic cells. Curcumin + QC
combination increased the DNA damage and inhibited the DNA
repair pathways in SP cells. Uptake of QC increased in Curcumin
pre-treated SP cells and this combination inhibited the ABCG2
activity by the reduction of ATP hydrolysis in cells. In vitro
DNA binding reconstitution system suggests that QC specifically
binds to DNA and caused DNA damage inside the cell. Decreased
level of ABCG2, representative cell survival and DNA repair
proteins were noted after Curcumin + QC treatment in SP cells.
Longevity-Promoting Herb Well and Good
| December 2020 In 2018, Dr. Small authored a small
double-blind study showing that taking two 90 mg curcumin
supplements daily for 18 months improved memory and attention in
older adults with mild memory problems. “We did find it has a
significant effect…compared to placebo,” says Dr. Small, who is
currently expanding the research to a much larger sample size
across the U.S. While he’s not sure exactly how curcumin works
to boost brain health, “my best guess is it’s the reduction in
inflammation,” he says. Robinette points out that turmeric has
been called a “natural immunomodulator,” or a substance that
helps keep the immune system in check by boosting immunity when
you need it and tamping it down to prevent excess inflammation
involved in many chronic conditions. Some research suggests that
turmeric could potentially even play a role in preventing and
treating cancer, cardiovascular disease, metabolic conditions,
neurological disease, and skin diseases. Although it certainly
doesn’t hurt to enjoy more foods with turmeric, you’ll need to
pop a curcumin supplement to get the full health benefits of the
spice. “For therapeutic purposes, you want to take higher
doses,” says Robinette. Try to take the supplement when you eat
your meals, preferably with fat (like fatty fish or nuts) to
increase the bioavailability of curcumin.
Antitumor effects of curcumin in pediatric
rhabdomyosarcoma International Journal of
Oncology | December 2020 Curcumin (CUR) is a promising drug in
complementary oncology with few side effects but proven efficacy
in various adult oncological entities. The present study
analyzed the effects of curcumin on pediatric (RMS) cell lines
in vitro. Curcumin decreased cell viability in all assessed RMS
cell lines in a concentration‑dependent manner with IC50=14‑20
µM. Curcumin enhanced the effects of the cytotoxic drugs VCR or
DAC, and led to reduced migration and increased cell apoptosis.
In combination with PDT, curcumin decreased the cell viability
in minute quantities with up to a 10‑fold lower IC50 than
without PDT. Curcumin effectively inhibited the malignant
properties of pediatric RMS cells and should be focused on as a
useful additional agent in standard chemotherapy of RMS in
children.
Curcumin in antidepressant treatments Basic & Clinical Pharmacology & Toxicology, December 2020 Curcumin, a natural compound derived from the herb Curcuma
longa, exhibits a wide range of pharmacological properties and
has been considered a potent antidepressant drug with diverse
mechanisms including monoaminergic imbalances (associated with
serotonin, dopamine, noradrenaline and glutamate), effect on
neurotransmitters, neuroprogression, the
hypothalamic‐pituitary‐adrenal (HPA) axis disturbances,
dysregulated inflammation and immune pathways, oxidative and
nitrosative stress, and mitochondrial disturbances. In this
review, multiple potential mechanisms of curcumin for treating
depression demonstrated in either animal or human studies are
summarized.
Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated
Inflammation in Human Tenocytes in Vitro Journal of Biological Chemistry, December 2020 Inflammatory
processes play essential roles in the pathogenesis of tendinitis
and tendinopathy. Results demonstrate, for the first time,
a potential role for curcumin in treating tendon inflammation.
Curcumin in Depression: Potential Mechanisms of
Action and Current Evidence
Frontiers in
Psychiatry | March 2021 Curcumin is the main active component
in the spice turmeric that has been used for centuries in
Ayurvedic medicine to treat a variety of conditions, including
anxiety and depressive disorders. In the past decades, curcumin
has drawn researchers' attention and displays a broad range of
properties that seem relevant to depression pathophysiology.
Curcumin has displayed, in a number of studies, a potency in
modulating neurotransmitter concentrations, inflammatory
pathways, excitotoxicity, neuroplasticity,
hypothalamic–pituitary–adrenal disturbances, insulin resistance,
oxidative and nitrosative stress, and endocannabinoid system,
all of which can be involved in MDD pathophysiology. To date, a
handful of clinical trials have been published and suggest a
benefit of curcumin in major depressive disorder. With evidence
that is progressively growing, curcumin appears as a promising
alternative option in the management of major depressive
disorder. Turmeric (Curcuma longa) is a yellow spice,
part of the ginger family (Zingiberacear). It has been
empirically used for centuries in Ayurvedic and traditional
Chinese medicine in a wide variety of diseases and conditions.
Research conducted in the last half century has revealed that
the active compounds of turmeric were curcuminoids, which are
polyphenolic pigments that give turmeric its yellowish color.
Curcumin is the primary curcuminoid and main active component in
turmeric and the compound for which most studies have been done.
In the past decades, there has been a surge of interest in
curcumin as evidence about its efficacy in a wide variety of
diseases is growing, including cardiovascular, autoimmune, and
neurodegenerative diseases as well as diabetes and cancers.
Thus, curcumin displays a broad range of properties that are
relevant in the pathophysiology of depression. It has been
demonstrated to possess an antidepressant activity in various
animal models as well as in clinical trials. A dozen randomized
controlled clinical trials have indeed been conducted,
altogether suggesting that curcumin may be effective as a
treatment (or adjunct treatment) of depression via multiple
mechanisms of action.
Anticancer properties of curcumin: a novel natural inhibitor of
rDNA transcription
Cell Cycle | November
2020 Curcumin treatment impairs the
assembly of the RNA polymerase I preinitiation complex at rDNA
promoters and represses rDNA promoter activity, which leads to
the decrease of rRNA synthesis. In addition, curcumin treatment
stimulates autophagosome formation and promotes autophagic
degradation in cells. Mechanistically, curcumin inactivates the
mechanistic target of rapamycin complex 1 (mTORC1), the upstream
regulator of rDNA transcription and autophagy induction, by
inhibiting mTOR lysosomal localization. Functionally, curcumin
treatment inhibits protein synthesis, cell growth and cell
proliferation. Taken together, these findings identify curcumin
as an effective inhibitor of rDNA transcription and provide
novel mechanisms for the anticancer properties of curcumin.
Reduce Your Lifetime Risk of Breast Cancer The Beet | November 2020 Curcumin lowers inflammation, which
can lower the risk of breast cancer. Curcumin, the main active
ingredient in turmeric, is known for relieving inflammation and
pain but also for having an effect on lowering the risk of
breast cancer. A study found "curcumin has chemopreventive and
antitumoral activities against some aggressive and recurrent
cancers," the study said. Another study found curcumin not only
stops tumor growth but also prevents malignant cancers from
spreading: The "anticancer effect" of curcumin relates to the
fact that it appears to half "cell cycle and proliferation," as
well as "cancer spread and angiogenesis," the study says, which
is how the body supplies new blood vessels to a tumor.
Curcumin
against Prostate Cancer: Current Evidence Biomolecules | November 2020 The available
in vitro studies
have shown that curcumin is able to inhibit viability,
proliferation, survival, migration/invasion, and adhesion of
various human prostate cancer cells. Curcumin inhibited both
androgen-sensitive and -insensitive prostate cancer cells by
targeting a number of signaling cascades responsible for
regulating cellular function. The antiproliferative,
antisurvival, and antimigratory effects of curcumin in prostate
cancer cells may be due to the inhibition of the Akt/mTOR,
Ras/MAPK signaling pathways, decreased NF-κB activation,
enhanced proapoptoptic caspase and PARP cleavage, and the
inhibition of members of the antiapoptotic Bcl-2 family of
proteins. Curcumin was also able to induce cell-cycle arrest and
enhance autophagy in various prostate cancer cell lines. The
available in vivo studies have shown that curcumin
administration is able to inhibit the growth/volume, formation,
development, proliferation, and angiogenesis of prostate cancer
tumors while promoting apoptosis. These effects were observed in
mice xenografted with both androgen-sensitive and insensitive
prostate cancer cells. Curcumin’s inhibition of prostate tumor
growth and progression may be due to its inhibition of Akt
expression/activation, decreased NF-κB activation, inhibition of
the anti-apoptotic proteins Bcl-2 and Bcl-xL, increased
expression of the proapoptotic proteins Bax and Bak, and
enhanced PARP and caspase expression. These findings from in
vivo studies are in agreement with those from the in vitro
studies. The downregulation of cell proliferation, paired with
the enhanced activity of programmed cell death both in vitro
and in vivo, render curcumin an ideal candidate for the development
of novel anticancer pharmaceutical agents providing fewer
detrimental effects due to its low toxicity.
Metabolites of curcumin and their therapeutic
effects Cell | November 2020 Curcumin, a
secondary metabolite from the turmeric plant is one of the most
promising natural products, which has been studied extensively
for decades. It has demonstrated several pharmacological
activities in vitro and in vivo. Several diverse therapeutic
effects have shown to be exhibited by reduced metabolites of
curcumin such as antioxidant, anti-cancerous, anti-inflammatory
and immunoregulatory activities. Curcumin is a natural
polyphenolic compound which forms a majorcomponent of rhizomes
from dietary spice turmeric (Curcuma longaa plant belongs to
Zingiberaceae family. It is commonly used as a flavouring agent
in various foods and also as a traditional medicinal agent. In
several studies, curcumin have shown a diverse range of
pharmacological effects like, anti-cancer, anti-oxidation,
anti-inflammatory, anti-bacterial activities, free radical
scavenging and anti-depression. Owing to these pharmacological
effects, curcumin has therapeutic potential over a variety of
human diseases such as cancer, cardiovascular disease, diabetes,
arthritis, Alzheimer's disease, AIDS, neurological diseases, and
Crohn's disease. The importance of curcumin can be estimated by
the fact that thirty-seven cases of clinical trials of curcumin
were completed by December 2017 and two cases FDA (Food and Drug
administration) clinical phase 4 trials were completed.
Evaluation of the effect of curcumin on pneumonia: A systematic
review of preclinical studies Phytotherapy
Research | November 2020 Curcumin is a natural phytochemical
with anti‐inflammatory and anti‐neoplastic characteristics. Our
results demonstrated that curcumin ameliorated the
pneumonia‐induced lung injury, mainly through a reduction of the
activity and infiltration of neutrophils and the inhibition of
inflammatory response in mouse models. Curcumin ameliorates the
severity of pneumonia through a reduction in neutrophil
infiltration and by amelioration of the exaggerated immune
response in preclinical pneumonia models.
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's
Disease: A Systematic Review
Journal of
Medicinal Food | November 2020 The
results of the randomized clinical trials (RCTs) showed
promising results with the use of curcumin in the therapeutic
approach of both UC and CD patients. Some meta-analyses show
controversial results, possibly due to the presence of bias in
the included studies. The actions of curcumin are achieved by
several mechanisms, such as reducing the expression of
interleukin (IL)-1, IL-6, IL-12, and tumor necrosis factor-α.
Moreover, it reduces the levels of reactive oxygen species, such
as superoxide anions and malondialdehyde.
Evaluation
of Cognitive Performance following Curcumin Supplementation in
Middle-Aged and Older Adults with Overweight or Obesity The Journal of Nutrition | November 2020 Curcumin improved
CVR in a working memory test and, in males only, performance of
a verbal memory test compared with placebo.
Chemotherapeutic efficacy of curcumin and
resveratrol against cancer: Chemoprevention, chemoprotection,
drug synergism and clinical pharmacokinetics Seminars in Cancer Biology | November 2020 Curcumin and
resveratrol modulate the apoptosis and autophagy mediated cell
death pathway for chemoprevention. Curcumin and
resveratrol reduce cytotoxicity and exhibit chemo-protection
during chemotherapy. Drug synergism and advanced drug
delivery systems of curcumin and resveratrol enhances the
anticancer efficacy. Enhanced pharmacokinetics and
pharmacodynamics are responsible for better pre-clinical and
clinical application.
COVID‐19: A Case for Inhibiting NLRP3 Inflammasome, Suppression
of Inflammation with Curcumin?
Nordic
Pharmacological Society | November 2020 Curcumin is the
effective ingredient of turmeric, sometimes used as a painkiller
in traditional medicine. Curcumin regulates several molecules in
the intracellular signal transduction pathways involved in
inflammation, including IBB, NF‐kBERK1,2, AP‐1, TGF‐β, TXNIP,
STAT3, PPARγ, JAK2‐STAT3, NLRP3, p38MAPK, Nrf2, Notch‐1, AMPK,
TLR‐4 and MyD‐88. Due to anti‐inflammatory and anti‐inflammasome
properties without any special side effects, curcumin can
potentially play a role in the treatment of COVID‐19 infection
along with other drug regimens.
Curcumin Suppresses Tumorigenesis via Promoting SLC1A5-mediated
Ferroptosis in Breast Cancer
Surgical
Oncology | November 2020 Curcumin treatment significantly
suppressed breast cancer cell viability in a dose-dependent
manner. Moreover, curcumin triggered ferroptosis by enhancing
the levels of lipid ROS, lipid peroxidation end-product MDA
accumulation, and intracellular Fe2+. Mechanistically, curcumin
administration impeded tumor growth via upregulating solute
carrier family 1 member 5 (SLC1A5)-mediated ferroptosis in
breast cancer. In vivo experiments showed that curcumin could
effectively hamper the growth of tumors without noticeable side
effects. Conclusion: We demonstrated that curcumin exhibits
anti-tumorigenesis activity in breast cancer by promoting
SLC1A5-mediated ferroptosis, providing a potential therapeutic
agent for the treatment of breast cancer.
Curcumin Inhibits the Migration and Invasion of Non-Small-Cell
Lung Cancer Cells
Technology in Cancer
Research & Treatment | November 2020 Curcumin inhibited
sE-cad expression and reversed EMT induced by radiation.
Furthermore, curcumin suppressed sE-cad-enhanced A549 and A549R
cell migration and invasion. Curcumin inhibited MMP9 expression,
and silencing MMP9 suppressed sE-cad expression. Taken together,
we found a nonclassic EMT phenomenon induced by radiation.
Curcumin inhibits NSCLC migration and invasion by suppressing
radiation-induced EMT and sE-cad expression by decreasing MMP9
expression.
Can concomitant use of zinc and curcumin with other
immunity‐boosting nutraceuticals be the arsenal against
COVID‐19?
Phytotherapy Research | November
2020 Curcumin is a natural bioactive polyphenolic compound
isolated from the dried powder of Curcuma longa rhizomes,
commonly known as turmeric (Haldi in Hindi), and widely used
worldwide for cooking. Ayurveda mentioned the use of turmeric
for numerous therapeutic purposes like blood coagulation to
immune stimulation. An array of systemic antioxidant properties
has been attributed to curcumin‐containing nutraceuticals. For
example, it exerts an anti‐inflammatory action in arthritis and
inflammatory bowel diseases, reduces lipid levels in
cardiovascular diseases, and addresses oxidative stress in skin
disorders. Curcumin has an established track record as an
antiviral agent against several viruses like Influenza Type A,
Hepatitis A, Zika, HIV, etc. The mode of action of curcumin
includes—inhibition of viral entry into cells, suppression of
viral replication, stimulation of interferons (IFNs) and other
cytokines, and inhibition of viral protein expression. In silico
studies have also revealed that curcumin binds directly with the
receptor‐binding domain of the viral spike protein (involved in
host cell binding) and the cognate host cell receptor,
angiotensin‐converting enzyme‐2 (serves as a medium of viral
entry), of SARS‐CoV‐2 virus. Moreover, curcumin has been
reported to inhibit the release and suppress numerous cytokines
like IL‐1β, IL‐6, IL8, TNFα, MCP‐1, etc. When investigated in
various viral infections set‐up, the mode of cytokine
suppression by curcumin can be correlated with clinical
improvement in conditions associated with cytokine storm.
Following the suggested interaction with these key components of
the viral lifecycle and immune system, it is apparent that
curcumin could prevent the COVID‐19 infection. Moreover, in
recent years, blood coagulation properties of curcumin (by
inhibiting platelet aggregation, cyclooxygenase pathway, and
blocking of calcium signaling) have been utilized in designing
various materials and devices. As the SARS‐CoV‐2 coronavirus
infection can be associated with a disseminated intravascular
coagulopathy, hence curcumin can be an effective agent against
this pathological condition.
Turmeric, Curcumin, and Curcuminoids: A Dermatologic Review
PracticalDermatology.com | November 2020
Research has shown that curcumin, one of the active compounds of
turmeric, exhibits anti-inflammatory, antimicrobial,
antioxidant, anti-nociceptive, and antineoplastic properties.
Specifically, curcumin has been shown to potentially play a role
in type 2 diabetes mellitus by reducing lipid levels, in
metabolic syndrome by increasing insulin sensitivity and
production, in cardiac diseases by lowering C reactive protein,
and even in major depressive disorder via its anti-inflammatory
effects. Currently, it is being studied as a possible treatment
for Alzheimer’s disease. Curcumin is thought to downregulate
inflammatory targets, such as lipoxygenase, cycloxygenase-2, and
inducible nitric oxide synthase. It has also been shown to
inhibit many inflammatory cytokines, including TNF, IL-1, 2, 6,
8, and 12. Moreover, curcumin has been hypothesized to suppress
NF-KB, which is a transcription factor that controls
cycloxygenase-2 and inducible nitric oxide synthase and
regulates cellular proliferation. These findings make curcumin a
suitable candidate for treating skin conditions that are
characterized by derangement of the inflammatory response.
The potential therapeutic effects of curcumin on
pregnancy complications: Novel insights into reproductive
medicine International Union of
Biochemistry and Molecular Biology | November 2020 Curcumin,
the main polyphenolic compound derived from Curcuma longa, is
mainly known by its anti‐inflammatory and antioxidant
properties. There are in vitro and in vivo reports revealing the
preventive and ameliorating effects of curcumin against
pregnancy complications. Here, we aimed to seek mechanisms
underlying the modulatory effects of curcumin on dysregulated
inflammatory and oxidative responses in various pregnancy
complications.
Effect of topical curcumin on the healing of major oral mucosal
ulceration Eurasian Journal of Biosciences
| November 2020 Curcumin was a turmeric extract, its
multifaceted biological effects such as, anti-inflammatory,
anti-oxidant, anti-carcinogenic and anti-infectious effects.
Results: The present study showed that the curcumin treatment
reduce mucosal ulcer area from the 3rd day till 7th day and
improved ulcer healing at 14th day by activation of epithelial
cell, inhibit inflammatory cells, enhance endothelial cells and
promote fibroblast cells.
Effectiveness of Curcuma longa Extract for the Treatment of
Symptoms and Effusion–Synovitis of Knee Osteoarthritis
Annals of Internal Medicine | November 2020 Curcumin was more effective than placebo for knee pain but did
not affect knee effusion–synovitis or cartilage composition.
Therapeutic Effects of Curcumin Against Colorectal Cancer
Phytochemicals Targeting Tumor in Gastrointestinal
Cancer, October 2020 Curcumin is a product of the plant,
Curcuma longa, which exhibits anti-inflammatory,
anti-infectious, and anticancer activities. A wide variety of
evidences from numerous studies demonstrated that curcumin
prevents carcinogenesis, modulates signaling, inhibits
angiogenesis and other critical aspects linked to cancer cell
survival and proliferation, and induces chemopreventive and
anticancer activity against colorectal cancer. Curcumin also
showed improved efficacy of chemotherapeutic agents in
combination studies.
Antitumoral Effects of Curcumin (Curcuma longa L.)
on Neuroblastoma Cell Lines Complementary
Medicine Research, October 2020 Overall survival of high-risk
neuroblastoma patients is still poor, emphasizing the need for
novel therapeutic options. There is evidence for anti-cancer
properties of the herbal substances thymoquinone and curcumin.
Overall, lower IC50 values could be calculated for curcumin
(3.75–7.42 µM) than for thymoquinone (5.16–16.3 µM). Decreased
proliferation and increased apoptosis rates were observed under
treatment. Conclusions: Both substances showed anti-tumoral
properties on neuroblastoma cell lines and should be further
investigated as therapeutic agents.
Curcumin reverses diabetic nephropathy in streptozotocin-induced
diabetes The Journal of Nutritional
Biochemistry, October 2020 Curcumin protects against
T1DM-induced nephropathy. Mechanism of protection involves
inhibition of oxidative stress, inflammation, and fibrosis.
Curcumin seems to act by inhibiting PKC-induced activation of
Psch66.
Curcumin an aid to Cardiovascular diseases Financial Express, October 2020 Curcumin plays a very
important role in protecting your heart from these
cardiovascular diseases because the antioxidants in curcumin
have been shown to attenuate adriamycin-induced cardiotoxicity
and may prevent diabetic cardiovascular complications. The
anti-thrombotic, anti-proliferative, and anti-inflammatory
effects of curcumin and the effect of curcumin in decreasing the
serum cholesterol level may protect against the pathological
changes occurring with atherosclerosis.
Health Benefits Of Turmeric
Maine News
Online, October 2020 Turmeric is a readily available and
natural remedy for chronic inflammation. It contains curcumin,
which has excellent anti-inflammatory properties. The curcumin
even makes turmeric more effective than most anti-inflammatory
drugs. And besides, it is natural, accessible, pocket friendly,
and has no known side effects. What curcumin does is to suppress
the molecules responsible for the inflammation. By so doing, it
will protect you from chronic diseases.The curcumin in turmeric,
according to research, can lower oxidative stress. It serves as
antioxidants and has the power to stimulate the body’s
antioxidant enzymes. Consequently, this strengthens one’s immune
system.What makes curcumin beneficial for your heart health is
improving the endothelium (blood vessels’ lining) function.
Curcumin’s anti-inflammatory and antioxidant functions also make
it useful for maintaining your heart health.Studies have
identified curcumin, which is present in turmeric, as a potent
herb in cancer treatment. The studies also indicated that
curcumin’s effect is the same in all cancer types. What curcumin
does is that it fights cancer at the molecular level. It
prevents the growth, spread, and development of the disease in
the body. According to a study conducted by the MD Anderson
Cancer Center, researchers discovered that curcumin inhibits
melanoma cells’ growth and even cause tumor cells to eliminate
themselves. Curcumin can increase BDNF levels in the brain. With
this action, it can encourage the reversal or delay of
brain-related decline or diseases. Studies have been conducted
to confirm curcumin’s potency in arthritis treatment, and the
outcome showed great promise. In one of the studies, curcumin
proved to be more potent than most anti-inflammatory medication
used in treating rheumatoid arthritis. As documented in another
study, curcumin’s use led to improvements in various symptoms
most arthritis patients had. Turmeric’s effect on mental health
has been well-documented. One of its constituents, curcumin,
proves useful in the fight against depression. In one study
involving 60 participants who had depression, the participants
were divided into three groups. The first group was given an
antidepressant; the second group had a gram of curcumin, while
the third had both the antidepressant and curcumin. After six
weeks, curcumin’s effect was similar to the antidepressant.
Turmeric’s curcumin has shown promising antiviral properties. It
can take down specific viruses, as reported by the Microbiology
Society. In a study conducted, curcumin prevented TGEV
(Transmissible gastroenteritis virus) from infecting cells. In
high dosage, curcumin was able to eliminate the virus particles.
Effect of Curcumin on Testis in Mice with Ehrlich Ascites Tumor
New Trends in Medicine Sciences, October
2020 Findings clearly suggested that antioxidant parameters
(except CAT and GPx) had higher value in animal models treated
with 25 and 50 mg curcumin groups associated to tumor control
group. There was a statistically noteworthy variance between the
groups in all parameters. Antitumor effect of curcumin on
ascites tumor cells produced by EAT cells evidenced with
histopathological while antioxidant and anti-inflammatory
biochemical parameters evidenced with biochemical parameters.
An
Exploratory Analysis of Changes in Mental Wellbeing Following
Curcumin Supplementation in Middle-Aged and Older Adults
Nutrients, October 2020 Curcumin has previously
been shown to enhance mood in non-depressed older adults. In a
16 week randomized, double-blind, placebo-controlled, 2 × 2
factorial design trial, we supplemented overweight or obese
non-depressed adults (50–80 years) with curcumin (160 mg/day),
fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic
acid/day), or a combination of both. Curcumin improved vigour (p
= 0.044) compared to placebo and reduced SMCs compared to no
curcumin treatment (p = 0.038). This exploratory analysis
indicates that regular supplementation with either curcumin (or
fish oil limited to APOE4 non-carriers) has the potential to
improve some aspects of mental wellbeing in association with
better quality of life.
Curcumin administration and the effects on
psychological status and markers of inflammation and oxidative
damage in patients with type 2 diabetes and coronary heart
disease Clinical Nutrition and Metabolism,
October 2020 Curcumin intake significantly decreased
Pittsburgh Sleep Quality Index (PSQI) (β -1.27; 95% CI, -2.27,
-0.31; P=0.01) compared to the placebo group. Curcumin intake
caused a significant reduction in malondialdehyde (MDA) (β -0.20
μmol/L; 95% CI, -0.36, -0.04; P=0.01), significant increase in
total antioxidant capacity (TAC) (β 75.82 mmol/L; 95% CI, 3.400,
148.25; P=0.04) and glutathione (GSH) levels (β 63.48 μmol/L;
95% CI, 26.58, 100.37; P=0.001) when compared with the placebo.
Additionally, curcumin intake upregulated peroxisome
proliferator-activated receptor gamma (PPAR-γ) (P=0.01).
Conclusion: Curcumin intake for 12 weeks in patients with T2DM
and CHD had beneficial effects on PSQI, TAC, GSH, MDA values,
and gene expression of PPAR-γ.
Interaction between Gut Microbiota and Curcumin: A New Key of
Understanding for the Health Effects of Curcumin
Nutrients, October 2020
Curcumin, one of the major curcuminoids contained in the
rhizome of Curcuma longa (turmeric), is a lipophilic polyphenol
that has been used for centuries as an essential tool of
traditional medicine in Asia. Curcumin has received considerable
attention in the last years for its pharmacological activities.
Due to the presence of conjugated double bonds in its chemical
structure, this polyphenol serves as an effective electron donor
to counteract the production of reactive oxygen species (ROS) in
many redox reactions, acting as a potent antioxidant. In
addition, it has other important biological functions, such as
anti-inflammatory, antitumor, antimicrobial, and antiviral ones.
Different studies highlighted that curcumin, like other dietary
polyphenols, counteracts the effects of toxic damage in
different tissues and, in addition, it is able to interfere with
key cancer-associated signaling pathways by directly targeting
proteins or regulating gene expression. According to its
biological activities, curcumin has been proposed as a potential
treatment for many diseases, among which are gastrointestinal,
cardiovascular, and neurological disorders, diabetes, and
several types of cancer . Curcumin, a lipophilic polyphenol
contained in the rhizome of Curcuma longa (turmeric), has been
used for centuries in traditional Asian medicine, and nowadays
it is widely used in food as dietary spice worldwide. It has
received considerable attention for its pharmacological
activities, which appear to act primarily through
anti-inflammatory and antioxidant mechanisms. For this reason,
it has been proposed as a tool for the management of many
diseases, among which are gastrointestinal and neurological
diseases, diabetes, and several types of cancer. The observed high
concentrations of curcumin in the GI tract after oral
administration can lead to two major effects: an altered gut
microbiota and the modulation of intestinal functions. The
scientific literatures were searched for in vivo, experimental
and clinical studies, and human randomized controlled trials,
reporting results on the interaction between curcumin and gut
microbiota and vice versa.
Cardioprotective effect of curcumin against diabetic
cardiomyopathy in type 1 diabetes mellitus Naunyn-Schmiedeberg's Archives of Pharmacology, October 2020
Treatment with curcumin markedly reduced serum cardiac injury
markers and lipid profile markers in diabetic animals.
Additionally, curcumin treatment mitigated oxidative stress and
fibrosis in diabetic rats as evident from the significant
suppression in myocardial lipid peroxidation and tumor growth
factor beta 1 (TGF-β1) level, with concomitant significant
elevation in total antioxidant capacity (TAC) and improvement in
histopathological architecture of heart tissue. Curcumin
treatment protocol accomplished its cardioprotective effect by
depressing cardiac CaMKII/NF-κB signaling accompanied by
enhancement in PPAR-γ expression. Conclusively, these findings
demonstrated the therapeutic potential of curcumin regimen in
alleviating DCM in T1DM through modulation of CaMKII and PPAR-γ
expression.
Curcumin Allosterically Inhibits the Dengue NS2B-NS3
Protease by Disrupting Its Active Conformation ACS Omega, October 2020 Flaviviruses including dengue virus
and Zika virus encode a unique two-component NS2B-NS3 protease
essential for maturation/infectivity, thus representing a key
target for designing antiflavivirus drugs. Here, for the first
time, by NMR and molecular docking, we reveal that curcumin
allosterically inhibits the dengue protease by binding to a
cavity with no overlap with the active site. Moreover, as
curcumin has been used as a food additive for thousands of years
in many counties, it can be directly utilized to fight the
flaviviral infections and as a promising starting for further
design of potent allosteric inhibitors.
Fight COVID-19 depression with immunity booster: Curcumin for
psychoneuroimmunomodulation
Asian Journal
of Psychiatry, September 2020 Curcumin is the bioactive
component of turmeric, one of the key ingredients of prescribed
ayurvedic interventions and spices used in meal preparation in
South-East Asia. Known for immunoboosting aptitude, curcumin can
alleviate the COVID-19 associated ill-effects including cytokine
storm. Alleviating psychological stress by curcumin will also
adjunct its immunoboosting potential. Curcumin can avert the
anxiety and the stress-driven manifestation of depression
through modulation of the monoaminergic troupe (dopamine,
glutamate, serotonin, and noradrenaline) by curcumin. Curcumin,
through Nuclear factor erythroid-2-related factor 2 (Nrf2), can
prevent such stress and improve antioxidant Glutathione (GSH)
production. Major depression disorders (MDD) associate with
disturbances in the hypothalamus-pituitary-adrenal (HPA) axis.
Curcumin can correct the HPA disturbances and avert elevated
glucocorticoids, their receptor as well as inducers (cortisone
and adrenocorticotropic hormone). Along with evident
immunomodulator, turmeric component, especially curcumin exhibit
antidepressant activity, and improve cognitive/mood function.
The potential of curcumin containing nutraceutical in COVID-19
has been predicted both through PNI modulation and 'meaning
response'. Moreover, curcumin can alleviate the overt
inflammatory consequences, even those associated with COVID-19,
and thus will improve physical well-being. Curcumin ameliorates
inflammation and its regulators like STAT3 in a variety of
disorders including COVID-19. Curcumin can improve the
hematopoietic differentiation of immune cells; and thus can
mitigate ill effects even through reinstating immune cells
number. Moreover, curcumin improves neurogenesis and hippocampus
functioning. Curcumin-mediated immunoboosting, antidepressant
effect, and neurogenesis may also improve the mood function and
ward off anxiety/stress in a covert manner. Nutraceuticals like
curcumin can be a promising option as immunity boosters and
antidepressants for PNI response. Traditionally used in
medicinal practices, clinical safety of turmeric (and curcumin)
is well assessed. Moreover, relative low case fatality rates
(CFR) of COVID-19 in South-Asian countries like India are being
recorded which can be governed by several factors, including
diet and traditional medicine practice. Although the novel
nature of the COVID-19 pandemic makes the efficacy of previously
known drugs anonymous, ascertaining the true potential of
curcumin through preclinical and clinical investigations will be
of immense benefit. Immunoboosting as well as improvement of
psychological well-being by curcumin; thus can be hypothesized
to facilitate improvement in infected patients, health care
workers as well as distantly affected individuals.
Pyschoneuroimmunomodulation by curcumin, even as an adjuvant,
can aid the fight against COVID-19.
Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin
Sensitivity in Resistant Colorectal Cancer Cells Evidence-Based Complementary and Alternative Medicine, September
2020 Previous studies have confirmed that curcumin displays
antitumor effects on a variety of cancers, including colorectal
tumors. In addition, curcumin has been shown to prevent tumor
resistance. Mehdi et al. found that curcumin combined with
5-fluorouracil can improve the chemotherapeutic effects of 5FU
on colorectal cancer resistant strains by reducing mismatch
repair ability. Curcumin can reverse the drug resistance
of cancer cells. Curcumin was found to inhibit ERCC1 through its
ability to modulate miR-409-3p. Curcumin can overcome L-OHP
resistance in colorectal cancer cells through its effects on
miR-409-3p mediated ERCC1 expression.
Curcumin (a constituent of turmeric): New treatment option
against COVID‐19
Food Science & Nutrition,
September 2020 We describe the possible therapeutic effects
of curcumin and its molecular mechanism against coronavirus‐19.
Curcumin, as an active constituent of Curcuma longa (turmeric),
has been studied in several experimental and clinical trial
studies. Curcumin has some useful clinical effects such as
antiviral, antinociceptive, anti‐inflammatory, antipyretic, and
antifatigue effects that could be effective to manage the
symptoms of the infected patient with COVID‐19. Curcumin, as a
potential agent, could be considered to treat COVID‐19.
Curcumin, as an active constituent of rhizomes of C. longa
(turmeric), is a hydrophobic polyphenol (Figure 1) (Akbar et
al., 2018; Soleimani, Sahebkar, & Hosseinzadeh, 2018). Curcumin
is used as a spice in foods and for different purposes such as
cosmetic and pharmaceutical industries in world (Hosseini &
Hosseinzadeh, 2018). Curcumin has several pharmacological
effects such as antioxidant, anticancer, antibacterial,
antiviral, and antidiabetic effects (Fan et al., 2015;
Moghadamtousi et al., 2014; Zhu et al., 2017), as well as
anti‐inflammatory activity (Cheng, Yang, Hu, Zhu, & Liu, 2018).
As the potential role of curcumin to treat many inflammatory
disorders, at the first step we will describe all effects of
curcumin that may be useful to treat COVID‐19, and then, we
explain the possible molecular mechanisms of it. We considered
all articles of curcumin—human and animal studies—that could be
effective to treat or rescue COVID‐19‐infected patients. PubMed
and Web of Science were used as databases. As the importance of
the subject, some selected papers were in the press. The
keywords used for the search were as follows: coronavirus‐19,
COVID‐19, SARS‐CoV‐2, curcumin, Curcuma longa, turmeric,
curcumin and antiviral, curcumin and anti‐inflammatory, curcumin
and antipyretic, curcumin and lung, curcumin and acute lung
injury, curcumin and fatigue, curcumin and antioxidant, curcumin
and ARDS, curcumin and bradykinin, curcumin and fibrosis,
curcumin and Interleukin‐6 (IL‐6), curcumin and tumor necrosis
factor‐alpha (TNF‐α), curcumin and NF‐κB, curcumin and Toll‐like
receptors (TLRs), curcumin and antiapoptotic. Scientific
evidence suggests that curcumin could have a potential role to
treat COVID‐19. Thus, the use of curcumin in the clinical trial,
as a new treatment option, should be considered.
Curcumin supplementation and delayed onset muscle
soreness (DOMS): effects, mechanisms, and practical
considerations
Physical Activity and
Nutrition, September Curcumin, also called
diferuloylmethane, is a well-known spice used in curry in India
and other Asian countries. It is a natural polyphenol that has
attracted attention for its anti-inflammatory, antioxidant, and
anticancer activities. Studies have found that curcumin
significantly reduces pain from burns as well as pathological
pain caused by sciatic nerve injury, spinal cord injury,
diabetic neuropathy, and alcoholic neuropathy. Researchers in
the field of exercise physiology have investigated the effect of
curcumin on post-exercise DOMS, with a few studies reporting
that curcumin supplementation can effectively attenuate DOMS
after high-intensity eccentric exercise.
Curcumin’s
Suppressive Effects on Epithelial-Mesenchymal Transition in
Colorectal Cancer Cells Medical Science
Monitor, September 2020 Curcumin is a component of Curcuma
longa with various biological activities. The present study
aimed to investigate curcumin’s inhibitory effects on
epithelial-mesenchymal transition (EMT) in colorectal cancer
(CRC) cells and possible mechanisms of action underlying these
effects. Curcumin negatively regulated transcription factors
promoting EMT in CRC cells by decreasing cdx2 promoter DNA
methylation and consequently suppressing the
CDX2/Wnt3a/ß-catenin signaling pathway.
Potential role of Curcumin against viral infections and
pathogenesis of COVID-19
Department of
Bioanalytical Sciences, September 2020 The review intended to
provide link between natural product as treatment and COVID-19
disease. Therefore, this review summarizes the structure,
pathogenesis as well as understanding the various role of
curcumin as a treatment option for COVID-19 which includes:
targeting viral entry to host cells, targeting viral
replication, anti-viral, anti-inflammatory and anti-oxidant.
Hence, curcumin can be a potential treatment option for COVID-19
patients and this review also suggest that more clinical
research and development is needed in order to prepare a new
drug for emerging SARS-CoV-2. Curcumin as an Antiviral
Agent-Inhibition of Viral attachment/penetration. The antiviral
activities of curcumin were observed from many evidences against
vesicular stomatitis virus, parainfluenza virus type 3,
vesicular stomatitis virus, flock house virus, herpes simplex
virus, and respiratory syncytial virus. Curcumin can block the
entry and budding of the virus by altering the structure of the
surface protein in viruses. Recently, a molecular docking
analysis through in silico computational study Jena et al.
revealed that curcumin have dual binding affinity directly with
the S protein and ACE-2 receptor binding domain of the
SARS-CoV-2 virus. ACE-2 is the receptor that binds with
SARS-CoV-2 spike glycoprotein which promote the fusion
ofmembrane and viral infection occurs through endocytosis.
Therefore, spike glycoprotein is a potential candidate for drug
targeting to inhibit the entry of virus.Binding of curcumin to
receptor-binding domain (RBD) site of viral S protein and also
to the viral attachment sites of ACE-2 receptor, revealed that
curcumin can act as potential inhibitory agent for the entry of
SARS-CoV2 viral protein. This in silico docking studies
showedthat curcumin may effectively prevent the SARS-CoV2 entry
into the host cell. Many in vivo and in vitro
studies
showed that curcumin can inhibit the production and release of
pro-inflammatory response, such as IL-1, IL-6, IL-8, TNF-α.
Curcumin also decreases expression of many other inflammatory
mediators, including MCP1,MIPI1, growth regulated oncogene alpha
(GROα), GROβ, IP10, stromal cell derived factor 1 (SDF1), matrix
metalloproteinase-2 (MMP-2), IFN-γ, and MMP-9, which regulate
the activity of immune cells and inflammatory responses and
promote fibrosis in the lung after infection. Anti-inflammatory
activity of curcumin involves various signalling pathways, from
which nuclear factor kappa B (NF-kB)plays a vital role in
managing numerous inflammatory responses through multiple
mechanisms.
Does
Curcumin Have a Role in the Interaction between Gut Microbiota
and Schistosoma mansoni in Mice? Pathogens,
September 2020 Several studies have described therapeutic
effects of curcumin which may arise from its regulative effects
on intestinal microbiota. Curcumin induced high variation in the
Enterobacteriaceae family, characterized by a significant
reduction in E. coli and asignificant increase in
Pseudomonas sp. in both naïve and S. mansoni-infected mice,
compared to untreated mice, in a dose-dependent manner.
Additionally, our study showed the effects of high curcumin
doses on S. mansoni infection immunological and parasitological
parameters. These data support curcumin’s ability to promote
Pseudomonas sp. known to produce schistosomicidal toxins and
offset the sequelae of murine schistosomiasis.
Effect of concomitant treatment of curcumin and
melatonin on cisplatin-induced nephrotoxicity in rats Biomedicine & Pharmacotherapy, September 2020 Curcumin showed
a protective effect against cisplatin-induced nephrotoxicity.
Combination of curcumin and melatonin showed an additive
nephroprotective effect. Nephroprotection is attributed to
their anti-inflammatory and antioxidant actions.
Curcumin Suppresses Aldosterone-Induced CRP
Generation Evidence-Based Complementary and
Alternative Medicine, September 2020 Curcumin is the most
active ingredient of turmeric with anti-inflammation and
antioxidation effects. Here, the effect of curcumin on
aldosterone-induced C-reactive protein generation in vascular
smooth muscle and the molecular mechanisms involved were
explored. We found that curcumin inhibited aldosterone-induced
C-reactive protein generation in vascular smooth muscle cells by
interfering with the reactive oxygen species-ERK1/2 signal
pathway. The results provide new evidence for the potential
anti-inflammatory and cardiovascular protective effects of
curcumin.
Curcumin: a Wonder Drug as a Preventive Measure for COVID19
Management Indian Journal of Clinical
Biochemistry, September 2020 Curcumin is one of the natural
compounds that had been widely investigated for its antiviral
effects. Curcumin, a natural polyphenolic compound extracted
from roots of rhizome plant Curcuma longa (family
Zingiberaceae), exhibits wide range of therapeutic properties
including antioxidant, anti-microbial, anti-proliferative,
anti-inflammatory, neuroprotective and cardioprotective
properties. Curcumin, the yellow pigment of turmeric is
extensively used in our Indian traditional herbal medicines to
cure many diseases associated with infection and inflammation
for many decades. It is reported that, curcumin exerts antiviral
activities against broad spectrum of viruses including HIV,
HSV-2, HPV viruses, Influenza virus, Zikavirus, Hepatitis virus
and Adenovirus. In conclusion, we propose that curcumin could be
used as a supportive therapy in the treatment of COVID19 disease
in any clinical settings to circumvent the lethal effects of
SARS-CoV-2.
Can concomitant use of zinc and curcumin with other
immunity‐boosting nutraceuticals be the arsenal against
COVID‐19?
The Pharmacological Potential of
Plant Compounds in COVID-19, September 2020 We can expand our
discussion by taking the example of two nutritional
supplements—Curcuminoids and Zn—which have been classified under
GRAS, by FDA, as nutraceutical and nutrient. Both molecules have
a proven history of antiviral activity in both in vitro and in vivo trials, and thus could be leading in developing new
prophylactic candidates against COVID‐19. Curcumin is a natural
bioactive polyphenolic compound isolated from the dried powder
of Curcuma longa rhizomes, commonly known as turmeric (Haldi in
Hindi), and widely used worldwide for cooking. For example, it
exerts an anti‐inflammatory action in arthritis and inflammatory
bowel diseases, reduces lipid levels in cardiovascular diseases,
and addresses oxidative stress in skin disorders (Pagano,
Romano, Izzo, & Borrelli, 2018). Curcumin has an established
track record as an antiviral agent against several viruses like
Influenza Type A, Hepatitis A, Zika, HIV, etc. The mode of
action of curcumin includes—inhibition of viral entry into
cells, suppression of viral replication, stimulation of
interferons (IFNs) and other cytokines, and inhibition of viral
protein expression. In silico studies have also revealed that
curcumin binds directly with the receptor‐binding domain of the
viral spike protein (involved in host cell binding) and the
cognate host cell receptor, angiotensin‐converting enzyme‐2
(serves as a medium of viral entry), of SARS‐CoV‐2 virus (Figure
1). Moreover, curcumin has been reported to inhibit the release
and suppress numerous cytokines like IL‐1β, IL‐6, IL8, TNFα,
MCP‐1, etc. When investigated in various viral infections
set‐up, the mode of cytokine suppression by curcumin can be
correlated with clinical improvement in conditions associated
with cytokine storm (Sordillo & Helson, 2015). Following the
suggested interaction with these key components of the viral
lifecycle and immune system, it is apparent that curcumin could
prevent the COVID‐19 infection. Moreover, in recent years, blood
coagulation properties of curcumin (by inhibiting platelet
aggregation, cyclooxygenase pathway, and blocking of calcium
signaling) have been utilized in designing various materials and
devices (Keihanian, Saeidinia, Bagheri, Johnston, & Sahebkar,
2018). As the SARS‐CoV‐2 coronavirus infection can be associated
with a disseminated intravascular coagulopathy, hence curcumin
can be an effective agent against this pathological condition.
The Inhibitory Effect of Curcumin on Virus-Induced Cytokine
Storm and Its Potential Use in the Associated Severe Pneumonia
Frontiers in Cell and Developmental Biology,
September 2020 Coronavirus infection, including SARS-CoV,
MERS-CoV, and SARS-CoV2, causes daunting diseases that can be
fatal because of lung failure and systemic cytokine storm. No
drugs are available to suppress overly immune response-mediated
lung injury effectively. In light of the low toxicity and its
antioxidant, anti-inflammatory, and antiviral activity, it is
plausible to speculate that curcumin could be used as a
therapeutic drug for viral pneumonia and ALI/ARDS. Therefore, in
this review, we summarize the mounting evidence obtained from
preclinical studies using animal models of lethal pneumonia
where curcumin exerts protective effects by regulating the
expression of both pro- and anti-inflammatory factors such as
IL-6, IL-8, IL-10, and COX-2, promoting the apoptosis of PMN
cells, and scavenging the reactive oxygen species (ROS), which
exacerbates the inflammatory response. These studies provide a
rationale that curcumin can be used as a therapeutic agent
against pneumonia and ALI/ARDS in humans resulting from
coronaviral infection.
Catechin and Curcumin interact with corona (2019-nCoV/SARS-CoV2)
viral S protein and ACE2 of human cell membrane Pharmacodynamics, September 2020 The recent outbreak of
the coronavirus (2019n-CoV) is an unprecedented threat for human
health throughout the globe. Here, through computational
approaches we have reported two polyphenols, Catechin and
Curcumin which have dual binding affinity i.e both the molecule
binds to viral S-protein and as well as ACE2. Molecular
simulation study demonstrates that curcumin directly binds with
RBD site of S-protein during 40-100ns. In conclusion, this
computational study for the first time predicts the possibility
of above two polyphenols, for therapeutic/preventive
intervention.
Curcumin to inhibit binding of spike glycoprotein to ACE2
receptors: curcuminoids against novel SARS-CoV-2 Royal Society of Chemistry, August 2020 We focused on the
natural plant Curcuma longa, commonly known as turmeric, a
perennial herbaceous rhizomatous plant belonging to the ginger
family Zingiberaceae, which is widely used in India.Curcuma
longa chemical constitutes are widely used for treating various
ailments and possess a wide variety of therapeutic properties
including
antiviral,analgesic,antimicrobial,antiproliferative,and
anti-inflammatory activity. Among the various chemical
compounds, curcumin has gained importance among researchers
because its compounds have been exhibited activity against
viruses such as the human immunodeficiency virus (HIV), dengue
virus, herpes simplex virus (HSV), hepatitis virus, influenza A
virus (IAV), and Ebola virus.SARS-CoV-2 has resulted in a
devastating pandemic with global concern; however, present
therapies in virology fail to prevent its effects. Currently,
there is exigency in identifying novel leads with anti-viral
properties to impede viral pathogenesis in the host system.
Thus, two important curcuminoids of turmeric, i.e., its curcumin
keto and enol forms, were demonstrated to be complementary to
bind with the S-glycoprotein and envelope protein of SARS-CoV-2.
However, the keto form of curcumin is more favourable for both
these drug targets considering its docking score, binding energy
and molecular dynamics simulation. Thus, this study indicates
that surface proteins are key drug target proteins of
SARS-CoV-2, and probably curcumin blocks essential biologically
active drug target residues, thereby attenuating the viral
infection. Hence, this computational biology approach identifies
curcumin as a drug candidate for further investigation in
treating SARS-CoV-2.
Antiviral and virucidal effects of curcumin
Journal of General Virology, August 2020 Emerging
coronaviruses represent serious threats to human and animal
health worldwide, and no approved therapeutics are currently
available. Here, we used Transmissible gastroenteritis virus
(TGEV) as the alpha-coronavirus model, and investigated the
antiviral properties of curcumin against TGEV. Our results
demonstrated that curcumin strongly inhibited TGEV proliferation
and viral protein expression in a dose-dependent manner. We also
observed that curcumin exhibited direct virucidal abilities in a
dose-, temperature- and time-dependent manner. Furthermore,
time-of-addition assays showed that curcumin mainly acted in the
early phase of TGEV replication. Notably, in an adsorption
assay, curcumin at 40 µM resulted in a reduction in viral titres
of 3.55 log TCID50 ml–1, indicating that curcumin possesses
excellent inhibitory effects on the adsorption of TGEV.
Collectively, we demonstrate for the first time that curcumin
has virucidal activity and virtual inhibition against TGEV,
suggesting that curcumin might be a candidate drug for effective
control of TGEV infection.
Turmeric could have antiviral properties Microbiology Society, August 2020 Curcumin, a natural
compound found in the spice turmeric, could help eliminate
certain viruses, research has found. A study published in the
Journal of General Virology showed that curcumin can prevent
Transmissible gastroenteritis virus (TGEV) – an alpha-group
coronavirus that infects pigs – from infecting cells. At higher
doses, the compound was also found to kill virus particles. The
research suggests that curcumin affects TGEV in a number of
ways: by directly killing the virus before it is able to infect
the cell, by integrating with the viral envelope to ‘inactivate’
the virus, and by altering the metabolism of cells to prevent
viral entry. “Curcumin has a significant inhibitory effect on
TGEV adsorption step and a certain direct inactivation effect,
suggesting that curcumin has great potential in the prevention
of TGEV infection,” said Dr Lilan Xie, lead author of the study
and researcher at the Wuhan Institute of Bioengineering.
Curcumin has been shown to inhibit the replication of some types
of virus, including dengue virus, hepatitis B and Zika virus.
The compound has also been found to have a number of significant
biological effects, including antitumor, anti-inflammatory and
antibacterial activities. Curcumin was chosen for this research
due to having low side effects according to Dr Xie.
Turmeric may have antiviral properties labonline, August 2020 To determine the potential antiviral
properties of curcumin, scientists from the Wuhan Institute of
Bioengineering treated experimental cells with various
concentrations of the compound, before attempting to infect them
with TGEV. They found that higher concentrations of curcumin
reduced the number of virus particles in the cell culture.
Curcumin enhances anti‑cancer efficacy on pancreatic
cancer cells Oncology Reports, August 2020 Curcumin is a natural compound extracted from turmeric (Curcuma
longa), which has been reported to be a promising anti‑cancer
drug in various human cancers. Curcumin exhibited marked
suppressive ability on metastasis of PC cells by wound healing
and matrigel‑transwell assay. Mechanistically, upregulation of
TIMP1/TIMP2 with concomitant downregulation of
MMP2/MMP9/N‑cadherin proteins may be involved in this process.
In conclusion, curcumin showed synergistic anti‑cancer effects
with either gemcitabine or docetaxel on PC cells.
Accelerated Muscle Recovery After In Vivo Curcumin
Supplementation Graduate Institute of
Metabolism and Obesity Sciences, August 2020 For the
contusion-induced muscle injury, curcumin could affect the
specific proteins of inflammation, neutrophils, and
differentiation of satellite cells, including Ikk-α/ß, MPO, and
myogenin. In conclusion, curcumin potentially accelerates muscle
recovery; therefore, it may be a potential candidate for further
research as an effective treatment to enhance muscle repair.
Curcumin Protects Against Radiotherapy-Induced
Oxidative Injury to the Skin Drug Design,
Development and Therapy, August 2020 The administration of
curcumin before and after irradiation prevented
radiotherapy-induced oxidative damage by significantly elevating
the activities of antioxidant enzymes. From the findings of the
present study, curcumin showed potential for protection against
radiotherapy induced oxidative injury to the skin. However,
future studies are required to evaluate its clinical efficacy.
The Spice That Protects Your Brain TheEpochTimes, August 2020 Previous research on curcumin
indicates that it is capable of acting as an antioxidant in
three distinct ways by protecting against 1) singlet oxygen, 2)
hydroxyl radicals, and 3) superoxide radical damage. Also,
curcumin appears to raise endogenous glutathione production in
the brain, a major antioxidant defense system. Supplementation
with curcumin significantly reduced the toxic effect of fluoride
to near normal level by augmenting the antioxidant defense
through its scavenging property and provides evidence of having
a therapeutic role against oxidative stress mediated
neurodegeneration.” This is far from the first study to
demonstrate curcumin’s remarkable brain-saving properties. From
the perspective of the primary research alone, there are more
than 200 peer-reviewed published studies indicating that
curcumin is a neuroprotective agent. On GreenMedInfo’s turmeric
database there are 115 articles proving turmeric protects the
brain. There are also two featured studies on turmeric’s ability
to protect and restore the brain: How Turmeric Can Save the
Aging Brain From Dementia and Premature Death, and Turmeric
Produces ‘Remarkable’ Recovery in Alzheimer’s Patients.
Considering the many chemical insults we face on a daily basis
in the post-industrial world, turmeric may very well be the
world’s most important herb, with more than 800 evidence-based
health applications.
Effects of curcumin, D-pinitol alone or in
combination in cytotoxicity induced by arsenic Food and Chemical Toxicology, August 2020 Curcumin
decreases cell viability of PC12 cells unlike D-pinitol. Arsenic
induced cell death via both mitochondria-mediated intrinsic
apoptosis and autophagy. Curcumin and D-pinitol alone or in
combination efficiently protects PC12 cells from arsenic-induced
cytotoxicity. The combined cytoprotection of curcumin and
D-pinitol against arsenic-toxicity was higher than their
individual protection.
Magical benefits of herbs Northampton Chronicle, August 2020 Curcumin is undergoing
many studies to investigate its anti-inflammatory properties.
Already shown to be able to slow down inflammation, there are
clinical trials being performed comparing this compound with
anti-inflammatory drugs, like Ibuprofen. Curcumin has also been
linked to helping pre-menstrual tension, acne, arthritis,
depression. Clinical studies are also under way to investigate
its function with Alzheimer’s Disease and some cancers.
Potential Effects of Curcumin in the Treatment of COVID-19
Infection Phytotherapy Research, July 2020 Coronavirus disease (COVID-19) outbreak is an ongoing pandemic
caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) with considerable mortality worldwide. The main
clinical manifestation of COVID-19 is the presence of
respiratory symptoms, but some patients develop severe
cardiovascular and renal complications. There is an urgency to
understand the mechanism by which this virus causes
complications so as to develop treatment options. Curcumin, a
natural polyphenolic compound, could be a potential treatment
option for patients with coronavirus disease. In this study, we
review some of the potential effects of curcumin such as
inhibiting the entry of virus to the cell, inhibiting
encapsulation of the virus and viral protease, as well as
modulating various cellular signaling pathways. This review
provides a basis for further research and development of
clinical applications of curcumin for the treatment of newly
emerged SARS-CoV-2.
Antiviral benefits of curcumin
nutritionaloutlook, July 2020
A
new review explores the potential effects of curcumin on
COVID-19 infection. Based on existing data from in silico and
animal studies on curcumin and viral infection, the review
serves as a groundwork for future study of curcumin as a
possible treatment. The review cites studies that point to
curcumin’s ability to potentially inhibit the entry of virus to
the cell, inhibit encapsulation of the virus and viral protease,
as well as modulate various cellular signaling pathways. The
review also cites studies in which curcumin was effective in
pulmonary inflammation, fibrosis, and edema, as well as the
recuperative actions of curcumin on cardiac and kidney damage
caused by viral infections.
Curcumin - Properties, Applications and Modification of
Structure eurekaselect, July 2020
In
recent years, the interest in biologically active compounds of
natural origin has increased significantly. Researchers'
research focuses on increasing the activity of curcumin by
forming complexes with metals such as vanadium, iron, copper or
gallium. Introduction of metal compounds to curcumin increases
the scope of application in pharmacology. The main direction of
research development is the treatment of tumors, among others
stomach cancer or leukemia. Curcuminoids are the main components
of turmeric (Curcuma longa L.), a plant from India and
South-East Asia. Due to its intense yellow-orange color and
pleasant aroma, the powdered rootstalk is widely used in the
food industry, as natural dye and spice. The chemical compound
responsible for the characteristic color of rhizomes of curcuma
is 1,6-heptadien-3,5-dione-1,7-bis(4-hydroxy-3-methoxyphenyl) -
(1E, 6E) called curcumin. This work aims to characterize
curcumin in terms of its structure, therapeutic properties and
also as a substrate for the synthesis of valuable derivatives
like tetrahydrocurcumin. Knowledge about this relationship based
on literature analysis will enable a better understanding of the
factors responsible for its biological activity.
Turmeric: The Spice for Life ttownmedia,
July 2020 For centuries it has been known that turmeric
exhibits anti-inflammatory activity, but extensive research
performed within the past two decades has shown that this
activity of turmeric is due to curcumin. The process of
inflammation has been shown to play a role in most chronic
illnesses, including neurodegenerative, cardiovascular and
autoimmune. In this study published in the Jan. 2009 issue of
the " International Journal of Biochemistry & Cell Biology"
researchers provided evidence for the potential role of curcumin
in the prevention and treatment of various proinflammatory
chronic diseases. Because curcumin can help keep blood sugar
levels steady, it could be effective as a way of preventing or
treating type 2 diabetes. One study, as reported in an article
on turmeric in WEB MD, followed 240 adults with prediabetes and
found that taking a curcumin supplement over 9 months lowered
their odds of developing diabetes. Additionally, curcumin has
shown promise for its ability to ease joint pain, stiffness,
abdominal pain, headaches and migraines. There is evidence to
suggest the curcumin may help in weight loss. Studies find that
curcumin may regulate lipid metabolism, which plays a central
role in the development of obesity and its complications. `
Research published in the journal "Pharmaceutical Research" Jan
2017 discusses the evidence of curcumin's effectiveness on
pulmonary diseases such as asthma, COPD, pulmonary fibrosis and
lung cancer. According to Dr. Goel, Ph.D., director of Cancer
Prevention at Baylor University Medical Center and curcumin
researcher: "Curcumin demonstrates superior antioxidant and
anti-inflammatory effects and provides liver- and
heart-protective benefits as well. It is a potent antibacterial,
antifungal, antiviral, anti-allergenic and has antitumor and
anti-cancer properties." A Randomized Controlled Trial reported
in the Aug. 2009 issue of "The Journal of Alternative and
Complementary Medicine" conclude that curcumin was as safe and
effective for treating knee osteoarthritis as ibuprofen. A 2016
Meta-Analysis of over 28 studies concluded that scientific
evidence supported the efficacy of turmeric extract (about 1000
mg/day of curcumin) in the treatment of arthritis.
Curcumin-enhanced antitumor effects
Food &
Function, July 2020 Curcumin, the main active ingredient of
turmeric, is widely used as a kind of food additive and also
displays a range of pharmacological activities, such as
anti-inflammation, anti-tumor, liver and kidney protection, and
so forth. It was found that curcumin protected against
liver cancer progression through reducing the level of alpha
fetoprotein in liver tissues, increasing the number of immune
cells, like NK cells, inhibiting EMT via the regulation of
IL-6/JAK/STAT3 and IL-1β/NF-κB pathways, suppressing anaerobic
glycolysis through the inhibition of LDH and HIF-1α, and
decreasing the lipid synthesis via the downregulation of FASN,
and upregulated the serum HDL-C and mRNA levels of apoA1 in the
sorafenib-treated mice. Furthermore, curcumin regulation of the
disorder of glycolipid metabolism and EMT was also based on the
PI3K/AKT pathway. A docking study was performed and proved the
strong affinity between curcumin and the proteins of STAT3,
FASN, and AKT. All in all, this experiment provided evidence for
the addition of curcumin in the diet to enhance the antitumor
efficacy of sorafenib through activating immune function,
downregulating EMT, and reversing disorders of the metabolism.
Support Your Immune System
marieclaire,
July 2020 Turmeric rates as a high immunity-boosting food due
to the levels of curcumin that are found in it. Curcumin can
enhance the antibody response by activating the T cells, B
cells, neutrophils (white blood cells that heal damaged tissues
and resolve infections) and Natural Killer cells, all of which
help your body to fight off infection. Curcumin is also a
fantastic anti-inflammatory, which helps your immune system by
reducing the amount of inflammation within your body. The more
inflammation you have, the less able your body is able to fight
off any potential microbes.
Curcumin
exerts protective effect on PC12 cells europeanreview, July 2020 Our study indicates that curcumin
exerts protective effect against lidocaine-induced cytotoxicity
on PC12 cells by suppressing the activity of NLRP3 inflammasome,
which provides new ideas on screening natural product for
neurological damage therapy.
Curcumin protects BV2 Molecular Biology
Reports, July 2020 Curcumin was demonstrated to be an active
ingredient with anti-inflammatory effects. This research was to
investigate the effects of curcumin. We found that curcumin
promoted cell viability and suppressed cell apoptosis.
Meanwhile, curcumin decreased the level of cleaved caspase-3 and
the release of TNF-α, IL-1β, IL-6, but increased IL-10 release
in LPS-treated BV2 cells. Furthermore, curcumin suppressed p-p65
expression via regulating miR-362-3p/TLR4 axis. We discovered
that curcumin exhibited protective effects against LPS-triggered
cell injury via modulating miR-362-3p/TLR4 axis through NF-κB
pathway.
Improving Lung Function
ndtv, July 2020 Curcumin in turmeric has antioxidant and anti-inflammatory
effects which can be beneficial for supporting lung function.
Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Oxidative Medicine and Cellular Longevity, July 2020 Curcumin, a natural polyphenol antioxidant extracted from the
root of turmeric (Curcuma longa), can induce apoptosis and DNA
demethylation in several types of cancer cells. We observed that
curcumin inhibited the proliferation, colony formation, and
migration of hGCCs in a dose- and time-dependent fashion. A high
concentration of curcumin elevated ROS levels and triggered
mitochondrial damage, DNA damage, and apoptosis of hGCCs.
Further, curcumin-induced DNA demethylation of hGCCs was
mediated by the damaged DNA
repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis. We propose
that the anticancer effect of curcumin could largely be
attributed to its prooxidative effect at high concentrations and
ROS elevation in cancer cells. Moreover, we present a novel
mechanism by which curcumin induces DNA demethylation of hGCCs,
suggesting the need to further investigate the demethylation
mechanisms of other DNA hypomethylating drugs.
Type 2 diabetes: A spice
proven to help lower blood sugar and help with treatment express.co.uk In a study with the US National Library of
Medicine National Institutes of Health, curcumin and how it
affects diabetes was investigated. The study noted: “The active
component of turmeric, curcumin, has caught attention as a
potential treatment for diabetes and its complications primarily
because it is a relatively safe and inexpensive drug that
reduces glycemia and hyperlipidaemia in rodent models of
diabetes. “The spice turmeric, which is derived from the root of
the plant Curcuma longa, has been described as a treatment for
diabetes in Ayurvedic and traditional Chinese medicine for
thousands of years. “Recent research has provided the scientific
basis for “traditional” curcumin and confirmed the important
role of curcumin in the prevention and treatment of diabetes and
its associated disorders. Curcumin could favourably affect most
of the leading aspects of diabetes, including insulin
resistance, hyperglycaemia, hyperlipidaemia, and islet apoptosis
and necrosis.”
Curcumin Potentiates Laryngeal Squamous Carcinoma Cancer
Journal of Receptors and Signal Transduction, July
2020 Curcumin has shown efficacy in promoting
radiosensitivity combined with radiotherapy. Curcumin
significantly enhanced irradiation-induced DNA damage and
apoptosis, while weakening clone-forming abilities of LSCC cell
line Hep2 and Hep2-max. Compared to Hep2 cells, Hep2-max cells
are more sensitive to curcumin post-irradiation. Curcumin
enhances LSCC radiosensitivity via NF-ΚB inhibition by
suppressing IKKγ expression.
Curcumin For Better Memory?
drweil.com July
2020 Curcumin is a compound found in the spice turmeric. Both
give the yellow color to curry powder and American mustard. The
possibility that curcumin could prevent – or treat – memory
problems, including Alzheimer’s disease, is suggested in part by
population studies showing that elderly villagers in India have
the world’s lowest rate of Alzheimer’s, perhaps because their
traditional diet provides turmeric with almost every meal.
Curcumin is a powerful antioxidant and also has
anti-inflammatory properties that might protect against
Alzheimer’s, which begins as an inflammatory process in the
brain. The latest findings on curcumin’s effects come from a
small, double-blind, placebo-controlled UCLA study showing that
curcumin supplements improved memory and mood in 40 people
between the ages of 51 and 84 with mild, age-related memory
loss. The participants were randomly assigned to receive either
90 milligrams of an easily absorbed form of curcumin twice daily
for 18 months or a placebo. The form of curcumin used in this
study is key; many forms are not well absorbed from the GI
tract, so that little gets into the bloodstream and even less
gets past the blood-brain barrier. All the UCLA study
participants received standardized cognitive assessments when
the study began and every six months afterwards. In addition, 30
of them had PET scans at the investigation’s beginning and end
to determine their levels of amyloid-beta and tau, the abnormal
proteins that make up the plaques and tangles that progressively
obstruct cerebral function in Alzheimer’s disease. At the end of
the study, the team found that memory improved by 28 percent in
the participants who took curcumin. No such changes occurred in
those who received the placebo. Those who took curcumin also
showed mild improvements in mood, and their PET scans revealed
significantly less amyloid and tau proteins in brain regions
that control memory and emotional functions. In news reports,
the study’s first author, Gary Small, M.D., director of
geriatric psychiatry at UCLA’s Longevity Center, said it isn’t
known exactly how curcumin exerts theSE effects, but they may be
due to its ability to reduce brain inflammation, A factor in
both Alzheimer’s disease and major depression.
Managing autoimmune disorders
Times Of
India, July 2020 Curcumin is the main active ingredient in
turmeric. It has powerful anti-inflammatory effects and is a
very strong antioxidant. It helps the body fight foreign
invaders and also has a role in repairing damage. Circumin helps
fight many autoimmune diseases. It not just neutralizes free
radicals on its own but also stimulates the body's own
antioxidant enzymes. Curcumin leads to various changes at the
molecular level that may help prevent and even heal a cancer.
Struggle with Schizophrenia? Curcumin May Make the Difference
Natural Path Newsletter, July 2020 To see if
curcumin could widen the treatment to include the negative
symptoms of schizophrenia, researchers added either a placebo or
3g of curcumin a day to the antipsychotic drugs of 38 people
with chronic schizophrenia in a double-blind study. At the end
of the six month study, there was a significantly better
response in the curcumin group on the Positive and Negative
Symptoms Scale (PANSS) and on the negative symptoms subscale.
The researchers call these results “promising” because they
suggest a safe, effective, natural way of addressing the
previously resistant negative symptoms of schizophrenia.
Antibacterial Mechanism of Curcumin: A Review
Chemistry & Biodiversity, July 2020 Curcumin is a
plant‐derived polyphenolic active substance with broad‐spectrum
antibacterial properties. Curcumin blocks bacterial growth owing
to its structural characteristics and the generation of
anti‐oxidation products. Curcumin can inhibit bacterial
virulence factors, inhibit bacterial biofilm formation and
prevent bacterial adhesion to host receptors through the
bacterial quorum sensing regulation system. Moreover, it can
exert a synergistic antibacterial effect with other
antibacterial substances. In this review, we summarize the
research progress on the antibacterial mechanism of curcumin
based on five targeting structures and two modes of action. Our
discussion provides a theoretical basis and technical foundation
for the development and application of natural antibacterial
agents.
Benefits of using Turmeric
bolnews, July
2020 Turmeric dramatically increases the antioxidant capacity
of the body. The main reason antioxidants are so beneficial is
that they protect your body from free radicals. Curcumin is a
potent antioxidant that can neutralize free radicals due to its
chemical structure. Turmeric boosts levels of the brain hormone
BDNF, which increases the growth of new neurons and fights
various degenerative processes in your brain. Turmeric leads to
several changes on the molecular level that may help prevent and
perhaps even treat cancer.
Curcumin ameliorates CKD-induced mitochondrial dysfunction and
oxidative stress The Journal of Nutritional
Biochemistry, July 2020 Curcumin could exert beneficial
effects, including weight maintenance and improved muscle
function, increased mitochondrial biogenesis, alleviated
mitochondrial dysfunction by increasing adenosine triphosphate
levels, activities of mitochondrial electron transport chain
complexes and basal mitochondrial respiration and suppressing
mitochondrial membrane potential. In addition, curcumin
modulated redox homeostasis by increasing antioxidant activity
and suppressed mitochondrial oxidative stress. Moreover, the
protective effects of curcumin had been found to be mediated via
inhibiting GSK-3β activity in vitro and in
vivo. Importantly,
GSK-3β KO contributed to improved mitochondrial function,
attenuated mitochondrial oxidative damage and augmented
mitochondrial biogenesis in muscle of CKD. Overall, this study
suggested that curcumin alleviated CKD-induced mitochondrial
oxidative damage and mitochondrial dysfunction via inhibiting
GSK-3β activity in skeletal muscle.
How to live longer
express.co.uk, July 2020 In a study with the US National Library of Medicine National
Institutes of Health, turmeric extract and its active compound,
curcumin and how it can help with liver damage was investigated.
The study noted: “Curcumin, a major active component of
turmeric, has previously been reported to alleviate liver
damage. “We hypothesized that turmeric extract and curcumin
protect the liver by reducing oxidative stress, inhibiting lipid
peroxidation.” The study found that curcumin can protect against
liver damage and that potential liver and gallbladder benefits
of curcumin include increasing production of the digestive fluid
bile while also protecting liver cells from damage from
bile-associated chemicals.
Studies on Curcumin with COVID-19 Proteins
Biochemistry, June 2020 Curcumin, a natural bioactive
molecule has been shown to have a therapeutic potential for
various diseases, but no role of it in COVID-19 has been
explored. In this work, we show the binding potential of
curcumin targeted to a host of SARS-CoV-2 proteins. Our results
indicate that curcumin has potential antiviral protein binding
affinity towards SARS-CoV-2 proteins which is comparable with
other repurposed drugs that are considered for clinical trials.
Effects of curcumin on neurological diseases
Pharmacological Reports, June 2020 Curcumin, the major
active component of turmeric, belongs to the curcuminoid family
that was originally isolated from the plant Curcuma longa.
Several studies suggest that curcumin may have a beneficial
impact on the brain pathology and aging. These effects are due
to curcumin’s antioxidant, free-radical scavenging, and
anti-inflammatory activity. In light of this, our current review
aims to discuss the role of astrocytes as essential players in
neurodegenerative diseases and suggest that curcumin is capable
of direct inhibition of astrocyte activity with a particular
focus on its effects in Alexander disease, Alzheimer's disease,
ischemia stroke, spinal cord injury, Multiple sclerosis, and
Parkinson’s disease.
Effects of curcumin on breast cancer cell proliferation
International Journal of Oncology, June 2020 Only curcumin and B(Cur)2 inhibited cell migration. Furthermore,
cell exposure to curcumin resulted in an increase in the
relative expression of the two key proapoptotic proteins,
cytochrome c and cleaved caspase‑3, as well as the antiapoptotic
protein haem oxygenase‑1. In addition, curcumin increased the
expression levels of the voltage‑gated potassium channels Kv2.1
and Kv3.2. Similarly, the expression levels of the chloride
channel bestrophin‑1 and the calcium channel coding gene calcium
voltage‑gated channel auxiliary subunit γ4 were increased
following exposure to curcumin. Fe(Cur)3 and B(Cur)2 may
display similar anticancer properties as curcumin.
Curcumin's potential to fight COVID-19 Manorama Online, June 2020 Curcumin is an integral part of
two among the three research projects undertaken by MG varsity
VC and his team of scientists
Consequences of long-term low-dose curcumin exposure in lung
cancer cells Molecules, June 2020 Curcumin has been investigated extensively for cancer
prevention, but it has been proposed that long-term treatments
may promote clonal evolution and gain of cellular resistance,
potentially rendering cancer cells less sensitive to future
therapeutic interventions. Curcumin (0.25–0.5 µM) was able to
inhibit the invasion of both native and chemo-resistant NSCLC
cells in the organotypic co-culture model.
Local doctor says food, spices in your home could
boost your immunity Boston 25 News, June
2020 A recent New York Times article said that most
Americans don’t have the diet or overall health to fight
COVID-19. A Weymouth doctor said a strong immune system is
needed to fight the virus. Dr. Pat Hopkins, a rheumatologist and
director of the Boston Functional Medicine Group, looks at the
root cause of diseases. “I always like to say the best offense
is a good defense so you’re building up your immune system,”
Hopkins said. “If you get the virus your immune system should
roll over and say no problem.” Hopkins said the best way to
flatten the curve and protect yourself from coronavirus.
Here’s a list of Hopkins’ top supplements to help boost your
immunity: Curcumin, 500 to 1000 MG twice a day.
Bioactive immunity booster PinkVilla.com
June 2020 The key substance which makes turmeric so useful
and powerful is Curcumin. Due to its antioxidant,
anti-inflammatory, and antimicrobial properties, it aids to
combat inflammation, which is the origin of many chronic
diseases in the body and also lessens immunity. It has also
proven to be a super ingredient to strengthen joints, have a
stronger heart, sharper brain, and a healthy liver. Curcumin is
also effective for healthy and glowing skin and its consumption
keeps viruses and infections at bay.
Curcumin ameliorates CKD-induced mitochondrial dysfunction and
oxidative stress through inhibiting GSK-3β activity The Journal of Nutritional Biochemistry, June 2020 Curcumin
has been reported to attenuate muscle atrophy. Moreover,
the protective effects of curcumin had been found to be mediated
via inhibiting GSK-3β activity in vitro and in
vivo.
Importantly, GSK-3β KO contributed to improved mitochondrial
function, attenuated mitochondrial oxidative damage, and
augmented mitochondrial biogenesis in muscle of CKD. Overall,
this study suggested that curcumin alleviated CKD - induced
mitochondrial oxidative damage and mitochondrial dysfunction via
inhibiting GSK-3β activity in skeletal muscle.
Antiviral Foods To Boost Your Immune System Refinery29.com June 2020 Curcumin, a compound found in
turmeric, has powerful anti-inflammatory properties. Davis says
that even low doses of it enhances antibody responses, an
indicator that your body is fighting off illnesses. You can cook
with turmeric, a spice, but you can find curcumin supplements at
any health food store too.
Lower concentrations of curcumin inhibit Her2-Akt pathway
components in human breast cancer cells Nutrition Research, June 2020 Curcumin has emerged as a
potential co-treatment for this and other cancers, but prior
studies have focused on non-attainable concentrations. These
studies demonstrate that a physiological attainable level of
curcumin (1.5 μM) can reduce some components of the critical
Her2-Akt pathway; that even more complete inhibition can be
achieved by combination with other dietary botanicals; and that
curcumin and other botanicals can potentiate the action of the
human epidermal growth factor receptor 2 cancer metastatic drug
lapatinib, in turn suggesting the potential anti-cancer clinical
use of these botanicals.
Curcumin for the Management of Periodontal Diseases: A Review Current Pharmaceutical Design, June 2020 Periodontal disease
is one of the most common causes of tooth loss among adults.
Research shows that inflammation is one of the crucial
components in the initiation and progression of periodontitis.
Various herbal medicines have recently been receiving attention
for the management of periodontitis owing to their general
safety and efficacy. Curcumin, a bioactive polyphenol extracted
from Curcuma longa, has been shown to possess antioxidant,
antimicrobial, anti-inflammatory and analgesic properties.
Several studies have assessed the efficacy of curcumin against
periodontal diseases. These studies have shown equivalent or
even higher efficacy of curcumin compared to the commonly used
medications for the management of periodontitis such as
chlorhexidine. Herein, we review the experimental and clinical
findings on the anti-periodontitis effects of curcumin and the
pharmacological mechanisms underlying these effects.
The Best Anti-Aging Supplements For Longevity Longevity Live, June 2020 Curcumin is responsible for the
vibrant yellow color of turmeric. With its anti-inflammatory
effects, curcumin could be exactly what your aged skin needs. In
fact, one study associated turmeric intake with a reduced risk
of age-related mental decline in humans. A separate study
published in the Phytotherapy Research journal found that the
topical application and oral ingestion of curcumin supplements
helped to alleviate the appearance of not only aging, but that
of skin damage caused by UV rays.
Curcumin alleviates OGD/R‐induced PC12 cell damage via
repressing CCL3 to suppress inflammation and apoptosis Journal of Pharmacy and Pharmacology, June 2020 Curcumin
presents some therapeutic effects including anti‐cancer and
anti‐inflammation. Herein, we centered on the functional role of
curcumin in cerebral ischaemia injury and its potential
molecular mechanisms. Our study manifested that curcumin might
be a meritorious drug for the treatment of cerebral ischaemia by
acting on CCL3.
Best supplements for diabetes - the 'amazing' capsules to
protect against high blood sugar Express,
June 2020 Curcumin improves insulin
resistance in some diabetes patients, according to nutritionist
Dr Sarah Brewer. The spice could also protect against some of
the severe complications of high blood sugar. Its
anti-inflammatory properties mean that patients aren't as likely
to develop neuropathy, or damage to their blood vessels. People
with prediabetes could also benefit from taking turmeric
supplements, added the nutritionist. "Curcumin supplements have
also been shown to improve insulin resistance by activating
insulin receptors. "In people with poor glucose tolerance
[prediabetes], turmeric can delay the onset of type 2 diabetes.
"These are amazing results and it’s no wonder that turmeric is
an increasingly popular natural treatment for type 2 diabetes."
Curcumin inhibited mitochondrial apoptosis induced by PCV2 virus
Research Square, June 2020 Curcumin has
significant antiviral effect. And the PCV2-induced Mitochondrial
apoptosis was mainly remitted by Curcumin.
Putting health first
Daily Pioneer, June
2020 Known for its anti-oxidant and anti-inflammatory
properties, Curcumin, the compound present in turmeric is a very
potent agent and aids in healing of wounds and infections. This
bright yellow, bitter spice has also been used for years as an
anti-inflammatory in treating both osteoarthritis and rheumatoid
arthritis. Research shows that high concentrations of curcumin,
which gives turmeric its distinctive color, can help decrease
exercise-induced muscle damage. Curcumin has promise as an
immune booster (based on findings from animal studies) and an
antiviral.
Curcumin
(Diferuloylmethane) Induces Apoptosis in Mantle Cell Lymphoma Biochemical Pharmacology, June 2020 We used curcumin, a
pharmacologically safe agent, to target NF-kappaB in a variety
of MCL cell lines. On treatment of cells with curcumin, however,
downregulated constitutive active NF-kappaB and inhibited the
consitutively active IkappaBalpha kinase (IKK), and
phosphorylation of IkappaBalpha and p65. Curcumin also inhibited
constitutive activation of Akt, needed for IKK activation.
Consequently, the expression of all NF-kappaB-regulated gene
products, were downregulated by the polyphenol leading to the
suppression of proliferation. Overall, our results indicate that
curcumin inhibits the constitutive NF-kappaB and IKK leading to
suppression of expression of NF-kappaB-regulated gene products
that results in the suppression of proliferation, cell cycle
arrest, and induction of apoptosis in MCL.
Exercise and Curcumin in Combination Improves
Cognitive Function and Attenuates ER Stress in Diabetic Rats Nutrients, June 2020 Curcumin is a natural compound with
known antioxidant and anti-inflammatory properties. Exercise plus
curcumin improved escape latency and memory retention compared
to OLETF controls. Furthermore, OLETF rats exercised and fed
curcumin had lower IL6, TNFα, and IL10 levels (indicators of
inflammatory response) and lower levels of ER stress markers
(BiP and CHOP) in the intestine than OLETF controls. These
observations suggest exercise plus curcumin may offer a means of
treating diabetes-related cognitive dysfunction.
Curcumin Administration Mitigates Oxidative Damage
and Restores Alteration of Enzymes Associated with Cognitive
Function in Rats’ Brain Neurotoxicity
Research, June 2020 Curcumin also improved redox balance and
showed protection against cyclophosphamide-induced oxidative
damage to rats’ brain via an increase in protein and non-protein
thiols and nitric oxide levels as well as a significant
reduction in malondialdehyde levels. Curcumin also prevented
neuronal degeneration in different brain regions and reduced
caspase-3 expression. Hence this study suggests that pre and
post-treatment with curcumin improved neurobehavior, modulates
some biomarkers associated with cognitive function and exhibit
neuroprotection against cyclophosphamide-induced neurotoxicity
in rats.
Curcumin Confer Radiosensitizing Effect in Breast
Cancer American Journal of Biochemistry and
Molecular Biology, May 2020 Curcumin reduced the
proliferation rate of cells. Correspondingly, wound healing
assay resulted in control of the cell-cell interaction and cell
migration at two different time points. Conclusion: In
conclusion, curcumin along with a lower dose (8 Gy) of radiation
acted as the best combinatorial drug treatment for breast cancer
cell lines. Our findings put up a rationale for further
clinical/preclinical analysis of combination treatments with a
lower dose and fewer side effects in breast cancer.
COVID-19: Herbs That Strengthen Your Immune System outlookindia, May 2020 Turmeric contains a bioactive compound
known as curcumin, which acts as an anti-inflammatory agent.
Curcumin effect on cancer cells Phytotherapy Research, May 2020 Curcumin is a natural
phenolic compound which shows potent anticancer activities in
different tumors, alone or as an adjuvant with other antitumor
drugs to prevent or inhibit the survival and cancer progression
by various mechanisms. The role of curcumin in overcoming drug
resistance was followed by reviewing different applications of
curcumin in cancer therapy. Afterward, the clinical impacts of
curcumin, role of curcumin in decreasing drug resistance in
different cancer cells and its mechanisms were discussed. It has
been demonstrated that curcumin regulates signaling pathways in
cancer cells, reduces the expression of proteins related to drug
resistance, and increases the performance of antitumor drugs at
various levels. Curcumin reverses multidrug resistance
mechanisms and increases sensitivity of resistance cells to
chemotherapy. This review mainly focuses on different mechanisms
of drug resistance and curcumin as a nontoxic natural substance
to eliminate the effects of drug resistance through modulation
and controlling cell resistance pathways and eventually suggests
curcumin as a potent chemosensitizer in cancers.
Benefits Of Turmeric You Might Not Have Known republicworld, May 2020 Turmeric is rich in curcumin; it can
reduce inflammation by blocking enzymes that cause tissue
inflammation. Curcumin has powerful antioxidant effects. It
helps to reduce or even prevent some of the potential damage
that free radicals can cause. According to recent research by
Healthline, turmeric's antioxidant and anti-inflammatory
capacity mostly related to its compound curcumin may play a role
in weight loss.
Chemopreventive effect of green tea and curcumin in
induced oral squamous cell carcinoma Alexandria Dental Journal, May 2020 Curcumin, a natural
polyphenol, is one of the most investigated biomolecules from
Mother Nature. Curcumin has been shown to exert significant
growth inhibitory effect on oral precancerous and carcinoma cell
lines, and the effect is synergistic with epigallocatechin
gallate, the most abundant polyphenol in tea. Conclusions: Green
tea and curcumin have a significant chemopreventive effect
against oral cancer.
Investigation of phytochemical screening and
antimicrobial activity of Curcuma longa International Journal of Advanced Research in Biological
Sciences, May 2020 Many plants have been screened for
antimicrobial activity and drug properties. The aim of the
present study encourages the use of spices as alternative or
supplementary medicine to reduce the burden of high cost, side
effects and progressively increasing drug resistance of
pathogens. In present study methanol and chloroform extracts of
Curcuma longa (fresh and dry) were prepared from the rhizome.
The antimicrobial properties of both of the extract were studied
by testing the antibacterial as well as antifungal activity. The
antibacterial test was done by agar well diffusion method
against bacterial species such as Escherichia coli,
Staphylococcus aureus, Klebsiella pneumoniae, Protease vulgaris,
Pseudomonas aeruginosa, Bacillus cereus, Bacillus megatarium,
Bacillus subtilis and fungal species such as Aspergillus niger.
The zone of inhibition of the extract were determined and
compared with the standard drug streptomycin to know the
efficiency. The methanol extract of rhizome was found to be more
effective when compared with other solvent like chloroform. The
phytochemical analysis of both of the extract revealed the
presence of alkaloids, flavonoids, terpenoids, tannins, saponin
and steroids.
Protective effects of curcumin on bleomycin-induced
changes in lung glycoproteins Molecular and
Cellular Biochemistry, May 2020 Curcumin inhibited the
increases in complex carbohydrates and glycosidases in the
fibrotic lungs. These findings suggest that BLM-induced lung
fibrosis is associated with accumulation of glycoproteins, and
curcumin has the ability to suppress the enhanced deposition of
glycoproteins in the fibrotic lung.
Nutrition: Is turmeric good for you?
newtimes, May 2020 They say turmeric and its most
active compound known as curcumin has many scientifically-proven
health benefits, such as the potential to prevent heart disease,
Alzheimer’s and cancer, as well as a potent anti-inflammatory
and antioxidant. Nutritionists say the primary active component
of turmeric and the one that gives the spice its characteristic
yellow colour is curcumin. In fact, they say that one can credit
curcumin as the compound responsible for most of turmeric’s
potential health benefits. Studies have shown that curcumin
found in turmeric is an effective anti-carcinogen, a substance
that helps prevent cancer. Besides, Uwiragiye notes that the
medicinal property in turmeric is able to boost the immune
system, even in people with immune disorders. During this time
when we are faced with the novel coronavirus, it’s essential for
people to consume foods that help in boosting their immunity,
and turmeric should be one of them. This is because it has been
proven that the virus affects people with the low immune system
more. Research shows that the curcumin found in turmeric may
help prevent Alzheimer’s, and, turmeric’s antioxidants prevent
damage that can lead to Alzheimer’s. Meanwhile, studies have
proven that curcumin in turmeric may help treat and prevent
diabetes as well as associated disorders like diabetic
nephropathy (also called diabetic kidney disease), which affects
people with type 1 and 2 diabetes.
Effects of Curcumin on the Renal Toxicity
Antioxidants, May 2020 Curcumin (CURC), due to its
therapeutic effects, has been chosen for our study to reduce the
toxic renal effects induced by OTA. This study shows that
curcumin can mitigate OTA-induced oxidative damage in the
kidneys of rats.
COVID-19: Scientific Review with Natural & Holistic Methods for
Immune Boosting ModernHana, April 2020 CURCUMIN This chemical from the Indian spice, Tumeric, does many
good things for the body. Kang et al 2019 study titled Curcumin
inhibits Th1 cytokine profile in CD4+ T cells by suppressing
interleukin-12 production in macrophages” published in the
British Journal of Pharmacology suggest that Curcumin can likely
help reduce excess inflammation (cytokine storm) in the lungs.
Jagetia GC and Aggarwal BB , 2007 study titled “ "Spicing up" of
the immune system by curcumin” published in the Journal Clinical
Immunology also suggests that Curcumin has potent immune
benefits that can help fight infections.
A
cost-effective preventative approach to potentially save lives
in the coronavirus pandemic, jointly using Vitamin D, Curcumin,
and Vitamin C NutriXiv, April 2020 In
the current absence of specific pharmaceutical agents, we
propose assessing the extended tools that we already possess in
our biological armoury to combat, prevent and control the spread
of this virus. Using a set of precise criteria to locate such
possible contenders, we conducted literature searches to find
compounds that met these criteria. We have now reduced this to a
shortlist of three agents that may be the best candidates. We
propose vitamin C, vitamin D and Curcumin fit our criteria well.
These compounds are widely available to the general public. They
are available online and over-the-counter as supplements.
Otherwise healthy individuals are safely able to self-administer
these agents as a prophylactic to protect themselves and to
enhance their immune response. This would be especially
desirable for the elderly and at risk groups. These agents can
also be used as adjunct therapy, particularly for those who may
have early symptoms. This preventative therapy could be
implemented whilst awaiting specific pharmaceutical drugs to
emerge as a treatment for COVID-19. Our suggested compounds are
a highly cost-effective way to potentially reduce the mortality
that is regretfully mounting as a result of COVID-19 infection.
Enhance Your Immunity Amid Coronavirus Crisis Medical Daily, April 20 "Turmeric has antiseptic, analgesic
and immune boosting properties (that serve) as a line of defense
against colds, flu and inflammation due to the active polyphenol
called curcumin," Amanda Griggs, nutritionist at the
Khera-Griggs Cleanse Clinic at the Urban Retreat in London,
explained.
Application
of curcumin and its derivatives in tumor multidrug resistance Phytotherapy Research, April 2020 Curcumin (CUR) has not only
antitumor activity but also reversing tumor MDR effect. CUR
reverses tumor MDR via regulating related signal pathways or
corresponding expressed proteins or gene. When combined with
chemotherapeutic agents, CUR can be a chemotherapeutic sensitive
agent to enhance chemotherapy efficacy and weaken tumor MDR.
Dietary Supplementation with Curcumin Reduce Circulating Levels
of Glycogen Nutrients, April 2020 Dietary supplementation with curcumin has been previously
reported to have beneficial effects in people with insulin
resistance, type 2 diabetes (T2D) and Alzheimer’s disease (AD).
Dietary supplementation with curcumin reduced circulating levels
of IAPP and GSK-3β, thus suggesting a novel mechanism through
which curcumin could potentially be used for alleviating insulin
resistance related markers for reducing the risk of T2D and AD.
Curcumin Reverses the Scopolomine-induced Cognitive Impairment
International Journal of Pharmaceutical Sciences
and Drug Research, April 2020 Curcumin is a polyphenolic
compound, known for its antioxidant, anti-inflammatory,
neuroprotective, and precognitive properties. Present study
reported that curcumin showed anti-amnesic effect in animal
models of cognitive impairment of schizophrenia. Curcumin
reduced the TL compared to toxic control group (scopolamine per
se) (P <0.001) in elevated plus maze. In spontaneous alteration
behaviour test, curcumin significantly increased percentage
alteration and possible alteration as compared to toxic control
group (P <0.001). The present study put forward the claim of
curcumin as a new and safer therapeutic option for the treatment
of cognitive impairment in Schizophrenia. The underlying
mechanism of this potential effect may be related to
anticholinesterase and nitric oxide synthase inhibition activity
of curcumin.
Curcumin and Endometriosis International
Journal of Molecular Sciences, April 2020 Curcumin is a major
anti-inflammatory agent. Several findings have highlighted the
anti-oxidant, anti-inflammatory and anti-angiogenic properties
of curcumin. The purpose of this review is to summarize the
potential action of curcumin in endometriosis by acting on
inflammation, oxidative stress, invasion and adhesion, apoptosis
and angiogenesis.
Type 2 diabetes: Curry spice to add to foods to lower blood
sugar Express, April 2020 A scientific
paper from the Beijing University of Chinese Medicine and McGill
University reviewed studies of how curcumin from the around the
world could help with better type 2 diabetes management. In many
of the studies it was found that curcumin reduced blood sugar
and cholesterol levels for those with diabetes. Curcumin was
found to improve insulin function which reduces insulin
resistance by helping them enter the cells needed to repair and
do its function. On top of helping lower blood sugar levels and
improve insulin functions, curcumin was also found to be an
excellent weight loss booster. Health experts found that
curcumin prevented liver fat accumulation in studies on rats. It
found that rats who consumed curcumin had reduced liver fat on a
high-fat diet compared to rats not consuming curcumin and aided
in weight loss. One of the best type 2 diabetes management one
could do is lose weight if overweight and curcumin could help
with this. The studies also found that curcumin helped to fight
off cancers and even helped those suffering with erectile
dysfunction.
Ward off your cancer risk with spices
The
Health Site, April 2020 Good old turmeric is your has been
your kitchen companion forever. Almost all your dishes have
turmeric in them. The good news is, curcumin, a component of
turmeric can reduce your cancer risk, finds a spate of studies.
A study published in the journal Gastroenterology found that
this compound prevented the growth of colon cancer tumours.
Curcumin is also known to protect you from other Alzheimer’s,
diabetes, arthritis pain, etc.
Coronavirus Pandemic: Here’s How to Boost Your Immunity at Home News18, March 2020 Turmeric: A common spice in India and
Asia. Turmeric contains curcumin which is known to enhance
immune function. Adding turmeric to your food will help you
boost your immunity.
Tips on Staying Safe During the COVID-19 Outbreak by a Doctor
The Quint, March 2020 The active ingredient
curcumin has been shown in several studies to stop the ‘cytokine
storm’ of pro-inflammatory chemicals in the body, in the earlier
epidemics of SARS and Ebola viruses.
What can I do to boost my immunity? Is there any medication able
to treat coronavirus? COVID-19 questions answered by Cleveland
Clinic doctor WKYC, March 2020 Dr.
Roizen: There are a lot of things that boost immunity. Vitamin D
is one of those reported to boost immunity. Curcumin is reported
to boost it.
A recent study by Indonesia's Airlangga University suggested
curcumin — a component of turmeric — could reduce inflammation
in the lungs and help boost immunity against the virus.
ABC, March 2020
Protect your body against coronavirus
InfoSurhoy, March 2020 Consuming anti-inflammatory rich foods
is essential when it comes to the immune system.. The compound
in turmeric known as curcumin holds a plethora of benefits.
Precaution and prevention best medicines to avoid Covid-19 Times of India, March 2020 Dr
Varinder and Dr Naveen Airi specified that there there is no
treatment for Coronavirus. The only way to prevent is to boost
immunity via homeopath medicines like Ginseng, Curcumin
Turmeric, or curcumin, known for reducing inflammation in the
body, can help fight off coronavirus, according to some medical
experts IndiaWest, March 2020 NEW DELHI –
Turmeric, or curcumin, is being advocated by some medical
experts for reducing lung inflammation amid the rising COVID-19
cases in India. The virus is especially known to attack the
respiratory system. Turmeric is being touted as the only way to
keep inflammation in your body low so that you have a better
chance of fighting the coronavirus infection.
"Curcumin
(a diferuloylmethane) was found to be the most widely studied compound as
evinced by more than 9000 citations in the literature, with antioxidant,
anti-inflammatory, anticancer, antiviral, antibacterial, antidiabetic,
antiarthritic, antiatherosclerotic, antidepressant, antiaging, antimicrobial,
wound healing and memory-enhancing activities. Moreover, it exerts
chemopreventive, chemosensitization and radiosensitization effects as well. In
traditional Indian medicine, this spice has been also used to treat different
ailments such as gynecological problems, gastric problems, hepatic disorders,
infectious diseases, blood disorders, acne, psoriasis, dermatitis, rash and
other chronic ailments. Diverse in vivo studies have also indicated its
potential against pro-inflammatory diseases, cancers, neurodegenerative
diseases, depression, diabetes, obesity and atherosclerosis. Besides its safety and
tolerability, cost-effectiveness is an added advantage of this compound. To date, over
100 different clinical trials have been completed with curcumin, which clearly
show its safety, tolerability and its effectiveness against various chronic
diseases in humans." -
British Journal of
Pharmacology
"7,000 published articles have shed light on
the various aspects of curcumin including its antioxidant, hypoglycemic,
anti-inflammatory and anti-cancer activities. Oxidative stress and inflammation
play a pivotal role in various diseases like diabetes, cancer, arthritis,
Alzheimer's disease and cardiovascular diseases."
-
Food and Chemical Toxicology Journal
"6.000 articles published within the past two decades
have discussed the molecular basis for the antioxidant, anti-inflammatory,
antibacterial, antiviral, antifungal, and anticancer activities assigned to this
nutraceutical. Over sixty five clinical trials conducted on this molecules, have
shed light on the role of curcumin in various chronic conditions, including
autoimmune, cardiovascular, neurological, and psychological diseases, as well as
diabetes and cancer." -
Biotechnology Advances Journal
"Curcumin has been used as pharmacological traditional medicinal
agent in Ayurvedic medicine for 6000 years. The current review
article presents effective role of curcumin against cancer, diabetes,
oxidative stress, cardiovascular, obesity, and aging. Curcumin is a
promising and significant natural bioactive compound which has been
shown to possess numerous pharmacological activities including
anticancer, antidiabetic, cardiovascular protective, antiobesity,
antimicrobial, wound healing, and nephroprotective activities. The
molecule has also potential to protect from reproductive and
respiratory disorders in association with its strong antioxidant
potential. In near future, curcumin is expected to be proven as a
novel drug to treat and cure several human disorders such as c arcinogenesis,
inflammatory disorders, and oxidative stress-induced pathogenesis." -
Trends in Food Science & Technology
Turmeric to resist COVID-19 Saxon, March 2020 Turmeric. Its main component curcumin is
considered a powerful immune booster, acts as an
anti-inflammatory.
Curcumin Inhibits the Tumorigenesis of Breast Cancer Cancer Management and Research, March 2020 Curcumin is an
active phenolic pigment that is isolated from turmeric (Curcuma
longa). Curcumin has diverse properties on tumor cells,
including anti-proliferation, anti-inflammatory, and
anti-oxidant. Previous studies have shown that curcumin
can effectively suppress the invasion and proliferation of human
cancers, such as wilms’ tumor (WT) esophageal cancers, and
pancreatic cancer. Jia et al have found that the proliferation,
invasion and migration of WT cells are restrained by the
treatment of curcumin. Dharmalingam et al have shown that
curcumin treatment inhibits the proliferation and colony
formation of esophageal cancer cells in a dose and
time-dependent manner. Choudhuri et al have proved that curcumin
induces the apoptosis of BC cells. In addition, Bang and Kim
have confirmed that curcumin significantly inhibits the motility
and invasion of BC cells. The anti-tumor role of curcumin has
been identified by a large number of researches. Curcumin
(20 and 30 μM) inhibited the proliferation, migration and
invasion, and promoted the apoptosis of MCF-7 and MDA-MB-231
cells. Curcumin decreased the protein expression of TAZ and YAP
in MCF-7 and MDA-MB-231 cells. Overexpression of YAP reversed
the anti-tumor effect of curcumin on MDA-MB-231 cells. In
addition, curcumin (100, 200 and 300 mg/kg/d) inhibited the
growth of tumor xenografts in mice, and down-regulated the
protein expression of TAZ and YAP in tumor xenografts. Curcumin
at a concentration of 300 mg/kg/d slowed the increasing of body
weight in mice. Conclusion: Curcumin inhibited the tumorigenesis
of BC by blocking TAZ/YAP axis
Curcumin and Colorectal Cancer: An Update and Current
Perspective On This Natural Medicine
Seminars in Cancer Biology, March 2020 Curcumin, derived from
the plant Curcuma longa, represents one such option that has a
long history of its use for a variety of chronic disease
including cancer, in Indian ayurvedic and traditional Chinese
medicine. Scientific evidence over the past few decades have
overwhelmingly shown that curcumin exhibits a multitude of
anti-cancer activities orchestrated through key signaling
pathways associated with cancer. In this article, we will
present a current update and perspective on this natural
medicine - incorporating the basic cellular mechanisms it
effects and the current state of clinical evidence, challenges
and promise for its use as a cancer preventative and potential
adjunct together with modern therapies for CRC patients.
Therapeutic Effects of Curcumin against Bladder Cancer
Anti-Cancer Agents in Medicinal Chemistry, March 2020 Curcumin is a well-known plant-derived polyphenol found in
turmeric. This compound has numerous pharmacological effects
such as antioxidant, anti-inflammatory, anti-diabetic and
anti-tumor properties. Curcumin is capable of suppressing the
growth of a variety of cancer cells including those of bladder
cancer. Given the involvement of various signaling pathways such
as PI3K, Akt, mTOR and VEGF in the progression and malignancy of
bladder cancer, and considering the potential of curcumin in
targeting signaling pathways, it seems that curcumin can be
considered as a promising candidate in bladder cancer therapy.
In the present review, we describe the molecular signaling
pathways through which curcumin inhibits invasion and metastasis
of bladder cancer cells.
Coronavirus: Antiviral Cationic Carbon Dots Based on
Curcumin ACS Publications, March 2020 Here, we report a one-step method to apply curcumin in order to
prepare of uniform and stable cationic carbon dots (CCM-CDs)
with antiviral properties. These results offer theoretical
support for the development of CCM-CDs as a hopeful antiviral
drug for the treatment of coronavirus infections, including
PEDV.
In the fight against cancer: Scientists say compound
curcumin found in the popular spice has tumour-killing potential
DailyMail, March 2020 Scientists analyzed
almost 5,000 studies and found curcumin blocked the growth of
eight types of cancers, under laboratory settings. Results
showed it was effective at treating breast, lung, blood,
stomach, pancreatic, bowel, bone marrow and prostate cancer. The
academics from Temple University in Philadelphia say curcumin
stops nutrients from being transported to tumours.It also
prevents the death of healthy cells by blocking cancer cells
from releasing harmful proteins. The academics concluded
curcumin - the pigment in turmeric that gives it its colour -
could 'represent an effective drug for cancer treatment.
Curcumin Attenuates Colistin-Induced Peripheral
Neurotoxicity ACS Infectious Diseases,
March 2020 Orally applied curcumin was detected in the brain,
cerebellum, and sciatic nerve. Co-administration of oral
curcumin markedly improved colistin-induced impaired sensory and
motor dysfunctions in a dose-dependent manner. Curcumin
supplementation at 100 and 200 mg/kg significantly decreased
lipid peroxidation and upregulated catalase (CAT) and superoxide
dismutase (SOD) activities, ATP levels, and Na+/K+-ATPase
activity in sciatic nerve tissue, compared to the colistin alone
group. Curcumin supplementation at 200 mg/kg upregulated the
levels of AKT, NGF, mTOR, Nrf2, and HO-1 mRNA and concomitantly
downregulated Bax, caspases-3, and -9 mRNA; it also decreased
caspase-3 and caspase-9 activity. In summary, for the first
time, our study reveals that the protective effect of oral
curcumin on colistin induced peripheral neurotoxicity is
associated with the activation of NGF/Akt and Nrf2/HO-1 pathways
and inhibition of oxidative stress. This study highlights the
potential clinical application of curcumin as an oral
neuroprotective agent coadministered during colistin therapy.
Curcumin attenuates copper-induced oxidative stress and
neurotoxicity Toxicology Reports, March
2020 Curcumin is a hydrophobic polyphenol derived from the
rhizome of the Herb Curcuma longa belonging to the family
Zingiberaceae. Curcumin possesses antioxidative,
anti-inflammatory and anti-depressant-like properties. Our
findings suggest that Curcumin ameliorated Cu2+-induced
neurotoxicity in D. melanogaster and as such could be considered
an effective therapeutic agent in the prevention and treatment
of disorders, where oxidative stress is implicated.
Antioxidant, Anti-Inflammatory, and Antiapoptotic
Potential of Curcumin in Benzo(a)pyrene (BaP)-Induced Lung
Injury Journal of Thoracic Oncology, March
2020 Curcumin (Cur) has potent anti-inflammatory, antioxidant
activity that defences cells from oxidative stress and cell
death. Thus, curcumin may be an alternative therapy for
improving the outcomes of Benzo(a)pyrene -induced lung injury.
Curcumin, an Active Constituent of Turmeric Spice:
Implication in the Prevention of Lung Injury Molecules, March 2020 Curcumin is an active ingredient of
Curcuma longa, and it has potent anti-inflammatory, antioxidant
activity that defends cells from oxidative stress and cell
death. Overall, our findings suggest that curcumin attenuates
BaP -induced lung injury, probably through inhibiting
inflammation, oxidative stress and apoptosis in lung epithelial
cells, and improving cell proliferation and antioxidants level.
Ease Joint Pains Caused By Arthritis By Using This
Spice Extract IB Times, March 2020 Long
praised for its anti-inflammatory properties, turmeric is
becoming the focus of various studies on pain alleviation. The
key ingredient of this popular Asian spice is curcumin, an
active compound found in this flowering plant. A review summary
of various controlled tests found that a thousand milligrams per
day of curcumin can reduce osteoarthritic inflammation and pain.
Its efficacy is comparable to that of non-steroidal
anti-inflammatory drugs or NSAIDs like ibuprofen and diclofenac.
In another study conducted in 2016, results show that curcumin
may help prevent the breakdown of bones in people with
rheumatoid arthritis. You must choose curcumin extract over the
whole turmeric, according to the Arthritis Foundation.
Curcumin on Improving Cognitive Function in an
Alzheimer’s Disease Neurochemical Research,
March 2020 Berberine and curcumin are extracts from
traditional Chinese herbs that have a long history of clinical
benefits for Alzheimer’s disease. Here, using a transgenic
Alzheimer’s disease mouse model, we found that the combined
berberine and curcumin treatment had a much better effect on
improving the cognitive function of mice than the single-drug
treatment, suggesting synergic effects of the combined berberine
and curcumin treatment. In addition, we found that the combined
berberine and curcumin treatment had significant synergic
effects on reducing soluble amyloid-β-peptide(1–42) production.
Furthermore, the combination treatment also had remarkable
synergic effects on decreasing inflammatory responses and
oxidative stress in both the cortex and hippocampus of
Alzheimer’s disease mice. We also found that the combination
treatment performed much better than the single drugs in
reducing the APP and BACE1 levels and increasing AMPKα
phosphorylation and cell autophagy, which might be the
underlying mechanism of the synergic effects. Taken together,
the result of this study reveal the synergic effects and
potential underlying mechanisms of the combined berberine and
curcumin treatment in improving the symptoms of Alzheimer’s
disease.
Bidirectional interactions between curcumin and gut
microbiota in transgenic mice with Alzheimer’s disease Applied Microbiology and Biotechnology, March 2020 Curcumin
administration tended to improve the spatial learning and memory
abilities and reduce the amyloid plaque burden in the
hippocampus of APP/PS1 mice. On the one hand, curcumin
administration altered significantly the relative abundances of
bacterial taxa such as Bacteroidaceae, Prevotellaceae,
Lactobacillaceae, and Rikenellaceae at family level, and
Prevotella, Bacteroides,a nd Parabacteroides at genus level,
several of which have been reported to be key bacterial species
associated with Alzheimer’s disease development. On the other
hand, a total of 8 metabolites of curcumin biotransformed by gut
microbiota of Alzheimer’s disease mice through reduction,
demethoxylation, demethylation and hydroxylation were identified
by HPLC-Q-TOF/MS, and many of these metabolites have been
reported to exhibit neuroprotective ability. The findings
provided useful clues to understand the pharmacology of curcumin
and microbiome-targeting therapies for Alzheimer’s disease.
Best Supplements To Take For Better Brain Health
Medical Daily, March 2020 Turmeric is
potent anti-inflammatory, as such it has already shown potential
in animal studies to reduce or help prevent brain cell damage.
Taking tumeric helps supplement DHA (docosahexaenoic acid)
deficiency, which can make people more prone to cognitive
disorders. Curcumin, the compound present in turmeric, helps in
the synthesis of DHA, therefore providing neuroprotection.
Inhibitory Effect of Curcumin on Artery Restenosis Drug Design, Development and Therapy, March 2020 Curcumin is
a natural phenolic substance extracted from the rhizome of the
plant Curcuma longa. Turmeric is commonly present in ordinary
diets and its traditional use for the treatment of various
diseases in China originates from several eons ago. Extensive
investigations indicate that Cur has diverse pharmacological
effects, such as antiinflammatory, antioxidant,
antiproliferative and anticarcinogenic, whereas it also protects
against the development of cerebrovascular diseases. Curcumin
provides these beneficial effects due to its ability to regulate
certain molecular targets, including adhesion molecules, growth
factors, transcription factors, and factors involved in
proliferation and apoptosis that are associated with several
different cell types. Certain studies have shown that Curcumin
can inhibit the proliferation of VSMCs and prevent stent
restenosis following angioplasty. Curcumin inhibited the
proliferation of smooth muscle cells and neointimal formation
and reduced the inflammation and oxidative stress indices.
Concomitantly, Curcumin reduced the phosphorylation of the
Raf/MEK/ERK pathway proteins. Conclusion: Curcumin could inhibit
carotid restenosis following CEA by inhibiting the activation of
the Raf/MEK/ERK pathway.
Boost Your Immunity Today
Online, March 2020 The healing benefits of turmeric have been
widely documented. Used in India for centuries as a spice and
medicinal herb, turmeric contains curcumin, a potent antioxidant
that can help neutralise free radicals, and also natural
anti-inflammatory compounds, which help your body fight
pathogens and repair damage.
Healthy Foods for Your Liver Livestrong,
March 2020 Turmeric is having its day in the sun thanks to it
being a potent source of curcumin, a powerful antioxidant.
Curcumin helps to reduce oxidative stress by neutralizing the
harmful components of oxidative stress, according to July 2018
research published in Nutrients. Why's this important? Our daily
routines can really wreak havoc on the liver: Alcohol and
medications — even over-the-counter meds — can cause stress on
the liver. And it's not just any run of the mill stress; it's
oxidative stress. Chronic oxidative stress could mean liver
damage if it's not addressed. Curcumin also has a
hepatoprotective effect on the liver, which means it can prevent
liver damage thanks to its anti-inflammatory properties.
Mutual
Two-Way Interactions of Curcumin and Gut Microbiota The International Journal of Molecular Sciences, February 2020 Curcumin is a natural phenolic component derived from the
Curcuma longa plant and has been used in India to treat
inflammation. Due to its chemical structure, this molecule can
be used in several different areas, such as food, textiles and
the pharmaceutical industry. Curcumin is widely used as a spice
and dye in food products with a characteristic yellow color;
therefore, it is consumed daily. Curcumin is a spice that has
recently gained great interest and is widely used in Ayurvedic
medicine. Curcumin is a promising compound that is easily
available and easy to use in the diet, and it is also safe and
affordable. Currently available data provide evidence that
curcumin has antitumor activity, induces neuroprotection and
neurogenesis, and can be a new therapeutic agent in both
regenerative medicine and neurodegenerative diseases, such as
post-ischemic neurodegeneration and Alzheimer’s disease.
Protective Effects of Curcumin Against Nephrotoxic
Agents Cardiovascular & Hematological
Disorders-Drug Targets, February 2020 Curcumin is the one of
the main phenolic ingredients in curcuma species rhizome.
Curcuma species have traditionally been used for the treatment
of diabetes, cardiovascular, and renal diseases. Studies have
shown the protective effects of curcumin against nephrotoxic
agents such as gallic acid, glucose, tartrazine, streptozotocin,
lead, cadmium, fluoride, maleate, malathion, nicotine,
cisplatin, gentamicin, and methotrexate. The current review
indicated that curcumin may be effective against nephrotoxicity
by modulating oxidative stress and inflammatory responses.
Benefits of Turmeric University of Utah,
February 2020 Researchers have found that phytochemicals from
natural foods, such as the curcumin found in turmeric, may be a
safe and effective way to help reduce inflammation and prevent
and treat disease. While acute inflammatory responses are
beneficial for the body in that they help heal injury,
irritation, or infection, we know that chronic inflammation can
contribute to disease onset. There is promising research to
support curcumin’s use for the anti-inflammatory and antioxidant
effects on obesity, to reduce arthritis pain and swelling, and
to aid in complications such as diabetic retinopathy,
nephropathy, and cardiomyopathy.
Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on
Tongue Cancer Drug Design, Development and
Therapy, February 2020 Curcumin has potential therapeutic
effect on treating tongue cancer by suppressing cell
proliferation and migration, as well as promoting apoptosis
through modulating oxygen-related signaling pathways.
Add This Spice To Your Diet To Improve Your Chances In Fighting
Cancer IB Times, February 2020 Today,
scientists reveal that this unassuming plant contains curcumin,
a compound that can kill a tumor and stop the proliferation of
cancer cells. Researchers conclude turmeric may soon become an
effective anti-cancer drug due to the antioxidant and
anti-inflammatory powers of curcumin. They reveal that curcumin
has shown great potential in killing cancer cells in particular
types of cancer. Scientists, however, stopped short in saying
they already found the cure for cancer. They admitted more
research is needed to establish the cancer-stopping potential of
the turmeric compound firmly. For now, it appears that curcumin
has achieved considerable success in killing cancer cells and
stop the unabated growth of rogue cells. It also has shown
greater efficacy in dealing with stomach cancer, breast cancer,
skin cancer, and bowel cancer cells.
Effect of curcumin supplementation on disease
severity in patients with liver cirrhosis Phytotherapy Research, February 2020 Recent reports indicated
that curcumin had beneficial effects in animal models of liver
injury and cirrhosis. Current study aimed to investigate the
effects of curcumin supplementation in patients with liver
cirrhosis. In this pilot study, beneficial effects of curcumin
supplementation were observed in decreasing disease activity
scores and severity of cirrhosis in patients with cirrhosis.
One Spice Can Help You Lose The Nasty Visceral Fat IB Times, February 2020 According to an Express report, the
fat-burning benefits of turmeric stems from curcumin. This is
the chemical that is found in turmeric and has been linked to
weight loss. In a study that involved 44 overweight people, the
researchers found that when they take curcumin even just twice
in a month, they noticed how effective it was in aiding the
process of weight loss. It was attributed to a decrease in belly
fat. It also helped reduce weight. Aside from the study
involving the 44 individuals, a separate study on mice showed
that mice that were given curcumin for 12 weeks showed a
reduction in body weight. They found out that it blocked the
synthesis of fat. Combining the results of both studies, it
would show how effective curcumin is in weight loss.
Superfoods & cancer risks Deccan Herald, February 2020 Curcumin is an antioxidant found
in turmeric. It helps the body to fight against HPV and protect
against cervical cancer by slowing down or limiting the activity
of the virus.
The In-Vitro Effect of Curcumin and Arsenic Trioxide
on The Level Of NF-kB and Induction of Apoptosis in B16 Cell
Lines Karbala Journal of Medicine,
February 2020 Curcumin is a natural product that had been
utilized for a variety of maladies like rheumatic, cardiac,
neurological and numerous other disorders. Curcumin had very
potent concentration dependent anti-cancer effects against B16
MM cell line.
CBD and Turmeric – Why This Is A Great Combination prospercbdnews.com, February 2020 Turmeric, the spice also
known as Indian saffron, comes from the Ginger family. It has
several properties that overlap those of cannabidiol which is
what makes it a wonderful addition to CBD products. Turmeric has
been used in Ayurvedic practices for centuries. It has a
therapeutic nature and several medicinal applications. Being a
strong anti-inflammatory agent, turmeric improves brain, heart,
and joint health. The curcumin in turmeric is where its strength
lies.
Curcumin Attenuates Oxaliplatin-Induced Liver Injury
and Oxidative Stress by Activating the Nrf2 Pathway
Drug Design, Development and Therapy, February 2020 Curcumin
attenuates oxaliplatin-induced liver injury and oxidative stress
by activating the Nrf2 pathway, which suggests that CUR may be
potentially used in the prevention and treatment of OXA-induced
liver injury.
Adding Curcumin to Mesalamine May Benefit Patients
With Ulcerative Colitis
empr.com, February
2020 Adjunctive therapy with curcumin was found to provide a
greater clinical benefit than placebo in patients with
ulcerative colitis (UC) being treated with mesalamine, according
to the findings of a recently published systematic review and
meta-analysis. The study authors reported that the odds of
clinical response were approximately threefold better for
patients who received the combination of mesalamine plus
curcumin vs placebo.“This response was statistically
significant, albeit with heterogeneity, probably due to the
different severity scoring indices, curcumin dosages and routes
of drug delivery used,” the authors stated. They added, “Given
the minimal adverse events, we recommend that curcumin be
considered as an adjunct to mesalamine in the treatment of UC."
Effect of curcumin on expression of μ opioid
receptors Civilica.com, February 2020 Recent studies have shown that curcumin, the active ingredient
of turmeric, reduces the symptoms of withdrawal syndrome in
morphinedependent mice. Treatment with curcumin resulted in a
significant and dose-dependent attenuation of withdrawal
syndrome along with a decrease in the expression of spinal μ
opioid receptors in morphine-dependent rats. The maximum effect
was obtained from curcumin at the dosage of 10 mg/kg. The
results of this study indicate that curcumin is capable of
attenuating morphine dependence in rats through decreasing the
expression of spinal opioid μ receptors.
Curcumin supplementation improves
heat-stress-induced cardiac injury The
Journal of Nutritional Biochemistry, February 2020 Curcumin
may increase animal survival and lifespan under heat stress.
Our results indicated that curcumin supplementation could
alleviate HS-induced physiological disorders and the increasing
of cTn-I and Ang II. The expression of AT1 gene in HT group was
significantly higher than that of curcumin groups, indicating
the cardioprotective effects of curcumin. Moreover, the levels
of GRP78 and CHOP proteins in the HT group were significantly
higher than those of curcumin groups, indicating that curcumin
supplementation reversed the endoplasmic reticulum HS-mediated
apoptosis. In summary, curcumin supplementation alleviates
physiological stress and cardiac damage caused by HS.
Modulation
of Exercise-Induced Muscle Damage, Inflammation, and Oxidative
Markers by Curcumin Supplementation in a Physically Active
Population Nutrients, February 2020 Curcumin, a natural polyphenol extracted from turmeric, has been
shown to have mainly antioxidant and also anti-inflammatory
properties. This effect of curcumin could improve
Exercise-Induced Muscle Damage and exercise performance. The use
of curcumin reduces the subjective perception of the intensity
of muscle pain; reduces muscle damage through the decrease of
creatine kinase (CK); increases muscle performance; has an
anti-inflammatory effect by modulating the pro-inflammatory
cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight
antioxidant effect. In summary, the administration of curcumin
at a dose between 150–1500 mg/day before and during exercise,
and up until 72 hours post-exercise, improved performance by
reducing EIMD and modulating the inflammation caused by physical
activity. In addition, humans appear to be able to tolerate high
doses of curcumin without significant side-effects.
Curcumin
and Cancer Nutrients, January 2020 Curcumin, a polyphenol extracted from Curcuma longa in 1815, has
gained attention from scientists worldwide for its biological
activities (e.g., antioxidant, anti-inflammatory, antimicrobial,
antiviral), among which its anticancer potential has been the
most described and still remains under investigation. The
present review focuses on the cell signaling pathways involved
in cancer development and proliferation, and which are targeted
by curcumin. Curcumin has been reported to modulate growth
factors, enzymes, transcription factors, kinase, inflammatory
cytokines, and proapoptotic (by upregulation) and antiapoptotic
(by downregulation) proteins. This polyphenol compound, alone or
combined with other agents, could represent an effective drug
for cancer therapy.
How turmeric could offer hope in the fight against CANCER:
Scientists say compound curcumin found in the popular spice has
tumour-killing potential DailyMail, January
2020 A compound found in turmeric could unlock new treatments
in the battle against cancer, a scientific review has suggested.
Researchers say the anti-inflammatory and antioxidant powers of
curcumin mean it could halt the development of tumours. They
analysed almost 5,000 studies and found it blocked the growth of
eight types of cancers, under laboratory settings. Results
showed it was effective at treating breast, lung, blood,
stomach, pancreatic, bowel, bone marrow and prostate cancer.
Curcumin, a compound found in turmeric, could ‘halt tumour
development’, major study says College Of
Medicine, January 2020 New scientific research has found that
a common compound found in the spice turmeric could stop
cancerous tumours from growing further. A study, carried out by
academics at Temple University in Philadelphia, and published in
the Nutrients journal, found the antioxidant and
anti-inflammatory properties of curcumin halted the development
of eight different types of cancer. Analysing nearly 5,000
studies, researchers said the compound – which gives turmeric
its bright orange colour – was effective at treating pancreatic,
bowel, bone marrow, prostate, breast, lung, blood and stomach
cancer. Results showed nutrients that the tumours needed to
thrive were halted by curcumin, which also blocked harmful
proteins produced by cancer cells. The study’s lead scientists
concluded that the compound could ‘represent an effective drug
for cancer treatment, alone or combined with other agents’. Dr
Antonio Giordano, a pathologist at Temple University, lead a
team who looked at almost 13,000 studies carried out on curcumin
since 1924, focusing specifically on 4,738 studies that looked
at how the compound affected cancer. The study’s authors said:
“The search for new effective drugs able to combat cancer
diseases still represents a challenge for many scientists.
“Natural organisms (e.g., plants, bacteria, fungi) provide many
active molecules with a potential application in medicine for
the management of many diseases. “As reported in the present
review, curcumin exhibits anticancer ability by targeting
different cell signaling pathways including growth factors, [the
transport of nutrients and killing healthy cells].”
Curcumin, as a potent anticancer agent for the treatment of
breast cancer First International
Conference on Management of Agricultural Sciences, January 2020 Curcumin, an orange-yellow component of turmeric or curry
powder, is a highly pleiotropic molecule which shows promising
effects on various pro-inflammatory diseases, inflammatory
conditions, hepatic conditions, metabolic syndromes,
degenerative eye conditions, etc. Over the past decades,
numerous studies have demonstrated that curcumin has several
anticancer effects in various types of cancers, including breast
cancer.Materials and Methods: In the present review, we aimed to
investigate the role of curcumin on the treatment of breast
cancer. For this purpose, we searched scientific databases
including Scopus, Pubmed, Clinical key, etc.Results: The growth
inhibitory effect of curcumin has been studied on different
models of breast cancer. Our findings showed that curcumin
inhibits the growth of breast cancer cells by suppressing cell
proliferation and metastasis and inducing cell death without no
toxicity to normal cells. Importantly, curcumin treatment
increases the effectiveness of chemotherapy and decreases the
number of cancer stem cells. There are studies showing that the
ability of curcumin to reduce chemoresistance tumor cells, to
inhibit the reattachment of BCSCs, and to prevent the migratory
ability of Breast cancer stem cells.Conclusion: Based on our
findings, it is recommended that the use of curcumin can have
beneficial effects on the survival rates of patients with breast
cancer.
Curcumin compound in turmeric could help beat
cancer
The Saxon,
January 2020 Academics from Temple University in Philadelphia
say curcumin stops nutrients from being transported to tumours.
It also prevents the death of healthy cells by blocking cancer
cells from releasing harmful proteins. The academics concluded
curcumin – the pigment in turmeric that gives it its colour –
could ‘represent an effective drug for cancer treatment, alone
or combined with other agents’.
7 Fitness-Supporting Supplements That Get The RDN
Stamp Of Approval
MindBodyGreen, January
2020 As the active ingredient in turmeric root, curcumin is a
powerful antioxidant and anti-inflammatory that has been shown
to help reduce stress from physical activity. Think of this
potent yellow spice as an herbal aid in recovery: "Studies show
curcumin may relieve joint discomfort associated with exercise
or overuse," says Blakely, "which can help you get back in the
gym for your next workout faster."
Curcumin, as a pleiotropic agent, improves
doxorubicin-induced nephrotic syndrome in rats.
Journal of Ethnopharmacology, January 2020 Curcumin, a
phenolic compound extracted from the rhizome of turmeric
(Curcuma longa L.), has been reported to have broad biological
functions including potent antioxidant and renoprotective
effects. It has been reported that Curcumin has a certain
protective effect on the kidney. The consequences of this study
revealed that curcumin activated Nrf2, inhibited NF-κB pathway
and up-regulated podocin in DOX-induced podocyte. Further
research results showed that curcumin can considerably alleviate
proteinuria and improve hypoalbuminemia in NS rats, and lower
blood lipid levels to alleviate hyperlipidemia in NS rats,
indicating that curcumin has significant therapeutic effects on
rat NS. Further observation by electron microscopy and detection
showed that curcumin can improve renal function and podocyte
injury, which may be related to the repairment of mRNA
expression and podocin protein. Interestingly, the results of
the blood rheology test showed that curcumin can effectively
reduce whole blood viscosity (WBV) and plasma viscosity (PV),
and reduce hematocrit (Hct). In addition, the oxidative stress
state of kidney in NS rats was considerably reversed by
curcumin, which may be achieved by activating Nrf2 and
increasing the expression of antioxidant enzymes HO-1, NQO-1. We
also found that NF-κB pathway is activated in the kidney of NS
rats, and curcumin can inhibit the activation of NF-κB by
down-regulating the expression of NF-κB p65, reducing the level
of p-IκBα and up-regulating the expression of IκBα. These
findings suggest that curcumin, as a multifunctional agent,
exerts a protective effect on DOX-induced nephrotic syndrome in
rats, which provides a pharmacological basis for the further
development of curcumin and also provides a basis for the
advantages of multi-targeted drugs in the processing of NS.
Herbs That Help Alleviate Symptoms Of Chronic
Obstructive Pulmonary Disease
ibtimes,
January 2020 Turmeric contains a compound called curcumin
which helps reduce airway inflammations. Curcumin is a very
powerful antioxidant that helps combat oxidative stress
underlying COPD by blocking inflammation at a molecular level. A
2009 study has reported that curcumin inhibits COPD-like airway
inflammation and the progression of lung cancer. The findings of
the study demonstrated that curcumin can be used to inhibit the
progression of lung cancer in high-risk COPD patients. Several
other pieces of research have pointed to curcumin’s antiviral,
anti-inflammatory and antioxidant effects. This herb’s potential
ability to fight or prevent cancer is intriguing.
Nutraceutical Activities of Turmeric (Curcuma longa)
and its Bioactive Constituent Curcumin Department of Biochemistry, CSIR, December 2019 In the past
couple of decades, many health beneficial physiological effects
of turmeric or its constituent ─ curcumin have been documented
in experimental and/or clinical studies which suggest that
consumption of this spice offers benefits beyond sensory
attributes. Turmeric and curcumin have been shown to exert
preventive and ameliorative influence on diabetes,
cardiovascular disease, inflammatory disorders, and cancer. The
antioxidant property of turmeric/ curcumin explains its diverse
pharmacological potential. Curcumin effectively reduces lipid
peroxidation through its antioxidant influence. Turmeric is
traditionally employed as an anti-inflammatory drug.
Experimental research indicates that curcumin suppresses both
tumour initiation and promotion. The anticarcinogenic effect of
curcumin is mediated through inhibition of the transcription
factor NFkB and proinflammatory pathways. Curcumin induces
apoptosis, and suppresses tumour proliferation and angiogenesis.
The anticancer potential of curcumin is also evidenced in
clinical studies.
"Curcumin supplementation modulated the gut microbiota
composition and ameliorated intestinal dysbiosis by decreasing
the ratio of Firmicutes/Bacteroidetes and endotoxin-producing
Desulfovibrio bacteria and increasing the abundance of
Akkermansia population and SCFA-producing bacteria,
such as Bacteroides, Parabacteroides, Alistipes and
Alloprevotella, along with increases in caecal and colonic
SCFA concentrations. These dominant bacterial genera altered by
curcumin showed strong correlations with the obesity-related
metabolic parameters in HFD-fed mice. In conclusion, our data
suggest that curcumin alleviated metabolic features of hepatic
steatosis and insulin resistance in HFD-fed obese mice, which
might be associated with the modulation of gut microbiota
composition and metabolites." -
Curcumin alleviates high-fat diet-induced hepatic steatosis and
obesity in association with modulation of gut microbiota in mice
| May 2021
"After oral administration, curcumin is distributed in the
intestines, and then curcumin exerts its effects on the gut
microbiota (such as microbial richness, diversity, and
composition). Curcumin administration exerts significant effects on gut
microbiota family such as Bacteroidaceae, Rikenellaceae,
and Prevotellaceae. Moreover, curcumin significantly promoted gut microbiota,
including Anaerotruncus, Exiguobacterium, Helicobacter,
Papillibacter, Pseudomonas, Serratia, and Shewanella. Curcumin
also ameliorates the intestinal barrier function (by modulating
intracellular signaling and the organization of tight junctions)
in metabolic diseases, as indicated by a reduced rate of
bacterial translocation to the blood, liver, kidneys, and
spleen. A study showed that administration of curcumin
significantly reduced the Western-diet-induced blood
lipopolysaccharide and ameliorated the intestinal barrier. Thus,
it can be concluded that curcumin prevents metabolic diseases
through a mechanism involved in the regulation of the intestinal
barrier. Many studies suggest that curcumin can actively hinder
intestinal inflammation by modulating the homeostasis of the
gut-brain axis, and could also exhibit neuroprotective
beneficial. Further, curcumin treatment decreases
the microbial abundance of cancer-related species like
Prevotella, Coriobacterales, and Ruminococcus. These help to exhibit antioxidative and
anticancer properties." - Curcumin and
Metabolic Diseases: The Role of Gut Microbiota, Nutrients |
January 2021
"The remarkable effects of curcumin on isolated gut microbiota
may explain the wide range of its beneficial effects. Several
studies showed that curcumin has positive effects on several
diseases by changing the distribution of some gut microbiota.
This may be an important mechanism underlying therapeutic
benefits of curcumin." -
Does Curcumin
Have a Role in the Interaction between Gut Microbiota and
Schistosoma mansoni in Mice, Pathogens | September 2020
"Curcumin could exert direct
regulative effects primarily in the gastrointestinal tract,
where high concentrations of this polyphenol have been detected
after oral administration. Consequently, it might be
hypothesized that curcumin directly exerts its regulatory
effects on the gut microbiota, thus explaining the paradox
between its low systemic bioavailability and its wide
pharmacological activities. Interestingly, curcumin and its
metabolites have been shown to influence the microbiota. It is
worth noting that from the interaction between curcumin and
microbiota two different phenomena arise: the regulation of
intestinal microflora by curcumin and the biotransformation of
curcumin by gut microbiota, both of them potentially crucial for
curcumin activity." -
Interaction between Gut
Microbiota and Curcumin: A New Key of Understanding for the
Health Effects of Curcumin, Nutrients | July 2020
"Curcumin, an herbal naturally occurring polyphenol, has
recently been proposed for the treatment of neurodegenerative,
neurological and cancer diseases due to its pleiotropic effect.
Recent studies indicated that gut microflora may be a new
potential therapeutic target. The new working hypothesis that
could explain the curative role of curcumin, despite its limited
availability, is that curcumin acts indirectly on the brain,
affecting the “gut–brain–microflora axis”, a complex two-way
system in which the gut microbiome and its composition, are
factors that preserve and determine brain health. It is
therefore suspected that curcumin and its metabolites have a
direct regulatory effect on gut microflora and vice versa, which
may explain the paradox between curcumin’s poor bioavailability
and its commonly reported therapeutic effects. Curcumin and its
metabolites can have health benefits by eliminating intestinal
microflora dysbiosis. In addition, curcumin undergoes enzymatic
modifications by bacteria, forming pharmacologically more active
metabolites than their parent, curcumin. Curcumin is present in
high concentrations in the gastrointestinal tract after oral
administration. Given the pathogenic links between intestinal
microflora and many diseases, current findings could help us
interpret the therapeutic advantage of curcumin." -
Mutual Two-Way Interactions of Curcumin and Gut Microbiota, The
International Journal of Molecular Sciences | February 2020
"The present study demonstrated that curcumin could interact
with gut microbiota in two directions. On one hand, curcumin
exerted direct influence on the gut microbiota of curcumin, and
it could normalize especially the relative abundance of several
key bacterial taxa involved in Alzheimer’s disease development.
On the other hand, gut microbiota could biotransform curcumin
into a series of metabolites, which had been reported to possess
neuroprotective effects. The findings not only interpreted the
paradox between the pharmacological effect of curcumin and its
poor bioavailability, but also implied that metabolites of
curcumin biotansformed by gut microbiota might act as an
important source to screen biologically active compounds to
combat Alzheimer’s disease. Further, the interaction between
curcumin and gut microbiota provided clues to elucidate the
pharmacology of natural polyphenolic compounds, which was worthy
of further study" -
Bidirectional interactions
between curcumin and gut microbiota, Applied Microbiology and
Biotechnology | February 2020
"Curcumin represents one of the most studied herbal remedies, responsible
for different pharmacological activities. The paradox of
poor bioavailability of curcumin and the wide range of health
effects of curcumin can be explained by considering the
reciprocal influence existing between curcumin and gut
microbiota. Curcumin in the gut favors the growth of beneficial
bacteria strains such as Bifidobacteria and Lactobacilli, with
reduction of pathogenic strains. In addition, curcumin
treatment has been found to decrease the microbial richness and
diversity, with a specific reduction of species found as
cancer-related. Several studies reported that curcumin
actively reduces intestinal inflammation by modulating different
molecular pathways. Thus, it is possible that curcumin, by
modulating the homeostasis of the gut–brain axis, could also
determine neuroprotective beneficial effects. To address its
pharmacological and therapeutic advantages, it is fundamental to
consider curcumin interplay with gut microbiota that might pave
the way to fill the gap between the low bioavailability and the
wide health effects. Curcumin can influence gut microbiota composition, allowing the
growth of strains needed to maintain correct host physiologic
functions. This is the case of neurodegenerative diseases in
which often a gut dysbiosis precedes the onset of the clinical
signs. The results
summarized in the review suggest that curcumin alone can exert a
neuroprotective function by affecting different
neuropathological pathways."-
Curcumin, Gut Microbiota, and Neuroprotection, Nutrients |
December 2019
"Bioavailability
of curcumin is not an issue. The therapeutic efficacy of
curcumin as evident from numerous clinical trials overpowers the
hindrance of low bioavailability. Over 200
clinical studies with curcumin have demonstrated the pronounced
protective role of this compound against cardiovascular
diseases, inflammatory diseases, metabolic diseases,
neurological diseases, skin diseases, liver diseases, various
types of cancer, etc. The therapeutic potential of curcumin, as
demonstrated by clinical trials has overpowered the myth that
poor bioavailability of curcumin poses a problem. Low curcumin
bioavailability in certain studies has been addressed by using
higher concentrations of curcumin within nontoxic limits. Hence,
bioavailability is not a problem in the curcumin-mediated
treatment of chronic diseases. Therefore, this golden
nutraceutical presents a safe, low-cost and effective treatment
modality for different chronic diseases." -
Is
curcumin bioavailability a problem in humans: lessons from
clinical trials, Drug Metabolism Toxicology | September 2019
"In recent years, an exponentially increasing number of studies
has indicated that the alterations in the intestinal microbiota
are linked with many metabolic diseases, including obesity,
diabetes, and chronic liver disease, and the intestinal
microbiota is proposed to be a novel potential therapeutic
target for these microbiota-associated diseases. Although
curcumin has poor systemic bioavailability, after oral
administration it is expected to be present in high
concentrations in the gastrointestinal tract. Thus, it is
rational to infer that curcumin may exert direct regulative
effects on the gut microbiota. This may be an important
mechanism underlying its therapeutic benefits and could explain
the paradox between curcumin’s poor systemic bioavailability and
its widely reported pharmacological activities." - Regulative effects of curcumin spice administration on gut
microbiota and its pharmacological implications, Food &
Nutrition Research | August 2019
"The bioavailability of the parent curcumin compound is low, but
oral administration of curcumin can still deliver detectable
levels of curcumin glucuronide metabolite. Despite the absence
of the parent curcumin in the blood/plasma, the antioxidant and
epigenetic modulatory effects of curcumin glucuronide can
explain the potential overall health beneficial effect of this
herbal medicinal product. Thus, it is reasonable to believe that
most of the curcumin effects in vivo may be due to local and
direct effects rather than systemic effects of this turmeric
compound after absorption. This suggests there may be potential
health benefits of taking curcumin and challenges negative
perceptions on the lack of health benefit or efficacy of taking
oral curcumin. In conclusion, the results of our current
study are highly relevant to the over-the-counter use of
botanical curcumin in a real-world scenario." -
Pharmacokinetics, pharmacodynamics and PKPD modeling of curcumin
in regulating antioxidant and epigenetic gene expression in
human healthy volunteers, Molecular Pharmaceutics | March 2019
"Effects of Curcumin on Gut Microbiota | Given the low systemic
bioavailability of curcumin and its pharmacological therapeutic
uses, curcumin might provide benefit by acting on gut
microbiota. This impact on the gut microbiota seems to be
reasonable and attractable areas of study as no absorption of
the parent compound is necessary. It is suspected that curcumin
could exert direct regulative effects on the gut microbiota
which could explain the paradox between curcumin's poor systemic
bioavailability and its widely reported pharmacological effects.
There is some indication that curcumin may act as promoting
factors of growth, proliferation, or survival for beneficial
members of the gut microbiota, and is able to modulate gut
microbial composition (i.e., biodiversity). It is suggested that
healthy ageing correlates with microbiome diversity. The
administration of curcumin significantly shifted the ratio
between beneficial and pathogenic microbiota by increasing the
abundance of bifidobacteria, lactobacilli, and
butyrate-producing bacteria and reducing the loads of Prevotellaceae,
Coriobacterales, enterobacteria, and enterococci. Curcumin, through
impacts on the microbiota, might positively influence certain
organismal functions. By modulating the microbiome, curcumin may
reduce some adverse consequences of ageing, and the impact of
curcumin on the microbiome seems to be very promising in the
context of the modulation of the ageing process. These
alterations in gut microbiota could also explain the immune
modulation and antihyperlipidemia efficacy of curcumin aside of
its anti-inflammatory and anticolonotropic carcinogenicity
activity. Effects of Gut Microbiota on Curcumin | The
composition of gut microbiota had a profound influence on the
biotransformation of curcumin in the colon by various processes
mainly by reduction followed by conjugation, which might have a
significant impact on the health effects of dietary curcumin,
especially in the GI. Data suggests that intestinal bacteria
produce a high amount of β-glucuronidase that can elevate the
level of free compounds. Microbiota can be responsible for drug
metabolism and, by their ability to metabolize curcumin, can
regulate its bioavailability." -
Gut Microbiota as a
Prospective Therapeutic Target for Curcumin: A Review of Mutual
Influence, Journal of Nutrition and Metabolism | December 2018
"Curcumin
has anti-inflammatory, anti-oxidant and anti-proliferative
properties established largely by in vitro studies. Accordingly,
oral administration of curcumin beneficially modulates many
diseases including diabetes, fatty-liver disease,
atherosclerosis, arthritis, cancer and neurological disorders
such as depression, Alzheimer's or Parkinson's disease. We
established curcumin-mediated decrease in the release of gut
bacteria-derived lipopolysaccharide (LPS) into circulation by
maintaining the integrity of the intestinal barrier function as
the mechanism underlying the attenuation of metabolic diseases
(diabetes, atherosclerosis, kidney disease) by curcumin
supplementation precluding the need for curcumin absorption. In
view of the causative role of circulating LPS and resulting
chronic inflammation in the development of diseases listed
above, this review summarizes the mechanism by which curcumin
affects the several layers of the intestinal barrier and,
despite negligible absorption, can beneficially modulate these
diseases." - Curcumin-mediated regulation of
intestinal barrier function: The mechanism underlying its
beneficial effects, Tissue Barriers | February 2018
"Curcumin was a potent anti-helicobacter pylori agent
in vivo and in vitro. Curcumin could partially
reverse changes in the diversity of the gut microbiota and could
lower the increasing abundance of the genera Anaerotruncus
and Helicobacter in the gut of model rats."
-
Effect of Curcumin on the Diversity of Gut Microbiota in
Ovariectomized Rats, Nutrients | October 2017
"Studies provide evidence that despite low bioavailability, oral
curcumin likely mediates its anti-inflammatory (and
inflammation-dependent downstream effects) by its local action
in the gut. Studies from our laboratory demonstrated the potent
effects of oral supplementation with curcumin on the development
of glucose intolerance and atherosclerosis. Furthermore,
curcumin supplementation attenuated increase in plasma
lipopolysaccharide levels by not only increasing the activity of
intestinal alkaline phosphatase that detoxifies
lipopolysaccharide in the gut lumen but also by improving
intestinal barrier function. The data presented herein
establishes the intracellular mechanisms by which curcumin
improves the intestinal barrier. Apical or luminal exposure to
curcumin might underlie its observed effects on improvement of
intestinal barrier function by oral administration. The major
site of action of curcumin is the intestinal epithelial cells
and the intestinal barrier, and by reducing intestinal barrier
dysfunction, curcumin modulates chronic inflammatory diseases
despite poor bioavailability. Reduced intracellular IL-1β
signaling and subsequent reduction in disruption of tight
junctions represent the mechanisms underlying the beneficial
effects of oral curcumin, despite its poor bioavailability. The
causal relationship between curcumin exposure of intestinal
epithelial cells and inflammatory bowel diseases is
straightforward and is not affected by the issue of poor
bioavailability, and oral curcumin is currently being considered
as a therapeutic agent for inflammatory bowel disease. Curcumin
is expected to not only reduce local inflammation in the gut,
but by altering intestinal barrier function it will also reduce
systemic inflammation triggered by the release of
lipopolysaccharide into circulation." -
Curcumin improves intestinal barrier
function: modulation of intracellular signaling, and
organization of tight junctions, American Journal of Physiology
Cell Physiology | April 2017
"Metabolites of curcumin are present in high concentrations in
the circulation after curcumin consumption. These curcumin
metabolites may be responsible for the anti-inflammatory and
antioxidant activities that reduce the symptoms of metabolic
diseases including osteoarthritis. Curcumin is detectable in the circulation
as the forms of glucuronide and sulfate conjugates in the
patients with oral consumption of 8 g/day curcumin for more than
2 months. Thus, curcumin itself can be a therapeutic agent for
relieving arthritis." -
Efficacy of Turmeric
Extracts and Curcumin for Alleviating the Symptoms of Joint
Arthritis: A Systematic Review and Meta-Analysis of Randomized
Clinical Trials, Journal of Medicinal Food |August 2016
"Despite a wide range of pharmacological activities of curcumin
reported in the past decades, a paradox remains regarding the
pharmacology of curcumin: how curcumin is able to manifest
remarkable biological effects under the condition of poor
systemic bioavailability. Our novel experimental and theoretical
findings suggested that the degradation products should play
important roles in executing the biological and pharmacological
activities of curcumin. The degradation products of curcumin are
actually the main bioactive molecules in executing the
biological activities of curcumin.Our finding not only provides
a plausible explanation for the seemingly contradictory
observations regarding biological activities of curcumin, it is
also highly significant for the therapeutic application of this
natural product against various human diseases." -
How does curcumin work with poor bioavailability? Clues from
experimental and theoretical studies, Scientific Reports |
February 2016
"The beneficial effect of curcumin on tumorigenesis was
associated with the maintenance of a more diverse colonic
microbial ecology.These chemopreventive effects appeared
unrelated to the reduction of inflammation, but rather to the
normalizing effects of curcumin on colonic microbial ecology,
thus suggesting that curcumin functions as an effective agent
for restoring healthy gut homeostasis and microbial-host
relationship. We determined that dietary curcumin maintained
high microbial diversity, associated with the expansion of
Lactobacillales (represented mainly by genus Lactobacillus).
Curcumin contributes to chemoprevention via expansion of the
native Lactobacilli in the context of overall increase of
colonic microbiome richness. Curcumin has been observed to
inhibit bacterial motility and cytotoxicity of Vibrio
vulnificus, to arrest Helicobacter pylori growth during
infections, as well as inhibit biofilm formation in
Pseudomonas aeruginosa. This suggests that the protective
effect of 0.5% curcumin diet shifts the microbial composition to
be more stationary, which may contribute to a decrease in
microbial invasiveness and a decrease in overall disease
severity. We demonstrated efficacy of curcumin on inflammation
associated colorectal cancer and normalizing effects of colonic
microbial ecology. Curcumin may represent a promising approach
to chemoprevention in IBD. " -
The Role of Curcumin
in Modulating Colonic Microbiota During Colitis and Colon Cancer
Prevention, Inflammatory Bowel Diseases | November 2015
"Curcumin treatment exerted a significant anti-inflammatory
effect in H. pylori-infected mucosa, pointing to the
promising role of a nutritional approach in the prevention of
H. pylori induced deleterious inflammation. Curcumin
may be a potential agent for controlling inflammation associated
with H. pylori infection. The aim of the present study
is to evaluate the anti-inflammatory effect of curcumin using
the experimental model of H. pylori chronic infection.
Curcumin was effective in reducing the inflammation of the
gastric mucosa of H. pylori-infected mice, which was
confirmed at the molecular level. At this level the magnitude of
the difference in the expression of the inflammatory mediators’
encoding genes between the infected curcumin-treated mice and
the infected but non-treated ones strongly supports the powerful
anti-inflammatory properties of curcumin. Curcumin acted two
ways during protection against H. pylori infection,
i.e. by eradicating H. pylori as well as potentially
targeting key molecules involved in the H. pylori-induced
gastric diseases. This is one of the few studies using both
histological and molecular approaches, showing the important
anti-inflammatory role of curcumin in the context of chronic H. pylori
infection. Taking into account the extensive
consumption of polyphenols in the human diet (curcumin and
others), our data points to the promising role of a nutritional
approach in the control of H. pylori induced
deleterious inflammation." -
Curcumin Inhibits
Gastric Inflammation Induced by Helicobacter Pylori Infection in
a Mouse Model, Nutrients | January 2015
"Curcumin exerts potent effects in reducing metabolic diseases
such as diabetes and atherosclerosis by modulating the
intestinal barrier function, precluding the need for effective
absorption and systemic bioavailability.The significant
reduction in glucose intolerance as well as atherosclerosis by
oral curcumin demonstrates the importance of targeted
improvement in intestinal barrier function as a potential
therapeutic strategy. This represents a change in the existing
paradigm and places the focus on improving intestinal barrier
function rather than direct modulation of gut bacteria itself.
In conclusion, the data presented here provide direct evidence
for the role of Western diet-induced disruption of intestinal
barrier function in the development of metabolic diseases such
as diabetes and atherosclerosis. Furthermore, these studies also
identify curcumin as an agent effective in restoring the
intestinal barrier function by modulating multiple components of
this barrier including IAP and paracellular permeability. Future
studies will examine the effects of curcumin on other components
of the intestinal barrier to further advance our current
understanding and to develop curcumin as a dietary supplement to
attenuate multiple inflammation-linked diseases." -
Oral Supplementation with Curcumin Attenuates Western
Diet-Induced Atherosclerosis and Glucose Intolerance | Role of
Intestinal Permeability and Macrophage Activation, PLoS One |
September 2014
"Our experiments show that curcumin supplementation can suppress
H. pylori-induced gastric inflammation, as indicated by
decreased NF-κB p65 expression in gastric epithelial cells and
decreased macromolecular leakage in the gastric
microcirculation. Curcumin decreased these parameters,
indicating that curcumin could decrease gastric inflammation.
Curcumin supplementation may exert its anti-inflammatory effect
by reducing macromolecular leakage through the suppression of
NF-κB p65 expression in gastric epithelial cells. Hence,
curcumin might be a novel therapeutic strategy against gastric
inflammation." -
Curcumin suppresses gastric NF-κB
activation and macromolecular leakage in Helicobacter
pylori-infected rats, World Journal of Gastroenterology | August
2010
"Curcumin is biotransformed in the intestinal tract of humans.
Curcumin is a large lipophilic molecule that undergoes extensive
gastrointestinal and hepatic metabolism after oral dosing. Phase
I metabolism is through a reduction reaction forming
tetra-hydrocurcumin, hexahydrocurcumin, and
hexa-hydrocurcuminol. Phase II metabolism consists of
glucouronidation and sulfation by O-conjugation to form curcumin
glucuronide and curcumin sulfate. Gut
metabolism contributes substantially to the overall metabolite
yield generated from curcumin in vivo. The
pharmacological implications of the intestinal metabolism of
curcumin should be taken into account in the design of future
chemoprevention trials of this dietary constituent."
-
Metabolism of the Cancer Chemopreventive Agent Curcumin in
Human and Rat Intestine, Cancer Epidemiology, Biomarkers &
Prevention | January 2002
n most studies Curcumin 95% has been delivered orally whether
the subject is human or animals. This orally delivered Curcumin 95% extract
showed antioxidant, anti-inflammatory, antidiabetic, and anticancer
beneficial effects. Oral curcumin efficacy in vivo has been shown in models for
many conditions with oxidative damage and inflammation,
including many types of cancer, diabetes, atherosclerosis,
arthritis, stroke, peripheral neuropathy, inflammatory bowel,
and brain trauma. Curcumin is fat-soluble, so when
combined with healthy fats and oils, the body can absorb it
better because curcumin is directly absorbed into the
bloodstream through the lymphatic system thereby in part
bypassing the liver.
A
traditional method of dissolving curcumin in fat is likely an
effective method to improve absorption. You can
also ensure you are absorbing the maximum amount by consuming
curcumin with fats from meat, fish, dairy, olive oil, coconut oil
and others.
"In vitro
and in vivo studies have confirmed
the activity of curcumin in biological system by either
detecting curcumin or its bio-transformed metabolites in plasma,
peripheral organs and brain." -
bioRxiv
"Clinical trials have
shown that orally delivered curcumin inhibited inflammatory molecules."
-
AAPS Journal
"Levels of curcumin and its metabolites in plasma, urine, and
feces were analyzed by high-pressure liquid chromatography and
mass spectrometry. A daily dose of 3.6g curcumin
engendered 62% and 57% decreases in inducible PGE2 production in
blood samples taken 1 hour after dose on days 1 and 29,
respectively, of treatment compared with levels observed
immediately predose (P < 0.05). A daily oral dose of 3.6g of
curcumin is advocated for Phase II evaluation in the prevention
or treatment of cancers outside the gastrointestinal tract. PGE2
production in blood and target tissue may indicate biological
activity. Levels of curcumin and its metabolites in the urine
can be used to assess general compliance." -
Clinical
Cancer Research
"Oral
curcumin,
6.0 g daily during radiotherapy, reduced the severity of radiation
dermatitis in breast cancer patients." -
Radiation Research
"Curcumin mixed with the diet achieves drug levels in the
colon and liver sufficient to explain the pharmacological
activities observed and suggest that this mode of
administration may be preferable for the chemoprevention of
colon cancer. The colon mucosal level of curcumin after 14
days feeding observed in this study, 1.8 μmol/g, is more
than 300-fold higher than the minimal concentration shown to
be active in vitro. This result demonstrates that dietary
administration of curcumin can produce pharmacologically
relevant drug concentrations in colon mucosa. Our results
therefore intimate that dietary curcumin at doses
considerably lower than those used here might yield
pharmacologically efficacious levels in the colon mucosa and
perhaps also in the liver. The M1G-lowering effect of
curcumin provides a tentative rationale for the regular use
of dietary curcumin in the protection of the colon mucosa
against oxidative damage, perhaps in premalignant conditions
such as ulcerative colitis. Dietary administration of
curcumin to rats produces pharmacologically active levels of
unmetabolized curcumin in the colon mucosa and liver,
capable of decreasing M1G levels and elevating GST activity.
These effects may contribute to cancer chemoprevention. The
results also suggest that dietary admixture may be the
preferable mode of administration for curcumin in the
chemoprevention of colon cancer. The chemopreventive
efficacy of oral curcumin in the colorectum and the liver
merits clinical evaluation." -
Effects of Dietary
Curcumin on Glutathione S-Transferase and
Malondialdehyde-DNA Adducts in Rat Liver and Colon Mucosa,
Experimental Therapeutics, Preclinical Pharmacology
"Oral administration
of 90 mg of curcumin or the placebo 2 hours before exercise and immediately
after exercise. Curcumin supplementation attenuated exercise-induced oxidative
stress by increasing blood antioxidant capacity." -
Int J Sports Med.
"In animal oral
administration, Curcumin inhibited
lung cancer,
skin cancer,
head and neck
cancer,
oral cancer,
hepatocellular carcinoma,
mammary tumors,
lymphomas, leukemias, and
familial
adenomatous polyposis." - Cancer Res Treat.
"Oral treatment of
curcumin found to effective in diabetic condtion. It attenuated high fat
diet-induced glucose intolerance and elevations of oxidative stress in the
skeletal muscle." -
World J Diabetes
"Curcumin was effective both
orally and topically. These results show that curcumin
enhanced wound repair in diabetic impaired healing, and
could be developed as a pharmacological agent in such
clinical settings."
-
Wound Repair
Regen
"Our findings indicate that
curcumin is a potent anti-inflammatory agent that prevents
the release of TNFα and protects against the pulmonary and
cardiovascular effects of DEP." -
PLoS
One"In a human clinical
trial, 3.6 g of Curcumin via oral route was found to produce a plasma curcumin
level of 11.1 nmol/L after an hour of dosing." -
Clinical Cancer Research
"The average peak serum concentrations after taking
4,000 mg, 6,000 mg and 8,000 mg of curcumin were 0.51 microM, 0.63 microM and
1.77 microM, respectively."
-
Phase I Clinical Trial of Curcumin,
Anticancer Research
"Traces of curcumin
were detected in the plasma. Its concentration in the small intestinal mucosa,
between 39 and 240 nmol/g of tissue, reflects differences in dietary
concentration...The comparison of dose, resulting curcumin levels in the
intestinal tract, and chemopreventive potency suggests tentatively that a daily
dose of 1.6 g of curcumin is required for efficacy in humans." -
Journal Cancer
Epidemiol Biomarkers
"The concentrations of
curcumin in normal and malignant colorectal tissue of patients receiving
3,600 mg of curcumin were 12.7 +/- 5.7 and 7.7 +/- 1.8 nmol/g,
respectively...The results suggest that a daily dose of 3.6 g curcumin
achieves pharmacologically efficacious levels in the colorectum with
negligible distribution of curcumin outside the gut."
-
Cancer Epidemiol Biomarkers
"One hour after administration, the levels of curcumin in the intestines,
spleen, liver, and kidneys were 177.04, 26.06, 26.90, and 7.51 microg/g,
respectively." -
Journal Drug Metab Dispos.
"Bromelain (pineapple extract) substantially promotes the
absorption of curcumin enhancing its bioavailability, and
making this a perfect combination of immune-boosting
nutraceuticals with synergistic anti-inflammatory and
anticoagulant actions." -
Metabolism
"Buttermilk
could be used as a carrier for curcuminoids especially if
delivered with food...The most important and practical
finding from the bioaccessibility data is that the
incorporation of powdered curcuminoids with buttermilk
results in a 15-fold increase in bioaccessibility of
curcuminoids."
-
Food Chemistry
"Curcumin was found in plasma (16.1 ng/mL), urine (2.0 ng/mL),
intestinal mucosa (1.4 mg/g), liver (3,671.8 ng/g), kidney (206.8 ng/g), and
heart (807.6 ng/g)." -
Journal Agric Food Chem.
"Curcuminoids were
detectable in plasma samples, urine samples, and in the
colonic mucosa of all 23 biopsied participants. Mean tissue levels were 48.4
μg/g (127.8 nmol/g) of parent curcuminoids. The major conjugate, curcumin
glucuronide, was detectable in 29 of 35 biopsies. High levels of topical
curcumin persisted in the mucosa for up to 40 hours postadministration. In
summary, pharmacologically active levels of curcumin were recovered from
colonic mucosa. The regimen used here seems safe, and patients support its
use in long-term trials." -
Cancer Prev Res.
"After oral
administration of 400 mg Curcumin to rats, about 60% of the dose was
absorbed." -
Journal Toxicology
"Tissue
distribution of Curcumin using tritium-labeled drug. They found that
radioactivity was detectable in blood, liver, and kidney following doses of
400, 80, or 10 mg of [3H] curcumin. With 400 mg, considerable
amount of radio labeled products were present in tissues 12 days after
dosing. The percentage of curcumin absorbed (60-66% of the given dose)
remained constant." -
Journal Toxicology
Curcumin rescues breast cells
International
Journal of Oncology, December 2019 Breast cancer is the most
prevalent type of cancer among women worldwide and it is
characterized by a high morbidity. Curcumin is a naturally
occurring compound derived from the rhizome of Curcuma longa and
is known to have antioxidant and anticarcinogenic properties.
Curcumin also acted upon the miRNA as a regulator of genes
implicated in EMT and upon Rho‑A as well, affecting the
migration and invasion of the cells. This occurred independently
of their estrogen receptor (ER), progesterone receptor (PgR) and
human epidermal growth factor receptor 2 (HER2) receptors in the
non‑malignant MCF‑10F and malignant MDA‑MB‑231 breast cell
lines, which are both negative for such receptors.
Turmeric and Inflammatory Diseases: An Overview of
Clinical Evidence Department of Traditional
Pharmacy, December 2019 Turmeric (Curcuma longa L.) and its
major ingredients, curcuminoids, are the well-known natural
products used for the management of several inflammatory
conditions including inflammatory bowel diseases, irritable
bowel syndrome, osteoarthritis, rheumatoid arthritis, renal
diseases, oral lichen planus, gingivitis and periodontitis,
radiation-induced oral mucositis and dermatitis, psoriasis, and
respiratory problems. Main inflammatory markers in chronic
inflammation include C-reactive protein, tumor necrosis
factor-α, and different interleukins which are assessed in the
clinical trials. Turmeric and curcumin have demonstrated
significant effect in some clinical trials.
Effect of Curcumin on the Diversity of Gut
Microbiota Department of Analytical and
Food Chemistry, December 2019 Curcumin, the main active
component of turmeric (Curcuma longa), is widely used as a
flavoring and coloring agent in food, and also exhibits multiple
pharmacological activities. It has been traditionally used in
Asian countries as a medical herb for several pathologies due to
its anti-inflammatory, antioxidant, antimicrobial,
antimutagenic, and anticancer properties. Further, curcumin may
potentially complement the conventional treatment of insulin
resistant conditions, including obesity, pre-diabetes, metabolic
syndrome, and type II diabetes. Recently, its potential utility
in Auto-Immune Deficiency Syndrome (AIDS) had been demonstrated.
Antibacterial and Anticancer Activities of Turmeric
and its Active Ingredient Curcumin Department of Biotechnology, Institute of Biosciences and
Biotechnology, December 2019 Turmeric (Curcuma longa)
contains curcuminoids, and various sesquiterpenes which
contributes towards a wide array of biological activities, e.g.
anti-inflammatory, wound healing, anticancer, and antibacterial
activities. Curcuminoids and sesquiterpenes are the main
constituents of turmeric, for which a plethora of molecular
targets, and pharmacological activities have been reported. The
most studied activity of the curcuminoids present in turmeric in
the recent year is the anticarcinogenic activity. Experiments
have shown that curcuminoids modify the gene expression of
cancer related markers. Curcumin has the potential to regulate
genes related to cell division, cell cycle regulation, and
apoptosis. The anticarcinogenic activity of turmeric has been
studied in case of lung, breast, prostate, ovarian, colorectal
cancers, leukemia, and multiple myelomas. Turmeric significantly
inhibits benzopyrene induced forestomach papillomas. Dietary
turmeric, along with catechin, is a chemoprotective agent.
Besides anticarcinogenic effect, the antibacterial activity of
turmeric against various bacteria, such as Streptococcus
aureus, Trichophyton gypseum, Salmonella paratyphi, and
Mycobacterium tuberculosis has also been explored. The
active ingredients of turmeric can be used as lead compounds to
design potential drugs for the treatment of different types of
bacterial diseases and cancers.
Curcumin, Gut Microbiota, and Neuroprotection
Nutrients, December 2019 Curcumin, a nontoxic, naturally
occurring polyphenol, has been recently proposed for the
management of neurodegenerative and neurological diseases. It is
possible that curcumin could exert direct regulative effects
primarily in the gastrointestinal tract, where high
concentrations of curcumin are present after oral
administration. Indeed, a new working hypothesis that could
explain the neuroprotective role of curcumin despite its limited
availability is that curcumin acts indirectly on the central
nervous system by influencing the “microbiota–gut–brain axis”, a
complex bidirectional system in which the microbiome and its
composition represent a factor which preserves and determines
brain “health”. Interestingly, curcumin and its metabolites
might provide benefit by restoring dysbiosis of gut microbiome.
Conversely, curcumin is subject to bacterial enzymatic
modifications, forming pharmacologically more active metabolites
than curcumin. These mutual interactions allow to keep proper
individual physiologic functions and play a key role in
neuroprotection.
Can curcumin reduce cardiovascular risk factors? Examine.com, December 2019 Curcumin is thought to have
multiple possible health benefits. This meta-analysis zeros in
on its effects on cardiovascular risk factors. Cardiovascular
disease (CVD) is the number one cause of death in the U.S., but
some of the risk factors for CVD are modifiable. One of the most
well-known risk factors are serum lipid levels, in particular
LDL cholesterol and triglycerides. Researchers and
healthcare practitioners alike are therefore interested in the
potential properties of turmeric, and more specifically its
active ingredient curcumin, for possible anti-inflammatory and
lipid-lowering effects. Curcumin has long been touted[2] as
having medicinal benefits, and the safety of curcumin, even at
high doses[3], has been consistently demonstrated. Curcumin is a
polyphenol shown in preclinical and clinical research to have
anti-inflammatory[4] properties and its effects have been
studied in people with numerous disease states[5][6][7]. In
studies examining the effects of supplemental curcumin on
participants with cancer, those receiving supplementation showed
reduced levels of numerous proinflammatory biomarkers.
Turmeric can help treat oral cancers u4uvoice.com, December 2019 HPV is a virus that promotes the
development of cervical and oral cancer. There is no cure, but
the new findings suggest that curcumin may offer a means of
future control. Mishra’s research group first noted the effect
of curcumin on HPV and cervical cancer cells in 2005. The
antioxidant slowed the expression of HPV, suggesting that
curcumin could control the extent of HPV infection. “Since
HPV-related oral cancer cases are on the rise, we tested the
same hypothesis on oral cancer,” Mishra explained. “They turned
out to be some very interesting findings.” The new research
indicates that curcumin turns down the expression of HPV in
infected oral cancer cells by downregulating the levels of
cellular transcription factors AP-1 and NF-kB.
How to live longer: Five diet tips to prevent
disease and boost life expectancy
Express,
December 2019 Curcumin, found in turmeric, is believed to
give the yellow spice its health properties, and studies have
linked it to improved brain function, lower risk of heart
disease and even cancer prevention. Turmeric is renowned
for its anti-inflammatory properties. Curcumin has also been
linked to an increased lifespan in both insects and mice.
Curcumin May Help Prevent or Combat Stomach Cancer,
Study Finds Yoga Esoteric, December 2019 Curcumin – derived from the turmeric plant (Curcuma longa) – has
been used to impart color and flavor to food in many areas of
the world. But long ago, scientists discovered that the bright,
yellow powder can also help prevent and fight stomach cancer. In
a study conducted by researchers at the Federal University of
São Paulo (UNIFESP) and the Federal University of Pará (UFPA) in
Brazil, the possible therapeutic effects of the pigment were
identified. The study was part of a Thematic Project supported
by São Paulo Research Foundation, or FAPESP. The findings have
been published in the journal Epigenomics. “We undertook a vast
review of the scientific literature on all nutrients and
bioactive compounds with the potential to prevent or treat
stomach cancer and found that curcumin is one of them,” said
Danielle Queiroz Calcagno, first author of the study and a
professor at UFPA.
The effects of curcumin supplementation on body mass
index, body weight, and waist circumference in patients with
nonalcoholic fatty liver disease Phytotherapy Research, December 2019 Several clinical trials
have examined the effects of curcumin supplementation on
anthropometric variables in NAFLD patients with inconclusive
results. Curcumin supplementation significantly reduced BMI.
These results suggest that curcumin supplementation might have a
positive effect on visceral fat and abdominal obesity that have
been associated with NAFLD.
Herbs to control hypertension and diabetes Times of India, December 2019 Turmeric has a compound known
as curcumin in it, which has shown to control blood sugar levels
as well as prevent the onset of diabetes. In a nine-month-long
study, 240 participants who had pre-diabetes were made to have
curcumin capsules every day. These people did not develop
diabetes by the end of nine months.
Curcumin prevents high-fat diet-induced hepatic
steatosis in ApoE−/− mice by improving intestinal barrier
function and reducing endotoxin and liver TLR4/NF-κB
inflammation Nutrition & Metabolism,
December 2019 Curcumin is a natural polyphenolic compound
present in turmeric and possesses antiinflammatory, antioxidant
and hepatoprotective properties. In recent animal studies,
curcumin has been shown to have a protective effects on the
liver against fat accumulation induced by a high-fat diet. The
administration of curcumin significantly prevented HFD-induced
body weight gain and reduced liver weight. Curcumin attenuated
hepatic steatosis along with improved serum lipid profile.
Moreover, curcumin up-regulated the expression of intestinal
tight junction protein zonula occluden-1 and occludin, which
further improved gut barrier dysfunction and reduced circulating
lipopolysaccharide levels. Curcumin also markedly down-regulated
the protein expression of hepatic TLR4 and myeloid
differentiation factor 88 (MyD88), inhibited p65 nuclear
translocation and DNA binding activity of nuclear factor-κB
(NF-κB) in the liver. In addition, the mRNA expression of
hepatic tumour necrosis factor-α (TNF-α) and interleukin-1β
(IL-1β) as well as the plasma levels of TNF-α and IL-1β were
also lowered by curcumin treatment. These results indicated that
curcumin protects against HFD-induced hepatic steatosis by
improving intestinal barrier function and reducing endotoxin and
liver TLR4/NF-κB inflammation. The ability of curcumin to
inhibit hepatic steatosis portrayed its potential as effective
dietry intervention for non-alcoholic fatty liver disease
(NAFLD) prevention.
Foods
that Can Help Students Regulate Blood Sugar and Prevent Diabetes University Herald, December 2019 Turmeric -has the most
important content called curcumin. It can help reduce blood
sugar levels and inflammation while protecting against heart and
kidney disease. Curcumin appears to benefit kidney health in
diabetics, thus it is important to also include this on your
diet because diabetes is one causes of kidney diseases.
Want to Have a Slim Body? These Kitchen Ingredients
Can Help You India.com, December 2019 Containing a significant compound called curcumin, turmeric can
prevent you from becoming obese. It can do so by increasing your
body’s metabolism rate. Also, it helps in fighting against
debilitating conditions like cancer and Alzheimer’s disease.
Neuroprotective and Neurological/Cognitive
Enhancement Effects of Curcumin after Brain Ischemia Injury with
Alzheimer’s Disease International Journal
of Molecular Sciences, December 2019 Curcumin has several
therapeutic properties that include anti-excitotoxic,
anti-oxidant, anti-apoptotic, anti-hyperhomocysteinemia and
anti-inflammatory effects, mitochondrial protection, as well as
increasing neuronal lifespan and promoting neurogenesis. In
addition, curcumin also exerts anti-amyloidogenic effects and
affects the brain’s tau protein. Accumulating evidence has
clearly shown the role of the neuroprotective and
neurological/cognitive enhancement effects of curcumin after
brain ischemia-reperfusion injury with the phenotype of
Alzheimer’s disease. Based on the data presented, it appears
that curcumin has its own effective therapeutic potential
through anti-amyloid, anti-tau protein hyperphosphorylation,
anti-hyperhomocysteinemia, anti-oxidant, anti-inflammatory, and
anti-apoptotic effects which clearly indicates that curcumin can
be used as a neuroprotective substance not only in ischemic
neurodegeneration but also in a neurodegenerative disease
similar to Alzheimer’s disease as a response to brain ischemia
associated with hyperhomocysteinemia. The available data show
that curcumin induces neuroprotection and neurogenesis and may
be a new therapeutic agent for both regenerative medicine and
for the treatment of neurodegenerative disorders such as
neurodegeneration after brain ischemia with the phenotype of
Alzheimer’s disease. Therefore, curcumin may be a promising
supplementary agent against brain ischemia-reperfusion injury in
the future. Indeed, there is a rational scientific basis for the
use of curcumin for the prophylaxis and treatment of ischemic
neurodegeneration.These results suggest that curcumin may be
able to serve as a potential preventive and therapeutic agent in
neurodegenerative brain disorders.
Foods for maintaining healthy arteries The Saxon, December 2019 Curcumin is an anti-inflammatory
substance. This substance does not allow the arteries to become
hard and accumulate harmful plaque. Turmeric is also rich in
vitamin B6, which prevents damage of blood vessels and prevents
plaque accumulation. And yet, this spice reduces the level of
malicious lipids and reduce the oxidation of cholesterol.
Protection of Curcumin against Streptozocin-Induced
Pancreatic Cell Destruction in T2D Rats Planta Medica, December 2019 As a kind of traditional Chinese
medicine extract, curcumin has been proven to be effective in
inhibiting inflammation and apoptosis in pancreatic islet β
cells in the streptozotocin-induced diabetes mellitus rat model,
although the underlying mechanism has not yet been clarified.
Curcumin administration significantly decreased fasting blood
glucose and promoted recovery of pancreas function in type 2
diabetes rats. In curcumin-treated rats, the pancreatic tissue
destruction and apoptosis index were reduced. The expression of
IL-1β, IL-6, TNF-α, caspase-3, Bax, and malondialdehyde were
significantly reduced, and Bcl-2, superoxide dismutase 2, and
glutathione peroxidase were significantly increased. Curcumin
inhibited the expression of phosphorylated JNK and NF-κB
proteins to block the RAGE/JNK/NF-κB signaling pathway. In
conclusion, these results indicate that curcumin blocks the
phosphorylation of JNK and NF-κB protein to inhibit this
signaling pathway, thereby further inhibiting inflammation and
apoptosis in pancreatic islet β cells. Curcumin has potential
value for the treatment of diabetes.
Potential therapeutic effects of curcumin and niacin
in rotenone-induced Parkinson’s disease mice model Molecular and Cellular Biochemistry, December 2019 Treatment
with curcumin, niacin, adenosine A2AR antagonist; ZM241385 and
their combination enhanced the animals’ behavior and restored
all the selected parameters with variable degrees of
improvement. The brain histopathological features of hippocampal
and substantia nigra regions confirmed our results. In
conclusion, the combination of curcumin, niacin and ZM241385
recorded the most potent treatment effect in Parkinsonism mice
followed by ZM241385, as a single treatment. ZM241385 succeeded
to antagonize adenosine A2A receptor by diminishing its gene
expression and ameliorating all biochemical parameters under
investigation. The newly investigated agent; ZM241385 has almost
the same pattern of improvement as the classical drug; Sinemet®.
This could shed the light to the need of detailed studies on
ZM241385 for its possible role as a promising treatment against
PD. Additionally, food supplements such as curcumin and niacin
were effective in Parkinson’s disease eradication.
The Protective Effect of Curcumin Against
Cisplatin-Induced Nephrotoxicity Experimentally in Rats Archives of Pharmacal Research, December 2019 Curcumin has
renal protective properties against kidney damage. The results
clarified the strong protective effect of curcumin on cisplatin
induced nephrotoxicity in rats at the molecular level. Curcumin
is known for its high oxygen-radical scavenging and quenching
power. It is a scavenger of free oxygen radicals and stimulates
the activity of additional antioxidant molecules such as
superoxide dismutase, catalase, and glutathione peroxidase. It
is a bifunctional antioxidant because of its ability to react
directly with reactive species and to induce an up regulation of
various cytoprotective and antioxidant proteins. Curcumin can
react with ROS through its phenolic and methoxy groups and it is
thought to be one of the mechanisms through which it can protect
the renal epithelial from ROS activity. Curcumin can indirectly
induce the expression of cytoprotective proteins such as
superoxide dismutase. Furthermore, it has been reported that
curcumin can increase the synthesis and concentration of GSH. In
summary, this study demonstrated that curcumin can protect
against nephrotoxic effects of cisplatin in rats. The protective
effect of curcumin occurred through the up regulation of
antioxidants and suppression of oxidative stress markers.
Curcumin is a promising therapy for management of kidney
nephrotoxicity.
Spice Stops Cancer, Study Finds The
Institute for Natural Healing, November 2019 UCLA
researchers found that curcumin activates cancer-fighting
enzymes in patients with head and neck cancers. A 2013 study at
the University of North Texas Health Science Center found that
curcumin suppresses pancreatic cancer tumors. A 2006 study
published in the journal Neuroscience Letters found that
curcumin induces cell death in glioblastoma (brain cancer)
cells. A Chinese study showed that curcumin makes stomach cancer
less resistant to chemotherapy. A study at MD Anderson Cancer
Center showed that curcumin slowed the progression of multiple
myeloma (blood cancer). With all this evidence (and this is by
no means a complete list) you may be wondering why curcumin
isn’t widely prescribed for the prevention and treatment of
cancer. People in India get curcumin by eating turmeric at
almost every meal. Most Americans are not willing to do this.
That’s why, for most of us, curcumin supplements are the best
option for cancer prevention. Curcumin is safe for just about
everyone. Fat increases bioavailability, taking curcumin with a
meal that includes fat improves absorption.
Curcumin:
hopeful treatment of hemophilic arthropathy via inhibition of
inflammation and angiogenesis Expert Review
of Hematology, November 2019 Curcumin is known for its strong
anti-inflammatory and anti-angiogenic potentials. This agent is
able to inhibit the mentioned inflammatory and angiogenic
factors such as IL-1, IL-6, TNF-α, VEGF, MMPs, and HIF-1α. Also,
as well as anti-angiogenic and anti-inflammatory activity,
curcumin has a strong antioxidant potential and can decrease
oxidative stress.Expert opinion: It seems that curcumin could be
considered as a possible agent for the treatment of HA through
inhibition of inflammation, oxidative stress, and angiogenesis.
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A
meta‐analysis of controlled trials Journal
of Gastroenterology and Hepatology, November 2019 Curcumin,
as an adjuvant treatment of mesalamine, was proved to be
effective and safe in ulcerative colitis. Better efficacy can be
achieved with suitable dose, delivery way, formation, and
intervention time, which needs further study to verify.
How To Treat Joint Problems: This Anti-Inflammatory
Spice May Be The Solution
IBTimes, November 2019 Another benefit that
turmeric is starting to be known for is its ability to reduced
inflammation, particularly in swollen joints. Research shows
that a substance called curcumin, which the turmeric roots are
abundant with, provides a positive impact on the body’s
inflammatory pathways. Curcumin gives turmeric its potent
anti-inflammatory properties. Researchers revealed the many
benefits of turmeric supplements like minimizing inflammation
associated with rheumatoid arthritis and inflammatory bowel
disease or IBS. It has also been proven very effective in the
treatment of abdominal pain for those who are suffering from
IBS. While the study on turmeric has been focused on its ability
to reduce inflammation, researchers say it is also a good source
of strong antioxidants and minerals. Turmeric root extracts have
been observed to protect the cells in the body and counter the
damage caused by free radicals. Turmeric has also been found to
be rich in phosphorus, potassium, and manganese. These minerals
play a vital role in the health of the heart, muscles, and
bones. Muswell recommends adding turmeric to a regular diet to
help increase the intake of minerals and antioxidants that the
body needs.
Curcumin May Improve Adipocyte Health, Adiponectin
Metabolism
Endocrinologyadvisor, November 2019 Curcumin
supplementation moderately increases circulating adiponectin,
which could have beneficial effects on pathways related to
adipocyte health and adiponectin metabolism, according to study
results published in Diabetology & Metabolic Syndrome. The
therapeutic benefits of curcumin, a bioactive yellow-orange
pigment found in turmeric, have been shown in metabolic
diseases. The pooled effect sizes showed that curcumin
supplementation significantly increased adiponectin
concentrations vs placebo.
Best supplements for joints: The exotic spice proven to have
anti-inflammatory properties
Express.co.uk, November 2019 The most
researched beneficial substance found in the turmeric root is
curcumin. Yasmin explained: "Turmeric and curcumin, can impact
inflammatory pathways in the body, giving it it’s powerful
anti-inflammatory properties. Research has shown benefits of
turmeric supplements reducing inflammation with inflammatory
bowel disease (IBD), rheumatoid arthritis and reducing abdominal
pain in IBS sufferers. Although much of the research focuses on
reducing inflammation in these more diagnosable conditions, we
can benefit from anti-inflammatory actions that turmeric has to
offer to counterbalance inflammation coming from a more
westernised style diet."
Curcumin
lessens unpredictable chronic mild stress-induced depression and
memory deficits Pakistan Journal of Pharmaceutical Science, November 2019 Unpredictable chronic mild stress (UCMS) model is the most
established method to study neurobiological mechanisms of
depression. This work was intended to explore the efficacy of
curcumin to revert the UCMS-induced oxidative burden and
associated depression as well as potential of curcumin as an
acetyl cholinesterase (AchE) inhibitor. Findings showed
that curcumin supplementation significantly attenuated the
UCMS-induced depression and anxiety like symptoms, decreased the
load of UCMS propagated oxidative stress by improving
antioxidant enzymes activities. Curcumin also improved the
memory function and exhibited inhibitory effect on AchE
activity. In conclusion it can be suggested that supplementation
of curcumin in daily life can help in combating the
stress-induced depression and ever increasing load of oxidative
stress. Study also highlights the anti-acetylcholinesterase
potential of curcumin which may be responsible for improved
memory function following UCMS.
Curcumin Ameliorates Dermatitis Inflammation Journal, November 2019 Curcumin, extracted from
the roots of Curcuma longa, has been used as an
anti-inflammatory agent since the time of Ayurveda.
Overall, our findings demonstrate that curcumin treatment blunts
the development of AD as well as associated atopic march in
experimental mice.
Curcumin
protects sodium nitrite-induced hepatotoxicity Toxicology Reports, November 2019 Pre-treatment with curcumin
significantly (P < 0.05) prevented these alterations by
adjusting the lipid profile, liver function markers, and
C-reactive proteins and abrogating the elevated markers of
oxidative stress as supported by the liver histology. This
suggests that dietary consumption of curcumin is beneficial
against NaNO2 induced oxidative stress of the liver via its
antioxidant potential.
Fight Diabetes With Curcumin
Only My
Health, November 2019 Curcumin reduced blood sugar and
cholesterol levels by reducing saturated fats found primarily in
dairy products, red meat and helps eliminate trans fats.
Curcumin prevents Liver Fat accumulation, fats accumulated due
to alcohol consumption, reducing hepatocellular inflammation.
Curcumin is known to control white blood cells, which also lead
to inflammation in the body. Curcumin in all its benefits helps
in treating inflammation in the body and further reduce the
complications, as inflammation is a significant reason for
diabetes. Curcumin is also essential in reducing resistance to
insulin. This ingredient also helps insulin get into cells for
preventing diabetes. In a study of 240 people, the only thing
that saved people from diabetes and its symptoms was curcumin.
Around 16% of the 116 people on placebo (inactive treatment) had
Type 2 diabetes in nine months. In simpler terms, curcumin is an
“antioxidant.” It is a known fact that oxygen is an essential
component required to live but also leads to corrosion. Just
like iron rusts in the open air, the reactive oxygen species
also can lead to rusting of blood vessels and other organs. This
study also pointed out towards a connection between curcumin and
a protection layer from oxidation. Curcumin suppresses the
Inflammatory process by inhibiting various cytokines and
interleukins responsible for it.
Curcumin for arthritis Medical Daily,
November 2019 A new study shows that curcumin, a naturally
occurring substance in the spice turmeric, could help improve
the conditions of people with knee osteoarthritis. Researchers
analyzed the effects of curcumin in 139 people. The participants
reported moderately severe symptoms of osteoarthritis and took
treatments with a nonsteroidal anti-inflammatory drug (NSAID).
Researchers divided the patients into groups that took either
diclofenac or curcumin every day for a month. Result showed that
both treatments provided health benefits. Researchers said 94
percent of the group that received curcumin and 97 percent of
those under diclofenac reported up to 50 percent improvement in
their arthritis symptoms. Curcumin causes less side effects.
Some people who took diclofenac required treatment for stomach
problems after the study, while none of the participants taking
curcumin experienced similar unwanted effects.
The
Effects of two Weeks Exhaustive swimming and Curcumin
Supplementation on Liver Damage Department
of Exercise Physiology, November 2019 Curcumin is an active
ingredient in turmeric, which is used as herbal medicine for the
treatment of certain diseases. The reduction of liver damage
markers in this study suggests that exercise and curcumin
consumption may, through protective effects, improve the
negative effects of alcohol on the liver, and prevent alcohol
induced liver disease.
The anti-apoptotic, antioxidant and anti-inflammatory effects of
curcumin on acrylamide-induced neurotoxicity in rats Pharmacology and Toxicology, November 2019 Concurrent
administration of curcumin at the oral doses of 50 and 100 mg/kg
with ACR significantly protected the rats from ACR-induced weigh
loss and motor function deficits, and improved the pathological
alterations in the ACR-intoxicated brains. Curcumin treatment
especially at a high dose enhanced the TERT mRNA expression
level and increased the number of TERT-positive nerve cells in
cortex tissues of ACR intoxicated rats. The levels of MDA, TNF-α
and IL-1β in the cerebral homogenates were reduced, the contents
of GSH as well as the activities of SOD and GSH-Px were
increased by curcumin treatment, compared to ACR control group.
Conclusions: These data suggested the anti-apoptotic,
antioxidant and anti-inflammatory effects of curcumin on
ACR-induced neurotoxicity in rats. And maintaining TERT-related
anti-apoptotic function might be one mechanism underlying the
protective effect of curcumin on ACR-intoxicated brains.
Curcumin and Type 2 Diabetes Mellitus: Prevention and
Treatment
Nutrients, October 2019 Among
these medicinal plants, curcumin is gaining a growing interest
in the scientific community. Curcumin is a bioactive molecule
present in the rhizome of the Curcuma longa plant, also known as
turmeric. Curcumin has different pharmacological and biological
effects that have been described by both in vitro and
in vivo
studies, and include antioxidant, cardio-protective,
anti-inflammatory, anti-microbial, nephro-protective,
anti-neoplastic, hepato-protective, immunomodulatory,
hypoglycaemic and anti-rheumatic effects. In animal models,
curcumin extract delays diabetes development, improves β-cell
functions, prevents β-cell death, and decreases insulin
resistance. The present review focuses on pre-clinical and
clinical trials on curcumin supplementation in T2DM and
discusses the peculiar mechanisms by which curcumin might
ameliorate diabetes management.
Therapeutic Effects of Curcumin—From Traditional
Past to Present and Future Clinical Applications
International Journal of Molecular Sciences, October 2019 The
excellent results of the scientific projects that underlie the
five original papers give reason to hope that curcumin will be
part of novel treatment strategies in the near future—either as
monotherapy or in combination with other drugs or therapeutic
applications.
Curcumin May Help Prevent Or Combat Stomach Cancer,
Study Finds
Waking Times, October 2019 Curcumin — derived from the turmeric plant (Curcuma longa) — has
been used to impart color and flavor to food in many areas of
the world. But long ago, scientists discovered that the bright,
yellow powder can also help prevent and fight stomach cancer.
“We undertook a vast review of the scientific literature on all
nutrients and bioactive compounds with the potential to prevent
or treat stomach cancer and found that curcumin is one of them,”
said Danielle Queiroz Calcagno, first author of the study and a
professor at UFPA.
Curcumin-Induced Autophagy Augments Its Antitumor Effect
against A172 Human Glioblastoma Cells
Biomolecules & Therapeutics, October 2019 Curcumin, from
Curcuma longa, is an effective antitumor agent. Although the
same proteins control both autophagy and cell death, the
molecular connections between them are complicated and autophagy
may promote or inhibit cell death. We investigated whether
curcumin affects autophagy, which regulates curcumin-mediated
tumor cell death in A172 human glioblastoma cells. When A172
cells were incubated with 10 μM curcumin, autophagy increased in
a time-dependent manner. Curcumin-induced cell death was reduced
by co-incubation with the autophagy inhibitors 3-methyladenine
(3-MA), hydroxychloroquine (HCQ), and LY294002. Curcumin-induced
cell death was also inhibited by co-incubation with rapamycin,
an autophagy inducer. When cells were incubated under
serum-deprived medium, LC3-II amount was increased but the basal
level of cell viability was reduced, leading to the inhibition
of curcumin-induced cell death. Cell death was decreased by
inhibiting curcumin-induced autophagy using small interference
RNA (siRNA) of Atg5 or Beclin1. Therefore, curcumin-mediated
tumor cell death is promoted by curcumin-induced autophagy, but
not by an increase in the basal level of autophagy in
rapamycin-treated or serum-deprived conditions. This suggests
that the antitumor effects of curcumin are influenced
differently by curcumin-induced autophagy and the prerequisite
basal level of autophagy in cancer cells.
The Role of Curcumin in the Modulation of Ageing International Journal of Molecular Sciences, October 2019 Curcumin causes the elongation of the lifespan of model
organisms, alleviates ageing symptoms and postpones the
progression of age-related diseases in which cellular senescence
is directly involved. Curcumin is a promising anti-ageing
compound which is easily available and easy to apply in the
diet, as well as being safe and not expensive. Curcumin is a
widely studied nutraceutical, belonging to polyphenols, acquired
from the rhizome of a plant Curcuma longa (turmeric), a member
of the ginger family. The highest achieved serum level of
curcumin was about 1.77 µM, 1 h after administration, during the
oral ingestion of 8 g of curcumin per day, or even 3.6 µM if
such a dose was consumed for 3 months. Data collected by
curcumin researchers showed a large number of beneficial
activities for this compound. They mostly concern its
anti-cancer activity, but, for several years, the amount of data
showing curcumin’s role in the modulation of ageing has been
intensively growing
Curcumin attenuates MSU crystal-induced inflammation
by inhibiting the degradation of IκBα and blocking mitochondrial
damage
Arthritis Research & Therapy,
October 2019 Curcumin administration effectively alleviated
MSU-induced inflammation by suppressing the degradation of IκBα,
the activation NF-κB signaling pathway, the damage of
mitochondria, and the activity of NLRP3 inflammasome. Our
results provide a new strategy in which curcumin therapy may be
helpful in the prevention of acute episodes of gout.
Turmeric Can Support Your Active Lifestyle
Mind Body Green, October 2019 The anti-inflammatory benefits
of turmeric and its compounds called curcuminoids (specifically
curcumin) make the herb work similarly to the anti-inflammatory
painkillers in our medicine cabinets. Studies have shown
promising results in turmeric's ability to help manage muscular
and joint pain after strenuous exercise.
The Health Benefits of Turmeric a Nutritionist Wants
You to Know
Yahoo News, October 2019 Several studies have found that the key protective compound in
turmeric, called curcumin, reduces inflammation, and its effects
are on par with some anti-inflammatory medications. Curcumin
also acts as an antioxidant, to counter damaging compounds
called free radicals, and fight what’s known as oxidative
stress. In a nutshell, oxidative stress occurs when there is an
imbalance between the production of cell-damaging free radicals
and the body's ability to counter their harmful effects. Because
of curcumin's anti-inflammatory and antioxidant benefits,
turmeric has health benefits for skin, preventing or helping to
repair visible signs of aging. Curcumin has also been shown to
increase levels of neurotrophic factor (BDNF) in the brain.
That’s crucial, because BDNF acts as a type of growth hormone
that protects the brain from age-related decline or damage. Low
BDNF levels are tied to depression, as well as Alzheimer’s.
Turmeric – the Golden Spice and wonder drug
Deccan Herald, October 2019 Another research finding says:
The results obtained from the present review revealed that
curcumin can be effective in various types of oxidative
associated liver disorders. This potentiality attributes to
curcumin effects on hepatotoxicity, non-alcoholic
steatohepatitis, alcoholic liver disease, liver fibrosis and
cirrhosis as well as hepatic injury. Experimental evidence
indicates that curcumin exhibits its preventive and curative
effect against oxidative associated liver diseases.
Pre-administration of curcumin prevents
hyperhomocysteinemia in ethanol-induced gastric ulcer
World Journal of Pharmacy and Pharmaceutical Sciences, October
2019 Curcumin is a prototype natural product that has been
widely recognized as an antioxidant and anti-inflammatory agent.
In this study, we aimed to evaluate the potentialrole of
curcumin supplementation in attenuating the aggressive effect of
alcohol in experimental induced gastric ulcer. Whereas,
pre-treatment of curcumin prevented the hyperhomocysteinemia and
the elevation of TNF-α resultingin a depletion of gastric ulcer.
We concluded that, curcumin is considered a promising supplement
in attenuating gastric ulcer through its important role in
depletion of oxidative stress and inflammation.
Effects
of Curcumin and Silymarin on the bacterium Shigella dysenteriae
and Campylobacter Journal of
Gastrointestinal Cancer, September 2019 In this study,
curcumin and silymarin could inhibit the growth of S.
dysenteriae and C. jejuni and 100 μg/ml sub-MIC levels exhibited
the suppression of housekeeping genes. Combating pathogenic
bacteria by compounds alternative to antibiotics in the era of
antibiotic resistance is a proper strategy, though more studies
using combinations of them are needed.
High blood pressure: Could this popular spice lower your bp
reading? Express,
September 2019 One study suggests the super spice may also
help to lower a blood pressure spike. According to Dr Sinatra,
turmeric’s potential blood pressure reducing benefits come from
its active ingredient, as he explained: “Its [turmeric] yellow
colour comes from curcumin — a powerful antioxidant and
anti-inflammatory compound that’s been found to reduce blood
pressure by lowering the excess platelet aggregation that occurs
in sticky, clot-forming blood." Turmeric could help to control a
soaring blood pressure High blood pressure: Turmeric could help
to control a soaring blood pressure (Image: Getty Images )
Researchers in a study, published in the journal Scientific
Reports, concluded that curcumin works much the same way as
ginger as it inhibits the transport of calcium, which acts as a
chemical messenger that tells muscle cells to contract, thereby
dilating the arteries. Therefore, taking turmeric for high blood
pressure, due to its active ingredient curcumin, could be an
effective remedy.
Anti-infective Properties of the Golden Spice
Curcumin Frontiers in Microbiology,
September 2019 The search for novel anti-infectives is one of
the most important challenges in natural product research, as
diseases caused by bacteria, viruses, and fungi are influencing
the human society all over the world. Natural compounds are a
continuing source of novel anti-infectives. Accordingly,
curcumin, has been used for centuries in Asian traditional
medicine to treat various disorders. Numerous studies have shown
that curcumin possesses a wide spectrum of biological and
pharmacological properties, acting, for example, as
anti-inflammatory, anti-angiogenic and anti-neoplastic, while no
toxicity is associated with the compound. Recently, curcumin’s
antiviral and antibacterial activity was investigated, and it
was shown to act against various important human pathogens like
the influenza virus, hepatitis C virus, HIV and strains of
Staphylococcus, Streptococcus, and Pseudomonas.
Turmeric For Rheumatoid Arthritis
Medicaldaily.com September 2019 According to a
review article published in the US National Library of Medicine,
turmeric is rich in curcumin that has an antioxidant effect,
lowers blood sugar, is anti-inflammatory and affords anticancer
benefits. Since rheumatoid arthritis is an autoimmune disease
that mistakenly attacks healthy joint tissue, patients
experience inflammation that leads to bone and joint damage. The
anti-inflammatory properties of turmeric could alleviate its
symptoms. Curcumin In a 2016 systematic review, researchers
measured the effectiveness of turmeric and curcumin extracts on
arthritis patients. Those who took 1,000 milligrams of curcumin
daily for eight to 12 weeks reduced their pain sensations and
inflammation which are common symptoms of osteoarthritis.
Researchers found that curcumin extracts are effective in
treating these symptoms by recommending patients to take
nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen
and diclofenac. They, however, noted that there is a need for
further research to confirm their findings. Nevertheless, they
recommended that arthritis patients may use curcumin as a
dietary supplement while undergoing conventional therapy. A
subsequent study looked into the effects of curcumin on rats
with rheumatoid arthritis. Researchers determined that the
component reduced inflammation and redness among the lab rats by
blocking an intercellular signaling process called mTOR pathway.
Curcumin as a permeability enhancer enhanced the
antihyperlipidemic activity of green tea extract BMC Complementary and Alternative Medicinevolume 19, September
2019 Curcumin, obtained from Curcuma longa, is used as
bio-enhancer for anti-microbial agents and anti-cancer drugs. It
shows strong antioxidant, anti-inflammatory, anti-mutagenic and
anti-carcinogenic properties. Curcumin can recover
chemically-induced oxidative stress as well as increase
xenobiotic detoxifying enzymes’ activities in both the liver and
kidneys and suppress lipid peroxidation. Curcumin has low
solubility and low permeability from intestine due to
P-glycoprotein pump (P-gp). Curcumin acts by two
mechanisms:suppression of drug metabolising enzymes in liver and
inducing changes in drug transporter P-gp. Curcumin is initially
absorbed from intestine, but is effluxed again inside intestine
by P-gp. Curcumin and EGCG both are effluxed by P-gp; hence
curcumin can play a pivotal role of inhibiting P-gp, thereby
enhancing permeation of EGCG by inhibiting its efflux.
Understanding use of turmeric in herbal medicine Guardian, September 2019 Curcumin, the
major active ingredient in Turmeric has a wide range of
medicinal activities and it is composed of phytochemicals,
mineral/vitamins and dietary fiber. Minerals in curcumin are
magnesium, potassium, sodium, iron, manganese, calcium,
phosphorus and selenium. The following vitamins are included in
Turmeric, vitamins C, E, K, B6 and folate. Turmeric is a very
good source of dietary fiber and fatty acids are w-fatty acid
and alpha-linolenic acid. Curcumin possesses anticancer
properties along with anti-inflammatory, anti-Alzheimer’s and
anti-tumour potentials. It also has hepatoprotective,
neuroprotective, cardioprotective, anti-rheumatic,
anti-diabetic, hypoglycemic and analgesic activities. The
essential oils in curcumin are ar-turmerone, alpha-turmerone and
beta-turmerone and they are biologically active constituents.
These essential oils are endowed with anti-cancer,
anti-inflammatory, antimicrobial and antioxidative potentials.
The curcuminoids and the volatile essential oils are responsible
for the health benefits of turmeric.
7 Benefits of Turmeric News18.com September
2019 1.Acts against Inflammation: Inflammation can become a
major problem when it becomes chronic, inappropriately attacks
body’s own tissues. Curcumin, a compound found in turmeric, is a
naturally and strongly anti-inflammatory. It matches the
effectiveness of some anti-inflammatory drugs, without the side
effects. 2.Increases Antioxidant Capacity: Antioxidants are
beneficial for the body as they protect it from free radicals,
which tend to react with important organic substances, such as
fatty acids, proteins or DNA. Curcumin has powerful antioxidant
effects, which neutralizes free radicals on its own and
stimulates body’s own antioxidant enzymes. 3.Lowers the risk of
heart disease: Curcumin can help reverse many steps in the heart
disease process, as it improves the function of the endothelium,
which is the lining of your blood vessels. 4.Helps in Skin Care:
Turmeric keeps the skin healthy in many ways, such as keeping
pimples at bay by inhibiting the growth of pimple, clearing acne
scars and making your skin flawless, healing of a cut and
soothing skin irritation, and fighting signs of ageing like
wrinkles and pigmentation by curbing the growth of free
radicals. 5.Helps in Weight Loss: Turmeric helps in accelerating
the metabolism rate and letting the body burn a significant
number of calories, leading to weight loss. It is also useful in
reducing fat mass and detoxification of the liver, which are
essential contributors when it comes to diet-induced weight loss
efforts. 6.Improves Brain Function: Turmeric is known to boost
cognitive abilities, increase concentration, and boost memory
retention. It also protects the neural pathways from long-term
oxidative stress and the build-up of plaque. 7.Treats
Depression: Curcumin has a similar effect like Prozac on
patients suffering from depression, mood swings, anxiety, and
stress, making it a powerful alternative to pharmaceutical
routes, which often have dangerous or addictive side effects.
Curcumin Inhibits Proliferation and Migration of A549 Lung
Cancer Cells Natural Product
Communications, August 2019 Curcumin is a major component of
turmeric with promising tumor-suppressive activity; however, its
underlying molecular mechanisms need to be investigated further.
Collectively, our data suggested that curcumin induces autophagy
via activating the ERK1/2 pathway and the autophagy is important
for the inhibiting effect of curcumin in lung adenocarcinoma
cells.
Curcumin plays a dual role: in adjuvant therapy and reversal of
drug resistance in acute myelogenous leukemia
journalcmpr, August 2019 The results obtained highlight
the potential of curcumin in enhancing the efficacy of cyt and
overcoming drug resistance in AML. Thus, this study shows that
curcumin may effectively be used as an adjuvant therapy in AML.
Benefits
of curcumin in brain disorders Biofactors.
2019 August, 2019 Curcumin is widely consumed in Asia either
as turmeric directly or as one of the culinary ingredients in
food recipes. The benefits of curcumin in different organ
systems have been reported extensively in several neurological
diseases and cancer. Curcumin has got its global recognition
because of its strong antioxidant, anti-inflammatory,
anti-cancer, and antimicrobial activities. Additionally, it is
used in diabetes and arthritis as well as in hepatic, renal, and
cardiovascular diseases. Recently, there is growing attention on
usage of curcumin to prevent or delay the onset of
neurodegenerative diseases. This review summarizes available
data from several recent studies on curcumin in various
neurological diseases such as Alzheimer's disease, Parkinson's
disease, Multiple Sclerosis, Huntington's disease, Prions
disease, stroke, Down's syndrome, autism, Amyotrophic lateral
sclerosis, anxiety, depression, and aging. This review also
summarizes the ongoing clinical trials on curcumin for different
neurodegenerative diseases and patent details of
curcuma/curcumin in India.
Cardiac Rehabilitation-Curcumin, Cardiovascular Disease, Heart
Failure peoplebeatingcancer.com August 2019 Curcumin supplementation can: attenuate adriamycin-induced
cardiotoxicity reduce my cholesterol reduce my risk of DVT and
stroke helps dissolve my post-thrombotic syndrome All is one
inexpensive, non-toxic nutritional supplement. If it sounds as
though curcumin is a wonder drug, it is. Curcumin also is
cytotoxic (kills) to my cancer, multiple myeloma.
“Curcumin (diferuloylmethane) is a polyphenol responsible for
the yellow color of the curry spice turmeric. It has been used
in a variety of diseases in traditional medicine. Modern
scientific research has demonstrated its anti-inflammatory,
anti-oxidant, anti-carcinogenic, anti-thrombotic, and
cardiovascular protective effects. In this review, we focused
mainly on the effects of curcumin on the cardiovascular system.
The antioxidant effects of curcumin have been shown to attenuate
adriamycin-induced cardiotoxicity and may prevent diabetic
cardiovascular complications. The anti-thrombotic,
anti-proliferative, and anti-inflammatory effects of curcumin
and the effect of curcumin in decreasing the serum cholesterol
level may protect against the pathological changes occurring
with atherosclerosis. The p300-HAT inhibitory effects of
curcumin have been demonstrated to ameliorate the development of
cardiac hypertrophy and heart failure in animal models. The
inflammatory effects of curcumin may have the possibility of
preventing atrial arrhythmias and the possible effect of
curcumin for correcting the Ca(2+) homeostasis may play a role
in the prevention of some ventricular arrhythmias. The
preclinical studies from animal to clinical data in human are
discussed.” Efficacy and safety of turmeric and curcumin in
lowering blood lipid levels in patients with cardiovascular risk
factors: a meta-analysis of randomized controlled trials
“Conclusions- Turmeric and curcumin may protect patients at risk
of CVD through improving serum lipid levels. Curcumin may be
used as a well-tolerated dietary adjunct to conventional drugs.
Curcumin induced oxidative stress attenuation by
N-acetylcysteine co-treatment Molecular
Medicine, August 2019 Curcumin has been shown to have a broad
range of antioxidant, antibacterial, antifungal, antiviral,
anti-inflammatory, anti-proliferative, and pro-apoptotic
properties (Aggarwal & Sung, 2009). Curcumin has also been
reported to have anti-fibrotic capabilities in studies of wound
healing, liver fibrosis and lung fibrosis models (Lin et al.,
2009; Yao et al., 2012; Zhang et al., 2011; Smith et al., 2010;
Chen & Zheng, 2008). At the molecular level, curcumin has been
reported to play an anti-fibrotic role by modulating
transcription factors such as transforming growth factor beta
(Chen et al., 2013; Liu et al., 2016), platelet-derived growth
factor, fibroblast growth factor and tumor necrosis factor alpha
(Shishodia, 2013; Hua et al., 2013; Das & Vinayak, 2014), all of
which are implicated in the pathogenesis of IPF. Due to these
antifibrotic properties of curcumin, a number of investigators
have hypothesized that this compound could serve as a possible
therapeutic for IPF (Smith et al., 2010; Liu et al., 2016; Xu et
al., 2007). These studies focus on the antifibrotic effects of
curcumin and, like many other in-vitro studies, report a
reduction in profibrotic responses when pulmonary fibroblasts
are treated in isolation.
Foods to
Feed Both Body and Mind Entrepeneur.com
August 2019 Turmeric is the spice that gives curry its yellow
color. Curcumin is the main active ingredient in turmeric. This
spice is found in foods from India, Indonesia and Thailand, and
has been shown to have any great health benefits. Curcumin is
known to boost brain function and lower the risk of brain
disease because it increases the levels of an important growth
hormone in the brain known as the brain-derived neurotrophic
factor. Many of the studies researching the benefits of turmeric
use extracts that contain mostly curcumin, in quantities
exceeding one gram per day. In order to get the full effects,
you may consider taking a supplement that contains curcumin.
Yellow curry spice turmeric could prevent stomach
cancer
The
London Economic, July 2019
The active ingredient
curcumin suppress cancer cells and induces apoptosis, or “cell
death”, researchers discovered. The review found that curcumin,
derived from the roots of the turmeric plant, could also work
against gastric tumors. Professor Danielle Queiroz Calcagno said
that researchers undertook a vast scientific review. She said:
“We looked at all nutrients and bioactive compounds with the
potential to prevent or treat stomach cancer and found that
curcumin is one of them. “These compounds can favour the
activation or repression of genes involved in the development of
stomach cancer by promoting or inhibiting histone acetylation.”
Curcumin influences histones by inhibiting acetyltransferases to
suppress cancer cells and induce apoptosis, or cell death.
Cellular and molecular mechanisms of curcumin in prevention and
treatment of disease Critical Reviews in
Food Science and Nutrition, July 2019 Curcumin is known to
reverse vari- ous ailments of the nervous system, cardiovascular
system, digestive system, respiratory system, endocrine system,
renal system, etc. According to recent and well-designed
clinical study, consumption of curcumin exerts beneficial effect
against metabolic syndrome, skin diseases, cancer, gut
inflammation, depression, arthritis, fatty liver disease and
premenstrual syndrome. Furthermore, the anti-inflammatory and
antioxidant potential of curcumin supplementation for its
beneficial effect against arthritis and metabolic syndrome has
been reviewed. Curcumin has been reported to bind directly to
signaling molecules, such as carrier proteins, DNA
methyltransferases 1, xanthine oxidase, human immunodeficiency
virus (HIV)- 1 integrase, filamenting temperature-sensitive
mutant Z (FtsZ) protofilaments, glyoxalase I, proteasome,
histone deacetylase, histone acetyltransferase, cell survival
proteins, HIV-1 protease, protein reductases, protein kinases,
inflam- matory molecules and metal ions (Gupta et al. 2011).
Curcumin treatment modulated b-secretase 1 (BACE-1),
acetylcholinesterase (AChE) activity, chemokines, toll-like
receptor (TLR), cyclooxygenase (COX), brain-derived neuro-
trophic factor (BDNF), tropomyosin receptor kinase B (TrkB),
c-Jun N-terminal kinase (JNK), insulin receptor substrate-1
(IRS-1), inhibitor of NF-kB (IkB), glutathione-S- transferase,
endothelial haeme oxygenase-1 (HO-1), extracel- lular receptor
kinases (ERKs), low density lipoprotein-recep- tor (LDL-R),
activator protein 1 (AP-1), peroxisome proliferator-activated
receptor-gamma (PPAR-c), liver X receptor-b(LXR-b), retinoid X
receptor (RXR)-a, c-Jun and tumor necrosis factor alpha (TNF-a)
(Ray and Lahiri 2009; Hamaguchi, Ono, and Yamada 2010; Farooqui
2013; Tian et al. 2013). Curcumin treatment is reported to exert
its beneficial effect through various kinases such as focal
adhe- sion kinase (FAK), acid activated protein kinase C (AAPK),
epidermal growth factor receptor-kinase (EGFRK), protein
tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK),
protein kinase A (PKA), protein kinase B (PKB), ERK,
p21-activated kinase (PAK), janus kinase (JAK), inter- leukin
(IL)-1, Rak and pp60C-TK. Curcumin also demon- strates
significant action via growth factors like fibroblast growth
factor (FGF), hepatocyte growth factor (HGF), epi- dermal growth
factor (EGF), platelet-derived growth factor (PDGF),
transforming growth factor-b1 (TGF-b1) and vas- cular
endothelial growth factor (VEGF). Cytokines such as IL-1b, IL-1,
IL-6, IL-8, IL-12, TNF-aand monocyte chemo- attractant protein-1
(MCP-1), and several transcription fac- tors like nuclear factor
kappa B (NF-kB), Ap-1, Notch-1, CREB-binding protein (CREB-BP),
early growth response-1 (Egr-1), Wilms’tumor gene 1 (WT-1),
b-catenin, hypoxia- inducible factor-1 (HIF-1), nuclear factor
2-related factor (Nrf-2) and estrogen response element (ERE) are
also the molecular targets of curcumin (Kunnumakkara et al.
2017; Derosa et al. 2016; Sahebkar et al. 2016). Curcumin exerts
beneficial effects through various receptor such as integrin
receptor (IR), Fas receptor (Fas-R), EGFR, HER-2, IL-8R, C- X-C
chemokine receptor type 4 (CXCR4), estrogen receptor- alpha
(ER-a), endothelial cell protein C receptor, histamine
(2)-receptor (H2R), LDL-R, androgen receptor (AR) and DR-5.
Anti-infective Properties of the Golden Spice
Curcumin Frontiers in Microbiology, July
2019 The search for novel anti-infectives is one of the most
important challenges in natural product research, as diseases
caused by bacteria, viruses, and fungi are influencing the human
society all over the world. Natural compounds are a continuing
source of novel anti-infectives. Accordingly, curcumin, has been
used for centuries in Asian traditional medicine to treat
various disorders. Numerous studies have shown that curcumin
possesses a wide spectrum of biological and pharmacological
properties, acting, for example, as anti-inflammatory,
anti-angiogenic and anti-neoplastic, while no toxicity is
associated with the compound. Recently, curcumin’s antiviral and
antibacterial activity was investigated, and it was shown to act
against various important human pathogens like the influenza
virus, hepatitis C virus, HIV and strains of Staphylococcus,
Streptococcus, and Pseudomonas. Despite the potency, curcumin
has not yet been approved as a therapeutic antiviral agent. This
review summarizes the current knowledge and future perspectives
of the antiviral, antibacterial, and antifungal effects of
curcumin.
Wikipedia Fails Again: The Case of Misinformation
about Curcumin
PRN.fm
July 2019 Just in the US official scientific library
of medicine with almost 12,000 studies, the evidence
overwhelmingly supports curcumin’s medicinal and functional
benefits. That does not include the thousands of studies in
medical journals in other cournties where turmeric has been used
as a nutritional enhancer for millennia. Wikipedia’s absurd
statement that “although long used in Ayurvedic medicine… no
high-quality clinical evidence exists for use of turmeric or its
constituent, curcumin, as a therapy,” requires little comment
for the hundreds of pages simply listing research about the
herb’s medicinal value. Just a few of the research study titles
include: Curcumin administration reduces depressive symptoms in
patients with major depression (Phytotherapy Research, 2015)
Curcumin or combined curcuminoids are effective in lowering the
fasting blood glucose concentrations of individuals with
dysglycemia (Pharmacological Research, 2017) Curcumin appears to
enhance clearance of amyloid-beta in Alzheimer’s disease patient
(Journal of Alzheimers Disease, 2006) Meta-analysis of
randomized controlled trials of 4 weeks or longer suggest that
curcumin may afford some protection against oxidative stress
(Nutrition Research, 2018) A curcumin extract is appropriate for
the care of patients with joint problems and may also contribute
to the regeneration of cartilage (Open Rheumatological Journal,
2014) A daily dose of 3.6 g curcumin achieves pharmacologically
efficacious levels in the colorectum with negligible
distribution of curcumin outside the gut (Cancer Epidemiological
Research, 2005) A topical preparation of curcumin successfully
decreased the markers of lactational mastitis such as pain,
breast tension and erythema within 72 hours of administration
(Oman Medical Journal, 2014) Curcumin alleviates ethanol-induced
oxidative damage in liver cells (Journal of Ethnopharmacology,
2010) We can trust the accumulation of nearly 12,000 studies in
the official peer reviewed data library. We can count upon the
countless other studies in the world’s other databases. We can
trust the numerous doctors throughout history in culture’s
worldwide with proven clinical experience. Or we can trust a
tiny group of expert wannabes, Skeptics, who are anonymous and
have no noticeable education or experience in nutritional
biochemistry and preventative medicine. And this group
dominating Wikipedia’s health pages are ideologically and
frequently politically aligned with the pharmaceutical industry.
This is a long sorted history of Big Pharma relying upon faux
scientists, public relations firms and astroturf groups for hire
to promulgate its ideology.
Chemopreventive efficacy of oral curcumin: a prodrug
hypothesis Federation of American Societies
for Experimental Biology, July 2019 Oral consumption of
curcumin, a natural polyphenol, is associated with reduced
incidence of cancer. Yet, a significant amount of the orally
dosed compound is eliminated in the feces, and a major fraction
of the absorbed compound is metabolized to inactive
glucuronides, resulting in poor bioavailability (<1%). It is not
known how oral curcumin exhibits chemopreventive activity. We
propose curcumin glucuronide is an inflammation-responsive
natural prodrug that is converted back to curcumin on demand at
the site of action. Our studies show elevated levels of
β-glucuronidase, an enzyme that hydrolyzes the glycosidic bond
of glucuronides to generate the parent compound, in human breast
cancer. Oral administration of curcumin in mouse tumor models
generated significant tumor levels of the polyphenol.
Intravenous administration of the glucuronide resulted in the
formation of curcumin in the tumor tissue. Chronic daily oral
curcumin dosing led to tumor accumulation of curcumin and
inhibition of tumor growth in tumor models with high
β-glucuronidase activity. Overall, the study presented here
provides preliminary evidence for a novel mechanism of action
for orally administered curcumin.
How Turmeric Can Help in Weight Loss Latestly.com, July 2019 Curcumin is an antioxidant and
anti-inflammatory ingredient found in turmeric with weight loss
benefits. According to a study conducted by researchers at Tufts
University in 2009, curcumin slowed weight gain in mice by
preventing new fat tissues from forming. When mice were fed with
turmeric it prevented them from developing new blood vessels and
less fat tissue. The study also revealed that mice who were fed
with this anti-oxidant agent had less fat in their livers and
lower cholesterol levels than mice who weren’t. As per the
latest study conducted by The Journal of Nutritional
Biochemistry, Korean scientist identified that curcumin induces
browning in white adipose tissue. There are two types of adipose
tissues -- brown and white. White adipose tissue stores energy
and increases with weight gain. On the other hand, brown adipose
tissue produces heat by burning fat. Curcumin in turmeric
stimulates the production of mitochondria which converts sugars,
proteins and fat into energy.
Effects of Turmeric on Your Body
Galpost.com, July 2019
Scientists have discovered that curcumin inhibits the production
of fat cells and improves the metabolism of carbohydrates, which
reduces fat after eating bread, pasta, potatoes and other
carbohydrates.
Why All Diabetics Should Know About Turmeric
I Thrive Series, July 2019
A recent literature review published in the International
Journal of Endocrinology and Metabolism titled,
“Anti-Hyperglycemic Effect and Insulin Sensitizing Effects of
Turmeric and Its Principle Constituent Curcumin,” adds promising
new support to the notion that the ancient Indian spice turmeric
may provide an ideal drug alternative to treating and perhaps
even preventing type 2 diabetes, which has become of the world’s
most prevalent diagnoses. The study reviewed research published
between 1998 to 2013 that indicates the active polyphenol in
turmeric known as curcumin may provide an ideal intervention for
type 2 diabetes, capable of mitigating characteristic
pathophysiological hallmarks of the disease such as elevated
blood sugar (hyperglycemia) and insulin resistance. Nineteen of
the studies reviewed were cell (in vitro) and animal (in vivo),
all which showed beneficial effects. Five of the studies were
human clinical trials using turmeric or curcumin, three of which
were performed in those with either diabetes or prediabetes.
Amazingly, the animal and cell research literature review
concluded that curcumin could improve the type 2 diabetic state
through 10 distinctly different mechanisms, such as: Reduction
in liver glucose production Reduction in liver glycogen
production Stimulation of increased glucose uptake (by
increasing GLUT4, GLUT2 and GLUT3 gene expressions) Increasing
the activation of AMP kinase Promoting PPAR γ ligand- binding
activity Suppressing hyperglycemia-induced inflammatory state
Stimulating insulin secretion from pancreatic tissues
Improvement in pancreatic cell function, Increasing
phosphorylation of AKT Increasing insulin receptor β and
reduction of insulin resistance The human clinical research
conducted on diabetic and pre-diabetic patients revealed that
curcumin had the following beneficial effects: Glucose lowering
effect Improved beta cell function Improved fatty acid oxidation
and utilization
Effects of Notch Signaling Pathway in Cervical
Cancer by Curcumin Journal of Cancer, July
2019 Curcumin, as a high effectand low toxicity anti-cancer
drug and photosensitiser, has synergisticand
complementaryeffects with photodynamic therapy. We found both
DAPT and curcumin-PDT can inhibit the proliferation and induce
apoptosis of cervical cancer cell.
Can Turmeric Help Prevent or Treat Type 2 Diabetes? Everydayhealth.com, July 2019 The likely driver of turmeric’s
potential health benefits is curcumin, the primary active
chemical in this yellow-orange spice. “Curcumin is what has
mostly been studied because of its important signaling pathways.
It acts mostly in two areas: It's an antioxidant and an
anti-inflammatory,” says Marina Chaparro, RDN, MPH, a certified
diabetes educator and a national spokesperson for the Academy of
Nutrition and Dietetics. a study published in April 2015 in the
Indian Journal of Clinical Biochemistry found that human
participants who supplemented their Glucophage (metformin) — a
diabetes medication that helps lower blood sugar — with turmeric
did lower their blood sugar, inflammation, and levels of
oxidative stress. In another human study — this one a randomized
controlled trial that was published in 2012 in Diabetes Care — a
supplement of 250 milligrams of curcumin daily was associated
with a delay in participants progressing from prediabetes to
type 2 diabetes. Researchers studied 240 people for nine months
and reported that at the end of the study, 16.4 percent of
people in the placebo group developed type 2 diabetes, versus 0
percent in the curcumin-supplemented group. Participants didn’t
report any side effects except for mild stomachaches.
Furthermore, in the Diabetes Care study, curcumin notably
appeared to help improve the function of beta cells, which
research shows help produce the hormone insulin. Insulin is
responsible for ferrying glucose to cells, but in type 2
diabetes, cells become insensitive to glucose, leading to high
blood sugar. As the pancreas cranks out more insulin to try to
lower blood sugar levels, blood sugar remains elevated because
of insulin resistance — until it wanes in producing insulin
because of beta cell dysfunction.
Pharmacognostic Studies on Curcuma Longa International Journal of Pharmacognosy and Chinese Medicine,
July 2019 The turmeric (Curcuma longa) plant, a perennial
herb belonging to the ginger family, is cultivated extensively
in south and southeast tropical Asia. The rhizome of this plant
is also referred to as the “root” and is the most useful part of
the plant for culinary and medicinal purposes. The most active
component of turmeric is curcumin, which makes up 2 to 5% of the
spice. The characteristic yellow color of turmeric is due to the
curcuminoids. Curcumin is an orange–yellow crystalline powder
practically insoluble in water. Turmeric is used as a dietary
spice, coloring agent in foods and textiles, and a treatment for
a wide variety of ailments. It is widely used in traditional
Indian medicine to cure biliary disorders, anorexia, cough,
diabetic wounds, hepatic disorders, rheumatism, and sinusitis.
Turmeric paste in slaked lime is a popular home remedy for the
treatment of inflammation and wounds. For centuries, curcumin
has been consumed as a dietary spice at doses up to 100 mg/d.
Extensive investigation over the last five decades has indicated
that curcumin reduces blood cholesterol, prevents LDL oxidation,
inhibits platelet aggregation, suppresses thrombosis and
myocardial infarction (MI), suppresses symptoms associated with
type II diabetes, rheumatoid arthritis, multiple sclerosis (MS),
and Alzheimer’s disease, inhibits human immunodeficiency virus
(HIV) replication, enhances wound healing, protects from liver
injury, increases bile secretion, protects from cataract
formation, and protects from pulmonary toxicity and fibrosis, is
an anti-leishmaniasis and an antiatherosclerotic. Additionally,
there is extensive literature that suggests that curcumin has
potential in the prevention and treatment of a variety of other
diseases.
Turmeric and its medicinal properties
Guardian, July 2019
Curcumin is the yellow pigment in Turmeric and the most
medicinally active compound therein. Curry, the very common
spice that we add to our stews and soups is from curcumin. There
are about100 chemical compounds in turmeric. These chemical
compounds confer certain uniqueness to this herb and give it the
ability to treat several disease conditions. The curcumin in
turmeric is made up of polyphenols, which are organic chemicals
that possess anti-inflammatory properties. Polyphenols are also
present in some other types of foods and beverages also.
Examples of these are epigallocatechin gallate (ECGC) found in
green tee, resveratrol in red grapes and red wine and capsaicin
in chili peppers. Curcumin is part of a group of chemical
compounds known as curcuminoids and others in the group are
demethoxycurcumin and bisdemethoxycurcumin. Curcumin is what is
responsible for the health benefits of turmeric.
Tips to increase brain power
Newstracklive.com,
July 2019 Turmeric: The curcumin in turmeric is
antidepressant and helps improves memory. It has been found that
people suffering from Alzheimer’s have small proteins called
amyloid-beta which causes damage to the brain. It is neurotoxic
and forms neurofibrillary tangles in the brain that leads to
Alzheimer’s. Curcumin works to protect the brain from this
damage.
The Wonders of Turmeric: Why It’s Good For You
Society19, July 2019
One
of the reasons why turmeric is good for you because it is
anti-inflammatory. Turmeric contains curcumin, a chemical that
not only is responsible for the bright yellow colour, but is
said to contain anti-inflammatory properties. In some cases,
curcumin is so potent that it can be as effective as
anti-inflammatory drugs. One study actually discovered that
curcumin was more effective in fighting against inflammation
than aspirin and ibuprofen. Another reason why this spice is
good for you is that it can prevent cancer. As mentioned above,
curcumin has anti-inflammatory properties, but that is not the
only thing it can do. Curcumin is also beneficial in treating
cancer, as it affects cancer growth and development. One study
has discovered that curcumin can inhibit tumor initiation and
promotion, as well as inhibit metastasis and cell proliferation.
Considering that turmeric contains curcumin, it is no surprise
that the yellow spice is beneficial to the joints and can
prevent them from getting swollen and inflamed. It has been
discovered that curcumin is able to help with arthritis,
including rheumatoid arthritis, to the point that it is
considered to be more effective than anti-inflammatory drugs.
Turmeric, ‘The Golden Spice’ is 1 of the Most
Beneficial Spices in World
Live Trading News, July 2019
Turmeric, known as ‘The
Golden Spice of Life’ is of the most beneficial spices in the
culinary world. It is due to the astounding amounts of curcumin
it contains, its principal bioactive component. According to a Y
2017 study published in the journal Foods, curcumin contains
antioxidant and anti-inflammatory properties since ancient times
known to assist in alleviating arthritis, metabolic syndrome and
hyperlipidemia. A 2016 study from Drug Design, Development and
Therapy showed that curcuminoids and curcumin extracts helped
alleviate pain and improved both physical function and quality
of life.7 •May help improve behavioral symptoms of Alzheimer’s
and dementia — A Y 2012 study found that the daily
administration of turmeric to Alzheimer’s disease and dementia
patients helped reduce irritability, agitation, anxiety, apathy
and other Alzheimer’s disease symptoms. •Provides an immune
system boost — According to a Y 2018 study from the Journal of
Cellular Physiology, curcumin affects numerous immune cells,
including natural killer cells and B lymphocytes, supporting the
body against immune system-related diseases.
Life-saving compound can DESTROY stomach cancer
Healthier Talk, July 2019
Curcumin appears to attack the protein that keeps the DNA of
each cancer cell in order. So essentially it causes the DNA to
unravel – forcing those cells to die. While this animal study
isn’t quite on the same level as a controlled clinical trial,
the evidence has been building for years. And the signs all
point to curcumin being a potent weapon in the war against
stomach cancer. Curcumin could starve cancer cells In 2017, a
study even showed WHY curcumin is so effective: The acids in
your stomach can act like fertilizer for these cancers. The
tumors suck it up and use it to GROW. Curcumin can help tame
those acids, not necessarily by reducing the levels but changing
how they’re secreted so less gets to the tumor. As a result, the
cancer cells in the study weren’t able to get that fertilizer…
and DIED because of it. More study is needed, of course. But
that makes curcumin one of the most promising natural therapies
yet in the fight against stomach cancer. That could mean that if
you DON’T have cancer, curcumin supplements can prevent it from
forming and taking hold. And if you DO have cancer, curcumin
could help fight it off.
Natural Remedies Proven to Help Control Pain Care2, July 2019 Scientists believe most of turmeric’s health
benefits come from its high curcumin content. One of curcumin’s
proven abilities is helping to combat pain, such as muscle pain
and post-surgical pain. In an Indian study, curcumin was shown
to be more effective for relieving rheumatoid arthritis pain
than standard drug treatment. You can buy prepared turmeric and
curcumin supplements. Fresh or dried turmeric is also easy to
incorporate into many different dishes and include in your daily
diet. The curcumin in turmeric can be difficult to digest, but
research has shown that curcumin is much more easily absorbed
when it’s eaten with black pepper and fats. So, add a dash of
pepper and a dab of olive, coconut or other healthy oil in your
meals to get the most pain-fighting action out of your turmeric.
Modulatory effects of curcumin on heat shock
proteins in cancer: A promising therapeutic approach Biofactors, July 2019 Curcumin (diferuloylmethane) is a
potent anti‐inflammatory, antioxidant, antimicrobial, and
antitumor agent. Curcumin has been shown to regulate different
members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90
in cancer. Here, we present extent findings suggesting that
curcumin may act as a potential therapeutic agent for the
treatment of cancer through its regulation of HSPs.
Curcumin: a therapeutic strategy in cancers by
inhibiting the canonical WNT/β-catenin pathway Journal of Experimental and Clinical Cancer Research, July 2019 Numerous studies have presented that curcumin could have a
positive effect in the prevention of cancer and then in tumor
therapy. Several hypotheses have highlighted that curcumin could
decreases tumor growth and invasion by acting on both chronic
inflammation and oxidative stress. Curcumin (1,7-bis
(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a
natural product which occurs polyphenolic phytochemical
properties from the rhizome of the Curcuma longa. Curcumin has
been discovered in 1815 by Vogel and Pelletier. Its
yellow-colored hydrophobic component is traditionally used in
Asian countries for its several properties against
pathophysiological states including anticancer . Several targets
of curcumin have been shown to have chemotherapeutical
properties. Curcumin use may have a major role in the control of
inflammation, angiogenesis, metastasis and proliferation .
Curcumin can downregulate numerous pathways, such as nuclear
factor-ϰ B (NF-ϰB), cyclooxygenase-2 (COX-2), and the canonical
WNT/β-catenin pathway. The use of curcumin, which acts as PPARγ
agonists, could be interesting in the reduction of both chronic
inflammation and oxidative stress, and in the control of
circadian clock by inhibiting the WNT/β-catenin pathway. Due to
the considerable impact of cancers on mortality and morbidity
rates worldwide, it would appear of the utmost importance to
better understand the action of curcumin in cancers and
particularly its role in the inhibition of the major signaling
system known as the WNT/β-catenin pathway.
Discover The Proven Health Benefits Of Turmeric And
Curcumin Scoopify, July 2019 Curcumin
benefits in the prevention of the growth of the precancerous
cells in the colon. Not only this, it has been highly beneficial
in the treatment of the breast, stomach and skin cancer during
the initial phase. Curcumin has the presence of
anti-inflammatory and antioxidant properties that help in
maintaining the insulin level in the body.
Feed addition of curcumin to laying hens showed
anticoccidial effect, and improved egg quality and animal health Pubmed, July 2019 The addition of curcumin in the diet of
laying hens has an anticoccidial effect and improves egg
quality.
Curcumin Induces Oxidative Stress in Botrytis
cinerea
Pubs.acs.org,
July 2019 Curcumin exhibits efficient antimicrobial
activity; nevertheless, its effect on the postharvest decay of
fruit has not been examined. Curcumin can be used to control
gray mold and elevate antioxidant activity in kiwifruit.
Health Benefits of Turmeric & Curcumin OrganicFats.net June 2019 The amazing health benefits of
turmeric and curcumin include the ability to reduce
inflammation, heal wounds, improve skin health, protect
cognitive abilities, and ease menstrual difficulties. Turmeric
also helps eliminate depression, alleviate pain, slow down
aging, protect the digestive tract, and prevent cancer. Turmeric
rich in curcumin and vitamin B6 also boosts your cardiovascular
health. Vitamin B6 can efficiently inhibit the production of
homocysteine, which is a negative by-product that damages cell
walls. These weakened walls can cause a number of complications
in the heart, particularly when exacerbated by high blood
pressure or plaque build-up. Curcumin directly balances your
cholesterol levels by eliminating excess LDL (bad) cholesterol
from the arteries and blood vessels. This can help prevent
atherosclerosis and when combined with stronger blood vessels,
the herb represents a comprehensive solution for a wide range of
heart issues, as per a study cited in the Basic Research in
Cardiology. Anti-cancer Properties A study conducted on mice by
the researchers at the Cancer Research Institute, Tata Memorial
Center, Mumbai, India documents the potential protective effect
of turmeric on stomach and skin cancer. The most extensive
research on turmeric’s cancer prevention effects has been in
colon cancer, whereas other types of cancer research related to
curcumin are currently underway. Additionally, an animal study
by Ramadasan Kuttan et al. (Cancer Letters Journal) indicated
that the turmeric extract and curcumin inhibited the growth of
the tumor. Researchers at The University of Texas M. D. Anderson
Cancer Center found that curcumin’s potential ability to kill
cancer cells can be used in drug development. Additional studies
need to be done to get the health benefits of this spice
pertaining to cancer. Prevents Alzheimer’s As a powerful
antioxidant herb, turmeric can stimulate neural activity and
prevent cognitive degradations, which often come in the form of
Alzheimer’s and dementia. As per a study by Srikant Mishra from
the Department of Neurology, Plummer Street, Sepulveda, CA,
curcumin is highly efficient in clearing out the amyloid plaque,
which is a major indicator of Alzheimer’s progression. A study
also found that turmeric supplements improved mood and cognitive
function in non-demented older people suffering from mild
age-related memory issues.
Evaluating the effect of curcumin for treatment of
cancer anorexia-cachexia syndrome in solid cancer patients. Journal of Clinical Oncology, June 2019 Curcumin has been
shown anti-cancer and anti-inflammatory effects, including
attenuation of CACS in animal models. Notably, patient with
curcumin had less reduction of hand-grip muscle strength on both
hands [right hand: -2.09 in curcumin versus -3.68 in placebo; p
= 0.46], [left hand: -1.24 versus -5.04; p-value = 0.12], and
basal metabolic rate than placebo group.
A network pharmacology approach to investigate the
pharmacological effect of curcumin and capsaicin targets in
cancer Journal of Proteins and Proteomics,
June 2019 Curcumin and capsaicin play a vital role in
anti-inflammatory and anti-cancer mechanism as they are used as
therapeutic drugs/adjuvants. The gene ontology analysis made it
possible to identify a library of possible cancer targets of
curcumin (34 targets) and capsaicin (35 targets). Based on
topological analysis, the unique target of curcumin and
capsaicin was proposed by identifying essential bottleneck/hub
node MAPK1. The docking results of MAPK1 with curcumin (− 7.6
kcal/mol) has shown good inhibitory effect similar to that of
standard control ulixertinib (− 8.1 kcal/mol) compared with
capsaicin (− 6.0 kcal/mol). Based on the molecular interaction,
MAPK1 identified through the network pharmacology approach could
be a probable target of curcumin and capsaicin to prevent
angiogenesis in cancer.
Curcumin reverses oxaliplatin resistance in human
colorectal cancer OncoTargets and Therapy,
June 2019 Studies have shown that curcumin regulated EMT
processes in many human cancers. The OXA-resistant cell line
HCT116/OXA was successfully established, and combination of OXA
with curcumin reduced OXA resistance in vitro. Besides, the
combination treatment inhibited the expressions of p-p65 and
Bcl-2, but increased the level of active-caspase3. In addition,
curcumin inhibited EMT via regulation of TGF-β/Smad2/3 signaling
pathway. Moreover, in vivo study confirmed curcumin could
reverse OXA resistance in CRC. Conclusion: Our study indicated
that curcumin could reserve OXA resistance in CRC through
dampening TGF-β/Smads signaling in vitro and
in vivo.
Curcumin suppresses epithelial-to-mesenchymal
transition of peritoneal mesothelial cells
Cellular & Molecular Biology Letters, June 2019 urcumin
reversed growth inhibition and migration capability of human
peritoneal mesothelial cells (HPMCs). In HMrSV5 cells, high
glucose PDS also decreased expression of epithelial markers, and
increased expression of mesenchymal markers, a characteristic of
EMT. Real-time RT-PCR and western blot revealed that, compared
to the 4.25% Dianeal treated cells, curcumin treatment resulted
in increased expression of E-cadherin (epithelial marker), and
decreased expression of α-SMA (mesenchymal markers) (P < 0.05).
Furthermore, curcumin reduced mRNA expression of two
extracellular matrix protein, collagen I and fibronectin.
Curcumin also reduced TGF-β1 mRNA and supernatant TGF-β1 protein
content in the PDS-treated HMrSV5 cells (P < 0.05). Furthermore,
it significantly reduced protein expression of p-TAK1, p-JNK and
p-p38 in PDS-treated HMrSV5 cells. Conclusions. Our results
demonstrate that curcumin showed an obvious protective effect on
PDS-induced EMT of HMrSV5 cells and suggest implication of the
TAK1, p38 and JNK pathway in mediating the effects of curcumin
in EMT of MCs.
Curcumin and Intestinal Inflammatory Diseases:
Molecular Mechanisms of Protection International Journal of Molecular Sciences, June 2019 Curcumin, the biologically active, hydrophobic, phenolic
component of turmeric (Curcuma longa), is a natural product
commonly utilized in Ayurdevic and traditional medicine, both
topically and orally, for its potent effects on multiple body
systems. Curcumin, also known as diferuloylmethane, has been a
popular supplement largely because of its affordability and
safety, with no known toxic side effects in humans up to doses
of 12 g/day. In this review, we discussed the potential
protective effects of curcumin on intestinal inflammatory
diseases. Recent research has focused on the effects of natural
anti-inflammatories, such as curcumin, on intestinal
inflammatory diseases, largely due to their safety profile and
affordability. Curcumin is characterized by beneficial effects
on the microbiome, antimicrobial properties, inhibition of
TLR4/NF-κB/AP-1 signal transduction, changes in cytokine
profiles, and alterations to immune cell maturation and
differentiation. The culmination of the vast number of effects
of curcumin on the intestinal epithelium and immune system is to
strengthen the intestinal barrier through a reduction in
bacterial translocation and inflammation. Curcumin may play a
significant role in intestinal inflammatory disease treatment in
the future, particularly as an adjuvant therapy.
Curcumin and its Potential for Systemic Targeting of
Inflamm-Aging and Metabolic Reprogramming in Cancer International Journal of Molecular Sciences, June 2019 The
natural source of curcumin is the rhizome of the medicinal
plant, Curcuma longa, a perennial herb in the family
Zingiberaceae. The curcuminoid complex, found in the rhizome of
turmeric (2.5–6%) contains: curcumin (CUR - diferuloylmethane,
~85%); demethoxycurcumin (DEM, ~15%); bis-demethoxycurcumin
(bis-DEM, ~5%) and cyclocurcumin. Pleiotropic effects of
curcumin have been the subject of intensive research. The
interest in this molecule for preventive medicine may further
increase because of its potential to modulate inflamm-aging.
Curcumin’s binding to various proteins, which was shown to be
dependent on cellular oxidative status, is yet another feature
for exploration in depth. Finally, the binding of curcumin to
various metabolic enzymes is crucial to curcumin’s interference
with powerful metabolic machinery, and can also be crucial for
metabolic reprogramming of cancer cells. This review offers a
synthesis and functional links that may better explain older
data, some observational, in light of the most recent findings
on curcumin.
Curcumin: A Potent Protectant against Esophageal and
Gastric Disorders International Journal of
Molecular Sciences, June 2019 Turmeric obtained from the
rhizomes of Curcuma longa has been used in the prevention and
treatment of many diseases since the ancient times. Curcumin is
the principal polyphenol isolated from turmeric, which exhibits
anti-inflammatory, antioxidant, antiapoptotic, antitumor, and
antimetastatic activities. The existing evidence indicates that
curcumin can exert a wide range of beneficial pleiotropic
properties in the gastrointestinal tract, such as protection
against reflux esophagitis, Barrett’s esophagus, and gastric
mucosal damage induced by nonsteroidal anti-inflammatory drugs
(NSAIDs) and necrotizing agents. The role of curcumin as an
adjuvant in the treatment of a Helicobacter pylori infection in
experimental animals and humans has recently been proposed. The
evidence that this turmeric derivative inhibits the invasion and
proliferation of gastric cancer cells is encouraging and
warrants further experimental and clinical studies with newer
formulations to support the inclusion of curcumin in cancer
therapy regimens. Curcumin, the natural phenolic active
ingredient of turmeric (Curcuma longa) rhizome, has been used in
Asia as an herbal remedy for a variety of diseases. In addition
to the use of curcumin as an anti-inflammatory in ancient times,
it has also been used to treat gastrointestinal (GI) diseases
such as indigestion, flatulence, diarrhea, and even gastric and
duodenal ulcers. Recently, great attention has been paid to the
medical applications of curcumin in the treatment of human
diseases associated with oxidative stress and inflammation,
including different cancers. Curcumin treatment has also led to
the improvement of metabolic parameters involving
aging-associated diseases such as atherosclerosis, diabetes,
cardiovascular disease, and chronic kidney diseases.
Interestingly, some promising effects of curcumin have been
observed in the alleviation by this turmeric derivative of the
chronic inflammatory conditions such as arthritis, uveitis, and
inflammatory bowel disease. In some instances, curcumin has been
found to aid in the prevention and treatment of various cancers.
Recently, the anticarcinogenic activity of curcumin has been
documented in the GI tract because this compound has proven to
exert a therapeutic effect on different human GI cancers such as
esophageal, gastric, and small and large intestinal cancer.
Curcumin in Autoimmune and Rheumatic Diseases Nutrients, June 2019 Curcumin is the main component of
turmeric, also known as the Curcuma longa, which belongs to the
ginger family, Zingiberaceae. Curcumin is commonly used in
Indian and Asian cooking as a spice for its flavor and yellow
color profile. In addition to its consumption due to flavor,
curcumin has been used for its medicinal properties for
thousands of years. The curcuminoids found in turmeric are
curcumin, desmethoxycurcumin, and bisdemethoxycurcumin, with
curcumin being the main active component. Curcumin was first
isolated from turmeric in 1815. Curcumin gives turmeric its
yellow color and is known to possess most of the therapeutic
effects of turmeric. In 1937, the first article published on the
use of curcumin in treating human disease cited its beneficial
effects in biliary disease. Since then, continued research has
shown that curcumin can alleviate a number of human diseases.
Studies performed on animals have shown a direct relationship
between increased cellular curcumin concentrations and its
ability to modulate inflammatory mediators. Experimental studies
on cell lines and humans have confirmed the findings from animal
studies, demonstrating that curcumin plays a role in
anti-inflammatory response via inhibition of the COX-2 pathway
and NF-kB activation. In more recent years, numerous studies
have shown that curcumin possesses potential anti-inflammatory,
anti-oxidant, anti-diabetic, and anti-cancer properties. These
studies indicate that curcumin acts on numerous targets with
various mechanisms of action, altering enzyme, receptor, and
transcription factor activity. In addition, curcumin
administration has reported nearly no side effects, making it a
potential alternative to NSAIDs and other medications with known
severe adverse effects. Curcumin has been used in Indian and
Asian medicine for its therapeutic abilities for thousands of
years. Recent studies provide evidence that increased curcumin
levels can modify cellular disease mechanisms toward a more
anti-inflammatory profile. This mainly occurs by inhibition of
the COX and lipoxygenase pathway. Additionally, curcumin
suppresses NF-κB pathway to decrease inflammation. In addition
to its anti-inflammatory effects, curcumin also exerts
anti-oxidative capacity. The involvement of these pathways in
normal rheumatic disease progression could possibly explain
curcumin’s therapeutic effects targeting these disease
processes. Many positive outcome clinical trials in OA present
solid evidence of curcumin’s beneficial role in disease
progression. In addition, curcumin shows similar efficacy to
common NSAIDs such as ibuprofen, which cause serious GI side
effects. Conversely, curcumin has shown to have little or no
side effects.
Foods That Help Fight Anxiety News 18, June 2019 Turmeric: The spice contains curcumin, a
compound that promotes brain health and prevents anxiety
disorders. Curcumin may boost omega-3 fatty acid DHA in the
brain by helping the body produce it more effectively. Curcumin
also has powerful antioxidant and anti-inflammatory properties
that help prevent damage to brain cells.
The effect of ultraviolet radiation and the
antioxidant curcumin on the longevity, fertility, and physical
structure of Drosophila melanogaster Emerging Investigators, June 2019 Curcumin significantly
prolonged lifespan and enhanced fertility for both UV- and
non-UV-exposed flies. Therefore, we conclude that curcumin can
prolong lifespan, enhance fertility, and mitigate the
deleterious effects of UV radiation on Drosophila. Our research
demonstrates that we can harness the positive potential of
natural antioxidants and use them as weapons in our war against
radiation-induced diseases, including conditions like cancer.
The Inhibitory Effect of Curcumin on Ornithine
Decarboxylase against Hepatic Carcinoma Journal of Biosciences and Medicines, June 2019 Curcumin the
active component of turmeric is widely used as an anticancer
agent for treating many human cancers. Our results showed that
curcumin has the ability to inhibit the proliferation of HepG2
cells with IC50 of 24.79 μg/ml and induced G2/M cell cycle
arrest. Moreover, it caused an elevation in the intracellular
concentration of Ca2+. Moreover, in the curcumin administration
the downregulation expression level of ODC and Bcl-2 genes (p ≤
0.05) was significant found. On the other hand, upregulation in
the expression level of P53, Bax, and caspase-3 genes (p ≤
0.05). This study concluded that curcumin may be considered as a
new saving candidate for the future progress of antitumor
agents.
Nutrition and Wound Healing: An Overview Focusing on
the Beneficial Effects of Curcumin International Journal of Molecular Sciences, July 2019 Anti-inflammatory and antioxidant properties of curcumin might
reduce the expression of tumor necrosis factor alpha (TNF-α) and
interleukin-1 (IL-1) and restore the imbalance between reactive
oxygen species (ROS) production and antioxidant activity. Since
curcumin induces apoptosis of inflammatory cells during the
early phase of wound healing, it could also accelerate the
healing process by shortening the inflammatory phase. Moreover,
curcumin might facilitate collagen synthesis, fibroblasts
migration, and differentiation.
These Spices May Help In Regulating Blood Pressure NDTV, June 2019 The golden spice is celebrated for housing
powerful antioxidant - curcumin - that protects against vascular
dysfunction. It also protects arteries of the heart, which gets
affected the most by high blood pressure.
Consuming turmeric
everyday can improve memory and happiness: Study
Dunya News ,May 2019
Found in turmeric, curcumin is
hailed as an anti-inflammatory with antioxidant properties, and
it has also been suggested as a possible reason that senior
citizens in India - where curcumin is somewhat of a staple -
have lower rates of Alzheimer s disease and better cognitive
performance. Published in the American Journal of Geriatric
Psychiatry, the research conducted by the University of
California Los Angeles set out to examine the effects of the
ingredient on people with mild, age-related memory loss. After
monitoring curcumin levels in their blood and undergoing
cognitive assessments and PET scans, the study found that those
who took curcumin saw significant improvement in both memory and
mood. In memory tests, the people taking curcumin improved by 28
percent over the 18 months and also showed mild improvement in
their overall disposition.
Curcumin ameliorates
atherosclerosis
Journal of Cellular Physiology, May
2019
The potential usage of curcumin in
diverse human diseases has been widely studied, including
arteriosclerosis (AS). We found that curcumin treatment
significantly reduced HMEC‐1 cells viability, migration, and the
protein levels of MMP‐2, MMP‐9, and vascular endothelial growth
factor (VEGF) in the presence or absence of ox‐LDL. Meanwhile,
the expression of VEGFR1 and VEGFR2 was repressed by curcumin.
miR‐126 was upregulated by curcumin. The abovementioned effects
of curcumin on HMEC‐1 cells were all attenuated when miR‐126 was
silenced. And also, VEGF was a target gene of miR‐126, and
curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5
signaling pathways via miR‐126. The effects of curcumin and its
regulation on miR‐126 and VEGF were confirmed in the animal
model of AS. To sum up, curcumin exerted potent anti‐AS property
possibly via upregulating miR‐126 and thereby inhibiting
PI3K/AKT and JAK2/STAT5 signaling pathways.
Curcumin and endometrial
carcinoma: an old spice as a novel agent
International Journal of Women's
Health, May 2019
The yellow Indian spice known as
curcumin has been extolled for its healing powers and has
recently been adopted for investigation by the scientific
community as a potent anti-cancerous agent. Curcumin is a bright
yellow-colored Indian spice derived from the herbaceous ginger
plant turmeric, also known as Curcuma longa.18 This spice has
been used for centuries to treat numerous diseases such as
diabetes, atherosclerosis as well as liver, rheumatoid, and
infectious diseases.18,19 Recent advances in molecular biology
have allowed a more microscopic inspection into the active
properties of this pleiotropic chemical (diferuloylmethane),
which has proven to effectively interact with numerous signaling
molecules within the body. Curcumin seems to show
antibacterial,20 anti-inflammatory,21 antioxidant,22 and
antimicrobial activities.23 In addition to all its benefits,
curcumin also possesses anti-cancerous effects by targeting
several important players in cell signaling pathways such as
p53,24 MAPKs, ERK, Ras,25 Wnt-β,26 PI3K, and Akt,27 all of which
play major roles in tumor progression. Furthermore, this herb,
in combination with other agents, is capable of disrupting the
cell cycle through its effect on cellular apoptosis by
activating caspases as well as downregulating anti-apoptotic
gene products (Bcl-X).28 Curcumin can also interact with several
molecules involved in proliferation (EGFR and AP-1),29,30
metastasis and invasion (MMP-9),31 angiogenesis (VEGF),32 and
inflammation (NF-κB, COX-2, TNF, IL-1, IL-6, IL-2, IL-8, and
IL-12, 5-LOX).33–35 Because of its multivalent potential to
target several molecules, this spice can be used on various
types of cancers including colorectal, leukemia, lymphoma,
breast, pancreatic, ovarian, head and neck, lung, prostate, and
melanoma.34 An investigation into the available literature
concerning curcumin as a potential therapy for cancers of the
female reproductive system turned up with no paper studying the
effect of curcumin on endometrial carcinoma. Therefore, this
review is written to shed light and summarize any available data
on the effect of curcumin as a promising therapeutic agent on
this specific gynecological cancer.
Curcumin induces cell
death in human ovarian cancer
Gynecologic Oncology, May 2019
Curcumin (Cur), a yellow-colored
dietary flavor from the plant (Curcuma longa), has been
demonstrated to potentially resist diverse diseases, including
ovarian cancer, but drug resistance becomes a major limitation
of its success clinically. The key molecule or mechanism
associated with curcumin resistance in ovarian cancer still
remains unclear. The aim of our study was to investigate the
effects of curcumin on autophagy in ovarian cancer cells and
elucidate the underlying mechanism. Curcumin reduced cell
viability and induced apoptotic cell death by MTT assay in human
ovarian cancer cell lines SK-OV-3 and A2780 significantly.
Electron microscopy, western blot and immunofluorescence
staining proved that curcumin could induce protective autophagy.
Curcumin can induce protective autophagy of human ovarian cancer
cells by inhibiting the AKT/mTOR/p70S6K pathway, indicating the
synergistic effects of curcumin and autophagy inhibition as a
possible strategy to overcome the limits of current therapies in
the eradication of epithelial ovarian cancer.
Curcumin as Antipsychotic
Treatment in Patients With Chronic Schizophrenia: A Randomized,
Double-Blind, Placebo-Controlled Study
Clinical Neuropharmacology, May 2019
Curcumin is a natural polyphenol,
which has a variety of pharmacological activities, including
antioxidative and neuroprotective effects. The studies showed
that curcumin improved the negative symptoms of schizophrenia.
There was a significant response to curcumin within 6 months in
total PANSS (P = 0.02) and in the negative symptoms subscale (P
= 0.04). The promising results of curcumin as an add-on to
antipsychotics in the treatment of negative symptoms may open a
new and safe therapeutic option for the management of
schizophrenia.
Curcumin exhibits an
antiviral activity
Antiviral Research, May 2019
Curcumin, a polyphenol, is the main
bioactive compound in dietary spice turmeric curcuma longa. It
possesses anti-inflammatory, anti-oxidant and anti-neoplastic
properties and shows potentials in treating or preventing
particular diseases such as oxidative and inflammatory
conditions, metabolic syndrome, arthritis, anxiety,
hyperlipidemia and cancers. This discovery explains the wide
range of effects of curcumin on diverse human diseases and
predicts a potential application in treatment of viral infection
and virus-associated cancer. As a proof-of-concept, we
demonstrated that curcumin is able to efficiently block Kaposi's
sarcoma-associated herpesvirus replication and inhibit the
pathogenic processes of angiogenesis and cell invasion. An
enzymatic assay confirmed that curcumin is an inhibitor of APE1
redox function. Through inhibiting APE1 redox function, curcumin
prevents c-jun/c-fos from binding to the AP-1 promoter. Through
blocking AP-1 transcriptional activity, curcumin efficiently
inhibits KSHV lytic DNA replication and virion production.
Curcumin also inhibits KSHV-mediated pathogenesis including
angiogenesis and cell invasion.
Curcumin Can Improve
Spinal Cord Injury
Cellular and Molecular Neurobiology,
May 2019
Curcumin exhibits potent
anti-inflammatory and anti-oxidant properties. Curcumin can play
an important role in SCI recovery by inhibiting the expression
of NF-κB and TGF-β-SOX9. Herein, we review the potential
mechanism of curcumin-inhibiting SOX9 signaling pathway in SCI
treatment. The inhibition of NF-κB and SOX9 signaling pathway by
curcumin has the potentiality of serving as neuronal
regenerative mechanism following SCI.
Effect of combined fish oil &
Curcumin on murine skeletal muscle
Nutrition Research, May 2019
Nutritional supplements such as fish
oil and curcumin enhance anabolic signaling, glutathione levels,
and heat shock proteins. We hypothesized that fish oil, rich in
omega-3-fatty acids, combined with the polyphenol curcumin would
enhance stress protective proteins and anabolic signaling in the
rat soleus muscle, concomitant with synergistic protection of
morphology. C57BL/6 mice were assigned to 3 groups
(n = 6/group): ambulatory controls (CON), hindlimb unloading
(HU), and hindlimb unloading with 5% fish oil, 1% curcumin in
diet (FOC). FOC treatments began 10 days prior to HU and tissues
were harvested following 7 days of HU. FOC mitigated the
unloading induced decrease in CSA. FOC also enhanced abundance
of HSP70 and anabolic signaling (Akt phosphorylation, p70S6K
phosphorylation), while reducing Nox2, a source of oxidative
stress. Therefore, we concluded that the combination of fish oil
and curcumin prevents skeletal muscle atrophy due to a boost of
heat shock proteins and anabolic signaling in an unloaded state.
Curcumin reduces renal
damage
Federation of American Societies for
Experimental Biology, May 2019
Treatment with curcumin initiated
before or after rhabdomyolysis induction ameliorated all these
pathologic and molecular alterations. In cultured renal tubular
cells, myoglobin (Mb) induced ferroptosis-sensitive cell death
that was also inhibited by curcumin. Mechanistic in vitro
studies showed that curcumin reduced Mb-mediated inflammation
and oxidative stress by inhibiting the TLR4/NF-κB axis and
activating the cytoprotective enzyme heme oxygenase 1. Our
findings are the first to demonstrate the involvement of
ferroptosis in rhabdomyolysis-associated renal damage and its
sensitivity to curcumin treatment. Therefore, curcumin may be a
potential therapeutic approach for patients with this syndrome.
Curcumin induces
apoptosis in JAK2‐mutated cells
Journal of Cellular and Molecular
Medicine, May 2019
Previous studies showed that
curcumin, the active principle of the Curcuma longa, can
suppress JAK2/STAT pathways in different type of cancer and
injuries. In this study, we investigated the anti‐proliferative
and pro‐apoptotic effects of curcumin in JAK2 V617F‐mutated
cells. HEL cell line and cells from patients JAK2 V617F mutated
have been incubated with increasing concentrations of curcumin
for different time. Apoptosis and proliferation were evaluated.
Subsequently, JAK2/STAT and AKT/mTOR pathways were investigated
at both RNA and protein levels. We found that curcumin induces
apoptosis and inhibition of proliferation in HEL cells.
Furthermore, we showed that curcumin inhibits JAK2/STAT and
mTORC1 pathways in JAK2 V617F‐mutated cells. This inhibition
suggests that curcumin could represent an alternative strategy
to be explored for the treatment of patients with
myeloproliferative neoplasms.
Curcumin: a potent agent to
reverse epithelial-to-mesenchymal transition
Cellular Oncology, May 2019
Accumulating evidence indicates that
curcumin, as a well-known phytochemical, can inhibit
EMT/metastasis through various mechanisms and pathways in human
tumors. Curcumin can exert chemo-preventive effects by
inhibition and reversal of the EMT process through both
TGF-β-dependent (e.g. in hepatoma and retinal pigment epithelial
cancer) and -independent (e.g. in oral cancer, colorectal
cancer, pancreatic cancer, hepatocellular carcinoma, breast
cancer, melanoma, prostate cancer, bladder cancer, thyroid
cancer and lung cancer) pathways. Curcumin can also mitigate
chemoresistance through EMT suppression and promotion of the
antiproliferative effects of conventional chemotherapeutics.
Therefore, curcumin has the potential to be used as a novel
adjunctive agent to prevent tumor metastasis, which may at least
partly be attributed to its hampering of the EMT process.
The Brain And Memory
Herbal Remedies Home, May 2019
Curcumin has been linked to a lower
dementia risk numerous times before. According to a 2009 study
done by researchers from Duke University, it causes brain
changes and reverses some of the effects of Alzheimer’s disease.
Namely, it targets the amyloid plaques, which are considered to
be one of the main causes of brain damage. The researcher Murali
Doraiswamy said: “There is very solid evidence that curcumin
binds to plaques, and basic research on animals engineered to
produce human amyloid plaques has shown benefits. You can modify
a mouse so that at about 12 months its brain is riddled with
plaques. If you feed this rat a curcumin-rich diet, it dissolves
these plaques. The same diet prevented younger mice from forming
new plaques.” The active ingredient of turmeric, curcumin, is
responsible for most of its medicinal and healing powers, since
it is full of antioxidants and offers extremely powerful
anti-inflammatory properties. According to Dr. Josh Axe, DC,
DMN, CNS: “Arguably, the most powerful aspect of curcumin is its
ability to control inflammation. The journal Oncogene published
the results of a study that evaluated several anti-inflammatory
compounds and found that aspirin and ibuprofen, two of the most
common NSAIDs (non-steroidal anti-inflammatory drugs) are least
effective, while curcumin is among the most effective
anti-inflammatory compounds in the world. This news should have
reached every household in the world after the study was
conducted because inflammation is at the root of most diseases.
Increasingly common diseases today — such as cancer, ulcerative
colitis, arthritis, high cholesterol, and chronic pain — are all
associated with inflammation. The anti-inflammatory effects of
curcumin have also been studied as a possible treatment for
Alzheimer’s disease. “ Moreover, this amazing spice improves
health in a thousand other ways, cleanses the blood, prevents
premature aging, detoxifies the liver, prevents free radical
damage, improves skin health, and much more. Also, a series of
2013 studies done at the University of Tsukuba in Japan showed
that curcumin improved two measures of cardiovascular health as
much as aerobic exercise did. Also, numerous studies have
confirmed that turmeric and curcumin will help you soothe
arthritis, reduce body fat, prevent cancer, and improve cancer
prognosis. Its anti-cancer activity has been studied and
confirmed by numerous studies. Dr.Mercola reports: “ Curcumin
actually has the most evidence-based literature supporting its
use against cancer of any other nutrient, including vitamin D!
As noted by Dr. William LaValley, curcumin is unique in that it
appears to be universally useful for just about every type of
cancer. This is odd, considering the fact that cancer consists
of a wide variety of different molecular pathologies. One reason
for this universal anti-cancer proclivity is curcumin’s ability
to affect multiple molecular targets, via multiple pathways.
Once it gets into a cell, it affects more than 100 different
molecular pathways. And, as explained by Dr. LaValley, whether
the curcumin molecule causes an increase in activity of a
particular molecular target, or decrease/inhibition of activity,
studies repeatedly show that the end result is a potent
anti-cancer activity. Moreover, curcumin is non-toxic and does
not adversely affect healthy cells, suggesting it selectively
targets cancer cells—all of which are clear benefits in cancer
treatment. Research has even shown that it works synergistically
with certain chemotherapy drugs, enhancing the elimination of
cancer cells.”
Effects of Curcumin on
Microglial Cells
Neurotoxicity Research, May 2019
Curcumin is a phytochemical isolated
from Curcuma longa. It is widely used in Asia and has many
therapeutic properties, including antioxidant, anti-viral,
anti-bacterial, anti-mutagenic, anti-amyloidogenic and
anti-inflammatory, especially with respect to neuroinflammation
and neurological disorders (NDs). Curcumin is a pleiotropic
molecule that inhibits microglia transformation, inflammatory
mediators and subsequent NDs. In this mini-review, we discuss
the effects of curcumin on microglia and explore the underlying
mechanisms.
Curcumin may help in
some UC patients
MDedge.com May 2019
Curcumin was evaluated in a
multicenter trial showing that, when added to maximal
mesalamine, it may be helpful in avoiding an advance in therapy,
with 54% achieving clinical remission at week 4 versus 0% of
placebo-treated patients. Likewise, curcumin has shown “minimal
harm” in mild ulcerative colitis and may help nudge patients
toward disease control without having to resort to
corticosteroids or other immunosuppressive therapy, Dr. Brant
said.
Study highlights
anti-tumor activity of curcumin on stomach cancer
Eureka Alert, May 2019
Curcumin is widely used to impart
color and flavor to food, but scientists have discovered that
this yellow powder derived from the roots of the turmeric plant
(Curcuma longa) can also help prevent or combat stomach cancer.
Curcumin influences histone modifications primarily by
inhibiting HATs and HDACs to suppress cancer cell proliferation
and induce apoptosis (programmed cell death). Garcinol, whose
chemical structure resembles that of curcumin, inhibits HATs and
helps prevent stomach cancer by neutralizing free radicals.
Best supplements for
arthritis: Natural remedies to alleviate joint pain
Express, May 2019
Turmeric contains a chemical called
curcumin, which can reduce pain and swelling by blocking
inflammatory cytokines and enzymes. A clinical trial using a
turmeric supplement in 2010 showed long-term improvement in pain
and function in patients with osteoarthritis of the knee, A
small study in 2012 using a curcumin product also showed more
reduced joint pain and swelling in patients with active
rheumatoid arthritis, when compared to diclofenac sodium.
Stop Different Types of
Pain
Trending Posts, May 2019
Curcumin to stop the pain caused by
inflammation. Curcumin is a natural proven remedy well known for
its anti-inflammatory properties. One of the most popular spices
of Asia is Turmeric and it can be widely used in medicines
because its components contain anti-inflammatory properties.
Comparisons between conventional medications and curcumin have
been researched and it has been proved that curcumin is just as
good as ibuprofen for relieving pain. Turmeric or curcumin
capsules are being recommended by doctors for patients suffering
from aches and sore joints.
Curcumin combined with
metformin decreases glycemia and dyslipidemia, and increases
paraoxonase activity
Diabetology & Metabolic Syndrome,
May 2019
Curcumin, a yellow pigment isolated
from Curcuma longa rhizomes, has gained attention due to its
beneficial effects in controlling the disturbances observed in
diabetes mellitus. Treatment of diabetic rats with curcumin or
metformin alone decreased the plasma levels of glucose,
triacylglycerol, cholesterol, TBARS, and fluorescent AGEs, as
well as increased the activity of PON 1. The combination of
metformin with curcumin further decreased dyslipidemia and TBARS
levels in diabetic rats, indicating synergy, and maintained the
high levels of PON 1. These findings indicated that curcumin
combined with metformin may act synergistically on dyslipidemia
and oxidative stress, as well as increased PON 1 levels.
Therefore, it might be a promising strategy for combating
diabetic complications, mainly the cardiovascular events.
The neuroprotective
effects of curcumin
Drug
Design, Development and Therapy, May 2019
The beneficial, neuroprotective
effects of curcumin against ischemia-reperfusion injury have
been demonstrated. In the present study, whether curcumin exerts
neuroprotective effects associated with the inhibition of
autophagy and hypoxia inducible factor-1α (HIF-1α) was
investigated. In this study, curcumin decreased the death and
apoptosis of cells, and inhibited autophagy and HIF-1α under
OGD/R conditions, consistent with 3-MA treatment or HIF-1α
downregulation. Moreover, inhibition of autophagy caused a
decrease in HIF-1α, and the attenuation of HIF-1α induced
autophagy suppression under OGD/R conditions. The results of
this study showed that curcumin exerts neuroprotective effects
against ischemia-reperfusion, which is associated with the
regulation of the reciprocal function between autophagy and
HIF-1α.
Curcumin supplementation
mitigates NASH development
Physiological Reports, May 2019
Curcumin, a naturally occurring
plant polyphenolic compound, may have beneficial effects in
nonalcoholic steatohepatitis (NASH) development. Curcumin
treatment (12WD vs. 12WD+C) reduced (P < 0.05) hepatocellular
inflammation, steatosis, NAFLD Activity Scores, and serum
markers of liver injury (AST, ALP). Moreover, curcumin treatment
also increased hepatic pACC/ACC, ApoB100, and SOD1 protein, and
decreased hepatic FGF‐21 levels; whereas, curcumin prevention
increased hepatic glutathione levels. Both curcumin prevention
and treatment reduced molecular markers of hepatic fibrosis
(Col1a1 mRNA) and inflammation (TNF‐α, SPP1 mRNA). Curcumin
supplementation beneficially altered the NASH phenotype in
female Wistar rats, particularly the reversal of hepatocellular
inflammation.
The study identifies the
possible therapeutic effects of curcumin on gastric cancer
Onties.com May 2019
"We made a huge overview of the
scientific literature on all nutrients and bioactive compounds
with the potential to prevent or treat stomach cancer and found
that curcumin is one of them," said Daniel Ciroz Calgano, a
professor at UFPA.
What Are Nootropics?
Your Guide To The Best Brain-Boosting Nutrients
Mind Body Green, May 2019
You may have 99 problems, but
curcumin has probably already solved 98 of them—and you can add
improved cognitive performance to that list. This compound in
turmeric has been shown to improve working memory with
consistent long-term supplementation. Curcumin can also increase
BDNF, reduce oxidative stress, and inhibit inflammatory
cytokines.
Daily dose of turmeric
could boost memory, mood: study
Pan Armenian, May 2019
Curcumin, the compound that gives
the spice its rich dark yellow colour, is widely established to
have anti-inflammatory and antioxidant properties. The research,
published in the American Journal of Geriatric Psychiatry,
examined the effects of curcumin on memory performance in people
without dementia, as well as its impact on people already
suffering from Alzheimer’s disease. “Exactly how curcumin exerts
its effects is not certain, but it may be due to its ability to
reduce brain inflammation, which has been linked to both
Alzheimer’s disease and major depression,”. Memory tests showed
that those taking curcumin improved by 28 percent over the 18
months and experienced mild improvements in mood. "These results
suggest that taking this relatively safe form of curcumin could
provide meaningful cognitive benefits over the years,” said Dr
Small.
Study reveals turmeric
is more effective at killing cancer cells than chemo or
radiation
El Reportero, May 2019
One aspect of curcumin’s intelligent
approach is its ability to downregulate interleukin-6. The
over-expression of this cytokine has been linked to inflammation
progressing to cancer, and curcumin stops it from being released
and stimulating cancer stem cells. It also directly and
indirectly downregulates interleukin-1, which plays a vital role
in the growth of cancer cells, and interleukin-8, which
stimulates the regrowth of tumor-forming cancer stem cells.
Another way curcumin can fight cancer is by decreasing the
binding of CXCR1 and CXCR2 and modulating pathways like the Wnt
Signaling Pathway, the Notch Pathway, the FAK/AKT/FOXo3A
Pathway, and the Hedgehog Pathways. If those terms are
unfamiliar to you, you’re not alone – cancer is a complicated
disease, but the bottom line is that curcumin targets deadly
cancer stem cells in eight different and very powerful ways.
Curcumin is a very efficient cancer fighter, targeting the most
dangerous cells of all, cancer stem cells, without touching
normal cells. Contrast this with chemotherapy, which damages the
DNA of quickly-replicating cells while they’re vulnerable during
the mitosis stage of cell division. It does this without
determining if the cells are cancerous or completely healthy.
Healthy Options: Root
Plants And Herbal Leaves For Stress And Anxiety Management
TG Daily, May 2019
Turmeric root, on the other hand,
also has very promising benefits for the effective management of
stress and anxiety disorders. Both animal studies and human
studies conclude that the oral intake of curcumin can
significantly prevent anxiety-like behavior and improve
mobility.
Study: Curcumin,
Resveratrol Possible Anti-Cancer Compounds
Whole Foods Magazine, May 2019
Curcumin can play a role in
preventing stomach cancer, according to a new study from
researchers at the Federal University of São Paulo (UNIFESP) and
the Federal University of Pará (UFPA).
High blood pressure -
best spices to prevent deadly hypertension symptoms
Express, May 2019
Turmeric’s active ingredient,
curcumin, could play a role in lowering blood pressure,
according to cardiologist Dr Stephen Sinatra.Curcumin is a
powerful antioxidant the helps to break-up big clumps of
platelets in the blood, he said. If you’d prefer to take
curcumin as a supplement, aim for around 500mg in a single day.
ou may not have heard of curcumin before, but you have probably
heard of turmeric, the spice that is best known as an ingredient
in Indian curry and yellow mustard. Turmeric has been my number
one natural blood pressure reducer and cardiovascular spice for
years, and its yellow colour comes from curcumin — a powerful
antioxidant and anti-inflammatory compound that’s been found to
reduce blood pressure by lowering the excess platelet
aggregation that occurs in sticky, clot-forming blood.
Is the Curcumin in
Turmeric More Effective Than Prozac for Depression?
Tmd.org May 2019
Curcumin is the main compound in the
spice, turmeric. This spice is known for its bright yellow or
orange color, flavorful taste, and is a great addition to
curries. It is also well known in traditional medicine for its
healing properties and has been used for centuries to heal many
conditions. Curcumin possesses both anti-inflammatory and
antioxidant properties. Beyond fighting common
inflammatory-related conditions, such as arthritis and cancer,
curcumin has been researched for its potential role in treating
depression. One study found that curcumin therapy successfully
reduces depressive symptoms when compared to the leading
antidepressant medication, Prozac. What set curcumin apart was
the fact that little to no side effects were reported.
Antidepressants can cause any number of side effects including
nausea, vomiting, blood pressure changes, dizziness, anxiety,
and weight gain. With curcumin being more natural, these side
effects can be avoided, and the depression itself can be
successfully treated. Studies continue to research the
effectiveness of curcumin on depression. With all this said,
antidepressant medication is still preferred for good reasons,
and these should be discussed with your physician. Do not stop
taking prescribed medication before consulting with your doctor.
The Natural Approach to Fighting Depression Curcumin is a strong
antioxidant which means it scavenges and rids the body of
harmful free radicals. The reduction of oxidative damage also
reduces inflammation, and this can alleviate depressive
symptoms. Studies have found a link between inflammation and
depression but are not entirely which is the cause and which the
result. The relationship does, however, tell us that by reducing
inflammation, you can also reduce the symptoms of depression.
Depression has also been scientifically linked to reduced
production of BDNF (brain-derived neurotrophic factor), a growth
hormone that impacts the function of your brain. Curcumin
increases the presence of BDNF in the brain, which can lead to a
reduction is depressive symptoms or a reduced risk of developing
the disease. Curcumin has also been linked to increased
production of the neurotransmitters serotonin and dopamine.
Anxiety is another common mental disease that exists alongside
depression in many cases. Curcumin has been found to increase
the production of DHA, an essential omega-3 fatty acid.
Deficiency in this omega-3 has been linked to increased anxiety,
which can trigger or cause depression. By reducing anxious
thoughts or behaviors, curcumin can also help reduce depression.
Why you should be adding
turmeric daily to your life
Mustafa Mehar, May 2019
There have been over 50 clinical
trials done on the health benefits of turmeric and curcumin and
it seems there are only more coming our way. Below is a summary
of some of the studies and their claims. The major health
benefits of Turmeric 1. It plays a major role in cancer
prevention, including myeloma, pancreatic, colon, breast, brain,
blood, kidney, liver, pancreas and skin cancer. This is due to
the fact that it can help prevent the initial processes that
lead to mutations within our DNA. 2. It has major
anti-inflammatory effects, according to a study which researched
the efficacy of curcumin in the treatment for rheumatoid
arthritis. It has been found to treat other inflammatory
conditions effectively as well. 3. Turmeric plays a preventative
role in the development of multiple diseases, such as lung
disease and brain disease, and has been found to improve brain
function. 4. It is beneficial for your cardiovascular health,
supplementing daily with turmeric has been found to have as many
benefits in improving our cell function in the arteries as one
hour of aerobic exercise. 5. It is believed that turmeric may
play a role in preventing Alzheimers disease. This condition is
related to a build up of Amyloid-Plaques in the brain, and
curcumin has been found to aid in removing these build ups. 6.
Curcumin acts as a natural anti-depressant, where studies show
it increases the brain’s serotonin and dopamine levels, as well
as increasing brain-derived neurotrophic factor levels (BDNF).
Low levels of BDNF has been associated with depression. 7. It
offers anti-aging benefits. Oxidation and inflammation within
the body are linked to aging and curcumin, a powerful
anti-oxidant, potentially preventing these processes from
occurring within the body. 8. Turmeric may also benefit your
skin. The anti-inflammatory and antioxidant properties can aid
with skin health, such as eczema or psoriasis.
Protective effects of curcumin
in embryonic fibroblast cells
Journal of Biochemical and Molecular
Toxicology, May 2019
The study indicated that curcumin
might be a potential ameliorative antioxidant to protect the
fibroblast cell toxicity induced by sodium arsenite.
Revealing the Effects of
Curcumin on SH-SY5Y Neuronal Cells: A Combined Study from
Cellular Viability, Morphology, and Biomechanics
Journal of Agricultural and Food
Chemistry, May 2019
The present study provides insights
into the effects of curcumin on neuronal cells from both
biological and biophysical aspects, which can help more
comprehensively understand the interactions between curcumin and
SH-SY5Y cells.
Safety and efficacy of
curcumin versus diclofenac in knee osteoarthritis: a randomized
open-label parallel-arm study
Trials, May 2019
At days 14 and 28, patients
receiving curcumin showed similar improvement in severity of
pain and KOOS scale when compared with diclofenac, and the
difference was not statistically significant. At day 7, the
patients who received curcumin experienced a significantly
greater reduction in the number of episodes of flatulence
compared with diclofenac (P <0.01). At day 28, a weight-lowering
effect (P <0.01) and anti-ulcer effect (P <0.01) of curcumin
were observed. None of the patients required H2 blockers in the
curcumin group, and 19 patients required H2 blockers in the
diclofenac group (0% versus 28%, respectively; P <0.01). Adverse
effects were significantly less in the curcumin group (13%
versus 38% in the diclofenac group; P <0.01). Patient’s and
physician’s global assessment of therapy was similar in the two
treatment groups. Curcumin has similar efficacy to diclofenac
but demonstrated better tolerance among patients with knee OA.
Curcumin can be an alternative treatment option in the patients
with knee OA who are intolerant to the side effects of
non-steroidal anti-inflammatory drugs.
How Curcumin Can Help
with Memory and Conditions Like Dementia and Alzheimer’s
Life News, May 2019
The most beneficial compound found
in turmeric is curcumin, and it can help support memory
functions and contribute to a feeling of calmness and bring
relief from mental stress or strain. It has also been shown to
lessen fatigue as well as promote better heart health. Curcumin
is also known to contribute to the increase of BDNF (a brain
hormone), which then enhances the function of the brain’s
neurons, encouraging growth and promoting strength. Also, one of
the features of diseases such as dementia and Alzheimer’s is the
buildup of amyloid-beta proteins or plaque. In some studies,
curcumin was found to have the potential to obstruct the
development of this plaque.
The major health
benefits of Turmeric
Power Living, May 2019
Curcumin has major anti-inflammatory
effects, according to a study which researched the efficacy of
curcumin in the treatment for rheumatoid arthritis. It has been
found to treat other inflammatory conditions effectively as
well. It is beneficial for your cardiovascular health,
supplementing daily with turmeric has been found to have as many
benefits in improving our cell function in the arteries as one
hour of aerobic exercise. It is believed that turmeric may play
a role in preventing Alzheimers disease. This condition is
related to a build up of Amyloid-Plaques in the brain, and
curcumin has been found to aid in removing these build ups.
Curcumin acts as a natural anti-depressant, where studies show
it increases the brain’s serotonin and dopamine levels, as well
as increasing brain-derived neurotrophic factor levels (BDNF).
Low levels of BDNF has been associated with depression. It
offers anti-aging benefits. Oxidation and inflammation within
the body are linked to aging and curcumin, a powerful
anti-oxidant, potentially preventing these processes from
occurring within the body.
Remedies To Help Reduce
Inflammation
Romper, May 2019
It's almost impossible to look at
inflammatory remedies without mentioning this particular spice.
"Turmeric has been used in India for thousands of years as a
medicinal herb," says LA-based naturopath Dr. Saman Faramarzi.
As it turns out, turmeric contains curcumin, which has
anti-oxidant and anti-inflammatory properties, according to
Foods. If you want to give this spice a try, then making
turmeric milk (AKA golden milk) at home is a simple
introduction, according to Elite Daily.
The Golden Spice: 5
Incredible Haldi Benefits That Would Take You By Surprise
NDTV, May 2019
Curcumin with its amazing
anti-inflammatory abilities helps suppress chronic inflammation.
Scientific research has shown a positive co-relation between
curcumin and weight loss by preventing the growth of fat cells
and it also protects against the negative impact of obesity on
our health. Curcumin has been documented to improve insulin
sensitivity, reducing elevated BP, and controlling triglyceride
and cholesterol levels while improving HDL cholesterol.
Antioxidant and anti-inflammatory activity of curcumin is the
main reason of the health benefits of turmeric. It has been
shown to reduce oxidative stress and increase the activity of
our body's antioxidants. Curcumin has been found to have the
strongest antioxidant effects when compared with other
compounds.
Prevent Autoimmune
Diseases
Medical Daily, May 2019
People are obsessed with turmeric
supplements to fight pain and inflammation. Scientific evidence
shows that curcumin, a pigment from turmeric root, regulates
your immune system’s health and suppresses autoimmune diseases.
Anti-inflammatory foods
that reduce pain
Baltimore Post Examiner, May 2019
Turmeric has a compound known as
curcumin which has been found to be as effective as
anti-inflammatory medications. Curcumin has powerful
anti-inflammatory effects and antioxidants. It’s a better
alternative because it has no side effects like the medication
itself.
Best supplements for
diabetes
Express, May 2019
Turmeric’s active ingredient,
curcumin, could help to reduce insulin resistance, and
subsequently protect against diabetes, said registered nurse
David Spero. It improves insulin function, which allows more
insulin to get into cells, he claimed. Adding turmeric to your
diet could also lower your cholesterol and even prevent some
types of cancer, added the nurse. “One diabetes medicine may
lower blood sugar and cholesterol, protect your eyes and
kidneys, relieve pain, prevent cancer, and improve your sex
life. It also tastes good,” Spero wrote on Diabetes
Self-Management. “This medicine is turmeric, made from the root
Curcuma longa, a member of the ginger family. “Curcumin may also
help treat aspects of diabetes, both type 1 and type 2.
Best supplements for
arthritis
Expess, May 2019
Turmeric contains a chemical called
curcumin, which can reduce pain and swelling by blocking
inflammatory cytokines and enzymes. A clinical trial using a
turmeric supplement in 2010 showed long-term improvement in pain
and function in patients with osteoarthritis of the knee, A
small study in 2012 using a curcumin product also showed more
reduced joint pain and swelling in patients with active
rheumatoid arthritis, when compared to diclofenac sodium.
Foods that Help Anxiety
Care2, May 2019
Turmeric has been shown in numerous
studies to soothe both depression and anxiety. Not only do
turmeric’s powerful phytochemicals do a stellar job of
counteracting inflammation, but turmeric can help balance the
chronically activated stress response that is associated with
anxiety. Supplements of curcumin extract will be the most
therapeutic source, but it definitely doesn’t hurt to enjoy a
golden latte once in a while, either.
The One Supplement That
Will Take Your Recovery To The Next Level
Mind Body Green, May 2019
Turmeric has proven its weight in
(literal) gold with regards to fighting inflammation. That’s
because its active compound, curcumin, is anti-inflammatory and
has many preventative health benefits. And given that the root
cause of many diseases is inflammation, turmeric has risen in
popularity in both its whole, ground, and supplement form.
Reasons to Add Turmeric
to Your Diet
IBC News, May 2019
Turmeric can help you reduce
inflammation. The presence of curcumin in turmeric makes it a
good remedy to fight inflammation. It is extremely good for
arthritis patients. It can help arthritis patients treat
inflammation naturally. There are several risk factors which can
contribute to cancer. Various studies indicate that curcumin can
reduce the growth of cancerous cells. According to the studies,
turmeric consumption can help you reduce the risk of pancreatic
cancer, prostate cancer and many others. Curcumin can also
stimulate brain function and improve memory. According to
studies, turmeric can help you boost brain power. It can also
reduce the risk of Alzheimer’s disease and depression. It will
also stimulate logical thinking.
More muscles in old age
thanks to curcumin supplementation
Ergo-Log.com, April 2019
More muscles in old age thanks to
curcumin supplementation. As you get older, your body loses more
and more muscle mass. Initially the decay of your muscles is so
slow that you hardly notice it, but every year the decay process
runs a little faster than the year before. Supplementation with
curcumin, the most important bioactive substance in turmeric,
can block this process. This is evident from an animal study
that will shortly appear in the International Journal of
Molecular Sciences.
Natural food for the
prevention of cancer
The Indian Talks, April 2019
Curcumin is a component of turmeric.
Studies in mice have shown that curcumin prevents the occurrence
of tumors caused by various carcinogenic factors. Angiogenesis
is the process of forming capillaries. In the case of a cancer
that may have occurred due to earlier DNA damage, it is a
process that makes it possible to feed the cancer so that it can
develop. In this way, micro-gas is transformed into a cancer
capable of growing and attacking tissues. The purpose of
curcumin is to inhibit the formation of new blood vessels that
feed the cancer, depriving it of the possibility of taking
nutrients and developing cancer.
Turmeric outperforms
chemotherapies in treating cancer
Reports Health Care, April 2019
Curcumin is one of the active
compounds in turmeric. It is responsible for most of the
health-promoting effects offered by the spice. Curcumin,
reportedly, benefits conditions like obesity, diabetes,
cardiovascular diseases, neurological issues, cancer, and other
chronic, inflammatory diseases. One research team analyzed a
total of 19 test tube and five animal studies. They evaluated
the ability of turmeric extracts to fight or prevent
glioblastoma. The researchers found that curcumin inhibits the
growth of cancer cells and induce cell death in certain
subpopulations of glioblastoma tumors. Thus, it can serve as a
potent therapeutic agent for treating cancer. The other study
was published in the journal Nutrition and Cancer. It discovered
the possibility to get a bioactive dose of curcumin into human
glioblastoma cancer cells via oral delivery methods. Four days
before surgical removal of brain tumors, the human volunteers
for the study were given 70 milligrams of a curcuminoid
combination three times in a day. During the surgery tumor and
blood samples were collected for analyzing the curcuminoid
concentrations. The tumors were found to have detectable levels
of curcuminoids. This made the researchers conclude that oral
treatments alter the energy metabolism of tumors. Many other
studies also reveal the potent anti-cancer properties of
curcumin. However, curcumin extracts are still not being used in
cancer therapy. Researchers suggest the pharmaceutical
industries to make use of this wonder spice for treating cancer.
It can serve as a convenient, natural and safe treatment for the
condition.
How To Use Turmeric To
Fight Diabetes
Post News, April 2019
Hundreds of studies have been
conducted on curcumin (the most important component of turmeric)
and its effects on diabetes. The results about using turmeric
for diabetes have been extremely encouraging. In this post, we
talk about everything you possibly need to know about turmeric
and turmeric for diabetes can be helpful. The curcumin in
turmeric has been credited with most of its anti-diabetic
effects. It was found to lower blood glucose levels and even
fight inflammation – which is one severe effect of diabetes. One
2013 study conducted by the Beijing University of Chinese
Medicine showed how curcumin could lower the glucose levels and
help improve other diabetes-related conditions . Even turmeric
extracts (often found in pharmacies) were found to make diabetes
more manageable. And they also prevented other diabetes-related
complications like nerve damage and cataracts.
Protective effects of
amifostine, curcumin, and melatonin against cisplatin-induced
acute kidney injury
Naunyn-Schmiedeberg's Archives of
Pharmacology, April 2019
Amifostine, curcumin, and melatonin
reduced the increases in serum urea and serum creatinine levels
following cisplatin administration and reduced the levels of
TNS, HPS, NF-κB/p65, 8-OHdG, and caspase-3 expressions
(p < 0.05). ROS-scavenging antioxidants may be a promising means
of preventing acute kidney disease in patients using cisplatin
in the treatment of malignant tumors.
Nutrition: Get the
protective power of phytonutrients
Duluth News Tribune, April 2019
Curcuminoids are phytonutrients
found in turmeric root, which is a spice traditionally used in
Indian cuisine. Curcumin offers anti-inflammatory benefits and
may help prevent or treat colorectal cancer.
Health Benefits of
Turmeric
Akhabar News, April 2019
Turmeric contains curcumin, a
substance with powerful anti-inflammatory and antioxidant
properties. Most studies used turmeric extracts that are
standardized to include large amounts of curcumin. Chronic
inflammation contributes to many common Western diseases.
Curcumin can suppress many molecules known to play major roles
in inflammation. Curcumin has powerful antioxidant effects. It
neutralizes free radicals on its own but also stimulates your
body’s own antioxidant enzymes. Curcumin boosts levels of the
brain hormone BDNF, which increases the growth of new neurons
and fights various degenerative processes in your brain.
Curcumin leads to several changes on the molecular level that
may help prevent and perhaps even treat cancer. Due to its many
positive health effects, such as the potential to prevent heart
disease, Alzheimer’s and cancer, curcumin may aid longevity.
Herbs & spices with the
most powerful health benefits
New Times, April 2019
First and foremost, turmeric is an
incredible inflammation fighter. It can even make a significant
difference in individuals who suffer from rheumatic pain. This
is because of constituent curcumin – its active constituent and
yellow bioactive compound, lending turmeric its colour. Curcumin
has a wide variety of biological interactions when consumed. Its
anti-inflammatory benefits make it a good choice for healing
leaky gut, improving digestion, and addressing autoimmune issues
with inflammatory side effects. Due to curcumin’s
anti-inflammatory properties, it has the ability to slow down
inflammation-related ageing processes and diseases. Curcumin is
also effective at increasing antioxidant capacity in the body.
It’s one of the most concentrated antioxidant foods you can
consume! This means an overall reduction of oxidative stress.
Finally, curcumin can increase immunity with its antibacterial
and anti-viral properties, protect against cancer and the
development of tumours, and improve heart health.
Here's How Turmeric
Could Help Keep Inflammation At Bay
NDTV, April 2019
"Curcumin has a medicinal effect
comparable to drugs, such as hydrocortisone and phenylbutazone,
and can be used to provide relief from rheumatoid arthritis,
treat inflammatory bowel disease, protect against diabetes, and
even avoid heart disease and stroke by preventing the build-up
of plaque in the arteries," notes the book 'Healing Foods'.
Super foods every woman
should include in her diet
The Hans India, April 2019
Turmeric may be the most effective
nutritional supplement in existence. Many high-quality studies
show that it has major benefits for your body and brain.
Curcumin, a plant nutrient that gives turmeric its deep golden
hue, has long been used in Eastern medicine to treat infections
and help speed wound healing.
Turmeric: This must-have
spice found in your kitchen is full of benefits
Times of India, April 2019
Turmeric comes from the root of
Curcuma longa, a plant of the ginger family and contains
compounds with medicinal properties. These compounds are called
curcuminoids, the most important of which is curcumin. Numerous
studies suggest that this spice is beneficial for both body and
brain.
Foods to keep your
brain, memory sharp
Daily Sabah, April 2019
Turmeric: With its active ingredient
curcumin, turmeric is a strong yet natural antioxidant. This
plant, which has been used for its medical benefits throughout
history, helps your brain receive more oxygen, learn and process
information easier.
Effects of turmeric and
curcumin on oral mucositis: A systematic review
Phytotherapy Research, April 2019
The aim of this study was to
evaluate the effects of turmeric and curcumin in the management
of oral mucositis in cancer patients undergoing chemo and/or
radiotherapy. Patients treated with turmeric/curcumin
experienced reduced grade of mucositis, pain, erythema
intensity, and ulcerative area. Current evidence suggests that
topical application of turmeric or curcumin is effective in
controlling signs and symptoms of oral mucositis. Thus, further
investigation is required to confirm the promising effect of
turmeric and curcumin in oral inflammatory lesions.
Effects of Prolonged Dietary
Curcumin Exposure on Skeletal Muscle
International Journal of Molecular Sciences, April 2019
Curcumin is a phenolic compound
shown to upregulate antioxidant defenses and directly quench
RONS in vivo. Consumption of curcumin coupled with reduced food
intake imparted beneficial effects on aged skeletal muscle. The
benefit of curcumin on aging skeletal muscle should be explored
further.
Curcumin and
tetrahydrocurcumin induce cell death in Ara‐C‐resistant acute
myeloid leukemia
Phytotherapy Research, April 2019
The effective use of curcumin as an
anticancer agent has been demonstrated in clinical trials.
Tetrahydrocurcumin, a major curcumin metabolite, exhibits
pharmacological activities similar to those of curcumin.
Curcumin induces cell death mainly through the apoptosis
pathway, and tetrahydrocurcumin induces cell death mainly via an
autophagy pathway in HL60 cells. The results demonstrated that
curcumin and tetrahydrocurcumin induced cell death by apoptosis
and autophagy, respectively, in Ara‐C‐resistant HL60 cells.
Thus, curcumin and tetrahydrocurcumin have potential
applications in the treatment of acute myeloid leukemia with
Ara‐C resistance.
Curcumin inhibits the
proliferation and invasion of MG-63 cells
OncoTargets and Therapy, April 2019
The aims of this study were to
determine the effect of curcumin on osteosarcoma (OS) cells due
to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the
prognostic value of this pathway in OS. Curcumin-mediated
inhibition of the proliferation and migration of MG-63 cells was
associated with inactivation of JAK/STAT signaling.
Dietary curcumin
enhances intestinal antioxidant capacity
Poultry Science, April 2019
The study investigated the effects
of dietary curcumin supplementation on tissue distribution of
curcumin and its metabolites, intestinal antioxidant capacity,
and expression of detoxification-related genes in ducks. In
conclusion, dietary supplementation with 200 to 800 mg/kg
curcumin enhanced the accumulation of curcumin and its
metabolites in jejunum as well as increasing the antioxidant
capacity and detoxification potential, which play major roles in
the protection of duck intestines against damage.
Histopathological and
biochemical studies on the effect of curcumin and taurine
against bisphenol A toxicity
Environmental Science and Pollution
Research, April 2019
Bisphenol A (BPA) is a chemical
found in environmental xenoestrogen. In the present study, olive
oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus
BPA were exposed to rats for 4 weeks via gavage. Content of
malondialdehyde and activities of antioxidant enzymes (GPx, GST,
SOD, CAT) and also histopathological and cytopathological
changes of heart were studied. No significant changes in all
studied parameters were seen between control, olive oil,
curcumin, and taurine-treated groups. However, there were
significant differences in levels of malondialdehyde and
activities of antioxidant enzymes in BPA-exposed rats and some
histo/cytopathological changes determined. In curcumin plus
BPA-exposed and taurine plus BPA-exposed groups, we measured the
preventive effects on some parameters but not exactly. As a
result, curcumin and taurine significantly minimized BPA-induced
cardiotoxicity in rats.
Protective Effects of Curcumin Against Ischemia-Reperfusion
Injury in the Nervous System Molecular
Neurobiology, March 2019 Curcumin, an active ingredient of
turmeric, can affect all these pathways and exert
neuroprotective activity culminating in the amelioration of I/R
injury in the nervous system. In this review, we discuss the
protective effects of curcumin against I/R injury in the nervous
system and highlight the studies that have linked biological
functions of curcumin and I/R injury improvement.
Top 5 Benefits of Turmeric for your Health The Frisky, March 2019 Curcumin, a recognized
anti-inflammatory, is the main component of turmeric. Curcumin
is said to be as effective as drugstore anti-inflammatories like
ibuprofen and aspirin. Curcumin present in turmeric boosts the
body’s metabolism, reduces stress as an adaptogen, and enhances
weight loss. All these factors combined increase the levels of
good cholesterol in the body, and decrease the effects of bad
cholesterol. It also helps in keeping blood sugar levels in
check by stabilizing the glucose levels in the body. Curcumin
boosts the production of a protein called BDNF, which is vital
to the health of the brain. High BDNF levels generally result in
better memory and mood.
Curcumin
ameliorated myocardial infarction by inhibition of
cardiotoxicity in the rat model Journal of
Cellular Biochemistry, March 2019 Curcumin is touted as a
polyphenol phytocompound with appropriate cardioprotective
properties. Curcumin was found to reduce oxidative status by
reducing SOD and MDA contents ( P < 0.05). Gross and microscopic
examinations revealed that the decrease of infarct area,
inflammation response and collagen deposition in rats given ISO
plus curcumin ( P < 0.05). We noted the superior effect of
curcumin to reduce the number of apoptotic cardiomyocytes after
9 days. Data point the cardioprotective effect of curcumin to
diminish the complication of infarction by the reduction of cell
necrosis and apoptosis in a rat model of experimental
infarction.
How to Stop Suffering from Chemo Brain Care2, March 2019 The yellow-colored compound found in the
curry ingredient turmeric, known as curcumin, offers more than
delicious taste. It is a well-established brain-healer and
memory booster. In a study published in the Journal of
Psychopharmacology researchers found that in just one hour after
taking curcumin supplements, study participants showed
significant performance improvement on memory and attention
tasks compared to the placebo group. Ideally choose a
standardized extract of curcumin. I usually recommend 400 mg of
curcumin three times daily for people suffering from brain
disorders.
Curcumin reduces development of seizurelike events Journal of Cellular Biochemistry, March 2019 The percentage
of recorded CA1 neurons displaying SLEs was lower in
curcumin‐treated slice cultures compared to vehicle‐treated
slices (25.8% vs 72.5%), whereas rapamycin did not reduce SLE
occurrence significantly (52%). Western blot for
phosphorylated‐S6 (pS6) and phosphorylated S6K confirmed that
rapamycin inhibited the mTOR pathway, whereas curcumin only
lowered pS6 expression at one phosphorylation site. Real‐time
quantitative polymerase chain reaction results indicated a trend
toward lower expression of inflammatory markers IL‐1β and IL‐6
and transforming growth factor β after 3 weeks of treatment with
rapamycin and curcumin compared to vehicle. Our results show
that curcumin suppresses SLEs in the combined
hippocampal‐entorhinal cortex slice culture model and suggest
that its antiepileptogenic effects should be further
investigated in experimental models of TLE.
Which herbs help reduce inflammation? Granite Gazette, March 2019 Turmeric typically comes in the
form of a yellow powder from the root of the turmeric plant. It
contains a chemical called curcumin, which may have
anti-inflammatory properties. Several have shown that turmeric
can help reduce inflammation and discomfort in people with . It
works by limiting the production of molecules called cytokines,
which cause inflammation. Researchers continue to how curcumin
affects inflammation in a range of other conditions, such as
inflammatory bowel disease. Curcumin has the evidence base for
its anti-inflammatory effects compared with other herbal
remedies.
Effects of curcumin on hypoxia-inducible factor Pharmacological Research Journal, March 2019 A growing body
of evidence indicates that curcumin, a natural bioactive
compound of turmeric root, significantly targets both HIF-1
subunits, but is more potent against HIF-1α. In this review, we
have summarized the knowledge about the pharmacological effects
of curcumin on HIF-1 and the related molecular mechanisms that
may be effective candidates for the development of
multi-targeted therapy for several human diseases.
Foods to unclog arteries Femina, March 2019 While the anti-cancer benefits of turmeric have been
well-documented, the key ingredient curcumin is also beneficial
to heart health. This is primarily because of its
anti-inflammatory benefits, which directly impacts arterial
health, reducing the damage to arterial walls. Vitamin B6 can
control damage caused to blood vessels.
Turmeric: A Secret Weapon to Lose Weight & Keep It Off Dr. Cesar Lara, March 2019 Curcumin appears to modulate
several cellular pathways that contribute to this ongoing,
damaging process. Indeed, curcumin's anti-obesity effects may be
in part due to its inflammation-reducing properties. One
additional relevant mechanism of action not discussed in this
study is curcumin's capacity to cause programmed cell death in
white fat cells. This may contribute to decreasing the overall
ability of the body to store unhealthy fat. Curcumin's Health
Benefits Given the research above and the plethora of studies on
distinct health conditions, it would be unethical not to use
curcumin. Its safety profile is documented, and it has been
time-tested for thousands of years in a wide range of cultures.
In fact, curcumin has shown to be at least as effective for
depression(8) as the antidepressant Prozac and is capable of
preventing the progression of prediabetes to diabetes. It is
also known to strengthen and improve your digestion(9) and
support healthy liver function. Which Type of Curcumin (Turmeric
Extract) is Best? When cooking, choose a pure turmeric powder
rather than a curry powder. The curry powder may contain very
little curcumin when compared to turmeric. You can also take
curcumin in supplement form, which is a more convenient method
to achieve the dosage needed for the health benefits discussed
above.
Protective effects of curcumin on radioiodine‐induced salivary
gland dysfunction in mice Journal of Tissue
Engineering and Regenerative Medicine, March 2019 Curcumin
and RI + amifostine groups showed evidence of tissue remodeling,
with a greater number of salivary epithelial cells
(AQP‐5‐positive), SG ductal cells (CK18‐positive), endothelial
cells (CD31‐positive), and myoepithelial cells (α‐SMA‐positive).
RI + curcumin and RI + amifostine groups alleviated RI‐induced
cell death, demonstrating anti‐apoptotic effect, compared to the
RI group. Both SOD activity and the protein expression levels of
SOD2 were higher in the RI + curcumin and RI + amifostine groups
than in the RI group. Our results demonstrate that curcumin
ameliorates RI‐induced SG dysfunction in mice.
Top 5 Health Benefits Of Turmeric And Its Compounds You Need To
Know NB Post Gazette, March 2019 Turmeric has anti-inflammatory properties because of the
compound Curcumin. Moreover, it helps in cutting out all the
bacterial infection that has covered the wound. Curcumin can
effectively cure and improve endothelium. Moreover, oxidation
and inflammation is a major partner of heart diseases. As
mentioned earlier, this spice has compounds which have
anti-inflammatory and antioxidative properties.
'Golden Elixir" made from turmeric Press
Republican, March 2019 Turmeric and especially its most
active compound curcumin have many scientifically-proven health
benefits, such as the potential to prevent heart disease,
Alzheimer’s and cancer, according to a July 13, 2018 article on
www.healthline.com It’s a potent anti-inflammatory and
antioxidant and may also help improve symptoms of depression and
arthritis.
Anti-Inflammatory Herbs Care2, March 2019 If you’re thinking that turmeric seems to be good for just about
everything, you’d be right. That’s because the curry ingredient
contains a potent anti-inflammatory known as curcumin. In a
study published in the Journal of Biological Chemistry
researchers found that curcumin improved the healing of
tendonitis, which involves inflammation of the tendons that help
maintain our body’s structural integrity.
Advantages of Curcumin Most Inside, March
2019 Curcumin is a naturally occurring antioxidant abundantly
found in the popular spice turmeric that has been used since
ages in cooking and Ayurvedic medicines for its incredible
health benefits. Turmeric holds a pious place in Ayurvedic
medicine and is applied on cuts and burns due to its anti-septic
properties. Turmeric milk is extensively consumed in India as
turmeric is studied to cure gastrointestinal discomfort,
respiratory issues and helps in treating various bodily
disorders. The Indian food culture places peculiar importance
for spices and it is mainly used for making curry dishes as it
renders distinct colour, flavour and nutrition to the food.
Being such a valued spice on the health front, people across the
world now understand the health benefits of Curcumin. Various
medical researchers worldwide have investigated on how consuming
turmeric or curcumin supplements can alleviate various health
issues.
Know your mesonutrients Times of India,
March 2019 The world has recognised the medicinal use of
curcumin and now curcumin milk, also known as turmeric latte,
and it is part of café menus internationally. Curcumin is the
active ingredient in turmeric, and when you look at all the
research, it’s curcumin that delivers the anti-inflammatory and
anti-ageing benefits that the super-spice is famed for. So, up
your curcumin quotient.
Ayurvedic Herbs May Help Slow Down Ageing NDTV, March 2019 Turmeric, or haldi, is one kitchen
ingredient that is widely used in a number of dishes across the
world. Curcumin, an essential compound found in turmeric, is
shown to possess powerful anti-ageing effect. According to the
book, 'Healing Foods' by DK Publishing House, "Curcumin reduces
the build-up of the protein amyloid-b in the brain. Amyloid-b
causes oxidative (free radical) damage and inflammation in the
brain and is one of the main causes of Alzheimer's disease.
Antioxidants in turmeric help to fight this free-radical
damage."
Best supplements for arthritis: The Ayurveda plant supplement
proven to support joints Express, March
2019 Curcumin’s effect on reducing inflammation means it can
also help protect your joints from wear and tear. “This includes
easing symptoms of arthritis like joint movement and stiffness,
according to a 2016 study in Journal of Medicinal Food.”
Best supplements for diabetes type 2 to avoid high blood sugar
symptoms Express, March 2019 Turmeric
could help to lower your risk of high blood sugar, according to
The Diabetes Council. Its active ingredient, curcumin, could
help patients to improve their insulin sensitivity, it said.
Diabetes patients that take turmeric supplements could
significantly lower their blood sugar levels and insulin
resistance, it added. “Curcumin is the yellowish/orangish powder
which gives turmeric its beautiful colour in curry powder,” said
The Diabetes Council. “It is widely used in many regions of the
world for its pain-relieving features, improving digestion and
liver functions. “A study discovered that curcumin decreases
blood [sugar] levels and improved the sensitivity of insulin by
reducing serum free fatty acids and increasing fatty acid
oxidation.“Supplements containing curcumin significantly
decreased fasting blood levels and insulin resistance in type 2
patients. “Use of curcumin also led to a significant decrease in
serum, triglyceride fats, and an increase in lipoprotein
lipase.”
Crusade against cancer: New treatment and nutrients you can rely
on The Heath Site, March 2019 Turmeric:
It is rich in curcumin, a compound that is responsible for its
yellow pigment. Being a powerful antioxidant, curcumin can
potentially prevent chronic inflammation, responsible for some
cancers. Just like ursolic acid, it also inhibits cancer cell
growth. Curcumin is helpful in cancers pertaining to breast,
ovary, uterus, kidney, bladder, brain, blood, colon and rectum,
liver, pancreas, lung, etc. Add curcumin to your meals by
sprinkling turmeric in your favourite dishes.
In vitro
effect of curcumin on Schistosoma species viability Experimental Parasitology, March 2019 Curcumin (CUR), the
major phenolic compound present in rhizome of turmeric (Curcuma
longa L.), has been traditionally used against various diseases
including parasitic infections. CUR was found to affect the
antigenicity of surface membrane molecules of S. haematobium,
but not S. mansoni. Of importance, CUR significantly (P < 0.05
to < 0.0001) affected S. mansoni eggs hatchability and
viability, a ground for its use in chemotherapy of
schistosomiasis mansoni and japonicum because of its increased
bioavailability in the gastrointestinal tract. The data together
emphasize that CUR is a promising potential schistosomicidal
drug.
20
Health benefits of Turmeric InfoLoving.com
February 2019 Turmeric (Curcuma longa) is the root of a plant
that belongs to the same family as ginger. It is even less known
in western cuisine, except as part of the spice mixture curry.
The specific orange-yellow color is what gives curry powder its
yellow color. There are 3 different yellow pigments
(curcuminoids) in the turmeric root and these are also the
substances that give turmeric its beneficial effects. These
curcuminoids all work anti-oxidatively, anti-inflammatory, and
are toxic to tumor cells. The most bioactive and tested
substance of the three is curcumin that also has antiviral and
antifungal properties. About 3% (in weight) of the turmeric root
is curcumin. Health benefits of Turmeric is unlimited according
to its uses. Most studies on the curative effect of turmeric are
done with the extracted curcumin and high doses of 500 mg to 4
grams per day. To get that kind of quantities you have to use
supplements with curcumin. This is especially true for people
who are really sick or suffer from a specific condition.
Curcumin Antidiabetic and Anticancer Potential Anticancer Research, February 2019 Curcumin and
cinnamaldehyde have been previously reported to have
antidiabetic and anticancer potentials. Curcumin and
cinnamaldehyde decreased the activity of PTP1B, and had
inhibitory effects on the viability of MCF-7 cancer cells.
Curcumin had a significantly higher inhibitory effect than
cinnamaldehyde. Conclusion: Curcumin can be considered a
potential agent for the treatment of type-2 diabetes or cancer.
Does turmeric/curcumin supplementation improve nonalcoholic
fatty liver disease? Phytotherapy Research,
February 2019 We performed a meta‐analysis to evaluate the
efficacy of turmeric/curcumin supplementation on serum alanine
aminotransferase (ALT) and aspartate aminotransferase (AST) in
patients with nonalcoholic fatty liver disease (NAFLD). We
searched PubMed, Scopus, Cochrane Library, ISI Web of Science,
and Google Scholar up to November 20, 2018. Results from pooled
analysis revealed that turmeric/curcumin supplementation reduced
ALT (MD: −7.31 UL/L, 95% CI [−13.16, −1.47], p = 0.014) and AST
(MD: −4.68 UL/L, 95% CI [−8.75 −0.60], p = 0.026). When RCTs
stratified on the basis of their treatment duration, the
significant reduction in serum concentrations of ALT and AST was
observed only in studies lasting less than 12 weeks. This review
suggests that turmeric/curcumin might have a favorable effect on
serum concentrations of ALT and AST in patients with NAFLD.
Amazing Health Benefits of Curcumin/Turmeric Supplements JottedLines.com, February 2019 Turmeric is biologically
closely related to Ginger and is a very common ingredient in
South Asian cuisines. Also called the Golden Spice, this
lustrous golden-yellow spice is also treated as a herb whose
properties are associated with purity and auspiciousness. One of
the important compounds in Turmeric is Curcumin, which is
credited for giving the spice its distinct color. Recent
research has also revealed a gamut of health benefits that
Curcumin offers. We all know that aging and debility are caused
in part due to oxidative damage incurred by our cells. Free
radicals that are ingested via the food we eat react with
proteins, fatty acids & can even damage our DNA. Curcumin
capsules essentially negate the action of free radicals on top
of augmenting the body’s own antioxidant enzymes. This way,
Curcumin/Turmeric deals a double blow to free radicals. Curcumin
supplements are found to instigate the production of neurons in
adults. Conventional wisdom had it that our brain does not
create any more neurons once we are past childhood. But recent
theories pertaining to neuroplasticity and neuroadaptibility
have shown how our brains have amazing abilities to regenerate
and restructure in constructive ways to enhance the survival
potential of brain-injured patients. But this process does not
happen in a vacuum. Under a regimen of certain nootropics like
Curcumin/Turmeric, BDNF levels were observed to increase
significantly. BDNF is in essence a growth hormone that acts in
the central nervous system. Since BDNF is found to be subdued in
people suffering from various psychiatric and neurological
disorders, an increase in BDNF is expected to improve these
conditions.
A
randomized, double-blind, placebo-controlled trial to evaluate
the role of curcumin in prostate cancer patients Prostate, February 2019 The anti-cancer activities of
curcumin are well-documented from preclinical studies using
prostate cancer models. Our objective was to evaluate the
anti-cancer activity of oral curcumin in patients with prostate
cancer. The proportion of patients with PSA progression during
the active curcumin treatment period (6 months) was
significantly lower in the curcumin group than the placebo group
(10.3% vs 30.2%, P = 0.0259). PSA elevation was suppressed with
curcumin intake during the curcumin administration period.
Curcumin at this dose was well tolerated and safe. Turmeric is
an excellent aid for digestion because it already contains many
of the minerals, vitamins, antioxidants, fiber, and
anti-inflammatory compounds you need to "help acid production,
muscle movement, and nutrient absorption to keep things moving
like they should." The curcumin in turmeric: • helps the muscle
walls of the intestines relax • balances gut flora in the colon
• increases production of stomach mucous • eliminates
cholesterol • prevents gas and bloating during digestion •
relieves IBS symptoms. Taking curcumin can actually boost BDNF
levels back up over time and even reverse the damage. Higher
serotonin and dopamine may also be side effects of taking
curcumin. A study actually found that people that took curcumin
in addition to Prozac fared better than those just on Prozac or
just taking curcumin for depression.
Curcumin: Can it slow cancer growth? Mayo
Clinic, February 2019 Curcumin, a substance found in the
spice turmeric, has long been used in Asian medicine to treat a
variety of maladies. Now some research suggests that curcumin
may help prevent or treat cancer. Curcumin is thought to have
antioxidant properties, which means it may decrease swelling and
inflammation. It's being explored as a cancer treatment in part
because inflammation appears to play a role in cancer.
Laboratory and animal research suggests that curcumin may
prevent cancer, slow the spread of cancer, make chemotherapy
more effective and protect healthy cells from damage by
radiation therapy. Curcumin is being studied for use in many
types of cancer.
Curcumin a known anti inflammatory and antioxidant agent International Journal of Molecular Biology: Open Access,
February 2019 Curcumin is an active yellow color curcuminoid
compound which is a naturally occurring plant pigment that is
mostly found in turmeric and is native to Southeast Asia and
India.1 It has an earthy odor and somewhat bitter taste and is
mostly used in culinary.2 It is reported that pure turmeric
residues contains about 3 percent of curcumin by weight.3
However curcumin is also available in the form of turmeric
extract supplements which contains higher concentration of
curcumin.4 It exhibits strong anti-inflammatory and antioxidant
properties.5 In addition to that it is an excellent healing
agent.6Health benefits of curcuminSome health benefits of
curcumin are as follows:Relieves inflammationCurcumin is well
known for its anti-inflammatory property that reduces chronic
inflammation occurring in a number of medical conditions such as
arthritis, bowel disease, heart disease, cancer, and diabetes
etc.7 It has the ability to effectively block the function of
those enzymes that contributes in inflammatory pathway.8Supports
skin healthAntioxidant property of curcuminhelps in neutralizing
free radicals that causes cell damage.9 In addition to that it
accelerates healing of the wounds and collagen deposition in the
skin.10 Curcumin is found to effective in treating psoriasis,
dermatitis and scabies.11Lowers high blood sugarDiabetes
associated symptoms such as impaired wound healing, increased
thirst, vision loss, nerve damage, weight loss etc could be
overcome by the use of curcumin which increases insulin
secretion to reduce high glucose level in the
blood.12,13Treatment of cancersCurcumin has an anti-cancerous
effect on the growth of cancerous and tumour cells.14 It
inhibits the function of cancer inducing growth factors and
enzymes and blocks the signaling pathway hat is involved in the
development of cancer in organs like breast, colon, pancreas and
lungs.15,16Treatment of mental illnessesCurcumin aids in the
treatment of depression and anxiety by reducing its associated
symptoms.17 It increase the levels of omega-3 fatty acid that
promotes the development of brain.18Prevents blood
clottingCurcumin reduces platelet aggregation in the blood by
inhibiting the formation of thromboxanes that causes clot
formation in conditions like pulmonary embolism, stroke and deep
vein thrombosis.19Reduces joint painRelieve rheumatoid arthritis
related symptoms like stiffness, pain, swelling etc.20Regulates
high cholesterol levelCurcumin boost cardiac health by lowering
high cholesterol levels in blood.21Improves
detoxificationCurcumin stimulates detoxification in order to
protect the liver from diseases, allowing removal of toxins and
cancer causing substances from the body.22Enhance brain
functionCurcumin maintains cognitive function and prevent the
risks of neurodegenerative diseases such as Parkinson’s and
Alzheimer’s.23 It elevates the amount of brain derived neuro
tropic factors which is involved in enhancing brain function,
improving memory and reduces oxidative damage.24,2
Nootropic Supplements to Boost Memory & Brain Function SD Entertainer, February 2019 Found
in turmeric, curcumin has been shown to increase mental focus
while reducing brain fog. The curcuminoids found in curcumin are
effective at fighting oxidative stress caused by free radicals,
boosting neural connections in the process.
Curcumin and Cancer Cancer Therapy Advisor,
February 2019 Curcumin inhibits
cell proliferation and induces cell cycle arrest, apoptosis, and
senescence — through various mechanisms, across multiple
different types of cancer cell lines. Curcumin has been shown to
decrease the expression of multiple different enzymes,
transcription factors, inflammatory cytokines, growth factors,
and other cell-signaling components that are important for
cancer growth and progression. Curcumin downregulates the
expression of the transcription factor NF-κB, which is commonly
highly expressed by cancer cells and is known to promote the
development of cancer, metastasis, and tumor growth.2 In
addition, curcumin arrests the cell cycle at the G1/S or G2/M
phases by inhibition of different cyclins. Curcumin also induces
apoptosis through caspase-dependent pathways, and decreases the
expression of antiapoptotic proteins. Curcumin has been
evaluat ed in animal models of different cancer types.3 These
studies have generally shown that curcumin has antiproliferative
effects. For example, a mouse model of colorectal cancer (CRC)
that was treated by intraperitoneal injection of curcumin or
vehicle control demonstrated that curcumin prolonged life and
inhibited tumor growth.4 These data also suggest that curcumin
upregulated the miRNA miR-130a, which decreased the
Wnt/β-catenin pathway and led to prolonged survival. Studies in
animal models of breast cancer demonstrated that curcumin also
downregulates NF-κB, reduces metastasis, and inhibits angiogenic
signaling resulting in decreased microvessel formation.5 Animal
studies of pancreatic cancer have also demonstrated that
curcumin inhibits tumor growth, suppresses proliferation, and
reduces angiogenesis.
A powerful antioxidant: Curcumin protects your heart from damage
caused by diabetes and smoking Plant
Medicine, February 2019 To protect your heart from damage
caused by diabetes and smoking, take curcumin supplements. A
study published in the African Journal of Traditional,
Complementary and Alternative Medicines found that curcumin
protects the heart from the combined oxidative stress induced by
diabetes and nicotine. In the study, researchers from King Saud
University in Saudi Arabia assessed the ability of curcumin to
ameliorate the combined oxidative stress induced by diabetes and
smoking which can cause diabetic cardiomyopathy. Diabetes and
cigarette smoking, which both cause oxidative stress, are
primary factors that cause cardiovascular diseases. Curcumin is
known to have protective effects against hyperglycemia-induced
oxidative stress. When curcumin was administered, it inhibited
the diabetic and nicotine-induced oxidative stress, which was
seen by the normalization of the plasma cardiac marker troponin
I and CK-MB. Based on these findings, the researchers concluded
that curcumin has a protective effect on heart tissues against
the combined oxidative stress induced by diabetes and nicotine.
Curcumin can also keep the heart healthy and protect it from
diseases by improving the function of the endothelium or blood
vessel lining. According to Healthline, this improvement in the
blood vessel lining can significantly reduce the risk of
endothelial dysfunction, which is a primary risk factor of heart
disease. It prevents the endothelium from regulating blood
pressure and blood clotting properly. Many other studies have
confirmed this beneficial effect of curcumin. One study even
suggested that curcumin is as effective as exercise in this
respect. Another study suggested daily supplementation of
curcumin can improve heart health by improving cholesterol
levels and reducing inflammation. This, in turn, may prevent the
onset of atherosclerosis, which is a disease in which plaque
builds up inside the arteries.
Spice may protect against breast cancer MiceTimes, February 2019 Studies have shown that curcumin
(the main chemical component of turmeric) has a number of
valuable properties. In particular, curcumin can play a
supportive role in the prevention of Alzheimer’s disease – it
starts the process of protein production, which is struggling
with brain damage by free radicals. In addition, it was revealed
that curcumin can help in the treatment of skin cancer. The
study, conducted by researchers from the cancer Center to them.
Andersen at Texas a & m University (USA), curcumin was
administered in the affected melanoma cell line, stimulated the
destruction of malignant cells in tumors. There is also reason
to believe that curcumin prevents the development of breast
cancer. Expressive about this show in particular, experiments on
mice conducted in the same the University of Texas. Now
scientists are actively exploring other potential therapeutic
properties of curcumin, in particular, for the treatment of
multiple myeloma and pancreatic cancer, and the prevention of
oral cancer.
Which herbs help reduce inflammation? Medical News Today, February 2019 Turmeric typically comes in the form of a yellow powder from the
root of the turmeric plant. It contains a chemical called
curcumin, which may have anti-inflammatory properties. Several
studies have shown that turmeric can help reduce inflammation
and discomfort in people with arthritis. It works by limiting
the production of molecules called cytokines, which cause
inflammation. Researchers continue to investigate how curcumin
affects inflammation in a range of other conditions, such as
inflammatory bowel disease. Curcumin has the most substantial
evidence base for its anti-inflammatory effects compared with
other herbal remedies.
Turmeric helps prevent diabetes Orissa
Post, February 2019 Curcumin which is a component of turmeric
helps prevent fatty deposits in blood vessels and development of
fat tissues. So, adding turmeric in diet helps one maintain a
healthy weight. Turmeric also promotes healthy bones by
decreasing loss of bone minerals in the body.
Curcumin shows heart health benefits by ‘multiple mechanisms’ Nutra Ingredients, February 2019 In addition to the total and
LDL cholesterol reductions, the researchers noted that HDL
cholesterol was unaffected by curcumin addition to the diet.
“These results support our hypothesis and indicate that curcumin
may prevent the progression of atherosclerosis by reducing lipid
accumulation. It appears that curcumin may prevent the
progression of atherosclerosis by reducing lipid accumulation on
the aortic endothelium.
Can curcumin improve exercise performance in those with heart
failure? Medical News Bulletin, February
2019 Curcumin administration restored muscle force and
prevented rapid fatigue. Finally, the authors demonstrated that
the positive effects of curcumin on CHF mice were attributed to
improved Nrf2 signaling and not due to improved cardiac
function. In conclusion, the data reaffirmed the authors’
hypothesis that impaired Nrf2 signaling in skeletal muscle of
CHF mice contributes to exercise intolerance. More specifically,
impaired Nrf2 signaling prevents the skeletal muscle from
defending itself against CHF-associated oxidative stress, which
likely affects skeletal muscle performance and reduces exercise
capacity. These findings were further strengthened by the notion
that curcumin, a Nrf2 signaling promoter, improved exercise
capacity in mice with chronic failure without noticeable
improvements in heart function and blood flow. Collectively, the
authors found that targeting the Nrf2 signaling pathway may
improve exercise capacity and overall quality of life in
patients with chronic heart failure.
Can ginger, turmeric and lemon juice reduce blood sugar? Legit.ng February 2019 The component of the popular curry
spice, turmeric, also can help to lower the high index to normal
blood sugar level. Curcumin, polyphenol and antioxidants play a
vital role in this process. They reduce the amount of glucose in
blood by slowing down its formation the liver.
Diabetes mellitus: Blood sugar-lowering ginger + other root
vegetables for type 2 diabetes The Health
Site, February 2019 Turmeric root: Curcumin, found in
turmeric exerts helps moderate insulin levels and enhance the
efficacy of anti-diabetic drugs. Antioxidant-rich turmeric
fights free radicals and reduces insulin resistance in the body.
A study conducted by Department of Pediatrics, Louisiana State
University Health Sciences Center revealed that curcumin present
in turmeric prevents protein glycosylation (where the protein
molecule is altered) and lipid peroxidation (oxidative
degradation of lipids), thereby increasing the person’s
sensitivity to lower blood sugar levels.
Three lesser known facts of turmeric Baltimore Post Examiner, February 2019 Turmeric is an
anti-inflammatory- The active ingredient in turmeric is
something call curcumin, which is known for fighting
inflammation and being full of antioxidants. The curcumin in
turmeric fights inflammation at the molecular level, blocking a
molecule called NF-kB, which is linked to many different
inflammatory diseases like arthritis and IBD. 2. It helps with
depression - Taking curcumin can actually boost BDNF levels back
up over time and even reverse the damage. Higher serotonin and
dopamine may also be side effects of taking curcumin. 3.
Turmeric helps with digestion - Turmeric is an excellent aid for
digestion because it already contains many of the minerals,
vitamins, antioxidants, fiber, and anti-inflammatory compounds
you need to "help acid production. The curcumin in turmeric has
many benefits which includes the muscle walls of the intestines
relax, balances gut flora in the colon increases production of
stomach mucous, eliminates cholesterol, prevents gas and
bloating during digestion and relieves IBS symptoms.
Foods that can boost your brain power Savannah Now, February 2019 This spice, commonly found in
Indian food, turns out to have an almost endless list of health
benefits. It has been tied to improving gastrointestinal issues,
and reducing the chances of getting heart disease, cancer and
Alzheimer’s. Turmeric has also been found to reduce
inflammation, primarily due to a compound in it called curcumin.
Diseases like depression and Alzheimer’s have been linked to
lower levels of brain-derived neurotrophic factor (BDNF), a type
of growth hormone that helps with the formation of new neural
connections in the brain. Turns out curcumin has been found to
increase brain levels of BDNF. So by adding turmeric to soups
and other dishes, you’ll be delaying or even reversing the
effects of declining brain function.
Inhibition mechanism of cathepsin B by curcumin molecule: a DFT
study Theoretical Chemistry, February 2019 One of the natural compounds named curcumin has a
well-documented history of medicine in India, which is currently
in clinical trials for the treatment of various cancers.
However, the inhibition mechanism of the curcumin molecule is
not yet clear. In this present study, the inhibition of
cathepsin B by the curcumin has been studied by quantum chemical
methods using DFT method at M062X/6-31 + g(d,p)//B3LYP/6-31g(d)
level of theory to obtain a complete picture of possible
reaction paths. Based on the obtained results, the Cys29 can
undergo nucleophilic attack at any one of the four reactive
sites of the curcumin. The low activation energy 1.43 kcal/mol
along with low negative reaction energy − 6.82 kcal/mol suggests
that attack of Cys29 at C63 atom is the most feasible reaction
path. These results suggest that curcumin can be used to develop
less toxic cathepsin B inhibitors for the treatment of cancer
disease.
Science confirms turmeric as effective as 14 drugs Health Nut News, February 2019 If ever there were an herb
that puts existential fear into the bottom line of
pharmaceutical companies, its turmeric.
Are mesonutrients the new macronutrients? Femina, February 2019 Mesonutrients are the active compounds
that are present in each food, which are responsible for good
health. Typically found in foods that are classified as
superfoods, it is not just important to eat these foods – it is
important to eat them the right way, so as to obtain the maximum
benefits of the mesonutrients. One of the key mesonutrients is a
staple in the Indian kitchen – turmeric. It has over 200 active
compounds, and the key compound to watch out for is curcumin,
which has anti-cancer and anti-inflammatory benefits.
The Unsung Benefits of Turmeric... and Why You Should Use It Women.com, February 2019 The active ingredient in turmeric is
something call curcumin, which is known for fighting
inflammation and being full of antioxidants. The curcumin in
turmeric fights inflammation at the molecular level, blocking a
molecule called NF-kB, which is linked to many different
inflammatory diseases like arthritis and IBD. Studies have found
turmeric to be just as effective as medication but without the
side effects that many anti-inflammatory medications have. In
fact, one study found of rheumatoid arthritis found 500 mg a day
of curcumin was more beneficial than diclofenac, an
anti-inflammatory drug.
Impact of
curcumin on energy metabolism in HIV infection: A case study. Phytother Res, February 2019 Curcumin is a natural bioactive
compound, which interacts with molecular targets and holds
important metabolic properties. Oral curcumin supplementation
can positively modulate the energy metabolism of people living
with HIV/AIDS using the ART.
Efficacy of curcumin for management of oral submucous fibrosis:
a systematic review of randomized clinical trials Science Direct, February 2019 Six clinical trials comprising
298 patients were included. All studies found curcumin to be
effective in the management of OSF. Three studies found
significantly higher improvement in burning sensation in the
curcumin group compared to controls, whereas three studies found
comparable results. With regards to clinical signs, two studies
showed better improvement in mouth opening in the curcumin
group; three studies reported no differences in effectiveness;
and only one study found curcumin to be inferior to conventional
therapy. The available evidence remains inconclusive but
suggests that curcumin is a promising effective treatment option
for the management of patients with OSF. Further well-designed
clinical trials with large sample sizes and adequate follow-up
periods are highly warranted.
Curcumin improves the effect of a reduced insulin dose on
glycemic control and oxidative stress in streptozotocin‐diabetic
rats Phytotherapy Research, February 2019 Isolated treatments using curcumin or insulin in a reduced dose
(1 U/day) decreased glycemia, dyslipidemia, and biomarkers of
liver and kidney damage and increased the activity of hepatic
antioxidants (superoxide dismutase and glutathione peroxidase),
however, only to a lesser extent than 4‐U/day insulin, without
improvements in catalase activity or plasma lipid peroxidation.
Decreases in glycemia, dyslipidemia, and tissue damage markers
were more evident in the curcumin + 1‐U/day insulin treatment
than those seen in isolated treatments. The activity of hepatic
antioxidants, including catalase, was further increased, and
biomarkers of oxidative damage were decreased. Curcumin with a
reduced insulin dose appears to be a promising strategy for
combating the complications associated with diabetes and
oxidative stress.
Curcumin Suppresses Hepatic Stellate Cell-Induced
Hepatocarcinoma Angiogenesis Oxidative
Medicine and Cellular Longevity, February 2019 Curcumin could
significantly suppress the HSC-induced effects in HCC and could
abrogate ROS and HIF-1α expression in HCC. HIF-1α or connective
tissue growth factor (CTGF) knockdown could abolish the
aforementioned curcumin affection. Moreover, CTGF is a
downstream gene of HIF-1α. In addition, nuclear factor
E2-related factor 2 (Nrf2) and glutathione (GSH) are involved in
curcumin protection of HCC. These data indicate that curcumin
may induce ROS scavenging by upregulating Nrf2 and GSH, thus
inhibiting HIF-1α stabilization to suppress CTGF expression to
exhibit its protection on HCC. Curcumin has a promising
therapeutic effect on HCC. CTGF is responsible for
curcumin-induced protection in HCC.
Curcumin ameliorates glyoxylate-induced calcium oxalate
deposition and renal injuries in mice Sciene Direct, February 2019 Curcumin, the predominant active
component of turmeric, has been shown to have pleiotropic
biological and pharmacological properties, such as antioxidant,
anti-inflammatory and antifibrotic effects. Curcumin could
significantly alleviate CaOx crystal deposition in the mouse
kidney and the concurrent renal tissue injury. The underlying
mechanism involved the combination of antioxidant,
anti-apoptotic, inhibiting autophagy, anti-inflammatory, and
antifibrotic activity and the ability to decrease expression of
OPN and CD44 through the Nrf2 signaling pathway. The pleiotropic
antilithic properties, combined with the minimal side effects,
make curcumin a good potential choice to prevent and treat new
or recurrent nephrolithiasis.
Curcumin supplementation reduces insulin resistance and blood
lipids in individuals with high risk of type 2 diabetes Lipids in Health and Disease, February 2019 nsulin
sensitivity was significantly improved in the CC supplemented
group (32.7 ± 10.3%) compared to PL (P = 0.009). FO and
CC-Curcumin tended to improve insulin sensitivity by 14.6 ± 8.5%
and 8.8 ± 7.7% respectively, but the difference did not reach
significance. Triglyceride levels were further increased in the
PL (26.9 ± 7.4%), however, CC and CC-Curcumin supplementation
reduced the triglycerides, Curcumin resulted in the greatest
reduction in triglycerides (− 16.4 ± 4.5%, P < 0.001).
Conclusion Reduction in insulin resistance and triglycerides by
curcumin and LCn-3PUFA appears to be attractive strategies for
lowering the risk of developing T2D
Curcumin attenuates adhesion molecules and matrix
metalloproteinase expression in hypercholesterolemic rabbits Science Direct, February 2019 Curcumin, the yellow substance
found in turmeric, possesses antioxidant, anti-inflammation,
anticancer, and lipid-lowering properties. Curcumin reduced the
levels of total cholesterol, triglyceride, low-density
lipoprotein cholesterol, and oxidized low-density lipoprotein
cholesterol in serum by 30.7%, 41.3%, 30.4%, and 66.9% (all P <
.05), respectively, but did not affect high-density lipoprotein
cholesterol levels. In addition, curcumin attenuated HCD-induced
CD36 expression, circulating inflammatory cytokines, and soluble
adhesive molecule levels. Curcumin reduced the mRNA and protein
expression of intracellular adhesion molecule-1, vascular cell
adhesion molecule-1, P-selectin, and monocyte chemotactic
protein-1, and it inhibited HCD-induced up-regulation of MMP-1,
MMP-2, and MMP-9. Our results demonstrate that curcumin exerts
an antiatherosclerotic effect, which is mediated by multiple
mechanisms that include lowering serum lipids and oxidized
low-density lipoprotein, thus modulating the proinflammatory
cytokine levels and altering adhesion molecules and MMP gene
expression.
4 Health Benefits Of Turmeric
Medical Daily, January 2019
"Turmeric has natural
anti-inflammatory compounds called curcuminoids, and these
curcuminoids have been associated with a positive effect on
various diseases," said Anya Guy, a Mayo Clinic dietitian.
Inflammation, as you may know, it the cause of several long-term
health conditions. As a result, many studies have examined the
potential of turmeric to ward off heart disease or reduce the
risk of certain cancers. It is said that curcumin can help in
reducing inflammation in pancreatic, fat and muscle cells. While
most research on the link has involved rats, there was a
clinical study in 2015 which saw 44 human participants
experiencing a healthy weight loss over the course of two
months. In a review published in 2016, participants from many
trials reported that their osteoarthritis-related pain had
reduced after taking curcumin. "Its efficacy in reducing pain,
physical function, and quality of life among osteoarthritic
patients has been demonstrated in many clinical trials," the
authors wrote.
Effects of oral curcumin ingested before or after eccentric
exercise on markers of muscle damage and inflammation.
Scand J Med Sci Sports, January 2019
We examined the effect of curcumin
(CUR) ingestion before or after exercise on changes in muscle
damage and inflammatory responses after exercise. Increases in
IL-8 were significantly reduced 12 h after exercise when
curcumin was ingested before exercise. In Exp. 2, compared to
the PLA subjects, MVC torque and ROM were higher 3-7 days and
2-7 days after exercise (P<0.05), respectively, whereas muscle
soreness and CK activity were lower 3-6 days and 5-7 days after
exercise (P<0.05), respectively, in curcumin subjects. Curcumin
ingestion before exercise could attenuate acute inflammation,
and after exercise could attenuate muscle damage and facilitate
faster recovery.
6 Things That Happen To Your Body When You Eat
Turmeric Every Day
He althy
Food House, January 2019
Turmeric is a potent
anti-inflammatory, due to the presence of numerous
anti-inflammatory compounds, such as curcumin, one of its most
abundant compounds. After reviewing more than 700 studies, Dr.
James Duke, a well-respected ethnobotanist, found that turmeric
effectively outperformed many pharmaceutical drugs prescribed
for various chronic, debilitative conditions, without causing
any significant side effects. Curcumin eliminates plaque buildup
in the arteries, and thus lowers the risk of atherosclerosis,
which can cause a heart attack or stroke. It also lowers bad
cholesterol known as LDL and prevents the formation of blood
clots. Researchers have shown that curcumin triggers the
production of bile in the gallbladder, and turmeric acts as a
potential safeguard against remission in the case of ulcerative
colitis. Turmeric has excellent anti-inflammatory properties,
and rheumatoid arthritis patients who supplemented curcumin into
their diets found that it led to a “reduction in tenderness” and
a reduction in “disease activity”. Curcumin improves our ability
to learn and process in different environments and prevents the
development of neurodegenerative conditions, such as – dementia
disorders and Alzheimer’s. Scientists have even proven that
turmeric may aid in neuroplasticity, which is the development of
new brain connections. According to Dr.Mercola: Curcumin is
capable of crossing your blood-brain barrier, which is one
factor that has led researchers to investigate its potential as
a neuroprotective agent for neurological disorders such as
Parkinson’s and Alzheimer’s disease. The potent antioxidant and
anti-inflammatory properties of curcumin suggest it may also
promote brain health in general. In the case of Alzheimer’s,
recent animal research14 has discovered another bioactive
ingredient in turmeric, besides curcumin, that adds to its
neuroprotective effects. According to researchers at the
American Cancer Society, curcumin“ interferes with several
important molecular pathways involved in cancer development,
growth, and spread.” Moreover, the US National Library of
Medicine and National Institutes of Health published a study
which showed that curcumin has potent cancer-fighting
properties: “The activity of curcumin reported against leukemia
and lymphoma, gastrointestinal cancers, genitourinary cancers,
breast cancer, ovarian cancer, head and neck squamous cell
carcinoma, lung cancer, melanoma, neurological cancers, and
sarcoma reflects its ability to affect multiple targets. Thus,
an “old-age” disease such as cancer requires an “age-old”
treatment.” “As noted by Dr. William LaValley—one of the leading
natural medicine cancer physicians whom I’ve previously
interviewed on this topic—curcumin is unique in that it appears
to be universally useful for just about every type of cancer.
This is odd, considering the fact that cancer consists of a wide
variety of different molecular pathologies. One reason for this
universal anti-cancer proclivity is curcumin’s ability to affect
multiple molecular targets, via multiple pathways. Once it gets
into a cell, it affects more than 100 different molecular
pathways. And, as explained by Dr. LaValley, whether the
curcumin molecule causes an increase in activity of a particular
molecular target, or decrease/inhibition of activity, studies
repeatedly show that the end result is a potent anti-cancer
activity.”
How to live longer
Express, January 2019
Turmeric is packed with curcumin,
which helps relieve long-term inflammation. Several studies have
shown signs of inflammation are reduced in people who have taken
capsules containing curcumin. Long-term inflammation can lead to
health problems like inflammatory bowel disease, some cancers,
dementia and arthritis. Turmeric may also help brain health, as
curcumin may prevent amyloid-beta plaques forming in the brain -
one of the hallmarks of Alzheimer’s disease - and may also help
break them down. In addition, some lab-based studies have
suggested curcumin may be able to kill cancer cells,
particularly in the breast, bowel, stomach and skin, and prevent
them from growing.
11 Health Benefits of Turmeric and Curcumin
HealthSky, January 2019
Research shows that curcumin binds to
toxic metals and acts as an anti-inflammatory agent. Curcumin is
also a strong antioxidant that captures and neutralizes free
radicals (that are pathogenic particles). This brings all kinds
of health benefits. Research shows that the curcumin in turmeric
has a powerful anti-inflammatory effect. In some cases, it works
better than an anti-inflammatory drug. The antioxidant effect of
curcumin is very strong: animal research even shows that the
antioxidant curcumin has a detoxifying effect in mercury
poisoning. There are strong indications that the substance
curcumin in yellow root has an inhibitory effect on the
development of cancer cells. For example, research in rats has
shown that curcumin can partially neutralize damage to cells in
the liver, kidneys and brain, and thus prevent cancer in these
organs. Research in humans shows that a curcumin supplement
fights the pain better than the drug diclofenac. This is very
beneficial, because the pain-relieving medication can cause
serious side effects, while the natural substance curcumin does
not damage the body. Alzheimer’s is caused by the fact that
certain proteins (such as tau protein) clump in the brain,
causing brain cells to die off. Studies in rats show that
curcumin can prevent tau protein from coagulating. This keeps
the brain healthy. Curcumin plays a major role in preventing and
curing stomach ulcers, and supports a poorly functioning liver.
Animal research shows that curcumin can reduce the risk of liver
damage. Rats that were also given curcumin in their diet were
less likely to suffer from liver disease than rats who did not.
Research in rats shows that curcumin stimulates spatial memory.
The rats given curcumin were significantly better at solving
spatial puzzles than the rats that did not. In a study with 121
people undergoing cardiac surgery, participants were given 4
grams of curcumin or placebo, a few days before they were
operated. The participants who received curcumin were 65% less
likely to have a heart attack in the hospital. A recent article
from 2017 looked at all the research done on turmeric and
depression. This meta-analysis shows that the substance curcumin
is indeed a safe and effective natural means to reduce
depressive feelings. Curcumin can reduce the symptoms of
depression, both on its own and in combination with other herbs.
A very interesting outcome is that curcumin can strengthen the
effect of antidepressants: the drugs for depression work better
if curcumin is taken as a supplement. Turmeric capsules also
contain much more of the active ingredient curcumin than the
spice turmeric itself. In curcuma is about 3% curcumin, while
that in turmeric capsules is 95%.
Curcumin attenuates collagen-induced inflammatory response
through the "gut-brain axis"
J Neuroinflammation, January 2019
Previous studies have demonstrated
that oral administration of curcumin exhibited an anti-arthritic
effect despite its poor bioavailability. The present study aimed
to explore whether the gut-brain axis is involved in the
therapeutic effect of curcumin. Oral administration of curcumin
restored the imbalance between the sympathetic and
parasympathetic tones in CIA rats and increased ChAT activity
and expression of ChAT and VAChT in the gut, brain, and
synovium. Additionally, VGX eliminated the effects of curcumin
on arthritis and ACh biosynthesis and transport.
Electrophysiological data showed that curcumin markedly
increased neuronal excitability of the vagus nerve. Furthermore,
selective α7 nAChR antagonists abolished the effects of curcumin
on CIA. Our results demonstrate that curcumin attenuates CIA
through the "gut-brain axis" by modulating the function of the
cholinergic system. These findings provide a novel approach for
mechanistic studies of anti-arthritic compounds with low oral
absorption and bioavailability.
This Is How Much Turmeric You Need to Reduce
Inflammation
Readers Digest, January 2019
Curcumin—the main active component
which gives turmeric its anti-inflammatory and antioxidant
properties—only makes up 3 percent of dry turmeric, according to
Ali Webster PhD, RD, Associate Director of Nutrition
Communications, International Food Information Council
Foundation. “Turmeric extracts or isolated curcumin found in
dietary supplements are much higher in curcumin, so they’re more
likely to have an impact on inflammation than the dried spice,”
she says. So a dash of turmeric in the occasional recipe may not
have lasting anti-inflammatory effects—unless a person consumes
turmeric or curcumin supplements on a regular basis, too. Here
are 10 proven ways to fight inflammation. Most research says
that taking in at least one gram of curcumin per day is
necessary for measurable anti-inflammatory effects, Webster says
Turmeric benefits: Use this yellow-colored powder
for easing arthritis pain
The Heath Site, January 2019
Many studies have vouched that a key
compound in turmeric known as ‘curcumin’ fight against
inflammation and it is helpful in treating joint disorders like
arthritis. It has the ability to improve joint health and reduce
arthritis pain as well.
Curcumin attenuates hyperglycemia-driven EGF-induced
invasive and migratory abilities of pancreatic cancer
Oncology Report, January 2019
Effects of high glucose were
counter-balanced by curcumin. EGF-induced proliferative,
invasive and migratory abilities of BxPC-3 cells were abrogated
by curcumin, LY 294002 and PD 98059. In addition, EGF-modulated
activation of EGFR, ERK and Akt, as well as the expression of
uPA and E-cadherin were inhibited by curcumin. Taken together,
the present study indicates that curcumin suppresses
hyperglycemia-driven EGF-induced invasion and migration of
pancreatic cancer cells by inhibiting the EGF/EGFR signaling
pathway and its downstream signaling molecules including ERK and
Akt. Curcumin is a potential anticancer agent for pancreatic
cancer.
A Computational Study of the Driving Forces and
Dynamics of Curcumin Binding to Amyloid-β Protofibrils
Journal of Physical Chemistry,
January 2019
We have recently shown that curcumin
exerts a neuroprotective effect against Aβ40 induced toxicity on
cultured neuronal cells through two possible concerted pathways
– ameliorating Aβ oligomer-induced toxicity and inducing the
formation of nontoxic Aβ oligomers, both of which involve
curcumin binding to Aβ oligomers. Our results show that curcumin
binds to specific hydrophobic sites on the protofibril surface
and that binding is generally associated with the concomitant
complexation of curcumin into dimers, trimers, or tetramers.
Curcumin also binds to the protofibril growth axis ends, but
without complexation. Analysis of the energetics of the binding
process revealed that curcumin complexation contributes in an
additive fashion to curcumin - Aβ protofibril interactions.
Favorable curcumin-protofibril binding is driven by a
combination of hydrophobic interactions between curcumin and
protofibril, curcumin self-aggregation, and solvation effects.
Benefits of Turmeric Curcumin for Inflammatory
Orbital Pseudotumor
Care 2, January 2019
Curcumin, the yellow pigment in
turmeric thought to be responsible in part for the spice’s
anti-inflammatory effects. Eighteen patients were given curcumin
alone, and every one improved, showing “efficacy…comparable to
corticosteroid therapy,” but without any side effects. A larger,
follow-up study was similarly encouraging. A total of 106
patients who had had a uveitis relapse in the year before
starting curcumin were followed for a year. As you can see at
1:10 in my video in my video, only 19 had relapses in the year
after starting curcumin. Altogether, the 106 patients had had
multiple relapses—a total of 275 times—in the year before
starting curcumin, but, in the year on curcumin, they had only
36 relapses. If turmeric curcumin works for mild eye
inflammation and serious eye inflammation, what about really
serious eye inflammation, like idiopathic inflammatory orbital
pseudotumours. Let’s break that down: “Idiopathic” means doctors
have no idea what causes it—from the Greek idios, as in idiot.
“Orbital” refers to the bony cavity that houses our eyeball, and
“pseudotumor,” as in not really a tumor. A lot has changed since
the study was published in 2000. “[I]nflammatory orbital
pseudotumour is now generally attributed to low-grade
non-Hodgkin’s lymphoma,” so it does appear to be a form of
cancer. Well, what can curcumin do about it? The researchers
decided to look at curcumin because the available treatments are
so toxic—steroids, radiation, and chemotherapy. In fact, all of
the patients in the study were initially put on steroids but had
to stop them because they either did not work or they had to be
withdrawn because of complications. The researchers didn’t want
to use radiation because they didn’t want to blind anyone. But
they had to do something. All of the patients had so much
swelling that they couldn’t move their eye as they normally
would. If only there were some cheap, simple, and safe solution.
Four out of the five patients who completed the study with
curcumin therapy had a full response, defined as complete
recovery with no residual signs or symptoms. In fact, complete
regression of the eye dislocation and swelling occurred in all
five out of five patients, but one patient continued to suffer
some residual effects.
Curcumin ameliorates monosodium urate-induced gouty
arthritis through Nod-like receptor 3 inflammasome mediation via
inhibiting nuclear factor-kappa B signaling.
Journal of Cellular Biochemisty,
January 2019
Curcumin is an active ingredient
possessing anti-inflammatory efficacy. Curcumin regulated the
production of cytokines by suppressing the expression of
inflammasome key components, including NLRP3, caspase-1. Further
studies showed that the suppressive efficacy of curcumin on
inflammasome was mediated by inhibiting MSU-induced NF-κB
signaling activation. Intraperitoneal administration of curcumin
could ameliorate symptoms of MSU-induced gouty arthritis,
including the joint circumference, infiltration of neutrophils
in knee joints, and production of IL-1β, TNF-α, and elastase.
Western blot analysis revealed that the levels of NLRP3,
procaspase-1, caspase-1, pro-IL-1β, and IL-1β were downregulated
by curcumin in vivo. These results indicated that curcumin could
effectively ameliorate MSU crystal-induced gouty arthritis
through NLRP3 inflammasome mediation via inhibiting NF-κB
signaling both in vitro and in vivo, suggesting a promising
active ingredient for the prevention and treatment of gouty
arthritis.
Impact of dietary supplements, diet on metabolic
health explored in review
Nutritional
Outlook, January 2019
Previous research indicates that
curcumin (Curcuma longa), resveratrol, and quercetin, one of
major flavonoids found in many plants, may exert a beneficial
effect on the above metabolic parameters. Curcumin,
specifically, has a polyphenolic structure with antioxidant and
anti-inflammatory properties, according to a number of the
studies analyzed. Inflammation and oxidative stress are key
contributors to metabolic syndrome and NAFLD.
Curry spice boosts exercise performance
Science Daily, December 2018
New research suggests that
curcumin, a main ingredient in curry, may improve exercise
intolerance related to heart failure. The study is published
ahead of print in the Journal of Applied Physiology. Curcumin, a
chemical that comes from the turmeric plant, has been used as a
traditional Asian medicine for centuries, primarily to treat
gastrointestinal ailments and skin wounds. Studies increasingly
suggest that the compound may prevent or limit muscle wasting
associated with a number of health conditions, including heart
failure. Researchers from the University of Nebraska Medical
Center theorized that a reduction in the normal signaling of
Nrf2, a protein that regulates the expression of antioxidant
enzymes, may play a role in the impaired expression of
antioxidant enzymes. They examined the effects of curcumin,
which is known to promote activation of Nrf2, on a mouse model
of heart failure with reduced ejection fraction. One group of
mice with heart failure received daily doses of curcumin for 12
weeks, and another group did not receive treatment. The heart
failure groups were compared to a control group of healthy mice
that received curcumin and an untreated control group. The
research team measured the exercise capacity of all the mice
before and after curcumin treatment. The researchers also
examined muscle fiber samples to assess enzyme expression
levels. They found that expression of Nrf2 increased and levels
of antioxidant enzymes improved in the animals with heart
failure that were given curcumin. In addition, both groups that
received curcumin -- even the animals without heart failure --
had improved exercise capacity when compared with the untreated
groups, suggesting the effects of curcumin on skeletal muscle is
not exclusive to heart failure. "These data suggest that
activation of Nrf2 in skeletal muscle may represent a novel
therapeutic strategy to improve ... quality of life" in people
with heart failure with reduced ejection fraction, the
researchers wrote.
Curcumin Showing Promise In Alzheimer’s Research
World Health, December 2018
Curcumin/Turmeric has been used
for thousands of years as both food and medicine. Growing bodies
of research are showing it can help to fight Alzheimer’s
disease, not only as a preventive but possibly as a cure. The
potential of turmeric to help combat this debilitating disease
cannot be ignored by mainstream medicine any longer, effects of
this and others like it must be investigated more thoroughly;
and experts are describing the effects of turmeric on
Alzheimer’s patients as being remarkable. Much like most plant
medicines turmeric has been largely ignored thanks to big pharma
and the pharmaceutical industry’s all consuming grip on modern
medicine and the blindly obedient public who follow by shunning
those who dare think outside the sheepeople approved box.
Scientists are beginning to wake up to the fact that medicinal
plants do exist, and some even outperform big pharma’s
concoctions. Recent research has shown that daily turmeric
supplements taken for 12 weeks produced sizeable benefits in
Alzheimer’s patients. Within one year patients began to
recognize family members again according the the researchers. In
all the study yielded impressive and promising results.
Curcumin/turmeric has been studied for ability to help
obliterate cancer, ward off neurodegenerative diseases and more,
it is believed that curcumin extracts its benefits by enhancing
processes associated with chemical signalling in cells and genes
while boosting resistance to inflammation and stress.
Curcumin/turmeric is also thought to help protect brain cells
against premature aging, by binding to toxic proteins to help
prevent forming of dangerous plaques while reducing oxidative
stress and damage, lowering cholesterol, reducing inflammation
signaling molecules, promoting clean up, and inducing protective
mechanisms within the brain. University of Southern California
researchers have also identified curcumin as prime source of
improvement in Alzheimer’s patients via its antioxidant,
anti-inflammatory and lipophilic action. Due to the various
effects of curcumin including delayed degradation of neurons,
metal-chelation, anti-inflammatory, antioxidant and decreased
microglia formation, and decreased beta amyloid plaques overall
memory in Alzheimer’s patients has improved. The team has
concluded that curcumin is a promising treatment for Alzheimer’s
disease.
The natural polyphenol curcumin induces apoptosis in
esophageal squamous cell cancer
Journal of
Experimental & Clinical Cancer Research, December 2018
Curcumin is able to exert anti-tumor action through inhibiting
the STAT3 signaling pathway. Giving its wide use in traditional
medicines with low toxicity and few adverse reactions, it is
conceivable that curcumin might be further explored as a unique
STAT3 inhibitor for anti-cancer therapies.
New research on curcumin’s health benefits
Natural Products Insider, December 2018
Sports nutrition is
an up-and-coming benefit sector for curcumin, especially in
light of its potential to reduce inflammation and soreness
caused by strenuous exercise. The antioxidant benefits of
curcumin and its ability to modulate inflammatory pathways
underscores its potential as an adjunct to recovery.1 In a
recent randomized, double-blind, placebo-controlled study,
curcumin was shown to be an effective supplement for recovery
after strenuous exercise.2 An additional study also reported a
reduction in 24-hour pain scores as well as increased muscle
performance after a muscle-damaging exercise.3 Curcumin is also
finding potential in heart health, where the effects of its
anti-inflammatory properties are being researched. Recently, a
highly bioavailable form of curcumin was studied in a healthy
population to examine its role in endothelial function, which
plays a critical role in cardiovascular health.4 Curcumin’s
direct impact on healthy circulation was measured using flow
mediated dilation (FMD). The randomized, double-blind,
placebo-controlled study showed supplementing with 200 mg of
curcumin had a clinically meaningful impact on potentially
reducing cardiovascular disease by up to 50 percent in healthy
individuals.
Curcumin and Vitamin D Treatment May Stabilize
Disease in Patients with CLL and SLL
Cure
Today, December 2018
In patients with chronic lymphocytic
leukemia (CLL) or small lymphocytic lymphoma (SLL), high doses
of curcumin and vitamin D could help stabilize the disease,
according to new research presented at the American Society of
Hematology’s (ASH) Annual Meeting in San Diego. Previous
clinical studies have shown that curcumin, a chemical derived
from turmeric, and vitamin D are both safe in high doses for
patients with solid tumors. Additionally, the research presented
at ASH notes that curcumin has been found to disrupt CLL cell
interactions, induce cell death independent of DNA damage and
upregulate vitamin D receptor levels in malignant cells. Given
this, the researchers set out to examine whether the combination
of curcumin and vitamin D could safely delay disease progression
in patients with CLL/SLL. In their phase 2, open-label trial,
the team enrolled a total of 35 previously untreated patients
with asymptomatic, stage 0 to 2 CLL/SLL. The majority of
patients (51 percent) were males with CLL (97 percent); 51
percent were stage 0, and 49 percent were stage 1. The median
age was 60 years old. The 30 evaluable patients started out by
receiving 8 grams of curcumin daily for one week, then added
10,000 IU of vitamin D3 orally. Both treatments were taken for
up to six 4-week cycles. Patients received a median of five
cycles, and the treatment was well tolerated. The most frequent
side effects were diarrhea/gastrointestinal upset in 69 percent
of patients, 14 percent of which experienced this at a grade 3.
Eighteen patients completed all six cycles, while 10 withdrew
consent, four discontinued treatment due to adverse effects and
three patients’ disease progressed while on treatment. The
primary endpoint of the study was the overall response rate
(ORR), while secondary endpoints included event-free survival
(EFS), time to next treatment overall survival (OS) and time to
next treatment. Researchers also evaluated the levels of
curcumin and vitamin D activity within CLL cells by using flow
cytometry. The best response was stable disease in 28 of the 30
evaluable patients (93 percent). After a median follow up of 29
months, EFS was 72 percent, 74.1 percent had not started new CLL
treatment, and OS was 100 percent. While no responses were seen,
the majority of evaluable patients maintained stable disease
while in treatment. The researchers concluded that because the
combination of curcumin and high-dose vitamin D is safe and
well-tolerated, additional extended follow up is now planned to
examine how this treatment impacts the long-term progression of
disease in patients with CLL/SLL.
Curcumin prevented human autocrine growth hormone in breast
cancer cells
Molecular Biology Reports,
December 2018
Curcumin (diferuloylmethane), a polyphenol
derived from turmeric (Curcuma longa), has anti-proliferative,
anti-carcinogenic, anti-hormonal effect via acting on PI3K/Akt,
NF-κB and JAK/STAT signaling. This study aimed to investigate
the role of NF-κB signaling and miR-182-96-183 cluster
expression profile on autocrine GH-mediated curcumin resistance,
which was prevented by time-dependent curcumin treatment in T47D
breast cancer cells. Dose- and time-dependent effect of curcumin
on T47D wt and GH+ breast cancer cells were evaluated by MTT
cell viability and trypan blue assay. Apoptotic effect of
curcumin was determined by PI and Annexin V/PI FACS flow
analysis. Immunoblotting performed to investigate the effect of
curcumin on PI3K/Akt/MAPK, NF-κB signaling. miR182-96-183
cluster expression profile was observed by qRT-PCR.
Overexpression of GH triggered resistant profile against
curcumin (20 µM) treatment for 24 h, but this resistance was
accomplished following 48 h curcumin exposure. Concomitantly,
forced GH induced invasion and metastasis through EMT and NF-κB
activation were prevented by long-term curcumin exposure in T47D
cells. Moreover, 48 h curcumin treatment prevented the autocrine
GH-mediated miR-182-96-183 cluster expression stimulation in
T47D cells. In consequence, curcumin treatment for 48 h,
prevented autocrine GH-triggered invasion-metastasis, EMT
activation through inhibiting NF-κB signaling and miR-182-96-183
cluster expression and induced apoptotic cell death by
modulating Bcl-2 family members in T47D breast cancer cells.
Curcumin targets aggressive and lethal forms of
cancer while leaving noncancerous cells unharmed
Natural News, November 2018
Curcumin, the most active
constituent in turmeric, is a powerful antioxidant and is
responsible for most of the spice’s magical health benefits.
Studies have already shown, for example, that curcumin can cut
the growth rate of prostate cancer tumor progression in half.
Other studies have found that supplementing with curcumin can
lead to a 36 percent decline in lung tumor size and a 40 percent
reduction in colon tumor development. In a new study published
in the Proceedings of the National Academy of Sciences,
researchers used models to show how turmeric can inhibit the
DYRK2 enzyme. With the help of x-ray crystallography, they
obtained 3-D images that show curcumin binding to this enzyme
atomically. You might be wondering why we should be excited
about this. It turns out that inhibiting the DYRK2 enzyme stops
protein complexes known as proteasomes that are involved in
cancer development. This action interferes with the
proliferation of cancer cells, reducing tumors and slowing the
cancer’s growth. This is great news for sufferers of
proteasome-addicted cancers, such as triple-negative breast
cancer and multiple myeloma. These cancers depend on the
proteasomes that curcumin inhibits for their survival. While
pharmaceutical proteasome inhibitors do exist, they have the
undesirable effect of also damaging noncancerous cells at the
same time. Curcumin, on the other hand, does this without
damaging any healthy cells. Moreover, it carries very few side
effects and can get the job done in smaller dosages. Perhaps
even more excitingly, this isn’t the only way that curcumin
helps fight cancer. It can also stop the blood vessels that give
tumors life from growing and developing, and it can turn off the
genes that promote the development of tumors. At the same time,
it can help your body’s immune system to find and destroy any
malignant cells. In addition, it can stop the production of the
adhesion molecules that enable cancer cells to stick to cell
walls. It also protects cell DNA from incurring cancerous
mutations from environmental toxins and radiation. In other
words, curcumin takes a multi-pronged approach to fighting
cancer, seemingly trying to stop it at every turn.
Curcumin Inhibits Age Related Vascular Changes
WorldHealth.net November 2018
This study investigated effects
of long term use of curcumin on vascular aging and chronic
inflammation which is the cause of arteriosclerotic disease. 8
week old C57BL/6J mice were fed high fat diets or curcumin mixed
high fat diets until the animals reached 80 weeks of age.
Expression of antioxidant enzymes, heme oxygenase-1, oxidative
stress, vascular aging, and inflammatory changes in the aorta
were examined. Oxidative stress increased with decreases in
sirt1 expression in the aorta, followed by increased amounts of
senescent cells and enhanced inflammation in the animals fed the
high fat diets alone. In the animals fed curcumin mixed high fat
diets heme oxygenase-1 was induced in the aorta with suppression
of oxidative stress; sirt1 expression was shown in the aorta to
remain at a level comparable to that of 8 week old mice with
suppression of increased senescent cells and enhanced
inflammation resolving issues associated with high fat diets.
According to the researchers curcumin may be a food with
prophylactic functions against arteriosclerotic diseases,
helping to control weight gain, increases in blood glucose
levels and blood cholesterol levels associated with long term
consumption of high fat diets; as well as multifaceted benefits
such as anti-cancer effects, anti-inflammatory action, and
antioxidative action, along with various physiological
activities in vivo.
Curcumin Targets Cancer Cells
WorldHealth.net November 2018
Curcumin is a powerful
antioxidant that is attributed to most of the health benefits.
It has been shown to cut growth rates of prostate cancer tumor
progression by 50%; supplementation can lead to 36% decline in
lung cancer tumor size, and 40% reduction in colon tumor
development. In this study researchers used models to show how
turmeric can inhibit DYRK2 enzymes using x-ray crystallography
to obtain 3D images to demonstrate curcumin binding to this
enzyme atomically. Inhibiting these enzymes stops proteasome
protein complexes involved in cancer development, which
interferes with cancer cell proliferation reducing and slowing
cancer growth. Proteasome addicted cancer cells such as triple
negative breast cancer and multiple myeloma depend on
proteasomes for survival that curcumin inhibits. Pharmaceutical
inhibitors do exist, but they also damage healthy cells along
with the cancerous cells at the same time. Curcumin can do this
while leaving healthy cells undisturbed, which is great news.
Not only can curcumin target and help to fight cancer, it helps
to stop blood vessels that give tumors life from growing and
developing, and turns off genes that promote development of
tumors. Curcumin also protects DNA from incurring cancerous
mutations from radiation and environmental toxins. It would seem
curcumin takes multipronged approaches to fighting cancer by
trying to stop it at every turn.
Curcumin very effective senolytic affects
Scienceblog.com November 2018
Recent data suggest that
curcumin, a phytochemical with cancer chemopreventive potential,
might be useful in the treatment of several solid and
hematological malignancies. Overall, this work shows that
curcumin is capable of inducing topo−DNA complexes in cells with
both topo I and topo II and increases the evidence suggesting
that this dietary agent has potential to be tested in cancer
chemotherapy.
This spice helps against tumors
BobrTimes.com November 2018
Curcumin has the property to
engage in connection with a specific enzyme DYRK2 – this
combined substance slows down the activity of cancer cells,
preventing their rapid growth and uncontrolled reproduction in
the body. Laboratory tests have shown that when curcumin is
combined with medicinal substances for the treatment of specific
varieties of tumors of blood, it greatly enhances their
effectiveness and even reduces the side effects.
Curcumin Inhibits Age-Related Vascular Changes in Aged Mice
Fed a High-Fat Diet
Nutrients, November
2018 Inhibiting the onset of arteriosclerotic disease, which
has been increasing due to the westernized diet and aging, is a
significant social challenge. Curcumin, a type of polyphenol,
has anti-oxidative effects and anti-inflammatory action and is
expected to treat and to have prophylactic effects on different
diseases. In this study, we examined the effects of long-term
administration of curcumin on vascular aging and chronic
inflammation—the causes of arteriosclerotic disease. These
results suggest that curcumin might be a food with a
prophylactic function against arteriosclerotic disease.
Ancient drug curcumin impedes 26S proteasome activity by direct
inhibition of dual-specificity tyrosine-regulated kinase 2
PNAS, November 2018
Curcumin, the active ingredient in
Curcuma longa, has been in medicinal use since ancient times.
Interestingly, curcumin synergizes with the therapeutic
proteasome inhibitor carfilzomib to induce apoptosis in a
variety of proteasome-addicted cancer cells, while this drug
combination exhibits modest to no cytotoxicity to noncancerous
cells. In a breast cancer xenograft model, curcumin treatment
significantly reduces tumor burden in immunocompromised mice,
showing a similar antitumor effect as CRISPR/Cas9-mediated DYRK2
depletion. These results reveal an unexpected role of curcumin
in DYRK2-proteasome inhibition and provide a proof-of-concept
that pharmacological manipulation of proteasome regulators may
offer new opportunities for anticancer treatment.
Benefits of Golden
Turmeric Healthline.com October 2018 Research shows that ginger,
cinnamon and curcumin — the active ingredient in turmeric — have
potent anti-inflammatory properties (6,
7,
8).
Studies even suggest that
the anti-inflammatory effects of curcumin are
comparable to those of some pharmaceutical drugs with none
of the side effects (9,
10). These anti-inflammatory effects may reduce joint pain
from osteoarthritis and rheumatoid arthritis.For instance, one
study in 45 people with rheumatoid arthritis found that 500
grams of curcumin daily reduced joint pain more than 50 grams of
a common arthritis drug or a combination of curcumin and the
drug (11).
Similarly, in a 6-week study in 247 people with osteoarthritis,
those given ginger extract experienced less pain and required
less pain medication than those given a placebo (12).
Studies show that curcumin may increase levels of brain-derived
neurotrophic factor (BDNF). BDNF is a compound that helps your
brain form new connections and promotes the growth of brain
cells (13).
Low levels of BDNF may be linked to brain disorders, including
Alzheimer’s disease (14,
15). In a 6-week study, 60 individuals with major depressive
disorders took either curcumin, an antidepressant or a
combination. Those given only curcumin experienced similar
improvements as those given antidepressants, while the
combination group noticed the most benefits (23).
Depression may also be linked to low levels of brain-derived
neurotrophic factor (BDNF). As curcumin appears to boost levels
of BDNF, it may have the potential to reduce symptoms of
depression (24).
curcumin may improve the function of your blood vessel linings —
known as endothelial function. Proper endothelial function is
important for a healthy heart (28).
In one study, people undergoing heart surgery were given either
4 grams of curcumin or a placebo a few days before and after
their surgery. Those given curcumin were 65% less likely to
experience a heart attack during their hospital stay than people
in the placebo group (29).
Curcumin, the active ingredient in turmeric, may also kill
cancerous cells and prevent the growth of new blood vessels in
tumors, limiting their ability to spread (44,
45).
Health Benefits of Turmeric and Curcumin
Mommyish.com October 2018 Turmeric and curcumin are believed to be as effective, if not
more effective, than the most powerful anti-inflammatory drugs.
Curcumin can increase brain-derived neurotrophic factor (BDNF),
a growth hormone that functions in your brain. Low levels of
BDNF have been linked to brain diseases like Alzheimer’s and
depression. Turmeric and curcumin may be effective at delaying
some of those brain diseases, or even reversing them. Curcumin
is a powerful antioxidant that can protect your body from free
radicals, and boost your body’s own antioxidant enzymes. In
addition to improving inflammation and oxidation, turmeric and
curcumin improves the function of the endothelium, which is the
lining of your blood vessels. Endothelial dysfunction is a major
driving force behind heart disease, as it affects your body’s
blood clotting and ability and blood pressure. In one of the
most highly-regarded studies on curcumin, the group who received
a curcumin supplement lowered their risk of heart attack by 65%.
Several studies have shown that curcumin was more effective at
managing the painful symptoms of arthritis than the strongest
anti-inflammatory drugs. In an interesting controlled study,
participants were put into three groups. One group took Prozac,
one group took a curcumin supplement, and one group took both in
conjunction. After six weeks, the group that took curcumin
showed as much improvement as the group that took Prozac. The
group that fared the best in the study was the one that took
both.
10 Things That Happen
When You Eat More Turmeric Readers Digest, October 2018 We all know turmeric is an
anti-inflammatory powerhouse, but do you know which parts of the
body it can benefit the most?
Is it Time for a
Curcumin-Based Mesothelioma Treatment? Surviving Mesotheliom, October 2018 Yet another scientific
study appears to confirm the power of the spice-derived compound
curcumin as a weapon against malignant pleural mesothelioma. The
Chinese researchers who conducted the latest study say the
substance has the potential to be the basis of a whole new way
of treating this aggressive asbestos cancer. This team tested
curcumin on a line of mouse mesothelioma cells, both in the lab
and in live animals, and published their promising results in
the prestigious International Journal of Oncology. As a plant
polyphenol, curcumin has powerful anti-inflammatory and
antioxidant properties and has been the subject of numerous
mesothelioma studies around the world in just the last three
years. Curcumin appears to work in several ways, including
disrupting mesothelioma cell DNA, inducing programmed cell
death, and preventing the formation of a tumor-supporting blood
supply (angiogenesis). Just as importantly — and in sharp
contrast to other types of mesothelioma treatments — curcumin
has very low toxicity. In the current study, Chinese researchers
used a variety of sophisticated testing tools to assess the
impact of curcumin on a mouse mesothelioma cell line. They
applied the compound to cells in the lab and in mesothelioma
tumors implanted under the skin of live mice. They found that
curcumin exerted a range damaging effects on the mesothelioma
cells including: Disruption of vital signaling pathways
Induction of apoptosis Inhibition of blood vessel formation
Prevention of proliferation signals The results prompted lead
author Chengke Zhang of the Department of Thoracic Surgery at
The Second Hospital of Shandong University to conclude,
“Curcumin may be potent enough to be developed as a novel
therapeutic agent for the treatment of malignant pleural
mesothelioma.” A number of previous studies have also suggested
that curcumin has merit as an alternative therapy for
mesothelioma. A study conducted last year at the University of
Rome found that mice infected with peritoneal mesothelioma lived
longer when they were given curcumin. A few months later, French
researchers used curcumin to shrink sarcomatoid tumors in lab
rats. In 2015, researchers in Australia conducted the first
experiments of curcumin on human mesothelioma cells and
concluded that the compound could be a helpful supplement to
standard treatment for certain mesothelioma patients. In another
2015 study, Italian researchers found that curcumin was even
more effective against mesothelioma when delivered into cells
via nanoparticles which overcame cells’ natural resistance to
the compound. Curcumin is of particular interest to mesothelioma
researchers because there are so few viable treatment options
for this deadly cancer.
Curcumin Helping To
Prevent Fluoride Induced Damage In The Brain Worldhealth.net, October 2018 Adding supplementation of
curcumin significantly reduced toxic effects of fluoride to
close to normal levels by augmenting antioxidant defense via its
scavenging properties, and provided evidence of having
therapeutic roles against oxidative stress mediated
neurodegeneration. This is not the only study to demonstrate the
remarkable brain saving properties curcumin possesses; there are
over 200 peer reviewed published studies indicating curcumin is
a neuroprotective agent. When one takes into consideration the
many chemical insults faced on a daily basis in the post
industrial world, turmeric/curcumin may very well be one of the
world’s most important herbs, which has over 800 evidence based
health applications.
Curcumin, Commonly Found In Indian Food, Improves
Memory, Mood, Attention
Studyfinds.com September 2018
Those who took the curcumin
performed better on the cognitive tests, showing better memory
recall and attention spans compared to those who took the
placebo. In fact, individuals in the curcumin group showed an
average of 28 percent improvement on the memory test at 18
months. Thirty participants also agreed to undergo brain scans
to test for levels of amyloid and tau — which are key markers
for Alzheimer’s disease — at the beginning of the study and at
the follow-up period. After 18 months, those who took curcumin
showed much lower levels of the two proteins than those in the
placebo group.
This Spice Can Protect Your Liver
Belmarra Health, September 2018
The latest research findings
uncovered that curcumin may have the potential to protect the
liver from non-alcoholic fatty liver disease (NAFLD) and may
even be a form of treatment. In rat studies, researchers
uncovered that curcumin reduced hepatocellular inflammation
along with providing other benefits.
Role of Curcumin and Gallic acid as antioxidants
PLOS One, September 2018
Curcumin and/or Gallic acid
alleviated the adverse effects caused by tramadol. In addition,
patients should be advice to take Curcumin and/or Gallic acid
prior to tramadol treatment to alleviate the hepatic and renal
toxicities caused by tramadol.
Enhanced anticancer effects of low-dose curcumin
with non-invasive pulsed electric field on PANC-1 cells
Dovepress, September 2018
A non-contact approach using low
intensity electric field in a pulsed waveform could enhance the
anticancer effect of low-dose curcumin on PANC-1 cells through
triggering both extrinsic and intrinsic pathways. The findings
highlight the potential of this alternative treatment,
non-invasive electric field and curcumin, to increase
therapeutic efficacy with minimum cytotoxicity and side effects,
which may provide a new aspect of cancer treatment in
combination of PEF and other anticancer agents.
Chemoprevention of inflammation-related colorectal
cancer by curcumin- and maltodextrin-enriched dietetic
formulation in animal model
Carcinogenesis, September 2018 Seventy were treated with azoxymethane (AOM)/dextran sulfate
sodium and divided into two groups: 35 received standard diet
and 35 enriched formulation (curcumin, boswellic acids,
silymarin and maltodextrins). Our results are promising for a
successful anti-inflammatory and chemopreventive effect of
enriched formulation in CRC arising from inflamed tissue.
Benefits of the Golden Spice Herb: Turmeric
SD Entertainer, August 2018
Turmeric, used in traditional
Chinese medicine, can also be an aid in the stagnation of blood
or even epilepsy, due to its ability to lower blood pressure.
These properties are aided by healing compounds curcuminoids, or
Curcumin which is the active substance in turmeric. In the
article Curcumin: A Review of It’s Effects on Human Health,
Susan Hewlings and Douglas Kalman write, “Curcumin has been
shown to improve systemic markers of oxidative stress. There is
evidence that it can increase serum activities of antioxidants
such as superoxide dismutase.” The possibilities are endless and
this little spice that can help your body heal as well as be a
special tool that can transform your overall health, allowing
you to explore the options of natural remedies when it comes to
your well-being.
This popular spice may prevent diabetes
Bobr Times, August 2018
Curcumin as antioxidant component of
the plant has properties to normalize insulin production, thus
preventing type II diabetes. According to them the action of
curcumin is associated with the reduction of fat content in
tissues – mice this effect was observed even though high-calorie
foods. Preliminary research has also demonstrated anti-cancer
properties of curcumin. Experts from Saint Louis University in
Missouri it was found that part of the substance turmeric
curcumin and silymarin do not allow cancer cells to divide and
thus can help in the treatment and prevention of colon cancer.
Priyanka Chopra is Obsessed With Turmeric Because,
Well, Who Isn’t?
Organic Authority, August
2018 Rich in bioflavonoids, beta-carotene, and vitamins C and
A, as well as a host of other nutrients, its main claim to fame
is the active compound curcumin, which may be responsible for
many of the spices noted health benefits, including
anticarcinogenic properties. A new study seemed to reaffirm the
turmeric’s reputation as an anti-cancer fighter, in addition to
being beneficial in the prevention of chronic disease and
inflammatory conditions like rheumatoid arthritis, IBD and
asthma.
Protect Against 'Evolving Stroke'
NewsMax, August 2018
One type of stroke event is “evolving
stroke.” In these cases, the neurological damage — weakness,
speech impairment — gradually gets worse after the first few
days. When this happens, the penumbra neurons, instead of
returning to normal, start dying off and expanding the damage.
This can occur for a number of reasons, but most often it is
because of a burst of free radicals when the blood supply is
re-established. We call this reperfusion injury. This happens
because of the high oxygen content of the returning blood
flooding the penumbra region, which generates high levels of new
free radicals. Numerous studies have shown that such things as
magnesium, curcumin, quercetin, baicalein, hesperidin,
resveratrol, naringenin, DHA, vitamin E, vitamin C, and
anthocyanadins can prevent this damage and protect the brain
during a stroke. Not only do these compounds suppress free
radicals and lipid peroxidation, they are also powerful
inhibitors of microglial activation and immunoexcitotoxicity.
Adaptogens That Will Improve Your Brain Function
Care2, August 2018
If you haven’t heard, turmeric contains a
compound known as curcumin, which acts as a powerful
anti-inflammatory in the body. What’s more, curcumin also has
neuron stimulating, healing, and protective properties, which is
why it is being researched as a potential healer for those who
have suffered from Alzheimer’s or a stroke. Other research has
shown that curcumin may possess powerful antidepressant
properties, potentially making it a natural, side effect-free
option for those suffering from mild and moderate depression.
Pretty much, if you have an inflammatory condition, curcumin is
on the case.
Curcumin supplementation regulates lipid metabolism
in broiler chickens
Academic, August 2018
Curcumin plays an important role in reduction abdominal fat
deposition by decreasing the hepatic and plasma lipid profile
and affecting the expression levels of genes related to
lipogenesis and lipolysis including ACC, FAS, SREBP-1c, ACLY,
PPARα, and CPT-I.
X-ray Crystallography Reveals How Curcumin Inhibits
Cancer
WorldHealth.net August 2018
X-ray
crystallography and kinase-inhibitor specificity profiling has
revealed that curcumin binds to the kinase enzyme dual
specificity tyrosine regulated kinase at the atomic level, an
interaction that impairs cell proliferation and reduces cancer
burden, as published in the Proceedings of the National Academy
of Sciences. Researchers from the University of California in
collaboration with Peking University and Zhejiang University
discovered the previously unreported co-crystal structure of
curcumin to bind to protein kinase target biochemical
interaction of the naturally occurring turmeric compound binding
to and inhibiting DYRK2 leading to impediment of proteasome; who
also note that curcurmin alone may not be the answer as it is
expelled from the body quickly, to be an effective drug it needs
to be modified to enter the bloodstream and stay long enough to
target cancer. Kinases IKK and GSK3 enzymes were thought to be
curcumin targets leading to anticancer effects, but the
co-crystal structure of curcumin with DYRK2 along with an 140
panel kinase inhibitor profiling has revealed curcumin binds
strongly to active sites of DYRK2 inhibiting it 500 times more
potently than GSK3 or IKK, showing anticancer potential for
chemo-sensitive and proteasome inhibitor resistant and adapted
cancers.
Curcumin: More Powerful Than Drugs
NewsMax, August 2018
Curcumin, an organic compound extracted
from the spice turmeric, is a flavonoid. It is the curcumin that
gives the spice its bright yellow color. Turmeric, a relative of
ginger, is in the family of plants called Zingiberaceae. The
spice turmeric contains a number of beneficial compounds, but
the most important are the curcuminoids: curcumin,
demethyoxycurcumin, and bisdemethoxycurcumin. • Antimalarial •
Antibacterial • Antiviral • Antioxidant • Antiseptic •Anticancer
It is also neuroprotective, lowers cholesterol, and reduces
hardening of the arteries. Studies have shown that this increases curcumin absorption
by 11 times in plasma (the liquid component of blood in which
cells are suspended) and fourfold in the brain. Mixing with oil
also allows concentrations of curcumin to become high enough in
the brain to provide protection against inflammation. Human
studies have shown that even in very high doses (as much as
10,000 mg per day), curcumin has little toxicity. It is very
safe and can even be given intravenously.
Curry powder slows cancer growth
New Telegraph, August 2018
Scientists from the University of
California said a chemical in curry powder could fight cancer.
The scientists have suggested that curcumin, the chemical in
turmeric, could slow the growth of tumours in breast and blood
cancers. Curcumin is a bright yellow chemical produced by some
plants. It is the principal curcuminoid of turmeric, a member of
the ginger family, Zingiberaceae. It is sold as an herbal
supplement, cosmetics ingredient, food flavouring, and food
colouring. It does this by making cancer cells less able to
break down or destroy other cells. Curcumin could be used to
fight cancer because when in the blood stream, it binds to a
specific type of enzyme called DYRK2 and, when the two are
connected, cells cannot reproduce as quickly. Co-author, Jack
Dixon, said curcumin may offer new opportunities for
hard-to-treat triple-negative breast cancer and multiple myeloma
treatment.
Evidence-based complementary treatment of pancreatic
cancer: a review of adjunct therapies including curcumin
Cancer Management and Research, August 2018
Curcumin is the most studied
of the nutraceuticals that are considered anticancer agents
found in natural plants.
Curcumin, from the plant
Curcuma longa and a component of turmeric, has
exhibited multiple anticancer effects in numerous studies in
pancreatic cell lines and mice studies.95–114
When used in combination, curcumin has also been shown to
potentiate the effects of other cytotoxic agents, including
gemcitabine, cisplatin, oxaliplatin, and 5-fluorouracil, in
preclinical models of a variety of cancers.96,105
Most
importantly, it seems to prevent chemoresistance especially to
gemcitabine.102,104–109
A
low incidence of cancer has been documented in countries that
incorporate high consumption of turmeric root, of which curcumin
is believed to be the active ingredient.110,111
After testing >1,000 different potential agents for cancer
prevention, the National Cancer Institute has chosen only 40, of
which curcumin was included, to be moved to clinical trials.112
In several mice studies, curcumin has been shown to prevent
cancer including mammary adenocarcinoma, esophageal cancer, and
familial adenomatous polyposis.113–115Curcumin
has demonstrated a plethora of functions affecting various cell
signaling pathways at multiple levels, as shown in
Figure 3. Studies have identified numerous factors inhibited
by curcumin related to cancer cell survival, proliferation,
invasion, angiogenesis, and metastasis, suppression of
apoptosis, and chemoresistance. Curcumin has been shown to
inhibit a variety of factors including STAT3,100
COX-2,117
survivin,100
miR-200, and miR-21,111
the hedgehog pathway,118
and IAP proteins.119
Additionally, it has been demonstrated to activate the cell
cycle inhibitors, p27 and p27,94
and upregulate the p53 modulator of apoptosis.112
Curcumin has been shown to inhibit pancreatic tumor growth and
angiogenesis in mouse models.120
Curcumin’s most important effect seems to stem from inhibition
of the transcription factor NF-κB and all its downstream
products.96,97,110,117,118
Many lines of evidence suggest that NF-κB plays a major role in
growth, proliferation, angiogenesis, and most importantly,
chemoresistance.104–106,117,121
Becoming resistant to chemotherapy is the main cause of death in
most pancreatic patients. Curcumin seems to block this
resistance.122
For example, one study showed that resistance to gemcitabine is
induced by NF-κB activity and that curcumin inhibits this
process.107
A recent study demonstrated curcumin restores sensitivity in
gemcitabine-resistant cancer cells and confirmed this finding in
a xenograft mouse model.108
Curcumin suppresses the progression of laryngeal
squamous cell carcinoma
OncoTargets and
Therapy, July 2018
Curcumin is a polyphenol extracted from
the rhizomes of Curcuma longa with extensive biological and
pharmacological effects. Curcumin administration upregulated
miR-145 expression in LSCC cells in a dose-dependent manner.
miR-145 overexpression and curcumin treatment both markedly
suppressed cell proliferation, migration and invasion and
induced cell cycle arrest and apoptosis in LSCC cells. Moreover,
curcumin treatment reversed the enhanced effects on cell
viability, migration and invasion and the inhibitory effects on
apoptosis conferred by anti-miR-145 in LSCC cells. Curcumin
treatment dramatically aggravated miR-145-induced inhibition of
the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated
activation of the PI3K/Akt/mTOR pathway in LSCC cells.
Conclusion: Curcumin suppressed LSCC progression through the
upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR
pathway.
Conditions Curcumin Helps Fight
Care2, July 2018
Obesity: If you’re having trouble losing
weight you might want to consider adding more turmeric to your
diet and supplementing with curcumin. That’s because research in
the journal Biofactors found that the spice alleviated the
inflammation isolated as a cause in overweight and obesity. It
not only helped with obesity, it helped to protect against some
of the health-damaging effects of obesity. Ideally choose a
standardized extract of curcumin.
Memory Boosting: Research
published in the Journal of Psychopharmacology showed that
within only one hour after taking a supplement containing one of
turmeric’s active ingredients, curcumin, study participants had
a significant improvement in memory and attention tasks compared
to the placebo group.
Alzheimer’s Protection: Research shows
that the curcumin may even help to protect the brain against the
plaque-formation found in Alzheimer’s disease. It seems to work
by preventing the formation of beta amyloid plaques—which are
key factors in Alzheimer’s disease. Even Alzheimer’s patients
who exhibited severe symptoms, including: dementia,
irritability, agitation, anxiety and apathy, had excellent
therapeutic results when taking curcumin, according to another
study published in the Japanese medical journal known as Ayu.
Colon Cancer Prevention and Treatment: Curcumin not only shows
benefits for prostate cancer, it has been found in multiple
studies to reduce colon cancer risk. In one study published in
Cancer Prevention Research researchers found that curcumin
suppressed the ability of colon cancer cells to proliferate,
suggesting it may be beneficial in preventing and treating the
disease.
Tendonitis: A root similar to gingerroot, turmeric
contains a potent compound that, not only gives it its signature
yellow color, but also its anti-inflammatory properties. In a
study published in the Journal of Biological Chemistry
researchers found that curcumin improved the healing of
tendonitis, which involves inflammation of the tendons that help
maintain our structural integrity.
Urinary Tract Infections:
Recent research in the Journal of International Molecular
Sciences found that curcumin helps to prevent kidney stones from
forming in the urinary tract. It appears to prevent them from
crystallizing in the first place.
Curcumin increases glutathione production
Inside Tucson, July 2018
The UA College of Nursing recently
received a 1.6 million dollar grant to research the potential of
curcumin at combatting the acute lung injury. This five-year
grant from the National Institutes of Health allows researchers
to study whether the non-pharmacological supplement curcumin can
be used as medicine against the disease. Alcohol abuse depletes
cells’ glutathione, an important antioxidant in the lung.
Research shows when glutathione combines with oxygen, it can
result in fatal respiratory failure. Curcumin, naturally found
in turmeric, has proven effective as a non-pharmacological
treatment for a variety of inflammatory diseases, and increases
glutathione production.
Anti-Cancer Mechanism of Curcumin Outlined
MedicalResearch.com July 2018
Curcumin is good for cancer
prevention since it blocks inflammation and tumor cell
metabolism. These two activities are likely to prevent cancer or
at least to delay its development. Consider that delaying cancer
development means years of healthy life while cancer therapy
means life with cancer, which is not the same. We are working
with pure curcumin, no derivates, no additives with commercial
interest.
University of Arizona Awarded Grant To Research
Healing Powers Of Curcumin
KJZZ, July 2018
The University of Arizona College of Nursing was awarded a $1.6
million grant to research the healing potential of the substance
curcumin for acute lung injury. Acute respiratory distress
syndrome can be lethal and is expensive to treat. Researcher Dr.
Charles Downs said he hopes the study will lead to the
development of a cure. “It looks like it may hold some promise
in this area primarily because of its antioxidants and
beneficial effects,” said Downs. Curcumin is a compound found in
the spice turmeric and has been used to reduce inflammation.
What exactly is curcumin and what is it good for?
Mind Body Green, July 2018
Turmeric is a rhizome
(underground root stem) of the leafy Curcuma longa plant. Also
known as Indian saffron, turmeric has been a must-have
ingredient in Indian cooking and medicine for thousands of
years. Curcumin, the powerful medicinal compound that gives
turmeric its health benefits, is best consumed in food, with fat
and pepper.
Curcumin can shrink tumors
San Diego Tribune, July 2018
In one clinical study on
pancreatic cancer, two patients out of 25 had good responses to
large, daily doses of curcumin. Those two experienced tumor
shrinkage for three years. “That doesn’t sound like a lot but
most drugs won’t work very well for pancreatic cancer.” Curcumin
turns off something called NF-kappa B that increases the
production of several types of proteins that promote tumor
growth. Second, it promotes apoptosis, which is the programmed
death of cells in our bodies. Apopstosis is halted in cancer
cells, allowing them to flourish. Curcumin reinvigorates that
programmed cell death.
Can curcumin really help with arthritis,
inflammation and headaches?
WKTR, July 2018
"Turmeric contains the chemical curcumin, found safe in six
human trials," explained Dr. Light. "Curcumin, when studied,
demonstrated anti-inflammatory activity inhibiting different
parts of the inflammatory system. Turmeric can be used as an
anti-inflammatory and may lessen the symptoms of arthritis and
headache caused by inflammation."
UA receives $1.6m grant to examine the healing
potential of curcumin for acute lung injury
Eureka Alert, July 2018
Curcumin, a compound found in
turmeric, has proven effective as a nonpharmacological treatment
for a variety of inflammatory diseases, and an increase of GSH
synthesis. Looking to evaluate curcumin's effectiveness in
facilitating the normal production of GSH, University of Arizona
College of Nursing Assistant Professor Charles Downs, PhD,
ACNP-BC, FAAN, has received a five-year $1.6M RO1 grant from the
National Institutes of Health. Using a carefully designed murine
model in his study, "Using Proteomics to Develop Personalized
Health Strategies to Prevent Lung Injury in Model Systems," Dr.
Downs hopes to demonstrate that curcumin reverses impaired
protein function to restore lung fluid balance. Acute
respiratory distress syndrome occurs in response to inflammatory
stresses such as pneumonia and is characterized by profound
inflammation and a build-up of excess fluid in the lungs that
culminates in respiratory failure. Although researchers are
aware of the physiological disorders associated with the
syndrome, current therapies are supportive rather than curative,
Dr. Downs said.
Value Your Memory? These Nutrients Will Keep It
Strong
ZME Science, June 2018
Curcumin, the compound that makes
turmeric bright yellow, has been in the news a lot lately
because of its health benefits, and many of those benefits
center on the brain. In particular, curcumin can reduce brain
inflammation and increase the availability of the antioxidant
glutathione. Brain inflammation is a leading cause of
neurological damage and degeneration, so find a way to work it
into your diet, whether in curry, golden milk, or as a
stand-alone supplement. If you are going to take curcumin as a
supplement, consider mixing it with coconut oil, olive oil, or
even that brain health booster fish oil for improved absorption.
Muscle Atrophy Cures
Found At The Supermarket The Eagle, June 2018 Our lab has shown a causal role that
reactive oxygen species (ROS) play in starting and maintaining
this atrophy process. ROS are generated through metabolic and
chemical reactions in the body and are normally referred to as
free radicals in the general population. Disuse results in a
spike of ROS and this causes movement of an enzyme nNOS
(neuronal nitric oxide synthase) from the cell membrane to the
interior of the cell. This movement of a molecule that normally
resides at the cell membrane sets off a cascade of intracellular
events that lead to the breakdown of the muscle cell. Our
interventions of fish oil and curcumin aim at scavenging these
excess ROS. By dealing with the high levels of ROS we can
mitigate the cellular processes that lead to muscle breakdown
and preserve muscle mass. It’s also important to note that these
two interventions have been shown to diminish muscle atrophy
when used alone and our lab wanted to see if combining both
treatments would result in a more profound “rescue effect.” This
intervention experiment is also important because many drugs
created to combat muscle atrophy are quite expensive and often
times have negative side effects. Fish oil and curcumin are not
toxic and are easily available to any average person shopping at
the local Wal-Mart.
Curcumin
Health Benefits
SimpleMost.com June 2018 One of
the star ingredients here is turmeric, and specifically the
curcumin present in the golden spice. A 2013 study showed that
curcumin has therapeutic properties for human diseases such as
cancer and Alzheimer’s. Curcumin also offers a number of other
health benefits, including increased antioxidant capacity of the
body and the ability to neutralize free radicals. It’s also said
to improve brain function, lower the risk of heart disease and
help those suffering from arthritis by reducing inflammation.
Plants That Help Your
Brain and Memory Care2, June 2018 Curcumin, the active ingredient in turmeric,
has been linked to a wide variety of health benefits. One study
found that participants had significantly improved memory and
attention within one hour after taking a curcumin supplement.
Four weeks on the supplement enhanced their working memory,
energy levels and calmness as well as lowered their stress
levels.
Turmeric – What is That? Kiowa County Press, June 2018 Curcumin is what gives turmeric
its yellow-orange coloring. Curcumin is the active ingredient
found in turmeric. It has been said that it may be a contributor
to helping break down fat cells in your body; and, because of
its natural anti-inflammatory agents, turmeric may help reduce
joint and muscle pain. Other positive effects of curcumin
include aiding in digestion, lower cholesterol, relief of
arthritis and cystic fibrosis symptoms, prevention of some
cancers, and lower blood pressure.
Reduce your risk of getting cancer
NZ Herald, May 2018
Healthista's nutrition director,
Rick Hay, has shared what foods are best for a cancer awareness
diet and 10 tips to help boost your health. "Top of my herb and
spice list is turmeric," says Hay. "The active ingredient is
curcumin which is a key anti-inflammatory agent." Curcumin can
stop cancer cells and tumours from growing, especially in
regards to breast, bowel and skin cancer cells. Black pepper is
also beneficial in helping the body to absorb curcumin.
Anti-inflammatory Turmeric Protects Against Diabetes
ReliaWire.com May 2018
Curcumin is the main active
ingredient in turmeric, which has proven anti-inflammatory and
anti-oxidant properties. This naturally sourced and bioactive
compound is easy to produce, has no side effects and can help to
reduce inflammation in an array of inflammatory diseases;
including obesity and diabetes. Scientists from Shandong
University in Jinan, China found that curcumin improved glucose
tolerance and insulin sensitivity in mice that were fed a high
fat diet; and that blocking activation of the NLRP3 inflammasome
was key to preventing high fat diet-induced insulin resistance.
Top 3 Signs of Ageing: Why This Spice Could Be You
Best Anti-Ageing Companion
NDTV May 2018
Curcumin In Turmeric May Boost
Memory and Uplift Mood too, claimed a recent study. The study,
published in the American Journal of Geriatric Psychiatry,
examined 40 adults between the ages of 50 and 90 years who had
mild memory complaints.For the study, they were randomly
assigned to receive either a placebo or 90 milligrammes of
curcumin twice daily for 18 months. People taking curcumin
improved by 28 per cent over the 18 months in their memory
tests. There were mild improvements in mood for people taking
curcumin. According to the researchers, taking this relatively
safe form of curcumin could provide meaningful cognitive
benefits over the years. One of the bets way to include Haldi in
your diet is through Haldi doodh. According to Ayurveda expert
Ashutosh Gautam, "It is because curcumin has the ability to get
absorbed in the fat and tissues of our body and that is how it
benefits the body. Milk becomes a smooth medium through which
curcumin travels better and speedier to those fats and tissues
facilitating its better absorption".
Why Turmeric Is the Golden Spice That'll Make Your
Health Nice
PopSugar, May
2018
The active compound in turmeric,
curcumin, is great at decreasing exercise-related muscle
soreness due to its antioxidant properties. It also helps boost
muscle recovery so you can get back to the gym right away. If
your gut is easily irritated by certain foods, adding turmeric
to your dish or having it as a shot before will help a lot with
any bloat. Curcumin works by inhibiting enzymes that increase
inflammation in the body.
Healthy Living: Turmeric, more than a spice
News Tribune, May 2018
Several studies on the effects of
turmeric's active compound curcumin found reduced inflammation
in people with osteoarthritis of the knee. Both pain and
C-reactive protein levels were lowered. Testing showed collagen
breakdown and overall disease activity was reduced.
Additionally, research on rheumatoid arthritis found some
patients found the anti-inflammatory properties as beneficial as
cortisone. How? Turmeric inhibits the breakdown of arachidonic
acid. Turmeric's combination of antioxidant and
anti-inflammatory effects explains why many people with joint
disease find relief when they use the spice regularly. Turmeric
can offer help with several digestive issues. The University of
Maryland Medical Center reported the curcumin in turmeric
stimulates the gallbladder to produce more bile. This may help
improve gas, bloating, nausea, appetite loss, belching and
stomach discomfort. The curcumin may also be beneficial in
inflammatory bowel diseases, including Crohn's disease and
ulcerative colitis. However, turmeric should not be used with
stomach ulcers, as it may increase stomach acid in some people.
Turmeric also has been shown to lower blood sugar and LDL
cholesterol. It also keeps platelets from clumping together,
meaning it might stop blood clots from forming on your artery
walls. Because of this people currently using blood-thinning
drugs should be aware the effect might be intensified with
turmeric. Interactions of curcumin within the body improve
insulin resistance, hyperglycemia, hyperlipidemia and other
inflammatory symptoms associated with obesity and metabolic
disorders. In addition, studies show curcumin seems to delay
liver damage that can eventually lead to cirrhosis. Clinical
studies have shown frequent use of turmeric to lower rates of
breast, prostate, lung and colon cancer.
Herbs that can give your weight loss plan a boost
Times of India, May 2018
According to a 2009 study by Tufts
University, turmeric can help your body burn fat. In the study,
there were two groups of mice, one was fed curcumin while the
other wasn’t. The results were that the group of mice that had
curcumin lost more weight than the other group that did not have
it. Turmeric is a warming spice, it increases the body heat
which can boost your metabolism and provide other health
benefits.
Healthy haldi
Times of India, May 2018
Curcumin’s anti-inflammatory
properties make it an effective immunity booster, mitigating
incidences of infection, disease. Curcumin helps block the
conditions that lead to cardiovascular damage, which helps
manage blood pressure and reduces the formation of clots. More
and more studies are making linkages between haldi and its
positive effect on anxiety. Curcumin seems to boost serotonin –
the happy hormone, while lowering cortisol – the stress hormone.
It is the curcumin in turmeric that gives it its antioxidant
properties. Oxidative damage (the chemical reactions that oxygen
performs inside our bodies) leads to the development and
proliferation of free radicals, which are highly reactive
molecules. Free radicals have the potential to damage organs and
also create a crazy, disease-prone, inflamed environment inside
our body. Antioxidants help flush out free radicals and also
work as a brilliant anti-inflammatory.
5 Foods for Joint Pain Relief
NewsMax, May 2018
The active ingredient in turmeric is
curcumin, which has been shown to suppress the action of a
number of chemical signals in the body, such as tumor necrosis
factor, that attack joints. Curcumin also blocks other
inflammatory signals, including those in the pro-inflammatory
COX-2 pathway. A study presented in the journal, Experimental
Neurology (2016), revealed that curcumin counteracted the
outcome of traumatic brain injury by decreasing oxidative
stress, and increasing synaptic simplicity and cognition.
Turmeric also stimulates a key antioxidant pathway called Nrf2.
A healthy heart diet
MVariety.com May 2018
“A study of about 121 patients
undergoing coronary artery bypass disease showed a positive
response to turmeric. There was a 65 percent decreased heart
attack rate for patients who were given a dose every day.”
Forsyth said curcumin, a substance in turmeric, has a positive
effect on your endothelium, which is the lining of your blood
vessels. Endothelium is responsible for regulating blood clots,
blood pressure, and all other factors that lead to many heart
diseases. Researchers at the University of Toronto found that
curcumin blocks a wide range of biochemical reactions involved
in cardiac hypertrophy (enlargement of the heart chambers),
inflammation, and fibrosis.
Feed your brain well
Times of
India, May 2018
Curcumin: It is the active ingredient
in turmeric. Curcumin has been shown to boost BDNF
(Brain-Derived Neurotrophic Factor), which helps lower the risk
of brain diseases. Curcumin works best when heated with food. It
is known to add to brain clarity and reduce mind fogginess.
To stay healthy, include natural spices in your diet
Daily Nation, May 2018
der. Curcumin is a chemical compound
found in turmeric, this compound is responsible for the
anti-inflammatory, anti-cancer and antioxidant properties of
turmeric. In isolation, absorption of curcumin in blood stream
is low, however, the absorption can be enhanced by piperine
found in black pepper. As an anti-inflammatory agent, curcumin
attacks the inflammatory pathway, on this pathway, it blocks the
NF-kB molecule from accessing the cell nuclei. It is in the
nuclei where the NF-Kb molecule triggers the gene associated
inflammation, which causes chronic diseases. Curcumin has a
chemical structure that has the ability to inhibit the three
major enzymes (lipoxygenase, cyclooxygenase-2 and inducible
nitric oxide synthase) that promote inflammatory process. Other
disorders whose risks can be reduced by curcumin include heart
and brain diseases, osteoarthritis, depression, eye swelling,
skin cancer and age-related ailments.
Here's how Turmeric can help you lose weight
E Times, May 2018
The primary antioxidant present in turmeric
is curcumin. Turmeric is said to help one deal with stomach
issues, metabolic disorders, obesity and many more problems.
Though having huge quantities of turmeric is surely not a way to
lose weight, but turmeric is said to reduce the inflammation
associated with obesity. Thus, it can give your weight loss plan
a boost. Obesity leads to inflammation, which increases
your risk of developing chronic diseases, including diabetes and
heart disease. Curcumin, which is an antioxidant, suppresses the
inflammatory messaging in fat, pancreatic and muscle cells. This
can help reduce high blood pressure, high cholesterol, high
blood sugar and other metabolic conditions, says a study
published in European Journal of Nutrition.
Turmeric use linked to weight loss
Citizen Digital, May 2018
Curcumin, an active ingredient in
Turmeric, has a strong anti-oxidant property. This article
highlights the various benefits of using the spice: prevents
heart diseases improves immunity aids in weight loss and
metabolism prevents neurological diseases promotes brain health
prevents cancer offers excellent anti-oxidant properties delays
aging can be used as a natural painkiller treats skin
pigmentation prevents hair loss helps treat dandruff cures
stretch marks soothes burns heals cracked feet aids in
exfoliation aids in diabetes treatment works as a natural
antiseptic detoxifies the liver reduces menstrual pain treats
digestive disorders.
Want to fight your everyday blues? These kitchen
ingredients may be the perfect solution for you
TimesNowNews, April 2018
Turmeric is a widely used spice in
Indian households. Apart from its anti-inflammatory nature, the
spice also brings a distinct flavour and aroma to your meal
which has mood-lifting properties. There is a compound called
curcumin that has been linked to improving mood, according to a
study conducted by UCLA. “Exactly how curcumin exerts its
effects is not certain, but it may be due to its ability to
reduce brain inflammation, which has been linked to both
Alzheimer’s disease and major depression,” said Dr Gary Small,
director of geriatric psychiatry at UCLA’s Longevity Center and
of the geriatric psychiatry division.
Curcumin and a good book
News
Miner, April 2018
Cumin and curcumin, which is found in
turmeric, are both important ingredients in cuisines from North
Africa to India, and both possess powerful medicinal qualities.
Research at UCLA has shown curcumin has “improved memory and
mood in people with mild, age-related memory loss.” Already
known for its anti-inflammatory and antioxidant properties,
eating lots of curcumin-rich turmeric “has been suggested as a
possible reason that senior citizens in India, where curcumin is
a dietary staple, have a lower prevalence of Alzheimer’s disease
and better cognitive performance.”
Is turmeric really a 'wonder drug' for migraines?
Daily Mail, April 2018
Good brands for curcumin will give you
the milligram dosage of curcumin specifically listed on the
bottle which is why she recommends people buy curcumin
supplements as opposed to turmeric. Although more research is
needed to prove curcumin's effectiveness, Dr Green said that in
addition to other prescriptions, she prescribes it to her
patients to treat migraines. She said it does make her patients
feel better. She said she uses it as a preventive measure for
patients who experience 14 migraines or less per month.
'Prevention then becomes imperative for many of these patients,
and while there are a slew of prescription medications we can
use for prevention, increasingly people are looking for
alternatives,' Dr Green said. Rissetto said other health
benefits associated with curcumin includes, a boost in brain
function and a lower risk of developing brain diseases like
Alzheimer's disease. A 2008 study published in the Annals of
Indian Academy of Neurology found that curcumin decreased
Beta-amyloid plaques, which is a hallmark of Alzheimer's. She
said it has also been linked to improved heart function.
Spice is able to prevent dementia
Siv Times, April 2018
Curcumin is a component of well-known
condiments, recently conducted a lot of research about its
positive and negative effects on health, reports the
Chronicle.info with reference to ladyhealth.com.ua. Scientists
from Israel have also contributed, showing that curcumin helps
to maintain brain health and reduces the risk of development of
Alzheimer’s and Parkinson’s. Scientists from an Israeli hospital
Hadassah has tested the potential of dietary supplements to
strengthen the intestinal cells to prevent uncontrolled leakage
of intestinal contents into the bloodstream. In combination with
phospholipids, curcumin showed anti-inflammatory properties,
ability to reduce the intervals between the cells and make the
intestines less permeable. The disadvantage of curcumin is rapid
decomposition and removal within two hours. However, its
positive effect lasts for 72 hours even after complete removal.
Key curry ingredient could have amazing health
benefits – and improve memory
Mirror, April
2018 Curcumin has been analysed in a study published in the
American Journal of Geriatric Psychiatry. Scientists at the
University of California in Los Angeles examined the effects of
the ingredient on people with mild and age-related memory loss.
"Exactly how curcumin exerts its effects is not certain, but it
may be due to its ability to reduce brain inflammation, which
has been linked to both Alzheimer's disease and major
depression," said Dr. Gary Small, study author and the director
of geriatric psychiatry at UCLA's Longevity Center. In total, 40
participants aged between 50 and 90-years-old, each with mild
memory loss and/or complaints, were brought in. Half were
assigned 90 milligrams of curcumin twice daily for 18 months;
the rest were given a placebo. Researchers found that those who
took curcumin saw improvement in both memory and mood. The
substance levels in their blood was monitored, while cognitive
assessments and PET scans were undertaken too. The study says
that memory tests show people taking curcumin improved by as
much as 28 per cent over the timeframe. Their overall
disposition also improved, according to scientists. The
university plans to continue its research and conduct a second
study with a greater number of participants. Also to be explored
is whether curcumin works better in certain ages, its impact on
those with a genetic risk of dementia, and if it can be used to
treat people with depression. Dr Small said: "These results
suggest that taking this relatively safe form of curcumin could
provide meaningful cognitive benefits over the years."
Fighting for those who fought
The Batt, April 2018
The study, funded by the Department of
Veteran Affairs (VA) and the Department of Defense, focused on a
curcumin, a component of turmeric. Turmeric is a spice found in
curry and has many health benefits that could help with the
disease long term. The spice has been used in animal models and
has shown signs of reversing GWI. “We were very pleased in our
tests that curcumin showed better signs of reactions among
animals than the true control group,” Shetty said. “That can
lead us to believe there is good ahead in or long road of
discoveries and studies.”
Can Turmeric Bring the Fight to Mesothelioma?
Asbestos.com April 2018
There are two
aspects to the 2017 turmeric and mesothelioma experiment. In
both parts, the researchers focused on curcumin, a substance
found in abundance in turmeric. First, they studied how curcumin
curbs cell growth in mesothelioma cancer. The researchers found
the spice component thwarted mesothelioma. Next, researchers
examined how curcumin protected mice against mesothelioma tumor
development. Compared with the mice who received plain corn oil,
the mice who received the intraperitoneal curcumin and corn oil
mixture: Experienced reduced risk of developing tumors overall,
Developed fewer tumors, Had much smaller tumors, Lived
significantly longer.
Add turmeric to your diet to improve your well-being
The Gauntlet, April 2018
Kris Gunnars of the health-care blog
Authority Nutrition says that turmeric is rich in a powerful
anti-inflammatory called curcumin. Gunnars says that curcumin is
equally as effective at fighting inflammation as pharmaceuticals
— but without the nasty headaches and stomach pain that they
typically cause.
Why Turmeric Is Good For High Blood Pressure
NDTV, April 2018
Turmeric is popular for its antioxidant
curcumin which helps in lowering blood pressure. Its antioxidant
properties are the responsible for regulating blood pressure in
the body. Curcumin also protects against vascular dysfunction in
the body. Having high blood pressure in this case, causes
further damage to tissues in arteries. LDL (or bad) cholesterol
begins to deposit in arteries in the form of plaque in the walls
of arteries. Curcumin in turmeric can help in preventing further
damage caused to arteries because of high blood pressure. The
anti-inflammatory property of turmeric is another reason which
contributes to the popularity of the spice. Curcumin has
anti-inflammatory properties which help in keeping hypertension
at bay. Inflammation in the body is risky because it can
contribute to stiffness in heart's arteries - which in turn may
raise blood pressure. Consuming turmeric regularly can help in
keeping blood pressure under control.
Focus on Fitness: Boosting memory and avoiding
obesity
Plant City Observer, April 2018
Scientists at UCLA worked with 40 volunteers, age 50 through 90,
who all had memory loss complaints. Their study, published in
January in the American Journal of Geriatric Psychiatry, found
using curcumin twice a day for 18 months improved memory and
mood tests, as well as brain scans. Curcumin is the active
ingredient in the Indian spice turmeric. Besides cooking
applications, turmeric has been used by ancient cultures for
brain health for many centuries. Turmeric gives Indian curry its
color and flavor. Manufacturers often use turmeric to color
cheese, butter and prepared mustard. Known as a powerful
antioxidant, curcumin scavenges free radicals in the human body
to stop cell membrane damage. Curcumin lowers inflammation by
reducing the enzymes that cause it. Chinese and Ayurvedic
medicine systems also use turmeric to treat digestive and liver
conditions as well as wounds and skin diseases. If you decide to
take curcumin vitamin capsules, select a quality product from a
reputable manufacturer.
Arthritis symptoms, spice could prevent joint pain
Express, April 2018
One compound within the spice - curcumin
- has pain-relieving characteristics that may help to relieve
arthritis suffering. Curcumin is also one of the most effective
anti-inflammatory compounds in the world, researchers said. The
compound may even be beneficial for Alzheimer’s disease
patients. Turmeric is a yellow powder that works an an
anti-inflammatory, scientists have claimed. One compound within
the spice - curcumin - has pain-relieving characteristics that
may help to relieve arthritis suffering. Curcumin is also one of
the most effective anti-inflammatory compounds in the world,
researchers said. “While arthritis cannot be cured, it seems
that a high dose of curcumin can be just as [or more] effective
than at least the most common medication prescribed for the
condition. “Turmeric comes from India and other Southeast Asian
countries. The dried root of the Curcuma longa plant is ground
into the distinctive yellow turmeric powder. “The best part
about turmeric? Not only is it well-researched, incredibly
potent and historically significant, it’s also safe.”
Curcumin Suppresses IL-1β Secretion and Prevents
Inflammation
Journal of Immunology, April
2018 Turmeric is traditionally used as a spice and coloring
in foods. Curcumin is the primary active ingredient in the
turmeric, and compelling evidence has shown that it has the
ability to inhibit inflammation. We report that curcumin
inhibited caspase-1 activation and IL-1β secretion through
suppressing LPS priming and the inflammasome activation pathway
in mouse bone marrow–derived macrophages. The inhibitory effect
of curcumin on inflammasome activation was specific to the
NLRP3, not to the NLRC4 or the AIM2 inflammasomes. Curcumin
inhibited the NLRP3 inflammasome by preventing K+ efflux and
disturbing the downstream events, including the efficient
spatial arrangement of mitochondria, ASC oligomerization, and
speckle formation. Reactive oxygen species, autophagy,
sirtuin-2, or acetylated α-tubulin was ruled out as the
mechanism by which curcumin inhibits the inflammasome.
Importantly, in vivo data show that curcumin attenuated IL-1β
secretion and prevented high-fat diet–induced insulin resistance
in wide-type C57BL/6 mice but not in Nlrp3-deficient mice.
Curcumin also repressed monosodium urate crystal–induced
peritoneal inflammation in vivo. Taken together, we identified
curcumin as a common NLRP3 inflammasome activation inhibitor.
Our findings reveal a mechanism through which curcumin represses
inflammation and suggest the potential clinical use of curcumin
in NLRP3-driven diseases.
Turmeric linked to avert the risk of cardiovascular
diseases, the recent study claims
AskTelegraph.com March 2018
Benefits of curcumin: Curcumin
has anti-inflammatory, anti-allergic, anti-microbial, and
antioxidant properties that help in blood clotting. It can act
as a substitute for aspirin. Helps in treating of bone or joint
disorders such as arthritis, osteoarthritis and rheumatoid
arthritis at the faster rate. It also helps in fighting against
skin infections and skin disorders. “Clinical trials reveal that
consuming 4 grams of turmeric continuously for 4 days before
surgery and 5 days’ post-surgery can reduce the risk of
myocardial infarction and chances of by-pass surgery by 56
percent as compared to placebo”, discloses Natural Medicines
Database. Since curcumin compound found in turmeric has
antioxidant properties, it can help in the oxidation of vital
body parts thus dropping the chances of deadly cancer.
Additionally, consuming 1.4 grams of turmeric on daily basis can
help to thwart low-density lipoprotein (LDL), total cholesterol,
triglyceride and very low-density lipoprotein (VLDL) cholesterol
in individuals.
How this spice can give you an added health boost
Belfast Telegraph, March 2018
Researchers have found that
curcumin, the bright yellow chemical produced by turmeric, is
capable of interacting with a variety of molecules involved in
inflammation, easing swelling, aches and pains in the joints and
muscles. In fact, a study published in the National Center for
Biotechnology Information found that cucurmin may be just as
effective as aspirin and ibuprofen at suppressing the body’s
inflammatory response. As well as bolstering the body’s natural
antioxidant function by increasing glutathione levels, studies
found curcumin’s molecular structure can neutralise harmful free
radicals in the body, lessening the chances of disease. Multiple
studies have found that the yellow pigment in turmeric root can
help to maintain the function of the interior lining of your
blood vessels. One study published in the Nutrition Research
journal in 2012 even found that curcumin may be as effective in
improving vascular function in post-menopausal women as a
moderate exercise routine.
Turmeric component may ease Gulf War illness for
vets
Futurity March 2018
We found the
individuals with GWI treated with curcumin for 30 days showed
better cognitive function and mood than the control group did.”
The improvements were more than just functional. “Curcumin
treatment helped in alleviating the brain inflammation seen in
GWI,” says first author Maheedhar Kodali, a postdoctoral fellow.
“It also enhanced the expression of genes that encode for
antioxidants and normalized the expression of genes related to
the function of mitochondria in the hippocampus.” “Particularly,
the ability of curcumin to reduce the occurrence of activated
microglia, a sign of eased brain inflammation, is remarkable,”
Shetty says. The compound also seemed to enhance the formation
of new neurons in the hippocampus, the part of the brain
responsible for learning, memory, and mood and the region where
new neurons are added throughout life in normal individuals.
Could a spice be the key to helping Gulf War Illness
vets?
KCEN TV, March 2018
"Curcumin has
been known to have antioxidant, anti-inflammatory and neurogenic
properties, so that's why we thought it's a good candidate for
testing," Shetty said. Doctor Shetty said, based on their recent
studies, the bright yellow chemical in the spice is shown to
improve cognitive function, reduce brain inflammation and act as
an antioxidant. He went on to say it helped create new neurons
in the brain. There is not one specific treatment for Gulf War
Illness at this time. "We tested the efficacy of circumin
immediately after the exposure to Gulf War illness-related
chemicals. And we found the animals can maintain better
cognitive function and reduce depressor-like behavior," Shetty
said. The scientist went as far to say curcumin may even have
the potential to prevent Alzheimer's disease, according to
recent studies.
Curcumin treatment leads to better cognitive and
mood function in a model of Gulf War Illness with enhanced
neurogenesis, and alleviation of inflammation and mitochondrial
dysfunction in the hippocampus
Science
Direct, March 2018
This study showed that curcumin can
mediate anti-inflammatory, antioxidant, neurogenic, and
cognitive and mood enhancing effects in a condition such as
GWI,” Shetty says. The findings correspond well with those of a
separate study in humans from the University of California, Los
Angeles, which recently showed curcumin improved the cognitive
function of older adults by 28 percent. Curcumin maintains
better cognitive and mood function in a model of Gulf War
Illness. Curcumin alleviates neuroinflammation in a model of
Gulf War Illness. Curcumin enhances hippocampal neurogenesis in
a model of Gulf War Illness. Curcumin normalizes mitochondrial
function in a model of Gulf War Illness. Curcumin enhances the
expression of genes that encode antioxidant activity.
Eating Healthy And Natural May Keep Cancer At Bay
NDTV, March 2018
Curcumin, an active compound found in
turmeric may help keep cancer at bay to a certain extent.
Curcumin helps inhibit the growth of various cancer cells in
most parts of the body. It is known to have anti-cancerous
properties.
Natural supplements to stop lower back pain
Express, March 2018
Turmeric is the spice that gives curry
its yellow colour. It contains the anti-inflammatory compound
curcumin, that could help to relieve a painful back. Try taking
up to 1,000mg of turmeric supplements everyday to reduce pain.
“Turmeric contains curcumin, which is the active ingredient that
has powerful anti-inflammatory abilities, anti-aging effects and
reduces pain.”
Eating Curry May Improve Memory and Happiness, New
Study Says
Newsweek, March 2018
The
study was also double-blind, which means neither the doctor nor
patient knew whether they were taking a placebo or the curcumin
supplement. The participants received cognitive tests at the
beginning of the study every six months and blood tests that
monitored their curcumin levels. Memory improved by 28 percent
over the course of 18 months among participants taking curcumin.
There were mild improvements in mood, too, and brain scans
revealed fewer signs of amyloid and tau, which are two abnormal
proteins that form clumps in the brains of patients with
Alzheimer's disease.
The secret behind Julianne Hough's white teeth is
common household spice turmeric
Business
Insider, March 2018
Turmeric has a key component called
curcumin, which is a natural anti-inflammatory that clears
bacteria. Turmeric itself has been around for a very long time.
It’s the spice that gives curry its color and Indians have been
using it as a cooking aid and medicinal herb for thousands of
years. What makes it so beneficial to our bodies is its key
component: curcumin, which is a natural anti-inflammatory that
repairs damage and clears away bacteria.
Curcumin prevents strokes in stroke-prone spontaneously
hypertensive rats by improving vascular endothelial function
BMC
Cardiovascular Disorders, March 2018
Administration of
curcumin significantly delayed the onset of stroke and increased
the survival of SHRsp, which was ascribed to decreased ROS and
improved endothelial dependent relaxation of carotid arteries.
In the presence of UCP2 inhibitor genipin, both
curcumin-mediated decrease of ROS and increase of NO production
were blocked. Our study suggests that curcumin exerts a stroke
preventive effect by attenuating oxidative stress to improve
vascular endothelial function, which might be associated with
UCP2 signaling.
Curcumin shows promise for treating Gulf War illness
Tamhsc.edu, March 2018
Turmeric, a spice commonly found in
curry, has long been touted for its health benefits. Now,
evidence in animal models suggests that one of its components,
called curcumin, may be able to reverse some of the effects of
Gulf War illness (GWI), according to recent research published
in the journal Brain, Behavior, and Immunity. This research was
funded by the Department of Veterans Affairs and the Department
of Defense.
Reasons why turmeric is scientifically good for you
TV3, March 2018
Researchers have found that
curcumin, the bright yellow chemical produced by turmeric, is
capable of interacting with a variety of molecules involved in
inflammation, easing swelling, aches and pains in the joints and
muscles. In fact, a study published in the National Center for
Biotechnology Information found that cucurmin may be just as
effective as aspirin and ibuprofen at suppressing the body’s
inflammatory response. As well as bolstering the body’s natural
antioxidant function by increasing glutathione levels, studies
have found curcumin’s molecular structure can even neutralise
harmful free radicals in the body, lessening the chances of
disease. One study published in the Nutrition Research journal
in 2012 even found that curcumin may be as effective in
improving vascular function in post-menopausal women as a
moderate exercise routine. Research has shown that curcumin has
a similar effect as antidepressants on patients suffering from
depression, mood swings and anxiety, and studies on mice found
that daily doses of turmeric can even increase the amount of
happy hormones (serotonin and dopamine) in the brain.
Curcumin inhibits superoxide dismutase-induced
epithelial-to-mesenchymal transition via the PI3K/Akt/NF-κB
pathway in pancreatic cancer cells
International Journal of Oncology, March 2018
Curcumin is a
natural polyphenol compound derived from turmeric. It possesses
multiple pharmacological properties, including antioxidant,
anti-inflammatory and anti-tumor progression properties. To
summarize, these results demonstrated that curcumin was able to
prevent SOD-driven H2O2-induced pancreatic cancer metastasis by
blocking the PI3K/Akt/NF-κB signaling pathway. The use of
curcumin to inhibit the H2O2/Akt/NF-κB axis may be a promising
therapeutic approach to the treatment of patients with
pancreatic cancer.
Natural Ways to Help Prevent Alzheimer’s Disease
Care2, March 2018
Research shows that the compound curcumin,
found in the curry spice turmeric, not only protects the brain
against memory loss, it may even help to protect it against
Alzheimer’s disease. Curcumin is the plant nutrient that gives
turmeric its golden-yellow hue. It turns out this vibrant
compound also holds tremendous promise against serious brain
disease by preventing the formation of beta amyloid plaques,
which are involved in Alzheimer’s. Alzheimer’s patients with
severe symptoms, including dementia, irritability, agitation,
anxiety and apathy, have shown excellent therapeutic results
when taking curcumin, according to a study published in the
Japanese medical journal Ayu.
Curry ingredient more effective than paracetamol at
easing painful injuries
Guardian, March
2018 Turmeric is more effective than popular painkillers at
easing the agony of sports injuries, new research suggests.
After less than three weeks, taking a key component of the
Indian staple spice, known as curcumin, eases injured rugby
players’ discomfort just as much paracetamol or ibuprofen, but
without their side effects, a study found. Those opting for
medication over the curry ingredient are four times more likely
to suffer gastro-related complications, the research adds. This
study suggests the naturally-derived, curcumin-based product
could represent a promising safe, analgesic remedy in painful
osteo-muscular conditions associated with intense, high impact,
physical activities.
Turmeric is more effective than paracetamol or
ibuprofen at healing injuries
Deccan Chronicle, March 2018
A new study now suggests
that turmeric is more effective than popular painkillers at
easing the agony of sports injuries. The study found that after
less than three weeks, taking a key component of the Indian
staple spice, known as curcumin, eases injured rugby players'
discomfort just as much paracetamol or ibuprofen, but without
their side effects.. The researchers further believe that
curcumin may also benefit sufferers of inflammatory conditions,
such as arthritis patients, without causing the complications
associated with many existing treatments. Results further reveal
those taking curcumin are more likely to stick to their
treatment regimen. The researchers analysed 50 rugby players
from the Italian premier Piacenza club south of Milan who were
suffering bone or muscle problems as a result of incidents, such
as repeated tackling. Half of the study's participants were
given the one gram curcumin-extract tablet Algocur, which is
known as Turmeric+ in the UK, twice a day for up to 10 days. The
remainder took painkillers. The findings were published in the
European Review for Medical and Pharmacological Sciences
journal. This comes after research released last month suggested
turmeric may boost people's memories by nearly 30 per cent, as
well as easing depression. Taking curcumin causes people to have
significantly less protein build-up in the regions of the brain
associated with memory and emotion, a study found. Past studies
have also linked the onset of Alzheimer's disease to the
accumulation of protein plaques in the brain. Curcumin, which
gives turmeric its yellow color, is thought to improve memory
and boost mental health due to its anti-inflammatory properties.
Inflammation has previously been linked to both dementia and
severe depression.
Curry ingredient turmeric is MORE effective than
paracetamol or ibuprofen at easing painful injuries, study finds
Daily Mail, March 2018
Indian spice staple eases discomfort
just as much as paracetamol or ibuprofen. Yet its key component
curcumin does not cause their gastro side effects. Curcumin is a
safe alternative to drugs after intense, high-impact exercise.
Inflammatory-condition sufferers, like arthritis patients, may
also benefit. Curcumin has been used as a herbal remedy in
arthritis and heart disease.
Curcumin differentially affects cell cycle and cell
death in acute and chronic myeloid leukemia cells
Oncology Letters, March 2018
Curcumin is a phytochemical with
potent anti-neoplastic properties. The antitumoral effects of
curcumin in cells derived from chronic or acute myeloid leukemia
have been already described. In conclusion, curcumin elicits
different cellular mechanisms in chronic or acute myeloid
leukemia cells and the powerful antitumoral effect was more
potent in K562 compared with HL-60 cells.
Herbal cures for uterine fibroids
Guardian, March 2018
The results showed the mean diameter of
leiomyoma were statistically different at before and after three
and six month’s curcumin intake. And both mean volume of
leiomyoma was statistically different at before and after three
and six month’s curcumin intake. Adverse effect of curcumin was
not found. Also, Egyptian researchers have successfully used
turmeric, in clinical studies, to decrease the volume of uterine
fibroids in women. The study published in Journal of American
Science is titled “Curcumin a New Modality for Treatment of
Uterine Myoma.” The results of the study found statistically
significant decrease in the uterine volume and myoma volume
(cm3), “again we find statistically significant increases in Hb
percentage after treatment the bleeding stop completely in 88
per cent after two weeks treatment and after four weeks in 12
per cent of the cases.” The researchers concluded: “Curcumin is
a new drug with multiple pharmacological actions, no reported
side effects of significances for treatment of myoma.” Also,
another study published in Gynecological Endocrinology showed
curcumin suppressing fibroid cell replication by interacting
with Peroxisome Proliferator-Activated Receptor-Gamma (PPARg).
PPARg is a cell receptor that plays a role in controlling the
cell cycle and cell division. It also has been found to suppress
inflammation.
Nutritionist Says Everyone Over 30 Should Be on
These Supplements
New Beauty, March 2018 “I love CoQ10 and a
curcumin—they're both antioxidants, so they work great if you’re
looking to anti-age,” LeVeque says. “CoQ10 is known to help
mitochondrial health and boost cellular energy, and as we age,
you want to keep your mitochondria working efficiently because
they're the energy powerhouse inside every cell in your body.”
Additionally, coQ10 can protect skin against environmental
stressors and free radicals, deterring any damage that can
accelerate the aging process. “Curcumin—another good option—is
the active ingredient inside turmeric and super
anti-inflammatory,” adds LeVeque. Furthermore, curcumin has been
proven to have a few under-the-radar health perks; most notably
that it might be able to reduce the risk of Alzheimer’s.
Know the various health benefits of everyday spices
and herbs
Review Online, March 2018
Turmeric. This yellow spice gets a lot of hype, and for good
reason. It’s a good source of curcumin, an antioxidant that
eases inflammation. Research suggests curcumin may help ease
pain and lower the chances of heart attacks. Other research
shows eating even small amounts of turmeric regularly may help
prevent or slow down Alzheimer’s disease, possibly by helping
prevent the brain plaques that lead to dementia.
Curcumin induces apoptosis and inhibits proliferation in
infantile hemangioma endothelial cells
Medicine, March 2018
Curcumin has been used as an alternative
medicine for the treatment of infantile hemangiomas (IHs). We
found that curcumin potently inhibited proliferation in HemECs,
achieving low-micromolar IC50 (the half maximal inhibitory
concentration) value. We also observed that treatment with
curcumin induced apoptosis in HemECs, as evidenced by positively
Annexin-V-FITC staining, caspase-3 activation, and cleavage of
poly(adenosine diphosphate-ribose) polymerase (PARP) in the
treated cells. Moreover, we showed that curcumin suppressed the
expression of antiapoptotic protein myeloid cell leukemia-1
(MCL-1), hypoxia-inducible factor 1α (HIF-1α), and vascular
endothelial growth factor (VEGF).Altogether, our study suggests
that the effectiveness of curcumin in IHs may be associated with
its potent antiproliferative and apoptotic activities in HemECs.
Turmeric Can Help Prevent Heart Attacks, Doctor Says
Tech Times, March 2018
"The main active ingredient in
turmeric is curcumin and it's used as an antioxidant,
anti-inflammatory and has some action as an antiplatelet agent
that can slow blood clotting, in a similar but more gentle way
than aspirin," said Cotterel. Aspirin has also been used to help
prevent heart attacks. Dr. Cotterel expressed turmeric can be
used similarly, although there are no clinical trials to back up
this up other than in people who have just gotten coronary
artery bypass grafts. "Clinical research suggests that taking
the turmeric constituent, curcuminoids, 4 grams daily beginning
3 days prior to surgery and continuing for 5 days post-surgery
can decrease the relative risk of myocardial infarction
following coronary artery bypass grafting by approximately 56
percent compared to placebo," according to the Natural Medicines
Database. Turmeric's anti-inflammatory effects can help reduce
joint pain, osteoarthritis, and may help pain related to
rheumatoid arthritis. "Curcumin is another great way to get a
higher dose of it so if used therapeutically, it's best to do
for arthritis. You wouldn't overdose on it," said Dr. Cotterel.
"Since it is an antioxidant, the spice can be sometimes used to
help prevent some of the diseases associated with oxidation in
the body such as cancer. It has also been found to be effective
in itching from various sources," said Dr. Cotterel. In
addition, other research suggests taking turmeric extract at 1.4
grams/day orally in two different doses over 3 months have the
ability to reduce levels of total cholesterol, low-density
lipoprotein (LDL) cholesterol, very low-density lipoprotein
(VLDL) cholesterol, and triglyceride in patients aged 15-45
years-old.
Curcumin may serve an anticancer role in human
osteosarcoma cell line U-2 OS by targeting ITPR1
Oncology Letters, March 2018
Treatment with curcumin was able
to significantly increase the levels of CLTC and ITPR1 mRNA in
curcumin‑treated cells compared with control. In addition,
targeting ITPR1 with curcumin significantly promoted apoptosis
and suppressed proliferation, migration and invasion. Targeting
ITPR1 via curcumin may serve an anticancer role by mediating
apoptosis, proliferation, migration and invasion in U-2 OS
cells.
Turmeric Could Help Treat Endometriosis, Says Study
Womens Health, March 2018
A review of relevant studies
published in the journal Biomedicine & Pharmacotherapy, examined
the effect that curcumin, a compound found in turmeric, has on
the disease. Results of in vitro and animal studies showed that
curcumin reduced pain and inflammation through the suppression
of inflammatory cytokines expression. It was also found to
repress the invasion, attachment, and angiogenesis of
endometrial lesions, inhibiting the disease's progression.
Curcumin and endometriosis: Review on potential
roles and molecular mechanisms
Science
Direct, March 2018
Turmeric, an important spice all around
the world, is obtained from the rhizomes of Curcuma longa, a
member of the Zingiberaceae family. It has been used in the
prevention and treatment of many diseases since ancient times.
Curcumin is the principal polyphenol isolated from turmeric.
Several evidences have shown the anti-inflammatory, antioxidant,
anti-tumor, anti-angiogenesis, and anti-metastatic activities of
curcumin. In this review, relevant articles on the effect of
curcumin on endometriosis and possible molecular mechanisms are
discussed. The results of related in vitro and animal studies
have shown that treatment with curcumin reduces inflammation
through suppression of inflammatory cytokines expression. It
also can inhibit invasion, attachment, and angiogenesis of
endometrial lesions. Moreover, curcumin inhibits cell
proliferation and causes cell cycle arrest and apoptosis. Thus,
it may has potential benefits as a dietary and pharmacological
agent for the prevention and treatment of endometriosis.
Turmeric is great, but look for curcumin
Herald Dispatch, March 2018
Finding a high-potency curcumin
supplement can unfortunately be tougher than it sounds. Curcumin
only occurs at a pretty low percentage in standard turmeric
powder, somewhere roughly between 2 to 4 percent by weight. Many
products on the market will claim to be "turmeric with
curcumin." That sounds great, but doesn't really mean much,
being that all turmeric contains curcumin. Instead of a somewhat
vague label claim, pay attention to the supplement facts panel
to see what percentage of curcumin is guaranteed per serving.
The most-studied curcumin products on the market can range
anywhere from 30 to 95 percent curcumin. It is also a pretty
common trick to see a product claiming "made with 95 percent
curcumin" on the front of the bottle, but after a glance at the
supplement facts, it may only use a small amount of that
curcumin extract in a base of regular turmeric powder. The
high-potency extraction process takes a lot of raw material,
therefore quality supplements can be a little on the expensive
side. In certain curcumin supplements, one capsule can equal the
absorption of up to 500 regular turmeric powder capsules, so it
can be worth the extra price for the extra potency.
Curcumin inhibits hepatocellular carcinoma growth by
targeting VEGF expression
Oncology Letters,
March 2018
Curcumin is a polyphenol compound that has been
demonstrated to exert effective antiangiogenic,
anti‑inflammatory, antioxidant, and antitumor effects. Curcumin
treatment inhibited H22 cell proliferation and promoted H22 cell
apoptosis in a dose‑dependent manner in vitro. In addition,
curcumin treatment inhibited tumor growth in vivo at the
concentrations of 50 and 100 mg/kg. Furthermore, curcumin
treatment significantly decreased VEGF expression and PI3K/AKT
signaling. The present findings demonstrated that curcumin
inhibited HCC proliferation in vitro and in vivo by reducing
VEGF expression.
Turmeric helps eliminate depression, alleviate pain,
slow the aging process, protect the digestive tract, and prevent
cancer
Pulse, March 2018
As a matter of
fact, a number of laboratory studies on cancer cells have shown
that curcumin, which is the principal curcuminoid of turmeric,
does have anticancer effects. It has been observed to have the
ability to kill cancer cells as well preventing more from
growing. In addition, turmeric also has the best effects on
breast cancer, bowel cancer, and stomach cancer and skin cancer
cells. And curcumin, which is the principal curcuminoid of
turmeric, happens to be a potent antioxidant that neutralizes
free radicals due to its chemical structure as well as boosting
the activity of the body's own antioxidant enzymes.
Study backs daily consumption of curcumin for your
memory, mood
Jakarta Post, March 2018
The research study involved 40 adults aged between 50 and 90
years old who experience "mild memory complaints." They were
randomly given "either a placebo or 90 mg of curcumin" twice a
day. After 18 months, those who consumed curcumin were reported
to experience "significant improvements in their memory and
attention abilities," while those who were given the placebo did
not. In addition to a 28 percent increase in their memory, the
curcumin group were also found to enjoy "mild improvements in
mood." “These results suggest that taking this relatively safe
form of curcumin could provide meaningful cognitive benefits
over the years,” said Small.
Turmeric and Curcumin
Pop Sugar, March 2018
Curcumin is the most active ingredient
in turmeric. It's the chemical compound that naturally occurs in
turmeric. Curcumin makes up 2 percent to 6 percent of the
turmeric spice found in your cabinet, according to Andrew Weil,
MD. In fact, curcumin gives turmeric its distinct yellow color.
That color is passed on to curry, since turmeric is a main
ingredient in that spice. But curcumin isn't just part of
spices; it has powerful health benefits all its own, such as
being an antioxidant and having antitumor properties. In
addition, at least one study has found that curcumin can be
effective as a treatment for depression. Even more recently, a
2018 study from UCLA found that curcumin can help improve mood
and memory loss. ADVERTISEMENT This is a modal window. The media
could not be loaded, either because the server or network failed
or because the format is not supported. Just like turmeric,
curcumin also has anti-inflammatory properties, making it a
viable way to ease arthritis pain and discomfort. It also can
ease muscle soreness after a workout, help you sleep better, and
combat bloating. If those aren't enough benefits for you, in an
animal study, curcumin was shown to prevent fat tissue growth.
There's also a parallel between curcumin and the prevention of
cardiovascular diseases, diabetes management, and protection
from cancer, and it can be used as a therapeutic aid with
gastrointestinal issues, like ulcerative colitis.
Turmeric could improve memory
The Chronicle Herald, March 2018
A new study published late
January in the American Journal of Geriatric Psychiatry
investigated the effect of a highly-absorbable curcumin
supplement on the memory of healthy people with mild memory
complaints. This study also examined the effect of this curcumin
supplement on the plaques and tangles which form in the brains
of people with Alzheimer’s disease. This study was small with
just 40 subjects between the ages of 50 to 90 years old. All
study participants were randomly given either daily placebo or a
highly- absorbable curcumin supplement over the course of the
18-month study. By the end of the 18-month study, the people who
took the curcumin supplement were found to have improved memory
and mood compared to those who took the placebo. The memory
tests administered by the researchers at the study’s end showed
a 28 per cent improvement in those taking the curcumin
supplement, compared to those taking placebo. Additionally,
Positron emission tomography (PET) brain scans performed at the
end of the study showed a significant reduction in amyloid and
tau signals in the amygdala and hypothalamus of the participants
who took the curcumin supplement, compared to those who took the
placebo. These two markers are important indicators of brain
health and risk of developing Alzheimer’s.
What does the evidence say about turmeric's health
benefits?
ABC, March 2018
It's not the
spice itself that's key, rather it's an active compound within
turmeric called curcumin. Research has found that curcumin has
some anti-oxidant and anti-inflammatory properties. "Curcumin is
a very powerful anti-inflammatory agent," said Professor Manohar
Garg, director of the nutraceuticals research program at the
University of Newcastle. Because inflammation is linked to a
range of chronic conditions and diseases, among them arthritis,
Alzheimer's and heart disease, researchers argue curcumin could
help reduce the risk of those diseases by limiting inflammation
in the body. "It's very powerful, the most powerful food I know
of, for fighting inflammation in the body," Professor Garg said.
Research conducted by the professor and his team found those
people taking a combination of curcumin and a phytosterol (a
naturally occurring steroid found in plants) reduced their
cholesterol levels over a four-week period compared to a group
who received a placebo. "There's some cholesterol-lowering
effect from curcumin, and some cholesterol-lowering effect from
phytosterols, but if you combine them together it's a
synergistic effect. It's beyond what you expect from the two
compounds separately," Professor Garg said. Other research into
curcumin has focused on its potential to improve cognitive
function, particularly in older people. The researchers found
those in the group given curcumin supplements had better working
memory and an improved mood while taking the cognitive tests
over a 28-day period. Professor Scholey said it was possible the
curcumin was improving blood flow to the brain in those who took
the supplements. "There is some work showing that curcumin can
improve what's called endothelial function — that refers to the
cells that line blood vessels, which can be in various degrees
of elasticity or stiffness," Professor Scholey said.
Curcumin May Reverse Memory Problems, Improve Mood
Forbes, March 2018
Memory function of those who’d taken
curcumin improved by 28% on average over the 18 months. In
contrast, the control group's scores rose slightly (possibly
because they got more familiar with the tests) and then
declined. The depression scores of those taking curcumin also
improved; the control group's didn't change. And interestingly,
brain scans revealed significantly less amyloid and tau
accumulation in two brain regions of the participants taking
curcumin—the amygdala and hypothalamus, which control anxiety,
memory, decision-making, and emotion.
Best Foods That Could Calm The Symptoms Of Acid
Reflux
Inquisitr, March 2018
Turmeric
contains anti-inflammatory and antioxidant properties. It also
has curcumin, which is its most active ingredient. It is known
that curcumin has antibacterial and anticancer properties. In a
2007 study, it indicated that GERD should be treated with
antioxidants and anti-inflammatories. In another study, it
suggested that curcumin with its anti-inflammatory effects could
prevent esophageal inflammation.
Indian spice may help improve memory
WNYT, March 2018
The spice turmeric, commonly used in Indian
food, may help to improve memory. It's actually a compound
within the spice called curcumin. Researchers at UCLA looked at
40 older adults with mild memory problems. Patients who took
curcumin tablets for 18 months scored higher on memory tests and
had fewer brain plaques than those who took a placebo. The
curcumin group also reported small improvements in mood. Experts
believe curcumin may reduce brain inflammation, which has been
linked to Alzheimer's disease and depression.
New Study Shows Turmeric May Improve Brain Health
Cooking Light, March 2018
Curcumin, the bright yellow
polyphenol compound found in turmeric, has been the focus of
research due to its potential to prevent chronic diseases such
as cancer, heart disease, arthritis, diabetes, and Alzheimer’s
disease. Clinical studies support curcumin’s anti-inflammatory
and antioxidant effects on obesity and associated inflammation,
leading to outcomes such as weight loss, improved blood lipids,
reduced risk of atherosclerosis, and improved insulin
sensitivity. Daily consumption of curcumin has been shown to
improve memory and mood in people with mild, age-related memory
loss, according to a study by UCLA that was recently published
in the American Journal of Geriatric Psychiatry. Researchers
examined the effects of curcumin supplements in people ages
51-84 who had mild memory complaints, but no dementia, as well
as those ages 51-84 who were diagnosed with Alzheimer's disease.
Participants took either a placebo or 90 milligrams of curcumin
two times a day for 18 months. At the end of the experiment, PET
scans determined those who took curcumin experienced significant
improvement in their memory, mood, attention span, while those
who took the placebo did not experience any of these positive
effects. Researchers have identified chronic infections and
inflammation as major risk factors for various types of cancer.
As such, regular consumption of turmeric has been touted as a
possible contributor to lower cancer rates. Results from several
studies suggest that curcumin may reduce tumor promotion, block
cell transformation, and minimize the spread of certain types of
cancer. Curcumin’s role in the treatment of arthritis also shows
promise. Studies show that patients supplementing with curcumin
had reduced arthritis pain and swelling due to the inhibition of
COX-2 activity. This is typically what NSAIDs are prescribed
for.
Curcumin and derivatives function through protein
phosphatase 2A and presenilin orthologues
Biologists.org March 2018
Curcumin, the main curcuminoid of
turmeric, is a complex molecule possessing wide-ranging
biological activities, cellular mechanisms and roles in
potential therapeutic treatment, including Alzheimer's disease
and cancer. Here, we investigate the physiological effects and
molecular targets of curcumin in Dictyostelium discoideum. We
show that curcumin exerts acute effects on cell behaviour,
reduces cell growth and slows multicellular development. Using
in silico docking analysis, we then showed that curcumin might
function through direct binding to a key regulatory region of
PsrA. These findings reveal novel cellular and molecular
mechanisms for the function of curcumin and related compounds.
Is Turmeric Good For You? Science Says It Can
Improve Your Memory, So Eat Up
Elite Daily,
March 2018
Curcumin and turmeric are sometimes
used interchangeably, but they actually aren’t the same thing.
Turmeric is a spice, while curcumin is a chemical compound that
is found in turmeric. In other words, curcumin can be taken
separately from turmeric in supplement form, but turmeric
doesn’t exist without curcumin. For example, in addition to
improving memory, turmeric yields a decent amount of medicinal
properties. According to Healthline, curcumin is also a strong
antioxidant and contains anti-inflammatory properties. It also
has been noted to potentially prevent heart disease by
strengthening blood vessel lining.
Curcumin May Help Improve Memory: Other Potential
Health Benefits Of This Turmeric Compound
Tech Times, March 2018
The researchers found less signals of
tau and amyloid proteins in those who were given curcumin
supplements. These proteins are linked to the development of
Alzheimer's Disease. "Exactly how curcumin may exert cognitive
and mood effects is not certain, but several potential
mechanisms could explain our findings," researchers wrote in
their study. "Curcumin reduces inflammation, and heightened
brain inflammation has been linked to both Alzheimer disease and
major depression." Countries such as India, where people eat
curcumin at levels of about 100 mg to 200 mg a day over long
periods of time, have low prevalence of cancer. Researchers
suspect this may have something to do with the health benefits
of turmeric. Earlier studies have shown other possible
beneficial effects of consuming curcumin on health. In a 2001
study involving patients with precancerous changes,
investigators found that curcumin could stop precancerous
changes in organs from developing into cancer. "Our results also
suggest a biologic effect of curcumin in the chemoprevention of
cancer," the researchers wrote in their study. Lab tests also
showed that turmeric extract that contains curcumin may help
stabilize colorectal cancer that did not benefit from other
forms of treatment.
Study says Increase your memory and mood by eating
turmeric
Week Facts, March 2018
Found in
turmeric, curcumin is hailed as a mitigating with cancer
prevention agent properties, and it has additionally been
recommended as a conceivable reason that senior residents in
India – where curcumin is to some degree a staple – have bring
down rates of Alzheimer’s malady and better psychological
execution. The examination directed by the University of
California Los Angeles set out to inspect the impacts of the
fixing on individuals with mellow, age-related memory
misfortune. “Precisely how curcumin applies its belongings isn’t
sure, however it might be because of its capacity to lessen mind
aggravation, which has been connected to both Alzheimer’s
ailment and real sorrow,” said Dr. Gary Small.
Is Turmeric an Effective Treatment for
Endometriosis?
Medical
News Bulletin, March 2018
The spice turmeric, which contains
the polyphenol curcumin, has long been thought to contain
antioxidant and strong anti-inflammatory properties. However,
few studies have investigated the effects of curcumin on
endometriosis. In a recent study published in Biomedicine &
Pharmacotherapy, researchers from Iran reviewed the effects.
Studies Show Curcumin as Generally Safe and Effective The
limited in-vitro and animal studies indicate that curcumin can
reduce inflammation by suppressing inflammatory cytokine
expression. In addition, there is some evidence that curcumin
may reduce the disease progression by inhibiting the invasion,
attachment, and angiogenesis of endometrial lesions. Curcumin is
generally recognized as safe to use by the US Food and Drug
Administration, and studies have demonstrated its safety up to
at least 15 mg per day.
Dietary Curcumin Intervention Targets Mouse White
Adipose Tissue Inflammation and Brown Adipose Tissue UCP1
Expression
Obesity, March 2018
Curcumin
intervention reduced WAT macrophage infiltration and altered
macrophage functional polarity, as the ratio of M2-like versus
M1-like macrophages increased after curcumin intervention.
Curcumin treatment reduced M1-like macrophage markers or
proinflammation cytokine expression in both macrophages and
adipocytes. Curcumin intervention also increased energy
expenditure and body temperature in response to a cold
challenge. Finally, the in vivo and in vitro investigations
suggested that curcumin increased expression of uncoupling
protein 1 (UCP1), possibly involving PPAR-dependent and
-independent mechanisms. Curcumin intervention targets both WAT
inflammation and BAT UCP1 expression. These observations
advanced our knowledge on the metabolic beneficial effects of
the curry compound curcumin, bringing us a novel perspective on
dietary polyphenol research.
Molecular targets of Curcumin
Advances in Experimental Medicine and Biology, March 2018
Curcumin possesses anti-inflammatory activity and is a potent
inhibitor of reactive-oxygen-generating enzymes such as
lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase, and
inducible nitric oxide synthase (iNOS); it is an effective
inducer of heme oxygenase-1. t has been demonstrated that
curcumin- induced apoptosis is mediated through the impairment
of the ubiquitin–proteasome pathway.
Curcumin attenuates heat-stress-induced oxidant
damage by simultaneous activation of GSH-related antioxidant
enzymes
Academic.oup.com, March 2018
It
was concluded that curcumin supplementation enhanced the
resistance of broilers to heat stress, as evidenced by reversing
the FC, increasing the GSH content and GSH-related enzyme
activities, and inducing the expression of Nrf2 and
Nrf2-mediated phase II detoxifying enzyme genes.
Dietary curcumin may boost egg quality, hen health
Feed
Navigator.com, March 2018
We can conclude that curcumin added
in the diet of laying hens was able to increase egg antioxidant
levels, as well as to reduce lipid peroxidation in fresh and
stored eggs, contributing to the improvement of egg quality.
Moreover, the curcumin exerted beneficial effects on an animal
health by stimulating the immune response and controlling
coccidiosis.
Dietary curcumin may boost fish survival,
performance
Feed
Navigator.com, March 2018
Our results demonstrated that
curcumin dietary supplement exerts potent bactericidal action
against S. agalactiae, presenting 100% of therapeutic efficacy
when compared to infected and non-supplemented animals. Also,
the treatment prevented the occurrence of clinical signs of
disease.
The Surprising Health Benefit Hiding In Turmeric,
The bright yellow spice may help protect your brain, a new study
finds
Mens Health, February 2018
At the
end of the study, the curcumin group experienced a 28 percent
improvement in their memory tests, while those popping the
placebo didn’t see a significant change. What’s more, they also
saw a slight boost in their mood compared to the placebo
poppers. The researchers can’t say exactly why curcumin might
have these effects. But after analyzing the brain scans, they
noticed that people taking curcumin had lower levels of both
abnormal proteins, specifically in areas of the brain that
influence memory and emotion. Plus, curcumin is an antioxidant
that might fight inflammation, explains study author Gary W.
Small, M.D., director of the UCLA Longevity Center. The more
inflammation you have in your brain, the more likely you are to
experience cognitive problems and depression, he says.
Curcumin May Reverse
Memory Problems, Improve Mood
Forbes, February 2018
With more and more
of the aging population affected by Alzheimer's disease, and
clinical trials for new medications often providing
underwhelming results, a new study in The American Journal of
Geriatric Psychiatry may be especially promising. It finds that
taking a daily dose of curcumin, the compound in turmeric root
that gives curry its yellow color, may not only prevent memory
problems from worsening over time, but actually improve them.
And perhaps most noteworthy, these changes were seen not only in
the participants' cognitive capacities, but also in their brain
cells. It turned out that the memory function of those who’d
taken curcumin improved by 28% on average over the 18 months. In
contrast, the control group's scores rose slightly (possibly
because they got more familiar with the tests) and then
declined. The depression scores of those taking curcumin also
improved; the control group's didn't change. And interestingly,
brain scans revealed significantly less amyloid and tau
accumulation in two brain regions of the participants taking
curcumin—the amygdala and hypothalamus, which control anxiety,
memory, decision-making, and emotion.
Is Turmeric Beneficial to Everyone? Dr. David Samadi
Explains.
Reporter Expert, February
2018 Renowned surgeon David Samadi is enthusiastic about
people using turmeric to improve their own health. Dr. Samadi is
the chairman of urology and the chief of robotic surgery at New
York City’s Lenox Hill Hospital. He is a world leader in using
cutting-edge technology to treat cancer patients. At the same
time, he is passionate about educating people about what they
can do for themselves to live a healthy and vibrant life. To
that end, he makes frequent appearances in the media to spread
his knowledge to as many people as possible. Dr. Samadi is a
member of the Medical A-Team on Fox News and is the chief
medical correspondent on AM 970, a popular radio station serving
the New York City metropolitan area. According to Dr. Samadi,
turmeric may be helpful in treating or preventing arthritis,
inflammatory bowel disease, Alzheimer’s disease, cancer and
depression. He explains the science behind turmeric’s beneficial
effects in treating the following common conditions: Arthritis
Studies show that curcumin, the active ingredient in turmeric
that has anti-inflammatory properties, can help relieve the pain
caused by joint inflammation. Inflammatory Bowel Disease Studies
show that curcumin lowers the rate of relapse for people
suffering from ulcerative colitis, which is a chronic form of
inflammatory bowel disease. Alzheimer’s Disease Research shows
promising results in using turmeric to help slow down the
progression of this terrible disease. Scientists believe that
curcumin may help destroy the plaque that causes Alzheimer’s
patients to lose cognitive function. Countries where turmeric is
frequently used in cooking have lower rates of Alzheimer’s
disease. Cancer Research shows that curcumin may help reduce the
spread of tumors in patients who have pancreatic and some other
types of cancer. It is not a stand-alone treatment, but it may
be useful as a supplement to other forms of treatment.
Depression Several studies have shown that curcumin can help
reduce the symptoms of depression. How to Use Turmeric for Your
Health If you are not used to cooking with turmeric, you may
wonder how to incorporate it into your daily life. You can buy
turmeric as a whole root or in dried and powdered form. Both are
good, but the dried form has a higher concentration of curcumin,
the component of turmeric most often studied for its
anti-inflammatory health benefits. Dr. David Samadi points out
that a standard dosage of turmeric hasn’t been established.
However, he suggests that one to three grams per day of the
dried form of turmeric is probably enough. How to Maximize the
Absorption of Curcumin Dr. Samadi suggests that you consume
turmeric when you are eating a meal. Taking turmeric with food
helps your body better absorb the curcumin in the turmeric. You
can help ensure you are absorbing the maximum amount by
ingesting turmeric while you are eating a meal that contains
healthy fats. These fats include fish oil, olive oil, avocado
oil, coconut oil, nuts and seeds.
Turmeric Compound Boosts Cognitive Power, Reveals
New Study
Sci-News, February 2018
Curcumin has previously been shown to have anti-inflammatory and
antioxidant properties in lab studies. It also has been
suggested as a possible reason that senior citizens in India,
where curcumin is a dietary staple, have a lower prevalence of
Alzheimer’s disease and better cognitive performance. “The
people who took curcumin experienced significant improvements in
their memory and attention abilities, while the subjects who
received placebo did not,” Dr. Small said. “In memory tests, the
people taking curcumin improved by 28% over the 18 months. Those
taking curcumin also had mild improvements in mood, and their
brain PET scans showed significantly less amyloid and tau
signals in the amygdala and hypothalamus than those who took
placebos.”
Curcumin limits weight gain.
Journal of
Applied Physiology, February 2018
We investigated the
effect of curcumin, a naturally occurring polyphenol known for
its anti-inflammatory properties and inhibitory action on
11β-HSD1 activity, on preserving metabolic health and limiting
adipose tissue growth following the cessation of daily exercise
and caloric restriction (CR). Cessation of daily CR and exercise
caused an increase in body mass, as well as a 9- to 14-fold
increase in epididymal, perirenal, and inguinal adipose tissue
mass, all of which were attenuated by curcumin ( P < 0.05).
Insulin area under the curve (AUC) during an oral glucose
tolerance test, HOMA-IR, and C-reactive protein (CRP) were
elevated 6-, 9-, and 2-fold, respectively, in the Detrained +
Placebo group vs. the Trained group (all P < 0.05). Curcumin
reduced insulin AUC, HOMA-IR, and CRP vs. the placebo group (all
P < 0.05). Our results indicate that curcumin has a protective
effect against weight regain and impaired metabolic control
following a successful period of weight loss through diet and
exercise, perhaps via inhibition of glucocorticoid action and
inflammation.
Lowering your risk of Alzheimer's disease
Express, February 2018
Memory loss could also be
prevented by eating more curry, scientists have claimed. The
spice curcumin - which gives curry its bright colour - could
boost patients' mood and memory. Eating curcumin everyday for 18
months improved memory by 28 per cent, a study claimed.
Natural supplements that you should be taking every
day
Blasting News, February 2018
Turmeric -- The spice that gives curry that yellow coloring.
This powerful herb's main ingredient is curcumin, a natural
anti-inflammatory which the body needs to fight off bacteria
that are harmful. Along with the increased production of
antioxidants and a great way to fight heart disease, another
important benefit of taking Turmeric is the growth hormone
called Brain-Derived Neurotrophic Factor. According to the US
National Library of Medicine, decreased levels of BDNF can lead
to brain disease and decreased functions in the brain. Curcumin
can increase levels of BDNF, which can delay or even reverse
many brain diseases or age-related decreases in brain function.
You will want to add this to your supplement routine, as
curcumin makes up only three percent of Turmeric, so taking it
as a supplement is better.
Curcumin Improves Mood and Memory
Doctor Oz, February 2018
UCLA researchers find
consumption of curcumin helps mood and memory. Forty adults with
mild memory complaints were randomly selected to ingest curcumin
twice daily or a placebo for 18 months. They underwent cognitive
assessments and PET scans to test amyloid in the brain, which is
associated with negative effects on memory and emotional
functions. Those taking curcumin improved their memory tests by
twenty-eight percent, demonstrated mild mood improvements, and
showed far smaller levels of amyloid than the placebo group. A
follow-up study will explore the possibility of curcumin
possessing antidepressant effects and whether it can help your
genetic risk for Alzheimer’s. These findings back up the far
lower rate of Alzheimer’s in India’s senior citizens, whose diet
is high in curcumin.
Curry Ingredient May Improve Memory
GKMan, February 2018
Participants who took curcumin
experienced significant improvements in their memory and
attention abilities, while the subjects who received placebo did
not. Therefore it has been proven that curcumin can contribute
to the improvement of memory and disposition of people suffering
from moderate memory loss cause by aging. A new study has been
published, confirming that curcumin, the chemical that gives
curry its intense yellow color, has important health benefits,
in the context of long-term consumption.
The healing power of turmeric: Curcumin may lower
Alzheimer’s disease risk by boosting memory and mood
Times Now News, February 2018
Earlier, a report
published in the British Medical Journal Case Reports, noted
that a 57-year-old woman, who was diagnosed with blood cancer in
2007 after complaining of high blood pressure, curcumin helped
her recover from the deadly condition after conventional
medicine failed to work on her body. The report said the woman
started taking 8g of curcumin a day - one of the main compounds
in turmeric - as a last resort after research online. With no
further treatment, over the last five years, doctors said her
cancer had remained stable and her blood counts are within the
normal range with daily curcumin. The findings revealed that
people who took curcumin experienced significant improvements in
their memory and attention abilities, while the subjects who
received placebo did not. Turmeric is one of the most
traditional and versatile of spices used in Indian cooking. It
has been suggested as a possible reason that senior citizens in
India have a lower prevalence of Alzheimer’s and better
cognitive performance.
Curcumin's Anti-Inflammatory Properties Might
Improve Memory, Attention
Ask Men,
February 2018
Turmeric is on a tear right now. In recent
years it’s been connected to everything from healthier skin to
helping control pain and inflammation. But new research suggests
it can also aid with memory and happiness. The paper, published
last week in the American Journal of Geriatric Psychiatry,
examined the effects of an easily absorbed supplement of
curcumin — the substance that gives turmeric its bright orange
colour — on the performance of memory in people without
dementia. The study also looked at curcumin’s potential impact
on the microscopic plaques and tangles that occur in the brains
of those with Alzheimer’s disease. The heavy use of turmeric in
cooking has already been raised as a possible reason for the
lower rates of Alzheimer’s disease and better cognitive
performances among senior citizens in India compared to the rest
of the world. Why? Most likely because of its capacity to reduce
brain inflammation, “which has been linked to both Alzheimer’s
disease and major depression,” said the study’s author, Doctor
Gary Small of UCLA, in a news release. The study involved a
double-blind, placebo-controlled group of 40 adults between ages
50 and 90. They were Alzheimer’s and dementia free, but all
reported mild memory complaints. The participants were randomly
assigned to receive either a placebo or 90 milligrams of
curcumin twice daily for 18 months. They were then monitored at
six month intervals throughout the test using a standardized
cognitive assessment. After 18 months, those who had been taking
curcumin were reporting significant improvements in memory and
attention abilities. On average, their memory tests improved by
a whopping 28%. The curcumin takers also reported a slight
improvement in mood when compared to those on the placebo.
Striking with the Root: Turmeric Curcumin and
Ulcerative Colitis
Care2, February
2018 Despite evidence going back 40 years that the turmeric
spice component curcumin possesses significant anti-inflammatory
activity, it wasn’t until 2005 that it was first tested on
inflammatory bowel disease. Why did it take so long? Well, who’s
going to fund such a study? Big curry? Even without corporate
backing, individual physicians from New York decided to ask the
next five patients with ulcerative colitis who walked through
their office doors to start curcumin supplements. And,
researchers obliged. They took a bunch of people with quiescent
ulcerative colitis and gave them either turmeric curcumin along
with their typical anti-inflammatory drugs, or a placebo and
their drugs. In the placebo group, 8 out of 39 patients
relapsed, meaning their disease flared back up. In the curcumin
group, however, only 2 out of 43 relapsed, significantly fewer.
And, relapse or not, clinically, the placebo group got worse,
while the curcumin group got better. Endoscopically, which is
objectively visualizing the inside of their colons, doctors saw
the same thing: a trend towards worse or better. The results
were stunning: a 5 percent relapse rate in the curcumin group
compared with a 20 percent relapse rate in the conventional care
group. It was such a dramatic difference that the researchers
wondered if it was some kind of fluke. Even though patients were
randomized to each group, perhaps the curcumin group just ended
up being much healthier through some chance coincidence, so
maybe it was some freak occurrence rather than curcumin that
accounted for the results. So, the researchers extended the
study for another six months but put everyone on the placebo to
ensure the initial findings were not some aberration. The
curcumin was stopped to see if that group would then start
relapsing, too—and that’s exactly what happened. Suddenly, they
became just as bad as the original placebo group. The
researchers concluded: “Curcumin seems to be a promising and
safe medication for maintaining remission in patients with
quiescent ulcerative colitis.” Indeed, no side effects were
reported at all. So, “Curry for the cure?” asked an accompanying
editorial in the journal of the Crohn’s and Colitis Foundation
of America. “Can curcumin be added to our list of options with
respect to maintaining remission in ulcerative colitis? What is
noteworthy about this trial is the fact that not only did the
authors demonstrate a statistically significant decrease in
relapse at 6 months, but a statistically significant improvement
in the endoscopic index as well. Equally telling is the fact
that upon withdrawal of curcumin the relapse rate quickly
paralleled that of patients treated initially with placebo,
implying that curcumin was, in fact, exerting some important
biologic effect.” Similarly, a Cochrane review concluded in 2013
that curcumin may be a safe and effective adjunct therapy.
Curcumin Shown to Improve Memory
Whole Foods Magazine, February 2018
Results of the
study are as follows: Memory function of those who’d taken
curcumin improved by 28% on average over the 18 months. In
contrast, the control group’s scores rose slightly (possibly
because they got more familiar with the tests) and then
declined. The depression scores of those taking curcumin also
improved; the control group’s didn’t change. Brain scans
revealed significantly less amyloid and tau accumulation in two
brain regions of the participants taking curcumin — the amygdala
and hypothalamus, which control anxiety, memory,
decision-making, and emotion.
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute
Liver Injury
Molecules, February 2018
Curcumin pre-treatment significantly decreased CCl4-induced
inflammation. Furthermore, curcumin pre-treatment significantly
down-regulated the expression of TGF-β1 and Smad3 mRNAs (both p
< 0.01), and up-regulated the expression of nuclear-factor
erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p <
0.01) in the liver. Inhibition of HO-1 attenuated the protective
effect of curcumin on CCl4-induced acute liver injury. Given
these outcomes, curcumin could protect against CCl4-induced
acute liver injury by inhibiting oxidative stress and
inflammation, which may partly involve the activation of
Nrf2/HO-1 and inhibition of TGF-β1/Smad3 pathways.
Curcumin ‘improves mood and memory
Health Spectator, February 2018
Daily
consumption of curcumin improves the memory and mood of people
with mild, age-related memory loss, according to a new study by
the University of California, Los Angeles. The research, which
has been published the American Journal of Geriatric Psychiatry,
examined the effects of an easily absorbed curcumin supplement
on memory performance in people without dementia, as well as
curcumin’s impact on the microscopic plaques and tangles in the
brains of people with Alzheimer’s. Found in turmeric, curcumin
has previously been shown to have anti-inflammatory and
antioxidant properties in lab studies. It also has been
suggested as a possible reason that senior citizens in India,
where curcumin is a dietary staple, have a lower prevalence of
Alzheimer’s and better cognitive performance. The people who
took curcumin experienced significant improvements in their
memory and attention abilities, while the subjects who received
placebo did not. In memory tests, the people taking curcumin
improved by 28 per cent over the 18 months. Those taking
curcumin also had mild improvements in mood, and their brain PET
scans showed significantly less amyloid and tau signals in the
amygdala and hypothalamus than those who took placebos.
How turmeric can help treat irritable bowel syndrome
(IBS)
The Health Site, February 2018
The active ingredient in the spice, curcumin, has a laundry list
of health benefits. A recent case study in the BMJ showed how a
cancer-stricken 57-year-old woman who was given only a few
months to live cured herself with turmeric. Currently, there is
enough evidence to make a case for turmeric as complementary
therapy also for irritable bowel syndrome or IBS. The beneficial
effects of turmeric on IBS could be attributed to its
anti-inflammatory, antioxidant, antibacterial and spasmolytic
effects. Another 2010 study conducted on animals showed that
curcumin in the turmeric could be beneficial in curbing stomach
disorders such as diarrhoea, cramps and IBS.
How a Nutritionist Uses Turmeric For Health
Pop Sugar, February 2018
Research published in the
journal Oncogene found that turmeric is actually a more
effective anti-inflammatory than over-the-counter pain relievers
like aspirin and ibuprofen. ADVERTISEMENT This is a modal
window. The media could not be loaded, either because the server
or network failed or because the format is not supported.
Turmeric can also be used to increase levels of brain-derived
neurotrophic factor (BDNF), which is a growth hormone in the
brain that, when low, is responsible for increased risk of
Alzheimer's disease, depression, and a host of other mental
ailments. The curcumin in turmeric has also been proven to
reverse symptoms of heart disease. Many other studies have found
a parallel function and effect of the substance on your heart as
compared to exercise.
Health benefits of turmeric
Philstar, February 2018
Antidepressants. Curcumin the
main substance in turmeric may be used as an effective and safe
therapy for treatment in patients with mild depression.
Arthritis management. Because curcumin is known for its powerful
anti-inflammatory and pain-reducing characteristics, it has an
amazing effects on people suffering from various types of
arthritis. Cancer treatment. A number of laboratory studies on
cancer cells have shown that curcumin does have anticancer
effects. It seems to be able to kill cancer cells and prevent
more from growing. It has the best effects on breast cancer,
bowel cancer, stomach cancer, and skin cancer cells. Diabetes
management. For lowering blood sugar and reversing insulin
resistance, there’s arguably no better natural treatment than
adding turmeric into your diet. Obesity. A study published in
the journal “Biofactors” showed that curcumin can help promote
weight loss. The researchers found that the anti- inflammatory
properties in curcumin were effective at suppressing the
inflammatory process of obesity, therefore helping to reduce
obesity and its “adverse health effects.” Cholesterol
regulators. One of the reasons heart disease is such a problem
in the U.S. is that people are developing pre-diabetes (high
blood sugar) at an alarming rate. A study done by “Drugs in R &
D found that curcumin was equal, or more effective than diabetes
medication at reducing oxidative stress and inflammation in the
treatment of high cholesterol. Painkillers. One of the more
widely accepted properties of curcumin in scientific communities
is its ability to manage pain. Therapeutic use of turmeric and
other curcumin-rich plants are displacing conventional medical
treatments and proving it’s a legitimate natural pain killer.
Regulation of Polyamine Metabolism by Curcumin for Cancer
Prevention and Therapy
Medical Sciences,
February 2018
Curcumin (diferuloylmethane), the natural
polyphenol responsible for the characteristic yellow pigment of
the spice turmeric (Curcuma longa), is traditionally known for
its antioxidant, anti-inflammatory, and anticarcinogenic
properties. Capable of affecting the initiation, promotion, and
progression of carcinogenesis through multiple mechanisms,
curcumin has potential utility for both chemoprevention and
chemotherapy. In human cancer cell lines, curcumin has been
shown to decrease ornithine decarboxylase (ODC) activity, a
rate-limiting enzyme in polyamine biosynthesis that is
frequently upregulated in cancer and other rapidly proliferating
tissues. Numerous studies have demonstrated that pretreatment
with curcumin can abrogate carcinogen-induced ODC activity and
tumor development in rodent tumorigenesis models targeting
various organs. This review summarizes the results of curcumin
exposure with regard to the modulation of polyamine metabolism
and discusses the potential utility of this natural compound in
conjunction with the exploitation of dysregulated polyamine
metabolism in chemopreventive and chemotherapeutic settings.
Supplements That Enhance Detoxification
Newsmax, February 2018
Curcumin, quercetin, hesperidin,
ellagic acid, naringenin and other flavonoids enhance phase II
detoxification. They also protect liver cells and other tissues
and organs. They are all powerful antioxidants and more
versatile than the antioxidant vitamins.
Antitumor activity of curcumin by modulation of
apoptosis and autophagy in human lung cancer
Oncology Reports, February 2018
Curcumin is known to
exhibit anticancer effects on various cancers with selective
cytotoxicity in tumor cells. Our results showed that curcumin
inhibited the viability of A549 cells time‑ and
dose‑dependently. In addition, a dosage-dependent A549 cell
apoptosis‑induction phenomena was observed by the curcumin
intervention. Moreover, obvious autophagy was induced after
curcumin‑treatment, characterized by the formation of
fluorescent particles [autophagic vesicles (AVs)] and
significant increase in ratio of LC3‑Ⅱ/LC3‑Ⅰ and Beclin1 as well
as decreased p62 expression. Furthermore, the effect of curcumin
on a substantial downregulation of phosphatidylinositol 3‑kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was
observed. It is worth noting that the inhibition of mTOR by
rapamycin or of PI3K/Akt by LY294002 augmented curcumin‑induced
apoptosis and autophagy, leading to significant inhibition of
cell proliferation. From these findings, it can be speculated
that curcumin potently inhibit the cell growth of NSCLC A549
cells through inducing both apoptosis and autophagy by
inhibition of the PI3K/Akt/mTOR pathway. These results support
the potential use of curcumin as a novel candidate in treatment
of human lung cancer.
Diabetes and Obesity Linked to Higher Cancer Risk: 4
Foods That Reduce This Risk
NDTV,
February 2018
Turmeric: The principle component of turmeric
is curcumin which is a potent antioxidant scavenging free
radicals and inhibiting the growth of cancerous cells. Almost
2000 published scientific papers have shown that curcumin has
the ability to kill cancer cells while not harming the healthy
cells.
Curcumin Protects against Atherosclerosis
Journal of Agricultural and Food Chemistry,
February 2018
Curcumin supplementation significantly
reduced TLR4 expression and macrophage infiltration in
atherosclerotic plaques. Curcumin also reduced aortic
interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α),
vascular cell adhesion molecule-1 (VCAM-1) and intercellular
adhesion molecule-1 (ICAM-1) expression, nuclear factor-κB
(NF-κB) activity, and plasma IL-1β, TNF-α, soluble VCAM-1 and
ICAM-1 levels. In addition, aortic sinus sections revealed that
curcumin treatment reduced the extent of atherosclerotic lesions
and inhibited atherosclerosis development. In vitro, curcumin
inhibited NF-κB activation in macrophages and reduced TLR4
expression induced by lipopolysaccharide. Our results indicate
that curcumin protects against atherosclerosis at least
partially by inhibiting TLR4 expression and its related
inflammatory reaction
Turmeric pills help woman survive blood cancer
Los Angeles Times, January 2018
In 2011, Ferguson decided to
take daily supplements of curcumin, the beneficial compound in
turmeric, every night. A couple of months after she began the
regimen, she started on a weekly course of hyperbaric oxygen
therapy. The non-traditional treatment involves breathing in
pure oxygen from an enclosed chamber with specific atmospheric
pressure adjustments. Since then, Ferguson's cancer has remained
stable and her blood counts are within a safe and normal range.
Of course, due to the close proximity of her introduction of
turmeric and the hyperbaric oxygen therapy, it's uncertain
whether it was the turmeric that cured the progression of her
disease. "The fact that our patient, who had advanced stage
disease and was effectively salvaged while exclusively on
curcumin, suggests a potential antimyeloma effect," the report
concludes. "We would recommend further evaluation of curcumin in
myeloma patients in the context of a clinical trial."
British Woman Beats Rare Cancer With 2 Teaspoons Of
This Per Day The
Alternative Daily, January 2018
Ferguson decided to try
treating herself with a “golden spice” called curcumin, which is
a naturally occurring chemical compound in the herb turmeric
after she had heard about how another woman (named Margaret) had
used it successfully to treat her myeloma. Ferguson began taking
eight grams (about two teaspoons) of curcumin per day for about
five years. As a result, she is now vastly improved to the point
where her cancer count is considered both manageable and
negligible. Jamie Cavenagh, professor of blood diseases at
London’s Barts Hospital, who has subsequently co-authored a
report on Ferguson’s case, believes curcumin was a decisive part
of her amazing recovery. As Cavenagh explains, “When you review
her chart, there’s no alternative explanation for her recovery
other than we’re seeing a response to curcumin.” Dr. Abbas
Zaidi, a hematologist at Barts NHS Health Trust, who contributed
to the report on Ferguson, also believes that curcumin played an
important role in her improvement.
Curcumin attenuates collagen-induced inflammatory
response through the “gut-brain axis”
Journal of Neuroinflammation, January 2018
Oral
administration of curcumin restored the imbalance between the
sympathetic and parasympathetic tones in CIA rats and increased
ChAT activity and expression of ChAT and VAChT in the gut,
brain, and synovium. Additionally, VGX eliminated the effects of
curcumin on arthritis and ACh biosynthesis and transport.
Electrophysiological data showed that curcumin markedly
increased neuronal excitability of the vagus nerve. Furthermore,
selective α7 nAChR antagonists abolished the effects of curcumin
on CIA. Our results demonstrate that curcumin attenuates CIA
through the “gut-brain axis” by modulating the function of the
cholinergic system. These findings provide a novel approach for
mechanistic studies of anti-arthritic compounds with low oral
absorption and bioavailability.
Healing foods
Navhindtimes.in January
2018
Curcumin is a powerful antioxidant with powerful
anti-inflammatory effects. Studies have shown that curcumin and
turmeric have antimutagenic and anticancer properties and have
also been shown to be effective against Alzheimer’s disease in
animal models. A glass of hot milk with a pinch of haldi is a
common household remedy for a cold and sore throat. Curcumin is
fat soluble and needs to be absorbed in the presence of fat.
Hence haldi should be fried along with the seasonings in oil.
Black pepper has also been found to increase the absorption of
cucurmin. Supplements containing haldi extracts or curcumin
should be taken after a meal as the fat in the meal helps in its
absorption.
The miracle of turmeric: How can this golden spice
help reinvigorate your health
Express,
January 2018
The 67-year-old, who had battled blood cancer
for five years, began taking daily doses of curcumin, one of the
main compounds of turmeric. More familiar as an ingredient in
curries the spice is also an ancient remedy for a variety of
ailments. While this natural approach won’t work for everyone
the Londoner’s cancer-cell count is now negligible. As Dieneke’s
doctors hail the remarkable results we take a look at turmeric
and the ways in which it may boost health. The spice,
recognisable by its golden colour, is ground from the dried root
of a plant called Curcuma longa. A relative of ginger it thrives
in warm, moist conditions and has long been used as a medicine
in Chinese and Indian cultures. Turmeric’s healing powers are
attributed to phytochemicals, compounds which are present in
many plants. Curcumin, which is found in turmeric, is claimed to
be one of the most powerful remedies in nature’s medicine
cabinet. Another benefit of turmeric may be combating
depression, stress and anxiety. It is claimed curcumin can be
used as a natural alternative to drugs such as Prozac, working
by inhibiting an enzyme in the brain that is responsible for
depression. There may be a double whammy as it is claimed
curcumin can also increase levels of serotonin and dopamine –
chemicals that boost happiness. The powers of curcumin could
even extend to improving the sex life of men by improving blood
flow to the genitals.
Wonder curry spice could be used to treat cancer
after stunning doctors
Leicester Mercury,
January 2018
Ms Ferguson began taking 8 grams of curcumin -
one of the main compounds in turmeric - each day in tablet form.
It’s the equivalent of about two teaspoons. Her illness has an
average survival of just over five years - making it one of the
most fatal forms of the disease. It was rapidly spreading -
causing increasing back pain - and she had already had a second
relapse. Dr Abbas Zaidi, a haematologist at Barts NHS Health
Trust, said: "Here we describe a myeloma patient who started a
daily dietary supplement of curcumin when approaching her third
relapse. "In the absence of further antimyeloma treatment the
patient plateaued and has remained stable for the last five
years with good quality of life." The remarkable improvement
described in BMJ Case Reports follows previous research into the
health benefits of turmeric which is packed with antioxidants.
Cancer patient, 67, ‘beats the disease with the help
of TURMERIC’ after five years of chemo failed
The Sun, January 2018
In 2011 she began taking daily doses of
curcumin, a key component of the spice turmeric, after another
two rounds of stem cell therapy failed. Dieneke took eight grams
of curcumin each night on an empty stomach. Dieneke took eight
grams of turmeric every night and her blood cancer stabilised.
Over the last five years her cancer has remained stable and her
blood counts are within the normal range, doctors report. She
has also maintained a good quality of life during this period,
according to the report. Curcumin is a micronutrient derived
from the herb turmeric, and has been used as a traditional
Indian medicine for centuries.
Foods That Can Help You Prevent from Getting Cancer
Your Health Mag, January 2018
Curcumin, a major component of
curry, contains curcumin, which blocks or reduces tumors.
Woman Halts Cancer in Its Tracks With Turmeric
Metro, January 2018
She took 8g of turmeric tablets every day
for years without further treatment, and has now shocked
doctors. ‘To the best of our knowledge, this is the first report
in which curcumin has demonstrated an objective response in
progressive disease in the absence of conventional treatment,’
her doctors, from Barts Health NHS Trust in London, wrote in the
British Medical Journal Case Reports. ‘In the absence of further
antimyeloma treatment the patient plateaued and has remained
stable for the past five years with good quality of life.’
Turmeric is widely used in Asian cuisine and helps create
distinctive colour in curries – but it would be impossible to
cure myeloma with regular cooking turmeric. It would be
impossible to treat cancer with regular kitchen turmeric, as it
contains just 2% curcumin.
What is curcumin? Brit woman claims the wonder spice
halted incurable blood cancer for a decade
International Business Times, January 2018
Dieneke Ferguson
said she takes 8gram curcumin every day in a tablet form to
fight the incurable myeloma. After all other treatments failed,
North London resident Ferguson decided to fight back and began
using curcumin — a component derived from a popular Indian spice
turmeric. She said she has been taking 8gram of the compound
every day in a tablet form and the result has been nothing less
than a miracle. "I have been on all sorts of toxic drugs and the
side-effects were terrifying. At one point I lost my memory for
three days, and in 2008 two of the vertebrae in my spine
collapsed so I couldn't walk," the cancer survivor said, as
quoted by the Daily Mail. "They injected some kind of concrete
into my spine to keep it stable." Her recovery has since baffled
doctors who are yet to come to a conclusion on the effectiveness
of curcumin. "Here we describe a myeloma patient who started a
daily dietary supplement of curcumin when approaching her third
relapse. In the absence of further antimyeloma treatment the
patient plateaued and has remained stable for the last five
years with good quality of life," Dr Abbas Zaidi, a
haematologist at Barts NHS Health Trust said in a report, which
mentions that her cancer cell count is currently
negligible."Curcumin is a polyphenol derived from the perennial
herb turmeric and has - for centuries - been used as a
traditional Indian medicine," explains Zaidi in the case study.
"The biological activity of curcumin is indeed remarkable." He
added that the pigment produces multiple effects through its
"natural antioxidant, anti-inflammatory, antiseptic and
analgesic properties"
Curcumin targets gut-brain axis in reducing
inflammation, study finds
Horsetalk,
January 2018
The research team from the China Pharmaceutical
University in Nanjing said many studies in recent years had
shown that taking curcumin by mouth eased collagen-induced
arthritis. A clinical trial, they noted, had shown that curcumin
was safe and effective for patients with rheumatoid arthritis.
However, studies had shown that its bioavailability was poor,
which raised questions about how it produced its
anti-inflammatory effect. They set out to explore whether the
gut-brain axis was involved in its therapeutic action. The
researchers found that curcumin did indeed reduce
collagen-induced arthritis through the gut-brain axis by
regulating the function of the cholinergic system
Chemopreventive and Antitumor Efficacy of Curcumin
in a Spontaneously Developing Hen Ovarian Cancer Model
Cancer Prevention Research, December 2017
Our results
demonstrated for the first time that daily curcumin intake leads
to a significant and dose-dependent reduction in spontaneous
ovarian cancer incidence and tumor growth, indicating a
tremendous role for curcumin as a chemopreventive strategy for
ovarian cancer.
The Effect Of Curcumin On Plasma Metabolomic Profile
In Atherogenic Diet Induced Rat Model Of Alzheimer’s Disease
Nutrition and Food Science, December 2017
Curcumin, a
polyphenol extricated from the plant Curcuma longa, has
demonstrated its remedial advantages in Alzheimer's ailment and
was utilized as a positive control. Curcumin exhibited a
potential therapeutic effect in high cholesterol diet induced
AD.
Curcumin reverses tobacco smoke‑induced
epithelial‑mesenchymal transition
Molecular
Medicine Reports, December 2017
Tobacco smoke is a major risk
factor for lung cancer. Epithelial‑mesenchymal transition (EMT)
is decisive in cancer invasion and metastasis, and therefore
promotes cancer progression. The chemopreventive effect of
curcumin on carcinogenesis has been reported in vivo and in
vitro. Curcumin treatment inhibited tobacco smoke‑induced
MAPK/AP‑1 activation, including ERK1/2, JNK and p38 MAPK
pathways, and AP‑1 proteins, and reversed EMT alterations in
lung tissue. The results of the present study provide new
insights into the molecular mechanisms of tobacco
smoke‑associated lung cancer and may open up new avenues in the
search for potential therapeutic targets in lung tumorigenesis.
Potent Remedies That Support the Liver
Care 2, December 2017
Turmeric is a potent spice with many
health benefits. Recent studies show it can improve circulation,
prevent cancer, reduce pain and detoxify the body. Thanks to
curcumin, a bioactive compound found in turmeric, this herb
helps the liver remove toxins and wastes from the body. It’s
also worth mentioning that curcumin increases production of
bile, and as a result improves liver function.
Exactly How Much Turmeric to Have a Day to Reap Its
Anti-Inflammatory Benefits
Pop Sugar, December 2017
"Turmeric is recommended for many
patients with inflammatory conditions such as Crohn's disease,
ulcerative colitis, autoimmune conditions like psoriasis,
rheumatoid arthritis, osteoarthritis, Parkinson's disease,
Alzheimer's disease, dementia, and cancers. Curcumin is the
compound found in turmeric," said Atlanta-based integrative
medicine physician Dr. Bindiya Gandhi. Arguably, the most
powerful aspect of curcumin is its ability to control
inflammation. "The journal Oncogene published the results of a
study that evaluated several anti-inflammatory compounds and
found that aspirin and ibuprofen are least effective, while
curcumin is among the most effective anti-inflammatory compounds
in the world," said Dr. Josh Axe, DNM, CNS, DC, bestselling
author of Eat Dirt. "This news should have reached every
household in the world after the study was conducted, because
inflammation puts people at risk for almost every disease
process known to man," he said. You can find turmeric in powder
culinary spice form and in its whole root form, as well as in
tincture, tablets, and capsules. "A good starting dose for its
anti-inflammatory benefits is 400 to 600 mg of standardised
powder or curcumin turmeric extract three times a day as
tolerated," Dr. Gandhi said.
Curcumin: common dietary supplement turned
anti-cancer compound?
Oxford University
Press, December 2017
Over the past few decades, curcumin, a
common food additive, has been identified as a potential
anti-inflmmatory and anti-cancer compound. Curcumin is a
phenolic compound extracted from the Curcuma longa plant, and
was traditionally used as a spice for improving flavor and color
into dishes of various Asian countries. Curcumin’s health
benefits are not a new or surprising finding — the brightly
colored compound has been used in Ayurvedic medicine for
centuries for its potent anti-inflammatory and anti-tumor
properties — but the fundamental mechanisms underlying its
anti-cancer potential still remain an active area of
interrogation. Intriguingly, curcumin has been shown to
sensitize multiple cancers to chemotherapy drugs, and several
recent studies have reported that curcumin is able to
specifically target cancer stem cells. . As suggested by other
groups, not only did we demonstrate that curcumin was able to
enhance the sensitivity of gemcitabine in these resistant cells,
we found that curcumin was also able to inhibit the growth of
cancer stem cells. In our study, we also discovered that
curcumin was regulating a class of non-coding RNA called “long
non-coding RNAs” (lncRNAs). LncRNA is a relatively newly
discovered type of non-coding RNA — RNA which does not make
protein — found to be dysregulated in most cancers. We
discovered that curcumin inhibits the expression of one of the
most well-known lncRNA-based oncogenes, a gene that drives
cancer, called PVT1. This lncRNA drives tumor progression
through the regulation of another well-recognized oncogene,
called EZH2. EZH2 is one of the oncogenes known to be involved
in drug resistance and is identified to be a potential drug-able
target. Though the generation of specific EZH2 inhibitors
remains challenging, the findings from our study indicate that
curcumin could be used to inhibit the expression of EZH2, as
well as the non-coding RNA that regulates EZH2. Considering that
curcumin is a commonly available health supplement, it presents
itself as a non-toxic compound and incredibly cost-effective
compound for the potential treatment of cancer patients.
Curcumin improves diabetes mellitus‑associated
cerebral infarction by increasing the expression of GLUT1 and
GLUT3
Molecular Medicine Reports, December
2017
Curcumin is characterized by anti‑inflammatory,
anti‑oxidative, antiviral, antifibrotic, anticoagulation and
glucose regulatory functions. Curcumin markedly decreased cell
apoptosis, indicating an anti‑apoptotic role of curcumin in the
brain. To further evaluate whether curcumin prevented cell
apoptosis by modulating the expression of GLUT1 and GLUT3, small
interfering RNAs targeting GLUT1 and GLUT3 were selected. It was
found that the knockdown of GLUT1 and GLUT3 inhibited the
abundance of GLUT1, GLUT3 and B‑cell lymphoma 2, even following
incubation with curcumin. These data showed that curcumin
protected brain cells from apoptosis and cerebral infarction,
predominantly by upregulating GLUT1 and GLUT3.
Natural Remedies for Tendonitis
Care 2, December 2017
An extract of the spice turmeric, which
is often used in curries to give them a yellowish color,
curcumin is an excellent choice in dealing with any type of
inflammation. While there are few studies on its use for
tendonitis, preliminary research published in the Journal of
Biological Chemistry showed that curcumin has a place in the
healing of tendonitis.
Curcumin Enhances the Efficacy of 5-FU in Colo205 Cell Lines
Proceedings, December 2017
Curcumin was observed to increase
the efficacy of 5-FU and accelerate the cytotoxic effect by
removing the cytostatic period seen in the first 6 h. The study
results show that the combination of 5-FU and curcumin in
Colo205 can reduce the dose by increasing the cytotoxic activity
of 5-FU and reducing the resistance to the anticancer drug.
Health benefits of the humble turmeric
Hindustan Times, December 2017
Turmeric is a root that is as
popular as ginger in Ayurveda. Many of its beneficial aspects
are due to its active compound, curcumin. Curcumin has a
profoundly anti-inflammatory effect on the body, and provides a
good defence system against diseases. Inflammation is the body’s
reaction to toxic elements in our environment, such as water
with heavy chlorine, air pollution, unhealthy oil (trans fats),
stress, lack of sleep, and overuse of chemical aromas,
deodorants, cleaning agents, etc.
Can
Curcumin be Employed to Promote the Integration of Oncology and
Natural Products?
Proceedings, December
2017
Curcumin inhibits NF-kB activation pathway at a step
before inhibitor kappa B alfa (IKBα) phosphorylation.
Preclinical in vivo and in vitro trials that combine curcumin
with tyrosine kinase inhibitors (TKIs) have shown that this
combination shows better results than each treatment alone.
Retrospectively evaluated seventeen NF-kB overexpressed cancer
patients were treated with i.v. and oral bioavailable
formulation of curcumin and appropriate TKIs. TKIs decision was
made according to genetic profiling (FoundationOne®). Toxicities
and response was evaluated according to RECIST and common
toxicities criteria. All patients are stage IV and heavily
pretreated. Our longest experience comes from adenoid cystic
carcinoma and he has treated for 72 months by oral curcumin and
8 months by i.v curcumin. Disease control rate was 89.3% (15/17)
and no any grade III-IV toxicities was observed related to
curcumin. Curcumin is multitargeted molecule with pleotrophic
nature. Curcumin inhibits NF-κB and related proteins which
promotes effectiveness of TKIs. And might be considered as long
as we have to use chemotherapy, radiotherapy and TKI.
Which spice wins for its medicinal properties?
Daily Sabah Health, December 2017
What makes turmeric, which
is quite rich in iron and manganese, a key ingredient in
alternative medicine is its active ingredient curcumin. Curcumin
is one of the best herbs for good health due to large amounts of
vitamins C and E. Turmeric is a lightened version of curcumin
that can be used in kitchens. Thanks to the curcumin in it,
turmeric regulates sleep patterns. It also prevents muscles from
getting tired very quickly and boosts sports performance. Some
studies indicate that by using turmeric, symptoms can be
decreased and inflammation-related conditions, including
arthritis, can be eased. Moreover, scientists have proven that
consuming turmeric helps to slow down the symptoms of
Alzheimer's disease. However, the signature benefit of turmeric
is in the treatment of inflammation.
Curcumin, quercetin and atorvastatin protected
against the hepatic fibrosis by activating AMP-activated protein
kinase
Journal of Functional Foods,
December 2017
Curcumin, quercetin, and atorvastatin protected
against the hepatic fibrosis by reducing hepatic fat
accumulation via AMPK up-regulation.
Curcumin Beats Diabetes Drug at Lowering Blood
Sugar: Study
News Max, December 2017 “Natural
remedies, however, can be very effective,” he adds. “A large
number of studies have shown that curcumin can be very helpful
at decreasing blood sugar as well as the complications of
diabetes.” Other studies have shown its effectiveness in
treating other aspects of diabetes, both in Type 1 and Type 2
according to the Website, Diabetes Self Management. David Spero,
R.N., says that research conducted by Beijing University of
Chinese Medicine and McGill University showed that curcumin
reduced both blood sugar and cholesterol levels. Curcumin
suppressed the activities of white blood cells called
macrophages that cause inflammation as well as slowed down many
of the complications of diabetes, in which inflammation plays a
role. Curcumin improved insulin function by helping the hormone
get into the cells thus reducing insulin resistance. In a study
of 240 people in Thailand, curcumin prevented prediabetes from
developing into full blown diabetes. Roughly 16 percent of the
people studied in the placebo group progressed to Type 2
diabetes within 9 months while nobody in the group receiving 250
milligrams of curcuminoids from supplements progressed. Curcumin
protects beta cells, which produce insulin. Studies have found
that beta cells grew faster and lived longer in rats who
consumed curcumin. In addition to its diabetes-fighting
properties turmeric has been found to be an effective
anti-inflammatory — even more effective than aspirin or
ibuprofen and even Celebrex without the potentially deadly side
effects of these drugs. As a cancer treatment, multiple studies
have shown that curcumin holds promise in fighting against skin
cancer, breast cancer, bowel and stomach cancers. A 2007 study
found that curcumin combined with chemotherapy killed more
cancer cells than chemotherapy alone. The American Cancer
Society states that curcumin interferes with the development,
growth, and spread of cancer cells. Curcumin has also been shown
in multiple studies to be more effective than the popular drug
Zoloft to beat depression,” adds Teitelbaum. “And if that’s not
enough, current research suggests it may also decrease the risk
of developing Alzheimer’s disease. The only side effect reported
to my knowledge is that you start feeling fantastic.”
Studies that prove Curcumin can kill at least 3
types of cancer
emaxhealth,
November 2017
Lung cancer: The effects of curcumin in chronic
obstructive pulmonary disease (COPD) airway inflammation and
lung cancer progression, were tested in an animal model study.
Scientists administered to mice, the natural anti-inflammatory
agent curcumin, 1% in diet before and during weekly non-typeable
Hemophilus influenzae (NTHi ) exposure, which has been
associated with the pathology of COPD. It was observed that
curcumin significantly reduced the number of visible lung tumors
in the absence of NTHi exposure by 85% and in the presence of
NTHi exposures by 53%. It is important to note that Nuclear
factor-kappaB (NF-kappaB) is frequently expressed in lung cancer
and preneoplastic lesions, and the effect of curcumin in
decreasing the migratory and invasive ability of A549 ( lung
carcinoma cells) cells by inhibiting adiponectin expression is
probably mediated through NF-κB/MMP pathways. Ovarian carcinoma:
In vitro and in vivo experiments of curcumin with and without
docetaxel (chemotherapy medication) were done using human
ovarian cancer cell lines. It was observed that Curcumin
inhibited inducible NF-kappaB activation and suppressed
proliferation in vitro. In vivo dose-finding experiments
revealed that 500 mg/kg orally was the optimal dose needed to
suppress NF-kappaB and signal transducers and activators of
transcription 3 activation and decrease angiogenic cytokine
expression. Colorectal cancer::Cyclo-oxygenase 2 (COX2), which
mediates prostaglandin synthesis during inflammation, and which
is selectively overexpressed in colon tumours, is thought to
play an important role in colon carcinogenesis. But, a study
that tested Human colon epithelial cells (HCEC) and SW480 colon
carcinoma against curcumin, concluded that curcumin inhibits
COX2 induction by the colon tumour promoters, tumour necrosis
factor alpha or fecapentaene-12, which are fecal mutagens that
are naturally produced in the human colon and have a role in
neoplastic transformation of the colon. It is important to note
that curcumin, not only affects signaling of proteins like tumor
necrosis factor-(TNF) or the nuclear factor NF-κB. Curcumin also
blocks interleukin-1 (IL-1) signalling, which as previously
mentioned has been associated with the pathology of different
types cancer. Therefore, the powerful ability to interfere in
the mechanisms involved in cancer, make curcumin a natural
cancer killer.
Drastically Reduce Your Colon Cancer Risk
Care2.com,
November 2017
Curcumin, one of the phytonutrients found in
the spice turmeric, has been found in numerous studies to reduce
colon cancer risk. A study found in Cancer Prevention Research
showed that curcumin suppresses the ability of colon cancer
cells to proliferate, suggesting it is helpful both in the
prevention and treatment of the condition.
Curcumin Exerts Effects on the Pathophysiology of
Alzheimer's Disease
Frontiers in Neurology,
November 2017
Curcumin, a major polyphenol from curry spice (Curcuma
longa), has been reported to inhibit Aβ aggregation, Aβ-induced
inflammation, and the activities of β-secretase and
acetylcholinesterase in in vitro studies (12, 13). Moreover, in
in vivo studies, oral administration of curcumin has resulted in
the inhibition of Aβ oligomerization, Aβ deposition, and tau
phosphorylation in the brains of AD animal models, as well as
led to the improvements in behavioral impairment in animal
models (12). In our previous study, we found that chronic
curcumin administration ameliorates Aβ1-42 induced AD-related
cognitive deficits (13). However, more information underlying
the mechanism should be explored. Based on these research
results, we speculated that curcumin may ameliorate AD
pathogenesis by regulating PI(3,5)P2 and TRPML1 expression
levels. To validate it, we first detect the effects of curcumin
on lysosomes and the cell viability of hippocampal HT-22 cells
that treated with Aβ1-42. Sequencing technique was then used and
TRPML1 was identified as the most upregulated gene that affected
by curcumin. Afterward, the effects of curcumin on the
autophagy-related proteins were also analyzed in vitro. Besides,
we also determined that curcumin ameliorated autophagy–lysosome
dysfunction by regulating PI(3,5)P2 and TRPML1 in vivo. Our
study suggests that curcumin might be one of the most promising
compounds for the interference of AD therapies.
Turmeric is the spice of the year
Lifestyle.ynaija.com, November 2017
Turmeric's major
component is curcumin, a powerful, medicinal substance that has
anti-inflammatory properties, helps fight cancer and diabetes,
aids digestion, combats heart diseases, works as an
anti-oxidant, works magic on the skin, reduces bloating, calms
severe menstrual pain and essentially, solves more than a
handful of life’s problems. Turmeric tea has potential to ease
health conditions such as Alzheimers, athritis, obesity and
chest pain. Its anti-inflammatory properties help boost the
immune system and protect the brain. Its principal component,
curcumin also contains anticancer properties and has been found
useful in the treatment of brain, bone and breast cancer.
The anti-inflammatory activity of curcumin
Journal of Biological Chemistry, November 2017
The spice
turmeric, with its active polyphenol curcumin, has been used as
anti-inflammatory remedy in traditional Asian medicine for
centuries. Many cellular targets of curcumin have been
identified, but how such a wide range of targets can be affected
by a single compound is unclear. We conclude that the paradigm
of metabolic bioactivation uncovered here should be considered
for the evaluation and design of clinical trials of curcumin and
other polyphenols of medicinal interest.
Turmeric may reduce inflammation from osteoarthritis
Daily Herald, November 2017
Over the past two decades there
have been many medical studies evaluating the effect of turmeric
extracts including curcumin and reducing the pain and
inflammation associated with osteoarthritis. The overall results
of these studies strongly indicate that curcumin and other
extracts of turmeric reduce inflammation as well as pain levels
in patients with osteoarthritis. A recent study published in the
Journal of Medicinal Food demonstrated that extracts of turmeric
have a significant impact on the inflammation and pain
associated with osteoarthritis. The study was a meta-analysis,
which means that it combined the data from many smaller studies
and the final result indicated that an ancient spice is very
effective at reducing the inflammation and associated symptoms
of osteoarthritis. This meta-analysis included middle-aged and
elderly people who have symptoms of osteoarthritis in five or
more joints. All of the studies demonstrated a significant
reduction in pain and stiffness. They also concluded that
approximately 1000 mg of curcumin a day gave a reduction in
symptoms equivalent to over-the-counter analgesics. This is
important because turmeric extracts and curcumin do not have the
same gastrointestinal and heart-related side effects (bleeding,
high blood pressure and increased risk of heart attack)
associated with commonly used pain medications. The side effects
seem to be increased in the elderly -- the very people most
affected by osteoarthritis.
Effects of Curcumin on Lipid Peroxidation and Antioxidant
Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing
Ehrlich Solid Tumor
Proceedings, November
2017
Cancer is the second most common cause of death in the
world. Several natural products have been studied for anticancer
activity and for prevention or repair of oxidative injury.
Curcumin is one of the natural products of high medicinal
interest. This study showed that curcumin suppresses tumor
progression, and alleviates the lipid peroxidation and improves
antioxidant status in the tissues of solid tumor-bearing mice.
Turmeric's Anti-Inflammatory Properties
Science Trends, November 2017
It has been suggested that the
compound curcumin helps the immune system destroy amyloid
plaque, reducing the production of inflammatory cytokines. In
doing so, brain function deterioration is reduced, slowing down
the development of Alzheimer's disease. Epidemiological studies
have looked at the neuroprotective effect of curcumin and have
demonstrated that regular consumption has reduced other
cognitive deficits in the elderly. Over the years curcumin has
been a main focus for research regarding its strong anti-tumor
effects. In fact, several preclinical trials have demonstrated
curcumin to have both chemopreventive and anti-tumor effects
against certain types of cancer. This naturally occurring
polyphenolic compound recently has shown promise as a dietary
therapy for pancreatic cancer. Of course, it shouldn't be
thought of as a primary means for treating cancer, but it may
reduce tumor promotion and minimize the spread of cancer.
Turmeric has anti-inflammatory abilities containing more than
two dozen compounds which may help relieve osteoarthritis pain.
Again, it’s the compound curcumin that works as an
anti-inflammatory agent. Clinical studies have found that
curcumin provided protection to joint inflammation in
individuals with osteoarthritis. Ulcerative colitis is a
chronic, inflammatory bowel disease causing inflammation in the
digestive tract. The disease tends to flare up and subside at
random. Studies have shown people with ulcerative colitis who
took curcumin had a significantly lower relapse rate than people
who did not take curcumin. A meta-analysis showed curcumin had a
high effect in reducing symptoms of depression, such as
irritable mood, reduced interest in pleasurable activities,
fatigue or feelings of worthlessness. The analysis suggests that
curcumin could possibly have a role in treating the symptoms of
major depression.
Curcumin suppresses Notch‑1 signaling: Improvements
in fatty liver and insulin resistance in rats
Molecular Medicine Report, November 2017
Curcumin is a
well‑known phenolic substance and has many pharmacological
effects associated with metabolism. Curcumin administration led
to a downregulation in the expression of lipogenic genes,
including sterol regulatory element‑binding protein, fatty acid
synthase and acetyl‑CoA carboxylase (P<0.05). The expression of
inflammation‑associated genes, including nuclear factor‑κB,
tumor necrosis factor‑α and prostaglandin‑endoperoxide synthase
2 were also suppressed. The results of the present study suggest
that the hepatic Notch‑1 pathway can be suppressed via curcumin
treatment, which may ameliorate fatty liver and insulin
resistance in rats subjected to a high fat diet.
Foods for brain memory and function
The Medium, November 2017
According to Uma Naidoo, turmeric
is an ingredient found in curry that appears to be responsible
for de-plaguing the brain. Naidoo also explains that turmeric,
also referred to as "Indian gold," has properties that benefit
the brain, making you almost as bright as its own fiery
complexion. The ingredient responsible for this powerful herb's
effects on the brain is known as curcumin. Naidoo says,
“Curcumin has been found to possess neuroprotective properties,
and may help shield the brain against Alzheimer’s disease (AD)
by binding to and eliminating toxic beta-amyloid plaques, which
are a hallmark of AD."
Anti-neuroinflammatory effect of curcumin
International Journal of Molecular Medicine, November 2017
Curcumin is the main curcuminoid present in Curcuma longa and it
has been previously reported to exhibit a wide range of
pharmacological activities. Curcumin suppressed the secretion of
inflammatory mediators through an increase in the expression of
HO-1. Curcumin induced HO-1 transcription and translation
through the Nrf2/antioxidant response element signaling pathway.
Inhibitory experiments revealed that HO-1 was required for the
anti-inflammatory effects of curcumin. Further mechanistic
studies demonstrated that curcumin inhibited neuroinflammation
by suppressing NF-κB and MAPK signaling pathways in
Pam3CSK4-activated microglial cells. The results of the present
study suggest that curcumin may be a novel treatment for
neuroinflammation-mediated neurodegenerative disorders.
Terrific Turmeric
Steinbach
Online, November 2017
Due to recent research, curcumin has
been nicknamed the "master off-switch for inflammation." It has
been shown to help relieve pain and inflammation by modulating
the inflammatory pathways that affect heart, joints, liver,
gastrointestinal tract, brain, cellular health and the immune
system! This makes curcumin useful for relieving the pain in
osteoarthritis, rheumatoid arthritis and bursitis as well as in
digestive conditions such as ulcerative colitis, Crohn's
disease, celiac disease, gastritis and gastric ulcers. Curcumin
has the ability to block more than 30 different inflammation
pathways! Curcumin also protects against inflammatory calcium
loss from our bones and has been shown to slow prostate cell
proliferation in addition to supporting healthy cholesterol and
blood pressure levels. Curcumin has liver-protective effects and
is a powerful liver detoxifier. It helps to prevent the build-up
of toxins, enhance glutathione levels, supports bile production
and solubility as well as improve digestive function. Curcumin
may help reverse certain forms of liver cirrhosis to some
degree, and is thought to be especially helpful for people who
regularly drink alcohol or use common painkillers, both of which
damage cause liver damage. Studies suggest that curcumin can
also reduce the severity of liver injury induced by iron
overdose, cholestasis and carbon tetrachloride intoxication. In
addition to supporting the liver processes, managing
inflammation is also vital in aiding detoxification.
Inflammation control is needed because the detoxification
process involves the release of toxic metabolites from our cells
and tissues in order to expel them from the body. On the way to
being eliminated, these toxins can trigger inflammatory
reactions and cause tissue damage.
Curcumin, was originally
researched for Alzheimer's disease because studies found there
is a much lower incidence and prevalence of Alzheimer's in India
than in North America. The association between curry consumption
and cognitive level in certain populations were researched and
it was found that those who ate curry foods performed better on
a standard test than those who never or rarely ate curry!
Alzheimer's disease degrades the nerve cells in the brain
through inflammation in glial cells, the formation of
beta-amyloid plaques, metal toxicity, and oxidative damage.
Curcumin acts as a powerful anti-inflammatory and antioxidant in
the brain. It can also break down plaques and has the potential
to guard against their development, plus it supports healthy
neurotransmitter function, improving memory and helping to
prevent cognitive decline.
Curcumin alleviates liver oxidative stress in type 1
diabetic rats
Molecular Medicine Reports,
November 2017
The aim of the present study was to determine
the effects of curcumin on antioxidants using a rat model of
type 1 diabetes. The results provide evidence that oxidative
stress in the STZ‑induced diabetic rat model may be attenuated
by curcumin via the activation of the Keap1‑Nrf2‑ARE signaling
pathway, as evidenced by a decrease in the blood glucose
concentration and an increase in the transcription of several
antioxidant genes.
Natural ingredients to help manage aches and pains
Body and Soul,
November 2017
Turmeric is best known as a powdered spice used
to give foods flavour and colour – think curries. It contains a
natural chemical compound called curcumin that scientists have
found to have anti-inflammatory and antioxidant properties.
Research suggests turmeric and its components can potentially
alleviate arthritis inflammation and pain. With curcumin
accounting for only 3-5% of turmeric, you’re unlikely to get
enough from diet alone, so consider a supplement to help boost
levels.
Protective Effect of Curcumin Against Oxidative
Stress-Induced Injury in Rats with Parkinson's Disease
Cellular Physiology and Biochemistry, November 2017
Background/Aims: The study aimed to investigate the protective
effect of curcumin against oxidative stress-induced injury of
Parkinson’s disease (PD) through the Wnt/β-catenin signaling
pathway in rats. This study suggests that curcumin could protect
against oxidative stress-induced injury in PD rats via the
Wnt/β-catenin signaling pathway.
Keep breast cancer at bay
Telangana Today,
November 2017
The spice that gives curry its beautiful yellow
colour contains a chemical called curcumin. The studies have
shown that curcumin supplements could play a role in helping
fight breast cancer tumours.
Effect of Curcumin on the Diversity of Gut Microbiota in
Ovariectomized Rats
Nutrients, November
2017
Curcumin has been proven to have a weight-loss effect in
a menopausal rat model induced by ovariectomy. In conclusion,
estrogen deficiency induced by ovariectomy caused changes in the
distribution and structure of intestinal microflora in rats, and
curcumin could partially reverse changes in the diversity of gut
microbiota.
Reduce Inflammation with an Ancient Wonder Herb
Huffington Post, November 2017
Curmeric is a spice and a part
of the ginger family that has been used for thousands of years.
It's rich in a powerful natural phenol called curcumin. This
wonder herb has been shown to be effective in treating low
moods, either alone or in combination with an antidepressant.
Curcumin contains powerful phytochemicals that reverse
inflammation, and chronic inflammation has been shown to
contribute to the development of a wide variety of disorders,
depression being one that may be closely linked. A 2014
randomized control study compared three groups of 20
participants each. The three groups were given curcumin alone,
Prozac® + 1g of oil based curcumin, or Prozac alone for a
six-week period. They then had their low moods measured on a
common scale. Surprisingly, the group on curcumin alone did just
as well as those on Prozac alone. While there was not a major
statistical significance among any of the three groups, the
group on the combination scored best. The researchers found no
safety concerns with the daily curcumin usage and concluded
"This study provides first clinical evidence that curcumin may
be used as an effective and safe modality for treatment in
patients with MDD [major depressive disorder] without concurrent
suicidal ideation or other psychotic disorders.”
Curcumin modulates covalent histone modification and
TIMP1 gene activation to protect against vascular injury in a
hypertension rat model
Experimental and
Therapeutic Medicine, November 2017
Hypertension is a leading
risk factor for morbidity and mortality. Previous studies have
reported that curcumin has anti‑oxidation and anti‑aging effects
and inhibits histone deacetylase activity. In conclusion,
curcumin could relieve extracellular matrix degradation and
interstitial fibrosis induced by hypertension, and lower blood
pressure. It could also serve a function in improving vascular
structure through inhibiting the expression of HDAC1, thereby
promoting TIMP1 transcription activation and suppressing the
expression of MMP‑2 and TGFβ.
Turmeric Is a Top Culinary Medicine
Natural Products Insider,
November 2017
Nutritionists, functional medicine GP's and
physiotherapists commonly use curcumin for it's
anti-inflammatory qualities. And it's no wonder considering six
major scientific trials all found curcumin to possess a potent
anti-inflammatory action, which is completely non-toxic in
nature. A study evaluating several pharmaceutical
anti-inflammatory drugs, found that aspirin and ibuprofen are
the least potent, while curcumin is among the most potent
anti-inflammatory and anti-proliferative agents available..
Arthritis is a debilitating inflammatory disorder. Thankfully
curcumin has been found to help. A recent study out of Japan
evaluated its relationship with the inflammatory cytokine known
to be involved in in the rheumatoid arthritis process.
Scientists discovered that curcumin "significantly reduced"
these inflammatory markers. In fact its anti-inflammatory
qualities are so strong a 2007 study compared curcumin and
cortisone and found they were equal in potency! Most
pharmaceutical anti-inflammatory drugs are contraindicated to
use over the long-term, but turmeric is not only safe but
beneficial for your overall well-being. Curcumin has been shown
to equal in effectiveness to the drug metformin in the
management of diabetes, but without negative side effects. (5)
In the study curcumin was shown to lower blood glucose levels
and reverse insulin resistance by suppressing glucose production
in the liver. Another study found curcumin improved metabolic
function and reduced the risk of plaque buildup in the arteries
of type-2 diabetes patients. (6) Curcumin also acts as an
anti-diabetic and antioxidant in patients with type-1 diabetes.
With anti depressants prescriptions on an all time high, there
has been a flood or recent trials attempting to get to the cause
of depression. The core issue has finally been identified as
inflammation. And curcumin has been found to be comparable to
prescription antidepressant drugs.. In 2014 a randomized control
trial took 60 volunteers diagnosed with major depressive
disorder (MDD) and compared the effect of curcumin to fluoxetine
(Prozac). (9) Researchers discovered that the principal
curcuminoid in turmeric is not only as effective as Prozac in
managing depression, but it doesn't carry with it all the
dangerous side effects as anti-depressive drugs do. According to
the paper, "This study provides first clinical evidence that
curcumin may be used as an effective and safe modality for
treatment in patients with MDD.”
Efficacy and safety of turmeric and curcumin in
lowering blood lipid levels in patients with cardiovascular risk
factors
Nutrition Journal, November 2017
Turmeric and curcumin may protect patients at risk of CVD
through improving serum lipid levels. Curcumin may be used as a
well-tolerated dietary adjunct to conventional drugs.
Curcumin Shrinks Aggressive Mesothelioma Tumors in
New Study
Surviving Mesothelioma,
November 2017
The latest study of cucumin in malignant
mesothelioma treatment was conducted by French scientists at
several different research centers. The team used cells taken
from rats that had been induced to develop one of the deadliest
and most aggressive subtypes of asbestos cancer called
sarcomatoid mesothelioma. The rats began to develop sarcomatoid
mesothelioma tumors in their abdomens within weeks of being
injected with asbestos. The French scientists tested curcumin on
cells from these tumors to determine the ideal killing dose. The
team then used the sarcomatoid mesothelioma rats to test the
treatment in vivo, in living animals. Compared with an
epigenetic drug called SAHA, curcumin injected directly into the
peritoneal cavities of sick rats was more effective and started
to destroy their tumors in less two weeks. "The treatment of
tumor-bearing rats with 1.5 mg/kg curcumin on days 7, 9, 11 and
14 after tumor challenge dramatically reduced the mean total
tumor mass at day 16," reports Dr. Daniel L. Pouliquen, lead
author on the report in Oncotarget. Earlier this year,
scientists in the Department of Experimental Medicine at the
University of Rome conducted a similar experiment and that found
that intraperitoneal curcumin extended survival in mice with
mesothelioma. In 2015, mesothelioma researchers with Flinders
University in Australia determined that curcumin had the ability
to keep mesothelioma tumors from giving rise to their own new
blood vessels. That study suggested that curcumin could become a
supplemental treatment for certain mesothelioma patients.
Curcumin is able to
inhibit breast cancer cells Oncology Letters, October 2017 The present study investigated
the inhibitory effect of curcumin on human breast cancer MCF‑7
cells and investigated the potential underlying molecular
mechanisms. MCF‑7 cells were cultured with curcumin at different
concentrations and time points. The proliferation of MCF‑7
cells in the group treated with curcumin was markedly decreased
compared with the control, with the greatest inhibitory effect
at a concentration of 20 µM. The expression of Bax mRNA was
increased and Bcl‑2 mRNA expression was decreased compared with
the control. Additionally, protein expression of NF‑κB and IκB
was increased. The data indicate that curcumin is able to
inhibit breast cancer cell proliferation, possibly by regulating
the NF‑κB signaling pathway.
The Remarkable
Anti-Cancer Activities of Curcumin
Experiment.com October 2017 Curcumin, a diferuloylmethane, is a phytochemical derived
from the rhizome of Curcuma longa, a member of the ginger
family. It has been used orally and safely as a spice and
for medicinal purposes for many thousands of years in southern
Asia and India. There are numerous published articles on
laboratory, animal, and human studies examining its effect
as an anti-proliferative and anti-inflammatory on a wide variety
of diseases. It enhances induction of
tumor antigen-specific, PD-1-positive,,
Cytotoxic T Lymphocytes [the Death Receptor] (1,2);,,
It arrests cancer, cells in various phases of the cell cycle,
and induces apoptosis primarily through a,
mitochondrial pathway involving,, caspase-8-dependent BID
cleavage (3);,, It has been shown,
to inhibit constitutive NF-kB activation, induce G1/S arrest,,,
suppress proliferation, and induce apoptosis in mantle cell
lymphoma (4);,, It induces apoptosis in human
melanoma cells through a Fas Receptor/Caspase-8 pathway,
independent of p53 (5);,, It suppresses the
proliferation of human vascular endothelial cells,,
in vitro and inhibits the Fibroblast Growth Factor-2-induced
angiogenic,, response in-vivo (6);,,
It induces apoptosis in the human acute myelogenous leukemia
cell, line HL-60, believed to, occur
through the mitochondrial pathway involving caspase-8, BID
cleavage,, cytochrome C release, and
caspase-3 activation (7);,, It downregulates
action of NF-kB and the antiapoptotic genes,,
regulated by NF-kB,, a critical role in
inhibiting cancer cell survival and proliferation in pancreatic
cancer (8);,, It suppresses expression of
NF-kB, Bcl-2 and Bcl-XL in multiple,, myeloma
cell lines (9);,, It potentiates the antitumor
activity of gemcitabine in an in-vivo,, pancreatic cancer model
through, suppression of proliferation,
angiogenesis, and inhibition of NF-kB -regulated,
gene products (10);,, It induces gemcitabine
sensitivity in pancreatic cancer cells through modulation of
miR-200 and miR-21, expression (11);,,
It inhibits tumor growth and angiogenesis in an orthotopic mouse
model of,, human pancreatic cancer (12);,,,
A liposomal-encased, formulation of
curcumin was studied in pancreatic cancer cell lines in vitro
and in vivo, by, intravenous infusion, in athymic mice at the
M.D. Anderson Cancer Center in, Houston,
Texas. Liposomal Curcumin was shown to down-regulate the NF-kB,
machinery, suppress tumor growth, and induce apoptosis in vitro,
and demonstrated a reduction in, tumor burden and angiogenesis
in vivo (13);,, It inhibits growth and
survival of human head and neck squamous carcinoma cells with
modulation of of, NF-kB signalling (14).
A Powerful And Cheap
Supplement That You Aren't Using Enough
MensXP.com October 2017 The effects of curcumin are very similar to any synthetic
anti-inflammatory drug. While synthetic drugs have side effects
and may only be prescribed when needed, curcumin on the other
hand, is a natural substance without side effects. Inflammation
is an essential physiological function. Without our body's
inflammation mechanism we would have no protection against
pathogens. Although, short term (acute) inflammation works in
our favor, but prolonged (chronic) inflammation which is a
result of modern day stressful lifestyle is a key contributor to
many western diseases. This includes heart disease, cancer,
metabolic syndrome, Alzheimer's and much other health
detrimental conditions. Including curcumin in the diet ensures
the prevention of chronic inflammation. This is one benefit that
our grandmother knew well before science confirmed it. This is
the reason why you got a glass of hot milk mixed with turmeric
every time you got injured. Curcumin is proven to relieve pain
significantly at higher doses of 400-500mg. The pain relief
benefits were found in post-operative patients and people
suffering from arthritis and osteoporosis. This is comparable to
2g acetaminophen in potency. (a powerful painkiller).
Turmeric is a potential
aid against precancerous cells
The Plaid Zebra, October 2017
Curcumin is one of the most powerful non-pharmaceutical
anti-inflammatory compounds out there. It may provide the
greatest benefits for stomach, breast, skin, bowel, brain,
ovarian, colon, and prostate cancers. In fact, The American
Cancer Society says that turmeric can be a potential treatment.
It works by protecting the body from free radicals. Studies have
also shown that curcumin also interrupts the progression,
spread, and growth of cancerous cells. It also helps with the
inflammation that is associated with the progression of cancer.
The American Cancer Society mentions a study in which curcumin
kills cancer cells in isolation, as noted in laboratory
dishes.,,Curcumin inhibits COX-2, the enzyme that leads to
negative inflammation that eventually leads to cancer. It also
takes away the oxygen that fuels cancer cells. Additionally, it
kills large cell B-cell lymphoma cells, and prevents the rebirth
of cancer stem cells. Turmeric and curcumin have
anti-carcinogenic agents. Carcinogens are greatly impactful to
the development of cancerous cells. It mediates
anti-carcinogenic action by raising levels of antioxidant
enzymes. Curcumin and its derivatives are associated with
anti-tumour activity.
Curcumin and Pancreatic
Cancer Treatments
HealthProfessionalRadio.com
October 2017 Ajay Goel, PhD., is Director of Translational
Genomics and Oncology, and the Director of the Center for
Gastrointestinal Research at the Baylor Scott & White Research
Institute, Baylor University Medical Center in Dallas, TX. He is
currently researching the prevention of gastrointestinal cancers
using integrative and alternative approaches, including
botanical products. Two of the primary botanicals he is
investigating are curcumin (from turmeric) and boswellia.
Dr. Goel is a member of the American Association for Cancer
Research and the American Gastroenterology Association and is on
the international editorial boards of World Journal of
Gastroenterology and World Journal of Gastrointestinal Oncology.
Segment overview: Dr. Ajay Goel, PhD, senior author on a recent
study published in the Oxford University Press’ journal
“Carcinogenesis” that shows clinical relevance for combining
curcumin with chemotherapy to overcome chemoresistance in
pancreatic cancer patients.
Neuroprotective effects
of curcumin
Molecular Medicine Reports,
October 2017 Curcumin is a natural product with
antimutagenic, antitumor, antioxidant and neuroprotective
properties. The results of the present study suggest that
pretreatment with curcumin can prevent the development of LIDD
in rats. It was revealed that treatment with curcumin
significantly reduced interleukin (IL)‑1β and IL‑6, iNOS, COX‑2
and MMP‑9 levels in rats with LIDD. In addition, treatment with
curcumin reduced the mRNA expression levels of TGF‑β1 and
TGF‑β2, whereas it increased the mRNA expression levels of BDNF
in rats with LIDD. In conclusion, the present findings indicate
that curcumin may exert protective effects on LIDD development,
exerting its action through the regulation of iNOS, COX‑2,
TGF‑β1/2, MMP‑9 and BDNF.
A compound in turmeric
could make cancer cells more sensitive to radiation
Scroll, September 2017 Pre-treatment with curcumin
– a safe herbal compound derived from turmeric – makes cancer
stem cells sensitive to radiation therapy. It has found that
combined effect of curcumin and exposure to radiation was
markedly more effective in lowering AP-1 levels thereby
rendering cells unviable for growth and replication. When
treated with radiation alone, there was delayed but increased
rate of proliferation and tumor formation. The mechanism of
curcumin-induced inhibition lends credibility to AP-1 as a drug
target and therapeutic utility of curcumin for
radio-sensitisation of cervical cancer stem cells for better
treatment outcomes.
Natural ways to support
a healthy liver
News-Medical.net September 2017 Turmeric is a bright orange spice which has been long used in
Indian cuisine and Ayurvedic medicine. Turmeric is reported to
have the ability to protect the liver from damage. Animal
studies have shown that mice fed curcumin, one of the active
ingredients in Turmeric, suffered less liver damage over time
compared with those on a normal diet. Curcumin has even been
found to have a beneficial effect in the treatment of liver
disorders.
Investigating the effect
an over-the-counter anti-inflammatory supplement called Curcumin
has on the onset of Alzheimer’s.
AustralianAgeingAgenda.com
September 2017 The preliminary findings suggested a longer
period of time taking the supplement was required and the study
has been extended for two years, Dr Goozee said. “We believe
having people on the long-term Curcumin may have some benefit in
being able to slow their accumulation or reduce what’s already
there.”
Curcumin inhibits
endoplasmic reticulum stress
Experimental and Therapeutic
Medicine, September 2017 The aim of the present study was to
observe the dynamic changes of the growth arrest and DNA
damage‑inducible 153 (GADD153) gene and caspase‑12 in the brain
tissue of rats with cerebral ischemia‑reperfusion injury (CIRI)
and the impact of curcumin pretreatment. A total of 60 rats were
randomly divided into the normal group (N), the sham operation
group (S), the dimethyl sulfoxide control group (D) and the
curcumin treatment group (C). For group D and C, 12 (T1), 24
(T2) and 72 h (T3) of reperfusion were performed after 2 h
ischemia. The expression levels of GADD153 and caspase‑12 in the
brain tissue were detected and compared among the groups by
immunohistochemistry, immunofluorescence double staining and
western blotting. The expression levels of GADD153 and
caspase‑12 were increased at T1compared with groups N and S, and
the expression of caspase‑12 peaked at T2 in group D, while
GADD153 was increased until T3 in group D. Compared with group
D, the expression levels of GADD153 and caspase‑12 in group C at
T2 and T3 were significantly decreased (P<0.05). Endoplasmic
reticulum stress is involved in the pathological process of
CIRI. Curcumin may decrease the expression levels of the above
two factors, thus exhibiting protective effects against CIRI in
rats.
Can curry spice really
help banish your aches and pains? Yes - and women may benefit
from nature's painkiller the most
DailyMail, September 2017 Curcumin is a strong anti-inflammatory agent and chronic
inflammation is the precursor of the vast majority of
cancers.,,Turmeric helps cells regulate their growth and
survival, including the recycling of worn out cells, and the
self-destruction of abnormal cells which have the potential to
form tumours. Turmeric is traditionally used to support weight
loss. Curcumin boosts the metabolic rate of ‘good’ brown fat
cells so they burn more fat as a fuel – this is one reason why
you may find yourself sweating after eating a spicy curry.,,The
latest news is that curcumin also helps to regulate the
production of hormones linked with obesity, such as resistin
(which links obesity with insulin resistance and type 2
diabetes), leptin (the satiety hormone) and adiponectin (a
hormone involved in fat breakdown). Curcumin has beneficial
effects against skin inflammation by quenching free radicals,
reducing inflammation.,,In psoriasis, this helps to slow the
over-production of cells that lead to plaque formation.
Curcumin Alleviates the
Functional Gastrointestinal Disorders of Mice In Vivo
Journal of
Medicinal Food, September 2017 Curcumin is a natural
polyphenol extracted from the turmeric rhizome, which has a wide
range of biological activities, but until now the effects of
curcumin on the gastrointestinal peristalsis have not been fully
understood. In vivo study, we observed the effects of curcumin
on gastric emptying and intestinal propulsion rates of mice in
normal state and in delayed state by atropine (ATR) or nitric
oxide precursor L-arginine (L-Arg). An in vitro study explored
the direct effects of curcumin on the intestinal contractility,
but were studied through measuring spontaneous contraction of
isolated jejunum of mice. Our results showed that intragastric
administration of curcumin (200 mg/kg/day) for 10-20 days
significantly improved gastric emptying and intestinal
propulsion rates of mice delayed by ATR. Moreover, intragastric
administration of curcumin (200 mg/kg/day) for 15 days also
significantly improved mice gastric emptying and intestinal
propulsion rates delayed by L-Arg.
Potential Role of Curcumin Against Biofilm-Producing
Organisms on the Skin: A Review
Phytotherapy Research, September 2017
Turmeric root (Curcuma
longa) is predominantly used as a spice, but has also long been
known to possess antimicrobial, analgesic, antiinflammatory, and
anticancer properties. One predominant group of active compounds
in turmeric are curcuminoids, namely bright yellow-pigmented
curcumin. While modern science has yet to fully investigate the
therapeutic claims of turmeric and its derivatives, results have
proven promising in decreasing pain and inflammation in
arthritis, improving insulin sensitivity in diabetes, and even
curing a variety of infections. Curcumin has demonstrated
bactericidal efficacy against a variety of infections when
administered with antibiotics in several clinical studies, with
consistent antimicrobial activity demonstrated in vitro, as well
as in urinary tract infections, gingival infections, and chronic
wound infections. Hypothesized mechanisms of action include
curcumin's ability to perturb bacterial membranes, disturb
protofillament assembly, and even impair bacterial virulence
factors.
Shield against
Alzheimer's dementia
Times of India, September 2017
"Turmeric contains a curcumin, the bright yellow chemical
that gives turmeric its colour, which acts like a protective
shield towards the problem," he added. There is a great body of
evidence to prove the positive impact of turmeric on prevention
and treatment of AD. As per Antioxidants-2016 - an academic
publication of Multidisciplinary Digital Publishing Institute
(open-access publisher), termed turmeric as an alternative
therapy for AD. Similarly, London based Alzheimer's society
noted that curcumin in turmeric can break down Amyloid-beta
plaques (amino acids that play a key role in development of
dementia).
Health Benefits of
Turmeric: 5 Proven Benefits of Turmeric India.com September 2017 Curcumin present in turmeric
improves the brain function by boosting Brain-Derives
Neurotrophic Factor (BDNF), a growth hormone present in the
brain. It drives the process of formation of new neuron
connections. Neurons develop new connections in a specific area
of the brain. Turmeric also helps lower the risk of brain
diseases by boosting BDNF in the brain. The increased levels of
BDNF delays or reverses several age-related brain damages and
brain diseases. Turmeric contains curcumin, which is beneficial
for your heart. Curcumin improves your heart health by improving
the function of the blood vessel lining called endothelium.
According to some studies, curcumin improves the endothelium
function. Studies showed that it is as effective as the drug
Atorvastatin or works as well as exercises. Curcumin also
reduces oxidation and inflammation, which in turn improve the
heart health.
Long-term stabilisation of myeloma with curcumin
British Medical Journal, August 2017
Here, we describe a
myeloma patient who started a daily dietary supplement of
curcumin when approaching her third relapse. In the absence of
further antimyeloma treatment, the patient plateaued and has
remained stable for the last 5 years with good quality of life.
Curcumin is a polyphenol derived from the perennial herb Curcuma
longa (turmeric) and has, for centuries, been used as a
traditional Indian medicine. Several reports published over the
two decades have claimed various health benefits of curcumin and
this has led to its increasing popularity as a dietary
supplement to prevent or treat a number of different diseases.
The biological activity of curcumin is indeed remarkable. It is
a highly pleiotropic molecule which possesses natural
antioxidant, anti-inflammatory, antiseptic and analgesic
properties. More recently, it has demonstrated antiproliferative
effects in a wide variety of tumour cells including myeloma
cells and exerts its antiproliferative effects through multiple
cellular targets that regulate cell growth and survival.
New science confirms curcumin every day reverses
cancer
Natural News, August 2017
A
report in the British Medical Journal illustrates how a woman
has beaten blood cancer with the help of turmeric. In 2007,
67-year-old Dieneke Ferguson was diagnosed with myeloma and she
progressed to stage three within 15 months. Three failed rounds
of chemotherapy and four failed stem cell transplants later,
doctors told her she had very little hope. Four years after her
initial diagnosis, she took matters into her own hands and
started taking a daily dose of curcumin, the key component of
turmeric. She took eight grams every evening on an empty
stomach.
Since then, her cancer has stabilized and her blood
counts have returned to normal. The BMJ report says that
Ferguson’s results suggest that turmeric could be used to help
myeloma patients in the future, adding: “The fact that our
patient, who had advanced stage disease and was effectively
salvaged while exclusively on curcumin, suggests a potential
antimyeloma effect of curcumin.” No other possible explanation
for her recovery. The report’s co-author, Jamie Cavenagh, said
that there is no other possible explanation for her remarkable
recovery beyond the curcumin. She continues to take the tablets
to this day. The scientists are recommending further evaluation
in clinical trials to pursue the possibility of using it as an
official treatment. This could prove difficult, however, because
doctors cannot prescribe it until it has been tested in
wide-scale trials that cost millions. Natural compounds cannot
be patented, so finding an investor would be extremely
difficult.
Turmeric helped cancer patient, 57, beat myeloma
after five years of treatment
The Sun,
August 2017
Dieneke Ferguson took eight grams of curcumin
each night for five years and her cancer has remained stable.
Curcumin is a polyphenol derived from the perennial herb
turmeric and has been used as a traditional Indian medicine for
centuries. Curcumin is a natural antioxidant,
anti-inflammatory, antiseptic and has analgesic properties,
according to the BMJ report. More recently, it has demonstrated
an ability to slow or inhibit cell growth in a wide variety of
tumour cells, including myeloma. It has also been found to help
alleviate a range of other health problems.
Turmeric may help fight the most common type of
cancer found in infants
Mic.com August 2017
A popular spice frequently used in curries may be combatting the
most common cancer cells afflicting infants, according to a
recent study. Turmeric, a vibrant yellow spice seen in dishes
such as roasted vegetables and soups, contains a chemical called
curcumin. Recent research suggests that curcumin helps destroy
neuroblastoma tumor cells, which often start in the embryo or
fetus. These particular tumor cells can become resistant to drug
treatments, scientists say, meaning that a new treatment plan
involving turmeric could make all the difference. For children,
neuroblastoma can be a severe health obstacle. About 700 new
cases appear each year in the U.S., mostly diagnosed in kids
younger than age 5. This type of cancer can delay development
and cause hearing loss or other disabilities. That aside, the
medical treatment itself can be difficult: Kids can suffer
serious side effects or damage from traditional methods such as
chemotherapy, for example. “This research demonstrates a novel
method of treating this tumor without the toxicity of aggressive
therapy that can also have late effects on the patient’s
health,” Tamarah J. Westmoreland, a lead researcher on the
study, said in a release.
Chemical from turmeric helps treat cancer in
children: Study
TheHindu.com August 2017
Scientists in the U.S. have found yet another use for curcumin,
the bioactive component of turmeric that is widely used in
Indian cuisine, this time to treat cancer in children.
Researchers at Nemours Children’s Hospital and the University of
Central Florida (UCF) have found that nanoparticles loaded with
curcumin can target and destroy neuroblastoma tumour cells.
Children aged five or less are most commonly affected. In their
study, the researchers attached curcumin to cerium oxide
nanoparticles and tested the nano-curcumin formulation in cell
lines of a high-risk form of neuroblastoma. “This formulation
induced substantial cell death in neuroblastoma cells while
producing no or only minor toxicity in healthy cells,” says the
report published in Nanoscale . Curcumin has been shown to have
substantial anti-cancer ability, but its low solubility and poor
stability have restricted its use in therapeutic applications.
The study demonstrates a treatment method “without the toxicity
of agressive therapy” and shows that nanoparticles can be “an
effective delivery vehicle” for cancer drugs, said a statement
from UCF.
Starving Prostate Cancer With What You Eat for
Dinner
University of Texas, August 2017
Curcumin combined with other nutrients has anti-cancer
properties. The researchers first tested 142 natural compounds
on mouse and human cell lines to see which inhibited prostate
cancer cell growth when administered alone or in combination
with another nutrient. The most promising active ingredients
were then tested on model animals: ursolic acid, a waxy natural
chemical found in apple peels and rosemary; curcumin, the bright
yellow plant compound in turmeric; and resveratrol, a natural
compound common to red grapes or berries. “These nutrients have
potential anti-cancer properties and are readily available,”
says Tiziani. “We only need to increase concentration beyond
levels found in a healthy diet for an effect on prostate cancer
cells.” The new research paper also demonstrates how the
plant-based chemicals work together. Combining ursolic acid with
either curcumin or resveratrol prevents cancer cells from
gobbling something that they need to grow, glutamine. This is a
neat solution: blocking the uptake of a nutrient needed by
prostate cancer cells with nutrients that are commonly in the
human diet.
Curcumin attenuates the development of thoracic
aortic aneurysm by inhibiting VEGF expression and inflammation
Molecular Medicine Reports, August 2017
curcumin exerts a
marked effect on aortic aneurysm development. In rat tissues,
treatment with curcumin resulted in reduced aneurysm size and
restored the wavy structure of the elastic lamellae. In
addition, curcumin decreased neovascularization and the
expression of VEGF. Immunohistochemical analysis indicated that
curcumin significantly inhibited infiltration of cluster of
differentiation (CD)3+ and CD68+ cells in TAA. Furthermore,
curcumin treatment decreased the expression of vascular cell
adhesion molecule‑1, intracellular adhesion molecule‑1, monocyte
chemoattractant protein‑1 and tumor necrosis factor‑α.
Collectively, the results demonstrated that angiogenesis and
VEGF expression were increased in the aortic wall in TAA.
Treatment with curcumin inhibited TAA development in rats, which
was associated with suppression of VEGF expression. In addition,
curcumin attenuated inflammatory cell infiltration and
suppressed inflammatory factor expression in the periaortic
tissue of TAA.
Underlying Mechanisms ID'd in Curcumin
Resensitization of CA Cells
HealthDay News,
August 2017
Curcumin can resensitize chemoresistant
pancreatic ductal adenocarcinoma (PDAC) cells through inhibition
of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis,
according to a study published online July 17 in Carcinogenesis.
The researchers reported the resensitization of chemoresistant
PDAC cells by curcumin through inhibition of the PRC2-PVT1-c-Myc
axis. Curcumin sensitized chemoresistant cancer cells inhibited
expression of the PRC2 subunit enhancer of zeste homolog-2 and
its related long non-coding RNA PVT1 using gemcitabine-resistant
PDAC cell lines. Curcumin also prevented spheroid formation and
down-regulated several genes driving self-renewal. In vitro
findings were confirmed in a xenograft mouse model, with
inhibition of gemcitabine-resistant tumor growth by curcumin.
"Overall, this study establishes clinical relevance for
combining curcumin with chemotherapy to overcome chemoresistance
in PDAC," the authors write.
Curcumin sensitizes pancreatic cancer cells to
gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA
PVT1 expression
Carcinogenesis, August
2017
Accumulating evidence indicates that curcumin, a
phenolic compound extracted from turmeric, can overcome de novo
chemoresistance and re-sensitize tumors to various
chemotherapeutic agents. Using gemcitabine-resistant PDAC cell
lines, we found that curcumin sensitized chemoresistant cancer
cells by inhibiting the expression of the PRC2 subunit EZH2 and
its related lncRNA PVT1. Curcumin was also found to prevent the
formation of spheroids, a hallmark of CSCs, and to down-regulate
several self-renewal driving genes. In addition, we confirmed
our in vitro findings in a xenograft mouse model where curcumin
inhibited gemcitabine-resistant tumor growth. Overall, this
study indicates clinical relevance for combining curcumin with
chemotherapy to overcome chemoresistance in PDAC.
Kitchen spice helps woman beat cancer
israelnationalnews.com August 2017
Dieneke Ferguson, 67,
battled myeloma for five years, thought she had lost, and then
tried a key component of a common kitchen spice: curcumin. Now,
five years later, her cancer cell count is negligible, the Daily
Mail reported. Her recovery was so remarkable it was featured
in the British Medical Journal. However, the report emphasized
that few - if any - of myeloma sufferers used curcumin on its
own, without conventional treatments. And co-author Jamie
Cavenagh, who works at London’s Barts Hospital as a specialist
in blood disease, said many of his patients take curcumin at
some point, but it doesn't work for everyone. "A lot of my
patients take curcumin at different stages of their treatment. I
don’t object to it," Cavenagh said. " Dieneke’s is the best
response I have observed and it is clear-cut because we had
stopped all other treatment. I have not seen such a convincing
response before." "When you review her chart, there’s no
alternative explanation [for her recovery] other than we’re
seeing a response to curcumin." Myeloma is a type of blood
cancer, and to treat it, Ferguson first tried three rounds of
chemotherapy and four stem cell transplants. Ferguson currently
takes 8 grams of curcumin a day (equivalent to two teaspoons of
powered curcumin), mostly to ensure the disease does not come
back.
Cancer breakthrough: Trendy spice could be key to
killing tumours
Express, August 2017
The
curcumin chemical in turmeric has shown promise destroying
neuroblastoma tumour cells.
Could a turmeric extract help to treat pancreatic
cancer?
Medical News Today, August 2017
A common obstacle in the treatment of pancreatic cancer is drug
resistance. However, new research has shown that curcumin - a
compound that can be found in turmeric - can help to overcome
the resistance to chemotherapy. Curcumin is the active compound
found in plants such as turmeric, and more and more studies have
been pointing to the therapeutic potential of the compound for
various conditions, ranging from cancer to diabetes. Preclinical
studies have suggested that the compound has various
antioxidant, neuroprotective, anti-inflammatory, and
anticarcinogenic properties. "By treating certain cells with
small doses of curcumin, we were able to reverse the pathways
that lead to chemoresistance," says Dr. Goel. "This is an
important breakthrough that could lead to better prognosis and
longer lives for patients with chemoresistant pancreatic
cancer." Previous studies have shown that curcumin has
preventative benefits, but to the authors' knowledge, this is
the first study that shows the beneficial effect of the plant
extract in combination with chemotherapy and its advantages in
overcoming drug resistance.
Baylor Scott & White Research Institute Shows
Curcumin Protects Against Chemoresistant Pancreatic Cancer
Healthcare Magazine, August 2017
Baylor Scott & White
Research Institute scientists found curcumin, a plant-based
medicinal compound, can help overcome chemotherapy resistance in
pancreatic ductal adenocarcinoma, the country’s fourth leading
cause of cancer-related deaths. According to researchers,
resistance to chemotherapeutic drugs is a major challenge for
PDAC patients. Initially, patients may respond to chemotherapy
but, as cancer stem cells form, patients’ bodies may become
immune to chemotherapy drugs. The Baylor Scott & White study
stated curcumin can act as an adjunct to chemotherapy to battle
this. “By treating certain cells with small doses of curcumin,
we were able to reverse the pathways that lead to
chemoresistance,” Dr. Ajay Goel, director of gastrointestinal
research and translational genomics and oncology at Baylor Scott
& White Research Institute, said in a statement. “This is an
important breakthrough that could lead to better prognosis and
longer lives for patients with chemoresistant pancreatic
cancer.” Goel said his team had identified two key players in
regulating drug resistance. Researchers found that when
pancreatic cancer cells were treated with curcumin, the natural
compound inhibited pathways associated with chemotherapy drug
resistance—increasing reception to first-line drug therapy.
Researchers also found curcumin can prevent the formation of
spheroids, in turn reducing tumor growth and recurrence.
Currently, Goel and his research team are continuing to explore
the benefits of curcumin. There are clinical trials underway
studying the role of curcumin in cervical, breast, and
colorectal cancers.
Curcumin Compound in Turmeric May be Used to Help
Fight Cancer in Children: Scientists
NDTV.com, August 2017
A team of scientists from the United
States of America have found that a bioactive compound in
turmeric known as curcumin can also cure cancer in children.
Neuroblastoma is one of the most common cancers in children
below the age of five years. The cancer starts in early nerve
cells and commonly forms in the tissue of the adrenal glands,
near the kidneys. It is also associated with developmental
delays, hearing loss and other disabilities.
Turmeric can be used to fight cancer in children,
find US scientists
Economic Times, August
2017
Researchers at Nemours Children's Hospital and the
University of Central Florida (UCF) have recently found that the
nanoparticles loaded with curcumin can offer a novel treatment
to target and destroy neuroblastoma tumor cells.
Wound healing activity of curcumin conjugated to hyaluronic
acid: in vitro and in vivo evaluation.
PubMed, August 2017
Studies on proliferation, antioxidant
activity and scratch wound healing carried out in human
keratinocyte cells revealed that HA-conjugated curcumin
treatment enhanced cell proliferation, decreased oxidative
damage induced by H2O2 and also improved migration of cells in
scratch wounds as compared to treatment with native curcumin. HA
conjugated curcumin exhibited bactericidal activity in dark and
phototoxicity when irradiated with blue light against antibiotic
resistant bacteria. Furthermore, wound healing efficacy studied
in diabetic mice demonstrated that topical application of the
conjugate on wounds led to better healing as compared to
treatment with HA-free curcumin and HA alone. These results
suggest that HA conjugation is a promising formulation of
curcumin for enhancing its healing efficacy.
Researchers Show Curcumin Protects Against
Chemoresistant Pancreatic Cancer
NewsWise.com August 2017
Curcumin is known for its powerful
anti-inflammatory and antioxidant benefits, but a new study by
researchers at Baylor Scott & White Research Institute reveals
an additional benefit: its potential to overcome chemoresistance
in pancreatic ductal adenocarcinoma (PDAC), a common but
aggressive form of cancer in the pancreas. The study, “Curcumin
sensitizes pancreatic cancer cells to gemcitabine by attenuating
PRC2 subunit EZH2, and the lncRNA PVT1 expression,” recently was
published in Carcinogenesis, an integrative cancer research
journal. Previous research demonstrated the advantages of taking
curcumin preventatively, but this is the first study of its kind
to demonstrate benefits of curcumin as an adjunct to
chemotherapy. Resistance to chemotherapeutic drugs is a major
challenge in caring for patients with PDAC, the fourth leading
cause of cancer-related U.S. deaths. Patients may respond to
chemotherapy initially, but as cancer stem cells form, the body
can develop drug resistance. Now, researchers have developed an
improved understanding of the molecular events underlying the
development of pancreatic stem cells and the role that
curcumin—the main component of turmeric—plays in overcoming
resistance to vital chemotherapy drugs.
Curry spice helped woman, 67, to beat blood cancer
Metro, August 2017
Dieneke Ferguson, 67, thought she had
exhausted all options available after undergoing three rounds of
chemotherapy and four stem cell transplants as she battled
myeloma. However, she then turned to a product called curcumin,
which is an ingredient of the spice turmeric, and her recovery
was so incredible it has been featured in the British Medical
Journal. Although curcumin features in kitchen turmeric, it only
makes up around 2%, so Dieneke takes the ingredient in tablet
form so she can get 8g a day. After five years of taking the
tablet, that she heard about on a cancer support group, her
cancer cell count is negligible.
The Benefits Turmeric Has on Your Skin
The Weekly Challenger, August 2017
Scientific studies as
recent as 2017 preach the anti-inflammatory and wound-healing
properties of turmeric, due to the curcumin inside the plant.
Other studies have found that turmeric can help reduce skin
damage, including damage due to sun exposure, pollution,
smoking, aging, and acne.
How curry spice helped a dying woman beat cancer:
Sufferer, 67, turned to kitchen cupboard staple turmeric after
five years of failed treatment
Mail Online,
August 2017
How curry spice helped a dying woman beat cancer:
Sufferer, 67, turned to kitchen cupboard staple turmeric after
five years of failed treatment. Dieneke Ferguson was diagnosed
with the blood cancer myeloma in 2007 and underwent three rounds
of chemotherapy as well as four stem cell transplants. She tried
Curcumin, a component of turmeric, and five years on, her cancer
cell count is negligible, with her recovery featuring in the
British Medical Journal. Curcumin has been linked to a host of
benefits, including for heart disease.
5 Foods That Help Fight Cancer
The Quint, August 2017
Curcumin (turmeric extract) works
brilliantly with cancer patients and balances the side effects
of chemo by boosting immunity. Its highly anti-microbial and
anti-inflammatory and that helps because cancer is an
inflammatory disease.
Synergistic Interplay between Curcumin and Polyphenol-Rich Foods
in the Mediterranean Diet: Therapeutic Prospects for
Neurofibromatosis 1 Patients
Nutrients,
August 2017
After six months, patients adopting a traditional
MedDiet enriched with 1200 mg curcumin per day presented a
significant reduction in the number and volume of cutaneous
neurofibromas; these results were confirmed in subsequent
evaluations. Notably, in one patient, a large cranial plexiform
neurofibroma exhibited a reduction in volume (28%) confirmed by
Magnetic Resonance Imaging. We hypothesize that the combination
of a polyphenol-rich Mediterranean diet and curcumin was
responsible for the beneficial effect observed on NF1. This is,
to the best of our knowledge, the first experience with curcumin
supplementation in NF1 patients. Our report suggests that an
integrated nutritional approach may effectively aid in the
management of NF1.
The best immune system-boosting foods
Coach, August 2017
A component of turmeric called curcumin,
which gives the spice its orange-yellow colour, has been shown
to have a potent stimulatory effect on the immune system. A
study carried out by American and Chinese researchers last year
found the consumption of curcumin resulted in the body producing
more white blood cells, which then removed a tuberculosis
causing bacteria from infected cells.
Family Living Focus: Turmeric
Lancaster Farming, August 2017
Curcumin, the active substance
in turmeric, is a powerful antioxidant. Antioxidants aid against
cell damage. Curcumin lowers the level of two enzymes in the
body that cause inflammation. Curcumin stops platelets from
clumping together to form blood clots. Curcumin has been found
to reduce the symptoms of bloating and gas in people suffering
with indigestion.
Curcumin converts Foxp3+ regulatory T cells to T helper 1
cells in patients with lung cancer
Journal
of Cellular Biochemistry, August 2017
The effect of curcumin
on inhibiting cancer has been recognized, but the mechanism
remains elusive. This study tests a hypothesis that
administration of curcumin down regulates Tregs in lung cancer
(LC) patients. In this study, a group of LC patients was treated
with curcumin. The peripheral Tregs and T helper (Th) 1 cells
were analyzed by flow cytometry. The mechanism by which curcumin
regulated the Tregs was observed by cell culture approaches. The
results showed that the frequency of peripheral Treg was
markedly higher in LC patients than that in healthy subjects,
which was suppressed after treating with curcumin for 2 weeks.
The peripheral Th1 cells were increased in LC patients after the
curcumin therapy. The data of the in vitro experiments showed
that curcumin converted the LC patient-isolated Tregs to Th1
cells via repressing the gene transcription of forkhead
protein-3 and increasing the expression of interferon-γ. In
conclusion, curcumin can convert LC patient-isolated Tregs to
Th1 cells. The results suggest that curcumin may improve the
antitumor immunity by regulating the tumor specific immune
tolerance.
Compounds in Apples, Grapes and Other Plant Foods
Stop Prostate Cancer in Mice, Study Shows
Prostate Cancer News, July 2017
Researchers tested 142
natural compounds in food for prostate-cancer-fighting
properties. They discovered that combinations of ursolic acid,
resveratrol and curcumin stopped the disease. Ursolic acid is
found in apple peels and the herb rosemary, resveratrol in red
grapes and berries, and curcumin in the spice turmeric. The
study, “Combinatorial treatment with natural compounds in
prostate cancer inhibits prostate tumor growth and leads to key
modulations of cancer cell metabolism,” was published in the
journal npj Precision Oncology. To start with, the University
of Texas researchers tested the compounds on prostate cancer
cells in a lab. They evaluated the substances alone and in
combinations. When the team discovered that ursolic acid,
resveratrol and curcumin might inhibit prostate cancer growth,
they tested all possible combinations of the compounds in mice
with prostate cancer. Some combinations prevented tumor growth
in the animals, with no toxic effects. Scientists already know
that chemicals in apple peels, turmeric and green tea reduce
inflammation, a risk factor for cancer because it damages normal
cells. The researchers also wanted to know how the compounds
inhibited tumor growth. They studied metabolic pathways, or
chemical transformations needed to nourish cancer cells. They
found that ursolic acid, combined with either resveratrol or
curcumin, kept cancer cells from consuming glutamine, a compound
the cells need to grow. Denying the cells glutamine starved
them.
Natural Compounds in Ordinary Foods Beat Prostate
Cancer
News Max, July 2017
They first
tested 142 natural compounds on mouse and human cell lines to
see which inhibited prostate cancer cell growth when
administered alone or in combination with another nutrient. The
most promising active ingredients were then tested on model
animals: ursolic acid, a waxy natural chemical found in apple
peels and rosemary; curcumin, the bright yellow plant compound
in turmeric; and resveratrol, found in red grapes and
berries.,,The found that when combined with either curcumin or
resveratrol, ursolic acid prevented the uptake of glutamine, a
nutrient necessary for cancer growth.,,"These nutrients have
potential anti-cancer properties and are readily available,"
says Stafano Tiziani. Combinations of the nutrients, he says,
"have a better effect on prostate cancer than existing
drugs.,,"The beauty of this study is that we were able to
inhibit tumor growth in mice without toxicity," Tiziani
said.,,The study was published in Precision Oncology.
Pre-treatment with curcumin - a safe herbal compound
derived from turmeric – makes cancer stem cells sensitive to
radiation therapy.
Down To Earth, July 2017
The study builds upon earlier findings that pre-treatment with
curcumin - a safe herbal compound derived from turmeric – makes
cancer stem cells sensitive to radiation therapy. It has found
that combined effect of curcumin and exposure to radiation was
markedly more effective in lowering AP-1 levels thereby
rendering cells unviable for growth and replication. When
treated with radiation alone, there was delayed but increased
rate of proliferation and tumor formation. The mechanism of
curcumin-induced inhibition lends credibility to AP-1 as a drug
target and therapeutic utility of curcumin for
radio-sensitization of cervical cancer stem cells for better
treatment outcomes.
Natural Ways to Lower Your Cholesterol
FitCommerce.com July 2017
Turmeric, the spicy yellow
ingredient found in Indian food, contains the active ingredient,
curcumin. Recent research suggests that curcumin may reduce
cholesterol by interfering with intestinal cholesterol uptake,
increasing the conversion of cholesterol into bile acids, and
increasing the excretion of bile acids. Curcumin has powerful
antioxidant and anti-inflammatory properties and may help
prevent the oxidation of LDL cholesterol to a more dangerous
form that is more likely to end up in your arteries.
Curcumin protects against acute renal injury by
suppressing JAK2/STAT3 pathway in severe acute pancreatitis in
rats
Experimental and Therapeutic Medicine,
July 2017
The results showed that curcumin significantly
decreased serum amylase, Cr and BUN levels, and alleviated
pancreatic and renal histological changes in SAP rats.
Furthermore, curcumin markedly decreased serum TNF‑α and IL‑6
levels and downregulated renal protein levels of JAK2/STAT3
pathway components. These results proved that curcumin
ameliorates acute renal injury in a rat model of SAP. The
molecular mechanism of its effect may be associated with the
suppression of the JAK2/STAT3 pathway to reduce TNF‑α and IL‑6
levels in SAP‑induced acute renal injury. Therefore, the
findings of the present study revealed the potential use of
curcumin for the prevention and treatment of SAP and the
associated renal injury.
Prostate Cancer Cells Can Be Treated With Natural
Compounds Present In Apple, Red Grape & Turmeric
The Science Times, July 2017
The researchers performed the
tests of the compounds individually and also in combination.
They identified three key compounds that played effectively in
halting the growth of the prostate cancer cells. The three
effective compounds are curcumin, ursolic and resveratrol. A
bright yellow curcumin is a natural compound present in
turmeric, and ursolic acid can be found in the apple peel.
Another important natural compound resveratrol is present in
berries and red grapes. The researchers combined the ursolic
acid with either resveratrol or curcumin and tested it in the
mice with induced prostate cancer. They noticed that the
compounds stopped the necessary uptake of the important amino
acid glutamine by the prostate cancer cells. The uptake of this
amino acid helped the prostate cancer cells to grow. Now the
prevention of the glutamine's uptake forced the cells to starve.
This starvation ultimately led to the death of the prostate
cancer cells and simultaneously halted the growth of the tumor
in the mice. One important fact is natural compounds curcumin,
resveratrol, and ursolic acid caused no toxic effects on mice.
The researchers found that the concentrations of the natural
compounds in the mice were higher than they are normally present
and consumed through the diet. However, the findings of the
study have indicated promising outcome to prevent and treat the
prostate cancer cells.
Life-Changing Benefits Of Turmeric
Elite Daily, July 2017
Studies show that, in India,
diagnoses of Alzheimer's disease are pretty low, and it appears
to be due to turmeric's major role in the Indian diet. Curcumin
helps to improve working memory, as well as attention span and
mood in elderly adults. According to a 2014 study, 60 healthy
adults showed significantly improved performance on attention
and working memory tasks only one hour after receiving a single
dose of 400 mg of curcumin, compared with those who received a
placebo. Curcumin can
kill damaged cells while still leaving other cells healthy
and intact, unlike chemotherapy. According to GreenMedInfo,
turmeric reduces post-bypass heart risk by 56 percent. Not only
that, but the effects it has on heart health are similar to the
effects that aerobic exercise has on heart health, and it
improves vascular function in post-menopausal women. Curcumin
can possibly be just as effective as an antidepressant.Its work
with depression is related to its anti-inflammatory
properties because people with depression have greater
inflammation and oxidative stress, which can affect all
major organs in the body, including the brain, according to
Psychiatry Advisor.
Apples and Curry May Starve Prostate Cancer Cells
Vital Updates, July 2017
The study authors discovered
cancer-limiting effects with curcumin, which is found in the
“wonder spice” turmeric, as well. “These nutrients have
potential anti-cancer properties and are readily available,”
said corresponding author Stefano Tiziani, assistant professor
in the Department of Nutritional Sciences and Dell Pediatric
Research Institute at University of Texas at Austin. One of the
most important findings that the researchers uncovered was how
chemical combinations could limit glutamine metabolism in cancer
cells, which need the substance to survive. Specifically, the
researchers found that combining ursolic acid with resveratrol
or curcumen made the biggest impact.
Targeting multiple pro-apoptotic signaling pathways
with curcumin in prostate cancer cells
PLoS
One, July 2017
The mechanisms by which curcumin promoted cell
death in these cells were associated with cell cycle arrest,
increased reactive oxygen species, autophagy and the Unfolded
Protein Response. Furthermore, the upregulation of ER stress was
measured using key indicators of ER stress: Glucose-Regulated
Protein 78, Inositol-Requiring Enzyme 1 alpha, Protein Disulfide
isomerase and Calreticulin. Chronic ER stress induction was
concomitant with the upregulation of pro-apoptotic markers
(caspases 3,9,12) and Poly (ADP-ribose) polymerase. The
downregulated proteins include anti-apoptotic and anti-tumor
markers, supporting their curcumin-induced pro-apoptotic role in
prostate cancer cells. Taken together, these data suggest that
curcumin may serve as a promising anticancer agent by inducing a
chronic ER stress mediated cell death and activation of cell
cycle arrest, UPR, autophagy and oxidative stress responses.
Relieve Pain Naturally
The
Alternative Daily, July 2017
Curcumin is now one of the most
effective anti-inflammatory agents known to man, and you’ll see
curcumin supplements on most health store shelves across the
globe. Ancient civilizations came to refer turmeric, and hence
it’s active ingredient curcumin, as an almost holy plant, in
large part because of it’s amazing healing powers. Curcumin
works by regulating cytokines, proteins and enzymes that are
linked to inflammation. This has lead many scientists to
conclude that curcumin may be one of the most effective ways to
treat chronic neurodegenerative, cardiovascular, metabolic and
neoplastic diseases.
Curcuminoids modify lipid profile in type 2 diabetes
mellitus: A randomized controlled trial
Science Direct, July 2017
Curcuminoids supplementation can
reduce serum levels of atherogenic lipid indices including
non-HDL-C and Lp(a). Therefore, curcuminoids supplementation
could contribute to a reduced risk of cardiovascular events in
dyslipidemic patients with T2D.
Curcumin reduces hippocampal neuron apoptosis and
JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's
disease: protecting spatial learning and memory
Journal of Neurorestoratology, July 2017
Curcumin relieved
spatial learning and memory deficits, hippocampus neuronal
apoptosis, and reduced JNK-3 and p-JNK-3 levels (all P<0.05). In
conclusion, curcumin may inhibit JNK-3 phosphorylation to
protect against hippocampal neuron apoptosis after Aβ injection.
Topical Curcumin for Precancer Cervical Lesions
ClinicalTrials.gov July 2017
The purpose of this study is to
see if curcumin can reverse a cervical precancerous state by
looking at people who have the condition and intervening with a
study drug or placebo (an inactive drug), prior to planned
therapeutic loop electrosurgical excision procedure (LEEP) which
is a treatment procedure for removing cervical cancer.
Curcumin induced autophagy anticancer effects on
human lung adenocarcinoma cell line A549
Oncology Letters, July 2017
The anticancer effects of
curcumin on A549 cells can be reduced using autophagy
inhibitors. This suggests a possible cancer therapeutic
application of curcumin through the activation of autophagy.
These findings have improved the understanding of the mechanism
underlying the anticancer property of curcumin.
Food Derived Compounds Block Prostate Cancer Growth
Specialty Pharmacy Times, July 2017
The investigators
identified ursolic acid, a natural chemical found in apple peels
and rosemary; curcumin, a compound in turmeric; and resveratrol,
a natural compound in red grapes or berries, as the most
promising active ingredients and tested them on animal models.
“These nutrients have potential anti-cancer properties and are
readily available,” Tiziani said. “We only need to increase
concentration beyond levels found in a healthy diet for an
effect on prostate cancer cells.” The study also showed that
combining ursolic acid with either curcumin or resveratrol can
prevent cancer cells from accessing crucial nutrients needed to
survive. In other words, through nutrients commonly found in the
human diet, the compounds can block the uptake of glutamine,
which prostate cancer cells need to grow.
Turmeric And Ginger Make My Top Local “Superfood”
Longevity, July 2017
There is literally no nutrient more
effective than curcumin at promoting a healthy inflammatory
response in your brain, heart and body. Multiple studies say
that the spice naturally detoxes the body and supports,
pain-free joints, balanced moods and strong immune systems.
Curcumin even improves metabolic function and reduces the risk
of plaque buildup in the arteries of type-2 diabetes patients.
Lastly it acts as an anti-diabetic and antioxidant in patients
with type-1 diabetes. FYI, studies even say that it’s just as
effective as over-the-counter anti-inflammatory medications.
Moreover that the spice may also be helpful in treating
osteoarthritis, viral and bacterial infections, stomach ulcers,
cancer and other conditions. And because of its antioxidant
properties its even being called “the natural remedy of the
century.”
Curcumin shifts RAS-induced pro-proliferative
MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling,
triggering p53 activation and apoptosis
The American Society for Biochemistry and Molecular Biology,
July 2017
This approach revealed that a curcumin-based
intervention shifts the oncogenic RAS-induced MEK/ERK
pro-proliferative pathway toward p38MAPK/JNK1 pro-death
signaling.
Curcumin pretreatment protects against PM2.5‑induced
oxidized low‑density lipoprotein‑mediated oxidative stress and
inflammation in human microvascular endothelial cells
Molecular Medicine Reports, July 2017
Curcumin induced NF‑κB,
cell adhesion molecule 1 and vascular cell adhesion protein 1
expression. Thus, curcumin treatment may reduce PM2.5‑induced
oxidative stress and inflammation in HMEC‑1. In summary, it was
indicated that the effects of PM2.5 are associated with oxLDL
via the NF‑κB signaling pathway, thereby inducing PM2.5 mediated
oxidative and inflammatory responses. The results also suggested
that curcumin may be able to reduce the oxidative and
inflammatory effects of PM2.5 in HMEC‑1.
Curcumin attenuates hypoxic‑ischemic brain injury in
neonatal rats through induction of nuclear factor
erythroid‑2‑related factor 2 and heme oxygenase‑1
Experimental and Therapeutic Medicine, July 2017
Treatment
with curcumin effectively reduced the brain injury score,
increased myelin basic protein (MBP) expression and increased
the quantity of neuronal cells in neonatal rats with
hypoxic‑ischemic brain injury. Furthermore, treatment with
curcumin significantly attenuated the changes in SOD activity
and MDA levels and suppressed the iNOS protein expression
induced in neonatal rats by hypoxic‑ischemic brain injury.
Treatment with curcumin significantly increased Nrf2 and HO‑1
expression in the neonatal rats with hypoxic‑ischemic brain
injury. The present study indicated that curcumin attenuates
hypoxic‑ischemic brain injury in neonatal rats through the
induction of Nrf2 and HO‑1.
Turmeric and Curcumin: A Primer
Psychology Today, June 2017
According to lab
studies, there is evidence that turmeric curcumin may help both prevent and
treat certain cancers, including: prostate, breast, skin, lung, pancreatic,
and colon cancers.[1,14] It is also useful in the treatment of the symptoms
and inflammation associated with chemotherapy for the treatment of cancer.
(Goel, 2017) There are over 2,000 published studies on the subject, and the
general centire onclusion is that curcumin supplementation may be beneficial for
both cancer prevention and better treatment results.[14] In this sort of
situation, taking pure curcumin extract instead of turmeric is preferred,
because of the dosage requirements for maximum benefit. Many of these
studies in the laboratory have shown that curcumin can actually stop cancer
cells from dividing.[14] Cancer occurs when the DNA in cells get damaged,
which causes them to divide uncontrollably, forming tumors. These can spread
across your body if left untreated.[15] Keeping these cells from
dividing helps stop cancer development in its tracks. Curcumin has also been
shown to trigger programmed cell death, or apoptosis. This is a healthy and
natural way for our bodies to eliminate damaged cells, and it’s helpful for
getting rid of cancer cells. In many ways, curcumin is a good adjunct to
chemotherapy. There have been no reported toxicities associated with
curcumin consumption in this setting, and significant benefit. (Goel, 2017)
For many people, this is an extremely attractive option when dealing with
cancer treatment. Medicinal Uses for Turmeric Curcumin But as impressive as
the results are in those undergoing cancer treatment and chemotherapy; the
medicinal uses of turmeric are broad. It has been shown to alleviate pain
and improve knee functioning in patients with osteoarthritis.[1] Many people
suffer from arthritis, which involves inflammation of the joints. It can
cause not only pain and swelling, but also limited mobility.[16] A study of
107 participants found that curcumin had roughly the same effect on patients
as ibuprofen.[17] Turmeric is also able to assist in maintaining a healthy
digestive tract as well. Its medicinal properties help regulate healthy
digestion. Turmeric is especially effective against diarrhea from many
causes, including infection, or inflammatory diseases like irritable bowel
syndrome (IBS) or inflammatory bowel disease (IBD) like Crohn’s disease or
ulcerative colitis. One study on turmeric’s effect on ulcerative colitis
showed that patients who consumed turmeric curcumin had significantly lower
relapse rates than patients who did not consume it. This was a double-blind
placebo-controlled study, which is the gold standard of clinical study
design and methods; and one of the most reliable scientific ways to gather
scientifically valid information.[24] Another sign of turmeric curcumin’s
major health benefits is the fact that rural India’s population houses the
lowest rates of Alzheimer’s disease (AD) in the entire world.[32] Adults in
India are 4.4 times less likely to develop AD than comparably aged cohorts
in other industrialized countries. Epidemiological and animal studies
suggest an important role for turmeric and curcumin in potential prevention
and treatment of neurodegenerative diseases like Alzheimer’s disease.
(Ringman, Frautschy, Cole, Masterman, & Cummings, 2005, ) (Sikora,
Scapagnini, & Barbagallo, 2010)
Curcumin induces apoptotic cell death in human pancreatic cancer
cells
Oncology Letters,
June 2017 The natural compound curcumin has previously been reported to
inhibit pancreatic cancer cell growth. miR‑340 was identified to be
significantly upregulated following curcumin treatment. In addition,
treatment with curcumin or miR‑340 induced pancreatic cancer cell apoptosis,
whereas silencing endogenous miR‑340 significantly inhibited the
proapoptotic effect of curcumin. Furthermore, curcumin treatment
significantly reduced XIAP expression, an effect that was rescued by
treatment with anti‑miR‑340. The results of the present study suggest that
the miR‑340/XIAP signaling pathway is a downstream target of curcumin that
mediates its proapoptotic effects on pancreatic cancer cells. This may
provide the basis for novel treatment strategies for patients with
pancreatic cancer.
Curcumin induces apoptotic cell death and protective autophagy
in human gastric cancer cells
Oncology Reports, June 2017
Curcumin
possesses an anticancer effect against a wide assortment of tumors with
selective cytotoxicity for tumor cells. Our results demonstrated that
curcumin inhibited the viabilities of gastric cancer cell lines BGC-823,
SGC-7901 and MKN-28 in both a time- and dose-dependent manner. In addition,
curcumin treatment induced gastric cancer cell apoptosis in a
dose‑responsive manner. Western blotting of apoptosis‑related proteins
further confirmed the pro-apoptotic potential of curcumin. After exposure to
curcumin, a robust induction of autophagy was observed in gastric cancer
cells, which was characterized by the formation of acidic vesicular
organelles (AVOs), conversion of LC3-I to LC3-II and an increase in the
levels of autophagy‑related proteins. Activation of the PI3K/Akt/mTOR
signaling pathway was suppressed in gastric cancer cells with curcumin
treatment. Collectively, our findings provide new evidence that curcumin
induces apoptotic cell death and protective autophagy in human gastric
cancer cells in vitro. Autophagy inhibitor treatment may provide a novel and
effective strategy for improving the anticancer effect of curcumin against
gastric cancer.
Turmeric (Curcumin),The Healing Root
blastingnews.com June 2017
Curcumin or
curcuma longa, is a powerful antioxidant, adaptogen, antiviral,
antibacterial, anti inflammatory, anti carcinogen and contains many
beneficial vitamins and minerals including zinc, protein, niacin, fibre,
vitamin C, vitamin E, vitamin K, iron and magnesium. Turmeric according to
over 6000 #Peer Reviewed scientific studies, is beneficial for all sorts of
ailments including inflammation, skin disorders, gastrointestinal disorders
such as IBS, arthritis, viral infections, nausea, hormonal imbalances,
obesity, hypertension, glaucoma, Helicobacter pylori, diabetes, high
cholesterol, cancer and depression.
Antitumor effects of curcumin in human bladder cancer in vitro
Oncology Letters, June 2017
Curcumin was
identified to decrease the growth of T24 and 5637 cells in a dose‑ and
time‑dependent manner. The present study confirmed that curcumin is able to
inhibit cell migration and promote apoptosis of bladder cancer through
suppression of matrix metalloproteinase signaling pathways in vitro. The
anticancer effects of curcumin on bladder cancer cells may benefit clinical
practice in the future.
JNK pathway mediates curcumin-induced apoptosis and autophagy in
osteosarcoma MG63 cells
Experimental and Therapeutic Medicine, June 2017
In the current study, it
was determined that curcumin was able to significantly induce apoptosis, and
lead to autophagy in MG63 cells. Notably, inhibition of apoptosis enhanced
curcumin‑induced autophagy due to upregulation of the c‑Jun N‑terminal
kinase (JNK) signaling pathway. This finding was confirmed by the use of
JNK‑specific inhibitor, SP600125. Furthermore, our data showed that
curcumin‑induced apoptosis was increased when autophagy was completely
inhibited by 3‑methyladenine in MG63 cells. These results suggest that
autophagy may have an important role in resistance to apoptosis when MG63
cells are incubated with curcumin. Thus, these results provide important
insights into the interaction between apoptosis and autophagy in
osteosarcoma cells and clinical treatment strategies using curcumin.
Compound in turmeric found to suppress viruses, including
hepatitis, herpes, chikungunya, influenza-A, HIV and HPV
Natural News, June 2017
The turmeric compound
curcumin was found to effectively suppress a large number of viruses, recent
studies showed. The compound was previously known to defer cancer growth,
resolve Lichen Panus, reduce type-2 diabetes and prevent Alzheimer’s disease
and dementia onset. However, a new article published in GreenMedInfo.com
listed several other studies indicating that the compound was able to
inhibit the growth of a plethora of viruses including zika virus, hepatitis,
herpes, chikungunya virus, influenza-A, HIV and HPV. Curcumin was found to
affect the virus; ability to bind with other cells. Another study published
in the journal Gut showed that curcumin hindered the hepatitis C virus from
entering the human liver cells. According to the researchers, this effect
proved especially beneficial — as exposure to the HCV virus caused severe
liver disease and was known to affect more than 160 million people around
the world. Membrane fluidity experiments indicated that curcumin affected
the fluidity of the HCV envelope resulting in impairment of viral binding
and fusion. Curcumin has also been found to inhibit cell-to-cell
transmission and to be effective in combination with other antiviral
agents," the researchers concluded. Turmeric compound impedes more viruses
Curcumin was also known to suppress the influenza-A virus in a number of
studies. Researchers at the Graduate Institute of Microbiology and Public
Health at the National Chung Hsing University in Taiwan found that the
turmeric compound interfered with the virus' haemagglutination activity by
blocking its ability to bind with red blood cells in patients. In addition,
a study published in the Italian Journal of Biochemistry revealed that
curcumin prompted hemeoxygenase-1 gene stimulation in the hippocampus of the
brain. In turn, this activation triggered the production of bilirubin, a
potent antioxidant essential for the immune system’s health. According to
researchers at the Michigan State University, curcumin inhibited the herpes
virus from spreading by affecting its early gene expression. “Curcumin is a
potent compound with various biological properties. We have shown that
curcumin significantly affects HSV-1 IE gene expression which thereby
diminishes the ability of the virus to launch the lytic infectious cycle,”
the researchers wrote. A study published in the Asia Pacific Journal of
Cancer Prevention also found that curcumin was able to clear human
papillomavirus in women. As part of the study, researchers at the
Chittaranjan National Cancer Institute in India examined 287 HPV-positive
women. The experts noted that women who were given curcumin-based treatments
had HPV clearance rates between 81 percent and 87 percent.
Effective Natural Pain Relief for Fibromyalgia
nationalpainreport.com June 2017
More
recently researchers have called curcumin, the active ingredient in
turmeric, the “herbal ibuprofen.”
[https://www.ncbi.nlm.nih.gov/m/pubmed/7390600/] One study found that
curcumin was actually more effective at reducing pain and swelling in
arthritic joints than anti-inflammatory medications.
[http://onlinelibrary.wiley.com/doi/10.1002/ptr.4639/abstract;jsessionid=A768F9AF39A7EE0BC525EC80EC1A6861.f04t04]
Curcumin touted for metabolic benefits in people with fatty
liver disease: RCT data
Drug Research, June 2017
Curcumin is a dietary polyphenol with
lipid-modifying, antioxidant and anti-inflammatory properties.
Supplementation with curcumin was associated with a reduction in body mass
index (−0.99±1.25 vs. − 0.15±1.31 in the curcumin and placebo groups,
respectively; p=0.003) and waist circumference (−1.74±2.58 vs. −0.23±3.49 in
the curcumin and placebo groups, respectively; p=0.024). Ultrasonographic
findings were improved in 75.0% of subjects in the curcumin group, while the
rate of improvement in the control group was 4.7% (p<0.001). Serum levels of
aspartate aminotransferase and alanine aminotransferase were reduced by the
end of trial in the curcumin group (p<0.001) but elevated in the control
group (p<0.001). Curcumin was safe and well tolerated during the course of
trial. Short-term supplementation with curcumin improves liver fat and
transaminase levels in patients with NAFLD.
Curcumin
Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory
Damage
Nutrients, June 2017
Curcumin, the active substance of Curcuma longa which is attributed most of
the beneficial properties of turmeric, is chemically classified among the
polyphenols. The many beneficial properties attributed to curcumin, as
antioxidant, anti-inflammatory, anti-infective, anti-tumor, and preventive
agent, are closely correlated with each other and could be associated with
the ability to modulate the molecules involved in inflammation, programmed
cell death, and morphology.In the present work, we demonstrated that
pre-treatment with curcumin is able to reduce the levels of apoptosis in
intestinal epithelial cells exposed to IFNγ.
Can turmeric help manage diabetes? What the evidence says
WXYZ Detroit, June 2017
Research focuses on
the main component of turmeric called curcumin. A review of 13 years of
research suggest curcumin may help in different ways. Adding it to your diet
may reduce your chance of developing diabetes as curcumin appears to improve
the cells that create insulin in the pancreas. Taking curcumin orally may
reduce blood sugar levels, however more research is needed in humans. Other
studies have shown those with prediabetes may not develop full diabetes when
taking curcumin in capsule form.Taking curcumin may also help to prevent
diabetic-related nerve damage, prevent diabetic cataracts and kidney
disease.
Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in
dextran sulfate sodium-induced colitis
Nature.com June 2017
Curcumin exerts
anti-inflammatory effects in DSS-induced colitis
Turmeric: From humble root to golden goddess
Vancouver Sun, June 2017
The active ingredient, curcumin has also been
investigated by western science as a cancer-fighting agent. Studies have
shown that curcumin is an anti-cancer agent and an anti-inflammatory. It
inhibits an enzyme called COX-2 that is activated in various inflammation
cascades. It works similarly to non-steroidal anti-inflammatory drugs.
Anticancer effect of curcumin
inhibits cell growth in breast cancer cell
Oncology Letters, May 2017
Curcumin is a polyphenol extracted from turmeric, which that belongs to the
Zingiberaceae family. Curcumin has numerous effects, including
anti-inflammatory, antitumor, anti‑oxidative and antimicrobial effects.
Curcumin inhibited cell viability and induced cytotoxicity of MCF‑7 cells in
a concentration‑ and time‑dependent manner, by inducing apoptosis and
increasing caspase‑3/9 activities. In addition, curcumin downregulated
miR‑21 expression in MCF‑7 cells by upregulating the PTEN/Akt
signaling pathway. The present study has for the first time, to the best of
our knowledge, revealed the anticancer effect of curcumin in suppressing
breast cancer cell growth.
How Turmeric Shows Great Promise as
a Natural Remedy for the Prevention and Healing of Symptoms of Type 2
Diabetes
EmaxHealth,
May 2017 The science on curcumin, an Indian spice and anti-inflammatory
has shown promise in reducing and even preventing complication of diabetes
with it's effects on insulin resistance and by regulating blood sugar. The
systematic review published in the peer-reviewed journal, Evidence-Based
Complementary and Alternative Medicine looked at curcumin and its effect on
diabetes in the prevention and treatment of diabetes and its associated
disorders. The review concluded that curcumin could favorably affect most of
the leading aspects of diabetes, including insulin resistance,
hyperglycemia, hyperlipidemia, or high concentrations of lipids in the
blood, and islet apoptosis and necrosis, or organ failure. In addition,
curcumin showed promise in preventing the injurious complications of
diabetes.
Postnatal treatment using curcumin
supplements to amend the damage in VPA-induced rodent models of autism
Complementary and Alternative Medicine, May 2017
Curcumin plays a
significant therapeutic role in attenuating brain damage that has been
induced by prenatal VPA exposure in rats; however, its therapeutic role as a
dietary supplement still must be certified for use in humans.
Curcumin: A naturally occurring
modulator of adipokines in diabetes
Journal of Cellular Biochemistry, May 2017
Curcumin, the bioactive component of turmeric, has been used for the
treatment of several diseases including diabetes and its complications.
Additionally, we examine the potential beneficial effects of the activity of
curcumin in the prevention and treatment of diabetes.
This Could Be The Greatest Spice For
Men's Health
Huffingtonpost.com May 2017
Curcumin extracts have been shown to reduce
the pain and improve function in knee osteoarthritis “with an efficiency
equivalent to ibuprofen, but with fewer gastrointestinal side effects.”
Combining curcumin and Boswellia serrata also has been shown to be more
effective than the COX-2 inhibitor celecoxib in the treatment of
osteoarthritis.A number of studies have found that turmeric/curcumin is
effective in reducing depression, especially mild cases. One study noted
that patients with major depressive disorder who took curcumin fared just as
well as their peers who took Prozac (fluoxetine). A more recent
meta-analysis of six clinical trials reported that curcumin “appears to be
safe, well-tolerated, and efficacious among depressed patients.” Curcumin
has been shown to improve glucose tolerance in animal research as well as
significantly lower hemoglobin A1c in patients with type 2 diabetes.
Free-radical fighting antioxidants called curcuminoids are abundant in
turmeric. Curcumin is the most prominent of these polyphenols. In addition
to helping destroy disease-causing free radicals, curcuminoids also
facilitate the activity of antioxidant enzymes (e.g., catalase, superoxide
dismutase). Antioxidants can help slow the aging process, protect against
chronic disease (including cancer and heart disease), reduce oxidative
stress, and fighting inflammation.
Healing The Body, Naturally
Elle Magazine, May 2017
There is good research to support the ability of
curcumin to reduce cellular damage and risk of chronic disease; decrease
pain and inflammation (effects have been shown to be similar to
paracetamol); [and] it may reduce the risk of heart disease. Curcumin intake
is also associated with a decreased risk of colon cancer and reduced
symptoms associated with ulcerative colitis.
Curcumin sensitizes prostate cancer
cells to radiation
J
Drug Target, May 2017
Curcumin has been reported as a radiosensitizer in
prostate cancer. Curcumin sensitizes prostate cancer cells to radiation
partly via epigenetic activation of miR-143 and miR-143 mediated autophagy
inhibition.
Turmeric: The Golden Herb
Hamlet Hub, May 2017
Anti-inflammatory: the constituent curcumin is
responsible for the anti-inflammatory action thus reducing inflammation and
making it useful in the treatment of muscle pain, joint pain, arthritis,
fibromyalgia, ulcerative colitis, Chrohn’s disease, rheumatoid arthritis,
cancer, irritable bowel syndrome (IBS), headaches, SLE, bronchitis,
autoimmune diseases, cardiovascular diseases. Anti-oxidant: curcumin can
protect the DNA against breaks and oxidation which makes it useful in the
treatment of different types of cancer, autoimmune diseases, cardiovascular
health, protective for the body. Anti-neoplastic: curcumin has been proven
to have anti-cancer properties in the body. Either as part of a treatment
protocol or as preventative. Lipid modulation: curcumin has shown positive
results in decreasing total plasma cholesterol levels, decreasing LDL,
decreasing triglycerides and increasing HDL levels. It also helps decrease
inflammation in the vessels hence improving cardiovascular health and
decreasing risks. Anti-platelet: curcumin has been shown to prevent thrombus
formation from platelet aggregation hence being beneficial for
cardiovascular health. Anti-bacterial: curcumin has also shown effectiveness
with treating infections. Anti-hepatotoxic: curcumin has been shown to
stimulate Phase II detox activity in the liver helping excrete toxins out of
the body.
New Prospects for Treating Malignant
Mesothelioma with Curcumin
SurvivingMesothelioma.com May 2017
There is more evidence that the active
ingredient in turmeric may have the power to help combat malignant
mesothelioma. A new French study on curcumin finds that the compound not
only slowed the growth of one of the rarest types of mesothelioma tumor
cells in the laboratory but also reduced total tumor mass in lab rats in
just two weeks. Curcumin, the plant polyphenol that gives turmeric its
yellow hue and pungent flavor, has been the subject of numerous malignant
mesothelioma studies in recent years, in part because of its powerful
anti-inflammatory properties. In addition, curcumin appeared to attract
cancer-fighting CD8+ T lymphocytes to the area which clustered around small
residual mesothelioma tumors in the peritoneal cavity after treatment.
“These data open up interesting new prospects for the therapy of sarcomatoid
mesothelioma with curcumin and its derivatives,” concludes Dr. Pouliquen.
Earlier this year, scientists in the Department of Experimental Medicine at
the University of Rome conducted a similar experiment and that found that
intraperitoneal curcumin extended survival in mice with mesothelioma. In
2015, mesothelioma researchers with Flinders University in Australia
determined that curcumin had the ability to keep mesothelioma tumors from
giving rise to their own new blood vessels. That study suggested that
curcumin could become a supplemental treatment for certain mesothelioma
patients.
Why are so many scientists studying
this spice?
Stuff,
May 2017 Curcumin is also an antioxidant which helps prevent free radical
damage -studies have found that people with depression have greater free
radical damage to brain cells. Curcumin appears to help protect brain cells
- which is why other studies are looking at whether curcumin might help
prevent dementia. There's a huge demand for an anti-inflammatory substance
that doesn't have side effects and curcumin stands out. More than 60 studies
of curcumin worldwide are looking at its potential role with a number of
cancers.
Curcumin improves bone density by up
to 7%, study reveals
Daily Mail, May 2017
A compound in turmeric, known as curcumin, is
thought to balance out cells that remove ageing parts of bone before it is
replaced, according to previous findings. Curcumin blocks rogue proteins
called beta amyloid, which clump together and destroy neurons, according to
researchers from Edith Cowan University, Perth. In the study 96 participants
aged between 40 and 90 were given either a daily placebo or 1,500 mg of
curcumin for 12 months. In tests of verbal and memory skills, those taking
the dummy pill suffered a decline in mental function after just six months
that was not observed in those having curcumin.
Curcumin exerts antitumor activity
OncoTargets and Therapy, May 2017
Curcumin, a natural polyphenol
compound, exhibits tumor suppressive activity in a wide spectrum of cancers,
including nasopharyngeal carcinoma cells. Curcumin upregulated the
expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target.
Our results identified that upregulation of miR-7 by curcumin could benefit
nasopharyngeal carcinoma patients.
Curcumin, Found in Turmeric Plants,
Seen to Shrink Sarcomatoid Mesothelioma Tumors in Rat Study
MesotheliomaResearchNews.com May 2017
When curcumin was administered to
rats one week after the injection of tumor cells, the size of the tumors
dropped dramatically by the 16th day. The researchers also found that
curcumin appeared to stimulate the immune system, observing a type of white
blood cell surrounding remaining tumors in rats treated with curcumin. This
white blood cell, known as a CD8+ T-cell, is known to kill cancer cells
under the right conditions. “In conclusion, these data open up interesting
new prospects for the therapy of malignant mesothelioma with curcumin, in
particular the sarcomatoid subtype,” the research team wrote. “Future
studies will determine the best sequence/dose(s) of curcumin or its many
derivatives to use to optimize the specific immune response directed against
M5-T1 cells. A complementary approach would also be the combination of
curcumin/derivatives with current chemotherapeutic agents to reduce the dose
used and the associated systemic toxicity of the latter.”
Superfood focus: Healthy properties
give turmeric a golden touch
The National, May 2017
The benefits are primarily due to curcumin, the
active compound in turmeric that is not only responsible for its bright hue,
but also a powerful antioxidant with anti-inflammatory and antibacterial
qualities.
Turmeric may help ease the symptoms
of Lyme disease
EmaxHealth,
May 2017 The secret is turmeric’s curcumin, a plant chemical that has
many healing capabilities, and has been scientifically proven to counter
skin rashes, fatigue, bacterial infections and pain in joints and muscle,
all of which are symptoms of Lyme disease. Research has proven that
curcuminoids can improve the pain and physical function of patients
suffering from knee osteoarthritis, an extremely debilitating and painful
disease that is characterized by the degeneration of joint cartilage and the
underlying bone causing inflammation. In an animal model study on
immunologically induced fatigued mice, scientists were able to observe that
oral administration of curcumin, reduced oxidative stress, increased in
mobility ( mice were less tired), and also reduced abnormal sensitivity to
pain. Curcumin protects skin by quenching free radicals and reducing
inflammation through nuclear factor-KB inhibition. A study trying to
establish the effectiveness of curcumin against 4 types of bacteria, namely
Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and
Pseudomonas aeruginos, has confirmed that turmeric is effective against all
the bacterias tested and the extent of bacteria killing showed an increase
with dosage and incubation time.
Anti-inflammatory effect of combined
tetramethylpyrazine, resveratrol and curcumin in vivo.
BMC Complementary and Alternative Medicine, May 2017
Resveratrol and
curcumin, as natural flavones products, have good therapeutic effect in
acute and chronic inflammation; on the other hand, tetramethylpyrazine (TMP)
has angiogenesis and vessel protection effect as well as anti-inflammatory
function. In this paper, the anti-inflammatory effect of the
tetramethylpyrazine, resveratrol and curcumin (TRC) combination in acute and
chronic inflammation was reported in vivo.
Curcumin Inhibits Apoptosis of Chondrocytes
Nutrients, May 2017
Osteoarthritis (OA) is an inflammatory disease of
load-bearing synovial joints that is currently treated with drugs that
exhibit numerous side effects and are only temporarily effective in treating
pain, the main symptom of the disease. Curcumin, the principal curcuminoid
and the most active component in turmeric, is a biologically active
phytochemical. Evidence from several recent in vitro studies suggests that
curcumin may exert a chondroprotective effect through actions such as
anti-inflammatory, anti-oxidative stress, and anti-catabolic activity that
are critical for mitigating OA disease pathogenesis and symptoms. Curcumin
should be explored further for the prophylactic treatment of osteoarthritis
in humans and companion animals.
Curcumin suppresses cell growth and
invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma
cells
Oncotarget,
May 2017 Studies have demonstrated that curcumin exerts its tumor
suppressor function in a variety of human cancers including glioma. Curcumin
significantly inhibited cell growth, suppressed cell migration and invasion,
induced apoptosis and cell cycle arrest in glioma cells. Curcumin exerts its
antitumor activity through inhibition of Skp2 pathway. Collectively, our
findings suggest that targeting Skp2 by curcumin could be a promising
therapeutic approach for glioma prevention and therapy.
Evaluation of intracavitary
administration of curcumin for the treatment of sarcomatoid mesothelioma.
Oncotarget,
May 2017 The treatment of tumor-bearing rats with 1.5 mg/kg curcumin on
days 7, 9, 11 and 14 after tumor challenge dramatically reduced the mean
total tumor mass at day 16. .These data open up interesting new prospects
for the therapy of sarcomatoid mesothelioma with curcumin.
Efficacy of curcumin in inducing apoptosis and
inhibiting the expression of VEGF in human pterygium fibroblasts
International Journal of Molecular
Medicine, April 2017
Curcumin suppress cell proliferation in the
pterygium by inducing HPF apoptosis and inhibiting VEGF expression. Thus,
curcumin has potential for use as a novel agent for the treatment of
pterygium in the near future.
History and Origins of Turmeric
DESIblitz, April 2017
Elderly villagers in India appear to have the
lowest rate of Alzheimer’s disease in the world, and researchers have
speculated that the anti-inflammatory effects of curcumin may be partly
responsible,” states Dr Andrew Weil. Curcumin may kill and prevent
cancer cells of the breast, bowel, stomach and skin from growing. Curcumin
also acts as an antioxidant, which protects the body from free radical
damage (free radicals contribute to increased cancer risk). Curcumin
can help sustain healthy blood pressure. This ultimately, promotes heart
health and reduces the likelihood of developing heart disease. The spice may
also prevent the clogging of arteries, which is a risk factor for strokes
and heart attacks. Curcumin also seems to reduce the risk of developing
diabetes among pre-diabetic individuals.
Medicinal Herbs for Cancer
Liberty Voice, April 2017
Curcumin, in turmeric, is a powerful
anti-inflammatory agent. Additionally, it contains broad anti-parasitic and
antimicrobial features. Turmeric has properties to support the fight against
cancer by preventing cells from dividing quickly to form tumors, and
prevents the development of capillaries that feed tumors. The active
ingredient in turmeric, curcumin, kills diseased cells without damaging the
healthy cells. It does this by removing the activation path of most diseases
caused by inflammation, which is linked to cancer. Turmeric is effective in
preventing cancer of the stomach, lung, colon, breast, and skin.
Curcumin and Lycopene or Bixin in
Yoghurt on Inhibition of LDL Oxidation
School of Pharmaceutical Sciences, São Paulo
State University, April 2017
Treatments with mixtures of curcumin and
lycopene or bixin had combined effects, decreasing biomarkers of
carbohydrate and lipid disturbances (curcumin effect), increasing the HDL
levels (carotenoids effects) and mitigating oxidative stress (curcumin and
carotenoids effects). The combined effects also led to prevention of the LDL
oxidation, thereby mitigating the cardiovascular risk in diabetes. These
findings provide evidence for the beneficial effect of curcumin and
carotenoid mixtures as a supplementation having antioxidant and
antiatherogenic potentials, thus appearing as an interesting strategy to be
studied as a complementary therapy for diabetic complications.
Proven Health Benefits of Turmeric and Dosage
Belair Daily, April 2017
Turmeric has a powerful active ingredient called
curcumin that is known to be a natural antioxidant and has been used for
generations as a treatment for digestive and liver problems. Now, turmeric
and diabetes have been linked through several studies.
Foods that flush the body
JamaicaObserver.com April 2017
Curcumin is a component that stimulates the
production of bile by the gall bladder. Bile is used by the kidneys, not
just to eliminate toxins, but also to restore and revitalise liver cells
that are central to the deconstruction of harmful compounds.
The science on curcumin
Mind Body Green, April 201
Curcumin is a powerful antioxidant within
turmeric and the center of most of the research about turmeric. Because of
the evidence of curcumin's powerful anti-inflammatory benefits, it's
extracted and standardized in higher doses to be put into supplements.
What's the science on curcumin? The commonality between just about all the
research done on turmeric and curcumin boils down to one thing:
inflammation. Inflammation is a buzzword of late and something we have
talked about in functional medicine for years. Curcumin and turmeric are
known for their ability to tame chronic inflammation; here's a roundup of
health problems for which they seem to be beneficial: Alzheimer's Autoimmune
inflammation Brain inflammation (brain fog and memory loss) Cancer Candida
Cataracts Depression Diabetes Erectile dysfunction Gallbladder problems
Heavy metal toxicity Inflammatory bowel disorders Insulin resistance Lupus
Pneumonia Rheumatoid arthritis Viral infections Weight-loss resistance.
10 Ways Turmeric Might Be Superior To Modern
Medicine
The Alternative Daily, April 2017
The active compound in turmeric — curcumin — is
on par with over-the-counter anti-inflammatories, without all the harmful
side effects. In one study, researchers tested stressed-out lab rats
displaying depression-like symptoms along with adrenal issues, caused by a
prolonged elevation in stress hormones. Surprisingly, they found that
curcumin helped to alleviate negative physiological effects. “These results
provide compelling evidence that the behavioral effects of curcumin in
chronically stressed animals, and by extension humans, may be related to
their modulating effects on the HPA axis and neurotrophin factor
expressions,” wrote the authors. Several studies have found that curcumin
can significantly inhibit the development and movement of cancer cells
through the body. It does this by reducing the growth of new blood vessels
in tumors, called angiogenesis. Curcumin may also contribute to the cancer
cell death directly.
Anti-inflammatory efficacy of turmeric oil and
curcumin in colitis
Nature.com April 2017
Considering that curcumin is a readily
available, safe and a cost-effective botanical, there is a growing interest
in exploring its clinical efficacy individually or as an adjunctive
treatment for managing and/or treating UC and subsequently improving the
overall quality of life for patients with this inflammatory disease.
Although curcumin is a well-established anti-inflammatory agent, the exact
mechanism(s) by which it attenuates inflammatory burden in diseases such as
UC remains unclear. Herein, we demonstrated that curcumin exhibited
significant anti-inflammatory effects in a mouse model of dextran sodium
sulfate (DSS)-induced colitis.
Go for the gold with turmeric
SC Now, April 2017
Turmeric contains a phytochemical nutrient named
curcumin, which is an antioxidant known for anti-inflammatory,
anti-microbial and anti-cancer properties. With more than 100 clinical
studies, curcumin has been shown to be active against several chronic
diseases, including various types of cancers, diabetes, obesity,
cardiovascular, pulmonary, neurological and autoimmune diseases, such as
inflammatory bowel disease.
Superherbs
Rescue, April 2017
Turmeric contains Curcumin as the main active
ingredient, which has antioxidant and anti-inflammatory properties. As an
anti-inflammatory curcumin is powerful, matching the effectiveness of some
drugs. Low level inflammation is involved in almost every chronic condition;
cancer, Alzheimer’s, metabolic syndrome as examples. Curcumin actually
targets the inflammatory pathway at a molecular level. In addition to
protecting against free radical damage (antioxidant) and chronic
inflammation (anti-inflammatory), curcumin has shown promise in treating
depression and could be considered an anti-ageing supplement.
Clinical Use of Curcumin in Depression: A
Meta-Analysis
Journal of the American Medical Directors
Association, March 2017
Six clinical trials with a total of 377 patients
were reviewed, comparing the use of curcumin to placebo. In patients with
depression, the pooled standardized mean difference from baseline Hamilton
Rating Scale for Depression scores (pooled standardized mean difference
−0.344, 95% confidence interval −0.558 to −0.129; P = .002) support the
significant clinical efficacy of curcumin in ameliorating depressive
symptoms. Significant anti-anxiety effects were also reported in 3 of the
trials. Notably, no adverse events were reported in any of the trials. Most
trials had a generally low risk of bias, except for an open trial of
curcumin and a single-blinded study.
10 Health Benefits Of Turmeric And Curcumin You
Need To Know
Global Health Clinics, March 2017
Curcumin has been shown to reduce inflammation
by lowering levels of two inflammation enzymes in the body. Inflammation is
a complicated immunological process that takes places in the cell. Curcumin
works at a cellular level to block out bioactive molecules that trigger the
inflammation process common in most chronic diseases such as arthritis and
gastrointestinal disorders. One of the mechanisms behind ageing and many
diseases is oxidative damage. Curcumin is a potent antioxidant that can
neutralize free radicals in the body helping to prevent aging and disease.
It can also stimulate the body’s own antioxidant properties. Brain derived
neurotrophic factor (BDNF) is a type of growth hormone that functions in the
brain. Curcumin has been shown to increase neurogenesis, potentially via
modulation of the hypothalamic-pituitary-adrenal (HPA) axis and by
increasing (BDNF) production in the brain. Depression has been linked to
reduced levels of BDNF. Studies have confirmed that curcumin, found in
turmeric, has a similar effect as antidepressants on patients suffering from
depression by boosting levels of BDNF. Curcumin has also been shown to boost
the brains neurotransmitters serotonin and dopamine. Due to its high
antioxidant and anti-inflammatory properties curcumin can lower the chance
of heart diseases. Curcumin improves the lining of the blood vessels,
regulate blood pressure and reduce blood clotting. One study found that
curcumin is just as effective as exercise at improving blood flow to the
heart. Curcumin contains anti-cancer compounds that can strengthen the body
providing cancer protection. Given that curcumin is a potent
anti-inflammatory, it makes sense that it could help with arthritis as it
has a positive effect on joint swelling and pain-reduction. Some studies
suggest that patients with rheumatoid arthritis, curcumin was even more
effective than an anti-inflammatory drug.Curcumin is known for its
anti-inflammatory properties that can pass through the blood/brain barrier,
unlike other substances and has been shown to lead to various improvements
in the pathological process of Alzheimer’s disease. Due to all of curcumins
potent health benefits listed above such as reducing inflammation in the
body and being a potent antioxidant curcumin provides compounds that kill
off free-radicals that cause the ageing process and prevent disease.
Spice Compound Extends Mesothelioma Survival in
Mice
Surviving Mesothelioma, March 2017
Curcumin has been the subject of numerous
mesothelioma studies. The latest one, conducted by scientists at the
Department of Experimental Medicine at the University of Rome, finds that
the compound has the power to not only kill mesothelioma cells in the lab,
but to also extend survival in mice infected with the asbestos cancer.
The ancient wisdom of turmeric
Lacrosse Tribune, March 2017
“Curcumin is the compound in turmeric that gives
it its bright yellow hue,” says Rachael Hartley, R.D., L.D., C.D.E. It has
been shown to block enzymes in the inflammatory pathways, potentially
fighting inflammation at the molecular level, and it’s being actively
studied for relief of swelling and pain in both osteoarthritis and
rheumatoid arthritis. Curcumin is also a powerful antioxidant, and lab and
animal studies have reported that curcumin inhibits cancer at multiple
stages of development, although we don’t yet know how that might work in the
body. The anti-inflammatory and anti-oxidant effects could help reduce heart
disease risk, and this potent turmeric component also may help keep the
lining of veins and arteries healthy and reduce cholesterol levels.
Curcumin induces apoptosis and protective
autophagy in castration-resistant prostate cancer cells through iron
chelation
Drug Design, Development and Therapy, March 2017
Curcumin induces apoptosis and autophagy in
different cancer cells. Moreover, chemical and biological experiments have
evidenced that curcumin is a biologically active iron chelator and induces
cytotoxicity through iron chelation. Our results indicate that curcumin
induces apoptosis and protective autophagy in CRPC cells.
Turmeric’s anti-aging effects
EmaxHealth, March 2017
Recent studies have observed in animal and human
trials that Turmeric’s natural chemical knows as Curcumin, (the yellow
pigment from the rhizoma of Curcuma longa), exerts powerful anti-oxidant,
photo-protective and anti - inflammatory activities. This leads scientists
to believe that curcumin has anti-ageing effects. A review of the literature
on the effects of Curcumin in the body, published by the journal of
alternative medicine, found that a high dose of Curcumin is not toxic for
humans. In one of the studies 25 subjects used up to 8000 mg of curcumin per
day for 3 months, and five other subjects used 1125-2500 mg of curcumin,
which was also found to be safe. There are three main aspects of ageing:
oxidative stress, inflammation and sun damage. Experts at the Deparment of
Neuroscience and Neurology in Finland, explain that during aging, adaptive
immunity significantly declines, while innate immunity seems to be activated
which induces a characteristic pro-inflammatory profile. The first way in
which Turmeric works is by inhibiting the number of different molecules that
play a role in inflammation. In 2010 an article published at Current Design,
has measured the molecular targets of curcumin in the body. The researchers
found that that curcumin directly affects a few major targets, such the
NF-κB signaling pathways, which can in turn suppresses the pro-inflammatory
state involved in the etiology of ageing and age-related diseases.
Therefore, Curcumin’s anti- ageing results are compelling.
Curcumin blocks autophagy and activates
apoptosis of malignant mesothelioma cell lines and increases the survival of
mice
Oncotarget, March 2017
Curcumin is a "multifunctional drug".
Intraperitoneal administration of curcumin increased the median survival of
C57BL/6 mice intraperitoneally transplanted with #40a cells and reduced the
risk of developing tumors. Our findings may have important implications for
the design of MM treatment using curcumin.
Turmeric is effective in treating various types
of cancer
Kashmir Monitor, March 2017
Curcumin, the principal curcuminoid of turmeric,
has been intensely studied as a cancer protective agent. Its potential has
been tapped in head and neck cancers, breast, lung, gastro-intestinal
cancer, ovarian cancer, melanoma, neurological cancers, sarcoma, leukemias
and lymphoma.
Compound in Turmeric Shows Promise for Treating
Mesothelioma
Mesothelioma.com, March 2017
Curcumin, a compound in the spice turmeric, has
shown promise as a possible treatment for malignant mesothelioma. A recent
study discovered the compound blocked intracellular degradation and
activated the death of mesothelioma cells. Plus, it increased the survival
of mice given the mesothelioma cell line.
Benefits of Turmeric
Verge Campus, March 2017
The compound curcumin is naturally occurring in
turmeric, and it is responsible for the many benefits of the plant. However,
curcumin makes up only around 3% of the make-up of turmeric by weight. For
that reason, supplements are the best way to get curcumin in your system.
Curcumin is proven to reduce chronic inflammation, helping to prevent its
negative long-term effects. Curcumin happens to be a powerful antioxidant,
capable of neutralizing free radicals. Curcumin also stimulates the
production of our body’s own natural antioxidant enzymes.Studies have shown
that curcumin can help prevent cancerous cells from growing, multiplying,
and spreading. It has even been found to kill some cancerous cells. For
example, in a study of 44 men with lesions in the colon, which could
possibly turn cancerous, curcumin was administered. The men were given 4
grams of curcumen per day for 30 days. At the end of the trial, the amount
of lesions had decreased by 40%. A controlled study took 60 patients and
divided them into three groups. One group was given Prozac, the other Prozac
and curcumin, and the third just curcumin. The purely curcumin group
experienced positive benefits, but the most effective treatment was found in
the combination of Prozac and Curcumin.In a study, patients with rheumatoid
arthritis experience better results from taking curcumin supplements as
opposed to arthritis medication. This is likely due to curcumin’s
anti-inflammatory properties The active chemical in turmeric, curcumin, is a
wonder-molecule. Its many uses testify to its presence in human culture and
Ayurvedic traditions dating back thousands of years. Its potentials are
continuing to be studied, so that in the future we may learn even more about
this magical molecule.
Exploration of inhibitory mechanisms of curcumin
in lung cancer metastasis using a miRNA- transcription factor-target gene
network
Public Library of Science (PLOS) , March 2017
The present study was aimed to unravel the
inhibitory mechanisms of curcumin for lung cancer metastasis via
constructing a miRNA-transcription factor (TF)-target gene network. We
suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a
crucial mechanism in inhibition of lung cancer metastasis by curcumin.
The power of turmeric
inews880.com, March 2017
The active ingredient that we’re also concerned
about – or really interested in – is actually curcumin. It’s the main active
ingredient which holds the most inflammatory and anti-oxidant potential. The
beautiful thing about turmeric is that in all the recent studies and
journalism and medical information that we have, it’s really effective
against inflammatory conditions, like arthritis.
This centuries-old spice is the superfood of
2017
USA Today, March 2017
Turmeric fights inflammation, helps balance
blood sugar and cholesterol levels. The University of Maryland Medical
Center said it has been used for centuries to battle medical conditions and
research suggests it may help treat cancer and colitis.
Turmeric trumps meds
Mirror, March 2017
Turmeric contains curcumin, a power antioxidant
which has antiinflammatory properties. It is loaded with dietary fiber,
niacin and the vitamins C, E and K, as well as potassium, calcium, copper,
iron, magnesium and zinc. It acts as an immuno-booster, and helps in
developing resistance towards many bacterial, viral and fungal infections.
It also works like a muscle-relaxant by neutralising the extra gases and
toxins produced in the body. Being rich in fibre and an antiinflammatory
agent, curcumin also helps in weight reduction by reducing hunger pangs and
raising the metabolic rate.
Curcumin decreases malignant
characteristics
BioMedCentral.com February 2017
These findings indicate that curcumin may be a
safe future chemotherapeutic agent.
Environmental
Nutrition
Orlando Sentinel, February 2017
"Curcumin is the compound in turmeric that gives
it its bright yellow hue," says Rachael Hartley, R.D., L.D., C.D.E. It has
been shown to block enzymes in the inflammatory pathways, potentially
fighting inflammation at the molecular level, and it's being actively
studied for relief of swelling and pain in both osteoarthritis and
rheumatoid arthritis. Curcumin is also a powerful antioxidant, and lab and
animal studies have reported that curcumin inhibits cancer at multiple
stages of development, although we don't yet know how that might work in the
body. The anti-inflammatory and anti-oxidant effects could help reduce heart
disease risk, and this potent turmeric component also may help keep the
lining of veins and arteries healthy and reduce cholesterol levels.
Curcumin Is Associated with Downregulation of Cell Division
Cycle 20 in Pancreatic Cancer
Nutrients, February 2017
Curcumin could be useful for the treatment of
pancreatic cancer patients.
Turmeric and Curcumin
Food.ndtv.com February 2017
Curcumin belongs to a family of chemicals
that are known as curcuminoid and which have a bright yellow colour. It is
this compounds that lends the distinctive colour to the spice. Curcumin was
first identified as a compound back in 1815. Since then, there have been
several studies conducted to learn more about its abilities. It is believed
that curcumin works on multiple functions and processes at the same time
which is why it has been touted to cure everything from pain and
inflammation to fighting tumours and promoting brain health.
Cancer prevention
inUth.com February 2017
Curcumin with chemotherapy can treat bowel
cancer cells. The results were based on a laboratory test that showed that
the combined treatment killed more cancer cells than the chemotherapy alone.
How Turmeric Upgrades Your Organ
Systems & Treats Cancer, Inflammatory Disease
Collective-Evolution.com February 2017
Researchers have found that curcumin has a
positive effect on multiple systems in the body. For one, curcumin has been
found to modulate around 700 of our genes. Furthermore, it modulates over
160 physiological pathways. Curcumin also regulates our cell membranes,
allowing for more efficient transport of molecules in and out of the cell.
But one of the most amazing aspects of curcumin is its positive effect on
signalling molecules, which, if gone awry, can lead to chronic inflammatory
responses, autoimmune responses, issues with DNA and RNA regulation, and
more. In short, curcumin is a vastly important ingredient in the prevention
of almost all types of diseases.
Inhibitory Effect of Astragaloside
and Curcumin on Tumor Growth
Anticancer Research, February 2017
The combination of AS-IV and curcumin
demonstrated significant synergistic effects on microvessel count as well as
on expression of angiogenic and thrombosis-related factors and microRNAs.
Conclusion: The present study indicates future clinical potential of
combination therapy with AS-IV and curcumin.
Over 7,000 studies confirm
turmeric’s health-protective effects
Natural News, February 2017
A 2015 review published by the journal Molecules
states that curcumin — a key component of turmeric — can inhibit the
initiation, progression and metastasis of a number of different kinds of
tumors. The review authors also note that curcumin halts disease progression
by inducing apoptosis, or cell death. The team notes that at the time their
review was completed, some 6,850 studies of turmeric had been published,
noting that many of these were indicative of the spice’s potential health
benefits. In their conclusion, the authors write, “A plethora of in vitro
and in vivo research together with clinical trials conducted over the past
few decades substantiate the potential of curcumin as an anti-cancer agent.”
Active compounds in turmeric, onion
help fight colon cancer
Business Line, February 2017
Global research studies in the past decade have
also thrown up positive results on the impact of curcumin in preventing
colon and breast cancers. In a clinical trial, researchers in the US have
shown that people who eat large amounts of curries with ingredients like
turmeric and an antioxidant found in Onions called quercetin have beneficial
effects. There is a growing body of scientific literature from across the
world, including studies from the Hyderabad-based National Institute of
Nutrition, which highlight properties such as anti-inflammation, antioxidant
and anti-tumour attributed to curcumin.
Turmeric compound may treat colon cancer
Kashmir Monitor, January 2017
The researchers found that combination of two
plant compounds that have medicinal properties - curcumin and silymarin -
holds promise in treating colon cancer. Curcumin is the active ingredient in
the spice turmeric. The combination of phytochemicals inhibited colon cancer
cells from multiplying and spreading. In addition, when the colon cancer
cells were pre-exposed to curcumin and then treated with silymarin, the
cells underwent a high amount of cell death.
Health Benefits of Curcumin
foods4betterhealth.com January
2017 Turmeric
spice contains the healing compound, Curcumin, and studies have proved that
it is more advantageous than many prescription drugs. Curcumin has a good
ability to control inflammation. Oncogene published the results of a study
stating that among all the anti-inflammatory medications in the world,
aspirin and ibuprofen are the least effective, while curcumin is the most
effective. Inflammation causes diseases like cancer, ulcerative colitis,
arthritis, high cholesterol, and chronic pain. With arthritis drugs
(diclofenac sodium), people may develop a leaky gut and heart disease,
whereas with curcumin, treatment is safe and doesn’t have any adverse
side-effects. The countless benefits of curcumin helps to treat people
suffering from different types of arthritis.
Spice health benefits
The Gazette, January 2017
The active ingredient in turmeric is a powerful
antioxidant called curcumin. The American Cancer Society notes that a number
of studies have found curcumin kills cancer cells in vitro and reduces the
size of tumors in animals.
Curcumin improves glucose tolerance
Mol Nutr Food Res.,
January 2017 These findings demonstrate the biological function of curcumin as a GLP-1
secretagogue and the possible molecular target that mediates GLP-1
secretion. Increases in the secretion of endogenous GLP-1 induced by
curcumin may allow the dosages of other diabetic medicines to be reduced and
aid in the prevention of diabetes.
Health Benefits of Turmeric
Factskeeper.com January 2017
One recent study actually found that curcumin
from turmeric was more beneficial than some medications in reducing
oxidative stress in the body, inflammation in the body, and treating high
cholesterol.
Turmeric,
the spice of life
CBS News, January 2017
The very thing that makes turmeric so colorful
-- a compound called curcumin -- is what some researchers say also makes it
a powerful weapon against disease. Biophysicist Ajay Goel has been studying
its medicinal qualities at Baylor University Medical Center in Dallas.
“We’re doing clinical trials on Alzheimer’s disease, Parkinson’s disease,
arthritis, diabetes,” said Goel. “And it seems to have an effect on all
these different conditions?” Cowan asked. “Absolutely. It is such a
wonderful compound that has been shown to work in every single instance
people have tried.” Goel says thousands of studies have shown that, in a
concentrated-enough dose, the curcumin in turmeric has not only proven to be
an effective antioxidant and anti-inflammatory, but also shows promise in
preventing and even treating something as serious as cancer.
Study finds spices can help fight
cancer
ABC News, January 2017 There's now a volume
of scientific evidence showing that curcumin is a safe, and powerful
anti-inflammatory. "What we were missing at that time, we didn't have the
science behind it, we just knew that somebody took this and felt better,"
said Dr. Goel. After seeing an integrative medicine physician, she started
on curcumin capsules daily to reduce inflammation. "So I tried it and it
worked. There was nothing else I changed. No other variables whatsoever,"
Jones said. "It's a passion for me and I feel privileged in a sense that I
can see the science and I can see the anecdotal evidence, and I can see the
limitations. I can see the positive things," said Dr. Goel. Like possible
cancer prevention someday on a plate. A previous study by Professor Goel
found that taking curcumin while undergoing chemotherapy increased the
effectiveness of the treatment. If you are shopping for supplements and want
the full benefit of curcumin, buy curcumin capsules, not turmeric. Remember
turmeric is the spice, curcumin is the medicine.
The medicinal properties of turmeric
Seattle
Times, January 2017
The National Library of Medicine (PubMed.gov) contains thousands of research
articles on turmeric or its active ingredient curcumin. That’s because there
is intense interest in the medicinal properties of this Indian spice.
Curcumin is being studied for its activity against psoriasis, diabetes,
Alzheimer’s disease and a range of cancers. All of this research is being
conducted in animal models, but the anti-inflammatory activity of curcumin
has been shown to help nasal congestion in humans (Annals of Allergy, Asthma
and Immunology online, Oct. 24, 2016). It also has been shown to help knee
pain due to arthritis when taken as a supplement (Nutrition Journal, Jan. 5,
2016).
Curcumin sensitizes human gastric
cancer cells
Chemical Biology Research Center, Wenzhou Medical
University, December 2016 The combination of 5-FU and curcumin could be
further developed as a potential therapy for human GC.
4 Ways Food Can Fight Muscle
Soreness
IronMan.com December 2016 For centuries,
curcumin has been prized in Asia for its purported benefits in health.
Curcumin, like quercetin, has been investigated in a variety of exercise
recovery models, including its impact on exercise-induced muscle soreness. A
recent study compared the effects of 2.5 g curcumin or placebo taken twice
daily for two days before and three days following a bout of heavy eccentric
exercise. When subjects consumed curcumin, muscle soreness was lower at 24
and 48 hours after exercise with some evidence for enhanced recovery of
muscle performance compared to placebo. In another study, subjects given 200
mg curcumin two times per day for 48 hours prior to and following a single
bout of downhill running experienced less muscle soreness than subjects
given placebo. Collectively, these findings suggest curcumin supplementation
may dampen exercise-induced muscle soreness and support recovery.
Spice may help fight cancer
Vindi.com December 2016 The evidence is
especially strong for curcumin, an active component of turmeric. It has the
ability to interrupt metabolic pathways that cancer cells use to survive and
spread (Anticancer Research, November 2016). Curcumin also may have activity
against lung, breast, stomach, colorectal and uterine cancer.
The 7 Foods That Relieve Joint Pain
Tthe Weekly Challenger, December 2016 Curcumin, a compound found in turmeric, has been shown to help suppress
cancer, reduce blood pressure, and have a positive impact on inflammation,
just to name a few. One University of Arizona study found that the curcumin
can help protect against joint deterioration and inflammation caused by
rheumatoid arthritis. Another study researched how well ibuprofen eased pain
over curcumin, and found that the benefits were about the same for both.
Study Finds the Spice Curcumin
Fights Depression
MadeInAmerica.com December 2016 A new study,
published online ahead of print in the Journal of Affective Disorders, finds
that the spice curcumin, a derivative of turmeric, may be an effective
treatment for depression. The study was a randomized, placebo-controlled
trial (the gold standard methodology for medication studies). The
researchers found that curcumin was better than a placebo treatment, and
those with atypical depression were far more likely to improve.
Compound
in turmeric may treat colon cancer: study
The Hindu, December 2016 Researchers studied a
line of colon cancer cells in a laboratory model. They found treating the
cells initially with curcumin, then with silymarin was more effective in
fighting cancer than treating the cells with either phytochemical alone.
“The combination of phytochemicals inhibited colon cancer cells from
multiplying and spreading. In addition, when the colon cancer cells were
pre-exposed to curcumin and then treated with silymarin, the cells underwent
a high amount of cell death,” said Uthayashanker Ezekiel from Saint Louis
University.
The
health benefits of tumeric
HanfordSentinel.com December 2016 Health
benefits of curcurmin: Reduces whole body inflammation Reduces joint pain
from arthritis Helps maintain healthy cholesterol levels Helps maintain body
weight and may delay or reduce the onset of type 2 diabetes Reduces
heartburn and stomach upsets Improves memory and brain function Good for
skin problems Cancer prevention
Dietary inflammatory index and
telomere length
American Society for Nutrition, December 2016 Lifestyle factors could affect the health and longevity of an individual by
modifying telomere length (TL)12 (1), a molecular proxy for estimating
cellular aging (2). In this context, several studies in humans have looked
into the effects of dietary components on TL (1, 3–6). The 2 main mechanisms
implicated in the association between diet and leukocyte TL are oxidative
stress and inflammation (7). Therefore, it is expected that an antioxidant
or an anti-inflammatory diet could lessen the rate of telomere shortening,
which may delay aging. Indeed, a higher intake of specific antioxidants and
anti-inflammatory dietary components such as vitamin C or E, polyphenols,
curcumin, or omega-3 (n–3) fatty acids have been associated with longer
telomeres.
Can You Spice Up Your
Antidepressant? The evidence for curcumin in depression
Psychology Today, December 2016 Curcumin is
more interesting than many other alternative-medicine highly-touted
phytochemical compounds as an anti-inflammatory because there’s already
about a decade of human data for adjunctive and/or remission stability
improvement from curcumin in
autoimmune diseases such as
ulcerative colitis. These studies show some
benefit and very few side effects at fairly high doses, double or quadruple
those used in the depression studies.
The 7 Incredible Health Benefits of
Turmeric
ClapWay.com December 2016 With curcumin’s
anti-inflammatory properties, turmeric helps stimulate the body’s natural
defense mechanisms, which helps the body to heal and preserve itself
naturally. The reputation of turmeric for reducing inflammation actually
owes to its active ingredient, curcumin. You also may want to start adding
ginger to your pain or inflammation tonics for an even more potent effect.
Turmeric can assist in the lowering of cholesterol and also prevent the
blockage of arteries that can cause heart attacks and strokes. Curcumin can
lower cholesterol levels and also inhibit the oxidation of LDL.
6 Reasons to Always Have Turmeric
VozdeguanaCaste.com December 2016 Curcumin has
substances that regenerate and protect the liver. A study by the Medical
Association of Thailand links this substance to an effective fight against
cancer and an improvement of the organ’s fibrous tissue, as well as to the
regeneration of affected hepatic cells. Curcumin also is linked to
improvements in gallbladder health. Curcumin is important nourishment
against cancer, as it blocks the development of cells and promotes apoptosis
(cell self-destruction), differentiating between carcinogenic cells and
normal ones. At the same time, it can halt metastasis (spreading of cancer
from one organ to another), according to the findings of a 2011 study by the
University of Texas Anderson Cancer Center. According to the Arthritis
Foundation, curcumin eases pain, swelling and stiffness associated with
rheumatoid arthritis and osteoarthritis. Curcumin’s antioxidant and
anti-inflammatory properties can be used as a complementary tool in the
treatment of depression, according to a 2014 study published in the Journal
of Affective Disorders. According to the 2014 edition of the magazine
BioMed Research International, several studies have shown that curcumin acts
against a range of bacteria and microbes. Consuming it has antiviral,
antimicrobial and antifungal effects.
Boost brain performance, reduce
cognitive decline
BonnerCountyDailyBee.com December 2016 Curcumin, extracted from the spice turmeric, helps remove toxic waste,
disrupt formation of plaques, and has anti-inflammatory properties. It
tweaks a major control point that regulates many other activities in brain
cells by encouraging them to operate in a balanced matter.
The
best supplements to take for over-60s
Startsat60.com December 2016 Due to its
ability to block inflammation, curcumin could help stop disease-causing
inflammation found in cancer, diabetes, cardiovascular disease, cystic
fibrosis, and depression. Turmeric can also treat rheumatoid arthritis. Dr
Greg Cole, associate director of UCLA’s Mary S Easton, spent years studying
curcumin as a treatment for brain diseases specifically Alzheimer’s disease
and dementia. In his long time studying curcumin as a cure, he has observed
that it reduces the build-up of this disease in the brain.
Efficacy of curcumin, and a saffron/curcumin
combination for the treatment of major depression: A randomised,
double-blind, placebo-controlled study
Journal of Affective Disorders, November 2016
Active drug treatments comprising differing
doses of curcumin and combined curcumin/saffron were effective in reducing
depressive and anxiolytic symptoms in people with major depressive disorder.
Study Says This SPICE Might Be As Effective For
Depression As Prozac
inquisitr.com November 2016
This study provides first clinical evidence that
curcumin may be used as an effective and safe modality for treatment in
patients with MDD without concurrent suicidal ideation or other psychotic
disorders.
Healthy Living: Curcumin To Fight Cancer?
9and10news.com November 2016
A previous study found taking curcumin while
undergoing chemotherapy increased the effectiveness of the treatment. If you
are shopping for supplements and want the full benefit of curcumin, buy
curcumin capsules, not turmeric. Remember turmeric is the spice, curcumin is
the medicine.
The mood and cognitive effects of curcumin from
turmeric
The Fiji
Times, November 2016
Curcumin is the
component of turmeric (Curcuma longa) that gives the spice — and many
curries — its bright yellow colour. It is one of more than 5000 flavonoids,
a group of plant-based compounds thought to contribute to the health
benefits of fruit and vegetables. While any meaningful clinical effects are
far from proven, at least the trials have a scientific foundation. Curcumin
has significant anti-inflammatory properties that are said to rival those
found in ibuprofen, the active ingredient in Nurofen. Unlike
over-the-counter drugs though, turmeric has no known toxic effects on the
body. Curcumin's powerful antioxidant advantages have been shown to protect
healthy cells in research, particularly those found in the colon, from
cancer-causing agents. It aids the body in destroying mutated cancer cells
before they have a chance to spread to other areas.
5 Top Natural Cancer-Fighting Supplements
NewsMax Health, November 2016
Curcumin. Turmeric is a spice used to flavor
traditional Indian dishes, and its active component is curcumin, a potent
anti-inflammatory that gives turmeric its bright yellow color. Studies show
it can fight even the deadliest cancer — pancreatic, which has a 5-year
survival rate of only 7 percent. A Phase II clinical trial at MD Anderson
Center gave 25 pancreatic cancer patients 8 grams of turmeric a day for two
months. Tumor growth stopped in two patients, one for eight months and
another for two-and-a-half years. Another patient's tumor temporarily
regressed by 73 percent. The only two drugs approved by the FDA are
effective in no more than 10 percent of patients, and turmeric's
effectiveness was similar with no side effects. In another study, turmeric
reduced tumor growth in mice with pancreatic cancer by 43 percent. When
combined with fish oil, which helps the body absorb turmeric, tumor growth
was reduced by 70 percent. A study at the University of Missouri found that
curcumin decreased the incidence of progestin-accelerated breast tumors in
animals. It also delayed onset of the disease and reduced the incidence of
multiple tumors.
Let turmeric color your life
DELANO News, November 2016
Curcumin is also protective of the liver, it
lowers blood fat levels and it reduces weight gain. In some cases it is
effective against hay fever and it can help treat inflammatory skin
conditions, too. Of course, as it is a bitter, it also stimulates digestion
and keeps the digestive muscular system working smoothly.
The Healing Properties Of The Eastern Diet
Explained
Luxury
London, November 2016
Curcumin
in turmeric works to fight free radicals and aid with blood flow and
circulation.
Turmeric and Exercise: a Magic Combination for
Heart Health
Care2.com
November 2016
The
magnitude of the improvement achieved by curcumin treatment was comparable
to that obtained with exercise. Therefore, regular ingestion of curcumin
could be a preventive measure against cardiovascular disease. Furthermore,
results suggest that curcumin may be a potential alternative treatment for
patients who are unable to exercise.
The 7 Foods That Relieve Joint Pain
The Huffington Post,November 2016
The health benefits of turmeric—the yellow spice
that flavors curries—are vast. Curcumin, a compound found in turmeric, has
been shown to help suppress cancer, reduce blood pressure, and have a
positive impact on inflammation, just to name a few. One University of
Arizona study found that the curcumin can help protect against joint
deterioration and inflammation caused by rheumatoid arthritis. Another study
researched how well ibuprofen eased pain over curcumin, and found that the
benefits were about the same for both.
Curcumin modulates the effect of histone
modification
International Journal of Chronic Obstructive Pulmonary Disease, November
2016
Curcumin may
suppress chemokines and restore corticosteroid resistance in COPD through
modulating HDAC2 expression and its effect on histone modification.
9 amazing health benefits of turmeric curcumin
BT.com October 2016
1. Kill cancer: The curcumin in turmeric has been
found capable of killing cancer cells and able to slow the growth of
tumours. 2. Soothe arthritis: “In a 2013 study, turmeric was shown to
significantly reduce the severity of chronic joint inflammation in those
with rheumatoid arthritis,” notes Abby Sauer, registered dietitian at
Abbott. “In addition, turmeric has been considered as a promising treatment
to reduce osteoarthritis pain due to its anti-inflammatory benefits.” 3.
Fight diabetes: “When taken daily, turmeric’s most prominent component,
curcumin, has been shown to delay the development of type 2 diabetes in
patients who were at high risk of developing the disease,” says Sauer. 4.
Deal with depression: Along with certified medical and psychological help,
“turmeric has been shown to reduce depressive symptoms, and boost patient’s
treatment success,” explains Sauer. 5. Avoid heart attacks: Those at risk of
heart attack tent to suffer plaque build-up, known as atherosclerosis, in
their arteries. “Turmeric has been found in animal studies to prevent blood
clots from building up along artery walls, which could give patients with
atherosclerosis a significant chance to reduce their risk of a heart
attack,” says Sauer. 6. Tackle gut conditions: In patients with ulcerative
colitis in remission, says Sauer, “turmeric was found to noticeably assist
conventional medical treatment to keep patients in remission”. 7. Limit
reflux: “Turmeric’s antioxidant and anti-inflammatory properties have been
shown to reduce inflammation in the oesophagus,” which can cut the effects
of reflux after eating, says Sauer. 8. Lower your cholesterol: That good old
curcumin in turmeric has also been found to help balance out cholesterol
levels. 9. Pain relief: Traditionally turmeric has been used as a natural
painkiller, and have even been shown to mimic the effects of steroids.
Turmeric Beats Depression, Active Ingredient
Curcumin Works As Well As Prozac
inquisitr.com October
2016 Multiple studies have now shown that the active
ingredient in turmeric, curcumin, is an effective treatment against clinical
depression and is as effective in treating serious depression as Prozac —
perhaps even more so. Turmeric, a member of the ginger family, is probably
best known for its culinary uses. It is frequently used in Indian dishes and
as a natural food coloring because of its distinctive yellow color. Turmeric
has been also used for thousands of years in treating a multitude of health
conditions. Green Med Info, which compiles research studies on natural
health products, lists over 2,000 research studies that proved benefits of
turmeric ranging from treating arthritis to helping with weight loss to
relieving symptoms of Irritable Bowel Syndrome, just to name a few. Hundreds
of other health benefits of turmeric have also been reported.
If You Are Prone To Allergy, Make Sure You
Regularly Eat These 10 Superfoods
Boldsky.com October 2016
The curcumin content in turmeric makes it a strong
anti-allergic agent. Curcumin is an antioxidant and anti-inflammatory
compound that equips our immune system to fight allergies.
Popular ingredient in Indian food may help fight
cancer
WNDU.com
October 2016 Taking curcumin while undergoing chemotherapy
increased the effectiveness of the treatment. If you're shopping for
supplements and want the full benefit of curcumin, buy curcumin capsules,
not turmeric.
Spices with benefits
Food in Canada, October 2016
The active ingredient of turmeric, called
curcumin, is a type of polyphenol. Among other things, curcumin has been
shown to help prevent depression in mice, and scientists are studying its
impact on treating Alzheimer’s disease. Studies on rats from a few years ago
showed that turmeric could help prevent and maybe even reverse liver damage,
and there are ongoing studies looking into its impact on treating or
preventing cancer, particularly colon cancer. It’s also been studied as an
anti-inflammatory, a treatment for arthritis, a preventative measure for
people at risk of developing diabetes, and more.
Curcumin Can Protect Your Brain from Dementia
and Alzheimer’s Disease
MensFitness.com October 2016
Curcumin—a bright orangeish chemical compound
that’s found in turmeric and is integral to most curries and many other
Asian foods (not to mention good old American mustard!) has already been
shown to be a powerful anti-inflammatory. Now evidence is growing that it
also stymies the destruction of brain neurons—meaning it may combat dementia
and even Alzheimer’s disease. Researchers in a year long study at
Australia’s Edith Cowan University gave cognition tests to 96 middle-aged
and elderly subjects, then sent half of them home with concentrated curcumin
pills, and the other half with a placebo. When all were retested just six
months later, those who’d been taking the placebo showed a decline in verbal
and memory skills—but the ones taking curcumin showed no such decline.
How Turmeric Wards Off Infectious Diseases
AllAfrica.com October 2016
Several medical properties have been attributed to
Curcumin (Curcuma longa). The rhizome is known to possess therapeutic
activities and has been used by medical practitioners as an anti-diabetic,
hypo-lipidemic, anti-inflammatory, anti-diarrhoeal, hepato-protective,
anti-asthmatic and anti-cancerous drug. Curcuma longa is widely used in
cosmetology.
Curcumin fights ovarian cancer
ScienceDirect.com October 2016
Curcumin increases cytosolic Ca2+ concentration
through inhibition of SERCA activity, causing apoptosis in ovarian cancer
cells.
The spice for joint inflammation:
anti-inflammatory role of curcumin in treating osteoarthritis
US National Library of Medicine, October 2016
Osteoarthritis is a significant medical condition
for the aging population worldwide. Curcumin, a NF-κB suppressor,
demonstrates potential as a treatment agent for osteoarthritis, a disease
with an underlying inflammatory cause. Its efficacy in reducing pain,
physical function, and quality of life among osteoarthritic patients has
been demonstrated in many clinical trials. The effects of curcumin on
osteoarthritis can be attributed to its ability to prevent apoptosis of
chondrocytes due to inflammation predominantly, and oxidative stress to a
lesser extent. Randomized controlled trials involving larger sample size and
longer treatment, proper selection of patients, and improved formulation
could better justify the use of curcumin as an alternative treatment for
osteoarthritis.
Curcumin for Anti-Cancer and Other Profound
Benefits
Natural
Products Insider, October 2016
Curcumin is a naturally occurring chemical
compound that is found in the spice turmeric. Several studies suggest
curcumin might ease symptoms of osteoarthritis and rheumatoid arthritis,
including pain and inflammation. Moreover, these potent anti-inflammatory
benefits seem to be quite protective against some forms of cancer
progression. However, curcumin has additional anti-cancer effects that are
independent of its anti-inflammatory effects and thus is a heavily
researched molecule for both cancer prevention and treatment. Studies have
shown curcumin helps prevent several forms of cancer including breast, lung,
stomach, liver and colon. It stops development of cancer by interfering with
the cellular signaling aspects of this chronic disease. Interestingly, my
research unveiled curcumin has "smart kill" properties that actually work to
inhibit the growth of tumors and the spread of cancer in fundamental ways at
the cellular level. It has the laboratory-proven capability to inhibit a
particular cancer-promoting enzyme (COX-2), impede blood supply to cancer
cells, induce tumor-suppressing genes, stop metastasis, kill lymphoma cells
and prevent the regrowth of cancer stem cells. The ability to target cancer
stem cells is one of curcumin’s most powerful anti-cancer properties. In
fact, according to GreenMedInfo.com, a recent study describes the wide range
of molecular mechanisms presently identified by which curcumin attacks
cancer stem cells (CSCs), which are the minority subpopulation of
self-renewing cells, within a tumor colony. These stem cells alone are
capable of producing all the other cells within a tumor, making them the
most lethal, tumoriogenic of all cells within most, if not all, cancers.
Because CSCs are resistant to chemotherapy, radiation, and may even be
provoked toward increased invasiveness through surgery, they are widely
believed to be responsible for tumor recurrence and the failure of
conventional cancer treatments. These are compelling findings, indeed.
Furthermore, some of the most fascinating curcumin research also dovetails
with what I experience so much of: muscle soreness. A new, double-blind,
randomized-controlled study published in the European Journal of Applied
Physiology in March 2015 indicated curcumin can help reduce pain associated
with delayed onset muscle soreness (DOMS) and aid muscle recovery in
physically active people.
This Is Why Turmeric Should Be In Your Kitchen
Cupboard
Grazia Daily,
October 2016 A new study published in the journal Phytotherapy
Research has confirmed that the chemical curcumin found in turmeric is safe
and effective in treating depression. Initial experiments indicated that
turmeric extract and curcumin reduced the development of animal tumors.
Curcumin
prevents muscle damage
Journal of Inflammation
Research, September 2016
Exercise (Ex) increases reactive oxygen species
and impairs antioxidant defense systems. Recent data suggest that curcumin
(CW) possesses peroxisome proliferator-activated receptor gamma activity and
anti-inflammatory properties. Therefore, this study was designed to
investigate the effects of CW supplementation on Ex performance, endurance,
and changes in serum and muscle proteins in rats after exhaustive Ex.
Curcumin and silymarin form promising pair for
colon cancer treatment
Yahoo.com, September 2016
The Journal of Cancer has published a study
revealing the therapeutic effects of two antioxidant compounds when combined
to fight colon cancer. Curcumin is the active ingredient in turmeric,
already known for its anti-inflammatory properties, whereas silymarin, a
component of milk thistle, has been used to treat liver disease. In
laboratory tests, researchers from Saint-Louis University in the USA found
that colon cancer cells stopped multiplying and spreading, and that cell
death increased when exposed to the two natural compounds.
Curcumin helps lung cancer
Foodconsumer.org September 2016
The scientists found curcumin supplementation
down-regulates the expression of inflammation biomarkers and promotes
apoptosis in cancer cells.
Colon Cancer Treatment: Turmeric Compound
‘Curcumin’ Highly Effective, New Study Finds
Science World Report, August 2016
A new study has found that curcumin, a compound
present in spice turmeric, has the potential to treat and prevent colon
cancer.
To add some spice
The Daily Star, August 2016
Curcumin, the active component of turmeric, is an
object of research owing to its properties that have the potential to turn
off certain genes that cause scarring and enlargement of the heart. Regular
intake may help reduce low-density lipoprotein (LDL) or bad cholesterol and
high blood pressure, increase blood circulation and prevent blood clotting,
helping to prevent heart attack. Curcumin also kills cancer cells and
reduces the size of tumours. Turmeric aids in treating arthritis, heartburn,
stomach pain, diarrhoea, intestinal gas, stomach bloating, and loss of
appetite. Turmeric is also used as a topical treatment for issues like skin
inflammation, infected wounds, and ringworm.
Naturally Detox
PopSugar, August 2016
This super spice contains high levels of a
compound called curcumin, which has powerful antioxidant and
anti-inflammatory actions. According to a study in the Journal of the
Medical Association of Thailand, curcumin enhances liver health and offers
protection from liver cancer and disease. This powerful antioxidant can also
repair and regenerate damaged liver cells. It's basically magic in a spice.
5 reasons why you must include ‘haldi’ in your
diet
Tribune, August
2016 Curcumin
supplements showed that root can potentially prevent heart attacks. This
particular study was conducted on a group of patients that had previously
undergone bypass procedures. It was proved that 30% of the individuals from
the placebo group experienced heart attacks during their hospital stay,
compared to only 12% of the ones from the supplement group. Keep in mind
that this does not mean you start swallowing large spoonfuls of the spice to
avail all these health benefits. The powdered spice in your kitchen contains
less than 10% of Curcumin. Consult your physician to learn about FDA
recommended supplements for best results.
Suffering from colon cancer? Turmeric may be the
cure
Science Daily,
August 2016 A
preliminary cell study finds combining curcumin, the active ingredient in
spicy curry dishes, and silymarin, a component of milk thistle, inhibited
the spread of colon cancer cells and increased cancer cell death
Herbal Cure: Turmeric
Can Help Fight Colon Cancer
Health Newsline, August 2016
For the lab test, researchers used
three different human colon cancer cell lines and treated them
with varying doses of curcumin, silymarin, and a combo of
curcumin and silymarin. Cell proliferation (increase in the
number of cells) and apoptosis (a process of programmed cell
death) were assessed after treating the cells with the
compounds. The research team observed a significant difference
between single compound-treated cells and cells treated with a
combo of both compounds. They found cells treated with either
phytochemical alone had low levels of apoptosis, while treating
the cells first with curcumin and then with silymarin resulted
in an increased cell death, thus was more effective in fighting
cancer. “The combination of phytochemicals inhibited colon
cancer cells from multiplying and spreading. In addition, when
the colon cancer cells were pre-exposed to curcumin and then
treated with silymarin, the cells underwent a high amount of
cell death,” said study author Dr. Uthayashanker Ezekiel, from
Saint Louis University.
A recent research has revealed that the
turmeric has a compound that treat colon cancer.
News World India, August 2016
The study found that combination of two plant
compounds- curcumin and silymarin – holds promise in treating colon cancer as
both have medicinal properties. Curcumin is the active ingredient in the spice
turmeric while silymarin is a component of milk thistle, which has been used to
treat liver disease. Treating the cells initially with curcumin, then with
silymarin was more effective in fighting cancer than treating the cells with
either phytochemical alone.
Up-and-Coming Kitchen Spices
Whole Foods Magazine, August 2016
When using turmeric as a culinary spice, choose
dried turmeric rather than curry powder for the highest concentration of
curcumin (12). Curcumin, the pigment that gives turmeric its yellow-orange
color, is well known for its powerful antioxidant and anti-inflammatory
properties (12). Studies suggest curcumin may lower the levels of enzymes that
cause inflammation and prevent platelets from clumping. In one study, turmeric
worked as well as ibuprofen for reducing osteoarthritis pain.
Where to turn for relief from joint
pain, arthritis
The Dickenson Press, August 2016
Favorite natural
supplements that provide unique synergistic benefits in the management of
osteoarthritis, rheumatoid arthritis, and even joint support for the hardcore
and recreational athletes. The first ingredient is curcumin. I have called
curcumin my desert island nutrient due to its multiple benefits of
detoxification, digestive, cellular, mood, cognitive, antioxidant and
musculoskeletal support. Besides the effectiveness of curcumin, what I really
love is that it counteracts negative side effects of both NSAID's and
acetaminophen. Curcumin has been used to actually treat ulcers, as NSAID's are
known to cause ulcers. Where acetaminophen can lead to liver damage, curcumin
has shown to be supportive of both liver and kidney function. As far as
effectiveness goes, curcumin has shown to be more effective than prescription
diclofenac for reducing pain and enhancing mobility. In another study, a
combination of curcumin, and my next favorite ingredient, boswellia, performed
better than the prescription anti-inflammatory celecoxib (Celebrex).
Psychopharmacology and
Neuropsychopharmacology Research
News-medical.net August 2016
The study was
funded by Verdure Sciences and found that in individuals who regularly consumed
curcumin, memory and attention capabilities improved. Curcumin also seemed to
inspire calmness, contentedness, and improved energy levels in observed subjects.
Can Turmeric Cure Our National
Inflammation?
New York Magazine, August 2016
Curcumin, the chemical turmeric produces, is a
powerful anti-inflammatory. And inflammation is a hot topic (sorry again) in
wellness circles. “There’s this idea where if you have free-floating
inflammation you are much more vulnerable to all sorts of things from heart
disease to skin aging,” says Jean Godfrey June, the beauty director of Goop.
Until recently, she points out, “The culture in skin care, and in medicine I
think, has been to attack and fight. But now people are realizing that harsh
treatment makes inflammation worse, and that soothing your system is more
important.” This, if anything, explains the popularity of turmeric in America in
2016.
Examining Turmeric's Role in Fighting
Cancer
Curetoday.com August 2016
Curcumin has demonstrated incredible anticancer
benefits. In countries where people eat turmeric daily, research has shown that
there are lower rates of certain types of cancer. Ingesting levels of about 100
to 200 mg a day over long periods of time seem to work best in most cases. In an
article by Cancer Research UK it was said that studies on cancer cells have
shown “…that curcumin does have anticancer effects. It seems to be able to kill
cancer cells and prevent more from growing. It has the best effects on breast
cancer, bowel cancer, stomach cancer and skin cancer cells.” Curcumin has been
extensively researched for many years and although promising results have been
obtained from laboratory trials, it is still not seen as a widely prescribed
cancer therapy.
The many uses for turmeric
The Spectrum, August 2016
Turmeric is antioxidant, anticarcinogenic,
antimicrobial, antibiotic, antimutagenic, and anti-inflammatory. The chemical in
turmeric that reduces inflammation and has many other benefits is called
curcumin.
Bodily Tissues That Can Be Regenerated
Through Nutrition
Collective-Evolution.com August 2016
Curcumin
supplements can help treat crushed nerve injuries, and pave the way for the
regeneration of damaged tissues. “Curcumin is capable of promoting nerve
regeneration after nerve injuries, highlighting the therapeutic values of
curcumin as a neuroprotective drug for peripheral nerve repair applications.”
For the love of turmeric
Fosters.com August 2016
Curcumin, extract of turmeric, breaks down
amyloid-beta plaques which contribute to the effects of Alzheimer's disease.
India has a low incidence of the disease which could be attributed to their use
of turmeric.
Study says Turmeric key to treating
various types of cancer
The Standard, August 2016
Turmeric contains curcuminoids, which are the main
component found to be effective in cancer treatment. “Curcumin, the principal
curcuminoid of turmeric, has been intensely studied as a cancer protective
agent. Its potential has been tapped in head and neck cancers, breast, lung,
gastro-intestinal cancer, ovarian cancer, melanoma, neurological cancers,
sarcoma, leukemias and lymphoma,” said the study. “Curcumin suppresses all three
stages of carcinogenesis: initiation, promotion and progression. It also has a
role in neutralizing substances and conditions which lead to cancer.” “By
inhibiting the enzyme Topoisomerases, which is required for multiplication of
cancer cells, it is able to arrest the growth of these cells,” said Sharma. With
time, cancers cells tend to become resistant to chemotherapy and radiotherapy,
Sharma observed. Curcumin, on the other hand, when consumed in therapeutic
doses, targets several cancer pathways and sensitizes the cancer cells to
chemotherapy drugs by increasing the pace of death of the cancer cells, she
said. “Studies in advanced breast cancer have also shown that curcumin increases
the effect of chemotherapy and prevents the spread of cancer cells to the lung,”
she said. “In lung carcinoma, when curcumin is added to the chemotherapeutic
drug, it increases the effectiveness of the drug by promoting cell death of
cancer cells. The efficacy of it has also been seen in the brain tumors where it
sensitises the tumor cells to the cancer drugs,” said Sharma. The study shows
curcumin enhanced the effect of radiotherapy by inhibiting tumor regrowth per
se, and also by suppressing new vessel formation. Being a powerful antioxidant
it scavenges all the harmful free radicals induced by radiation exposure of the
cells, thereby reducing the side effects of radiotherapy. According to
Delhi-based Nutritionist Anshul Jaibharat, “To be brief, turmeric can termed as
an Indian wonder spice. It’s anti-inflammatory and hence helps in people
suffering from arthritis. It works as an antiseptic and is warm in nature so
it’s good for people having cold and cough during changes in weather. The raw
form when grinded has the best nutritional value even more than the processed
and packaged one. The compound curcumin in turmeric has shown numerous benefits
to human body as per both Ayurveda and Modern science.” – from NDTV
How Curcumin Has Helped Me Control My Pain
ProHealth July 2016
Curcumin–an anti-inflammatory compound extracted
from the medicinal herb turmeric. A search on PubMed alone yields 130 studies on
the topic of curcumin and pain. Curcumin assists the body in mediating several
inflammatory processes. I stumbled upon the benefits of curcumin in 2010, as
facial muscle spasms, neck, and low back pain kept me in constant agony. At that
time, I was diagnosed with fibromyalgia. Determined to find some help, I dove
into the well-worn pages of one of my favorite books, Prescription for Natural
Cures, by James Balch, M.D. and Mark Stengler, N.D. In this book, the clinicians
refer to curcumin as an outstanding anti-inflammatory herb.
9 Reasons Turmeric Is The Top Culinary Medicine
LongevityLive.com July 2016
Whether we are healing from an injury or an
autoimmune disease, inflammation is a common health challenge. Nutritionists,
functional medicine GP’s and physiotherapists commonly use curcumin for it’s
anti-inflammatory qualities.
The Superfood Spice
Thrillist.com July 2016
Besides being used for thousands of years in Chinese
and Ayurvedic medicine, turmeric's many health benefits have also been backed up
by modern science.
This Spice Can Keep Bad Thoughts Away
Delish.com July 2016
Published in the journal Neuropsychopharmacology,
the study says that turmeric—which is often used in curries and mustard—can
impair your ability to recall fear-related memories. This is due to an abundance
of curcumin, a chemical responsible for turmeric's anti-inflammatory properties
and potential anti-depressant uses. So far the study has only tested rats but
the results imply that curcumin could be applied to help fight disorders like
PTSD.
Turmeric : Get To Know the 'Curcumin' Loaded Spice
That Can Block Off Bad Memories
ParentHerald.com July 2016
In a study lead by Professor Glenne Schafe, it was
noted that the rats who consumed curcumin, an element present in turmeric, are
more likely to forget bad memories. The rats who fed on curcumin are not fully
functional when it comes to encoding "fear memories." "We showed that rats
freely fed a diet enriched with curcumin [found in turmeric] have impaired
encoding of fear memories," lead of the study Professor Glenne Schafe said. "We
also showed that rats with a pre-existing fear memory can lose that memory when
it is recalled while they are eating a curcumin-enriched diet." The researchers
came to conclusion that rats who were fed curcumin were able to hide negative
memories for a long period of time. Repressing memories make it hard for them to
go through painful experiences as curcumin repels the negative experiences that
affects the rats. Curcumin, which is preset in turmeric is said to have a
positive soothing effect which acts as an anti-inflammatory, it is also known to
be chemopreventive, and is said to have anti-depressant properties.
Spice up
TheStar.com July 2016
Turmeric is a spice derived from the roots of
the Curcumin longa plant, which is native to Southeast Asia. The most active and
best-studied curcuminoid of all is curcumin, which is often extracted from
turmeric and sold as a supplement. Turmeric has anti-inflammatory functions that
are similar to omega-3 fatty acids, the key type of fat found in fatty fish,
like salmon. That could translate to potential benefits for heart and joint
health, and indeed, several studies suggest curcuminoids could help reduce
symptoms of osteoarthritis, the painful condition caused by the breakdown of the
cartilage cushion between joints, to an extent similar to the anti-inflammatory
ibuprofen, and with fewer digestive side-effects. Other studies suggest curcumin
could help manage digestive disorders. In one study, more than half of patients
with ulcerative colitis found themselves in remission after taking 3,000 mg of
curcumin per day for four weeks compared with none of the patients given a
placebo. There are also suggestions curcumin could help prevent the onset of
diabetes, control blood pressure, and even minimize muscle soreness after
exercise, though not all studies have produced positive results. A number of
studies on animals and human cells also suggest curcumin could have anti-cancer
effects, and at least one study demonstrated that taking two or four grams of
curcumin per day for a month was associated with slower development of
pre-cancerous changes in the colon of in smokers.
Turmeric Is Effective In Treating Various Types Of
Cancer: Study
NDTV.com July 2016
Curcumin, the principal curcuminoid of turmeric, has been intensely studied as a
cancer protective agent. Its potential has been tapped in head and neck cancers,
breast, lung, gastro-intestinal cancer, ovarian cancer, melanoma, neurological
cancers, sarcoma, leukemias and lymphoma," said the study. Tapaswini Sharma,
Senior Consultant (Surgical Oncology) at B.L. Kapoor Memorial Hospital, said:
"Curcumin suppresses all three stages of carcinogenesis: initiation, promotion
and progression. It also has a role in neutralising substances and conditions
which lead to cancer." "By inhibiting the enzyme Topoisomerases, which is
required for multiplication of cancer cells, it is able to arrest the growth of
these cells," said Sharma. With time, cancers cells tend to become resistant to
chemotherapy and radiotherapy, Sharma observed. Curcumin, on the other hand,
when consumed in therapeutic doses, targets several cancer pathways and
sensitizes the cancer cells to chemotherapy drugs by increasing the pace of
death of the cancer cells, she said. "Studies in advanced breast cancer have
also shown that curcumin increases the effect of chemotherapy and prevents the
spread of cancer cells to the lung," she said. "In lung carcinoma, when curcumin
is added to the chemotherapeutic drug, it increases the effectiveness of the
drug by promoting cell death of cancer cells. The efficacy of it has also been
seen in the brain tumours where it sensitises the tumour cells to the cancer
drugs," said Sharma. According to the study, curcumin enhanced the effect of
radiotherapy by inhibiting tumour regrowth per se, and also by suppressing new
vessel formation. Being a powerful anti-oxidant it scavenges all the harmful
free radicals induced by radiation exposure of the cells, thereby reducing the
side effects of radiotherapy.
Turmeric effective in treating various types of
cancer
Indian Express, July 2016
Turmeric has nearly 20 molecules with
antibiotic property, 14 molecules with cancer preventive potential, 12 with
anti-tumour effect, says the study conducted by BL Kapoor Memorial Hospital, New
Delhi. “At least 12 molecules in it have anti-cancer effect while 10 of them
have anti-oxidant features. Overall, turmeric is known for it’s antibiotic,
antiseptic, anti-cancer and anti-oxidant property. It is known to be a good
digestive substance,” said the study. According to the study, turmeric contains
curcuminoids which are the main component found to be effective in cancer
treatment.
What Are the Benefits of Turmeric and Curcumin?
Transcend.org June 2016
Research within the 50 years has shown much of the
supposed benefit of turmeric is due to curcumin, the active component. Curcumin,
a polyphenol, has displayed activity in antioxidant, anti-redness, anti-harmful
organism capacities. Because of this, polyphenols have generated inquiries into
their potential to provide support for ailments proven to be therapy resistant,
including chronic illnesses.
Curcumin and cognition: a randomised,
placebo-controlled, double-blind study
Br J Nutr.
June 2016 "a decline
in function of the placebo group at 6 months that was not observed in the
curcumin treatment group."
Hot Trends
in Healthy Eating for 2016
TNTMagazine.com July 2016
Turmeric contains curcumin, a chemical shown to
decrease inflammation. In traditional Eastern medicine, turmeric is used to
treat a huge range of conditions including bowel irritation, heartburn,
depression, and high cholesterol. Inflammation in the body is generally not
desirable and there don’t seem to be any downsides to taking turmeric in
moderate doses.
Indian spice with huge health benefits
Business Insider, June 2016
Turmeric’s active ingredient, curcumin, has been
suggested to treat a suite of dermatological diseases. A study done just last
month uncovered treatment in the forms of oral ingestion and topical application
showed significant improvement in skin health. Some conditions you can look
forward to possibly being relieved if you take a chance on turmeric are acne,
psoriasis, alopecia, and facial photoaging. The spice’s ingredients also provide
a potent anti-inflammatory effect. This means less swelling and pain after
irritation or injury. It has been used to significantly decrease pain and other
side effects after acute lung injury (ALI) and acute respiratory distress
syndrome (ARDS), which are both linked to high cases of mortality and hospital
treatment. Other anti-inflammatory benefits of turmeric and curcumin may include
relief from arthritis and tendinitis. And here comes the granddaddy of all news:
The curcumin in turmeric could help protect your body against cancer.
Beat the flu this winter
Health24.com June 2016
Curcumin: Studies show that a promising new
treatment for severe inflammation – which is at the heart of most chronic
diseases – is found in curcumin, a natural ingredient in the common spice,
turmeric.
Top 10 Anti-cancer Superfoods
HealthAim.com June 2016
The active ingredient found in turmeric called
curcumin is a powerful antioxidant. Researchers found that curcumin showed
anti-cancer effects at virtually all stages of tumor development.
5 Superfoods You're Probably Not Eating
Alternet.org June 2016
A member of the ginger family whose root is widely
used as an ingredient in medicines, turmeric is a superfood that has many health
properties. Since ancient times, turmeric has been used to fight inflammation, a
power given to it by the compound curcumin, which has been found to inhibit
several molecules that play a role in inflammation in human clinical trials. It
has also been used to treat a wide number of ailments, including arthritis,
heartburn, ulcerative colitis, diarrhea, high cholesterol, headaches,
bronchitis, fibromyalgia and depression. Curcumin may also help fight cancer, as
its antioxidants may help prevent free radicals from damaging cellular DNA. The
fact that its wide-ranging health properties may be used as a potential
treatment for a number of afflictions common to older people means that turmeric
isn’t just a hipster fad. “Turmeric has potential as an ingredient in
supplements and functional food and drink products, particularly within products
aimed at the growing senior population,” says Stephanie Mattucci, a global food
science analyst at Mintel. A 2012 study backs up her view. Researchers described
three patients with Alzheimer’s disease whose behavioral symptoms were “improved
remarkably” after consuming 764 milligrams of turmeric for 12 weeks. The
researchers concluded that turmeric is "effective and safe" for the treatment of
the behavioral and psychological symptoms of dementia in Alzheimer's disease
patients. (As a dietary supplement, curcumin extracts are generally preferred,
since in its raw state, turmeric has low bioavailability.)
Eating
Turmeric In Curry Could Stave Off Dementia, Study Suggests
Huffpost June 2016
The researchers found curcumin has the
potential to improve memory function for adults by blocking proteins that
destroy neurones in the brain.
Curcumin may help overcome drug-resistant
tuberculosis
Science Daily
June 2016 New
research indicates that curcumin--a substance in turmeric that is best known as
one of the main components of curry powder--may help fight drug-resistant
tuberculosis. The ability of curcumin to modulate the immune response to
Mycobacterium tuberculosis points to a potential new tuberculosis treatment that
would be less prone to the development of drug resistance. "Our study has
provided basic evidence that curcumin protects against Mycobacterium
tuberculosis infection in human cells," said Dr. Xiyuan Bai, lead author of the
Respirology study.
Turmeric: Could it help against
Alzheimer’s?
Miami Herald, June 2016
Turmeric’s power comes from the polyphenol curcumin
found in the stem of the turmeric. It has been used medicinally for more than
3,000 years for ailments as diverse as congestion, bruising and blemishes A
review of turmeric and cancer in 2014 concluded that this bright orange spice
reduced both the invasiveness and spread of cancer. A human study from this year
demonstrated that curcumin supplementation reduced the symptoms of
exercise-induced muscle damage. Curcumin is acknowledged as a potent
anti-inflammatory and antioxidant. I even came across a research article that
described this effect on children with moderate to severe asthma. In the study,
47 children with asthma were given a supplement with curcumin, resveratrol, zinc
and selenium and had reduced airway inflammation. And a study just last month in
The Journal of Alzheimer’s Disease showed that in rats with Alzheimer’s,
curcumin was neuroprotective and inhibited amyloid beta plaque accumulation.
Fight pain with food
Hippocratic Post, June 2016
Turmeric, commonly used in Indian and Thai curry
dishes has been found to have anti-inflammatory properties. Curcumin has been
found to be the main therapeutic ingredient in the spice. Research has shown
that curcumin is effective for aching joint reducing painful swelling. A Thai
study found that the spice significantly reduces the pain caused by rheumatoid
arthritis, and may be as effective as ibuprofen.
Turmeric/curcumin help skin diseases
Food Consumer, June 2016
Studies suggest that curcumin may be employed to
treat dermatologic diseases. The reviewers identified 234 articles through the
PubMed and Embase databases and reviewed 18 of them which met inclusion
criteria. Some studies investigated the effects of ingested turmeric/curcumin on
skin conditions while others looked into the effects of topically applied
turmeric/curcumin. Ten studies show that treatment with turmeric/curcumin
significantly improved skin diseases, compared with placebo. The skin conditions
considered in the studies include "acne, alopecia, atopic dermatitis, facial
photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and
vitiligo." The reviewers conclude "Overall, there is early evidence that
turmeric/curcumin products and supplements, both oral and topical, may provide
therapeutic benefits for skin health".
Spice up
your life with Turmeric
Divine.ca June 2016
1. Cancer Prevention Recent studies show turmeric is
a powerful adversary to cancer. Curcumin shows an ability to stop cancer cell
growth, boost antioxidant levels and the immune system, and kill cancer cells.
2. Promotes Weight loss and Prevents Type 2 Diabetes Helps promote weight loss
by suppressing the activity and number of immune cells in fat tissue. These are
the cells that are responsible for an increase in insulin resistance in muscles
and the liver, which stores sugars as fats in the body. Turmeric helps balance
blood sugar which in turn also prevents development of Type 2 Diabetes in those
with a diabetic disposition. 3. Relieves Arthritis Due to it’s anti-inflammatory
properties, curcurmin improves symptoms of Rheumatoid Arthritis such as pain,
inflammation and stiffness of the muscle. 4. Helps Brain Function Turmeric is
extremely healing for the brain and for increasing memory function. Some studies
say that curcurmin can help improve overall memory in Alzheimer’s patients
because of it is a source high in antioxidants. 5. Prevents Liver Disease
Turmeric is great for the liver as it protects it from the damage caused by
eating foods that contain high amounts of fat and excessive alcohol consumption.
Turmeric 'blocks the rogue proteins that
trigger Alzheimer's disease'
Daily Mail, June 2016
Cultures where curry is a staple have better
cognitive function and a lower prevalence of dementia. The yellow spice turmeric
was identified as the most probable reason for this - thanks to curcumin. The
year long trial published in the British Journal of Nutrition found evidence
curcumin blocks rogue proteins called beta amyloid which clumps together and
destroys neurons. In the study 96 participants aged between 40 and 90 were given
either a daily placebo or 1,500 mg of curcumin for 12 months. In tests of verbal
and memory skills, those taking the dummy pill suffered a decline in mental
function after just six months that was not observed in those having the
curcumin.
2016 Food
Trends on Google: The Rise of Functional Foods
ThinkWithGoogle.com June 2016
Turmeric, a spice that's purported to cure
everything from cancer to depression, is the breakout star, with searches
growing 300% over the last five years.
Turmeric can improve memory and attention in old
age, study finds
Science Alert, June 2016
"Curcumin has multiple physiological effects," said
researcher Andrew Scholey, from Swinburne University of Technology. "It’s known
to reduce inflammation and improve blood flow. It influences multiple processes
that nudge brain function in a positive direction." In their initial research,
Scholey and his team recruited 60 volunteers aged between 60 and 85, and split
them into two groups. One group was given capsules with curcumin, and the other
a placebo. The participants then completed a number of computerised mental tasks
– such as word and picture recall, simple subtraction, and reaction time tasks -
a few hours after taking the supplement, and then after taking it daily for four
weeks. Overall, the participants who’d taken the curcumin capsules performed
better at the computerised measures of working memory and vigilance. They also
reported feeling reduced fatigue as well as improved calmness, contentedness,
and stress during testing at the end of the four-week trial. "To our knowledge
this is the first study to examine the effects of curcumin on cognition and mood
in a healthy older population or to examine any acute behavioural effects in
humans," the researchers reported in the Journal of Psychopharmacology last
year. They also found that there were benefits outside of cognitive
improvements. "A significant acute-on-chronic treatment effect on alertness and
contentedness was also observed. Curcumin was associated with significantly
reduced total and LDL (low-density lipoprotein) cholesterol and had no effect on
haematological safety measures," they reported.
The Spice in Curry Can Improve Memory and Energy
Levels
The Science Explorer, May 2016
Past studies have found that older people living in
cultures where curry is a staple have better cognitive function and a lower
prevalence of dementia, and curcumin was identified as a likely reason for this.
A German study found that curcumin can act as part of the brain’s repair kit by
stimulating the growth of nerve cells. Another study published in the National
Center for Biotechnology found that curcumin can actually encourage the birth of
new brain cells, particularly in the hippocampus, a brain region that regulates
learning, memory, and mood. In a new study, the Australian researchers recruited
60 volunteers aged between 60 and 85 in order to explore how curcumin has its
effects on cognition. The volunteers were split into two groups — one was given
capsules with a curcumin formulation, and the other was given a placebo. A few
hours after taking the curcumin pill or the placebo, the participants were asked
to complete various computerized mental tasks — word and picture recall, simple
subtraction, and reaction time tasks. Following this initial experiment, the
volunteers took the curcumin supplement daily for four weeks. "To our knowledge
this is the first study to examine the effects of curcumin on cognition and mood
in a healthy older population or to examine any acute behavioural effects in
humans," the researchers report in the Journal of Psychopharmacology. At the end
of the four-week trial, the participants who had taken the curcumin capsules
performed better overall at the memory and vigilance tasks. Plus, they reported
feeling a boost of energy levels as well as lower stress and improved calmness
and contentedness. "Curcumin has multiple physiological effects," lead
researcher Andrew Scholey, director of the University’s Centre for Human
Psychopharmacology, said in a press release. "It’s known to reduce inflammation
and improve blood flow. It influences multiple processes that nudge brain
function in a positive direction."
The Health Benefits Of Turmeric: Better Than
Ibuprofen?
Inquisitr.com May 2016
"Turmeric and curcumin, the most active
constituent of the spice, have been the subject of thousands of studies. This
research shows that curcumin has potent antioxidant and anti-inflammatory
properties as well as antiviral, antibacterial, antifungal and immune modulating
activities.By helping support the body’s inflammation levels, it is a valuable
supplement for those active in sports. The repetitive trauma caused by athletic
training causes inflammation and pain that can be controlled with curcumin
(turmeric).” Turmeric grows naturally, of course, but is not well absorbed
unless taken in supplement form, according to some herbalists. This could come
by the way of teas, the roots being incorporated into smoothies, or true
curcumin supplementation, which carries enough anti-inflammatory properties to
be beneficial. As with many herbs, it is known that the benefits of turmeric are
multi-faceted; it also has been shown to decrease the risk of cardiovascular
disease and certain types of cancers. According to Shape, Maribeth Evezich,
M.S., R.D., a dietitian based in New York City, says that the powerful
anti-oxidant does have anti-inflammatory powers.
Curcumin
controls MTB infection in model
Healio.com May 2016
Researchers in this study showed an ability to
control Mycobacterium tuberculosis in a macrophage infection model using
curcumin, according to recent research. “In summary, we have shown that curcumin
can augment the ability of human macrophages to control Mycobacterium
tuberculosis (MTB) infection,” Xiyuan Bai, PhD, from the Department of Medicine
at the Denver Veterans Affairs Medical Center in Denver, Colorado, and
colleagues wrote in their study.
Using
turmeric for inflammation
Reflector.com May 2016
Curcumin is the major component of turmeric that
provides an anti-inflammatory effect. It’s an interesting herbal because it also
has antibacterial, antiviral, antifungal, antidiabetic, antifertility and
antitumor properties. In an animal study, curcumin was found to give the same
anti-inflammatory response as cortisone for acute inflammation. Taking curcumin
may be beneficial for those with osteoarthritis, RA, fibromyalgia and ulcerative
colitis.
Reasons Why
Turmeric Is the Spice Nutritionists Swear By
DivineCarlone.com May 2016
A study shows that curcumin helps your liver
metabolize cholesterol at a faster rate and also helps prevent it from
accumulating on your arterial walls. A 2013 human trial concluded that
curcumin's effectiveness in battling depression is, in fact, similar to that of
prescription anti-depressants. By increasing the release of dopamine and
serotonin—otherwise known as "feel good" neurotransmitters—concentrated doses of
curcumin can help battle depression naturally.
Amber
Wonder: The power of turmeric
On Manorama, May 2016
Studies around the world have found that curcumin
has anti-arthritic, anti-cancer, anti-viral and anti-infl ammatory properties.
“It is listed in superfoods because it is proven to be the healthiest food and
has been a part of Asian medicine for centuries,” she says. “It acts on the
biochemical processes in the body. Apart from having anti-cancer and
anti-arthritic properties, curcumin is also said to promote fat loss and prevent
cellular damage caused by the pesticides in food. “Curcumin is a powerhouse of
antioxidants, hence it is labelled as a superfood. Consuming it reduces the risk
of disease and prolongs life. It is also used in the treatment of Alzheimer’s
disease and to improve brain function. It is used as an anti-depressant, too,”
she says.
Chemical in
turmeric 'stimulates the immune system to fight drug-resistant strain'
Mail Online, April 2016
By stimulating white blood cells - a key part of the
immune system - curcumin was able to successfully remove Mycobacterium
tuberculosis from infected cells. ‘Our study has provided basic evidence that
curcumin protects against Mycobacterium tuberculosis infection in human cells.
‘The protective role of curcumin to fight drug-resistant tuberculosis still
needs confirmation, but if validated, curcumin may become a novel treatment to
modulate the host immune response to overcome drug-resistant tuberculosis.’
The Health
Benefits of Turmeric
Shape, April 2016
Turmeric and curcumin, the most active constituent
of the spice, have been the subject of thousands of studies," says Maribeth
Evezich, M.S., R.D., a dietitian based in New York City. "This research shows
that curcumin has potent antioxidant and anti-inflammatory properties as well as
antiviral, antibacterial, antifungal and immune modulating activities." You
could benefit from up to a teaspoon a day. Curcumin may also have
artery-clearing effects. In one study from Taiwan, people who consumed curcumin
extracts daily significantly reduced their levels of bad cholesterol (LDL) in
just 12 weeks.
Why turmeric
is being touted as ‘nature’s wonder drug’
JWeekly.com April 2016
The principal element in turmeric’s healing power is
curcumin, a chemical compound that is gaining popularity (especially in dietary
supplements and cosmetics) for its reported antioxidant and antiseptic
qualities. People feel that it is an invaluable tool for staving off the signs
and symptoms of aging. Curcumin also has great anti-inflammation properties and
has been found to be highly effective in helping people manage pain and
swelling. It’s used by those suffering from arthritis and joint pain, with some
saying it’s even more powerful and effective than over-the-counter pain
medications. Root and powder forms of turmeric, a relative of ginger Root and
powder forms of turmeric, a relative of ginger Curcumin also has been found to
protect the brain against diseases such as Alzheimer’s and Parkinson’s, and
assist the body in managing heart disease. Even more, preliminary studies have
found that curcumin can inhibit cancer and tumor cell growth.
Turmeric:
The wonder spice?
Xpose.ie April 2016
Scientists found that by stimulating human immune
cells called macrophages, curcumin was able to successfully remove mycobacterium
tuberculosis, the bacteria that causes tuberculosis, from experimentally
infected cells in culture. In Asia, turmeric, which comes from the root of the
Curcuma longa plant, is used as anti-inflammatory agent to treat a wide variety
of conditions, including flatulence, jaundice, menstrual difficulties,
toothache, bruises, chest pain and colic.
Curcumin can
kill the bacteria that cause drug-resistant TB
The Sun, April 2016
Turmeric is popular in Asia for treating a variety
of health conditions – as well as having anti-inflammatory and antioxidant
effects. Curcumin is a potent inducer of a mechanism used by human immune cells
to kill bacteria. In the current study, researchers tried to determine the
effects of curcumin on Mycobacterium TB and found that by stimulating white
blood cells - a key part of the immune system - curcumin was able to
successfully remove Mycobacterium tuberculosis from infected cells.
Curcumin
protects against myocardial infarction-induced cardiac fibrosis
Drug Design, Development and Therapy, April 2016
Curcumin attenuated cardiac fibrosis following MI by
regulating collagen deposition, ECM degradation, and CFs’ proliferation and
migration. The protective effects of curcumin were attributed to SIRT1
activation. The present study provides new insights into the mechanism of the
anti-fibrotic effects of curcumin in the heart. Therefore, curcumin could be
tested as an auxiliary therapeutic agent, along with classic treatments, to
improve the prognosis in patients with myocardial fibrosis after MI.
Curcumin May
Defeat Drug-Resistant Tuberculosis
Medical Daily, April 2016
Curcumin is a substance found in turmeric, a root
that’s in the ginger family and originally found in India. Curcumin is
turmeric’s most active ingredient and offers anti-inflammatory and antioxidant
properties. For centuries, turmeric has been used in both food and traditional
medicine; it’s typically boiled down, baked, and ground into a yellow powder.
Curcumin gives turmeric its yellow coloring, and as a separate entity from
turmeric is often used as an herbal supplement, or added to cosmetics, spices,
or food coloring. For thousands of years, turmeric has been used to treat
arthritis, stomach problems, and other health issues in traditional medicine and
spiritual rituals — more as an herbal supplement than anything else, of course.
In 2014, curcumin was shown to
reduce post-traumatic stress disorder (PTSD)
symptoms, and another
study found
that curcumin also held potential to shrink cancer tumors or slow their growth.
All in all,
curcumin has been studied robustly over the years,
but most of its health benefits have been played out in laboratory dishes and
have yet to be transferred to animal or human trials.
The Health
Benefits Of Curry Powder
Huffington Post, April 2016
The journal "Food and Chemical Toxicology" published
a
study
that
found that turmeric's active compound, curcumin prevented spikes in blood sugar
and improved insulin sensitivity. They concluded that the benefits of turmeric
might be due in part to anti-inflammatory effects.
Turmeric
Spice Could Fight Drug-Resistant Strains of Tuberculosis
Headlines and Global News, April 2016
The researchers tested out the effects of curcumin
in the laboratory setting and found that after stimulating macrophages, which
are cells from the body's immune system, the substance was able to remove
Mycobacterium tuberculosis, the bacterium that causes TB, through a process that
involved preventing the activation of nuclear factor-kappa B. This process
removed the bacterium from the cells that were infected during the experiment.
An addition
to efficacy of turmeric, helps fight drug-resistant TB
Zee News, April 2016
The study has further revealed that curcumin, which
is a substance in Turmeric can successfully remove Mycobacterium tuberculosis,
which happens to be the causative bacterium of tuberculosis.
Turmeric may
help overcome drug-resistant TB
The Times of India, April 2016
Curcumin--a substance in turmeric--may help fight
drug-resistant tuberculosis. Turmeric is commonly used in Indian food and is
considered to have anti-inflammatory, antioxidant, and even anticancer
properties.
Turmeric May
Help Fight Tuberculosis
NewsMax Health, April 2016
The ability of curcumin to modulate the immune
response to Mycobacterium tuberculosis points to a potential new tuberculosis
treatment that would be less prone to the development of drug resistance. Read
more: Common Spice May Aid in Fight Against TB
Turmeric can
help combat tuberculosis
LiveMint.com April 2016
According to a US study, turmeric contains a
substance called curcumin which can help fight tuberculosis. Researchers from
University of Nebraska believe curcumin, which is also responsible for the
yellow orange colour of turmeric, by stimulating immune cells called
macrophages, can successfully kill the bacteria (mycobacterium tuberculosis)
which causes tuberculosis. Turmeric is known for its anti-inflammatory,
antioxidant, and anti-cancer properties and is used for its medicinal properties
in several Asian countries. The study was published in the journal
Respirology
here.
Turmeric
Extract May Be Your Best Bet For Healing Knee Osteoarthritis
Collective Evolution, April 2016
Curcuminoid extract of turmeric reduced inflammation
in patients suffering from knee osteoarthritis.
Tumeric
Benefits: Turmeric Can Do Wonders In Your Heart and Body
Parent Herald, April 2016
The main ingredient of turmeric is the curcumin and
its yellow color gives its curry spice. Turmeric can help in maintaining the
heart health. It actually reduces the plaque build-up that can lead to the blood
clot that causes stroke or heart attack. It also lessens the cholesterol
oxidation by reducing the LDL or bad cholesterol by 56 percent and the serum
triglyceride levels by 27 percent. In addition, tumeric also lowers the total
cholesterol by 33.8 percent. Turmeric also has an anti-inflammatory and
antioxidant properties. It suppresses the COX enzyme which eases the production
of pro-inflammatory signals in the body. The antioxidants protect your body from
free radicals.
Acupuncture
Plus Curcumin Protects The Liver
Healthcare Medicine
Institute, April 2016
Acupuncture combined with oral curcumin intake
protects the liver from fibrosis. Curcumin is the chief curcuminoid in turmeric
(Jiang Huang, Rhizoma Curcumae Longae). Curcumin is bright yellow, hence the
name ginger yellow in Chinese. Jiang is translated as ginger and huang means
yellow. Curcumin is a principle polyphenol in Jiang Huang, a member of the
ginger family of herbs used for enhancing blood circulation in Traditional
Chinese medicine (TCM). The researchers concluded that acupuncture plus curcumin
“potently protected the liver” from injury and fibrogenesis. liver fibrosis.
Turmeric
holds cancer related benefits
The News Tribe, April 2016
Curcumin, a bioactive ingredient found in turmeric
(Curcuma longa) can prevent and cure bowel cancer (colorectal cancer). So far,
anti-cancer properties of curcumin were well-known but the mechanism by which
the bright yellow organic compound cures the cancer remained a mystery. The
team, headed by R Baskaran, associate professor (biochemistry and molecular
biology) at Pondicherry University, discovered the mechanism by which curcumin
kills hereditary non-polyposis colorectal cancer cells and documented their
findings. `Molecular and cellular biochemistry’, a and cellular biochemistry’, a
peer-reviewed international journal brought out by Springer Science+Business
Media, New York, published their research paper in its March, 2016 edition. The
team included Hemanth Naick, a PhD student of Pondicherry University, and
Shunqian Jin, a researcher at University of Pittsburgh cancer institute.
Curcumin in
turmeric kills colon cancer cells
Times of India, March 2016
Studies on the effect of curcumin on cancer and
normal cells will be useful for the ongoing preclinical and clinical
investigations on this potential cancer chemo-preventive agent.
Researchers
in Pondicherry University shed light on how curcumin kills tumors
The Hindu, March 2016
Curcumin, derived from the dietary turmeric (Curcuma
longa) is an effective anti-cancer, anti-inflammatory, and antioxidant agent.
Studies on the effect of curcumin on the entire cell death process, both in
tumour and normal cells, are useful for the ongoing preclinical and clinical
investigations on this potential chemo-preventive agent. While curcumin’s
chemoprevention property is well documented, its ability to kill colorectal
cancer cells is not as clearly known or understood. Although curcumin-induced
cytotoxicity is due to superoxide anion production, the precise mechanism
leading to cell death activation remains unknown. Towards this end, the research
group previously reported in a series of publications that human non-polyposis
colorectal cancer cells (HNPCC) arising due to genetic mutations in mismatch
repair genes (MMR) are highly sensitive to curcumin due to unrepaired DNA
damage. In a recent report, published in the international peer-reviewed journal
“Molecular and Cellular Biochemistry” (Feb 2016), the authors now document that
the protein levels of gadd45a (genes activated during DNA damage), are increased
following curcumin treatment. The study demonstrated how the trigger of genes is
required for cell death induced by curcumin in colorectal cancer cells and that
the mismatch repair (MMR) status strongly influences curcumin sensitivity.
Curcumin
prevents weight gain
eMaxHealth.com March
2016 Mohsen Meydani,
DVM, PhD, director of the Vascular Biology Laboratory at the USDA HNRCA
explained curcumin stopped new blood vessels from growing that make fat spread.
The mice also had lower cholesterol and less liver fat.
Health
Benefits of Turmeric
Science Mic, March 2016
Curcumin gives turmeric star qualities of being both
anti-inflammatory and an antioxidant, which means its consumers will reap
external and internal benefits, according to the Washington Post. "It is a known
fact that curcumin is a strong antioxidant compound with great ability to
scavenge the oxygen-derived free radicals," a 2013 study published in Current
Neuropharmacology said. "Consequently, curcumin could be a potential
neuroprotective agent." For joint and pain relief, these curcumin capsules were
comparable to taking ibuprofen, a 2009 study found. Turmeric has been linked to
treating a long list of diseases, such as Alzheimer's and Parkinson's due to its
ability repairing brain cells and improving memory in lab rats, the 2013 study
said. Another study found curcumin pills to assist in delaying Type 2 diabetes
compared to taking a placebo.
The curry
cure: Golden spice that could help fight cancer
Express, March 2016
“Curcumin can target a variety of processes which
are important in breast cancer development,” he says. “These include reduced
proliferation, reduction in potential to spread and increase in programmed cell
death of tumour cells.” Recent studies have found that curcumin appears to
prevent the formation of molecules that allow circulating tumour cells to spread
and attach to other body parts. It is possible that curcumin could interfere
with one of the important mechanisms of cancer development. However the benefits
of curcumin as an anti-cancer agent may not be restricted to breast well-being.
Some studies in humans and from laboratory experiments suggest potential benefit
in pancreatic cancer, colorectal cancer and lung cancer.
Curcumin
Helps Patients Tolerate Chemo
Newsmax.com March 2016
Studies have shown that curcumin not only enhances
the effectiveness of radiation treatment against the cancer, but also protects
surrounding normal cells within the treatment area.
Drug-Free
Alternatives to Treating Back Pain
Newsmax.com March 2016
Curcumin from turmeric. While turmeric has received
much attention in the alternative healthcare field, it’s actually curcumin that
has the active compounds that are most effective. It acts on multiple
inflammation pathways and neutralizes free radicals — the root causes of pain.
Curcumin has been clinically studied on its own and in combination with
boswellia for treating people with rheumatoid and osteoarthritis, as well as, or
better than, prescription drugs. Scientific studies of human spinal discs
treated with curcumin showed an 80 percent reduction in inflammatory compounds
and a 70 percent reduction in cartilage-damaging enzyme activity.
Curcumin may
prevent liver damage from acetaminophen / paracetemol
J Pharm Pharmacol. March
2016 Curcumin
prevented acetaminophen-induced liver damage. Curcumin lessened
acetaminophen-induced liver histological damage and increment in plasma alanine
aminotransferase and aspartate aminotransferase activity. Additionally, curcumin
reduced the decrease in oxygen consumption measured using either succinate or
malate/glutamate as substrates (evaluated by state 3, respiratory control ratio,
uncoupled respiration, and adenosine diphosphate/oxygen ratio), in membrane
potential; in ATP synthesis; in aconitase activity; and in the activity of
respiratory complexes I, III, and IV. These results indicate that the protective
effect of curcumin in acetaminophen-induced hepatotoxicity is associated with
attenuation of mitochondrial dysfunction.
Effect of
turmeric on colon histology
BMC Complementary and Alternative Medicine, March
2016 improved body
weight gain, mean macroscopic and microscopic ulcer scores in the colon of rats
suffering from acetic acid-induced IBD. CL reduced both MPO and IL-23 in the
mucosa of the colon. The increase in the mean serum glutathione level may help
in the reduction of oxidative stress associated with IBD.
Expert backs
three spices in diet to keep cancer away
Times of India, February 2016
Curcumin proved to be more effective at reducing
inflammation than over-the-counter aspirin and ibuprofen, and as effective as
the more powerful drug Celebrex. It also proved as effective in thwarting breast
cancer cells as tamoxifen, a drug widely used to stop its spread or recurrence.
7 ways
turmeric can change your life
Daily O, February 2016
The general consensus is that curcumin, a component
of turmeric is the protective agent here. It improves memory, focus and
cognition too by increasing the growth of new neurons and fighting various
degenerative processes in the brain.
Your Health:
Why is everyone raving about turmeric?
NZ Herald, February 2016
Modern scientific research is now confirming what
traditional medicine has known - turmeric (and curcumin, the active constituent)
has beneficial actions on many bodily systems. Recent studies have revealed
turmeric has a wide range of pharmacological and clinical properties, including
as an antioxidant, digestive, anti-inflammatory, antiplatelet (decreases
clotting), cholesterol lowering and anti-carcinogenic.
What Will
Curcumin Do For Me? Stuart’s Dr. True Has The Answer
Stuart Magazine, February 2016
Curcumin is the active component of the spice called
turmeric. It has been in use as a spice and traditional medicine for more than
2,500 years. Turmeric is found throughout the world and has a unique name in
more than 60 languages. The curcumin extract of turmeric is not new; it was
first isolated in 1842. Recent scientific discoveries have confirmed that
curcumin may have amazing anti-inflammatory and disease-inhibiting properties.
It has the potential to inhibit the growth of many types of cancer, reverse
insulin resistance in Type 2 diabetes, inhibit plaque formation in
atherosclerosis and address factors that stop the development of Alzheimer's
disease. These are just a few of the diseases and maladies that have been
researched in the last decade in which curcumin was found to have a positive
impact.
Curcumin
boosts effect of training on muscles
Ergo-Log.com February 2016
Athletes looking to extend their endurance capacity
may achieve better results by taking high doses of curcumin. And curcumin
supplementation may also help people who are trying to lose weight by doing
intensive cardio training.
Turmeric
offers a wide range of health benefits
ConsumerAffairs.com January 2016
As one of the most thoroughly researched plants
ever, there are currently 8,421 peer-reviewed articles published which claim to
prove the numerous benefits of turmeric. Benefits Packed with
anti-inflammatories and antioxidants, turmeric has been shown to fight free
radicals, rejuvenate the cells, cleanse the liver, protect the heart, boost
mood, and support the brain. It may also be helpful in treating osteoarthritis,
viral and bacterial infections, stomach ulcers, cancer, and other conditions.
“It’s a very powerful plant,” says Natalie Kling, a Los Angeles-based
nutritionist who recommends it to clients for joint pain. Kling says that when
taken as a supplement, it helps quickly.
Curcumin
Shows Promise as Depression Treatment
Psychiatric Advisor, January 2016
“Curcumin does have an effect on several
physiological systems that are implicated in the causes of depression,” Roger S.
McIntyre, MD, a professor of psychiatry and pharmacology and head of the Mood
Disorders Psychopharmacology Unit at the University of Toronto, told Psychiatry
Advisor. “It certainly would be a reasonable hypothesis that it could be in
possession of antidepressant properties.” One recent study finding support for
the antidepressant effects of curcumin was published in October 2014 in the
Journal of Affective Disorders.2 In the randomized, double-blind,
placebo-controlled trial, researchers from several universities in Australia
assigned 56 patients with MDD to receive either curcumin or placebo capsules
twice a day for 8 weeks. Until the fourth week, each group had similar
improvements in scores on the Inventory of Depressive Symptomatology self-rated
version (IDS-SR30). From the fourth week through the eighth week, however, there
was a significantly greater improvement in scores in the curcumin group,
especially among patients with atypical depression. “Curcumin can influence
several mechanisms in the body; in particular, it is a powerful natural
anti-inflammatory and antioxidant,” study co-author Adrian Lopresti, PhD, a
clinical psychologist and researcher at the School of Psychology and Exercise
Science at Murdoch University, told Psychiatry Advisor. “This has relevance to
depression because people with depression have greater inflammation and
oxidative stress, which can affect all major organs in the body, including the
brain.” Chronic inflammation can decrease levels of serotonin and dopamine and
lead to degeneration in certain brain areas. It is possible that the antioxidant
and anti-inflammatory effects of curcumin can restore these neurotransmitters
and protect the brain, eventually leading to improvements in mood.
Fight
depression with turmeric
TheHealthSite.com January 2016
A dose of curcumin increases serotonin as well as
dopamine levels in the brain. An imbalance in serotonin levels influences the
mood, which can eventually lead to depression, while dopamine is a
neurotransmitter that helps control the brain’s reward and pleasure centers.
The
anti-inflammatory role of curcumin in obesity and obesity-related metabolic
diseases
European Journal of Nutrition
School of Life Sciences, College of Natural
Sciences
Researchers reviewed
the last
ten years of curcumin science
as it applies to supporting weight loss and preventing obesity-related
disease. Their conclusion is, “The modulation of several cellular
transduction pathways by curcumin has recently been extended to elucidate
the molecular basis for obesity and obesity-related metabolic diseases.
These findings might enable novel phytochemical treatment strategies as well
as curcumin translation to the clinical practice for the treatment and
prevention of obesity-related chronic diseases. Furthermore, the relatively
low cost, safety and proven efficacy of curcumin make it advisable to
include curcumin as part of healthy diet.”
Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin
and Other Nutraceuticals
Cytokine Research Laboratory, Department of
Experimental Therapeutics, The University of Texas M. D. Anderson Cancer
Center, Houston, Texas 77030
Extensive research within the past two
decades has revealed that obesity, a major risk factor for type 2 diabetes,
atherosclerosis, cancer, and other chronic diseases, is a proinflammatory
disease. Several spices have been shown to exhibit activity against obesity
through antioxidant and anti-inflammatory mechanisms. Among them, curcumin,
a yellow pigment derived from the spice turmeric (an essential component of
curry powder), has been investigated most extensively as a treatment for
obesity and obesity-related metabolic diseases. Curcumin directly interacts
with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and
muscle cells. There, it suppresses the proinflammatory transcription factors
nuclear factor-kappa B, signal transducer and activators of transcription-3,
and Wnt/β-catenin, and it activates peroxisome proliferator-activated
receptor-γ and Nrf2 cell-signaling pathways, thus leading to the
downregulation of adipokines, including tumor necrosis factor,
interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the
upregulation of adiponectin and other gene products. These curcumin-induced
alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and
other symptoms linked to obesity.
Pharmacological basis for the role of curcumin
in chronic diseases: an age-old spice with modern target- Bokyung Sung
Cytokine Research Laboratory, Department of
Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center,
Houston, TX 77030, USA
Curcumin
(diferuloylmethane), a yellow pigment in the spice turmeric (also called
curry powder), has been used for centuries as a treatment for inflammatory
diseases. Extensive research within the past two decades has shown that
curcumin mediates its anti-inflammatory effects through the downregulation
of inflammatory transcription factors (such as nuclear factor κB), enzymes
(such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor
necrosis factor, interleukin 1 and interleukin 6). Because of the crucial
role of inflammation in most chronic diseases, the potential of curcumin has
been examined in neoplastic, neurological, cardiovascular, pulmonary and
metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin
have been examined in animals and in humans. Various pharmacological aspects
of curcumin in vitro and in vivo are discussed in detail.
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Spice Rack...Or Medicine Chest?
Nutrition Action Health Letter
"Curcumin protects the brain cells in
every animal model of traumatic brain injury, whether it's stroke,
Alzheimer's disease, Huntington's disease, or mad cow disease," says
Gregory Cole, associate director of the Alzheimer's Disease Center
at the University of California, Los Angeles. "What's unique about
Curcumin," Cole notes, "is that it binds directly to beta-amyloid
deposits in the brain and reduces their size." Beta-amyloid is a
protein fragment that builds up between brain cells of people with
Alzheimer's disease....
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Science Daily Magazine
How
Plants Protect Us From Disease
"Everyday
foods, beverages, and spices contain healthful compounds that help
us fight harmful inflammation. And, in doing that, these
phytochemicals may also reduce our risk of diseases associated with
chronic inflammation, including cancer and diabetes."
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Curry Power
Science News Magazine
"The list of Curcumin's effects goes on
and on, and they're all in your favor...in addition to its
anti-inflammatory and antioxidant properties, Curcumin has several
effects that may work in tandem to protect the brain from plaques in
other ways. "If Curcumin had a single molecular target, it probably
would not be as good a drug," M.D. Anderson Cancer Center in
Houston. "But because it has multiple targets, it's very
attractive."
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Curcumin at M.D. Anderson Cancer Center
The University of Texas, MD Anderson
Cancer Center
Curcumin has been shown to prevent a
large of number of cancers in animal studies. Laboratory data
indicate that Curcumin can inhibit tumor initiation, promotion,
invasion, angiogenesis and metastasis. Epidemiological evidence
indicate that incidence of certain cancers is less in people who
consume Curcumin than in those who do not. Recent evidence indicates
that, besides chemopreventive activity, Curcumin may also be
effective in the treatment of cancer. Curcumin is currently under
investigtion for its anti-cancer and anti-inflammatory effects at M.
D. Anderson Cancer Center and other medical institutions.
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Spice Healer
Scientific
American Magazine
An ingredient in curry shows promise for
treating Alzheimer's, cancer and other diseases.
"A chapter in a forthcoming book, for
instance, describes the biologically active components of
Turmeric--Curcumin and related compounds called Curcuminoids--as having
antioxidant, anti-inflammatory, antiviral, antibacterial and antifungal
properties, with potential activity against cancer, diabetes, arthritis,
Alzheimer's disease and other chronic maladies. And in 2005 nearly 300
scientific and technical papers referenced Curcumin in the National
Library of Medicine's PubMed database, compared with about 100 just five
years earlier. Scientists who sometimes jokingly label themselves
Curcuminologists are drawn to the compound both because of its many
possible valuable effects in the body and its apparent low toxicity.
They ponder how the spice or its derivatives might be used, not just as
a treatment but as a low-cost preventive medication for some of the most
feared ailments. As a treatment, it also has some enticing attributes.
Because Curcumin targets so many biological pathways, it could have
benefits for cancer therapy: malignant cells may be slow to acquire
resistance to it and so might have to go through multiple mutations to
avoid the substance's multipronged attack."
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Prevent Cancer, Heart Disease
NewsMax.com December 2015
Many studies have shown that curcumin, the active
ingredient in turmeric, protects against many diseases including cancer and
Alzheimer's. A study at the University of California, Los Angeles, found
curcumin slows the buildup of amyloid plaques — one of the hallmarks of
Alzheimer's — in the brain, and a laboratory study at the University of
Illinois revealed that curcumin protected cells from damage caused by
beta-amyloid. Latest News Update Get Newsmax TV At Home » Special:
Researchers at Johns Hopkins University Medical School showed that curcumin
protected against the nerve cell damage associated with Parkinson’s disease,
and numerous studies have shown curcumin fights many types of cancer
including colon, pancreatic, and breast. Read more: Prevent Cancer, Heart
Disease With Ethnic Cuisine
Help for depression and anxiety
EveryDayHealth.com December 2015
Curcumin helps mitigate depression and anxiety.
The abstract from a 2014 study in the Journal of Affective Disorders reads:
Curcumin, the principal curcuminoid derived from the spice turmeric,
influences several biological mechanisms associated with major depression,
namely those associated with monoaminergic activity, immune-inflammatory and
oxidative and nitrosative stress pathways, hypothalamus-pituitary-adrenal
(HPA) axis activity and neuroprogression. We hypothesised that curcumin
would be effective for the treatment of depressive symptoms in individuals
with major depressive disorder.
Arthritis help may come from a surprising source
Clinton Herald, December 2015
Curcumin, the active chemical in the spice
turmeric, has several potential uses. I wrote some months ago about its
possible use in inflammatory bowel disease, but I was able to find several
studies showing benefit in people with both osteoarthritis and rheumatoid
arthritis. The usual dose was 500 mg (of curcumin) two or three times daily.
There were few side effects in the studies, but there is the potential to
worsen bleeding in people taking anticoagulants, such as warfarin. Curcumin
seems a reasonable alternative to anti-inflammatories in people with
arthritis, and it might be worth a trial, especially in people who
experience side effects on the standard drugs. As always, finding a
high-quality product is essential, since supplements are largely
unregulated.
Turmeric for Alzheimer's Disease
About.com Health, December 2015
Turmeric contains a class of compounds called curcuminoids, which include a
substance known as curcumin. Known to possess antioxidant properties,
curcumin may play a key role in turmeric's potential effects against
Alzheimer's disease. Preliminary research indicates that the curcumin found
in turmeric may help curb inflammation and combat oxidative stress, two
factors found to contribute to the development of Alzheimer's disease.
What's more, some preliminary studies suggest that curcumin may help thwart
the Alzheimer's-associated breakdown of nerve cells in the brain. There's
also some evidence that turmeric may inhibit the formation of
Alzheimer's-related brain plaques. Known to accumulate between nerve cells,
these plaques form when protein fragments called beta-amyloid clump
together. Beta-amyloid also appears to impair brain function by destroying
synapses (structures through which nerve cells transmit signals to one
another). In several animal-based studies, scientists have observed that
turmeric may help clear beta-amyloid from the brain. For example, a
mouse-based study published in Current Alzheimer Research in 2012 found that
treatment with turmeric extract significantly reduced brain levels of
beta-amyloid in mice genetically engineered to develop symptoms of
Alzheimer's.
The link between cancer and diet
The News Tribe, December 2015
Curcumin,
anti-ageing factor in this wonder spice. Renders anti-inflammatory and
antioxidation benefits, hence used traditionally for a healthy glowing skin.
Besides, it also destroys pro-carcinogens, thus protecting against cancer.
It is also seen as that inclusion of turmeric in the diet reduces the
incidences of senile diseases like Alzheimers.
Curcumin supplementation likely attenuates
delayed onset muscle soreness (DOMS).
Eur J Appl Physiol, December 2015
Oral
curcumin likely reduces pain associated with DOMS with some evidence for
enhanced recovery of muscle performance. Further study is required on
mechanisms and translational effects on sport or vocational performance.
Liver Health
LiveSupport.com November 2015
Turmeric’s primary chemical compound is curcumin, a yellow substance with a
long history of aiding liver health. Numerous studies have linked curcumin
to reductions in liver cancer and liver fibrosis. According to a study in a
2012 edition of the Journal of the Medical Association of Thailand,
scientists found that the livers of diabetic rats were repaired and even
regenerated with the help of turmeric. According to a 2009 study in the
journal Liver International, curcumin showed an ability to inhibit several
factors (like nuclear factor-kappaB) that helped reduce liver inflammation.
In addition, the authors found that curcumin helped protect against liver
injury from known liver cell toxins.
Phytonutrients
LiveScience.com November 2015
Curcumin is found primarily in turmeric, a member
of the ginger family. It gives turmeric its distinctive yellow color.
Because of its curcumin, turmeric has been used as a medicinal remedy in
India for centuries, said Premkumar. “The claimed effects of curcumin range
from relieving flatulence to curing Alzheimer’s disease and cancer,” said
Premkumar. Animal studies have shown good results when looking at oral
administration of curcumin and to inhibit the spread of mouth, stomach,
liver and colon cancer. Studies are under way to investigate this effect in
humans. Curcumin is an effective anti-inflammatory agent and antioxidant. It
may also affect carcinogen metabolism, helping the body get rid of toxic
compounds, and aid in combating cancer cell growth and tumors, according to
the Linus Pauling Institute. All of these factors contribute to its being a
potentially effective cancer-prevention agent. Based on successful animal
trials, it has been suggested that curcumin could aid in inflammatory
diseases like rheumatoid arthritis as well as cystic fibrosis and
Alzheimer’s disease, but studies are either not yet under way or are
inconclusive, according to the Linus Pauling Institute. According to
Premkumar, curcumin can also be helpful in cardiovascular protection by
lowering LDL cholesterol levels and increasing HDL (good) cholesterol
levels. “Treatment with curcumin selectively increases the expression of
low-density lipoprotein (LDL) receptor levels and is able to clear LDL,
which is bad or lousy cholesterol,” he said.
Possible BPH Therapy Seen in Using Curcumin as
Dietary Supplement
BPH News, November 2015
Recent research revealed curcumin significantly
decreases prostate weight and volume in animal models of benign prostatic
hyperplasia (BPH). The study entitled “Inhibitory effect of curcumin on
testosterone induced benign prostatic hyperplasia rat model” was published
in the journal BMC Complementary and Alternative Medicine. Benign prostatic
hyperplasia (BPH) is a common condition affecting elderly men and is
characterized by a hyperplastic growth of the prostate gland, causing
pressure on the bladder and urethra. Curcumin, one of the primary
ingredients in turmeric and curry powders, and with beneficial effects in
several diseases including retinal diseases and Parkinson’s disease, was
also suggested to enhance degradation of a key receptor in prostate cancer
and induce cancer cell death. The team observed that curcumin inhibited the
development of BPH, significantly lowering prostate weight and volume.
Additionally, authors observed curcumin decreased expression of VEGF,
TGF-ß1, and IGF1 when compared to the control group (important growth
factors in prostate tissue). These findings suggest that curcumin could
potentially be used as an herbal treatment or functional food for BPH
management, this way bypassing the adverse side effects observed in commonly
used treatments for the condition.
Maintain liver health with curcumin
ChiroEco.com November 2015
Curcumin is the main component of the spice
turmeric, giving it a distinctive bright golden coloring. Turmeric is a
member of the ginger family and often used as a staple in Indian cooking,
particularly as a primary ingredient in curry. Curcumin is thought to
prevent the accumulation of fatty acids in the liver, thereby staving off
the possibility of NAFLD before it progresses to NASH as well as other liver
diseases. Furthermore, curcumin is a powerful antioxidant, so it may also
protect against the effects of age on the liver, as well as inhibit the
formation of enzymes that can cause cellular death. A 2015 review discussed
curcumin’s role in preventing NASH. The study found that curcumin inhibits
the activation of hepatic stellate cells, which form scars in the liver
following damage.
Turmeric for disease prevention
examiner.com November 2015
Turmeric is
made up of compounds called curcuminoids, named for the most well known and
main active compound, curcumin. Curcumin is a strong antioxidant and
arguably the most effective anti-inflammatory compound, not only fighting
inflammation when it occurs, but stopping at the source, before it even
begins. It is now believed that every chronic disease, including heart
disease, thyroid disease and diabetes, has a strong correlation with chronic
internal inflammation that you may not know even exists in your body. That
said, regulating your body’s silent inflammatory response by utilizing
turmeric and curcumin not only helps manage chronic disease, but is an
important disease preventative. In fact, curcumin is so powerful that it is
said to rival some anti-inflammatory drugs, even preventing fat accumulation
and rebound, a common symptom of chronic inflammation. That is because of
it’s anti-angiogenic properties and it’s ability to lower cholesterol
levels, thusly reducing overall weight loss.
Turmeric prevents fear from being stored in the
brain
Mail Online, November 2015
A spice commonly used in curry could help erase
bad memories, according to a study. Curcumin, a bright-yellow compound found
in the root of the Indian spice turmeric, prevented new fear memories being
stored in the brain, and also removed pre-existing fear memories,
researchers found. It is hoped that the findings will help develop
treatments for people suffering with psychological disorders. Psychologists
from the City University of New York trained rats to become scared when they
heard a particular sound. Scientists assumed the creatures were frightened
when they froze. Hours later, when the same sound was played to the rats,
those who had been given ordinary food froze. Yet the rats fed the
curcumin-rich diet didn’t freeze, suggesting their fearful memories had been
erased. Professor Glenn Schafe, who led the study, said: ‘This suggests that
people suffering from post-traumatic stress disorder and other psychological
disorders that are characterised by fearful memories may benefit
substantially from a curcumin-enriched diet.’
Health Benefits of Curcumin
BT.com November 2015
Curcumin, a
substance found in turmeric, is thought to reduce swelling and ease the pain
associated with inflammation of the joints. Curries may help to prevent
Alzheimer’s… Researchers have found that curcumin can also reduce the
build-up of plaques on the brain that cause Alzeihmer's by as much as 50%.
…And cancer Turmeric has been found to reduce the risk of several types of
cancer; while a study found that people consuming high levels of cumin were
less likely to develop prostate cancer.
Turmeric is hot and may benefit more than just
your taste buds
Today, October 2015
Many of the studies have focused on curcumin,
which researchers say is the active ingredient in turmeric. A Thai study
published in 2014 found that curcumin capsules dulled the pain in arthritic
knees just as well as the popular OTC NSAID ibuprofen. A 2015 study in a rat
model of Alzheimer's disease found that the spice improved working memory.
In fact, the more curcumin the rats consumed, the better their memories got.
The super healthy trendy root
Today, October 2015
Turmeric is getting lots of attention because the
active ingredient in it, curcumin, has potent anti-inflammatory properties
and has been shown to be beneficial in treating symptoms of Crohn's disease,
Irritable Bowel Syndrome and stomach ulcers. There is also research (in both
animals and humans) that shows that curcumin may help prevent and slow the
spread of cancer, make chemotherapy more effective and protect healthy cells
from radiation damage.
Health
benefits of turmeric
The Gleaner, October 2015
Turmeric's unique contribution to
prostate-cancer-fighting is its extraordinary anti-inflammatory properties,
provided chiefly by its natural primary component, curcumin. Reducing
inflammation with curcumin reduces the metastases that ultimately kill
prostate cancer patients. Curcumin also down-regulates genes involved in
adhesion, motility, and invasiveness that prostate-cancer cells need to
invade and spread. Curcumin specifically inhibits prostate cancer-cell
production of PSA by blocking its genetic expression. At the same time, it
also reduces activation of the androgen receptors on cancer cells that
trigger increased production of PSA. But the whole turmeric root also
contains important oils and other substances that enhance curcumin's
absorption and have health benefits of their own, including anti-cancer
actions. Turmeric also inhibits the growth of stem cells that give rise to
breast cancer without harming normal breast cells.
The beneficial role of curcumin on inflammation,
diabetes and neurodegenerative disease: A recent update
Food and Chemical Toxicology, October 2015
Naturally occurring polyphenols (like curcumin,
morin, resveratrol, etc.) have gained importance because of their minimal
side effects, low cost and abundance. Curcumin (diferuloylmethane) is a
component of turmeric isolated from the rhizome of Curcuma longa. Research
for more than two decades has revealed the pleiotropic nature of the
biological effects of this molecule. More than 7000 published articles have
shed light on the various aspects of curcumin including its antioxidant,
hypoglycemic, anti-inflammatory and anti-cancer activities. Apart from these
well-known activities, this natural polyphenolic compound also exerts its
beneficial effects by modulating different signalling molecules including
transcription factors, chemokines, cytokines, tumour suppressor genes,
adhesion molecules, microRNAs, etc. Oxidative stress and inflammation play a
pivotal role in various diseases like diabetes, cancer, arthritis,
Alzheimer's disease and cardiovascular diseases.
Researchers
make breakthrough in understanding cancer
The Eagle, October 2015
Long-chain omega-3 fatty acids found in fish oil,
as well as curcumin, found in turmeric, are in a unique class of dietary
bioactives that we have termed membrane-targeted dietary bioactives, or
MTDBs. Previous studies suggest that dietary bioactives such as curcumin, as
well as fish oil and omega-3 fatty acids, are effective as colorectal cancer
preventive agents. Long-chain fatty acids found in fish oil, as well as
curcumin and capsaicin, which is found in hot peppers, fall into this unique
class because they have both hydrophilic, or water-loving, properties and
lipophilic, or fat-loving, properties. Due to their characteristics, these
are capable of disturbing cell membrane organization. Membrane-targeted
dietary bioactives, such as curcumin and capsaicin, squeeze in between
spaces within the membrane leading to disruption of lipid and protein
interactions.
Curcumin supplementation: more glycogen, less
lactic acid, more stamina, more strength
Ergo-log.com September 2015
Curcumin [structural formula shown below] has been
the subject of heated interest from molecular nutritionists in recent years.
That's not surprising if you look at the long list of the benefits of
curcumin: it inhibits muscle breakdown, enhances the positive effects of
exercise on the blood vessels, boosts testosterone levels, inhibits
estradiol, strengthen bones
5 Secret Health Benefits of Spicy Food
Desi Blitz, September 2015
Curcumin in particular is said to have
anti-inflammatory properties, which break down the bad brain cells linked to
Alzheimer’s disease.
Turmeric Blocks Cancer Cells – Which Chemotherapy
Can’t Do
Food
World News, September 2015
A recent study published in the Asian Pacific
Journal of Cancer Prevention, for instance, found that a dose-dependent
administration of curcumin effectively activated apoptosis of liver cancer
cells, meaning it prompted these harmful cells to die.
How to improve your circulation
Stuff.co.nz, September 2015
Ginger, similar to spicy peppers, can help blood
flow, as can turmeric root, which also has anti-inflammatory properties.
Turmeric contains curcumin, which is not only a wonderful antioxidant, it
also assists blood flow.
Curcumin inhibits
Lab Invest,. September 2015
These findings characterized a novel mechanism by
which curcumin modulated hepatocyte EMT implicated in treatment of liver
fibrosis
A glass of turmeric
DailyTimes.com September 2015
The major medicinal value and health benefits of
turmeric are due to its main ingredient curcumin. Curcumin serves as an
anti-inflammatory agent and also possess anti-bacterial and anti-viral
properties. These properties make it a powerful healing agent in conditions
like common cold. The anti-inflammatory action of curcumin aids in relieving
the chest congestion which typically accompanies common cold. Curcumin also
helps in boosting immunity and hence makes children less susceptible to such
infections. When taken with milk, the absorption of curcumin in the body is
enhanced significantly leading to a quick relief from common cold.
Focus on herbs that can treat diabetes
TheHindu.com August 2015
The most
active component of turmeric is curcumin, a potential therapeutic agent used
in diabetes and related complications. Curcumin could alleviate most aspects
of diabetes including insulin resistance, hyperglycemia, hyperlipidemia,
islet apoptosis and necrosis effectively. Moreover, Curcumin is safe and
relatively inexpensive.
Three reasons turmeric is a boon for diabetics
TheHealthSite.com August 2015
The
antioxidant, antimicrobial, anti-inflammatory, and anti-glycaemic properties
of curcumin present in turmeric, helps to strengthen the immune system and
fight various infections and viruses. Here are some natural remedies that
help you boost immunity and stay safe. It helps in weight management:
Obesity is a major risk factor of diabetes, accumulation of abdominal fat
makes insulin production difficult. However, curcumin helps to control
triglyceride and cholesterol levels in the body, improve digestion, prevent
the accumulation of harmful fats. This helps in weight management, an
important way to manage diabetes or prevent its onset.
Top 10
super-spices
Madison.com August 2015
Curcumin
is more effective slowing down the development of Alzheimer’s disease than
many medications, because it decreases inflammation and oxidation in the
brain. This spice also speeds up the recovery time from strokes as well.
Turmeric and its active ingredient, curcumin, are also highly effective
against diseases like irritable bowel disease, ulcerative colitis, Crohn’s,
and arthritis. Turmeric also improves liver function, lowers homocysteine
and prevents heart disease.
Curcumin shows promise for treatment of
mild-to-moderate ulcerative colitis
Healio.com August 2015
“The findings of
this trial suggest that curcumin as add-on therapy with optimized mesalamine
is superior to optimized mesalamine alone in inducing clinical remission in
patients with active mild-to-moderate UC,” the researchers concluded.
New Findings Support Curcumin as Derivative for
Use in Fighting Mesothelioma
MesotheliomaHelp.com August 2105
According to researchers from
Flinders Medical Centre, a teaching hospital and medical school in South
Australia, curcumin, the active ingredient in turmeric and the spice that
gives curry its yellow color, inhibited the growth of mesothelioma tumor
cells in human patient cells. Prior research was focused on animal models.
“Curcumin – which can be taken orally in tablet form – has virtually no side
effects, and could be used alone in patients too unwell to tolerate other
therapies, or in conjunction with other drugs,” said lead researcher and
Associate Professor Sonja Klebe, from the Department of Anatomical Pathology
at Flinders, in a July 2 article in The Lead. “It may improve treatment
response and allow reduction of standard drugs, improving quality of life,”
added Klebe... The researchers found that the spice helps combat the cancer
by directly affecting the blood supply to the tumors.
3 Reasons to Include Turmeric in Your Diet
US News & Health Report, August 2015
The magic of turmeric resides in the roots,
specifically in the chemical compound called curcumin. Curcumin is a
polyphenol – a chemical compound found in plants with antioxidant properties
and myriad therapeutic attributes. In 2007, a study in Advances in
Experimental Medicines and Biology, went so far as to state that, "Curcumin
has been shown to exhibit antioxidant, anti-inflammatory, antiviral,
antibacterial, antifungal and anticancer activities, and thus has a
potential against various malignant diseases, diabetes, allergies,
arthritis, Alzheimer's disease and other chronic illnesses."
Turmeric Rx: Centuries-old Indian spice may have
multiple health benefits
Pittsburgh Post-Gazette, August 2015
Curcumin can help prevent or treat a wide
spectrum of cancers, inflammatory conditions, autoimmune problems,
neurological ailments including Alzheimer’s disease, cardiovascular disease,
diabetes and diabetes neuropathy, among other metabolic diseases. Interest
in turmeric and curcumin began decades ago when researchers began asking why
India has some of the lowest rates of colorectal, prostate and lung cancer
in the world, compared with the United States, whose rates are up to 13
times higher. They traced India’s advantages largely to its diet staple of
curry powder, which is a combination of spices, with turmeric as a main
ingredient. A recent review published in the journal Molecules said studies
to date “suggest that chronic inflammation, oxidative stress and most
chronic diseases are closely linked, and that antioxidant properties of
curcumin can play a key role in the prevention and treatment of chronic
inflammation diseases.” An M.D. Anderson Cancer Center review of curcumin
research, in the journal Phytotherapy Research in 2014, found that it
regulates inflammation that “plays a major role in most chronic illnesses,
including neurodegenerative, cardiovascular, pulmonary, metabolic,
autoimmune and neoplastic diseases.” Yet another M.D. Anderson study found
that curcumin exhibits “antioxidant, anti-inflammatory, antiviral,
antibacterial, antifungal, and anticancer activities,” all bolstering its
“potential against various malignant diseases, diabetes, allergies,
arthritis, Alzheimer’s disease and other chronic illnesses.”
Exciting research shows curcumin spice could help
treat mesothelioma
EmaxHealth.com
July 2015
Curcumin is known for its anti-inflammatory and
anti-cancer properties. The turmeric derivative has the ability to stop the
growth of mesothelioma, found in animal lab experiments. Now researchers
have taken things a step further by testing curcumin's anti-cancer effect in
human mesothelioma cells Associate Professor Sonja Klebe, from the
Department of Anatomical Pathology at Flinders Medical Centre said in a
media release: “Importantly, this breakthrough allows us to predict if a
certain patient is likely to benefit from therapy.” Advertisement Current
therapy for mesothelioma involves trying to keep the cancer from growing and
spreading to other organ. Surgery is not an option for everyone.
Chemotherapy has been only partially successful. Curcumin halts blood supply
to mesothelioma tumors Klebe explained curcumin has the ability to stop new
blood vessels from growing. Cutting off the blood supply to cancer has been
a focus of treatment. But the researchers were able to show for the first
time that mesothelioma cells form 3-dimensional tubes. “This may explain the
poor results of trials with the standard drugs, because they do not target
this type of blood vessel formation," Klebe says. The researchers thinks
curcumin has a direct affect on mesothelioma tumor growth in addition to
stopping blood vessels from growing. “Curcumin – which can be taken orally
in tablet form - has virtually no side effects, and could be used alone in
patients too unwell to tolerate other therapies, or in conjunction with
other drugs. It may improve treatment response and allow reduction of
standard drugs, improving quality of life,"
Treating Mesothelioma with Curcumin: Success May Be Predictable
SurvivingMesothelioma.com July 2015
Curcumin is the plant polyphenol that gives turmeric its yellow hue and
spicy flavor. It has anti-inflammatory properties and has been shown to
inhibit the growth of mesothelioma cells from animal models in the
laboratory. Now, for the first time, researchers in Australia say they have
successfully done the same thing with human cells taken from their own
mesothelioma patients. Researcher Sonja Klebe, an Associate Professor at
Flinders Medical Centre in South Australia where the new research was
conducted, says the breakthrough will allow doctors to predict whether or
not a certain mesothelioma patient will benefit from treatment with
curcumin. The research at Flinders may also help explain why curcumin may
sometimes work even better than traditional drugs to fight mesothelioma. Dr.
Klebe says she and her research colleagues have discovered, for the first
time, that mesothelioma cells may be capable of giving rise to their own
blood vessels to feed growing tumors. Traditional mesothelioma medications
only target blood vessel growth arising from surrounding stromal cells.
“This may explain the poor results of the standard drugs because they do not
target this type of blood vessel formation,” explains Dr. Klebe. Unlike
these drugs, curcumin does appear to impact this type of blood vessel
formation, potentially slowing or even reversing the growth of mesothelioma
tumors. Curcumin can be taken in a pill form and has virtually no side
effects. If the new research findings can be confirmed, Dr. Klebe says
curcumin could be added to the standard treatment regimen for some
mesothelioma patients, making it possible to reduce the amount of
side-effect producing medications they have to take. Mesothelioma is an
extremely rare and hard-to-treat cancer affecting an estimated 2,500
American patients every year. It is directly liked to asbestos exposure.
Spicy
treatment for aggressive cancer
Southern Health News, Flinders Medical Center Publication, July 2015
Scientists at Flinders Medical Centre say they have successfully used the
plant polyphenol curcumin to slow the growth of mesothelioma cells taken
from their own patients. To understand how this new research may impact
future treatment, click here to read the article Surviving Mesothelioma has
just posted. Curcumin comes from the plant that produces the spice turmeric.
Although it has been used to slow the growth of mesothelioma cells taken
from animal models, the new research represents the first time the same
thing has been done with cells from human mesothelioma patients.
Rediscovering the Cancer-Fighting Power of
Turmeric
Asbestos.com July 2015
Historical evidence dating back thousands of years shows people in China and
India often used curcumin to treat a number of conditions, from coughs and
colds to skin diseases and wounds. Although it's been touted for its
anti-inflammatory and antioxidant properties, tests to confirm further
medicinal properties over the last few decades show mixed results. But the
popular spice is back in the limelight thanks to modern clinical trials
evaluating the compound's cancer-fighting properties. Clinical Trials
Involving Curcumin and Cancer Many studies have shown curcumin can suppress
tumor cells and is safe to consume even at high doses. Researchers at Case
Western Reserve University School of Medicine in Ohio and Georg-Speyer-Haus
research institute in Frankfurt, Germany, published a study in September
2014 titled, "Curcumin, Special Peptides Boost Cancer-Blocking PIAS3 to
Neutralize Cancer-Activating STAT3 in Mesothelioma." The study on tissue
samples showed how curcumin activates the specific protein that can slow or
stop the growth of mesothelioma cells. Professor of medicine at Case Western
Reserve University and lead researcher of the study, Afshin Dowlati, M.D.,
told Asbestos.com the study "is very significant." Although the study wasn't
performed on humans, Dowlati said curcumin "has shown clearly that it can
reduce the cancer growth."
COX-2 inhibitors, conventional and natural,
including curcumin
MyDigitalFC.com
July 2015
Curcumin, the herbal aspirin, has been shown to inhibit
certain growth factors. Every tumour needs blood supply and curcumin seems
to impede them. Research suggests that curcumin ‘reawakens’ a key
tumour-suppressor gene. It also inhibits metastases, especially in prostate
and breast cancer, and quells other cancer cells, besides preventing the
re-growth of cancer stem cells which populate the core of several tumours.
New research hails curcumin as a ‘holistic’ anti-cancer herb, because of its
success in not only halting cancer formation, replication and spread, but
also providing the synergy to other anti-cancer drugs, while protecting
healthy cells and organs. Research in the UK evidences that curcumin and
chokeberry, for instance, can work together to induce cancer cell death
(apoptosis) and prevent the spread of malignant cancer cells. Studies also
suggest that curcumin can prevent cancer stem cells from re-growing the
tumour. Recent research has shown curcumin can dexterously counter the
dangerous effects of hormone replacement therapy (HRT) and its hazardous
relationship with breast cancer. According to clinicians women could take
curcumin supplements to protect themselves from developing
progestin-accelerated tumours, primarily because synthetic progestin
increases vascular endothelial growth factor (VEGF), a protein that helps
form the blood supply to developing tumours. Curcumin inhibits VEGF and,
thus, reduces the potential of breast cancer to proliferate.
Formation of Neural Tube Defects Reduced by
Curcumin
EndocrinologyAdvisor.com
July 2015
Curcumin appears to reduce high glucose-induced neural
tube defect (NTD) formation by blocking cellular stress and activation of
caspases, according to an experimental study published in the June 4 issue
of the American Journal of Obstetrics & Gynecology... Under high-glucose
conditions, curcumin suppressed oxidative stress in embryos. Treatment
correlated with reductions in the levels of the lipid peroxidation marker,
4-hydroxynonenal, nitrotyrosine-modified protein, and lipid peroxides. In
addition, curcumin blocked endoplasmic reticulum stress and abolished
caspase 3 and 8 cleavage in embryos cultured under high-glucose conditions.
Curcumin ameliorates high glucose-induced neural
tube defects by suppressing cellular stress and apoptosis
Am J Obstet Gynecol July 2015
Curcumin
reduces high glucose-induced NTD formation by blocking cellular stress and
caspase activation, suggesting that curcumin supplements could reduce the
negative effects of diabetes on the embryo. Further investigation will be
needed to determine if the experimental findings can translate into clinical
settings.
5 supplements every man should take
Personal Liberty Digest
July 2015 Curcumin has been
studied as a potential cancer-fighting agent and has
demonstrated an ability to reduce prostate cancer tumors. The
authors of a new study in Tumour Biology, for example, reported
on a mechanism by which curcumin inhibits the growth of prostate
cancer cells. Curcumin also helps support prostate health in men
who have prostatitis and benign prostatic hyperplasia. In
addition, the compound is a potent antioxidant valued for its
ability to reduce inflammation and pain in conditions such as
osteoarthritis, as well as act as a blood thinner and
immune-system booster. Curcumin has shown anti-diabetic effects
and reduced diabetic complications.
Curcumin inhibits growth of prostate
carcinoma
Tumour Biology July
2015
Prostate cancer
(PC) is a prevalent cancer in aged men. Curcumin is an active ingredient
that has been extracted from the rhizome of the plant Curcuma longa.
Recently, a potential of Curcumin against PC has been reported in PC
West discovers health benefits of Indian spice turmeric
Press of Atlantic City July 2015 A
recent review published in the journal Molecules said studies to
date "suggest that chronic inflammation, oxidative stress and
most chronic diseases are closely linked, and that antioxidant
properties of curcumin can play a key role in the prevention and
treatment of chronic inflammation diseases." An M.D. Anderson
Cancer Center review of curcumin research, in the journal
Phytotherapy Research in 2014, found that it regulates
inflammation that "plays a major role in most chronic illnesses,
including neurodegenerative, cardiovascular, pulmonary,
metabolic, autoimmune and neoplastic diseases." Another M.D.
Anderson study found that curcumin exhibits "antioxidant,
anti-inflammatory, antiviral, antibacterial, antifungal, and
anticancer activities," all bolstering its "potential against
various malignant diseases, diabetes, allergies, arthritis,
Alzheimer's disease and other chronic illnesses.
6 foods that help fight cancer
Cosmopolitan February 2015
This popular curry spice contains an active
compound called curcumin (it's what gives turmeric its bright yellow-orange
colour) which has been shown to display powerful anti-cancer activity. In
fact, curcumin has the most evidence-based literature supporting its use
against cancer of any nutrient. Professor Bharat Aggarwal, from the MD
Anderson Cancer Center in Texas goes as far as saying, "No cancer has been
found, to my knowledge, which is not affected by curcumin." Pretty powerful
stuff then!
Turmenic Can Erase Bad Memories And Fight Mental
Disorders
Wall Street OTC February 2015
The research stated
that an ingredient found in turmenic, called curcumin is involved in the
process of both helping the printing of the new fears a person is dealing
with and also at erasing existent negative memories. This new discovery,
might come in the help of researchers for developing treatments for people
suffering from mental disorders.
Turmeric: The New Superfood
Inquisitr.com February 2015
Curcumin (not related to cumin) is an
antioxidant and the active ingredient in turmeric. Although it is
continuously being studied, curcumin has been shown to inhibit several types
of cancer cells. According to the American Cancer Society, turmeric is
mostly used as an anti-inflammatory herbal remedy, with fewer side effects
than common pain relievers.
Top Herbs, Latest Research
naturalproductsinsider.com February 2015
Curcumin has sparked a variety
of scientific exploration into new areas, as research has recently indicated
the compound can boost levels of the omega-3 docosahexaenoic acid (DHA) in
the brain, where it can positively affect cognitive health. Also, drug
discovery scientists have focused on novel analogs of curcumin in an effort
to find compounds that have similar health benefits and overcome some of the
absorption and stability challenges with the herb.
Turmeric Beneficial for
Brain Health
Newswire.net
February 2015 A recent study showed that curcumin encourages the immune
system to send macrophages to the brain. A clinical trial was performed that
involved people with severe cognitive decline to test the effects of
curcumin. The results showed that participants taking curcumin had
significantly higher levels of dissolved abnormal proteins in their blood
compared to those in the placebo group. This study showed that curcumin has
the ability to effectively pass into the brain, bind to beta-amyloid plaques
and assist the body in their breakdown. Curcumin is one of the only
substances known to have such a profound protective effect on the brain.
Curcumin: This compound
in turmeric can boost your heart health
TheStar.com February 2015
Adding spice – in the form of curcumin
supplements – to the daily diets of people with risk factors for heart
disease may lower inflammation, a new study suggests.
Effect of curcuminoids
on oxidative stress: A systematic review and meta-analysis of randomized
controlled trials
Sciencedirect.com February 2015
This meta-analysis showed a significant
effect of curcuminoids in elevating serum SOD and catalase activities, GSH
concentrations, and reduction of serum lipid peroxides.
Effect of curcumin supplementation on
physiological fatigue and physical performance in mice
Nutrients. February 2015
Curcumin is a well-known phytocompound and food
component found in the spice turmeric and has multifunctional
bioactivities....Curcumin supplementation may have a wide spectrum of
bioactivities for promoting health, improving exercise performance and
preventing fatigue.
Turmeric
Beneficial for Brain Health
NewsWire.net, February 2015
A recent study showed that curcumin encourages the immune system to send
macrophages to the brain. A clinical trial was performed that involved people
with severe cognitive decline to test the effects of curcumin. The results
showed that participants taking curcumin had significantly higher levels of
dissolved abnormal proteins in their blood compared to those in the placebo
group. This study showed that curcumin has the ability to effectively pass into
the brain, bind to beta-amyloid plaques and assist the body in their breakdown.
Curcumin is one of the only substances known to have such a profound protective
effect on the brain
Curry spice
linked to improved memory
The Guardian, February 2015
Curcumin, a bright-yellow compound found in the root of the Indian spice
turmeric, prevented new fear memories being stored in the brain, and also
removed pre-existing fear memories, researchers found.
Curcumin
prevented new fear memories being stored in the brain and removed pre-existing
fear memories
Mail Online, February 2015
Curcumin is known to have an anti-inflammatory effect on the body, and this may
be how it works on fearful memories, said Professor Schafe.‘Inflammatory
processes have been implicated in a wide range of diseases ranging from
allergies to cardiovascular disease to Alzheimer’s,’ he said.‘Inflammation has
also been implicated in psychological disorders such as depression, anxiety and
post-traumatic stress disorder.‘Some of these same inflammatory pathways have
also been implicated in memory formation, so it all fits.
Curcumin's
ability to fight Alzheimer's studied
Science Daily, January 2015
Curcumin, a natural product found in the spice turmeric, has been used by many
Asian cultures for centuries, and a new study indicates a close chemical analog
of curcumin has properties that may make it useful as a treatment for the brain
disease. “Curcumin has demonstrated ability to enter the brain, bind and destroy
the beta-amyloid plaques present in Alzheimer’s with reduced toxicity,” said
Wellington Pham, Ph.D., assistant professor of Radiology and Radiological
Sciences and Biomedical Engineering at Vanderbilt and senior author of the
study, published recently in the Journal of Alzheimer’s Disease.
The Spice
Ingredient That Can Block Bad Memories
Time Magazine, January 2015
Curcumin, a compound found in turmeric that may have protective effects against
neurodegenerative diseases, might one day help those with PTSD let go of bad
memories, suggests a new rat study published in the journal
Neuropsychopharmacology.
Reduce Heart
Disease with Turmeric – It’s Just as Effective as Exercise and
Cholesterol-Reducing Drug
The Raw Food World, January 2015
One study found that curcumin contains anti-thrombotic, anti-proliferative, and
anti-inflammatory effects and can decrease the serum cholesterol level and
protect against atherosclerosis. Several studies show the major benefit of
curcumin for heart disease is improving the endothelium function in the lining
of the blood vessels. Endothelium dysfunction is the main cause of heart disease
and causes the endothelium to inefficiently regulate blood pressure, blood
clotting, and other factors. Not only did curcumin help endothelial function,
but also one study found that it’s just as effective as exercise.In addition,
another study showed that it works just as well as the drug Atorvastatin. One
study showed that 121 patients who underwent coronary artery bypass surgery were
randomized to ingest either 4 grams of curcumin per day, a few days before and
after the surgery, or a placebo. The results show that the group who ingested
curcumin had a 65% decreased risk of experiencing heart attack whilst in the
hospital. The authors state, “The antioxidant and anti-inflammatory effects of
curcuminoids may account for their cardioprotective effects shown in this
study.”
Treat
Rheumatoid Arthritis with the Natural Healing Effects of Turmeric
The Raw Food World, January 2015
Curcumin is used to treat everything from skin and stomach ailments to
infections and inflammations. Other research shows curcumin helps reduce
Alzheimer’s. Now modern researchers have been intrigued enough to put turmeric’s
many historical benefits to the test – even rheumatoid arthritis.
Turmeric
associated with fewer neural tube defects in mice
2minutemedicine, January 2015
In the present work, authors investigate the impact of curcumin, a substance
found in the turmeric plant, on NTDs and markers of oxidative stress in mouse
embryos cultured in normal and high glucose environments. They found that
embryos cultured in high glucose environments and treated with 20μM curcumin
were less likely to experience oxidative stress and develop NTDs.
Curcumin in
turmeric fights BP, diabetes: Study
Times of India, January 2015
The health benefits of turmeric are due to the presence of a yellow compound
named curcumin. This compound is especially beneficial for fighting high blood
pressure. Remarkably, this compound is not only helpful in regulating blood
pressure but also effective in treating several late complications of diabetes
like affecting eyes, blood vessels, kidney and brain.
A Common
Kitchen Item Could Cure All Your Fears And Bad Memories
Carbonated.tv January 2015
Curcumin (a compound found in turmeric) has been found to possess the power to
impair newly acquired and reactivated fear memories. The spice is vastly
acknowledged for its medicinal properties, and contains anti-inflammatory bodies
which are known to help with arthritis and stomach issues, among many other
ailments.
Natural
Interventions to Keep Your Eyesight Sharp as You Age
The Raw Food World, January 2015
Curcumin, found in turmeric, contains a high amount of therapeutic
polyphenol and is the reason for its golden color. Turns out that curcumin is
able to protect against cataracts forming. (2) One study shows that curcumin had
the potential to function as an anticataractogenic agent, which could possibly
prevent the accumulation of calcium in the eye lens. (6) Another study showed
the antioxidant effects of curcumin that appears to prevent oxidative damage and
delay cataracts.
Curcumin and
major depression: A randomised, double-blind, placebo-controlled trial
Neuropsychopharmacology. December 2014
Curcumin supplementation influences several biomarkers that may be associated
with its antidepressant mechanisms of action. Plasma concentrations of leptin
and endothelin-1 seem to have particular relevance to treatment outcome.
Curcumin
inhibits proliferation of gastric cancer cells
World Journal of Surgical Oncology December 2014
Curcumin incubation significantly induced loss of MMP in SGC-7901 cells in a
dose- dependent manner (P <0.05); the cell apoptotic rate also dramatically
increased after curcumin incubation in a dose-dependent manner (P <0.05).
Curcumin
inhibit leptin gene expression and secretion in breast cancer cells
Cancer Cell International December 2014
Curcumin inhibits the expression and secretion of leptin and it could probably
be used as a drug candidate for the breast cancer therapy through the leptin
targeting in the future.
Curcumin,
curry are spice superstars
Harold-Review.com December 2014
More than 900 published research papers pertaining to curcumin’s anticancer
activity. One of these papers found that curcumin has the ability to make some
cancer cells commit suicide.
Curcumin
restores mitochondrial functions and decreases lipid peroxidation in liver and
kidneys of diabetic db/db mice
Biological Research December 2014
Hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases
TBARS levels in mitochondria from the liver and kidneys of diabetic mice,
whereas curcumin may have a protective role against these alterations.
Curcumin and
tackling mesothelioma
News Medical December 2014
As previous researchers had already demonstrated that curcumin can increase
PIAS3, we used curcumin to increase the PIAS3 levels in mesothelioma cancer
cells. When we exposed these cells to low levels of curcumin, we saw an increase
in the intracellular levels of PIAS3. Furthermore, when we increased PIAS3, the
activation of STAT3 decreased, and, in turn, the cancer cells started growing
much more slowly or stopped growing altogether. So, curcumin affects
mesothelioma cells by increasing the intracellular PIAS3 and therefore
decreasing the STAT3 activation and cancer cell growth.
Five
Benefits You Need To Know About The Ingredient That Helps Make Curry
YouthHealingMag.com December 2014
The active ingredient in turmeric is curcumin, which is known as a powerful
antioxidant. This means it targets dangerous free radicals in the body and
reduces the damage they are able to cause DNA and cells.A study in the Sept 2014
issue of Life Sciences performed an extensive review on curcumin and
wound/injury healing. Researchers found turmeric (curcumin) to have beneficial
properties that appear to speed the wound healing process. These modes of action
include the modulation of inflammation and oxidation, the ability to improve
granulation tissue formation, tissue remodeling, and deposition of collagen.
Curcumin may be able to prevent the oxidation of cholesterol in the body. Since
oxidized cholesterol is what damages blood vessels and builds up in the plaques
that can lead to heart attack or stroke, preventing the oxidation of new
cholesterol may help to reduce the progression of atherosclerosis and diabetic
heart disease.
Unique
Health Benefits Of Turmeric
Lifehacker November 2014
Curcumin, contained in turmeric, gives it powerful anti-oxidant properties,
making it a strong agent against cancer. Experts say that turmeric is naturally
anti-inflammatory, and while it's not a one-stop cure against the disease, it
does inhibit neoplastic growth by preventing the formation of tumor blood
vessels. About 30 studies exist that suggest curcumin has anti-tumor effect.
Oral
curcumin shown effective in psoriasis
Skin & Allergy News Digital Network November 2014
Studies have shown that curcumin has antiproliferative, antiangiogenic, and
anti-inflammatory effects. In a small study by other investigators, topical
turmeric not only successfully cleared psoriasis lesions, it also suppressed
phosphorylase kinase activity, which is important to keratinocyte proliferation
How Curry
Can Kill Cancer Cells
Care2.com October 2014
In cancer cells, curcumin, the pigment in the spice turmeric that makes curry
powder yellow, upregulates and activates death receptors (as shown in human
kidney cancer cells, skin cancer cells, and nose and throat cancer cells).
Curcumin can also activate the death machine directly (as shown in lung cancer
and colon cancer). Caspases are so-called “executioner enzymes,” that when
activated, destroy the cancer cell from within by chopping up proteins left and
right—kind of like death by a thousand cuts. And that’s just one pathway.
Curcumin can also affect apoptosis in a myriad other ways, affecting a multitude
of different types of cancer cells. It also tends to leave normal cells alone
for reasons that are not fully understood. Overall, researchers “showed that
curcumin can kill a wide variety of tumor cell types through diverse mechanisms.
And because curcumin can affect numerous mechanisms of cell death at the same
time, it’s possible that cancer cells may not easily develop resistance to
curcumin-induced cell death like they do to most chemotherapy.”
Turmeric
extract can have the potential to boost brain stem cells
TheRawFoodWorld,com October 2014
Curcumin is one of the ingredients in turmeric that exhibits over 150
potentially therapeutic activities and researchers have found it to play a
significant role in improving Parkinson’s, Alzheimer’s, and stroke damage...Dr.
William LaValley is one of the leading natural medicine cancer physicians. He
actually devoted his time in researching the science of curcumin, which has the
most evidence-based literature supporting its use against cancer of any other
nutrient. He explained, “The curcumin molecule may cause either an increase in
activity of a particular molecular target, or a decrease/inhibition of activity.
Either way, studies repeatedly show that the end result is a potent anti-cancer
activity.”
Wonder Herb
MyDigitalFC.com October 2014
Curcumin is the colouring principle of turmeric — it is the element that gives
the herb its yellow hue. Aside from being the most important component of
turmeric, curcumin is responsible for the herb’s anti-inflammatory effects.
Research suggests that curcumin, like cayenne, another medicinal spice found in
chillies, depletes substance P, the pain receptor and neurotransmitter, in the
nerve endings (nociceptors). Research also suggests that curcumin and related
compounds suppress pain through a mechanism similar to conventional coxib-2
inhibitors — the ‘new’ class of non-steroidal anti-inflammatory drugs (NSAIDs)...Laboratory
and animal studies suggest that curcumin has the potential to prevent and treat
various forms of cancer: colon, prostate, breast, and skin. As a matter of fact,
there has been a substantial amount of research on turmeric’s anti-cancer
potential and the results are promising. In one clinical study, researchers
examined the pain-relieving properties of curcumin and/or whether it could
suppress coxib-2 expression in human colon cancer cells. After exposing colon
cancer cells to curcumin, they found the compound not only subdued cell growth,
but also downgraded the expression of coxib-2 on the basis of a time- and
dose-formatted chart. In addition, researchers observed that curcumin appeared
to be a safe, natural coxib-2 inhibitor in human patients.
Carcinogen
Blocking Effects of Turmeric
Care2.com October 2014
Curcumin, present in the Indian spice turmeric, which is used in curry
powder, is one such agent that is currently under clinical investigation for
cancer chemoprevention.” According to their mode of action, chemopreventive
agents are classified into different subgroups: antiproliferatives,
antioxidants, or carcinogen-blockers. Curcumin belongs to all three, given its
multiple mechanisms of action. Curcumin appears to play a role helping to block
every stage of cancer transformation, proliferation, and invasion, and may even
help before carcinogens even get to our cells. A study back in 1987 investigated
the effects of curcumin on the mutagenicity (DNA mutating ability) of several
toxins and found that curcumin was an effective antimutagen against several
environmental and standard mutagenic and cancer-causing substance.
Curcumin
inhibits breast cancer stem cell migration.
Stem Cell Research Therapy October 2014
Curcumin, a plant ployphenol, has several anti-tumor effects and has been shown
to target CSCs. Here, we aimed at evaluating (i) the mechanisms underlying the
aggravated migration potential of breast CSCs (bCSCs), and (ii) the effects of
curcumin in modulating the same...Cumulatively, our findings disclose that
curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative
feedback loop.
Health
Benefits Of Turmeric
Huffingtonpost.com October 2014
Curcumin, the compound in turmeric responsible for that bright hue, is behind a
whole host of the health benefits attributed to the spice. A 2012 study examined
one perk of curcumin in particular: the ability of the extract to prevent heart
attacks among bypass patients. The study followed 121 patients who had bypass
surgery between 2009 and 2011. Three days before surgery through five days
after, half of the patients took curcumin capsules, while the other half took
placebo pills. During their post-bypass hospital stays, more people in the
placebo group experienced a heart attack (30 percent) compared with those in the
curcumin group (13 percent), Reuters reported. While not a substitute for
medication, the researchers pointed out, the antioxidant and anti-inflammatory
properties of curcumin may contribute to as much as a 65 percent lower chance of
heart attack among bypass patients. ... Among people with prediabetes, curcumin
capsules were found to delay the onset of Type 2 diabetes in a 2012 study. Over
nine months, study participants were given either curcumin supplements or
placebo capsules. Just over 16 percent of people taking the placebo pill were
diagnosed with Type 2 diabetes by the end of the study, while no one taking
curcumin was. Again, researchers chalk these results up to the anti-inflammatory
and antioxidant powers of the compound. ... While studies in humans are still in
very early stages, lab and animal studies have shown promising effects of
curcumin in the fight against cancer. Curcumin "interferes with several
important molecular pathways involved in cancer development, growth and spread,"
according to the American Cancer Society, even killing cancer cells in the lab
setting and shrinking tumors and boosting the effects of chemotherapy in
animals.
Turmeric
enhances mood in depression research trial
Medicalxpress.com October 2014
Curcumin was significantly more effective than the placebo in improving several
mood-related symptoms in the volunteers. The compound had an even greater
efficacy in a small subgroup of individuals with atypical depression, which can
be characterised by significant weight gain or increased appetite and
hypersomnia. "In animal-based studies curcumin has been consistently shown to
have antidepressant effects and it has been hypothesised that curcumin would
have antidepressant effects in people with major depression," said Dr Lopresti,
who is a clinical psychologist in a private practice. "There have been a few
positive human-based studies investigating the effects of curcumin in
depression. However, this is the first randomised, double blind,
placebo-controlled study and over the longest duration.
Shows
Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism
Yumanewsnow.com October 2014
The researchers treated human colon cancer tumor cells with curcumin. "We
discovered that curcumin turns off the active form of cortactin," said
Radhakrishnan, who led the experiments in the lab. "Thus, when cortactin is
turned off, cancer cells lose the ability to move and can't metastasize to other
parts of the body." More specifically, curcumin "turned off" cortactin by
interacting with, and activating, an enzyme known as PTPN1. This enzyme acts as
a phosphatase to remove phosphate groups from cortactin – a process known as "dephosphorylation."
"This effect, essentially known as 'dephosphorylating cortactin' correlated with
reduced ability of colon cancer cells to migrate," Kiela said. "This suggests
that curcumin reduces cancer cells' ability to migrate, meaning the cancer can't
metastasize."
Curcumin
restores sensitivity to retinoic acid in triple negative breast cancer cells
Biomedcentral.com October 2014
Curcumin suppresses the expression level of FABP5 and PPARβ/δ in triple
negative mammary carcinoma cells. By targeting the FABP5/PPARβ/δ pathway,
curcumin prevents the delivery of retinoic acid to PPARβ/δ and suppresses
retinoic acid-induced PPARβ/δ target gene, VEGF-A. Our data demonstrates that
suppression of the FABP5/ PPARβ/δ pathway by curcumin sensitizes retinoic acid
resistant triple negative breast cancer cells to retinoic acid mediated growth
suppression.
Reverse
Alzheimer’s, Parkinson’s and Rheumatoid Arthritis with ashwaganda, curcumin and
Vitamin D
Therawfoodworld.com October 2014
It appears that ashwaganda, curcumin, Vitamin D and exercise may help the body
remove amyloid protein, which is thought to cause diseases such as Alzheimer’s,
Parkinson’s Disease, Rheumatoid Arthritis and several other amyloid diseases.
Oral
curcumin may protect gut function
Healthcanal.com October 2014
Oral curcumin may be a viable therapy to improve intestinal barrier function
changes caused by consuming a high-fat Western diet, according to a preclinical
study by Virginia Commonwealth University School of Medicine researchers.
Curcumin
inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA
induced macrophages
Journal of Translational Medicine October 2014
Curcumin exerts well-known anti-inflammatory and antioxidant effects and
probably has a protective role in the atherosclerosis.
Curcumin
fights Alzheimer's disease
Foodconsumer.org October 2014
A study led by scientists at Beijing University of Chinese Medicine in Beijing,
China suggests taking curcumin supplements may help prevent Alzheimer’s
disease...Curcumin is an important supplement that may be used to prevent or
treat cancer, inflammatory diseases, cystic fibrosis, and diabetes mellitus and
many other diseases in addition to Alzheimer's disease.
Colon cancer
metastasis blocked by curcumin
Oncologynurseadvisor.com October 2014
Curcumin, derived from the spice turmeric,
blocks the protein cortactin in colon cancer.
Study
promotes turmeric as promising anti-cancer agent
GroundReport.com October 2014
Curcumin could provide an alternate means to the prevention of cancer. The
effect of curcumin as an antioxidant, antibacterial agent and anti-tumor agent
are well documented and it also has a therapeutic or preventive effect on
several other diseases. The study looks at the chemopreventive effects of
curcumin in cancer-prevention with specific focus on curcumin’s effect on the
regulation of cell signaling and genetic pathways. Further, the study notes that
turmeric and curcumin show no significant toxicity at all.
Healthy
Living with Ruth Holmes: Ancient herb used as treatment
Stroud News and Journal September 2014
The bright yellow pigment contains the active compound curcumin, which is found
in the roots of certain tropical plants like turmeric, and has powerful
anti-inflammatory actions. Just like the non steroidal anti inflammatory
medications, it blocks the formation of the pro-inflammatory prostaglandins, and
leukotrienes (also inflammatory) but does not have the side effects on the
stomach that the anti-inflammatory would. as an anti-inflammatory effect on the
stomach. Curcumin is highly recommended in osteoarthritis and rheumatoid
arthritis as well as post operative inflammation. Curcumin can also be used as
a poultice for inflammatory skin conditions like psoriasis and eczema, this herb
will not treat any pain, as its action is to reduce and prevent further
inflammation from occurring which is what causes the discomfort in the first
place.
Mesothelioma Patients May Benefit from Common
Spice
MesotheliomaLawyerCenter.org September 2014
A new
study on combating mesothelioma suggests that the component curcumin, found
in the popular turmeric spice, may help fight mesothelioma by increasing
protein inhibitors that can slow down the cancer. Conducted by experts and
doctors at Ohio’s Case Comprehensive Care Center and Germany’s
Georg-Speyer-Haus Institute for Biomedical Research, the study focused on a
protein known as STAT3, which is known to trigger and promote the growth of
cancers. When victims have a lower level a PIAS3, an enzyme that fights
STAT3, they have an increased chance of dying from mesothelioma. However,
when curcumin was administered to patients, their PIAS3 increased, thus
fighting off the protein that increases cancer.
Get your
glow from kitchen
Wonderwoman.intoday.in September
2014 Curcumin: An antioxidant derived from the turmeric root, its active ingredient
can help calm swelling and reduce wrinkles and other signs of ageing.
Curcumin
could slow down progression of lung lining cancer
Thehealthsite.com September 2014
Curcumin show promise in slowing the progression of mesothelioma, a cancer of
the lung’s lining often linked to asbestos
Curcumin,
The Asian Spice, Helps Fight Mesothelioma
Medicaldaily.com September 2014
Curcumin, has long been known for its cancer-inhibiting properties. But when
it's combined with cancer-destroying peptides (bonded chains of amino acids),
the resulting molecule promotes growth of a protein inhibitor known to combat
the progression of mesothelioma.
Component in
Spice May Help Slow Mesothelioma Growth
Survivingmesothelioma.com September 2014
Yet another study has demonstrated the potential mesothelioma-fighting
properties of curcumin, an anti-inflammatory polyphenol that is the primary
component in the spice turmeric. The latest study suggests that applying
curcumin along with cancer-fighting peptides may increase the levels of a
protein inhibitor that can slow the progression of mesothelioma.
October 2014
Curcumin
restores sensitivity to retinoic acid in triple negative breast cancer cells
BMC Cancer September 2014
Treatment of retinoic acid resistant triple negative breast cancer cells with
curcumin sensitized these cells to retinoic acid mediated growth suppression, as
well as suppressed incorporation of BrdU. Further studies demonstrated that
curcumin showed a marked reduction in the expression level of FABP5 and PPARbeta/delta.
We provide evidence that curcumin suppresses p65, a transcription factor known
to regulate FABP5.
Curcumin
boosts testosterone level
ergo-log.com August 2014
Curcumin might be used as an alternative drug for the treatment of male
infertility problems.
The new
blockbuster nutrient?
Theage.com.au August 2014
Turmeric, with its active ingredient curcumin,
are "blockbuster nutrients", according to professor Marc Cohen, head of
Complementary Medicines at RMIT. "Turmeric is a powerful antioxidant which stops
lipid oxidation and is anti-inflammatory," says Cohen, who devoted an entire
chapter to turmeric in his book, Herbs and Natural Supplements: An
Evidence-Based Guide. "It is a possible aid in preventing chronic
degenerative diseases like Alzheimer's disease."
Curcumin for
the treatment of major depression: a randomised, double-blind, placebo
controlled study
Newindianexpress.com August 2014
Curcumin, the principal curcuminoid derived from turmeric influences several
biological mechanisms associated with major depression, namely those associated
with monoaminergic activity, immune-inflammatory and oxidative and nitrosative
stress pathways, hypothalamus-pituitary-adrenal axis activity and
neuroprogression, the study said. It is effective for the treatment of
depressive symptoms in individuals with major depressive disorder. Curcumin is
the substance in turmeric which gives the yellow color.
Eat to Beat
Cancer
aarp.org August 2014
Laboratory studies have found that curcumin—the main ingredient in the spice
turmeric, which gives curry its characteristic yellow color and sizzle—can fight
against cancerous changes in healthy cells as well as slow the growth of
malignant cells. Some evidence suggests that curcumin may also offer protection
against brain tumors.
Powdered
Gold
Cltampa.com August 2014
With more than 50 healing properties, modern research has found that the
effectiveness of turmeric stems from curcumin, a natural compound it contains
that is rich in antioxidants and anti-inflammatory ability. Thousands of animal
and human studies have been conducted on turmeric and curcumin as both a
preventive and curative agent. Current research targets curcumin’s efficacy in
treating some of the world’s biggest health threats including cancer, heart
disease, type 2 diabetes and Alzheimer’s disease.A number of curcumin studies
have shown promising results. Curcumin can kill cancer cells in laboratory
dishes and also slows the growth of the surviving cells. Curcumin has been found
to reduce development of several forms of cancer in lab animals and to shrink
animal tumors. On the U.S. National Library of Medicine’s website,
2,840 abstracts are listed about the study and benefits of turmeric and
curcumin.
Mechanism of curcumin resistance to human cytomegalovirus in HELF cells
BMC Complementary and Alternative Medicine August 2014
Curcumin anti-HCMV effect may possibly be that curcumin concurrently alters
host cell microenviroment and inhibits the HCMV antigen expressions. These
findings may provide a basic understanding of the curcumin anti-HCMV effect
and a novel strategy for further development of curcumin anti-HCMV
treatment.
What's
the one cooking trick for weight loss success?
Nola.com July 2014
Turmeric, the yellow ground spice you find in curry power, is a superspice
when it comes to health and weight loss because of its active compound
called curcumin. Hundreds of studies have been completed on its
effectiveness against cancer, skin ailments, and lung health, just to name
of few. But when it comes to the battle of the bulge, turmeric extract
suppressed fat tissue growth in rodent models.
Turmeric branded latest superfood to protect against
Alzheimer's
Business-Standard.com July 2014
Since inflammation is a major
factor in the development of most chronic degenerative diseases including
cardiovascular disease, allergies, type 2 diabetes and Alzheimer's disease,
curcumin's anti-inflammatory power holds great promise in all of these
conditions and many more. Murray said that the antioxidant activity of
curcumin is superior to antioxidant nutrients like vitamin C and E, as they
are effective against only water and fat-soluble pro-oxidants. Curcumin also
helps in preventing LDL cholesterol - one of the worst kind of cholesterol -
from getting oxidised and damaging arteries. and evidence is gaining that
curcumin could also slow down ageing and prevent age-related diseases.
Healthiest Foods
palmbeachillustrated.com July 2014
Curcumin: An active ingredient in turmeric, this antioxidant has shown
anti-cancer effects in laboratory studies and is anti-inflammatory.
Turmeric, Curcumin fights Alzheimer's disease
Foodconsumer.org July 2014
Curcumin one of the active ingredients found in turmeric has been known to
protect against cancer, Alzheimer's disease, type 2 diabetes mellitus,
allergies, arthritis and other chronic diseases. Epidemiological studies
show that incidence of Alzheimer's disease in Southeast Asia where turmeric
is commonly consumed as a spice was 4.4 times lower, compared to that found
in countries where the price is not as commonly used.
Curcumin
modulation of high fat diet-induced atherosclerosis and steatohepatosis in
LDL receptor deficient mice
Sciencedirect.com July 2014
Curcumin also reduced body weight gain and body fat without affecting fat
distribution...However, at a high dose, curcumin suppressed development of
steatohepatosis, reduced fibrotic tissue, and preserved glycogen levels in
liver. Conclusion Curcumin through a series of complex mechanisms,
alleviated the adverse effects of high fat diet on weight gain, fatty liver
development, dyslipidemia, expression of inflammatory cytokines and
atherosclerosis in Ldlr−/− mouse model of human atherosclerosis.
5 spices
to keep in your medicine cabinet
FoxNews.com July 2014
Curcumin, the active compound in turmeric, is what makes this spice so
special and turmeric happens to be one of the only readily available, edible
forms of it. A 2007 study also showed curcumin to have anticancer
properties, with the potential to fight malignant diseases, diabetes,
allergies, arthritis and Alzheimer’s disease.
Evaluation of the Effect of Curcumin Capsules on Glyburide Therapy in
Patients with Type-2 Diabetes Mellitus
Phytotherapy Research July 2014
The co-administration of curcumin capsules with glyburide may be beneficial to
the patients in better glycaemic control. The lipid lowering and antidiabetic
properties of the curcumin show as a potential future drug molecule.
Antibiotic Properties Naturally Found in the Kitchen
Globalnews.com July 2014
Turmeric can boost immunity, helps to maintain cholesterol levels,
and can even slow the process of aging.
Research points to health benefits
of turmeric
Curcumin as an anti-cancer agent ... Clinical
trials with curcumin indicate safety,
tolerability, non-toxicity (even up to doses of 8,000 milligrams
per day), and efficacy."
Curcumin
regulates cell fate and metabolism by inhibiting hedgehog signaling in
hepatic stellate
We previously reported that
curcumin
has potent antifibrotic effects in vivo and in vitro, but the
underlying mechanisms are not fully elucidated.
Combination of
curcumin and bicalutamide enhanced the
growth inhibition of androgen
Combination of
curcumin
and bicalutamide enhanced the growth inhibition of
androgen-independent prostate cancer cells...
Research is confirming benefits of curcumin
Among its active ingredients is
curcumin,
which is being actively studied for its anti-inflammatory,
antioxidant, antimicrobial and cancer-fighting .
Study: Curcumin
May Help Fight Oral and Cervical Cancer
According to Mishra, the natural
antioxidant and the key ingredient of turmeric,
curcumin,
has the cancer-fighting properties. The research has claimed .
Study Finds Turmeric Can Help Treat Oral Cancers
An antioxidant present in turmeric,
called curcumin,
has proven effective for the treatment of the human
papillomavirus. (Simon A. Eugster/Wikipedia ..
Alternative Therapies to Prevent Diabetes
Curcumin,
the substance in turmeric spice that gives Indian curry its
distinctive yellow color, is an anti-inflammatory that bestows
many health benefits
The Arthritis Foundation Has Identified 9
Supplements for Arthritis Symptoms
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Turmeric and
curcumin
supplements are available, though some healthcare experts
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Turmeric Can Fight Oral And Cervical Cancer, Says
Study
According to a study published in the
journal E Cancer Medical Science, an antioxidant found in
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Circadian Responses to Chemo
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One of the herb's key active
ingredients - an antioxidant called
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Curcumin from
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Scientist have found that the
household curry spice curcumin,
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Try turmeric today
This is because it contains something
called curcumin,
which has multiple benefits. So with this in mind, we are taking
a look at just some of the ways ...
Turmeric a golden addition
It is thought that the
curcumin
properties found in turmeric are responsible for the
anti-inflammatory, anti-parasitic, anticancer and antiseptic
abilities.
Curry spice to overcome aches and sore muscles
Doctors based at the Olympic Training
Centre, in Barcelona, Spain, have been testing a new formulation
of curcumin,
a member of the ginger family ...
MIND Protocol: Lifestyle Plan Beats Alzheimer's
"Alzheimer's is 70 percent less
common in India than in the U.S., likely because of the large
amounts of curcumin
that are used in curries and other ...
GRAEDONS' PHARMACY
A: There are more than 7,500
scientific publications on curcumin, but much of the
research for human health is still preliminary.
Curcumin
has been ...
The Spice That May Help Fight Breast Cancer
Exciting new research released in the
journal Clinical and Experiential Medicine found that
curcumin,
a naturally-occurring substance found in the ...
Dietary
curcumin may boost brain DHA: Study
Increased intake of
curcumin
could boost levels of docosahexaenoic acid (DHA) in the brain by
enhancing its conversion from other omega-3 ...
One of the Best Antibiotics Could Be in Your
Kitchen
Dozens of studies have revealed many clinical benefits
associated with curcumin. They include antioxidant properties,
anti-inflammatory activity and protection against chronic
diseases such as diabetes and cancer. The molecule also has
antimicrobial activity and is effective against bacteria,
viruses, and even fungi. For anyone looking for an antibiotic
alternative, this particular chemical is a potential golden
goose.
Curcumin
may be promising treatment for cancer
Curcumin,
a compound found in turmeric, may be a promising treatment for a
variety of cancers and other inflammatory diseases, according to
an ...
The life in your spice – the health benefits of
flavor
Another star in the spice rack is
turmeric, which contains curcumin, a compound now being
studied for its potential to prevent cancer and Alzheimer's ...
Spice Proves Effective Against Cancer
A new study has found that
curcumin,
a chemical compound found in turmeric, is a safe and promising
treatment for most cancers and other ...
Curcumin
proved effective at combating cancer
WA SCIENTISTS have helped re-affirm that
curcumin, a
chemical compound found in turmeric, is a safe and promising
treatment for most cancers and ...
Topical Application of Turmeric
Curcumin
for Cancer
In my video, Turmeric
Curcumin and Colon
Cancer, I talked about a study where researchers
showed that, by taking curcumin, the yellow
pigment in
The Spice that Stops
Muscle Pain in its Tracks
Exciting new research in the Journal of
the International Society for Sports
Medicine found that curcumin, one
of the active ingredients in the
spice ...
Turmeric
Curcumin and Colon Cancer
The low incidence of bowel cancer in
India is often attributed to natural antioxidants such as
curcumin,
the yellow pigment in the spice turmeric, used ...
The Spice that May Help Fight Breast Cancer
Both turmeric and
curcumin
supplements are readily available in most health food stores or
from your natural health professional.
4 Natural Supplements That Are as Powerful as
Drugs
Garlic and
curcumin
are two natural supplements that boost your immune health. ...
Curcumin
fights inflammation at the molecular level by blocking an ...
Turmeric May Reduce Brain Damage, Ease Memories
in Alzheimer's, PTSD
The substance, called
curcumin,
may be helpful in treating Alzheimer's disease and various
psychological conditions that stem from fearful memories.
These Are The Only 3 Supplements I'll Take
Curcumin:
About three years ago, I began to notice all the studies
reporting the broad, well-documented potential of
curcumin,
the active ingredient
Winter Depression
A study at Baylor University found
that curcumin,
the main compound in the spice turmeric, worked as well as the
popular antidepressant Prozac.
Aussie researchers trial turmeric for Alzheimer's
Sydney researchers are using brain
amyloid imaging to test the effects of
curcumin
– the active ingredient of the spice turmeric
Expert touts
disease-prevention benefits of Indian spices
FoxNews June 2014
Curcumin, derived from a plant that is native to the tropical southeastern
Indian state of Tamil Nadu, also is used "as an adjuvant in chemotherapy,
especially in breast, colon, head and neck cancer and in leukemia. Some
components of curcumin are clinically shown to prevent the formation of
prostate, skin and pancreas cancer cells and brain tumors.
Five Tips To Relieve Joint Pain
SMmirror.com June 2014
Curcumin, is a compound known to interfere with the chemicals that cause
inflammation. Multiple clinical studies have associated curcumin with
anti-inflammatory and antioxidant properties. In one study, two grams of
curcumin extract provided to subjects was found to provide pain relief that was
equivalent to ibuprofen for pain associated with osteoarthritis of the knee.
How What You Eat Can Help the Spinal Cord Heal Itself
Valpolife.com
June 2014 DHA and curcumin appear to invoke several molecular mechanisms that preserved
neurological function in the rats. This is an exciting first step toward
understanding the role that diet plays in protecting the body from degenerative
disease.
Why is there Turmeric in my cereal?
BangorDailyNews.com June 2014
Curcumin is actually an antioxidant that has been shown to inhibit cancer cells
in the laboratory, and curcumin slows the growth and spread of some cancers in
some animal studies. Clinical trials are underway to see how it will benefit
humans. Curcumin is being studied for its possible benefit for arthritis,
Alzheimer’s disease and stomach ulcers as well as lowering bad cholesterol.
Greenfudge.org May
2014 Curcumin has the ability to modulate genetic activity and expression—both by
destroying cancer cells and by promoting healthy cell function. It also promotes
anti-angiogenesis, meaning it helps prevent the development of additional blood
supply necessary for cancer cell growth. As for its effect on molecular
pathways, curcumin can affect more than 100 of them, once it gets into the cell.
Boost Immunity
IrishNews.com May 2014
Curcumin, the active ingredient in turmeric. This has been found to have
anti-allergy properties, which inhibit the release of histamine. Commonly used
in Middle Eastern and Asian cuisine as the spice turmeric, curcumin is a
phytochemical with powerful antioxidant and anti-inflammatory actions that are
comparable to steroidal and nonsteroidal drugs.
Protective effect of curcumin against heavy metals-induced liver damage
Sciencedirect.com
May 2014 Curcumin protects against the hepatotoxicity induced by heavy metals. • Curcumin
scavenges free radicals induced by heavy metals in liver. • Curcumin’s
hepatoprotective effect involves the heavy metals chelation. • Curcumin promotes
liver protection by upregulating the Nrf2/Keap1/ARE pathway. • Curcumin
analogues or formulations improve hepatoprotection against heavy metals.
Uncovering
Hidden Secrets of an Ancient Spice
Huffingtonpost.com May 2014
Curcumin could provide antidepressant effects. Research on turmeric and diabetes
also looks promising. Scientists have demonstrated that turmeric in the diet may
be helpful in decreasing blood sugar. Traditional health uses of turmeric in
India are to help wound healing and gastrointestinal symptoms. Now researchers
from The University of Nottingham and Ludwig Maximilians University in Munich
have found that curcumin may help reduce inflammation associated with tendinitis.
Both turmeric and curcumin have shown potential to prevent DNA damage and help
DNA repair. That is good news for preventing disease and slowing the aging
process.
Turmeric may reverse age associated cerebrovascular
dysfunction
examiner.com April 2014
Curcumin is an antioxidant present in high
amounts in turmeric which is the active ingredient that appears to provide
turmeric with a number of potential healing abilities. A new study which has
been published in the journal Cellular Physiology and Biochemistry has indicated
that turmeric might provide therapeutic benefits for reversing age-related
cerebrovascular dysfunction. In cerebrovascular dysfunction blood flow and
circulation to the brain is impacted.
Turmeric can
inhibit cancer causing cells
TheHindu.com April 2014
The active ingredient in turmeric is curcumin and since second millennium BC, it
is widely used in Asian medicine, food and cosmetics. In fact, medicinal uses of
turmeric are well documented in folk medicine, Ayurveda and traditional Chinese
and oriental medicine. It’s a fact that curcumin is therapeutic and helps in
treating respiratory conditions like asthma, liver disorders, anorexia, diabetic
wounds etc. It is anti-septic, anti-oxidant and anti-carcinogenic and that’s why
there is a lot of interest on turmeric.Research has proved that due to curcumin
there is low incidence of colon cancer and neuro-degenerative disorders such as
Parkinson’s in Asians. Research has proved that curcumin can inhibit cancer
causing cells or genes. The challenge now lies in delivering the right amount of
curcumin to the cancer cells.
Curcumin attenuates acute inflammatory injury
Journal of Neuroinflammation April 2014
curcumin administration may improve patient outcome by reducing acute activation
of microglia/macrophages and neuronal apoptosis.
Boost your health one cup at a time
TampaBay.com April 2014
Today, turmeric/curcumin research is focused on its effectiveness in fighting
cancer cell growth. Breast cancer research using stem cells has shown that
curcumin inhibits malignant cell formation. A study in the Asia Journal of
Clinical Nutrition reported that turmeric/curcumin can protect the gallbladder
and promote bile flow during detoxification from drugs, pesticides and other
toxins. Curcumin and a cruciferous vegetable (cauliflower, broccoli, Brussels
sprouts) make an excellent combination for removal of mercury, lead and plastic
residue.
New research
reveals that turmeric may be beneficial in many health conditions, with its
magic ingredient, curcumin
Dawn.com April 2014
‘The Golden Wonder Herb’ is much more than that: It is a natural antiseptic and
antibacterial agent, useful in disinfecting cuts and burns. Is a natural liver
detoxifier. May prevent and slow the progression of Alzheimer’s disease by
removing amyloyd plaque build-up in the brain. Is a potent natural
anti-inflammatory that works as well as many anti-inflammatory drugs but without
the side effects; it is a natural treatment for arthritis and rheumatoid
arthritis. Is a natural painkiller and cox-2 inhibitor. May aid in fat
metabolism and help in weight management. Has long been used in Chinese medicine
as a treatment for depression. Speeds up wound healing and assists in
remodelling of damaged skin. May help in the treatment of psoriasis and other
inflammatory skin conditions.
Curcumin
Inhibits Prostate Cancer Bone Metastasis
Journal of Cancer Therapy April 2014
A number of studies have focused on the beneficial properties of Curcumin (diferuloyl
methane, used in South Asian cuisine and traditional medicine) such as the
chemoprevention of cancer. Recent studies have also indicated that this material
has significant benefits for the treatment of cancer and is currently undergoing
several clinical trials.
Ocala.com March 2014
Curcumin, one of the active compounds in turmeric spice, popular in Indian
cuisine. Many studies prove curcumin slows down the growth of different types of
cancer. Curcumin may be helpful for pancreatitis because it reduces inflammation
in the pancreas and reduces inflammatory pain-causing chemicals. Wonderful, but
you may need special IVs or supplements to get it to work.
CapeGazette.com March 2014
In animal studies, turmeric’s bright yellow pigment, curcumin, has been
effective in preventing tumor formation. Observational studies in populations
that consume large amounts of curry have strongly suggested that curcumin may
help prevent cancer in the lower intestine.
Paktribune.com March 2014
Curcumin, an active ingredient of turmeric, can fight colon cancer when used in
combination with a popular anti-inflammatory drug, say researchers...Curcumin
increases the anti-cancer and anti-inflammatory effects of Celecoxib while
reducing its dose, thus reducing its toxic side-effects, including the rate of
heart attack and stroke.
WonderWoman.in March 2014
"We studied the effects of curcumin on patients with major depressive disorder,"
says study author Ajay Goel, PhD, director of epigenetics and cancer prevention
at Baylor University Medical Center. "It's possible it may help alleviate
short-term mood issues, too." Curcumin inhibits the production of monoamine
oxidase, an enzyme that at high levels is linked to depression.
GuardianLV.com March 2014
Over a series of six months the study revealed the involvement of turmeric
extract, curcumin does stop the fatty deposits forming on the inner surfaces of
the arteries obstructing the blood flow...The trials results in curcumin being
used without any serious unwanted effects and revealed lasting benefits for
diabetes patients. Turmeric is well-known for its liver healing properties
Curcumin is the active ingredient that gives turmeric its orange-yellow color.
Along with related chemicals, it comprises the extraction of curcuminoid.
CharismaNews.com March 2014
“Turmeric contains curcumin, which can inhibit the growth of cancer cells,” she
says. “It reduces inflammation. It supports your immune system, it’s great for
your liver function, and, as you know, it’s used in Indian cooking.”
Ocala.com March 2014
Put curcumin, the active ingredient of the common spice, turmeric, at the top of
your list of Alzheimer's preventives. Seriously. Researchers have published
1,000 scientific studies on the antioxidant and anti-inflammatory properties of
curcumin. A recent Japanese study showed symptom improvement for those who
supplemented with turmeric capsules for one year. Two participants who had
severe cases were even able to recognize family members by the study's
conclusion. Back in 2008, researchers in India published a paper reviewing the
major research done on curcumin as a treatment for Alzheimer's. They noted that
curcumin apparently has the ability to help a component of the immune system
(macrophages) clear away amyloid plaques from the brain. They concluded, “…based
on the main findings above, curcumin will lead to a promising treatment for
Alzheimer's.”
NewsTrackIndia.com March 2014
Curcumin, a spice used in the preparation of tumeric powder, reduced the size of
tumours in mice by a third while slowing the reproduction rate of rogue cells,
the Daily Express reported.
Natural
Products for Good Health
News.am February 2014
A study at Baylor University found that curcumin, the main compound in the spice
turmeric, worked as well as the popular antidepressant Prozac. Study
participants were divided into three groups: one took 500 milligrams of curcumin
twice a day; the second took a standard dose of Prozac, and the third group took
a combination of both. After six weeks, curcumin relieved symptoms of depression
as effectively as Prozac.
Atlantablackstar.com February 2014
Curcumin is a natural carotenoid and polyphenol which may be isolated from
Curcuma longa or turmeric, a rhizome. Owing to their structure, carotenoids are
scavengers of free radicals, which make them great anti-oxidants and boosters of
the immune system of vertebrates, humans included. Curcumin is also an effective
antibacterial agent and anti-carcinogenic. Studies have demonstrated that
curcumin inhibits the growth of a number of tumors when used in combination with
radiation therapy. In prostate cancer, curcumin overcomes the effect of
prosurvival gene expression induced by the exposure of cancer cells to
radiation.
WorldBulletin.com February 2014
The curcumin diet significantly reduced bile duct blockage and curbed liver cell
damage and scarring by interfering with chemical signalling pathways involved in
inflammation.
Cancer Prev Res (Phila).
February 2014 Curcumin, the primary component in the dietary spice turmeric, may be a powerful
ally in the
fight against malignant mesothelioma. The new study, published in the
journal Cancer Prevention Research, finds that curcumin may both attack existing
mesothelioma cells and protect against the development of new ones. Curcumin is
a polyphenol with anti-inflammatory properties. Numerous studies have confirmed
its ability to help fight cancer, including mesothelioma. In the newest study, a
team at the University of Vermont tested curcumin on
human mesothelioma cell lines as well as cells derived from infected mice.
TwoCircles.net January 2014
Curcumin has been shown to be particularly beneficial in this aspect. "These
phytochemicals showed their efficiency to counter DNA damage caused by arsenic.
This DNA damage initiates the process of cancer development; therefore reduction
of such damage may pave a way to cancer prevention. Apart from this,
phytochemicals also play a role in repair of DNA damage. We conducted a field
study where curcumin has been found to be of great value in combating the
problem with arsenic at the genetic level."
Huffington Post December 2013
Take advantage of curcumin (the substance that gives turmeric it's bright yellow
colour) because it can dramatically improve your health. The anti-inflammatory
and antioxidant powers of curcumin prevent and fight a wide variety of
conditions ranging from sleep deprivation to stress, and beyond.
The Financial Express January 2014
The benefits for heart health arise from curcumin, an active principle which is
anti-oxidant, anti-clotting, anti-inflammatory and anti-proliferative. Several
scientific studies have documented the effect of curcumin in decreasing blood
cholesterol levels. Anti-oxidant properties of curcumin may also help prevent
cardiovascular complications among diabetics.
BMC Complement Altern Med. 2013 Dec 24
The administration of curcumin to diabetic rats normalized significantly their
blood sugar level and TBARS values and increased the activities of all
antioxidant enzymes and reduced glutathione concentration.
FoodConsumer.org December 2013
Curcumin has bee known to prevent Alzheimer's
disease, diabetes mellitus, skin cancer, diabetic foot ulcers, triple
negative breast cancer, radiation dermatitis, fluoride-induced renal injury,
Parkinson's disease, colorectal cancer, and heart failure.
World Journal of Gastroenterology December 2013
Curcumin shows enhanced cytotoxicity toward
PTEN-deficient cancer cells, suggesting that it might be a potential
chemotherapeutic agent for cancers harboring PTEN mutations
Atlanta Blackstar, December 2013
Researchers found 26 percent fewer fatty artery deposits in the mice fed the
curcumin-enhanced diet. Fewer atherosclerotic lesions were seen in these mice.
In addition, the researchers found that curcumin seemed to actually change the
expression of genes related to plaque buildup in arteries...After 18 weeks, the
researchers found that just like lovastatin, curcumin lowered blood levels of
cholesterol, triglycerides and LDL cholesterol, while increasing levels of HDL
(“good”) cholesterol. It also led to changes in gene expression that could be
expected to reduce the risk of artery damage and heart disease.“Long-term
curcumin treatment lowers plasma and hepatic cholesterol and suppresses early
atherosclerotic lesions comparable to the protective effects of lovastatin,” the
researchers concluded. “The anti-atherogenic effect of curcumin is mediated via
multiple mechanisms including altered lipid, cholesterol and immune gene
expression.”
FoodConsumer.org December 2013
Curcumin has already been known to prevent obesity and diabetes mellitus in
animal studies and human trials...Curcumin was found to suppress oleic acid
induced lipid accumulation and lower triglycerides and total cholesterol
levels...."These results indicated that curcumin has the same ability to
activate AMPK and then reduce SREBP-1, and FAS expression, finally leading
to inhibit hepatic lipogenesis and hepatic antioxidative ability. In this
report, we found curcumin exerted a regulatory effect on lipid accumulation
by decreasing lipogenesis in hepatocyte. Therefore, curcumin extract may be
active in the prevention of fatty liver."
ioL Lifestyle December 2013
Previous research has shown curcumin acts on a compound called brain-derived
neurotrophic factor (BDNF), which helps in the development and functioning of
nerve cells.
Curcumin
obliterates colon cancer cells
NaturalNews.com December 2013
Cancer cell death was observed through curcumin’s ability to reduce
pro-caspase-3 levels, polymerase-1 cleavage and chromatin condensation. In a
time- and dosage-dependent manner, curcumin caused wild-type p53 HCT-116 cells
to self-destruct, while obliterating mutant p53 HT-29 cells in their tracks. The
researchers were so astounded that they proposed that curcumin may actually have
therapeutic potential in the management of colon cancer.
HeatlhNewsDigest.com
Curcumin is found in the
spice turmeric, the main spice used to prepare curry. Curcumin is thought to
have antioxidant properties, as it may decrease swelling and inflammation.
Preliminary research suggests that curcumin may prevent cancer and possibly slow
the spread of cancer.
Curcumin as
a regulator of epigenetic events.
HispanicBusiness.com December 2013
The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that
enters into the composition of curry, already described for its diverse and
broad biological activities, is nowadays well described as an inhibitor of DNA
methyltransferase so that it is considered as a DNA hypomethylating agent...This
dietary compound is able to restore the epigenetic regulation balance and
appears as an attractive preventive and/or therapeutic approach against human
cancer."
Turmeric spice could benefit those with Alzheimer’s disease
utSanDiego.com November 2013
Some research found that curcumin may help clear the amyloid plaques found in
Alzheimer's disease. Other studies documented curcumin as a powerful
anti-inflammatory that may have a role in the cure of Alzheimer’s. Some research
has found curcumin to be a robust antioxidant, which helps ease Alzheimer's
symptoms caused by oxidation and inflammation.
Foodconsumer.org November 2013
H.M. Maier from The Florida State University in Tallahassee, Florida, USA and
colleagues reviewed studies and found evidence from animal studies indicating
that curcumin, L-arginine and vitamin E as dietary supplements can help wound
healing in people with type 2 diabetes mellitus.
ProHealth.com October 2013
Turmeric is one the most thoroughly researched plants in existence today. Its
medicinal properties and components (primarily curcumin) have been the subject
of over 5600 peer-reviewed and published biomedical studies. In fact, our
five-year long research project on this sacred plant has revealed over 600
potential preventive and therapeutic applications, as well as 175 distinct
beneficial physiological effects.
FoxNews.com October 2013
The compound curcumin is found in turmeric, a spice commonly used in the Indian
curry. It’s packed with antioxidants, which help reduce inflammation and free
radicals in the body, and now it may help to ease depression symptoms as well.
Foodconsumer.org October 2013
Curcumin has been known to have protective effects against cancer and type 2
diabetes mellitus. It should not be a surprise that curcumin has antidiabetic
and anticancer bioactivities because it is a polyphenol that may render the
protection as an antioxidant against a range of disease-associated medical
conditions including tumorigenesis, oxidation, inflammation, apoptosis and
hyperlipemia. In addition to Alzheimer's disease and diabetes, taking curcumin
dietary supplements may help prevent or treat multiple myeloma, pancreatic
cancer, myelodysplastic syndromes, colon cancer, and psoriasis, according to
early studies.
Curcumin and silibinin
inhibit telomerase expression in T47D human breast cancer cells.
Asian Pac J Cancer Prev. 2013;14(6):3449-53
Inhibitory effects of silibinin and curcumin, two herbal substances, on
telomerase gene expression in breast cancer cells.
Forbes.com October 2013
Turmeric, the spice that gives curry and mustard their yellow color,
contains a chemical called curcumin that’s the subject of numerous
neurologic studies right now. Research has shown curcumin’s ability to boost
memory,
slow
the progression of Alzheimer’s and stimulate neurogenesis, which is the
process of creating new brain cells. Studies suggest curcumin may also clear
out amyloid plaques, the brain gunk thought to be a cause of Alzheimer’s,
and calm inflammation of brain and nerve cells.
NaturalNews.com
October 2013 When the researchers administered daily oral
curcumin treatments
of 80 mg for three days, significant changes occurred. The mercury induced
serum biochemical changes were reversed, as the liver and kidneys began
showing signs of repair.
Is Turmeric
As Effective As Fourteen Other Drugs? Sacred Plant’s Ingredient, Curcumin, Holds
Key To Health Benefits
MedicalDaily.com October 2013
Curcumin -- have gained attention in both the medical and media worlds, due to
research that points to the herb's preventative and therapeutic qualities for
diseases like arthritis, Alzheimer's and even cancer.
Turmeric
spice may have role in multiple myeloma therapy
OncologyNurseAdvisor.com October 2013
Curcumin, an active ingredient in the common kitchen spice turmeric, destroyed
multiple myeloma cells in recent lab experiments.
Put Some
Spice in Your Life
DocGiff.com October 5, 2013
Researchers have tested this spice as a cure for cancer and Alzheimer’s disease.
It’s actually the cause of the yellow color, curcumin in turmeric, which
interests scientists. Dr. Bharat Aggarwal, professor of cancer research at the
Anderson Cancer Center in Houston, said curcumin induced a programmed death of
cancer cells. In addition, it suppressed formation of new blood vessels that
nourished tumors. Rats, for instance, got fewer cancers of the breast and colon
when given curcumin.Researchers at Harvard went a step further and injected
curcumin into the bloodstream of mice with Alzheimer disease-like plaques. A
week later, studies showed a 30 percent decrease in these plaques. Research into
how this spice affects humans with Alzheimer’s disease is only in preliminary
stages.
No cure for Alzheimer’s disease, but curcumin may help
Foodconsumer.org October 2013
Epidemiological studies have shown that people
who eat a diet high in curcumin were at a lower risk of Alzheimer's disease,
suggesting that taking curcumin supplements may help prevent the disease. Indian
studies have already suggested that a high dose of curcumin like 6 grams of
curcumin per day can be used to prevent type 2 diabetes mellitus in people
living with prediabetes. Curcumin as an antioxidant has an antiinflammatory
effect and may potentially help prevent a variety of cancer.
Curcumin was a component of the spice Tumeric, and had been shown
to decrease the concentration of antioxidant defence substances within a cell.
Effect of curcumin on human colon cancer multidrug resistance in vitro and in
vivo Cancer Gene Therapy Week October 2013
Curcumin has strong reversal effects on the multidrug resistance of human colon
carcinoma in vitro and in vivo.
Suppository of wisdom
Journal of Crohn's and Colitis October 2013
Curcumin enemas may be effective in controlling disease activity in ulcerative
colitis.
Superfoods
ThirdAge.com September 2013
Canadian researchers reported that curcumin, found naturally in the spice
turmeric, may have “antitumor activity” and “continues to receive considerable
attention as a potent antioxidant and anti-cancer agent”. According to the Mayo
Clinic, “At this time, there isn't enough evidence to recommend curcumin for
preventing or treating cancer, but research is ongoing. Curcumin, a substance
found in the spice turmeric, has long been used in Asian medicine to treat a
variety of maladies. Now some research suggests that curcumin may help prevent
or treat cancer.
Antitumor
activity of novel curcumin analogs in hepatocarcinoma (HepG2) cells
Phys.org September 2013
Curcumin, a natural polyphenol of turmeric, continues to receive considerable
attention as potent antioxidant and anti-cancer agent. Numerous analogues of
curcumin have been synthesized and screened for their improved biological
activities.
Curcumin enhances the lung cancer chemopreventive
efficacy of phospho-sulindac by improving its pharmacokinetics
Int J Oncol. 2013 Sep
Curcumin, the principal bioactive component in turmeric, has demonstrated
versatile capabilities to modify the therapeutic efficacy of a wide range of
anticancer agents...Our results show that curcumin substantially improves the
pharmacokinetics of PS leading to synergistic inhibition of the growth of human
lung cancer xenografts, representing a promising drug combination.
Anti-cancer
effects of docosahexaenoic acid and curcumin
BMC Cancer September 2013
The combination of DHA and CCM is potentially a dietary supplemental treatment
for some breast cancers, likely dependent upon the molecular phenotype of the
cancer.
FoxNews.com Chris Kilham Medicine Hunter,
September 01, 2013 Turmeric root This yellow root contains a profoundly beneficial compound called
curcumin that possesses superior anti-inflammatory activity, aids the immune
system, enhances the brain, and protects your skin. Curcumin from turmeric is a
very popular anti-inflammatory remedy. You can sprinkle turmeric on food, cook
with it, or use curcumin supplements.
Korean J Physiol Pharmacol.
2013 August
Curcumin (diferuloylmethane), a polyphenol derived from the plant
turmeric (Curcuma longa Linn), is known for its antioxidant and
anti-inflammatory properties. Moreover, quite a few studies, including our own,
have shown that curcumin exhibits anticancer activities against various tumors,
including pancreatic, colon, ovarian, and breast cancers, by modulating multiple
signaling pathways. Curcumin has been reported to increase p53 signaling, which
upregulates the transcription of downstream genes such as p21 and Bax to induce
apoptosis in a variety of cancer cells. In addition, curcumin causes cancer cell
apoptosis, in part via suppression of Notch1 signaling.
Curcumin
Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs
Korean J Physiol Pharmacol.
2013 August
long-term curcumin administration may reduce lung inflammation and fibrosis
caused by radiation treatment.
BMC Complement Altern Med.
August 2013
Curcumin was found to ameliorate the abnormalities in the behavior and
brain glucose metabolism caused by CUS, which may account for its antidepressive
effects.
Dallas News, August 4, 2013
Curcumin can aid in many illnesses associated with inflammation, from cancer to
arthritis, and even Alzheimer’s disease. Now he has a study, published in July’s
Phytotherapy Research, that suggests curcumin is just as effective as Prozac, an
anti-depressant fluoxetine, in treating clinical depression.
BMC
Complementary and Alternative Medicine 1 August 2013
Curcumin was found to ameliorate the abnormalities in the behavior and brain
glucose metabolism caused by CUS, which may account for its antidepressive
effects.
Efficacy and
Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.
Phytother Res. 2013 Jul
This study provides first clinical evidence that curcumin may be used as an
effective and safe modality for treatment in patients with major depressive
disorder.
NYSE Post
Many studies now prove that turmeric/curcumin contain over 150 potentially
therapeutic traits, which include antioxidant, anti-inflammatory and anti-cancer
properties. Remarkably, curcumin is capable of crossing the blood-brain barrier,
which is one reason why it holds promise as a neuroprotective agent in a wide
range of neurological disorders. Researchers have investigated curcumin for its
potential role in improving Parkinson’s disease as well. Studies have shown
that it may even hold more promise than the drugs currently used for this
disorder.
The Healing Powers of Curcumin
Charles Poliquin
The many healing properties of curcumin are some of the most exciting
discoveries in the field of functional medicine. Curcumin counters inflammation,
detoxifies excess estrogen, supports the body’s antioxidant system, helps deal
with abnormal blood fat ratios (dyslipidemia) and offers protection against
colds and flu.
Kitchen
spice as good as some prescriptions
eMaxHealth-by Kathleen
Blanchard-Jul 14, 2013
Health benefits of curcumin in the spice turmeric include, but may not be
limited to the following, based on research studies.Liver
health,
Heart health, Pain relief,
Colon cancer, Breast cancer
prevention, Alzheimer’s disease, Obesity, Dental health, Acne,
Depression
TIME-Jul
4, 2013
Four in the morning, four more at
night. That's eight big mustard-yellow capsules every day. They contain
nothing but turmeric, a spice. But for ...
Science World
Report-Jul
3, 2013
An interesting study on 'turmeric,' one of
the key ingredient in many Asian dishes, reveals that
curcumin, a
naturally occurring compound in ...
Oncology Nurse
Advisor-Jul
2, 2013
Can
curcumin (the main component
of turmeric) help minimize side effects related to radiation therapy
|
Refinery29-June
25, 2013
Turmeric is anti-viral, anti-fungal,
and anti-inflammatory. Inflammation is the root of many chronic
diseases that cause our health to deteriorate — and
curcumin, ...
|
|
Daily Mail-June
17, 2013
New research shows the spice
curcumin can ease symptoms in benign prostatic hyperplasia, an
age-related non-cancerous condition which affects around 2.5 ...
|
|
A recent research claims that
curcumin, a compound of haldi, can relieve pain in
...
Curcumin is the principal curcuminoid of the popular Indian
spice turmeric.
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Curcumin as
a regulator of epigenetic events
Molecular Nutrition & Food Research 2013 June
The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that
enters into the composition of curry, already described for its diverse and
broad biological activities...is able to restore the epigenetic regulation
balance and appears as an attractive preventive and/or therapeutic approach
against human cancer.
Curcumin,
Anti-Oxidant, and Pioglitazone Therapy with Inclusion of Vitamin E in Non
Alcoholic Fatty Liver Disease
Gut 2013 June
Curcumin is a pan-antioxidant with anti-inflammatory, anti-apoptotic,
anti-microbial, and anti-fibrogenic properties...This study postulates the
effects of Curcumin plus vitamin E in NAFLD may prevent NASH with a modest anti-fibrotic
effects and necroinflammatory score; with impressive changes in adipokines
levels. Additive effects of Curcumin with vitamin E has significant effects on
Serum lipids and insulin sensitivity. Unavailability of Pre and post liver
biopsy was the limitation A large control trial needs to validate..
If you like curried food, then you
may be fighting aging while you eat. Two new studies suggest that
curcumin, the ingredient in turmeric that ...
|
Food
Consumer-June
10, 2013
Monday June 19, 2013 (foodconsumer.org)
-- A new study in Radiation Research suggests that women who are
diagnosed with breast cancer ...
|
One Green
Planet-June
31, 2013
Turmeric is full of powerful
antioxidants, including curcumin, which are known to fight
cancer-causing free radicals. Most research done on the ...
|
Synergistic
antibacterial effect of curcumin against methicillin-resistant Staphylococcus
Phytomedicine 2013 June
Curcumin, a natural polyphenolic flavonoid isolated from the rhizome of a plant,
Curcuma longa Linné., has been found to possess many beneficial biological
activities. The aim of this study was to investigate the synergistic effect of
curcumin and antibiotics as well as to determine the antibacterial activity of
Curcumin against specific MRSA strains.
Curcumin
inhibits telomerase and induces telomere shortening and apoptosis in brain tumor
cells
J Cell Biochem. 2013 June
Curcumin, a polyphenolic compound isolated from Curcuma longa (Turmeric) is
widely used in traditional Ayurvedic medicine. Its potential therapeutic effects
on a variety of diseases have long been known. Though anti-tumour effects of
curcumin have been reported earlier, its mode of action and telomerase
inhibitory effects are not clearly determined in brain tumour cells. In the
present study, we demonstrate that curcumin binds to cell surface membrane and
infiltrates into cytoplasm to initiate apoptotic events.
Curcumin
prevents obesity, diabetes and fatty liver
Food Consumer 2013 May
Curcumin an ingredient found in turmeric has been used to prevent many chronic
diseases including obesity, type type 2 diabetes and liver disease. Recent
studies show that this dietary supplement possesses potent antioxidant,
anticarcinogenic, antiinflammatory and hypoglycemic properties.
Citrus limonoids and curcumin additively inhibit
human colon cancer cells
Food Funct. 2013 April
This study provides compelling evidence of the pharmacodynamic additive effect
of limonoids and curcumin in inhibiting human colon cancer cells. These results
suggest that consumption of curcumin and limonoids together may offer greater
protection against colon cancer.
Antidepressant-Like Effects of Curcumin
CNS Neurol Disord Drug Targets. 2013 April
Curcumin, the major constituent of the spice turmeric produces a plethora of
biological actions that have translated in vivo into behavioral and
neurochemical effects in rodents that are also produced by clinically-used
antidepressants.
Curcumin
Attenuates Diet-Induced Hepatic Steatosis by Activating AMPK
Basic Clin
Pharmacol Toxicol. 2013 April
Curcumin is a well-known component of traditional turmeric (Curcuma longa),
which has been reported to prevent obesity and diabetes. The levels of total
cholesterol, fasting glucose and insulin in serum were decreased, and
HFD-induced impairment of insulin sensitivity was improved by curcumin
supplementation
Curcumin
inhibits UVB
Exp Dermatol. 2013 April
Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma
longa), which is commonly used as a spice. Recent studies have shown that
curcumin has a wide range of pharmacological activities, including
anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic
activities.... Curcumin prevented UVB-induced MMP expression
Curcumin
improves spatial memory and decreases oxidative damage in aged female rats
Biogerontology. 2013 April
Curcumin is the active component of curcuma longa and has shown antioxidant,
antiinflamatory and neuroprotective properties...curcumin supplementation
improves cognitive functions by decreasing the lipid peroxidation in brain
tissue of aged female rats.
Curcumin
And Curcumin-Like Molecules: From Spice To Drugs
Curr Med Chem. 2013 April
Curcumin is the major yellow pigment extracted from turmeric, a commonly used
spice in Asian cuisine that is used extensively in ayurvedic herbal remedies. A
number of studies have shown that curcumin can be a prevention agent and a
chemotherapeutic agent for colon, skin, oral and intestinal cancers. Curcumin is
also well-known for its anti-inflammatory and antioxidant properties, showing
high reactivity towards peroxyl radicals, and thus acting as a free radical
scavenger.
Genetic
And Epigenetic Studies For Determining Molecular Targets Of Natural Product
Anticancer Agents
Curr Cancer Drug Targets. 2013 April
Accumulating evidence has demonstrated that some common natural products (such
as epigallocatechin-3-gallate (EGCG), curcumin, genistein, sulforaphane (SFN)
and resveratrol) have anticancer properties through the mechanisms of altering
epigenetic processes and targeting cancer stem cells (CSCs). These bioactive
compounds are able to revert epigenetic alterations in a variety of cancers in
vitro and in vivo. They exert the anticancer effects by targeting various
signaling pathways related to the initiation, progression and metastasis of
cancer. It appears that natural products hold great promise for cancer
prevention and treatment by altering various epigenetic modifications.
Attenuation of age-related increase of protein carbonylation in the liver of
mice by melatonin and curcumin
Mol Cell Biochem. 2013 April
Curcumin, a phytochemical, has a wide variety of biological actions including
anti-inflammatory and antioxidative....the formation of protein carbonyls in the
liver of the aging mice can be prevented by the antioxidative effects of
melatonin and curcumin, which may provide health benefits in aging animals.
Curcumin
inhibits invasion and metastasis in K1 papillary thyroid cancer cells
Food Chem. 2013 April
Curcumin, the active constituent of dietary spice turmeric, possesses a strong
potential for cancer prevention and treatment...The findings showed that
curcumin might be an effective tumouristatic agent for the treatment of
aggressive papillary thyroid carcinomas.
Neuroprotection by curcumin in ischemic brain injury
PLoS One. 2013 April
Curcumin administration significantly reduced infarct size. Curcumin also
markedly reduced oxidative stress levels in middle cerebral artery occlusion (MCAO)
rats; Taken together, these findings provide evidence that curcumin protects
neurons against ischemic injury, and this neuroprotective effect involves the
Akt/Nrf2 pathway. In addition, Nrf2 is involved in the neuroprotective effects
of curcumin against oxidative damage.
Suppversity 2013 April
The stimulatory effect curcumin exerts on the AMPK expression
of adipocytes results in a down-regulation of PPAR-gamma in 3T3-L1 adipocytes
Supplement
Your Health With Curcumin
Wayne County Journal Banner 2013
April Curcumin may have the power to ease inflammation, promote healthy cell growth,
protect against ... The main bioactive compound in turmeric is called curcumin.
Marks Daily
Apple 2013 April
Curcumin Controls Blood Sugar: It switches on the liver genes that
keep glucose levels in check. It improves the pancreas’s ability to
make insulin and helps slow down the metabolism of carbohydrates
after meals. Curcumin Fights Cancer: It inhibits the genetic
switches that allow for cancerous cell growth to occur. Curcumin
Speeds Up Metabolism: USDA research shows that is enhances cellular
energy to speed metabolism. Curcumin Clears Plaque: It removes
amyloyd plaque buildup in the brain that can cause Alzheimer’s.
|
Acta Odontol Scand.
2013 March
Curcumin, an
active ingredient of turmeric, is proved to be a potential
candidate of controlling inflammation and bone resorption
(and) may decrease alveolar bone loss in the experimental
periodontitis rats via suppressing the expression of RANKL/RANK/OPG
and its anti-inflammatory properties.
Cardiovasc Hematol Agents Med Chem.
2013 March
Curcumins, derived from the spice
turmeric, and resveratrol, polyphenols found in grapes and red
wine respectively, in addition to their antioxidant and
anti-inflammatory properties, inhibit preadipocyte
proliferation, de novo lipogenesis and fat accumulation in
liver....The therapeutic use of
curcumin
and resveratrol, in the context of obesity as an initiator of
insulin resistance and hypertension, the two main features of
MS, together with the underlying mechanisms of action.
Mol Nutr Food Res.
2013 March
Curcumin (CUR),
demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC)
have been demonstrated as having antioxidant,
anticarcinogenic, and hypocholesterolemic activities. We
report the diverse antiatherogenic effects and mechanisms of
curcuminoids. Curcumin was the most potent antioxidant.
Diabetol Metab Syndr.
2013 March
Curcumin is known to have antioxidant and
anti-inflammatory properties. Curcumin
treatment improved gastric emptying by blocking the production
of oxidative stress, abolishing NF-kappaB signal transduction
and enhancing expression of SCF/c-kit in rats with diabetic
gastroparesis.
Food Chem Toxicol.
2013 March
Curcumin is a known cytoprotectant with
comprehensive anti-inflammatory and anti-cancerous
properties...Curcumin should be investigated as a potential safe
and remarkable approach in attenuating the adverse effects
induced by CP-related toxicants.
J Neuroimmune Pharmacol.
2013 March
Curcumin could be a candidate neuroprotective agent by
inducing macroautophagy, and needs to be further investigated by
clinical application in patients suffering Parkinson's disease.
Curcumin is known to have
antioxidant and anti-inflammatory properties. Curcumin
treatment improved gastric emptying by blocking the
production of oxidative stress, abolishing NF-kappaB signal
transduction and enhancing expression of SCF/c-kit in rats
with diabetic gastroparesis.
Endocrinology Section,
Department of Medicine, The University of
Arizona-Feb
19, 2013
The structural
and biological importance of curcuminoids in the
anti-breast cancer effects of turmeric and
contradict recent assertions that certain of the
curcuminoid metabolites studied here mediate
these anti-cancer effects.
|
mySteinbach.ca-February
2, 2013
Curcumin, which
provides the beautiful orange-yellow color to the
turmeric root, achieves its protective quality,
...
Synergistic anticancer effects of curcumin and resveratrol in
Hepa1-6 hepatocellular carcinoma cells.
Oncol Rep. 2013 February
Curcumin and resveratrol are the major anticancer constituents
of Curcuma aromatica and Polygonum cuspidatum, respectively.
Curcumin and resveratrol have been found to exhibit a
synergistic anticancer effect in colon cancer...Curcumin and
resveratrol is a promising novel anticancer strategy for liver
cancer. The present study also provides new insights into the
effective mechanism of paired-herbs in traditional Chinese
medicine.
Curcumin prevents liver fat accumulation and serum fetuin-A
increase in rats fed a high-fat diet
J Physiol Biochem. 2013 February
Curcumin is extracted from the rhizome Curcuma longa and has
been shown to possess potent antioxidant, anticarcinogenic,
anti-inflammatory, and hypoglycemic properties...Curcumin
treatment appeared to be effective in reducing liver
triglycerides and serum fetuin-A levels. These findings suggest
that the reduction of fetuin-A may contribute to the beneficial
effects of curcumin in the pathogenesis of obesity.
Integrating Dietary Supplements Into Cancer Care
Integr Cancer Ther. 2013 February
A list of leading supplements that have the best suggestions of
benefit was constructed by leading researchers and clinicians
who have experience in using these supplements. This list
includes curcumin...
Curcumin: An Orally Bioavailable Blocker of TNF and Other
Pro-inflammatory Biomarkers
Br J Pharmacol. 2013 February
Curcumin (diferuloylmethane), a component of turmeric (Curcuma
longa) that is very inexpensive, orally bioavailable, and highly
safe in humans, yet can block TNF-α action and production in in
vitro models, in animal models, and in humans. In addition, we
provide evidence for curcumin's activities against all of the
diseases for which TNF blockers are being used.
Curcumin prevents mitochondrial dysfunction in the brain of the
senescence-accelerated mouse
Neurochem Int. 2013 February
Curcumin emerges as a promising nutraceutical for the prevention
of neurodegenerative diseases that are accompanied or caused by
mitochondrial dysfunction.
Institute
of Anatomy, Munich, Germany.
2013 February
Combining Curcumin with conventional
chemotherapeutic agents such as 5-FU could provide more
effective treatment strategies against chemoresistant colon
cancer cells
Antidepressant-like effects of curcumin in WKY rat model of
depression is associated with an increase in hippocampal
BDNF.
Behav Brain Res. 2013
February
Department of Pharmacology, Howard University College of
Medicine
Curcumin is the principal active ingredient found in
turmeric (Curcuma longa), a plant used in traditional Asian
diets and herbal medicines. It is known to have a wide range
of biological actions including antidepressant-like effects
which have been observed in stress-induced depression
models...Evidence for an antidepressant-like effect of
curcumin, possibly through increased neurotrophic activity,
in the WKY model of depression, and support the notion that
curcumin may prove an effective and lasting natural
antidepressant.
Curcumin induces apoptotic cell death of activated human
CD4+ T cells via increasing endoplasmic reticulum stress and
mitochondrial dysfunction.
Int Immunopharmacol. 2013
February
Curcumin, a natural
polyphenolic antioxidant compound, exerts well-known
anti-inflammatory and immunomodulatory effects, the latter
which can influence the activation of immune cells including
T cells. Furthermore, curcumin can inhibit the expression of
pro-inflammatory cytokines and chemokines, through
suppression of the NF-κB signaling pathway. The beneficial
effects of curcumin in diseases such as arthritis, allergy,
asthma, atherosclerosis, diabetes and cancer may be due to
its immunomodulatory properties.
Neurobiological and pharmacological validity of curcumin in
ameliorating memory performance of senescence-accelerated
mice
Pharmacol Biochem Behav.
2013 February
Curcumin, a major active component of spic turmeric, could
increase the capacity of learning and memory in the aged
rat...Curcumin treatment could attenuate cognitive deficits
of SAMP8 mice in a dose-dependent manner by decreasing the
oxidative stress and improving the expression of p-CaMKII
and p-NMDAR1 in the hippocampus. Thus treatment with
curcumin may have a potential therapeutic agent for
aging-related cognitive dysfunctions.
Curcumin Inhibits UV Radiation-Induced Skin Cancer in SKH-1
Mice.
Otolaryngol Head Neck
Surg. 2013 February
Curcumin, a naturally occurring food substance and
anticarcinogenic agent, inhibited cutaneous squamous cell
carcinoma xenograft growth...Curcumin appears to inhibit
skin cancer formation and prolong time to tumor onset when
administered by either an oral or topical route.
Curcumin ameliorates arterial dysfunction and oxidative
stress with aging.
Exp Gerontol. 2013 February
Curcumin supplementation ameliorates age-associated large
elastic artery stiffening, vascular endothelial dysfunction,
oxidative stress and increases in collagen and AGEs in
mice...Curcumin may be a novel therapy for treating arterial
aging in humans.
Curcumin restores diabetes-induced neurochemical changes in
the brainstem of Wistarrats.
Eur J Pharmacol. 2013
February
Beneficial
effect of curcumin in diabetic rats by regulating the
cholinergic, insulin receptor and GLUT-3 in the brainstem
similar to the responses obtained with insulin therapy.
A potent neuroprotective modulator against Alzheimer
disease.
Fundam Clin Pharmacol.
2013 February
Some substances, such as Zn, s-Ethyl cysteine, s-propyl
cysteine, citicoline, rivastigmine, Vit E, memantine, tea
polyphenol, curcumin, caffeine, Alpinia galanga (L.)
fractions, and Bacopa monnieri could play a role in
improving memory performance and exert protective effects
against Alzheimer disease.
Complementary therapies in cystic fibrosis: nutritional
supplements and herbal products.
J Pharm Pract. 2013
February
Complementary
therapies in cystic fibrosis such as vitamin A, vitamin C,
vitamin E, zinc, omega 3 fatty acids, docosahexaenoic acid (DHA),
garlic, ginseng, and curcumin.
Oncol Rep.
March, 2013
Department of Pharmaceutical
Sciences, College of Pharmacy, Western University of
Health Sciences
Chemopreventive potential of a
combination of aspirin (ASP),
curcumin (CUR) and sulforaphane (SFN) in
low doses to human pancreatic cancer cells
Life Sci.
2013 March
Underlying molecular mechanism of
curcumin-induced apoptosis in human
hepatocellular carcinoma (HCC) Huh7 cells.
Cell Signal.
2013 March
The protective effects of
curcumin against OSI (oxidative
stress injury)
|
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Chiropractic Economics-Jan
11, 2013
Curcumin, which gives
turmeric its yellow color, has anti-inflammatory and
...
Curcumin initiates the self-destruction of cancer cells and
prevents their growth.
|
Palm Beach
Daily News-Jan
6, 2013
Curcumin, a phenol
responsible for making turmeric yellow, does much more than provide
numerous Indian dishes with that particular tint, according to Dr.
|
GroundReport Jan 2, 2013
Curcumin with its rich anti-inflammatory components. The spice is widely
used in India and it's interesting to note that elderly villagers in
India have one of the world's lowest rates of Alzheimer's.
|
GreenProphet Jan 2, 2013
This review of preclinical and clinical trials with curcumin
submitted to PubMed.gov is only one of many publications attesting to
its anti-inflammatory powers. |
eMaxHealth-Dec
13, 2012
If you currently take
over-the-counter or prescription medications to treat pain and other
symptoms of rheumatoid arthritis (RA), you may want to consider
spicing ...
|
Scoop.co.nz-Dec
10, 2012
Curcumin Curcumin is an
extract from the curry spice, turmeric (approximately 5% of turmeric
is ... Through clinical trials,
curcumin has
demonstrated antioxidant, ...
|
Voxy-Dec
10, 2012
Curcumin is an extract from
the curry spice, turmeric (approximately 5% of turmeric is
...
Through clinical trials, curcumin has demonstrated
antioxidant, ...
|
Natural
Products INSIDER-Dec
6, 2012
Curcumin, the principal
curcuminoid of the Indian spice turmeric, is a strong antioxidant
known to fight inflammation, but other research has centered on its
ability ...
|
7thSpace Interactive
-Dec
1, 2012
Methods: T47D cell line was
treated with different concentrations of
curcumin and
genistein, alone or in combination; added together or with
interval time.
|
ProHealth-Nov
13, 2012
We investigated the effects of
curcumin ingestion and aerobic exercise training on
... women were assigned to 3 groups: control, exercise, and
curcumin groups.
|
Curcumin extract for prevention of type 2 diabetes.
Diabetes Care. 2012 Nov;35(11):2121-7.
This study demonstrated that the curcumin intervention in a prediabetic
population may be beneficial. |
7thSpace
Interactive-Nov
1, 2012
Many cancers contain cell
subpopulations that display characteristics of stem cells. Because
these cancer stem cells (CSCs) appear to provide resistance to
...
|
nwitimes.com-Oct
29, 2012
Patients undergoing cancer treatment
often look to augment their health through alternative means. Many
integrative medical interventions can make a real
...
|
Medical Xpress-Oct
24, 2012
Dr Saparna Pai has been awarded an
Australian Academy of Science Early-Career Australia-India
Fellowship to investigate curcumin's action on immune cells
...
|
The Guardian
-Oct
17, 2012
RESEARCHERS have found that the
primary polyphenol in turmeric,
curcumin, is able to repair
and even regenerate the liver tissues in diabetic rats.
|
Food Product
Design-Oct
15, 2012
MUNICH—Curcumin, an active
component of turmeric that has been found to inhibit inflammation,
may help slow down prostate cancer metastases, according to
...
|
Examiner.com-Oct
14, 2012
Timothy J. Moynihan, M.D. has written
for Mayo Clinic that curcumin, which is a
... Some
research has suggested that curcumin may help prevent or
treat cancer.
|
allvoices-Oct
13, 2012
The poly-phenol found in turmeric
called curcumin known for its powerful
... In a
new study curcumin has been shown to have a new role when
it comes to ...
|
TruthDive-Oct
12, 2012
Curcumin is well tolerated
and is therefore, in principle, suitable both for prophylactic use
and also for the suppression of metastases in cases where an
...
|
HealthCanal.com-Oct
12, 2012
Curcumin is already known to
be a powerful antioxidant and an anti-inflammatory and could combat
beta amyloid, a protein responsible for Alzheimer's and
...
|
Gastroenterology
& Endoscopy News-Oct
11, 2012
More research is needed to determine
the efficacy of curcumin in the treatment of inflammatory
bowel disease (IBD), according to a systematic review of the
...
|
NutraIngredients.com-Oct
5, 2012
Curcumin, the natural
pigment that gives the spice turmeric its yellow colour, has
increasingly come under the scientific spotlight in recent years,
with studies ...
|
Radio Australia-Oct
4, 2012
Curcumin is the compound
that gives turmeric its rich yellow colour. Scientists have found it
is also a powerful antioxidant, an anti-inflammatory, and may halt
the ...
|
Dominican Today-Oct
3, 2012
Found in turmeric,
curcumin
displays anti-tumor and antioxidant properties.
Curcumin is
a popular Indian spice that is a member of the ginger family. It's
quite ...
|
Food Consumer-Oct
2, 2012
The study also showed that
intraperitoneal administration of
curcumin at a dose of
... For the study, one week after the treatments with fluoride
and curcumin, the
...
|
Food Product
Design-Oct
1, 2012
COLUMBUS, Ohio—Curcumin, a
compound found the popular Indian spice turmeric may help lower
inflammatory markers associated with heart disease,
...
|
indiatvnews.com-Sep
23, 2012
Curcumin is its major
component responsible for the spice's yellow colour and its
...
"It (curcumin) has been shown to be a good cure for gastric
ailments like ...
|
Sacramento Bee-Sep
20, 2012
Curcumin is felt to be the
primary active ingredient in turmeric. At the end of the study, none
of the people who was taking the
curcumin capsules had
developed ...
|
Natural Products
-Sep 18, 2012
Supplementing with 1 g/d of
curcumin for 30 days led to a significant reduction in serum
triglycerides, in a recent study published in
...
|
7thSpace
Interactive-Sep
16, 2012
Inhibition by
curcumin of
multiple sites of the transforming growth factor-beta1 signalling
pathway ameliorates the progression of liver fibrosis induced by
carbon ...
Food Consumer-Sep
5, 2012
Additionally, carnosic acid
exhibits synergy with turmeric/curcumin against breast
cancer cells. These two compounds inhibited the activity of the
purified ...
|
Stuff.co.nz-Sep
4, 2012
The controversial bit comes with his
inclusion of supplements like curcumin and
...
Curcumin, the pigment that gives the spice turmeric it's yellow
colour, is an ...
|
Sydney Morning
Herald -Sep
4, 2012
Supplements like
Curcumin,
the pigment that gives the spice turmeric it's yellow colour, is an
anti-inflammatory, which – in animal studies - shows promise against
both Alzheimer's and cancer....
|
eMaxHealth-Sep
1, 2012
Curcumin, a major component
of turmeric, is usually the ingredient people most associated with
providing health benefits. In fact,
curcumin has been the
subject ...
|
UPI.com-Aug
24, 2012
25 (UPI) --
Curcumin, found
in turmeric, stopped the potentially deadly Rift Valley
...
However, in the published article, we provide evidence that
curcumin may
...
|
Emory Health Now
-Aug
24, 2012
A recent article in Chemical &
Engineering News describes the promising properties of
curcumin,
a compound derived from turmeric, in models of Alzheimer's
...
|
News-Medical.net-Aug
22, 2012
Curcumin, the main compound
in the spice turmeric, prevents replication of
... However,
"we provide evidence that
curcumin may interfere with how
the virus ...
|
eMaxHealth-Aug
20, 2012
The popular spice
curcumin
has been shown to stop the Rift Valley fever virus dead in its
tracks, which may not seem highly relevant to people who don't live
in ...
|
ProHealth-Aug
17, 2012
Curcumin, a bioactive
component of the popular spice turmeric, “shows
... that
curcumin can stop multiplication of the potentially deadly
Rift Valley Fever virus in ...
|
Best Syndication-Aug
16, 2012
(Best Syndication News) - Researchers
from George Mason University found that turmeric's
curcumin
was able to stop the deadly Rift Valley Fever virus from
...
|
ScienceBlog.com
-Aug
16, 2012
Curcumin, found in turmeric,
stopped the potentially deadly Rift Valley Fever virus from
multiplying in infected cells, says Aarthi Narayanan, lead
investigator on ...
|
India West-Aug
16, 2012
Curcumin (the bioactive
component of turmeric, used in day-to-day cooking and
...
Studies on mice seemed to show that
curcumin actually
reversed a cause of ...
|
WebMD
-
August 2, 2012
Small Study Suggests
Curcumin
May Play a Role in Diabetes Prevention ... July 31, 2012 --
Curcumin, the substance found in the spice turmeric that gives
curry ...
|
Healthcare Today
-
August 2, 2012
Curcumin, a compound in the
spice turmeric, may help prevent diabetes in people who have
pre-diabetes, according to the research, which was published in the
...
|
Huffington Post
-
August 1, 2012
A curry compound could help to keep
diabetes at bay among people most at risk, a small new study shows.
The research, published in the journal Diabetes ...
|
GlobalPost
-
August 1, 2012
Curcumin, a component of
curry, was found to cut the risk of type 2 diabetes in a new study.
Researchers at the University of Nakomnayok in Thailand found that
...
|
Examiner.com
-
July 31, 2012
Curcumin, the spice known
for giving curry dishes their very distinct flavor and color was
placed under the microscope and unveiled some exciting results.
|
Foodbeat
-
July 13 2012
The individuals were randomly
assigned to take wither curcumin capsules or a ... The
daily dosage for those taking curcumin capsules was 250
milligrams of ...
|
Diets In Review
- July 12 2012
Curcumin is a compound in
turmeric, a spice in the ginger family that's most commonly found in
Indian cooking. According to an article in Reuters, previous lab ...
|
Huffington Post
-
July 3, 2012
A curry spice may do more than just
add some flavor to your dishes -- it could also help to preserve the
ability to walk in people who've had a ...
|
The International
News Magazine -
July 1, 2012
USA 30 June 2012. What is
Curcumin and why is this herb so popular? Why are the world and
the medical community going gaga behind this ...
|
News-Medical.net -
Jun 27, 2012
Researchers from the Department of
Neurosurgery at the David Geffen School of Medicine and the
Department of Integrative Biology and Physiology at UCLA have found
that a diet enriched with docosahexaenoic acid (DHA), an omega-3
fatty acid, and curcumin ...
News-Medical.net -
Jun 27, 2012
The second group consumed a standard
diet supplemented with docosahexaenoic acid, or DHA, and curcumin, a
compound in turmeric, an Indian curry spice. A third set of rats
received a standard rat diet and served as a control group.
New York Daily News -
Jun 27, 2012
Washington, June 27 — A diet enriched
with a popular omega-3 fatty acid and curcumin, found in Indian
curry spice turmeric, preserved walking ability in rats with
spinal-cord injury. The findings by researchers from the University
of California Los ...
Times of India -
Jun 27, 2012
WASHINGTON: A diet enriched with
curcumin, a component of the popular Indian spice turmeric, and
omega-3 fatty acid DHA can repair tissue damage and restore walking
abilities in rats with spinal-cord injury, a new study claims.
GlobalPost -
Jun 26, 2012
Researchers at UCLA found that rats
with spinal cord damage recovered faster when fed a diet rich in
omega-3 compound DHA and curcumin, often found in curry. Omega-3
fatty acid-rich foods such as flax seeds (above) may help to improve
walking ability ...
Independent
Online -
17 Jun
2012
US research has shown that
curcumin, which is found in the popular curry spice turmeric,
causes a sizeable increase in a protein that boosts the immune
system.
|
Food Consumer
-
11 Jun 2012
Tuesday June 2012 (foodconsumer.org)
-- A new report suggests that curcumin, a dietary
polyphenol found in the curry spice turmeric may be used as a ...
|
South Asia Mail
-
8 Jun 2012
The cooking spice turmeric is not
only a vital ingredient in many curries, it has also been used for
2500 years as a medicinal compound in the Ayurvedic system ...
|
Kansas.com
-
5 Jun 2012
To keep your brain young, get plenty
of vitamin D-3, coffee and curcumin (found in ... And if
you like coffee and curcumin, these help remove brain cell
poop, but ...
|
Hindustan Times
-
29 May 2012
Researchers in Oregon State
University in the US found that
curcumin, a major ... Prof
Gombart said the impact of curcumin wasn't nearly as potent
as that of ...
|
Newsmax Health
-
29 May 2012
Curcumin, found in the
cooking spice turmeric, boosts the immune system's ability ... New
research at Oregon State University has discovered that
curcumin
-- a ...
|
domain-B
-
29 May 2012
New research has discovered that
curcumin, a compound found in the cooking spice turmeric, can
cause a modest but measurable increase in levels of a ...
|
New Zealand
Herald -
28 May
2012
A new study by US researchers has
found curcumin - a compound in popular curry spice, ... "Curcumin
is generally consumed in the diet at fairly low levels," Prof ...
|
Huffington Post
Canada -
28 May
2012
Curcumin is a compound found
in turmeric, a flavourful, orange and yellow spice that is a key
ingredient in South Asian and Middle Eastern cuisine. The spice ...
|
JOE
-
28 May 2012
According to the Journal of
Nutritional Biochemistry, curcumin helps the body to fight
... Professor Adrian Gombart of Oregon State University said: 'Curcumin
is ...
|
French Tribune
-
28 May 2012
It has been subjected that
curcumin found in turmeric, which is spice, majorly used in
South Asian and Middle Eastern cuisine, can help prevent infection.
|
Minneapolis Star
Tribune -
26
May 2012
The researchers reported in the
Journal of Nutritional Biochemistry that
curcumin, a
compound found in the cooking spice turmeric, can cause a modest but
...
|
Calcutta
Telegraph -
26
May 2012
New Delhi, May 26:
Curcumin,
the yellow ingredient of turmeric, increases levels of an
anti-microbial protein, according to a new research study that
scientists ...
|
French Tribune
-
26 May 2012
It has been reported that
curcumin, a major component found in turmeric, which is vastly
used as a main ingredient in South Asian and Middle Eastern cuisine,
...
|
ProHealth
-
25 May 2012
Curcumin tripled production
of the CAMP peptide – the only one of its kind known in humans, and
able to kill a broad range of pathogens.
|
Medical Daily
-
25 May 2012
Eating curry may help prevent new
infections by strengthening the immune system, scientists say.
|
OregonLive.com
-
25 May 2012
Researchers at OSU's Linus Pauling
Institute discovered that curcumin, found in turmeric, can
boost levels of cathelicidin antimicrobial peptide, a protein known
...
|
Sci-News.com
-
25 May 2012
Curcumin, a principal
curcuminoid found in the popular Indian spice turmeric ... published
in the Journal of Nutritional Biochemistry, suggests that
curcumin, ...
|
Food Consumer
-
23 May 2012
Curcumin is a major
ingredient of the spice turmeric. Many studies have indicated
curcumin helps prevent cancer. A number of mushrooms known as
"medicinal ...
|
SheKnows.com
-
22 May 2012
A simple, but powerful formula that
includes curcumin, boswellia, DLPA, and ...
Curcumin
has become very popular as a supplement in the past few years.
|
The Sun
-
20 May 2012
Curcumin, the yellow
super-nutrient in turmeric, has health-promoting effects ...
designed to see whether curcumin can work alongside
chemotherapy drugs, ...
|
SBWire (press
release) -
18
May 2012
Curcumin found in turmeric
has several health benefits that Natural Health Sherpa ... In one
study that compared the effectiveness of
curcumin – the
active ...
|
Cordis News
-
8 May 2012
They will investigate whether tablets
containing curcumin, which is found ... This work will
build on previous studies showing that
curcumin can enhance
the ...
|
BBC
-
7 May 2012
Earlier studies have shown that
curcumin can enhance the ability of ... "The prospect that
curcumin might increase the sensitivity of cancer cells to ...
|
Technorati
-
6 May 2012
Researchers from UK have started
working on the curry ingredient
curcumin to find whether
curcumin can help in increasing the therapeutic ability of
...
|
CBC.ca
-
5 May 2012
A spice found in turmeric called
curcumin has already been linked to a range of health benefits
and previous studies have shown that it can beat cancer ...
|
CRIENGLISH.com
-
4 May 2012
Scientists will supplement standard
chemotherapy with pills containing
curcumin, a compound
found in the yellow curry spice turmeric.
|
Visit Bulgaria
-
3 May 2012
Yet again, it has been revealed that
curcumin, a compound found in turmeric, is effective in
enhancing the effect of chemotherapy.
|
Myjoyonline.com
-
2 May 2012
Curcumin, which is found in
the spice turmeric, has been linked to a range of ... Now a trial at
hospitals in Leicester will investigating giving
curcumin
...
|
Aberdeen Evening
Express -
1 May
2012
Scientists will supplement standard
chemotherapy with pills containing
curcumin, a compound
found in the yellow curry spice turmeric.
|
Medical Xpress
-
28 Apr 2012
Earlier studies have shown that
curcumin can enhance the ability of chemotherapy to kill bowel
cancer cells in the lab. The trial is being funded by Hope ...
|
This is
Leicestershire -
27 Apr 2012
Laboratory research has already shown
curcumin can improve the ... "The prospect that
curcumin might increase the sensitivity of cancer cells to ...
|
TopNews United
States -
26 Apr
2012
However, now it is expected that the
number would reduce, as a new study has been done, which has found
curcumin to be quite effective in treating cancer.
|
TopNews New
Zealand -
25 Apr
2012
Many studies have proposed that
chemical, Curcumin, which is present in turmeric, can be
beneficiary for many health ailments. It has been exaggerated that
...
|
Kozmedia News
-
24 Apr 2012
Curcumin, which is found in
the spice turmeric, has been linked to a range of health benefits.
Studies have already shown that it can beat cancer cells ...
|
Metro
-
23 Apr 2012
(Picture: PA) A joint Cancer Research
UK and University of Leicester team is hoping to discover whether
pills containing curcumin - a compound found in ...
|
Express.co.uk
-
22 Apr 2012
Now, patients with advanced bowel
cancer are set to be give tablets packed with
curcumin to
discover whether it can boost the effect of more powerful, ...
|
Nature.com
-
20 Apr 2012
Combined with two other kitchen
essentials — pepper and onion —
curcumin, the key compound
of turmeric, has been shown to control these metabolic parameters
...
|
Diabetes.co.uk
-
18 Apr 2012
Researchers have claimed that an
active ingredient of turmeric called
curcumin could help in
the fight against obesity and diabetes, as well as excessive ...
|
India Today
-
17 Apr 2012
Curcumin - an ingredient
derived from turmeric or haldi - combined with extracts ... The
combination which goes by acronym CPQ -
curcumin, piperine
(derived ...
|
Medical Daily
-
16 Apr 2012
Half of the patients were given pills
containing curcumin and the other half was given
curcumin-free placebo pills. The pills were given three days
before ...
|
Healthcare Today
-
16 Apr 2012
Of the 121 patients, all of whom had
received non-emergency bypass surgery between 2009 and 2011, half
were given one gram of curcumin capsules four times a ...
|
TopNews New
Zealand -
16 Apr
2012
“Curcumin has for many years
now been shown to reduce inflammation and to reduce oxygen toxicity
or damage caused by free radicals in a number of ...
|
Newstrack India
-
16 Apr 2012
Curcumin, the yellow pigment
found in the spice contains antioxidant and anti-inflammatory
qualities. Bypass surgery improves the blood flow to the heart.
|
Chicago Daily
Herald -
16 Apr
2012
Today their healing potential is
again being rediscovered, especially
curcumin. In one
recent medical study, curcumin was found to be better than
...
|
Chicago Tribune
-
13 Apr 2012
Half of those patients were given
one-gram curcumin capsules to take four times a day,
starting three days before their surgery and continuing for five
days ...
|
PsychCentral.com
- 11 Apr 2012
By Traci Pedersen Associate News Editor
Curcumin, a compound found in the spice turmeric, is able to prevent
the clumping of a protein associated with ...
Deccan Herald
-
7 Apr 2012
A study conducted in Japan on
curcumin, another name for turmeric, showed positive results in
... “Curcumin is used as a supplement in Japanese food.
|
Everyday Health
-
2 Apr 2012
And modern-day medicine has backed up
these claims with research into
curcumin, the active
ingredient in turmeric. Here's a recent example: At Baylor ...
|
Medscape
-
29 Mar 2012
Curcumin, a major component
of the spice turmeric, has been shown to have chemopreventive and
chemotherapeutic properties. Past research also demonstrates ...
|
Wonder Woman
-
28 Mar 2012
Diners could reach for the
resveratrol or curcumin the same way as they might for salt
or pepper, he said. "Once the nutraceutical is enveloped, ...
|
PR Web (press
release) -
27
Mar 2012
Administration of turmeric or
curcumin to diabetic rats reduced the blood sugar, ... Turmeric
and curcumin supplementation also reduced the oxidative
stress ...
|
Examiner.com
-
25 Mar 2012
Although it's premature to start
taking curcumin to treat Parkinson's disease, the popular
culinary compound found in the spice turmeric has shown promise ...
|
ProHealth
-
24 Mar 2012
Curcumin is a component of
the curry spice, turmeric. Recently a similar study involved
osteoarthritis patients.] Curcumin is known to possess
potent ...
|
7thSpace
Interactive (press release) -
24 Mar 2012
Curcumin is a principal
compound of turmeric, commonly used to treat tumors and other
diseases. However, its anti-cancer activity in human acute monocytic
...
|
Examiner.com
-
23 Mar 2012
Nutrition Horizon has reported "Curcumin
Shows Promise in Attacking Parkinson's Disease." Michigan State
University (MSU) researchers have found that ...
|
NutraIngredients.com
-
23 Mar 2012
Intake of the tumeric spice
curcumin could help to reduce clumping of proteins associated
with the onset of Parkinson's disease, according to new research.
|
Ecorazzi
-
23 Mar 2012
Curcumin, which the compound
that gives turmeric its distinct color, is considered ... Dr. Oz
suggests getting your daily does of
curcumin via turmeric
tea, ...
|
Care2.com
-
22 Mar 2012
The main ones include: anthocyanin,
curcumin, hesperetin, and quercetin in your diet. Don't
worry about remembering their names.
|
MyFox Detroit
-
22 Mar 2012
On Thursday, he explained the
medicinal secrets of Curcumin during FOX 2 News Morning. If
you'd like to meet Lemerond, he'll be at the Better Health Market
...
|
NewsPoint Africa
-
22 Mar 2012
As per a research, which has been
published in the Journal of Biological Chemistry, it has been
revealed that curcumin, an active compound found in
turmeric ...
|
Futurity:
Research News -
21 Mar 2012
By bumping up the speed of protein
folding, curcumin—a compound in the spice turmeric—moves it
out of a dangerous speed zone allowing it to avoid clumping ...
|
Netdoctor
-
21 Mar 2012
Curcumin, a compound found
in the spice turmeric, may be beneficial for people with Parkinson's
disease, US scientists say. About 120000 people in the UK ...
|
Newstrack India
-
21 Mar 2012
Curcumin? has been found to
be very effective in prevention of the accumulation of a ...
Moreover, curcumin is an active ingredient found in spice
turmeric.
|
Newstrack India
-
20 Mar 2012
Washington, March 21 (ANI):
Curcumin, a compound found in the spice turmeric, has been
found to be effective at preventing clumping of a protein involved
in ...
|
Doctor Tipster
-
20 Mar 2012
Curcumin, a compound of an
asian spice known as turmeric, can be the next cure for Parkinson
disease. It was discovered by researchers at Michigan State ...
|
Chemistry World
-
20 Mar 2012
To address this problem, Janaswamy
and his team encapsulated curcumin molecules (a plant ...
Schematic encapsulation of curcumin in the hydrocolloid
matrix.
|
CBS -
18 Mar 2012
Terry Lemerond is a natural health
expert who believes in the power of
curcumin something he
calls a super spice: “It's an amazing plant, ...
|
Medscape
-
15 Mar 2012
"This new study helped clarify the
key mechanisms involved, which will help us better understand the
usefulness of vitamin D3 and curcumin as possible ...
|
Natural Products
INSIDER -
14 Mar
2012
EuroPharma's support ensures the
latest published scientific and clinical research on turmeric and
its key beneficial compound, curcumin, will be available
...
|
UroToday
-
14 Mar 2012
Among the mediators of this effect of
smoking is nuclear factor-kappa B.
Curcumin suppresses
cellular transformation by downregulating the activity of ...
|
CalorieLab
Calorie Counter News -
13 Mar 2012
Previous studies demonstrated that
curcumin, an ingredient isolated from the spice turmeric,
induced the same activity.
|
Health.com
-
13 Mar 2012
Previous research by the same
University of California, Los Angeles, team found that therapy with
vitamin D3 and curcumin — a chemical found in the spice ...
|
Mail & Guardian
Online -
13 Mar
2012
The Indian spice turmeric contains
curcumin, which has been used for ... Scientific research
suggests that curcumin may help to prevent or treat cancer.
|
Huffington Post
-
12 Mar 2012
"This new study helped clarify the
key mechanisms involved, which will help us better understand the
usefulness of vitamin D3 and curcumin as possible ...
|
Surviving
Mesothelioma -
11 Mar 2012
A team of researchers at Keio
University in Tokyo report that
curcumin, the primary
component in ... “Curcumin, which has a long history as a
dietary spice, ...
|
The Myeloma
Beacon -
10 Mar
2012
The Australian researchers also found
that patients had reduced levels of bone breakdown while taking
curcumin. “A number of the patients in this study did ...
|
Examiner.com
-
8 Mar 2012
Curcumin is a chemical found
in turmeric spice. Scientists believed that
curcumin, like
Vitamin D3, stimulated the immune system to clear amyloid beta.
|
EmpowHer
-
7 Mar 2012
Curcumin, found naturally in
turmeric spice, has also been reported to have significant
anti-inflammatory properties. Dr. Rebecca A. Taylor and Dr. Mandy C.
|
eMaxHealth
-
6 Mar 2012
"This new study helped clarify the
key mechanisms involved, which will help us better understand the
usefulness of vitamin D3 and curcumin as possible ...
|
Sarasota
Herald-Tribune -
5 Mar 2012
Dr. Mike carries a mustard pack in
his pocket to get a daily dose of
curcumin, the power drive
in turmeric (it's what makes mustard yellow) that protects ...
|
HealthCMI
-
3 Mar 2012
New research demonstrates that
acupuncture combined with oral
curcumin intake ...
Researchers examined the efficacy of
curcumin and
acupuncture both ...
|
The Idaho
Statesman -
2
Mar 2012
Dr. Mike carries a mustard pack in
his pocket to get a daily dose of
curcumin, the power drive
in turmeric (it's what makes mustard yellow) that protects ...
|
The Checkup
-
20 Feb 2012
In their study findings, researchers
learned that curcumin increased the ... In addition,
curcumin was found to be a strong fighter of both cell cycle
and ...
|
MSN NZ News
-
19 Feb 2012
One of the chemicals in the spice
turmeric, curcumin, has been shown to prolong the life of
fruit flies suffering from similar nervous disorders, ...
|
Dromore Today
-
19 Feb 2012
The study in question tested the
effects of curcumin (a chemical found in the spice ... It
found that curcumin improved lifespan and activity in some
...
|
Littlehampton
Gazette -
17 Feb
2012
The study in question tested the
effects of curcumin (a chemical found in the spice ... It
found that curcumin improved lifespan and activity in some
...
|
thejournal.ie
-
16 Feb 2012
CURCUMIN, WHICH IS extracted
from the turmeric root, could help reduce the ... The team behind
the research say that curcumin has been “reported to have
...
|
AOL Lifestyle UK
-
16 Feb 2012
The research tested fruit flies with
nervous disorders and found that those given
curcumin, a
chemical found in turmeric, lived 75% longer, ...
|
Insideireland.ie
-
16 Feb 2012
Tests carried out on fruit flies
found that those given curcumin – the key ...
Curcumin,
extracted from the root of tumeric, has been used as medicine for
...
|
San Francisco Bay
Area Today -
10
Feb 2012
Curcumin, a natural phenol
and derivative of turmeric, may be responsible for many of these
effects — particularly the anti-cancer benefits.
|
Oman Tribune
-
7 Feb 2012
Scientists are particularly intrigued
by curcumin, the active ingredient in turmeric, ... Animal
research shows curcumin reduces amyloid plaques and lowers
...
|
MarketWatch
(press release) -
6 Feb 2012
Curcumin, a natural phenol
and derivative of turmeric, may be responsible for many of these
effects -- particularly the anti-cancer benefits.
|
Zee News
-
1 Feb 2012
New Delhi: Researchers at UCLA`s
Jonsson Comprehensive Cancer Centre have found that
curcumin,
the main component in the spice turmeric, suppresses a ...
|
Innisfil Scope
-
31 Jan 2012
The active ingredient in turmeric is
curcumin. The medicinal properties of this spice are
constantly being discovered over the centuries.
|
Mother Nature
Network -
27 Jan
2012
Doctors at UCLA recently found that
curcumin, the main component in turmeric, appeared to block
an enzyme that promotes the growth of head and neck cancer.
|
Futurity:
Research News -
19 Jan 2012
... pursuing new ways to attack
Parkinson's disease, including a number of naturally occurring
compounds, such as curcumin, a compound found in tumeric.
|
Turn to 10.com
-
13 Jan 2012
"Curcumin is in curry powder
and we're finding it's a very potent anti-inflammatory and anti-amyloid
agent. So, it protects the brain," Small said.
|
NewsWithViews - TOP 10
HEALTH STORIES
Extensive research over the past five decades has indicated that
curcumin reduces blood cholesterol levels; prevents low-density
lipoprotein oxidation; inhibits platelet aggregation; suppresses
thrombosis and myocardial infarction; suppresses symptoms associated
with type II diabetes, rheumatoid arthritis, multiple sclerosis, and
Alzheimer’s disease; inhibits HIV replication; suppresses tumor
formation; enhances wound healing; protects against liver injury;
increases bile secretion; protects against cataract formation; and
protects against pulmonary toxicity and fibrosis. These divergent
effects of curcumin seem to depend on its pleiotropic molecular effects,
including the regulation of signal transduction pathways, and direct
modulation of several enzymatic activities. Most of these signaling
cascades lead to the activation of transcription factor. |
New Mexico
Business Weekly -
21 Dec 2011
UNM researchers found that a compound
in turmeric called curcumin could stop ... So the
researchers developed a synthetic version of
curcumin,
which they ...
|
Winston-Salem
Journal -
18 Dec
2011
Two years of taking NSAIDs and other
pain relievers didn't help, but I started taking
curcumin
capsules three days ago. I am now 50 percent pain-free, ...
|
Canadian National
Newspaper -
16
Dec 2011
Say hello to our newest aging fighter
called curcumin. ...
Curcumin, a compound found in
turmeric, has even been shown to help clear away the brain plaque
...
|
TMR Zoo
-
13 Dec 2011
by Dominick Walsh December - 13 -
2011 A review of literature by scientists from the University of
Buffalo concluded that curcumin helps regulate fat ...
|
Natural Standard
Blog - 12 Dec
2011
Curcumin is the
yellow-colored primary active constituent derived from turmeric and
is commonly used to color foods, cosmetics and other substances. ...
|
Care2.com
-
11 Dec 2011
Curcumin – a derivative of
turmeric, and the pigment that gives the ... Each 100 grams of
turmeric contains an estimated three to five grams of
curcumin.
...
|
San Antonio
Express -
7 Dec
2011
Two years of NSAIDs and other pain
relievers have not helped, but I started taking
curcumin
capsules three days ago. I am now 50 percent pain-free, ...
|
Care2.com
-
2 Dec 2011
Curcumin, the primary active
ingredient in turmeric prevents the development of plaque in the
brain and also has anti-pain and anti-inflammatory properties
|
Hairloss Talk
-
16 Nov 2011
Curcumin
...
|
Inquirer.net -
Tessa R. Salazar
-
7 Nov 2011
The compound
curcumin gives turmeric its golden yellow
color. A number of recent investigations of
curcumin have
shown its efficacy in ...
|
The Virginian-Pilot
-
4 Nov 2011
A member of the ginger family,
curcumin is a naturally
occurring chemical found in turmeric, derived from the root of the
“Curcuma longa” plant native to ...
|
The Desert Sun
-
2 Nov 2011
Curcumin: Part of the spice turmeric is prevalent in Indian
foods. There are many tests using
curcumin that have had
successful animal and lab results in
...
|
Siliconindia.com
-
24 Oct
2011
Curcumin is the main therapeutic ingredient
in turmeric which acts as great
... Research
shows that Curcumin suppresses pain through
a similar mechanism as
...
Focus Taiwan News Channel
-
10 Oct 2011
Taipei, Oct. 8 (CNA) Taiwanese researchers
have discovered that
curcumin, a
compound that gives turmeric its yellow
color, is effective in inhibiting liver
...
|
Times of India
-
9
Oct 2011
... look for ingredients with
antioxidants like vitamins C, E or a whole
range of botanicals like green tea,
grapeseed or pomegranate extract,
curcumin,
...
|
Bellingham Herald -
Kay Judge -
Maxine Barish-Wreden
-
8
Oct 2011
... including SAMe, ashwagandha,
avocado/soybean unsaponifiables, boswellia,
bromelain, cat's claw,
curcumin
(turmeric), devil's claw, ginger and willow.
...
|
New Zealand Herald
-
7
Oct 2011
Another September report by scientists at
UCLA found that
curcumin,
...
Tests involved human volunteers eating
curcumin tablets and showed that the
compound ...
|
NJ TODAY
-
6
Oct 2011
Turmeric, a popular spice contained in curry
powder, contains
curcumin.
Curcumin gives turmeric its yellow
pigment and may reduce the risk of cancer,
...
|
Fitness Goop -
Claudia Pillow
-
5 Oct 2011
Turmeric contains
curcumin which
inhibits enzymes that participate in the
synthesis
... The natural
anti-inflammatory activity of
curcumin
is comparable in
...
|
Huffington Post Canada
-
4
Oct 2011
Turmeric contains
curcumin and
curcuminoids, which are powerful
anti-inflammatory phytochemicals that act as
natural cyclooxygenase-2 (COX-2) inhibitors
in ...
|
ABC News
-
3
Oct 2011
Curcumin helped prevent the growth
of tumors tied to colon cancer,
...
"Our research found that
curcumin
was able to ignite the body's own tumor
suppression
...
|
Live in the Now -
John Phillip
-
2 Oct 2011
In addition to a calorie restricted diet,
the authors cite vitamin E, dietary
polyphenols (including GSPE and
resveratrol),
curcumin, spices and
...
|
The National -
Charles Crowell
-
1 Oct 2011
Last October, researchers from Saint Louis
University in the US identified
curcumin
- a chemical contained in the curry spice
turmeric - as showing promise
...
|
KMGH Denver
-
30 Sep 2011
Turmeric, sometimes called
curcumin,
is a mustard-yellow spice from Asia.
Scientific studies have shown that turmeric
may help arthritis by suppressing
...
|
FYI Living -
Dean A. Haycock
-
29 Sep 2011
A review of the few research papers that
describe experiments testing the
effectiveness of herbs suggests that aloe
vera, purslane and
curcumin may
have ...
|
The Express Tribune -
Rayan Khan
-
29 Sep 2011
In its chemistry, turmeric includes
curcumin, “shown to exhibit
antioxidant, anti-inflammatory, antiviral,
antibacterial, antifungal and anticancer
...
|
Medscape
-
28 Sep 2011
Curcumin reduces indomethacin-
induced damage in the rat small intestine.
J. Appl. Toxicol. 27(6), 551–560 (2007).
Hayllar J, Smith T, Macpherson A et al.
...
|
EmpowHer -
Linda Fugate
-
28 Sep 2011
Studies cited by Shabbeer showed similar
results for turmeric and its primary active
constituent,
curcumin. These
results were based on cell cultures in the
...
|
Chicago Tribune -
Joe Graedon -
Teresa Graedon
-
28 Sep 2011
One component,
curcumin, appears to
be responsible. While physicians await the
results of clinical trials (Cellular and
Molecular Life Sciences, June 2008),
...
|
Fox News -
Chris Kilham
-
28 Sep 2011
According to two of the authors of the
study, Dr. B. Anthony and Dr. R.
Kizhakedath, the herbal combination of
curcumin derived from turmeric and
boswellia
...
|
Livemint -
Vasudha Rai
-
26 Sep 2011
Even
curcumin, an antioxidant found
in turmeric, has been shown to reduce
physical exhaustion in mice because of its
anti-inflammatory effects.
...
|
Curcumin
as "curecumin"
Dynamic Chiropractic -
David Seaman
-
26 Sep 2011
Curcumin as "curecumin": from
kitchen to clinic. Biochem Pharmacol,
2008;75:787-809. Ozgoli G, Boli M, Moattar
F. Comparison of effects of ginger,
...
|
Nigerian Tribune -
Sade Oguntola
-
23 Sep 2011
Turmeric (curcumin), which is an
ingredient in Indian curry protects against
cancer. Red pepper which is used widely in
Nigerian cooking has been shown to
...
|
Voice of America
-
22 Sep 2011
Much of his research focuses on
curcumin,
a natural substance used to make turmeric, a
chief ingredient in curry sauces, which has
been shown to be
...
|
MedIndia
-
20 Sep 2011
Now researchers say that the
curcumin
in the spice suppresses a cell signaling
pathway behind the growth of head and neck
cancer. ...
|
The Province -
Elaine O'Connor
-
19 Sep 2011
Try spices like turmeric, as one of its
components,
curcumin may have some
protective effects. Increase your intake of
Omega-3s from sources like cold water
...
|
Imperial Valley News -
Kim Irwin
-
18 Sep 2011
Los Angeles, California -
Curcumin,
the main component in the spice
...
"This study shows that
curcumin can
work in the mouths of patients with head and
...
|
Killeen Daily Herald -
Candace Mullen
-
16 Sep 2011
Curcumin, the active ingredient,
has antioxidant properties, which some claim
may be as strong as vitamins C and E.
Turmeric is an ancient spice,
...
|
UCLA's
Jonsson Comprehensive Cancer Center, that found
that curcumin...
UC Los Angeles
-
16 Sep 2011
... professor-in-residence of head
and neck surgery and a researcher at UCLA's
Jonsson Comprehensive Cancer Center, that
found that
curcumin, the major
...
|
DigitalJournal.com -
Elizabeth Cunningham Perkins
-
15 Sep 2011
Curcumin spice, made from drying
and grinding turmeric plant roots into the
bright, deep yellow key ingredient of curry
powders, kills head and neck cancers
...
|
Medical News Today -
Grace Rattue
-
15 Sep 2011
This study shows that
curcumin can
work in the mouths of patients with head and
... A 2005 investigation by Wang and
her team first revealed that
curcumin
...
|
Rundtownnews.co.uk -
Edwin Cheeseman
-
15 Sep 2011
The resulting spice Turmeric and its active
ingredient
Curcumin are worth
mentioning briefly because of the wide range
of reported benefits some of which
...
|
Inventorspot
-
15 Sep 2011
by T Goodman The turmeric root and ground
turmeric (curcumin): image via
thecamreport.com A pilot study conducted by
researchers at UCLA's Jonsson
...
|
Empowered News
-
15 Sep 2011
The result indicates
curcumin,
turmeric's main component, has the ability
... There were also previous studies
suggesting
curcumin as an effective
treatment
...
|
Care2.com
-
14 Sep 2011
by Kristina C.
Curcumin, which is
the main component in turmeric, a spice used
in curry, can set off cancer-killing
mechanisms in human saliva in people
...
|
The Atlantic Wire
-
14 Sep 2011
In a study due to be published on Thursday,
researchers at UCLA's Jonsson Comprehensive
Cancer Center describe how
curcumin,
the primary component of
...
|
TopNews New Zealand -
Pallavi Sharma
-
14 Sep 2011
"This study shows
curcumin can work
in the mouths of patients with head and neck
malignancies and reduce activities that
promote cancer growth",
...
|
Food Consumer
-
14 Sep 2011
By Dr. Mercola
Curcumin – a
derivative of turmeric, and the pigment that
gives the
... Most notably,
curcumin is known for its potent
anti-inflammatory
...
|
Times of India
-
14 Sep 2011
Researchers at UCLA's Jonsson Comprehensive
Cancer Centre have found that
curcumin,
the main component in the spice turmeric,
suppresses a cell-signalling
...
|
TheNewsTribune.com
-
13 Sept 2011
Researchers at the center were exploring the
use of
curcumin, a component of
turmeric, to suppress the uncontrolled
growth of certain cells,
...
|
Malaysia Star
-
12 Sept 2011
In recent years, nutrients such as
standardised water-soluble
curcumin
(turmeric) extracts and resveratrol have
shown early promise as an anti-inflammatory
...
|
Huntington Herald Dispatch
-
11 Sept 2011
Like many yellow mustards (not Dijon), it's
rich in turmeric, the source of
cancer/arthritis/Alzheimer's-fighting
curcumin. Be like Dr. Mike: Sprinkle
these ...
|
Live in the Now -
John Phillip
-
10 Sept 2011
Many natural substances including
resveratrol,
curcumin and
blueberries have shown promise in preventing
this devastating form of dementia, but no
therapy ...
|
The Province -
Mehmet Oz -
9
Sept 2011
Like many yellow mustards (not Dijon), it's
rich in turmeric, the source of
cancer/arthritis/Alzheimer's-fighting
curcumin. Sprinkle these seasonings on
...
|
Sun.Star -
Zosimo T. Literatus
-
6 Sept 2011
THE wonders of
curcumin, the active
ingredient in kitchen spice turmeric (Curcumin
longa), work not only on stews but also in
...
|
The Hindu
-
4
Sep 2011
Curcumin, the active ingredient
that gives turmeric its characteristic
yellow ... In 2007, US researchers
reported that
curcumin helped
stimulate immune
...
|
The News International
-
3
Sep 2011
Curcumin, which gives the curry
spice turmeric its bright yellow color,
... Their studies show that
curcumin
can be used to suppress inflammation in
tendon ...
|
Sunday Leader
-
3
Sep 2011
The key ingredient in the curry is
curcumin, a component of the spice
turmeric.
Curcumin appears to
prevent the spread of amyloid protein
plaques – thought
...
|
Food Consumer
-
1
Sep 2011
Turmeric /
curcumin: A study in the
Journal of Alternative and
... This
is most likely related to the
anti-inflammatory effects of
curcumin
-- the pigment
...
|
The Seattle Times -
Sam Mcmanis
-
29 Aug 2011
The spice
curcumin does help treat
inflammatory arthritis and tendinitis,
according to researchers at the University
of Nottingham in
...
|
News-Medical.net
-
29 Aug 2011
Ms Rogers' research demonstrates the ability
of curcumin, an extract of the
spice turmeric, to protect kidney cells from
organ damage from blood flow during
...
|
Seattle Post Intelligencer
-
29 Aug 2011
With your daily dose of these fatty acids,
eat anti-inflammatory nutrients such as
catechin, found in green tea and other
plants, and
curcumin,
...
|
Sunday Leader
-
27 Aug 2011
Sprinkling
curcumin powder into
your favorite dishes, adds many years to
your life. Most diseases are caused by
chronic inflammation, and
curcumin
is ...
|
Ottawa Citizen -
Julie Beun
-
27 Aug 2011
... scientists are focusing on things
such as vitamin C and E, Ginkgo biloba,
curcumin from turmeric and caffeine.
Resveratrol from red wine and dark grapes
...
|
Sun.Star -
Zosimo T. Literatus
-
5 Aug 2011
Its active ingredient is called “curcumin,”
or more scientifically precise,
... A
recent review of all studies on
curcumin
confirmed its effectiveness
...
|
Jerusalem Post -
Natalie Marx
-
4 Aug 2011
The rates of Alzheimer's are much lower
among the elderly in India than in the West,
and early studies show that
curcumin,
an antioxidant phytochemical
...
|
Food Consumer
-
3
Aug 2011
Both vitamin D and
curcumin, the
pigment that gives spicy turmeric its
yellow-orange color,
...
Curcumin
prevents the spread of amyloid protein
plaques, ...
|
Brightly coloured turmeric not only makes
your curries taste fab, but it contains
curcumin, an active ingredient that
breaks down high-protein dishes, burns fat
and holds back the growth of new fat tissue,
according to The Journal of Nutrition. 22.
...
FM.co.za - Jul 6,
2011
There are several painkilling herbs,
including turmeric — which contains the
anti-inflammatory
curcumin — and
ashwaganda, used for centuries in Indian
Ayurvedic medicine. In one animal study,
cited in the Journal of Ethnopharmaceuticals,
...
Other phytochemicals that also inhibit
amyloid fibril formation in vitro include
resveratrol., tannic acid,
curcumin,
rosmarinic acid, wine related polyphenols,
and epicatechin gallate, according to a
review authored by Ehud Gazit and colleagues
of Tel ...
Turmeric (curcumin) has
anti-inflammatory properties, is healthy to
the liver and gallbladder, and is cancer
preventative. An increasing body of
scientific research is showing turmeric to
be one of the most valuable medicinal spices
with potent
...
Here are 12 foods that can help you lose
weight and gain health: Turmeric :
Curcumin, the active component of
turmeric, is an object of research owing to
its properties that suggest they may help to
turn off certain genes that cause scarring
and ...
FYI Living -
Jo Anne Kappel
-
28 Jul 2011
Turmeric is an Indian spice that contains
curcumin, a powerful antioxidant
and ... It was recently reported that
curcumin has been shown to have
anti-cancer
...
|
Malaysia Star
-
26 Jul 2011
Specific foods like garlic, cruciferous
greens (eg broccoli, sprouts), and green
pepper and
curcumin (tumeric) also
enhances the detoxification pathway.
...
|
Food Consumer
-
23 Jul 2011
They also pointed out a potential benefit of
combining ALA with other nutraceuticals like
curcumin, EGCG from green tea, and
docosahexaenoic acid (DHA) from
...
|
Live in the Now -
John Phillip
-
22 Jul 2011
Similar to super nutrients such as
resveratrol,
curcumin and green tea
extract, bromelain is a potent compound that
fights cancer by dissolving unnecessary
...
|
Food Consumer
-
22 Jul 2011
Curcumin (turmeric) was by far the
#1 food, with 26 studies attesting to its
efficacy. Paprika came in at #2 with 6
studies. Cancer is, by and large,
...
|
7thSpace Interactive (press
release) -
21 Jul 2011
These natural products are also reviewed for
their therapeutic potentials, including
flavonoids (gambogic acid,
curcumin,
wogonin and silibinin),
...
|
RDH -
Nancy W. Burkhart
-
20 Jul 2011
Other studies have suggested that both
lycopene and
curcumin may have
benefits in precancerous lesions. The
benefits of both antioxidant ability and
...
|
TakePart - Inspiration to
Action -
20 Jul 2011
According to a 2009 study by Professor
Murali Doraiswamy, director of the Mental
Fitness Laboratory at Duke University
Medical Center, eating more
curcumin,
...
|
7thSpace Interactive (press
release) -
20 Jul 2011
The current investigation was undertaken to
examine the effectiveness of the combination
therapy of dasatinib (a Src inhibitor) and
curcumin (a dietary
...
|
Food Consumer
-
19 Jul 2011
Curcumin: In a study of
osteoarthritis patients, those who added 200
mg of
curcumin a day to their
treatment plan had reduced pain and
increased mobility.
...
|
Hernando Today -
Jody Bowes
-
14 Jul 2011
In particular they say many customers
ascribe to the health benefits of turmeric
and curcumin, two common
ingredients in curry.
...
|
Fox News -
Chris Kilham
-
14 Jul 2011
This yellow root contains a profoundly
beneficial compound called
curcumin
that possesses superior anti-inflammatory
activity, aids the immune system,
...
|
Jerusalem Post -
Kathryn Rubin
-
13 Jul 2011
An active component of turmeric,
curcumin is believed to be the main
... A potent anti-inflammatory,
curcumin effects are even comparable to
drugs, ...
|
becomegorgeous.com - Jun 30,
2011
Curcumin is the element that gives the yellowish
shade to this veggie. This natural cleansing food is
considered one of the most efficient remedies to
eliminate toxins from the liver and the organism in
general. Sprinkle a few pinches of turmeric
...
Food Consumer -
Jun 27, 2011
This is most likely related to the anti-inflammatory
effects of curcumin -- the pigment that gives the
turmeric spice its yellow-orange color.
Curcumin
has been shown to influence more than 700 genes, and it
can inhibit both the activity and the
...
Care2.com -
Jun 24, 2011
I've previously written about a number of different
foods found to have particularly powerful epigenetic
influence, such as broccoli and resveratrol, but many
researchers consider the
curcumin in turmeric to
have the greatest potential in combating
...
PR Newswire
(press release) - Jun 23, 2011
In a study published in the journal Gastroenterology,
entitled "Novel Evidence for
Curcumin-induced DNA
Methylation Changes in Colon Cancer Cells,"(1) Dr. Goel
examined epigenetic expression in colon cancer cells and
the influence of curcumin on cancer
...
Thanks to its active ingredient,
curcumin,
turmeric has been credited with such a wide range of
health benefits that it's been called the "spice of
life". Research has shown it could have an effect in
stopping cancer spreading and in treating arthritis
...
Bangkok Post -
Jun 19, 2011
This is because,
curcumin, a substance found in
turmeric is being studied for its possible benefits to
those laid low by Alzheimer's disease, arthritis and
other clinical disorders. Importantly, it may show the
promise of having curable and preventive
...
The institute notes that other naturally occurring
compounds are chemopreventive (or cancer-preventive),
including "resveratrol" from red wine; grapes; and "curcumin"
from turmeric powder. The institute, a separate entity
from Hormel Foods Corp.,
...
She is currently on continuous low maintenance
chemotherapy treatment and taking an organic supplement,
curcumin, which she started in February. “I have
a lot of aches and pains,” she said. “And I've shrunk in
height three inches, too,
...
Not long ago, researchers at the world-renowned University
of Texas MD Anderson Cancer Center published a
groundbreaking scientific review of their favorite
anti-cancer nutrient – curcumin.
Curcumin,
along with several other nutrients
...
The omega-3 in walnuts helps resist inflammation and
balance hormones; one cup of apple juice is chock-full
of vitamin C and ginger aids digestion and metabolism;
eggplant has a high-quality amino acid protein profile
and turmeric is high in
curcumin,
...
Fish oil contains omega-3 essential fatty acids which
reduce inflammation. Vitamin E and turmeric can also aid
in the battle against pain and inflammation.
Curcumin
is the ingredient that gives turmeric its distinctive
yellow-orange color. ...
In addition, studies indicate that
curcumin, its
active ingredient, may slow certain types of cancer.
It's also good as a topical treatment for sore or
strained muscles, and taking it in food or in capsules
can relieve inflammation associated with
...
Konrad L, Müller HH, Lenz C, Laubinger H, Aumüller G,
Lichius JJ. Planta Med. 2000 Feb;66(1):44-7. 6. Novel
anti-prostate cancer curcumin analogues that
enhance androgen receptor degradation activity. Shi Q,
Shih CC, Lee KH. Anticancer Agents Med Chem.
...
Examples of dietary agents that can interfere with
tumorigenesis — or the development of tumors in cancer —
and activate tumor suppressor genes include spices, such
as curcumin (turmeric); genistein, a polyphenol,
an antioxidant, found in soybeans;
...
Coeur d'Alene
Press - Jun 1, 2011
The link to diet and Alzheimer's Disease is less clearly
established, but new information on
curcumin
(found in turmeric) may prove to be helpful. The brain
is particularly vulnerable to oxidative damage due to
its high rate of metabolism and
...
Turmeric is loaded with the antioxidant
curcumin, a potent
anti-inflammatory agent known to help reduce psoriasis and heal skin
damaged by UV rays and other environmental factors. Vitamin C ester
imparts a smooth, porcelain-like appearance.
...
The Union of Grass Valley -
May 31, 2011
British immigrants from the Middle East have much lower colon cancer
rates than native Brits because the turmeric in their curry-flavored
food contains curcumin, which makes it difficult for cancer
to grow and invade healthy tissue.
...
Because this underground stem is rich in phytochemicals, including
beta-carotene (which helps maintain good eyesight),
curcumin
and salicylates, which can be used to relieve numerous ailments,
including nausea, motion sickness and pain and inflammation
...
UPI.com -
May 30, 2011
ANN ARBOR, Mich., May 30 (UPI) -- A compound from the Indian curry
spice curcumin may reduce the needed dosage of head and neck
cancer chemotherapy drugs, US researchers suggest. Senior study
author Thomas Carey of the University of Michigan Medical
...
Food Consumer -
May 25, 2011
Curcumin: In a study of osteoarthritis patients, those who
added 200 mg of curcumin a day to their treatment plan had
reduced pain and increased mobility. A past study also found that a
turmeric extract composed of curcuminoids (plant-based nutrients
...
TestCountry.com -
May 25, 2011
Spice, spice, baby. The main ingredient in turmeric, and Indian
spice, is curcumin. There are studies that indicate that
curcumin has the potential to fight cancer, as it can curb
changes, growth, and invasion of cancerous cells.
The Indian spice turmeric's active ingredient
curcumin helps burn fats and aids digestion by
breaking down protein-rich foods, including detoxifying
the liver. Cinnamon is known to significantly reduce
blood glucose levels and bad cholestrol,
...
HealthJockey.com - May 24, 2011
A South Asian spice called
Curcumin was one of
the strongest protective agents. It also had other
positive heath effects. Hegde commented that the results
from Curcumin are quite beautiful. He specified
that it was very effective in maintaining NEIL
...
Recent studies have suggested that these abilities could
be the result of a transformation in the active compound
in the spice, curcumin, by bacteria found in the
intestinal flora. Turmeric is a bright yellow-coloured
spice that comes from the root of
...
Ahwatukee
Foothills News - May 22, 2011
Eliminate inflammation by choosing an anti-inflammatory
diet and taking natural anti-inflammatories if necessary
such as omega-3 fish oils, ginger,
curcumin,
L-glutamine and proteolytic enzymes. If you're eating
any foods that cause inflammation,
...
They also found the Indian spice
curcumin can
help repair DNA damage from high levels of the elements
that can 'free-float' in the body and cause damage . The
spice binds to the metals, allowing enzymes to repair
damage from reactive oxygen species.
...
Asbestos.com -
May 20, 2011
Curcumin, a derivative of the spice turmeric, has
come into the medical spotlight as a potential agent in
treating mesothelioma. Recent in vitro and in vivo
studies have investigated the turmeric-based compound's
ability to induce apoptosis,
...
DrBicuspid.com -
May 20, 2011
Now researchers at the University of Michigan
Comprehensive Cancer Center have found that a compound
derived from the Indian spice
curcumin can help
cells overcome that resistance (Archives of
Otolaryngology -- Head and Neck Surgery, May 2011, Vol.
...
BioScholar
News - May 20, 2011
Researchers at the University of Michigan Comprehensive
Cancer Center have found that a compound derived from
curcumin helps cells overcome the treatment failure
of head and neck cancer.
Curcumin is the
principal curcuminoid of the popular Indian spice
...
One of the very most effective and potent
natural anti-inflammatory agents is
curcumin, derived from turmeric root.
Turmeric is a yellow spice native to Asia,
widely enjoyed as both a food and a dye.
Turmeric is the yellow in curry powder, and
curcumin
...
The yellow or orange pigment of turmeric,
which is called
curcumin, is even
more potent. Its anti-inflammatory effects
have been shown to be comparable to
prescription drugs. It may provide an
inexpensive, well-tolerated, and effective
treatment for
...
Kessenich held up a small plastic bag
containing the spice tumeric and said a
component of the spice,
curcumin,
fights inflammation. "If we cooked more with
this herb, there would be a lot less
inflammation in our system," he said.
...
Eat. Drink. Better. -
Jeannie Moulton
-
7
May 2011
The same ingredient that gives curry its kick –
curcumin –
may be responsible for helping the body ward of Alzheimer's The
phytochemical curcumin may help
...
|
Barchester Healthcare
-
5 May 2011
"Some research has suggested that caffeine, and various spices and
herbs including curcumin, sage and lemon balm, might have a
protective effect on the ...
|
Live in the Now -
John Phillip
-
3 May
2011
Known as a staple in the Indian diet, the curry spice turmeric and
its powerful polyphenol derivative
curcumin have rapidly
gained attention as a potent ...
|
Food Consumer
-
26 Apr 2011
And unlike aspirin or ibuprofen, turmeric's
curcumin
reduces ... Some research even suggests that
curcumin may also help those suffering asthma,
...
|
Bangkok Post
-
25 Apr 2011
Curcumin, a key component in turmeric, is currently
being evaluated by medical
... Research on
curcumin has revealed it to be a potent antioxidant
that can ...
|
Leicester Mercury -
cathy buss
-
25 Apr 2011
Scientists at the University of Leicester say their research
shows that curcumin, an extract of the root
turmeric, has the ability to kill off cancer cells
...
|
7thSpace Interactive (press release)
-
21 Apr 2011
Docosahexaenoic acid (DHA) and
curcumin (CCM) are
dietary compounds known to antagonize breast cancer cell
proliferation. We report that these compounds in
...
|
7thSpace Interactive (press release)
-
18 Apr 2011
In this study we evaluated the anti-cancer potential of
curcumin in medulloblastoma by testing its ability to
induce apoptosis and inhibit tumor growth in
...
|
The Island.lk
-
15 Apr 2011
By itself,
curcumin - the component in turmeric
most often cited for its healthful effects - is a
multifaceted anti-inflammatory agent, and studies of the
...
|
Scottish Daily Record -
Maria Croce
-
11 Apr 2011
The yellow-orange spice turmeric is packed with
curcumin
which reportedly ... Research says
curcumin
is an anti-inflammatory and antioxidant that's able to
...
|
New York Times -
Kenneth Chang
-
5 Apr 2011
Another compound that was successful in tests was
curcumin, a bright yellow compound
... Because
the dye, like curcumin, binds to the amyloid
proteins, ...
|
Food Consumer
-
4 Apr 2011
Turmeric: Its potent anti-inflammatory properties come from
curcumin
... There are an estimated three to
five grams of curcumin in 100 grams of turmeric.
...
|
San Jose Mercury News -
Richard Halstead
-
3 Apr 2011
One of those is
curcumin, the active ingredient in
the popular Indian spice turmeric. "People have been making
claims about the health benefits of
curcumin
...
|
EurekAlert (press release)
-
3 Apr 2011
Alavez said
curcumin, the active ingredient in the
popular Indian spice ... "People have been making
claims about the health benefits of
curcumin for
many ...
|
-
Christian Post -
Reginald B. Cherry -
Christian Post
-
23
Mar 2011
Meanwhile, herbs such as
Curcumin, or turmeric root, tart
cherry, Holy basil leaf, Boswellia/Indian Frankincense extract have
all been used for centuries as ...
|
-
Technorati -
Hector Corsi
-
22
Mar 2011
Curcumin has been shown to protect normal tissues from
radiation by enhancing ... Recent research published in
Radiation Research also shows that
curcumin
...
|
-
Star Global Tribune -
Matthew Bennett
-
22
Mar 2011
It may also help researchers understand which patients will respond
to therapy with vitamin D3 and
curcumin, a chemical found
in turmeric spice, ...
|
-
Technorati -
John Phillip
-
21
Mar 2011
Curcumin is a potent agent in the fight against colon
cancer, an insidious form of the disease that ranks second among
cancer deaths taking the lives of
...
|
-
Food Consumer
-
18 Mar 2011
The researchers reported in the Journal of Alzheimer's Disease that
vitamin D3 and curcumin both of which repviosu studies by
the same team can help ...
|
-
Live in the Now -
Gale Maleskey
-
18
Mar 2011
Curcumin, a component of turmeric, has liver-protecting
properties similar to ... Several studies have shown that
curcumin can help protect the liver from
...
|
-
Sify
-
18 Mar 2011
It may also help researchers understand which patients will respond
to therapy with vitamin D3 and
curcumin, a chemical found
in turmeric spice, ...
|
-
Patch.com -
ChrisAnn Brunsmann
-
12 Mar 2011
Curcumin is the active ingredient in turmeric, giving it
its strong flavor, rich color and amazing therapeutic benefits. Wow,
what a list! ...
|
-
FitSugar.com -
Heather Dale
-
10
Mar 2011
The active ingredient in turmeric,
curcumin, works in a
very similar way to ... The
curcumin in turmeric is
not only an anti-inflammatory wonder spice,
...
|
-
The Healthier Life
-
9 Mar 2011
A 2007 study showed that
curcumin has the ability to
prevent breast cancer tumour growth
...
Curcumin —
the pigment that gives the curry spice turmeric its
...
|
-
Live in the Now -
John Phillip
-
8
Mar 2011
Curcumin has a long history as an effective weapon in the
fight against ... Derived from curry powder,
curcumin
has been shown to initiate normal cell death
...
|
-
About - News & Issues -
Pam Stephan
-
7
Mar 2011
Curcumin, which occurs naturally in turmeric, can put a
damper on RANKL proteins as well as fight inflammation and cell
oxidation. ...
|
-
Huffington Post (blog)
-
6 Mar 2011
Research has also shown that
Curcumin, the active
ingredient in the common spice, Turmeric, has properties that also
reduce the expression of these deadly
...
|
-
Natural Products Marketplace -
Gene Bruno
-
5 Mar
2011
Studies supporting turmeric's effectiveness attribute its
health-promoting properties to the primary, active curcuminoid
compounds, predominantly curcumin.
...
|
-
Wonder Woman
-
4 Mar 2011
A drug based on
curcumin, a chemical found in turmeric -
can help ...
Curcumin has been studied for its
potential to treat brain injury and disease,
...
|
-
Medical News Today (press release)
-
4 Mar 2011
Curcumin increases the anti-cancer and anti-inflammatory
effects of ... The effect of using a
curcumin
concentrate to improve the effects of cancer drugs
...
|
-
UPI.com
- 3 Mar 2011
Dr. Shahar Lev-Ari of Tel Aviv University's School of Public Health
at the Sackler Faculty of Medicine and colleagues found that
curcumin -- turmeric's
...
|
-
Green Prophet
-
3 Mar 2011
Dov Lichtenberg at the university's School of Public Health, show
that curcumin, the active principle in turmeric, inhibits
the COX-2 enzyme. ...
|
-
Times of India
-
2 Mar 2011
Tel Aviv University researchers have discovered that turmeric's
active ingredient called curcumin amplifies the therapeutic
activity of highly toxic ...
|
-
Natural News.com -
Tony Isaacs
- 1 Mar 2011
*Take lots of the inexpensive spice turmeric, which contains the
cancer fighting adaptogen curcumin.
Curcumin is
also a very good natural anti-inflammatory.
...
|
-
PhysOrg.com
-
1 Mar 2011
Curcumin increases the anti-cancer and anti-inflammatory
effects of ... The effect of using a
curcumin
concentrate to improve the effects of cancer drugs
...
|
-
Huffington Post (blog)
-
25 Feb 2011
Men: skip the PSA test, Google "curcumin prostate cancer"
and read. Eat yellow curry, particularly with crucifers (like the
yellow cauliflower in Indian ...
|
-
Technorati -
John Phillip
-
23
Feb 2011
Curcumin is the active component of the Indian spice,
tumeric that gives curry its deep yellow color. This potent
antiviral is known to provide critical
...
|
-
Natural News.com -
David Jockers
-
22
Feb 2011
The principal crucuminoid is
curcumin which is responsible
for much of the health ...
Curcumin has been shown
to stabilize blood sugar and reverse cellular
...
|
-
Natural Products INSIDER -
Sandy Almendarez
-
22 Feb 2011
Curcumin, the principal curcuminoid of the popular Indian
spice turmeric, is adding zest to bone health products as studies
have shown it can prevent bone ...
|
-
Irish Times -
Claire O'Connell
-
21 Feb 2011
“Evidence suggests
curcumin may regulate lipid metabolism,
which plays a central ... They go on to list various animal
studies that suggest curcumin can
...
|
-
The National -
Erin Conroy
-
18 Feb
2011
His team has found that
curcumin, the major yellow pigment
extracted from turmeric, generates enzyme activities that suppress
tumors. ...
|
-
The Myeloma Beacon -
Howard Chang
-
14
Feb 2011
Phase 2 Study Will Examine
Curcumin's Ability To Reduce
Myeloma Symptoms During Maintenance Therapy – MD Anderson Cancer
Center in Houston will begin a ...
|
-
Food Consumer
-
11 Feb 2011
There are over 100 different pathways that
curcumin has an
effect on once it gets ... Interestingly this also includes
the metabolite of curcumin and its
...
|
-
Firedoglake
-
10 Feb 2011
This member of the ginger family has a substance in the tubers,
curcumin,
... Scientists, using
curcumin, have
developed a drug which helps protect and
...
|
-
Manufacturing Digital -
Rebecca D'Souza
-
9
Feb 2011
US researchers at the Cedars-Sinai Medical Centre in Los Angeles
have found that curcumin, a chemical component of turmeric,
could help aid the recovery of ...
|
-
Toronto Sun
-
8 Feb 2011
The researchers found the new molecule, called
curcumin-hybrid
compound ... This isn't the first time scientists have touted
the healing powers of curcumin.
...
|
-
Serious Injury Law
-
7 Feb 2011
Researchers at the Cedars-Sinai Medical Centre in Los Angeles found
that curcumin, a component of the spice, could be used to
create a new molecule to ...
|
-
Natural News.com -
James Chappell
-
6
Feb 2011
Curcumin is known for its anti-tumor, antioxidant, anti-amyloid
(Alzheimer's) and anti-inflammatory properties. Its anti-cancer
effects stem from its ...
|
-
Insidermedicine
-
5 Feb 2011
A novel hybrid therapy based on the turmeric extract
curcumin
is showing promise in animals studies for the prevention of
neurological deficits associated ...
|
-
CalorieLab Calorie Counter News
-
4 Feb 2011
A hybrid compound made of tumeric and
curcumin given to
rabbits within a hour of a stroke, comparable to 3 hours post-stroke
in humans, reduces motor ...
|
-
Teatro Naturale
-
1 Feb, 2011
And turmeric contains something called “curcumin.”
Curcumin has well-known medicinal properties. It has been
hailed as a champion for its ability to protect
...
|
-
Lexington Herald Leader -
1 Feb, 2011
Their recipe for
curcumin scramble praises
curcumin's
anti-inflammatory ... Home-generated ideas — such as
curcumin — are also generating excitement among
...
|
-
Globe and Mail -
Wency Leung
-
26 Jan
2011
... of Texas's MD Anderson Cancer Center , began studying the
cancer-fighting properties of
curcumin – the active
ingredient in turmeric – in the 1990s.
...
|
-
Coffetoday
-
23 Jan 2011
Research at the University of Texas found that
Curcumin
(the active compound in turmeric) inhibits the growth of skin cancer
cells and slow the spread of ...
|
-
ABC15.com (KNXV-TV) -
Kimberly Kapilovic
-
21 Jan 2011
Efficacy and safety of Meriva, a
curcumin-phosphatidylcholine
complex, ...
Curcumin is the active pigmented
compound that gives the spice turmeric its
...
|
-
Serious Injury Law
-
19 Jan 2011
Researchers from the Medical College of Georgia (MCG) found that
analogues of curcumin and the dye brilliant blue G could
possibly be used to block ...
|
-
Medical News Today
-
19 Jan 2011
Medical College of Georgia researchers suspect that one day
curcumin - the
... And, that
curcumin can block
NF-KappaB's ability to bind to aquaporin-4 and
...
|
-
NutraIngredients.com -
Stephen Daniells
-
14 Jan 2011
Daily supplements containing a mixture of
curcumin with soy
phospholipids may relieve pain and increase mobility in
...
|
-
Nutrition horizon (press release)
-
12 Jan 2011
1/12/2011 --- In a new study from Italian researchers published in
Alternative Medicine Review Meriva, an Indena proprietary
formulation of curcumin with
...
|
-
The Hindu
-
11 Jan 2011
Photo: V. Ganesan
Curcumin, pepper, ginger, garlic have
found their way into ... Orally administering 12 grams per
day for three months, curcumin was found
...
|
-
TheMedGuru
-
8 Jan 2011
Laboratory research on animals suggests that
curcumin (a
derivative of the spice turmeric) has potent anticancer properties.
Now, researchers have launched ...
|
-
MedIndia
-
8 Jan 2011
He has been involved in the research on
curcumin, for which
human trials are on, following the success of animal trials.
According to information available
...
|
-
Times of India -
Pushpa Narayan
-
6
Jan 2011
While research on
curcumin (a derivative of turmeric) is in
the human trial stage, animal trials on others have shown promising
results, scientists said at ...
|
-
The Myeloma Beacon -
Pat Killingsworth
-
6 Jan 2011
However, one anti-myeloma supplement appears to stand head and
shoulders above the rest: Curcumin.
Curcumin is an
extract of turmeric, a spice widely used
...
|
-
Natural Products Marketplace -
Chris Kilham
-
6 Jan
2011
Conversely, various studies on
curcumin, an agent found in
common turmeric root, ... If bound to fats,
curcumin
also works almost as quickly. ...
|
-
NOW Toronto -
Elizabeth Bromstein
-
5 Jan 2011
It contains the compound
curcumin, which is said to do all
kinds of wonderful things, ... No one has found a cancer
which is not attacked by curcumin.
...
|
-
ProHealth -
Mona E-Azab
-
5 Jan
2011
The phytochemicals resveratrol or
curcumin have been shown
to possess many ... Individual treatments with resveratrol or
curcumin and their combination with
...
|
-
Fox News -
Chris Kilham
-
6 Dec
2010
As relates to turmeric, science has investigated this humble root
and has discovered in it a powerful compound called
curcumin.
This simple material has the ...
|
-
LiverSupport.com -
Nicole Cutler
-
1
Dec 2010
New research demonstrates that a compound in curry could help in the
management of chronic liver disease. by Nicole Cutler, L.Ac.
Curcumin is found in the
...
|
-
-
msnbc.com -
Emily Sohn
-
29 Nov
2010
The researchers drew inspiration from a group of well-studied
chemicals made by some plants, including resveratrol in grapes,
curcumin in turmeric,
...
|
-
Natural Products Marketplace
-
29 Nov 2010
One such nutritional ingredient is
curcumin, the primary
active compound in turmeric. Lemerond noted it is primarily known as
a strong anti-inflammatory and ...
|
-
Zee News
-
26 Nov 2010
Chen's work has tested the effect of
curcumin on the role
of high levels of ... The researchers found that among other
activities, curcumin eliminated the
...
|
-
MedIndia (blog)
-
26 Nov 2010
Curcuminoids like
curcumin, demethoxycurcumin acts as
inflammatory in Osteoarthritis and rheumatoid arthritis. Local
application in Small pox, ...
|
-
Jewish Chronicle -
Ruth Joseph
-
23 Nov
2010
The reason for this is the compound
curcumin, a wonderful
antioxidant and anti-inflammatory which works in the same way as
over-the-counter ...
|
-
ProHealth -
Karen Lee Richards
-
19 Nov 2010
Curcumin, the primary component of the spice turmeric, has
been employed ... More recently, Western scientists have
begun taking a closer look at
curcumin.
...
|
Daily 49er
-
17
Nov 2010
In such locations, the concentration of the antioxidant
curcumin,
...
Curcumin's chemically rich makeup depletes after the
liver metabolizes its content.
...
-
Some of these trials are studying the effects of
curcumin
on colon cancer, ... The only downside to
curcumin,
it seems, is its poor bioavailability
...
|
-
pharmabiz.com -
Nandita Vijay
-
12
Nov 2010
The Department of Biotechnology (DBT) funded phase 1 study of the
combination drug artesunate+curcumin combination for
Plasmodium falciparum malaria will be
...
|
-
Del Mar Times -
Peggy Korody
-
9 Nov
2010
They are finding that by combining black pepper, and
curcumin
(the main ingredient in the curry spice turmeric) with breast cancer
cells in a laboratory ...
|
-
NewsMax.com
-
8 Nov 2010
Turmeric, also known as Curcuma Longa, contains a pigment called
curcumin that acts as an excellent, natural glaucoma treatment
because of its ...
|
-
Everything Long Beach (press release)
-
7 Nov 2010
... is among scientists who are examining a promising
correlation between lifetime consumption of
curcumin, a
bioflavonoid found in the curry spice turmeric
...
|
-
Pulse
-
5 Nov 2010
Provocative in vitro and animal studies regarding the role of
turmeric (containing the active ingredient
curcumin) in the
treatment and prevention of ...
|
-
Arab News -
Mariam Alireza
-
3
Nov 2010
Turmeric,
curcumin, produces anti-inflammatory and
pain-soothing effects. It can be taken as an herb, spice in food, or
supplement. ...
|
-
Independent
-
3 Nov 2010
A new study discovered that a compound found in turmeric called
curcumin may play a vital role in liver health. Announced in an
October 29 release, ...
|
-
UroToday
-
3 Nov 2010
Recently we have reported that
curcumin inhibits the
expression of androgen receptor in prostate cancer in vivo and in
vitro. (Ide et al. Prostate 2010.
...
|
-
UPI.com
-
2 Nov 2010
2 (UPI) --
Curcumin -- a chemical found in the spice
turmeric -- may help slow damage from fatty liver disease, US
researchers say. ...
|
-
Fox News -
Chris Kilham
-
2 Nov
2010
In studies of a primary ingredient in turmeric called
curcumin,
researchers have found that the development of beta-amyloid plaque
can be inhibited. ...
|
-
Allentown Morning Call -
Alisa Bowman
-
2 Nov
2010
The chemical
curcumin is found in turmeric, which is used
to make curry. ... Researchers from St. Louis Univeristy
found that curcumin protected liver cells
...
|
-
Minot Daily News -
Emily Listfield
-
2
Nov 2010
Studies by the University of Arizona College of Medicine show that
curcumin, the active ingredient in this Indian spice, helps
prevent joint inflammation ...
|
-
San Mateo Daily Journal -
Paulette Millis
-
2
Nov 2010
Use herbs and spices like turmeric, cinnamon, licorice root,
curcumin and artichoke. • Use supplements to enhance liver
function, such as alpha lipoic acid,
...
|
-
Huffington Post (blog)
-
2 Nov 2010
The gene that turns on BDNF is activated by a variety of factors
including physical exercise, caloric restriction,
curcumin
and the omega-3 fat, DHA. ...
|
-
Jackson Clarion Ledger
-
1 Nov 2010
New research suggests that regular use of
curcumin, the
active ingredient in turmeric, could have a significant impact on
other medications (Annals of ...
|
-
Natural News.com -
Celeste Smucker
-
1
Nov 2010
For example, consider herbs from India's ancient Ayurvedic tradition
such as curcumin, boswellia and holy basil. All of these
have powerful ...
|
-
Bizjournals.com (blog) -
Kelsey Volkmann
-
1
Nov 2010
Well, maybe not exactly, but a Saint Louis University researcher has
found that curcumin, the spice found in curry, holds
promise in preventing or treating
...
|
-
Medical Daily
-
31 Oct 2010
Curcumin, a chemical in turmeric can treat the
non-alcoholic ...
Curcumin eliminated the effects of
leptin, which plays a crucial role in the development of
...
|
-
Ode Magazine
-
30 Oct 2010
I almost performed 200 beck bends for the first 2 months, with lots
of icing, and taking turmeric
curcumin pills. Turmeric is
an ancient natural anti ...
|
-
TheMedGuru
-
30 Oct 2010
"While research in an animal model and human clinical trials are
needed, our study suggests that
curcumin may be an
effective therapy to treat and prevent
...
|
-
infocera
-
30 Oct 2010
The chemical
curcumin contained in turmeric has properties
which can help in treatment ...
Curcumin has effects
on leptin, a hormone play a key role in fat
...
|
-
TopNews -
Piyush Diwan
-
30
Oct 2010
Curcumin, the chemical is placed in turmeric, a plant
utilized by the Chinese to design established medicines for many
thousands of years. ...
|
-
The Hindu
-
30 Oct 2010
Chen's work has tested the effect of
curcumin on the role
of high levels of ... The researchers found that among other
activities, curcumin eliminated the
...
|
-
Softpedia
-
30 Oct 2010
Saint Louis University researchers carried out a study exploring the
healing properties of curcumin, a chemical from Turmeric
(Curcuma), and found that it ...
|
-
The Epoch Times -
Michael Dabney
-
29
Oct 2010
Curcumin is derived from the root of the turmeric plant.
... Studies have shown that the chemical
curcumin is
capable of blocking a biological pathway that
...
|
-
eMaxHealth -
Deborah Mitchell
-
29 Oct 2010
Scientists are suggesting that
curcumin, the poignant
chemical in turmeric that gives curried dishes their punch, may help
prevent or treat liver damage ...
|
-
CalorieLab Calorie Counter News
-
29 Oct 2010
New research from Saint Louis U shows the spice
curcumin
might be beneficial in preventing or treating livers damaged from a
form of fatty liver disease. ...
|
-
Lexington Minuteman -
Stan Goldin
-
28 Oct
2010
For certain “anticancer agents” or preventives (eg garlic[2],
curcumin, and bilberry) there may be animal data and (in some
cases) human studies, ...
|
-
Examiner.com
-
28 Oct 2010
A study found that
curcumin which is in turmeric is
effective in the removal of plaque from the brain. Apples in which
contain quercetin in their peels have
...
|
-
Natural Products Marketplace
-
27 Oct 2010
Two studies at the University of Colorado are currently researching
vitamin D and curcumin, according to Colorado Daily, and
similar projects that test ...
|
-
Daily Camera -
Whitney Bryen
-
26
Oct 2010
There are two studies underway looking at the effects of Vitamin D
and Curcumin -- the major component of the India spice
turmeric, used in curry. ...
|
-
EndocrineWeb
-
26 Oct 2010
The team wanted to combine
curcumin with the
chemotherapeutic drug ... The study found that
curcumin
suppressed head and neck cancer growth and did not have
...
|
-
Mid-Day
-
25 Oct 2010
Curcumin has been found to help curb the growth of breast,
...
Curcumin is believed to work by suppressing a
protein that controls cell growth.
...
|
-
WSFA
-
25 Oct 2010
She is trying to mix traditional therapy with the Indian spice,
Curcumin. Incorporating natural therapies like
Curcumin
to treat cancer can lead to less ...
|
-
Central Florida News 13
-
24 Oct 2010
Muna Oli has spent the past five years combining traditional and
alternative medicine, particularly the Indian spice
curcumin.
She said she believes the ...
|
-
Indian Express
-
23 Oct 2010
Researchers have found that
curcumin, the major component
in the spice turmeric, when combined with the drug cisplatin,
enhances chemotherapy's suppression
...
|
-
NutraIngredients-usa.com -
Nathan Gray
-
22 Oct
2010
Curcumin complex may reduce relapses of recurrent anterior
uveitis by over 80 percent, according to new research.
...
|
-
Bioidentical Hormone Health -
Pauline Manning
-
21
Oct 2010
There are an number of anti-inflammatory herbs such as Boswellia,
Ginger and Curcumin which can relieve the symptoms. Omega 3
Fish Oil is anti-inflammatory ...
|
-
NewsMax.com
-
21 Oct 2010
Curcumin, a compound in turmeric, and garlic are used as
natural supplements for multiple sclerosis. 9. Herbal medicines (Bushen
Gusui) and medical cannabis ...
|
-
Lexington Minuteman -
Michael Phillis
-
21
Oct 2010
To rebalance the body's Type 2 cells, Belanger uses natural remedies
such as curcumin, theaflavin, bilberry, and garlic.
Belanger treats a variety of ...
|
-
eMaxHealth -
Kathleen Blanchard
-
21 Oct 2010
Researchers have found that
curcumin from the Indian spice
turmeric suppresses cancer of the head and neck when combined with
chemotherapy. ...
|
-
TheMedGuru
-
21 Oct 2010
The active constituents of turmeric are considered to be turmerone
oil and water soluble curcuminoids, including
curcumin.
Studies show that the compound ...
|
-
UPI.com
-
20 Oct 2010
LOS ANGELES, Oct. 20 (UPI) --
Curcumin, found in the spice
turmeric, enhances the head and neck cancer drug Cisplatin by
suppressing cancer cell growth, ...
|
-
Times of India
-
20 Oct 2010
Researchers with UCLA's Jonsson Cancer Center have found that
curcumin, the major component in the spice turmeric, when
combined with the drug Cisplatin ...
|
-
The News International
-
19 Oct 2010
Tip:
Curcumin is the leading compound found in turmeric,
which in turn is a key ingredient in curry powder. Turmeric is
extremely pungent, and actually gets
...
|
-
Examiner.com
-
19 Oct 2010
For the past six years, two researchers at the UCLA Jonsson Cancer
Center have been studying the anti-cancer properties of
curcumin,
which is the major ...
|
-
PressZoom (press release)
-
19 Oct 2010
Curcumin, the active ingredient in the curry spice
turmeric, ... Recent investigations on
curcumin have
shown powerful anti-inflammatory effects in other
...
|
-
New University Online -
Gregory Yee -
Suzanne Casazza
-
19
Oct 2010
Mahtab Jafari, associate professor of pharmaceutical sciences at UC
Irvine, and Korean researcher Kyung-Jin Min, discovered that
curcumin, the active
...
|
-
MedPage Today -
Kristina Fiore
-
19
Oct 2010
Curcumin -- the active ingredient in the spice turmeric --
inhibited the growth of ... It also showed that the active
ingredient curcumin is a hydrophobic
...
|
-
RedOrbit
-
19 Oct 2010
In the study, "Inhibiting Hospital Associated Infection of Toxigenic
Clostridium difficile Using Natural Spice – Turmeric (Curcumin),"
Dr. Patel and his ...
|
-
TREND
-
18 Oct 2010
According to a researcher in University of California, Irvine,
curcumin,
... Dr. Jafari found out that
curcumin
can increase the life span of fruit flies by
...
|
-
Daily Mail -
Pat Hagan
-
18 Oct
2010
Curcumin, a key constituent of the curry spice turmeric,
... Meanwhile, a separate study at the US Salk Institute found
curcumin appeared to protect nerve
...
|
-
Live Trading News
-
18 Oct 2010
Curcumin, a spice that is common in Indian curries and
other Asian dishes, might extend the lifespan of humans because it
is full of anti-oxidants and other
...
|
-
Natural News.com -
Tony Isaacs
-
17 Oct
2010
Among the best are magnesium,
curcumin, oleander extract
and blackseed oil (Nigella sativa). 6) Bromelain, a digestive enzyme
from pineapple stems, ...
|
-
Bernama
-
17 Oct 2010
Curcumin is an ingredient in turmeric, a golden spice that
is a staple in ... The study demonstrates a potential use of
curcumin treatments for mammals,
...
|
-
Zee News
-
October 9, 2010
Previous laboratory research has shown that
curcumin, from
turmeric, has not only improved the effectiveness of chemotherapy
but has also reduced the number ...
|
-
Daily Comet -
Nan Cohen
-
October
7, 2010
“Another thing being investigated is a chemical in tumeric and
cumin, called curcumin, that's thought to have antioxidant
properties,” Schnabel says. ...
|
-
Seer Press
-
October 6, 2010
During the experiment for improving the effectiveness of
chemotherapy and radiation treatment, the scientists used
curcumin – an extract of turmeric root.
...
|
-
Natural Products Industry Insider -
Brenda Porter-Rockwell
-
October 3, 2010
Scientists from University of California Los Angeles School of
Medicine (UCLA) studying curcumin, the principal
curcuminoid found in the spice turmeric,
...
|
-
Live in the Now -
Gale Maleskey
-
October 1, 2010
Curcumin, a component of turmeric, a spice that, like
cinnamon, contains polyphenols that may help regulate blood sugar.
|
-
The News International
-
30 Sep 2010
Researchers at the University of Leicester have been using
curcumin - an extract
... 'Previous laboratory research
has shown that curcumin, from turmeric,
...
|
-
EndoNurse
-
30 Sep 2010
LEICESTER, UK—Researchers at the University of Leicester are
investigating the colorectal cancer-fighting potential of the
curcumin, an extract of the
...
|
-
San Leandro India West
-
30 Sep 2010
... the patients in the second group added the special
curcumin extract, which is difficult to absorb into the human
bloodstream when consumed orally,
...
|
-
Private Healthcare UK
-
30 Sep 2010
Research carried out into the potential benefits of
curcumin,
an extract from the root of the spice, found that it helps to
improve the effectiveness of ...
|
-
Helium -
John Phillip
-
30
Sep 2010
Additional support is provided by the Omega-3 fat DHA, resveratrol,
curcumin and grape seed extract. Lower your risk of
developing Alzheimer's disease by
...
|
-
HealthJockey.com
-
30 Sep 2010
It is known that
curcumin is an extract of the commonly
used root turmeric. ...
Curcumin, from turmeric
boosts the efficiency of chemotherapy and also
...
|
-
Examiner.com
-
30 Sep 2010
Previous studies found that injecting a formula which included
curcumin into
... However, adding
curcumin to
the treatment process lowers the risk of the
...
|
-
TopNews United States -
Satish Karat
-
30
Sep 2010
The researchers at the university's Department of Cancer Studies and
Molecular Medicine will find out the functioning of
curcumin
in restricting the growth ...
|
-
Times of India
-
30 Sep 2010
Researchers at the University of Leicester have been using
curcumin - an extract of
... Previous laboratory
research has shown that curcumin, from turmeric,
...
|
-
Food Product Design
-
29 Sep 2010
LEICESTER, United Kingdom—Researchers at the University of Leicester
are investigating the colorectal cancer-fighting potential of the
curcumin, an extract
...
|
-
Active Quote
-
29 Sep 2010
Scientists from the University of Leicester have discovered that
curcumin - an extract of root turmeric - can improve the
effectiveness of chemotherapy, ...
|
-
Lawrence Journal World (blog) -
Ronda Miller
-
29
Sep 2010
Tumeric: With active ingredient
curcumin, tumeric has been
known for its anti inflammatory properties for centuries, but is now
believed to be beneficial in ...
|
-
Poughkeepsie Journal -
Chandra Balusu
-
29
Sep 2010
The active ingredient in turmeric is
curcumin, a powerful
antioxidant and anti-inflammatory substance, which may help to fight
free radicals. ...
|
-
Personal Liberty Digest
-
28 Sep 2010
... is another important step towards validating the
curcumin in turmeric as an increasingly popular herbal dietary
supplement," said Mark Blumenthal,
...
|
-
Massage Today -
Leon Chaitow
-
28
Sep 2010
(Capello et al 2007) While some studies have shown potential benefit
for use of turmeric (curcumin) in treatment of IBS (a
member of the ginger family of ...
|
-
The Press Association
-
28 Sep 2010
Scientists at the University of Leicester have been using
curcumin - an extract
... The aim is to use
curcumin
to target chemo-resistant cells in colorectal
...
|
-
Natural News.com -
Sl Baker
-
27 Sep
2010
And in recent years, scientists have documented that tumeric and the
natural compound it contains called
curcumin may protect
and heal due to ...
|
-
allvoices -
Debbie Nicholson
-
27 Sep 2010
Chris Kilham, of Fox News "Medicine Hunter" and ethnobotanist,
latest announced spice turmeric root, also referred to as
curcumin when it is in extract form
...
|
-
Business Standard
-
25 Sep 2010
CURCUMIN — Is a strong cold and flu-fighter. Has both
antiviral and antioxidant properties to help the body ward off viral
infections. Source: Turmeric.
|
-
Leicester Mercury -
cathy buss
-
24 Sep
2010
Curcumin, an extract of the root turmeric, has the ability
to kill off cancer cells which are resistant to chemotherapy,
...
|
-
Care2.com -
Michelle Schoffro Cook
-
22 Sep 2010
Additional studies are having similar positive results. The easiest
way to enjoy the benefits of curcumin is by adding turmeric
to your favorite curry dish.
|
-
BETTER Health Research
-
22 Sep 2010
Incorporating
curcumin-based tumeric extract into one's
pain relief regimen may benefit osteoarthritis sufferers, according
to a study by the American ...
|
-
Huffington Post (blog)
-
22 Sep 2010
Have a Curry Meal: A constituent of curry spices known as
curcumin blocks Alzheimer's-like brain damage and boosts memory
in animal and lab tests. ...
|
-
WDUQNews (blog)
-
22 Sep 2010
Curcumin, commonly known as the spice Turmeric has been
shown to have ... So what they're trying to do is find that
000.1 percent of curcumin that would get
...
|
-
Natural News.com -
Tony Isaacs
-
21 Sep
2010
*Curcumin is a powerful immune modulator which has many
health benefits. It is also anti-inflammatory. *Blackseed Oil (Nigella
sativa) is another immune ...
|
-
Natural News.com -
Jonathan Benson
-
21
Sep 2010
Turmeric (curcumin), cinnamon and apples, for instance,
have all been shown in studies to prevent and treat the degenerative
effects of dementia. ...
|
-
healthzone.ca
-
21 Sep 2010
Curcumin has such a stellar track record in labs for
shutting down pancreatic ...
Curcumin is why Dr.
Mike walks around with a mustard packet in his pocket;
...
|
-
PR Newswire (press release)
-
21 Sep 2010
... including DIM, pygeum bark extract, saw palmetto, Vitamin
D-3, green tea, bio-enhanced turmeric root (curcumin),
stinging nettle, among others. ...
|
-
Kingston Reporter -
Chris Reagle
-
20
Sep 2010
Turmeric is especially rich in
curcumin, a compound
believed to inhibit Alzheimer's disease in multiple ways, according
to experts at the University of ...
|
-
ChicagoNow (blog)
-
19 Sep 2010
Turmeric: This powerful Asian spice contains a natural
anti-inflammatory compound, curcumin, which is often found
in curry blends. ...
|
ChicagoNow (blog)
|
-
The Hindu
-
18 Sep 2010
Pomegranate, green tea, fish and
curcumin could also act as
anti-amyloid agents, he said. Amyloids are to AD as cholesterol is
to heart disease. ...
|
The Hindu
|
-
StarCityNews.com
-
17 Sep 2010
Though the current research focuses on
curcumin, the entire
group of spices usually included in curry powder have been touted
for centuries as being good ...
|
-
Wiki Peers -
Anshu Dubey
-
17 Sep
2010
Ayurveda suggests that turmeric has
Curcumin as an active
component, which help you in switching off certain genes that lead
to scarring and heart ...
|
-
Huffington Post
-
17 Sep 2010
"Relation of structure of
curcumin analogs to their
potencies as inducers of Phase 2 detoxification enzymes."
Dinkova-Kostova AT, Talalay P. 21) Alcohol.
...
|
-
Natural News.com -
Ethan A. Huff
-
16
Sep 2010
And according to Chris Kilham, an ethnobotanist and Fox News'
"Medicine Hunter", turmeric root -- also known in its extract form
as curcumin -- is one such
...
|
-
The Express Times - LehighValleyLive.com
-
16 Sep 2010
Turmeric also contains
curcumin, which acts as an
anti-inflammatory compound without the toxic chemicals present in
commercial products, according to
...
|
-
Star Global Tribune -
Matthew Bennett
-
16
Sep 2010
The characteristic yellow color of turmeric has been attributed to a
compound known as curcumin, which belongs to a group of
compounds which are ...
|
-
Times of India -
Eisha Sarkar
-
16
Sep 2010
Here are 12 foods that can help you lose weight and gain health:
Turmeric : Curcumin, the active component of turmeric, is
an object of research owing to ...
|
-
7thSpace Interactive (press release)
-
14 Sep 2010
Here, we report on the anti-proliferative, anti-migratory, and
anti-invasive properties of the natural, nontoxic compound
Curcumin observed in five human
...
|
-
Chicago Flame Online (subscription)
-
12 Sep 2010
If a more natural treatment is desired, Jacob Teitelbaum, MD, author
of Pain Free 1-2-3 suggests boswellia, willow bark, and
curcumin-based
supplements, ...
|
-
St. Louis Globe-Democrat -
Cheryl Shea
-
6
September, 2010
Some natural compounds that can be incorporated into your daily life
include curcumin (turmeric) garlic, and green tea. These
have all been shown to reduce ...
|
-
NutraIngredients.com -
Shane Starling
-
5
September, 2010
.. elderberry juice; glutathion; aged garlic; rooibos;
ginseng; ginkgo biloba; cherries; echinacea ; bilberry ;
curcumin and capsicum.
...
|
-
The Myeloma Beacon -
Francie Diep
-
4
September, 2010
Curcumin, a compound found in the spice turmeric, may work
to kill myeloma cells and prevent them from multiplying. For those
who have the pre-cancer ...
|
-
Medical News Today (press release)
-
2 September, 2010
"Preliminary research has shown that ginger,
curcumin and
coenzyme Q10 have been effective treatments for some patients. Going
forward we are looking at a ...
|
-
Natural News.com -
Melanie Grimes
-
1
September, 2010
The active ingredient in turmeric, known as
curcumin, helps
heal the sinus cavity. The herb turmeric has been used in Indian
cuisine, Ayurvedic Indian ...
|
-
Natural News.com -
Maddie Ellison
-
28
Aug 2010
Nagabhushan went on to say that his studies showed that the
principle coloring agent in turmeric,
curcumin, mitigated
the effects of some of the risk ...
|
-
UA News (press release) -
Darci Slaten
-
27
Aug 2010
UA Steele Center researchers are investigating how
curcumin
– the biologically active ingredient in turmeric, used in curry –
aids in treating Inflammatory ...
|
-
Arizona Daily Star (blog)
-
25 Aug 2010
The researchers have previously shown
curcumin decreases
severe inflammation in the ...
Curcumin is the
biologically active ingredient in turmeric – the key
...
|
-
Online Athens
-
23 Aug 2010
After two frustrating years, I made an ointment by mixing pure
curcumin powder in Vaseline.
...
Curcumin pills
now keep her condition under control.
...
|
-
The Freeport News
-
23 Aug 2010
Tumeric extract (curcumin) is a spice that is also very
beneficial for heart- burn. All of the above are very good for
addressing food fears. ...
|
-
Richmond Times Dispatch -
Joe Graedon -
Teresa Graedon
-
21
Aug 2010
After two frustrating years, I made an ointment by mixing pure
curcumin powder in Vaseline.
...
Curcumin pills
now keep her condition under control.
...
|
Brattleboro Reformer -
Aug 20, 2010
There are many testimonials on the benefits of the yellow
spice turmeric or its active ingredient
curcumin
...
7thSpace Interactive (press
release) - Aug 20, 2010
Curcumin down-regulated all the survival signals induced by
nicotine in both the cells, irrespective of their p53 status. The
hypothesis was confirmed when ...
The active ingredient in turmeric is called
curcumin. Modern
research has shown curcumin to have antibiotic, antiviral,
anti-inflammatory, and antioxidant
...
Colorado State University
News (press release) - Aug 18, 2010
The
curcumin in turmeric, the primary ingredient in curry
powder, has been shown to reduce the risk of developing diabetes in
obese mice. ...
UroToday -
Aug 18, 2010
Curcumin, a dietary yellow pigment of Curcuma longa, has
emerged as having a chemopreventive role. Although
curcumin
has been shown to inhibit AR expression
...
Associated Content -
Aug 17, 2010
This article reports on a recent study that found that
curcumin
in the curry spice turmeric begins killing throat cancer cells
within 24 hours. ...
7thSpace Interactive (press
release) - Aug 16, 2010
A novel small molecular STAT3 inhibitor, FLLL32 was specifically
designed from dietary agent, curcumin to inhibit constitutive
STAT3 signaling in multiple ...
Metro Canada - Edmonton -
Aug 15, 2010
The fact it is rich in phytochemicals, including gingerols,
beta-carotene, curcumin and caffeic acid, is a strong base
for its therapeutic qualities. ...
Sun-Sentinel - Aug 4,
2010
Curcumin. Found in the spice turmeric, it
reduces blood sugar and chases away pain-causing
TNF and nitric oxide. Cook with turmeric spice,
but also take a ...
Trinidad
News - Aug 4, 2010
According to researchers at the University of
California, Los Angeles, a chemical found in the
spice called curcumin can reduce the
build up of knots in the
...
-
Victoria
Advocate - Jul 31, 2010
Somasundaram began studying the biological
effects of curcumin in 1988 and has since
learned that a diet rich in the spice
temporarily delays the
...
fnbnews.com - Jul 29,
2010
Giving an example of the traditional
curcumin
consumption habit among Indians, he said that
researchers had found that
curcumin
reduces Alzheimer and
...
Curcumin, an extract of turmeric, which
curry powder is largely composed of, has
received lots of modern scientific attention and
its effect on diseases and
...
Natural
Products Industry Insider -
Jul 27, 2010
MILAN, Italy—Scientists have found a proprietary
curcumin extract may relieve pain and
increase mobility in osteoarthritis (OA)
patients at a dose much
...
Oklahoma Medical Research Foundation
scientist Biji Kurien is studying how
curcumin, a chemical present in
turmeric spice, can affect cancer.
...
Preclinical studies also indicate
curcumin (the active ingredient
in turmeric) has potent chemoprotective actions against a variety of
tumors. ...
Justmeans - Jul 4, 2010
... Carrot, Chlorophyll,
Curcumin, Elderberry, Grape,
Hibiscus, Paprika, Red Cabbage, Spinach, and Turmeric among others, but
they are expensive to use, ...
Natural Products Industry Insider -
Jul 2, 2010
Atop Qureshi's list of key botanicals is turmeric (Curcuma longa); its
active ingredient curcumin has been studied for its
anti-inflammatory and antioxidant ...
In the 18 genetically modified mice, detection of plaques followed
administration of curcumin, a plaque-labeling fluorochrome. The
researchers found that ...
Studies show that turmeric and its principal active ingredient,
curcumin, possess many anti-cancer properties. This spice has shown
to inhibit tumour cell ...
7thSpace Interactive (press release) -
Jul 1, 2010
Curcumin is a phytochemical capable of inhibiting IL-1beta-induced
activation of NF-kappaB and expression of apoptotic and pro-inflammatory
genes in ...
Curcumin, which is present in the Indian curry spice turmeric, is
also known to have potent anti-inflammatory properties, and has also been
the subject of ...
I am a retired physician and an emeritus professor of medicine. I also
have Alzheimer's disease. ...
Curcumin, a natural component of the spice turmeric, was used to
label and detect plaque in the retinas. The
curcumin attaches
itself to amyloid plaques and ...
7thSpace Interactive (press release) - Jun
25, 2010
We characterized the biologic effects of a novel small molecule
STAT3 pathway inhibitor that is derived from the natural product
curcumin.
...
Natural Products Marketplace -
Chris
Kilham - Jun 21,
2010
Compounds in turmeric most responsible for its broad uses are the
bright, yellow curcuminoids, notably
curcumin, which makes up
about 3 percent of the ...
UroToday - Jun
20, 2010
Isoflavones and
curcumin have anti-inflammatory and
anti-oxidant properties. We examined the biological effects of soy
isoflavones and curcumin on LNCaP
...
ABC Online - Jun
20, 2010
Scientists from Adelaide's Centre for Stem Cell Research have found
that curcumin extracted from turmeric stops cells from dying
in the donated organ and ...
*Curcumin, the yellow compound found in turmeric, is getting
increasing attention and may be a good preventive. *Natural
supplementation with huperzine may
...
Curcumin is an oil found in turmeric. Research has shown that
in animals curcumin enhances the activity of an enzyme that
might prevent or slow the ...
Research conducted at UCLA, published in the Journal of Biological
Chemistry (December 2004), establishes the mechanisms behind
Curcumin's
protective ...
For his research project, Kelly studied the application of
curcumin,
a component of the spice turmeric, as an effective treatment for
cancer.
FreshPlaza - Jun
16, 2010
A study published in Gut, a publication of the British Medical
Journal, found that the compound curcumin found in turmeric,
is a powerful anti-inflammatory ...
About - News & Issues (blog) - Jun
16, 2010
... people with conditions marked by musculoskeletal tension
(such as TMJ syndrome). In addition,
curcumin may help lessen
pain associated with tendonitis.
Food Consumer - Jun
15, 2010
It appears that
curcumin -- the pigment that gives turmeric
its yellow-orange color -- is responsible for many of turmeric's
medicinal effects, ...
As well as relieving IBS, protecting the liver and improving the
digestion of fats, curcumin, an active component in turmeric,
has been shown to have ...
PakTribune.com - Jun
11, 2010
Tests in mice showed that
curcumin, an active compound found
in turmeric, helped stop the spread of breast cancer tumor cells to
the lungs. ...
Devil's claw has demonstrated efficacy in the management of low back
pain Curcumin is the active anti-inflammatory agent found in
the spice turmeric. ...
About - News & Issues (blog) - Jun
9, 2010
A key component of turmeric is
curcumin, which has long been
used medicinally in the east and has been studied in the west.
Especially when you consider ...
-
eMaxHealth -
Deborah
Mitchell -
June
7, 2010
A University of Illinois study, for example, noted
that flaxseed may reduce the severity of the disease, while
another research project found that
curcumin
...
|
-
KXLY Spokane
-
June
6, 2010
Studies show that
curcumin works as
an antioxidant, anti-inflammatory, antiviral, antibacterial,
antifungal and anticancer power. Leafy herbs, such as mint,
...
|
-
Great Falls Tribune -
Amy
Grisak -
June 5,
2010
The
curcumin, the chemical found in
curry, and turmeric, which gives it its distinct yellow color,
helps keep the brain free of mind-clogging plaques.
...
|
-
7thSpace Interactive (press release)
-
June 4, 2010
Curcumin, an active principle
component in rhizome of Curcuma longa, has proved its merit for
diabetes through its anti-oxidative and anti-inflammatory
...
|
-
Newcastle Herald (blog) -
Jeff
Corbett -
June
3, 2010
The gingerols and
curcumin etc will
be assisting but cancer cells have on their membranes proteins
that have similar peptide groups to the foods we cannot
...
|
-
The Hindu
-
June
2, 2010
Vashi said that yield and
curcumin content
of the NAU Turmeric 1 was better than
... Also the
curcumin,
content which determines the quality of turmeric,
...
|
-
Deccan Chronicle
-
June
1, 2010
Tumeric contains an active phytochemical called
curcumin
and an essential oil, both of which are excellent for relieving
all kinds of disorders. ...
|
-
NewsReleaseWire.com (press release)
-
May 26, 2010
Curcumin is the yellow pigment
derived from the spice tumeric. Fine quality dietary supplements
standardize curcumin for the amount of curcuminoids,
...
|
-
Scientific American -
Gary
Stix -
May 26,
2010
As such, the rodents, she thinks, might prove ideal
in testing the potential for prevention of a cocktail of natural
compounds—from curcumin (an ingredient
...
|
-
PR Web (press release)
-
May 26, 2010
Both capsaicin and
curcumin have
demonstrated promising results in recent
... This
supplement contains both capsaicin and
curcumin in
quantities based on ...
|
-
Chicago Sun-Times
-
May
19, 2010
Six times a week, have a little
curcumin
(a spice used in curry and many mustards). And keep mentally
active by reading books, doing brain-teaser games or
...
|
-
Truth In Aging (blog)
-
May 17, 2010
Curcumin is thought to be the primary
pharmacological agent in turmeric.
... However, in some
studies, curcumin's anti-inflammatory effects have been
shown ...
|
-
That's Fit -
Joe
Dowdell -
May
12, 2010
--Curcumin: 800 mg 1 to 3 times daily (the
antioxidant in turmeric, ... *Use caution with Resveratrol,
Curcumin and Grapeseed supplements if you have an
...
|
-
San Mateo Daily Journal -
Lisa
Tsakos -
May 12,
2010
The spice turmeric contains the powerful, non-toxic
compound curcumin. Studies have found that turmeric's
anti-inflammatory effects are as effective as
...
|
-
Gospel Herald -
Reginald
B. Cherry -
May
11, 2010
Turmeric contains
curcumin and
curcuminoids, which are powerful anti-inflammatory phytochemicals
that act as natural COX-2 inhibitors in the body,
...
|
-
Success Magazine
-
May
11, 2010
You'll come across ingredients like turmeric (and
curcumin,
spices found in Indian and curried foods; mustard also contains
turmeric) and nutrients like ...
|
-
Truth In Aging (blog)
-
May 10, 2010
An unusual ingredient for a hair product is
turmeric, but it makes sense given that its key component is
curcumin,
an anti-inflammatory that may be able to
...
|
-
Natural Products Marketplace
-
May 10, 2010
Its active compound,
curcumin, has been
shown to bind to beta-amyloid, stopping the accumulation of
hardened fragments and promoting the destruction of
...
|
-
Christian Post -
Reginald
B. Cherry -
Christian
Post -
May 10,
2010
Turmeric contains
curcumin and
curcuminoids, which are powerful anti-inflammatory phytochemicals
that act as natural COX-2 inhibitors in the body,
...
|
-
Foster's Daily Democrat
-
May 8, 2010
Add curry powder - the
curcumin in curry
inhibits the ody's production of prostaglandin E 2, an
inflammatory compund that over-sensitizes nerves.
...
|
-
eMaxHealth -
Kathleen
Blanchard -
May
4, 2010
Ovarian cancer cells pretreated with
curcumin
become more vulnerable to chemotherapy, found by researchers from
Sanford Research and the University of South
...
|
-
TheMedGuru -
Neha
Jindal -
Apr 30,
2010
“Herein, we demonstrate the effectiveness of a
curcumin
pre-treatment strategy for ... To arrive at these results,
researchers formulated a curcumin
...
|
-
TopNews United States -
Olivia
Conroy -
Apr 29,
2010
It has found
curcumin, found in turmeric
can help ovarian cancer cells become
... Researchers have
stressed that even very small amount of
curcumin can have
...
|
-
Oneindia
-
Apr
29, 2010
Washington, Apr 29 (ANI): Pre-treatment with a
component of the spice turmeric, called
curcumin, makes
ovarian cancer cells more vulnerable to chemotherapy
...
|
-
The Press Association
-
Apr 28, 2010
Researchers pre-treated ovarian tumours with
curcumin,
a component of the yellow ... The
curcumin
sensitised the cancer tissue, making it more vulnerable to
...
|
-
Scotsman -
John
von Radowitz -
Apr
28, 2010
American researchers pre-treated ovarian tumours
with curcumin, a component of the spice turmeric,
delivered in the form of microscopic
...
|
-
PhysOrg.com
-
Apr
28, 2010
His studies have found that
curcumin also
can lower the number of IGF-1R and
... However, Majumdar's
laboratory has tried out the
curcumin treatment with
...
|
-
Lew Rockwell -
Bill
Sardi -
Apr 27,
2010
Yet, in recent years, a growing body of data points
to certain health benefits from employing mega-dose antioxidants,
such as vitamin C, curcumin and
...
|
|
-
Irish Times -
Dónal
O'Mathúna -
Apr
26, 2010
The principal active ingredient is called
curcumin,
which has been used to treat ... In recent years, attention
has been directed towards using
curcumin to
...
|
|
-
allvoices
-
Apr
26, 2010
One popular supplement used for the treatment of
herpes is turmeric extract, commonly known as
curcumin.
Turmeric is anti-inflammatory and makes the body
...
|
-
Hindustan Times
-
Apr
25, 2010
Curcumin, the active ingredient that gives
turmeric its characteristic yellow
... In 2007, US
researchers reported that curcumin helped stimulate the
immune ...
|
-
Huffington Post (blog)
-
Apr 24, 2010
For example, the isoflavones of soy, the
resveratrol of grapes, the curcumin of turmeric, the
isothiocyanates and indoles of broccoli and the catechins of
...
|
-
Stop Aging Now -
Gale
Maleskey -
Apr
23, 2010
If you have diabetes, you might want to consider
taking a curcumin supplement. New research indicates that
curcumin,
...
|
-
Take Part (blog)
-
Apr
21, 2010
Curcumin is the active ingredient in
turmeric and gives curry its distinct
... Aside from the
cheery color it provides, curcumin offers another reason
to be ...
|
-
About - News & Issues (blog)
-
Apr 20, 2010
After following a
curcumin-enhanced diet
for four or eight weeks, ... It's likely that these
benefits stem from curcumin's ability to curb
inflammation, ...
|
-
Mail Tribune -
Michael
Altman -
Apr 19,
2010
In an interview, he recently revealed that more
than 1000 cancer patients there are currently taking
curcumin
from turmeric. They're receiving neither
...
|
-
Denver Post
-
Apr
19, 2010
A new study on mice found that
curcumin
— the active ingredient in turmeric — broke up brain plaques
of amyloid beta, the abnormal protein buildup that is a
...
|
-
Toronto Sun -
Richard
Beliveau -
Apr
18, 2010
There are isoflavones in soy, resveratrol in
grapes, curcumin in the spice turmeric, isothiocyanates
and indoles in broccoli and catechins in green tea.
...
|
-
Natural News.com -
David
Jockers -
Apr
17, 2010
The major ingredient
curcumin is what
gives turmeric its characteristic orange color. The curcuminoids
within turmeric are said to be 5-8 times stronger at
...
|
-
Collie Mail -
Elysia
Tilbrook -
Apr
14, 2010
The last round of treatment was with
curcumin
which is derived from turmeric. “The tumour reacted to it so it
is definitely working,” she said.
...
|
-
New York Times (blog)
-
Apr 14, 2010
Do you believe
curcumin can have a
positive effect on myeloma? I am no expert on
curcumin,
and there is little published work on it, mostly in the test tube
...
|
|
-
The Myeloma Beacon -
Kate
Keets -
Apr 12,
2010
Julie Shilane: There is an ongoing discussion about
curcumin in our forums. Julie Shilane: Dear Dennis,
Thanks for sharing information about your brother's
...
|
-
Daily Break News - April 10, 2010
Curcumin may spice up your regimen for
disease prevention, longevity and healthy skin. When your skin is
tight, it's crying out for moisture.
...
|
-
abc7.com - April 9, 2010
Curcumin in curry powder is a strong
anti-inflammatory found mainly in Indian food that may support
reducing heart disease to dementia.
...
|
-
Orlando Sentinel (blog) - April 8, 2010
A new study on mice found that
curcumin
– the active ingrediant tumeric – broke up brain plaques of
amyloid beta, the abnormal protein build that is a
...
|
-
News-Medical.net - April 8, 2010
Lastly, the research team used the newly discovered
molecular pathway to show that blocking the acetylation of p53
with a compound called curcumin can also
...
|
-
OregonLive.com -
Bill
Graves - April 8, 2010
... Science Expo with a project titled,
"Acetaldehyde-Ovalbumin Adduct Inhibition Through the
Utilization of the Nucleophilic Properties of
Curcumin.
...
|
-
The Emory Wheel -
Mithu
Maheswaranathan - April 6, 2010
... cancer metastasis, and is currently
investigating the potential effects of
curcumin analogs
as potential anti-metastatic drugs for her honors thesis.
|
-
The Myeloma Beacon -
Funmi
Adewale - Apr 1, 2010
Julie Shilane: There is an ongoing discussion about
curcumin in our forums.
... Lawrence Dumas: We use
curcumin in much of our cooking.
...
|
-
The News Journal -
Vicki
Huber Rudawsky - Mar 31, 2010
Turmeric contains
curcumin, which is an
inflammation-fighting antioxidant, and wheat germ contains vitamin
E, an anti-oxidant that decreases exercise
...
|
-
Pravda - Mar 30, 2010
... provokes health loss and restrains
growth of cancerous cells. This effect is made possible by
curcuma, to be more exact, its fragrant component
curcumin.
|
-
TheDailyDust (satire) (blog) - Mar 29, 2010
American scientists reckon that
curcumin
might have a place in preventing the onset of dementia, while the
Irish based Cork Cancer Research Centre points to
...
|
-
Toronto Sun -
Richard
Beliveau - Mar 28, 2010
RICHARD BELIVEAU, QMI Agency
Curcumin, the
primary compound found in the Indian spice turmeric, is becoming
increasingly well known as a nutrient with
...
|
-
Examiner.com - Mar 28, 2010
Now there's also new research showing that the
natural spice turmeric, which is used to flavor Indian curries,
contains a phytochemical known as
curcumin
...
|
-
Times LIVE - Mar 28, 2010
Reuters, Sapa-dpa A STUDY published in Gut, a
British Medical Journal title, contains findings by Austrian
scientists that feeding the compound
curcumin to
...
|
-
International Business Times Australia - Mar
28, 2010
Scientists have revealed that
curcumin, a
major component in turmeric helps to treat liver
...
Curcumin
is also useful in treating jaundice and blemishes.
...
|
-
infocera -
Rajni
Sharma - Mar 28, 2010
Curcumin was added to the diets of rodents
with chronic liver inflammation and their
... Tests results
has proven that Mice that were fed, with
Curcumin,
...
|
-
Atlanta Business Chronicle -
Urvaksh
Karkaria - Mar 27, 2010
Researchers at Emory Winship Cancer Institute have
shown that the enzyme RSK2 (ribosomal S6 kinase 2) promotes tumor
invasion and metastasis in head and
...
|
-
WCTV - Mar 26, 2010
Researchers with Austria's Medical University Graz
fed the compound, called curcumin, to mice. They found it
helped reduce the inflammation that can lead to
...
|
-
Stop Aging Now -
Gale
Maleskey - Mar 26, 2010
Both cinnamon and
curcumin (found in
turmeric) stimulate insulin receptors on cells the same way
insulin does, lowering blood sugar by as much as 30%.
...
|
-
TopNews United States -
Prakash
Sharma - Mar 26, 2010
According to a latest study,
curcumin, a
chemical in turmeric, which gives curry a yellow color, might end
up slowing the progress of liver diseases.
...
|
-
World News - Mar 25, 2010
These cells play a central role in developing
inflammation in the bile duct. Researchers also state that
curcumin
in the future may have manifold targets in
...
|
-
BusinessWeek - Mar 25, 2010
Consuming
curcumin significantly reduced
bile duct blockage and curbed ...
Curcumin
interferes with several chemical signaling pathways involved in
the ...
|
-
Independent - Mar 25, 2010
The yellowness of turmeric, known as the polyphenol
curcumin, has been found to have anti-inflammatory and
antioxidant properties and on March 24
...
|
-
World News - Mar 24, 2010
Researchers state that
curcumin; a
component found in turmeric can help to
...
Curcumin
has been used in Indian Ayurvedic medicine to cure a range of
...
|
-
Natural Products Industry Insider - Mar 24,
2010
CHENNAI, India—Curcumin's antioxidant
powers appear to help reduce oxidative stress in the eye, which
could prevent cataract development, according to
...
|
-
Scottish Daily Record -
Lachlan
Mackinnon - Mar 24, 2010
Curcumin, a component of the spice
turmeric, appears to prevent inflammation
... Tests in
Austria showed curcumin significantly reduced bile duct
blockage ...
|
-
EmpowHer (blog) - Mar 22, 2010
Researchers believe that the
curcumin it
contains works by shutting down the
... If it is not
curcumin,
we need something a lot like
curcumin — something
...
|
-
eMaxHealth -
Denise
Reynolds - Mar 17, 2010
Always wear sunscreen of at least 15 SPF • One
study from the University of Rochester Medical Center found that
curcumin,
a spice found in curry dishes, ...
|
Sunday Times.lk - Mar
15, 2010
The pigment of turmeric (curcumin) valued for its
yellow-orange colour can be used to garnish pale foods, apart from being
a potent dietary antioxidant. ...
The Freeport News - Mar
15, 2010
Turmeric - a powerful East-Indian herb used in curry
dishes, turmeric extract contains curcumin which is a strong
anti-inflammatory. Curcumin helps lower
...
Turmeric: Turmeric contains the potent ingredient
curcumin
which is thought to protect against inflammation and may help relieve
the pain and stiffness of ...
Curcumin, magnesium, blackseed oil (Nigella
sativa) and herbal oleander extract are all powerful immune modulators
which may help. ...
Nilesh found that
curcumin, a natural supplement
that is a member of the ginger family, worked well and could possibly
serve as a treatment for the disease.
...
FemaleFirst.co.uk - Mar
11, 2010
Curry causes problematic stains due to the bright yellow
molecule called curcumin which is found in turmeric. Turmeric can
be used as a dye for clothes as ...
Also, there are many natural substances such as
curcumin
and resveratrol that are showing very promising results in treating colon
and many other types of ...
Vitals Spotlight - Mar
4, 2010
An extract in turmeric called
curcumin, which gives
curry its yellow color, is an amazing anti-inflammatory. I also like
Vitamin D as a prevention ...
BETTER Health Research - Feb
25, 2010
An alternative to Celebrex ® would be to take a
nutritional supplement for arthritis and joint pain such as ginko and
curcumin.
StarNewsOnline.com - Feb
24, 2010
Curcumin can reduce the risk of Alzheimer's disease
and cancer. It works even better when taken with vitamin D3. It is known
also to lower blood sugar and ...
Curcumin and turmeric have been touted as
anti-inflammatory. Cinnamon may help increase metabolic function.
Experiment with new flavors and see if you can
...
Natural Products Marketplace -
Feb 22, 2010
“We're delighted to sponsor the Medicine Hunter's seminar
about the powerful benefits of curcumin as an immune enhancer,
inflammatory response balancer, ...
Lawrence Journal World -
Tom
King - Feb 22, 2010
And
curcumin, a constituent of turmeric, kills
cancer cells. A 2009 BBC News story about the findings of the CCRC stated
that “curcumin started to kill
...
The Province - Feb
21, 2010
The spice, and its active ingredient
curcumin, also
provide medicinal benefits: it acts as an antiseptic and antibacterial
agent. ...
The results of a study published in The Journal of
Nutrition reveals that Curcumin, a bioactive component in Indian
spice turmeric, can prove effective in ...
Its rich
curcumin content is applauded for
decreasing irritability in the bowels, lowering LDL cholesterol and
fighting cancer by counteracting oxidative
...
Middle East North Africa Financial
Network - Feb 18, 2010
The research projects include the 'characterisation of
curcumin
signal transduction and apostosis as possible target for chemotherapy' and
the 'novel ...
Curcumin has been garnering increased attention as a
potential anticancer treatment. It is the major active compound in
turmeric, a popular Indian spice ...
Oneindia - Feb
16, 2010
17 (ANI):
Curcumin, a bioactive component in Indian
spice turmeric, can prove effective if added in weight loss routine, a new
study suggests. ...
Curcumin, a bioactive constituent in turmeric, can
prove effectual if added in weight loss schedule, a new research has
suggested. ...
Curcumin is an “active component” in the spice's
effect on cancer cells, but it is scarce in nature, he said. “Our goal
is to determine whether there are ...
(NaturalNews) Mainstream health experts have estimated that
up to 40% of all cancer could be prevented with more immunizations against
diseases that ...
Curcumin protects against a wide range of cancers
including lung and colorectal cancers. Studies have found that
curcumin
is especially beneficial for those ...
Recently, turmeric powder was in the news for evidence that
it contains curcumin which can fight Alzheimer's and Dementia, as
well as for having anti-cancer ...
Natural Products Marketplace -
Feb 12, 2010
Spicy Brain Food:
Curcumin works to reduce the risk
of Alzheimer's disease, and taking it with vitamin D3 may enhance the
effects. ...
Curcumin is another highly proven cancer fighter and
preventative. Black Cumin Oil (Nigella Sativa) has been highly revered
throughout history. ...
Herald & Review - Feb
9, 2010
Curcumin can reduce the risk of Alzheimer's disease
and cancer. It works even better when taken with vitamin D3. Speaking of
curcumin,
it is known to lower ...
Albany Times Union (blog) -
Carin
Lane - Feb 9, 2010
Turmeric, also known as
Curcumin, is a raw vegetable
that's similar to ginger. It's full of antioxidants that keep your brain
cells from dying. ...
A study at the Cork Cancer Research Centre showed that
curcumin,
which is a chemical found in the spice turmeric, rapidly killed laboratory
cancer cells. ...
Toronto Star - Jan
29, 2010
The reason: It's thought to be the
curcumin-
derivative turmeric found in curry (and inexpensive mustards). Savour a
little chocolate. ...
Known by its Latin name,
curcumin, turmeric shows
promise as an antifungal for Candida as well as many other fungal
infections. According to the Journal of
...
And research points to
curcumin as being one of the
roots of that. Curcumin is the phytochemical that gives turmeric
powder its distinctive bright ...
Irish Independent - Jan
25, 2010
Turmeric's
curcumin compound has long been
celebrated in Asian cuisine and Ayurveda medicine for its
anti-inflammatory, antiseptic and antioxidant power.
...
Meanwhile, University of Missouri, United States,
researchers have found that curcumin, a popular Indian spice
derived from the turmeric root, could reduce
...
Public Service - Jan
20, 2010
The chemical
curcumin found in the curry spice
turmeric destroys gullet cancer cells in the lab, scientists at the Cork
Cancer Research Centre have found. ...
Curcumin from turmeric has been extensively studied
for its anti cancer properties, specifically by Bharat B. Aggarwal, PhD.,
professor of experimental ...
Pak Watan - Jan
19, 2010
The chemical -
curcumin - has long been thought to
have healing powers and is already being tested as a treatment for
arthritis and even dementia. ...
Kansas City infoZine - Jan
17, 2010
The powerful spice's active ingredient is
curcumin,
an antioxidant with anti-inflammatory properties. Some studies indicate
that curcumin may slow the
...
Gather.com - Jan
15, 2010
Scientists and all those famous "old wives" have
long thought that the chemical, which is called
curcumin, has
healing powers for everything from arthritis
...
Times Online - Jan
15, 2010
As used liberally in Gordon Ramsay's recipes, this is a
great source of curcumin, which is believed to have
anti-inflammatory effects and may help to fight
...
Online - International News Network -
Jan 7, 2010
For centuries, doctors practicing traditional Indian
medicine have safely prescribed curcumin in extract form for a
variety of illnesses and ailments. ...
The study, posted online in the journal Breast Cancer
Research and Treatment, indicated that the finding of
curcumin
(from turmeric) and piperine (from ...
Currently, there are 37 clinical trials in progress in the
United States evaluating its active ingredient,
curcumin, for
inflammatory conditions and other ...
Another possibility is development of several plant-derived
small molecules, such as honokiol and curcumin, that have been
shown to inhibit COX without ...
Modern research has uncovered more benefits to the spice,
particularly its active ingredient, curcumin. Just like most
spices, it is naturally antimicrobial ...
Curcumin is another spice that is used in Indian
cooking. We just published a paper with Dr. Reddy's lab, showing that that
curcumin, which is known to ...
EmpowHer - Dec
30, 2009
Curcumin, from the spice turmeric which is commonly
used in Indian food; 8. Resveratrol, found in grapes and sold as a dietary
supplement; 9. ...
In addition to being a holy smokes anti-inflammatory,
curcumin
is also rich in anti-oxidants and helps detoxify the liver. And it gives
curries that ...
Natural News.com -
Sl
Baker - Dec 29, 2009
Researchers at the University of Michigan (UM)
Comprehensive Cancer Center have found that the compounds
curcumin,
which is derived from turmeric, ...
Curcumin's medicinal properties are now also thought
to be able to protect liver and kidney function, ward off Alzheimer's
disease and even kill cancer ...
Indianapolis Star - Dec
23, 2009
They reached this conclusion when the dietary compounds
curcumin,
derived from the Indian spice turmeric, and piperine, derived from black
peppercorns, ...
About - News & Issues (blog) -
Dec 22, 2009
A combination of
curcumin (a compound found in the
curry spice turmeric) and piperine (a substances derived from black
peppers) could help protect against ...
Dr. Cummings is one of the authors in a study published in
2005 which says that there is a potential role for the curry spice
curcumin
(turmeric) in the ...
Turmeric contains
curcumin, which is the potent
substance that targets and attacks cancer cells, while leaving normal
cells well enough alone. ...
An alternative to Celebrex would be to take a nutritional
supplement for arthritis and joint pain such as ginko and
curcumin.
Huffington Post (blog) - Dec
18, 2009
Alcohol is detoxified by the liver; therefore, another
highly recommended strategy to protect the liver is to use
curcumin,
the substance that gives the ...
Behavioral Health Central (blog) -
Dec 17, 2009
A new study, 'Curcumin attenuates the effects of
insulin on stimulating hepatic stellate cell activation by interrupting
insulin signaling and attenuating ...
Raise HDL with niacin (nicotinic acid), dark chocolate
(minimum 70% cocoa mass), curcumin (extract of turmeric), kale
(juiced) or hibiscus tea. ...
Reading Little India - Dec
16, 2009
A study in the British Journal of Cancer reports that
curcumin,
the compound in turmeric, kills cancer cells within 24 hours. Principal
researcher Dr Sharon ...
Researchers at the University of Michigan Comprehensive
Cancer Center applied piperine, found in black pepper, and
curcumin,
the main ingredient in the ...
Effects of
curcumin treatment on the cell lines
included: mitotic catastrophe, autophagy, accumulation of
poly-ubiquitinated proteins and cyclin B
...
Irish Times - Dec
14, 2009
A study carried out at University College Cork recently
captured headlines when the researchers showed that
curcumin, a
component of the spice turmeric, ...
Express Buzz - Dec
13, 2009
The project, which includes clinical trials using a drug
made from 'curcumin', a component found in turmeric, will test the
medicine on 210 patients who are ...
U.S. News & World Report -
Dec 11, 2009
When
curcumin (from turmeric) and piperine (from
black peppers) were applied to breast cells in the laboratory, the number
of stem cells decreased, ...
Wisconsin State Journal - Dec
5, 2009
New studies suggest that
curcumin, the bright yellow
compound in turmeric, may help inhibit cancer cells, reduce inflammation
and safeguard the brain, ...
Dr. Cutler - Dec
2, 2009
The ingredient,
curcumin, is a potent antioxidant
found in the turmeric spice that is currently being tested for its safety
and effectiveness for fighting ...
Interestingly, the curry spice
curcumin has also
been shown to 'reduce memory deficits in animal models of Alzheimer's
disease and brain trauma'. ...
spectroscopyNOW.com - Nov
30, 2009
They are also planning to screen a range of antioxidant
compounds, such as green tea extract, curcumin (from the spice
turmeric), and resveratrol (from red ...
The protein, kappa B (NF-KB), was blocked by apple extract
and curcumin. Resveratrol was also studied, but did not produce the
same results. ...
Daily News & Analysis - Nov
27, 2009
PTI Hyderabad: A new research at the Indian Institute of
Sciences (IIsc) in Bangalore has found that a drug combined with
curcumin
from turmeric can prove ...
The Healthier Life - Nov
25, 2009
Take 300mg of
curcumin (an active component of the
yellow spice turmeric) three times a day to increase the solubility of
your bile. ...
Jakarta Post - Nov
24, 2009
He found the trend was for
curcumin – an
ingredient found in turmeric, a ginger-family plant native to India and
Southeast Asian countries. ...
Curcumin minimizes or eliminates plaque and
inflammation. Vitamin B12 with folic acid and B6 are good for brain health
too. Hosphatidyl serine supplements ...
Times of India - Nov
22, 2009
Dr Krishna Misra from Indo-Russian Centre for
Biotechnology, IIIT spoke on "The application of
curcumin and
some of its conjugates as anti-tumour agents.
...
Curcumin's medicinal properties are now also thought
to be able to protect liver and kidney function, ward off Alzheimer's
disease and even kill cancer ...
Science Daily - Nov
20, 2009
They also plan to screen antioxidant compounds such as
green tea extract, curcumin and resveratrol (found in red wine) to
see if such compounds are capable ...
DSO Maghreb - Nov
18, 2009
Curcumin may spice up your regimen for disease
prevention, longevity and healthy skin. When your skin is tight, it's
crying out for moisture. ...
Los Angeles Times - Nov
18, 2009
In broad brush strokes, fish oil,
curcumin,
antioxidant-rich fruits and vegetables -- they're anti-inflammatory.
Saturated fats, trans fats, ...
Natural News.com (registration) -
Nov 17, 2009
Vitamin D,
curcumin, chaparral, garlic, and aloe
vera are a few of the many beneficial nutrients that will serve the body
well in preventing cancer. ...
Jackson Clarion Ledger - Nov
16, 2009
Turmeric, the yellow spice in curry powder, contains
curcumin.
This compound is being studied as a possible treatment for autoimmune
diseases, ...
Researchers are also testing whether samples of the curry
spice curcumin, when encapsulated in liposomes, are more
effectively transferred into the ...
A study in the Journal of Agricultural and Food Chemistry
is looking into nano-sized capsule made with
curcumin, an
ingredient that makes curry yellow, ...
... "high-tech and ancient," for its use
of natural ingredients, especially Ayurvedic herbs like noni and
curcumin,
to reach specific biological needs. ...
Curcumin: This component of the spice, turmeric, has
been known to improve insulin resistance and regulate spikes in blood
glucose levels. ...
... treatment in the curry spice, turmeric.
Oesophageal cancer cells that were treated with
curcumin, the
active compound in turmeric, died within 24 hours.
Flesh and Stone - Nov
2, 2009
Curcumin spice, a derivative of turmeric, is an
antioxidant known in Thailand for having anti-inflammatory and anti-cancer
properties. ...
They found that
curcumin started to kill cancer
cells in 24 hours – and that the cells began to digest themselves,
according to research published in the
...
EndoNurse -
Oct 30, 2009
CORK, Ireland—Researchers from the University College Cork
and Mercy University Hospital, Cork, reported
curcumin started
killing cancer cells within 24 ...
Lab tests at the Cork Cancer Research Center showed that
the chemical curcumin, found in turmeric, started destroying the
throat cancer cells within a day ...
The National Online -
Oct 29, 2009
The chemical –
curcumin – has long been thought to
have healing powers and is already being tested as a treatment for
arthritis and even dementia. ...
Food Consumer -
Oct 29, 2009
For the study, researchers at the Cork Cancer Research
Center in Ireland treated cultured esophageal cancer cells with
curcumin
- the yellow pigment found ...
Examiner.com -
Oct 29, 2009
In the current addition of the British Journal of Cancer, a
team of scientists from the Cork Cancer Research Centre reported that
the chemical curcumin,
...
The Daily Inquirer -
Oct 29, 2009
Scientists at the Cork Cancer Research Center in Ireland
have treated esophageal cancer cells with
curcumin. Circumin is a
chemical found in the spice ...
Mother Nature Network -
Oct 29, 2009
Curcumin — an extract from the bright yellow curry
spice turmeric — has long been ascribed healing powers, and is already
undergoing tests for treating ...
The red top reports on research that the chemical
curcumin, which is found in turmeric – a common curry spice – kills
cancerous cells after less than 24 ...
Previous scientific studies have suggested
curcumin
- which gives curries a distinctive yellow colour - can suppress tumours
and that people who eat lots of ...
The Mercury (subscription) -
Oct 28, 2009
Researchers at the Cork Cancer Research Centre in Ireland
treated oesophageal cancer cells with
curcumin - a chemical found
in turmeric, which gives curries ...
Examiner.com -
Oct 28, 2009
Could be so: A chemical called
curcumin, which is
found in the bright-yellow curry spice tumeric, has been shown to kill
cancer cells. ...
New research on Turmeric and a chemical component of it
called Curcumin showed that
Curcumin destroyed esophageal
cancer cells within 24 hours. ...
When scientists treated esophageal cancer cells with
curcumin, found in the spice turmeric, it started to kill the cells
within 24 hours, the team reported ...
Ozarks First -
Oct 28, 2009
They found that esophageal cancer cells treated with the
chemical curcumin started to die off within 24 hours. The
chemical also made the cancer cells start
...
Not surprisingly, turmeric and its most active component,
curcumin, have been receiving wide-ranging scientific study,
probably more so than any other spice
...
The chemical -
curcumin - has long been thought to
have healing powers and is already being tested as a treatment for
arthritis and even dementia. ...
In an exciting new find, researchers reported on Wednesday
that curcumin has been found effective in killing esophageal
cancer cells. ...
NHS Choices -
Oct 28, 2009
This was a laboratory study investigating how oesophageal
cancer cells respond when coming into contact with
curcumin, a
chemical found in the Indian spice ...
RedOrbit -
Oct 28, 2009
Curcumin, a chemical found in the spice turmeric,
gives curries a distinctive yellow color, but researchers at the Cork
Cancer Research Center in Ireland ...
Sideways News -
Oct 28, 2009
Scientists at University College Cork (UCC) in Ireland
found that curcumin, a compound found in turmeric, began killing
oesophageal cancer cells within 24 ...
Examiner.com -
Oct 28, 2009
A study published today (October 28, 2009) in the British
Journal of Cancer reveals that curcumin, a compound in turmeric,
kills esophageal cancer cells in ...
PRESS TV -
Oct 28, 2009
While many studies are assessing the effects of
curcumin
- a compound commonly found in curry - in treating arthritis and dementia;
the study published in ...
Scientists have identified these additional health benefits
of the chemical curcumin, which is already being tried as
arthritis and dementia treatment, ...
TheMedGuru -
Oct 28, 2009
A team of scientists based at the Cork Cancer Research
Centre conducted a lab experiment to determine the therapeutic value of
chemical curcumin found in
...
680 News -
Oct 28, 2009
Research done at the Cork Cancer Research Centre in Ireland
shows curcumin, which is what gives curry the yellow color can
kill some cancer cells in a lab ...
India Business Blog (blog) -
Oct 28, 2009
by ANI on October 28, 2009
Curcumin may protect
smokers from nicotine-induced head, neck cancers Washington, October 5
(ANI): Curcumin, a compound that is
...
Curcumin, a component of the yellow spice turmeric,
found in curry, may have special anti-inflammatory properties in the
eyes, where a layer of yellow ...
This could lead to a dangerous or even lethal bleeding
episode, so no one on warfarin should take turmeric or its active
ingredient curcumin.
...
Curcumin, the bright yellow pigment in tumeric,
helps fight heart disease and may boost brain health, possibly
protecting against Alzheimer's disease.
...
EmpowHer (blog) -
Oct 19, 2009
Curcumin from turmeric inhibited the growth of
bladder cancer cells in mice and in cell cultures in studies at Texas
A&M University. ...
Horsetalk -
Oct 18, 2009
The British researchers explored
curcumin
(diferuloylmethane), which comes from the spice turmeric. Tumeric is
produced from the plant Curcuma longa.
...
One of these recently targeted plants include Curcuma longa
(luyang dilaw) whose medicinal extract called
curcumin has been
found to prevent the formulation ...
Examiner.com -
Oct 16, 2009
This extremely detailed and scientific presentation also
gave credence to the centuries old use of the common Indian spice,
Turmeric, rich in curcumin which
...
Curcumin: This component of turmeric has emerged as
a leading cancer fighter. Curcumin can disrupt cancer cells in
several stages of development. ...
tayyar.org -
Oct 13, 2009
The yellow curry pigment
curcumin may fight
Alzheimer's by thwarting development of the disease's signature amyloid
brain plaques, says a study. ...
Curcumin, an extract of the spice turmeric, is a
natural product with potent anti-inflammatory properties that also
exerts beneficial effects on cartilage
...
About - News & Issues (blog) -
Oct 12, 2009
In previous studies, researchers have shown that natural
compounds such as curcumin (an anti-inflammatory agent found in
the curry spice turmeric), ...
One thing you can do is to take a
curcumin
supplement. Canadian researchers found that rats treated for one month
with curcumin did not experience the
...
Curios researchers that flocked to test the powder in the
last few decades, identified curcumin as the chief active
ingredient in turmeric. ...
"Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes
and Angiogenesis and Obesity in C57/BL Mice. 919-925." Turmeric and an
ingredient in it, curcumin has
...
About - News & Issues (blog) -
Oct 6, 2009
Past studies show that a combination of
curcumin (a
compound found in the curry spice turmeric) and vitamin D may also help
clear the brain of amyloid beta. ...
Herald Publications -
Oct 5, 2009
Curcumin, the active ingredient in turmeric or 'haldi',
may inhibit the adverse effects of nicotine in patients who have head or
neck cancer, but continue ...
Curcumin/Turmeric root - One of the best
anti-inflammatories, it has been used for centuries. A Cornell
University study found that it did decrease joint
...
U.S. News & World Report -
Oct 5, 2009
MONDAY, Oct. 5 (HealthDay News) -- In a finding that could
have a major impact on the diagnosis and treatment of one of the most
deadly types of cancer, ...
TheMedGuru -
Oct 5, 2009
by Kangna Agarwal - October 5, 2009 New York, October 5 --
Curcumin, a yellow pigment found in turmeric, the Indian spice, may
block nicotine from ...
The cells were pre-treated with
curcumin, the
compound that gives curry its yellow/orange color. Then the scientists
introduced nicotine to the cell lines.
...
Times of India -
Oct 5, 2009
Curcumin, a compound that is found in the India
curry spice turmeric, seems to be effective in stopping nicotine's
adverse effects in smokers with head and
...
Medical News Today -
Oct 5, 2009
Researchers found that
curcumin, a compound found in
turmeric, the Indian spice that gives curry its orange-yellow colour,
may block nicotine from ...
The cells were pre-treated with
curcumin, the
compound that gives curry its yellow/orange color. Then the scientists
introduced nicotine to the cell lines.
...
Patients with head and neck cancer who continue to smoke
could benefit from curcumin, the ingredient found in the spice
turmeric. ...
The Press Association -
Oct 4, 2009
People suffering from a deadly family of cancers have been
given new hope after American scientists identified 231 previously
unknown genes associated with ...
Science Daily (press release) -
Oct 4, 2009
ScienceDaily (Oct. 4, 2009) —
Curcumin, the compound
that gives curry powder its yellow/orange color, may inhibit the adverse
effects of nicotine in ...
Sunday Oct 4, 2009 (foodconsumer.org) --
Curcumin,
the yellow pigment found in curry powder and turmeric may
...
PResearchers at the University of Southampton believe that
...
A study from the September issue of Psychopharmacology used
piperine as well as the Ayurvedic cure
curcumin (the Indian spice
found in tumeric commonly used ...
University of Missouri researchers have found that
curcumin, a popular Indian spice derived from the turmeric root,
could reduce the cancer risk for women
...
New America Media -
Oct 2, 2009
... I did a little digging in the medical literature
on turmeric's benefits and discovered that it contained
curcumin,
a potent anti-inflammatory compound. ...
Curcumin, an extract from turmeric, curbs
inflammation, and vinpocetine, a periwinkle extract, improves cerebral
blood flow. Phosphatidylcholine (PC) and
...
NewsReleaseWire.com (press release) -
Oct 1, 2009
Aerobic exercise and various nutrients can improve BDNF
levels (pantethine, acetyl-l-carnitine, blueberries, fish oil,
curcumin, and likely many others).
...
The theory is that the combination of vitamin D3 and
curcumin
stimulate the immune system in a fashion that helps clear amyloid beta,
the "gunk" that forms ...
Prison Planet.com - Sep
29, 2009
Flavonoids are third on the list, namely
curcumin,
quercetin, ferulic acid and ellagic acid, particularly in a mixture. The
curcumin
and quercetin in ...
Preclinical data have shown that
curcumin, the major
active constituent of the dietary spice turmeric, can both inhibit the
formation of tumors in animal ...
Natural News.com (registration) -
Paul
Fassa - Sep 26, 2009
An hour or so before the shot or nasal mist spray, take a
high dose of curcumin and quercetin! Blaylock says these two
flavonoids mixed, even with other ...
Examiner.com - Sep
25, 2009
So can you help lower the risk of Alzheimer's by getting
more sleep and taking specific spice extracts such as
curcumin
(from turmeric) that reversed ...
Hamilton Spectator - Sep
25, 2009
A Chinese doctor will spend the next two years at St.
Joseph's Healthcare doing research to show the effectiveness of using
curcumin,
which is an extract of ...
Its active ingredient,
curcumin, is prized in its
native south Asia for its anti-inflammatory and antiseptic properties.
American researchers are even ...
The herb
curcumin may benefit people with
pancreatitis or pancreatic cancer. Suzy Cohen is a registered pharmacist.
The information presented here is not ...
The Guardian - Nigeria - Sep
23, 2009
In vitro studies with capsaicin, dihydrocapsaicin (and
curcumin)
also exhibited a concentration effect for the resistance to copper-induced
serum lipid ...
Clinical
trials of curcumin
ADVANCE for Speech-Language Pathologists
and Audiologists - Sep 24, 2009
They then blocked this effect by feeding the flies large
doses of the spice curcumin [Sleep, 32 (8): 984-992] "Clinical
trials of curcumin to reduce risk of
...
Journal of Neuropsychiatry -
Sep 23, 2009
Novel treatments with anti-inflammatory drugs, insulin,
thiazolidinediones, omega 3 fatty acids,
curcumin, statins, and
others have brought new hope for ...
Meanwhile, neurologists at the University of California are
investigating whether a combination of omega-3 fatty acids and
curcumin,
an antioxidant found in ...
Turmeric has
curcumin and will help to stimulate
bile flow in the liver and can help protect the liver from the dangers of
toxins. ...
The herb
curcumin may benefit people with
pancreatitis or pancreatic cancer. These statements have not been
evaluated by the Food and Drug Administration.
...
... Disease Research Center, is looking at the
potential for Alzheimer's prevention by controlling inflammation with
omega-3 fatty acids and curcumin.
...
Curcumin (or “curry” in culinary circles) is
considered a tonic for the body. In a recent study published at the
American Association of Pharmaceutical ...
Turmeric, typically found in curry, contains
curcumin,
a chemical with potent antioxidant and anti-inflammatory properties. In
India, it is even used as a ..
Gaea Times (blog) - Sep
15, 2009
Lately, turmeric's astonishing array of antioxidant,
anti-cancer, antibiotic, antiviral and other properties have spurred a
flurry of research into curcumin
...
Ethiopian Review - Sep
11, 2009
Scientific evaluation has shown that the rhizomes, an
underground stem system, of the plant contain curcuminoids, primarily
curcumin.
...
These supplements include vitamin D, resveratrol,
quercetin, lipoic acid, curcumin and L-arginine. The extended
version of this column is posted at my Web
...
While these ingredients are too numerous to mention them
all, some of the better-known antioxidants include green tea, pomegranate,
curcumin, resveratrol,
...
TURMERIC Loaded with a potent antiinflammatory compound
called curcumin, this yellow spice may help to increase endurance
and speed recovery. ...
Curcumin, a compound found in turmeric (a spice best
known as an ingredient in curry), is the focus of a feline cancer study
being conducted by the Colorado ...
Vitamin D,
curcumin, Mediterranean diet each may
help reduce the risk of Alzheimer's disease. UCLA in July 2009 issued a
press release to announce that its ..
Although it provides high levels of iron and manganese, its
most valued component is curcumin, which has been studied for its
anti-inflammatory properties. ...
fnbnews.com - Sep
4, 2009
Chelating property of
Curcumin and Trends in food
ingredients in Taiwan. " UMAMI Technology and Functional beverage
ingredients: the industry review. ...
Curcumin, a popular Indian spice, blocks breast
cancer cell growth in women on hormone replacement therapy, say
researchers at the University of Missouri.
...
Both studies found that
curcumin, a derivitative of
the curry spice, turmeric, to have neuroprotective effects. Researchers
from UCLA, UC Riverside and the ..
This result indicates that an enriched turmeric extract
could be just as or more effective than
curcumin, the most commonly
studied turmeric material for ...
Examiner.com - Sep
3, 2009
It has an ingredient called
curcumin that is the
important factor in reducing inflammation. Indian's have known about
turmeric for centuries and use it in ...
One of them is the
curcumin combination to control
the parasite. "Our research has provided new knowledge on parasite
biology which could pave the way for ...
About - News & Issues - Sep
2, 2009
Curcumin—a compound found in the curry spice
turmeric—may help reduce breast cancer risk for women undergoing hormone
replacement therapy during menopause, ...
Basil & Spice: Author & Book
Views On A Healthy Life! -
James
Geiger - Sep 1, 2009
Curcumin (diferuloylmethane): a yellow pigment in
the spice turmeric (also called curry powder) possess potent antiviral
activities against severe acute ...
Levels of 25(OH) at 120nmol/L will prevent cancers in
general and most adults need upwards of 2000 iu's per day. q
Curcumin
is an excellent ...
Curcumin, a compound in turmeric, appears to stop
the growth of cancer in laboratory cell tests. Turmeric is an herb related
to ginger that is often used in ...
Examiner.com - Aug
29, 2009
Curcumin is being discovered to help many problems
associated with Alzheimer's, arthritis, depression, cancer, etc. It is an
Indian spice derived from ...
They incubated these white blood cells in the presence of
amyloid and then added vitamin D3 and curcumin to the mix, both
individually and together. ...
GenomeWeb Daily News - Aug
25, 2009
New findings suggest that dietary components such as
folate, retinoids, and curcumin can have anti-cancer effects by
modulating miRNA expression, ...
[9] In studies involving mice,
curcumin has
demonstrated anti-carcinogenic activity in a variety of cancers.[10] A
compound in aged garlic significantly ...
Researchers conducted experiments on the effects of
curcumin,
a biologically active ingredient of the essential curry spice turmeric.
...
Examiner.com - Aug
20, 2009
Laboratory tests of resveratrol (derived from grapes) and
curcumin
(derived from turmeric) show promise in improving blood vessel function,
...
Curcumin: Derived from turmeric spice — studies
show it's a very powerful anti-cancer and anti-inflammatory herb.
Resveratrol: You know it as a red wine ...
About - News & Issues - Aug
18, 2009
Past research suggests that natural substances such as
cinnamon, curcumin (a compound found in the curry spice turmeric),
and ginseng may also help fight ...
Curcumin is a yellow pigment derived from turmeric,
which is commonly used as a spice and food-coloring agent. Turmeric has a
long history of use in eastern ...
Promising results were obtained, using D3 alone or together
with curcumin, an active ingredient in turmeric and curry. There is
new hope that these two ...
American Journal of Hemotology and
Oncology -
Tasheema
Prince - Aug 17, 2009
Curcumin, a popular Indian spice, blocks breast
cancer cell growth in women on hormone replacement therapy, say
researchers at the University of Missouri.
...
Los Angeles Times - Aug
14, 2009
And
curcumin (an antioxidant chemical found in
turmeric) improves ulcerative colitis, rheumatoid arthritis and
pancreatitis in mice and has anti-cancer
...
"Based on our data,
curcumin appears to
suppress angiogenic activity in the fat tissue of mice fed high fat
diets." Curcumin is an antioxidant chemical in
..
StarNewsOnline.com - Aug
13, 2009
Ask your doctor if these are right for you: Quercetin,
curcumin,
lycopene, beta sitosterol, melatonin and natural anti-fungals.
Examiner.com - Aug
13, 2009
What about turmeric or
curcumin for preventing
Alzheimer's if you're not able to fight the environmental pollution where
you have to live? ...
A combination of
curcumin (a compound found in the
curry spice turmeric) and vitamin D could help protect against Alzheimer's
disease, according to a recent ...
Examiner.com - Aug
11, 2009
Curcumin and Ginko may slightly reduce the risk of
becoming demented but do nothing to help cognition once decline has begun.
Omega 3 fatty acids seem to ...
Parkinson's Disease News - Aug
11, 2009
Exploring
curcumin (which is found in a curry spice)
as a possible treatment of Parkinson's Disease [2].
Curcumin is
already widely used, due to its ready ...
Personal Liberty Digest - Aug
10, 2009
A new study has found a combination of supplements
containing vitamin D3 and curcumin, a compound found in turmeric,
may help shield the brain from the ..
The Virtual Medical Centre -
August 6, 2009
Now, researchers at the Steele Children's Research Center
at the University of Arizona have found that
curcumin (the
biologically active ingredient in ...
Science Daily (press release) -
August 3, 2009
They then blocked this effect by feeding the flies large
doses of the spice curcumin. "Clinical trials of
curcumin
to reduce risk of Parkinson's disease are
...
Examiner.com - Jul
31, 2009
Is it true that research is beginning to show that an
ingredient, a phytochemical, in turmeric called
curcumin, actually
reverses, slows, or even helps to ...
TopCancerNews.com - Jul
29, 2009
This would seem unlikely, with similar effects reported for
other components of wine and for other natural products such as
curcumin.
...
eMaxHealth - Jul
29, 2009
Curcumin, the active ingredient in turmeric, may be
an effective treatment for inflammatory bowel disease, also known as IBD.
Researchers at the Steele ...
Turmeric has active substances—polyphenol and
curcumin,
a strong antioxidant. In Ayurveda, turmeric blocks inflammation,
anti-gastric flux and improves the ...
Examiner.com - Jul
29, 2009
As reviewed in previous articles, ingesting
curcumin,
the main component of curry, or ingesting high amounts of phenethyl
isothiocyanate , a compound found ...
Curcumin (in Turmeric) - When fed a high fat diet,
mice fed curcumin gained less weight. BONUS: These lucky mice also
showed lower cholesterol levels and ...
Times of India - Jul
23, 2009
We used solid state NMR spectroscopy on
curcumin to
discover how its molecules act like a biochemical disciplinarian. In our
very recent research, ...
The Guardian - Nigeria - Jul
22, 2009
Also, University of Missouri, United States, researchers
have found that curcumin, a popular Indian spice derived from the
turmeric root, could reduce the ...
An increasing body of research shows
curcumin, the
main active ingredient in turmeric root, is a powerful antioxidant and
anti-inflammatory that could fight ...
Hindu Business Line -
Gk
Nair - Jul 22, 2009
Consequently, the demand for the 'Alleppey Finger Turmeric
(AFT)', which is famous for its high curcumin content, has dropped
considerably in recent years ...
Modern Medicine - Jul
21, 2009
After 16 weeks, they found that mice fed
curcumin
had a 26 percent reduction in lipid deposits, and an examination of gene
expression showed that the ...
University of Missouri researchers have found that
curcumin,
a popular Indian spice derived from the turmeric root, could reduce the
risk of breast cancer ...
Bartlesville Live - Jul
21, 2009
Researchers say
curcumin, which gives curry that
distinctive yellow color, lowered levels of fat deposits in Mice. A news
release on the study states, ...
Business Exchange - Jul
21, 2009
... disease-modifying drug candidate for treatment
of Parkinson's disease Gerard Griffioen, PhD, NV reMYND, Leuven, Belgium
Exploring curcumin and.
...
The West Australian - Jul
21, 2009
Researchers found
curcumin, a component of the spice
turmeric, inhibited progestin-induced VEGF secretion from breast cancer
cells. Curcumin decreased the
...
Examiner.com - Jul
21, 2009
Curcumin and vitamin D—both individually and
together—appear to have properties that help protect against Alzheimer's
disease. Does this mean you should ...
U.S. News & World Report -
Ed
Edelson - Jul 21, 2009
Two French research teams are reporting studies describing
the range of genes that are affected by
curcumin, the active
ingredient in turmeric, ...
Reader's Digest - Jul
21, 2009
Small studies have found that
curcumin, a component
of turmeric, cuts cholesterol. Heat a little oil in a sauté pan, and toss
in a tablespoon of turmeric, ...
As long as you're spicing up your diet and weight-loss
routine with capsaicin, you might as well add a little
curcumin,
the bioactive component in turmeric ...
Curcumin, the main ingredient in the curry spice
turmeric, is a naturally occurring antioxidant known as a polyphenol.
Polyphenols are found in plants that ...
July 20, 2009 -- An apple a day is said to keep the doctor
away, but orange juice may be good at the job, too.
...
Turmeric, known as
curcumin, reduces inflammation in
the body, and recent medical studies indicate that men who eat turmeric
consistently have lower levels ...
Personal Liberty Digest - Jul
20, 2009
New research shows that
curcumin found in the Indian
spice turmeric may help reduce some women's risk of breast cancer if they
utilized hormone replacement ...
Researchers say properties of vitamin d and
curcumin...which
is found in the curry spice, turmeric, may help stimulate the immune
system to clear the brain ...
Its major active constituent is the polyphenol
curcumin
(diferuloylmethane). It exhibits several molecular targets and is similar
to many other phenolic ...
RedOrbit - Jul
17, 2009
The study, published in the journal Menopause, found
curcumin
-- a component of the spice turmeric -- delayed the first appearance,
decreased incidence and ...
Explain that vitamin D and
curcumin helped stimulate
macrophages, part of the immune system response. Note that macrophages
typically clear plaques in ...
Examiner.com - Jul
17, 2009
... together with a chemical found in turmeric spice
called curcumin, may help stimulate the immune system to clear the
brain of amyloid beta, ...
United Press International -
Jul 16, 2009
"We hope that vitamin D3 and
curcumin, both
naturally occurring nutrients, may offer new preventive and treatment
possibilities for Alzheimer's disease,"
...
In a recent study from UCLA and UC Riverside, researchers
found that vitamin D, combined with curcumin - a chemical found in
the spice turmeric, ...
Curcumin is found in the curry spice, turmeric.
Together with properties of vitamin D (D3), they may help stimulate the
immune system to clear the brain of ...
HealthJockey.com - Jul
16, 2009
Now it seems that the
curcumin chemical found in
turmeric, along with a form of vitamin D (vitamin D3) may be useful in
clearing away amyloid plaques found ...
Personal Liberty Digest - Jul
15, 2009
One of the groups also received supplementation of 500 mg
of curcumin, a polyphenol found in turmeric, per 1 kg of food. The
researchers found that the mice ...
Atlanta Journal Constitution -
Jul 15, 2009
... when combined with a chemical found in a spice
called curcumin, may help stimulate the immune system to clear the
brain of amyloid beta. ...
The active ingredient in turmeric that makes it such a
great medical tool is called curcumin.
Curcumin has been
found to be a powerful anti-inflammatory and
...
Science Daily - Jul
15, 2009
"We hope that vitamin D3 and
curcumin, both
naturally occurring nutrients, may offer new preventive and treatment
possibilities for Alzheimer's disease,"
...
COLUMBIA — MU researchers have found that
curcumin,
an Indian spice derived from the turmeric root, could potentially reduce
the risk of ...
Researchers found that a common spice in Asian food,
curcumin,
prevents breast cancer in many rats treated with hormone replacement
medications. ...
Both paprika (Capsicum annuum) and turmeric (Curcuma longa)
contain irritants (capsaicin and curcumin, respectively) that can
cause irritation to the skin, ...
Curcumin (derived from the spice turmeric),
quercetin (a kind of plant pigment), and a host of other food-derived
chemicals, vitamins, and herbal products
...
Smash Hits - Jul
14, 2009
Researchers have now found that
curcumin, a popular
Indian spice derived from the roots of turmeric, could cut down the risk
of cancer in women who take to ...
Times of India - Jul
14, 2009
WASHINGTON:
Curcumin, a popular Indian spice derived
from the turmeric root, can help reduce cancer risk among postmenopausal
women exposed to hormone ...
... apigenin from celery and parsley,
curcumin
from turmeric, epigallocatechin-3-gallate (EGCG) from green tea,
resveratrol from red grapes and peanuts,
...
The scientists looked at chemical compounds analyzed in
research papers and found that some, such as
curcumin, which is
found in the curry ingredient ...
According to Dr. Michael Roizen, the best supplements are
DHA, Vitamin D, Tomato sauce and mustard (curcumin). Some top herbs
- according to "medicine ...
Turmeric's effective compound,
curcumin is both a
powerful anti-inflammatory and antioxidant and is used to treat arthritis
in India. ...
Fiji Times - Jul
2, 2009
The key ingredient is
curcumin, a component of the
spice turmeric. Curcumin appears to prevent the spread of amyloid
protein plaques - thought to cause ...
Examiner.com - Jul
2, 2009
Curcumin: The herb turmeric contains
curcumin,
a substance that can block substance P from sending pain messages to the
brain. A suggested dose is 400 to ...
goodtoknow - Jun
29, 2009
A study published in the Journal Of Nutrition found that
curcumin,
the major ingredient in turmeric, could inhibit the development of fat
cells. ...
Calgary Herald - Jun
29, 2009
... on the ancient Indian medicine system, Ayurveda,
which have combined curcumin from turmeric and antioxidants with a
surprisingly short ingredient list. ...
Turmeric has
curcumin and will help to stimulate
bile flow in the liver and can help protect the liver from the dangers of
toxins. ...
Or you could try consuming
curcumin, a compound
found in the spice turmeric, a staple of some Asian diets. Test your
knowledge of curcumin with this quiz.
...
Inventorspot - Jun
27, 2009
Professor Murali Doraiswamy at Duke took mice that had
these brain plaques and fed them large amounts of
curcumin, a curry
spice contained in the turmeric ...
Merinews - Jun
27, 2009
We recommend JIVA fermented soy and herbal spice
nutritional beverage, which contains the highest quality non-GMO fermented
whole soy protein, curcumin C3
...
South Bend Tribune - Jun
23, 2009
According to a study in the May issue of the Journal of
Nutrition, curcumin could stall the spread of fat tissue by: a)
inhibiting new blood vessel growth; ...
Daily Kos - Jun
21, 2009
In this pandemic unfolding in our midst, although a mild
one for now and sharing with you the virtues of
Curcumin and Herbs
today I will share results of ...
Examiner.com - Jun
20, 2009
Curcumin may provide an inexpensive, well-tolerated,
and effective treatment for inflammatory bowel disease (IBD) such as
Crohn's and ulcerative colitis, ...
But it's actually
curcumin in turmeric, the cause of
the yellow colour, that interests scientists. Dr. Bharat Aggarwal,
professor of cancer research at the ...
Examiner.com - Jun
16, 2009
Turmeric (Curcumin) – Turmeric is a spice common
in Indian foods. It is gold or yellow and gives the food a vibrant color.
Much research has been done on ...
BlueRidgeNow.com - Jun
16, 2009
... 2009 and 2006; Dr. Rosenfeld (Parade, June 19,
2005) “now” agrees. n Eat high levels of fruits, vegetables,
antioxidants, Co-Q-10, green tea, curcumin, etc.
This ability was shown by the other tested compounds in the
declining order of curcumin, cinnamaldehyde, piperine, allyl
sulphide, and quercetin. ...
Herbs such as green tea extract and
curcumin are now
frequently added to the daily multivitamin/mineral formula. They are among
many phyto-chemicals that ...
Food Consumer - Jun
13, 2009
The research, by Professor Murali Doraiswamy from Duke
University, showed diets high in curcumin (found in turmeric)
helped dissolve amyloid protein plaques
...
There is a “magic” component in curry called
curcumin
that has been shown to decrease the risk of getting Alzheimer's and
dementia. ...
Times of India - Jun
12, 2009
This would seem unlikely, with similar effects reported for
other components of wine and for other natural products such as
curcumin.
...
Curcumin, a component of turmeric, that's used in
curries, appears to prevent the spread of amyloid protein plaques, which
are suspected to cause dementia, ...
Online - International News Network -
Jun 10, 2009
His team would like to try giving
curcumin to women
who know they have a high risk of breast cancer -- such as those who have
a mother or sister with the ...
Online - International News Network -
Jun 10, 2009
Tests in mice showed that
curcumin, an active
compound found in turmeric, helped stop the spread of breast cancer tumor
cells to the lungs. ...
Times of India - Jun
6, 2009
WASHINGTON: Turmeric curry once or twice a week could
keep Alzheimer's disease and dementia at bay, thanks to a magic
ingredient curcumin found in the spice
...
Private Healthcare UK - Jun
6, 2009
... claimed that eating curry twice a week can
help reduce the risk of developing Alzheimer's disease, thanks to the
properties of the key ingredient curcumin.
Private Healthcare UK - Jun
5, 2009
In particular, the team of scientists believes that
curcumin,
which helps to make up the spice tumeric, works to prevent the spread of
amyloid protein ...
According to Prof Doraiswamy, who grew up in Madras, the
magic ingredient in curry is curcumin, a component of the spice
turmeric. ...
U.S. News & World Report - Jun
5, 2009
It's long been believed that
curcumin -- the main
ingredient in turmeric -- is responsible for its healing power, but it
hasn't been known how curcumin
...
NewsMax.com - Jun
5, 2009
Murali Doraiswamy, director of the mental fitness
laboratory at the Duke University Medical Center's psychiatry
department, told a conference that curcumin,
...
meatinfo.co.uk - Jun
5, 2009
US researchers have found that
curcumin - an
ingredient in popular curry spice tumeric - blocks the spread of amyloid
plaques, the toxic protein deposits ...
It contains a substance called
curcumin, which is
useful in disbanding amyloid protein plaques in the brain, which are
responsible for dementia. ...
Jakarta Post - Jun
4, 2009
... ranging from those whose color will fade
quickly, such as curcumin, to those whose color will become
stronger over time, such as alizarin and moridin.
...
Stop Aging Now - Jun
4, 2009
By Carey Rossi
Curcumin, the natural pigment that
gives the curry spice turmeric its yellow color, has developed quite an
impressive reputation for it ...
Mail on Sunday - Jun
4, 2009
According to Professor Murali Doraiswamy, the magic
ingredient is curcumin, a component of the spice turmeric.
Curcumin
prevents the spread of harmful ...
Ozarks First - Jun
4, 2009
The key ingredient in curry is
curcumin, a
component of the spice turmeric. The ingredient appears to prevent the
spread of amyloid protein plaques in the
...
Southside Times - Jun
4, 2009
You eat the ancient, yellow, healing spice, also called
curcumin,
every day in mustard, curry and cheese. It flavors and colors milk
drinks, dairy products, ...
Little About - Jun
4, 2009
What is
curcumin? Well,
curcumin is an
ingredient in turmeric. It has the competence to prevent changes in the
brain by blocking the spread of amyloid
...
Curcumin, a component of turmeric, a spice often
used in curries, appears to prevent the spread of amyloid protein
plaques in the brain. ...
The Spoof (satire) - Jun
4, 2009
"In the past we thought
curcumin, a component
of the spice turmeric was responsible. We believed that
curcumin
prevented the spread of amyloid protein
...
Hospital Healthcare Europe - Jun
4, 2009
Indian-born US expert Professor Murali Doraiswamy said
part of the spice turmeric - called curcumin - prevents changes
in the brain linked to the disease by
...
The Publican - Jun
4, 2009
A study is being carried out on
curcumin, which is
found in turmeric. Scientists at the University of California believe it
destroys plaques that build up ...
Diet Blog - Jun
4, 2009
A Tufts University study has found that
curcumin,
a polyphenol found in turmeric, has shown promise as a weight loss
aid...in mice. ...
Andhra Cafe - Jun
4, 2009
iStudies in
America have already produced strong evidence that
curcumin
combats dementia and that a clinical trial
...
Mirror.co.uk - Jun
3, 2009
Scientists at the University of California believe it
destroys plaques that build up on nerve cells and stop them
communicating. ...
TheMedGuru - Jun
3, 2009
Curcumin, a component of spice turmeric, appears
to foil the spread of these amyloid protein and thus, wards off
dementia, noted Professor Murali Doraiswamy
...
HealthCentral.com - Jun
3, 2009
The key ingredient in curries--curcumin--is a
component of the spice turmeric, which has been shown to help prevent
the formation of beta-amyloid plaques in
...
The Press Association - Jun
3, 2009
A clinical trial is now under way in California to test
the effects of the agent, curcumin, on a group of Alzheimer's
patients. ...
Curcumin, a component of turmeric, appears to
prevent the spread of amyloid protein plaques, which are suspected to
cause dementia, Murali Doraiswamy of ...
Best of Times - Jun
2, 2009
These include rosemary, broccoli, olives, ground
flaxseed, probiotics, cat's claw, curcumin, omega 3 fatty acids,
ginger, N-acetylcysteine, spirulina and
...
Examiner.com - Jun
2, 2009
Recent research is turning up promising information about
curcumin, an active component of the herb turmeric. Oxidative
stress is a significant factor in ...
Irish Central - Jun
1, 2009
Curcumin, found in the curry spice turmeric,
possesses potent antioxidant and anti-inflammatory properties. It's
known that long-term users of ...
Shreveport Times - Jun
1, 2009
Other LSU Health Sciences Center researchers are studying
the anti-cancer effects of curcumin, resveratol and ginger, all
natural substances. ...
Daily Mail - Jun
1, 2009
Turmeric contains a plant-based chemical called
curcumin
which is easily absorbed by the body, according to a study from Tufts
University in Boston. ...
HealthJockey.com - May
31, 2009
Curcumin, the key polyphenol in turmeric, seems to
also aid in restraining the growth of fat tissue in animal models. This
added advantage of turmeric was ...
Sarasota Herald-Tribune - May
28, 2009
Ginger and
curcumin, a component of the spice
turmeric, found in curries and some yellow mustards, help ward off
infection. While being out in the world
...
Voice of America - May
25, 2009
Several years ago, scientists in Singapore investigated
curcumin,
from the curry spice turmeric. The scientists based their study on earlier
evidence that ...
Green Right Now - May
18, 2009
By Barbara Kessler You've already heard about how
curcumin,
or turmeric, may help reduce your chances of getting Alzheimer's, a
disease that is virtually ...
Science Daily (press release) - May
18, 2009
ScienceDaily (May 18, 2009) —
Curcumin, the major
polyphenol found in turmeric, appears to reduce weight gain in mice and
suppress the growth of fat tissue ...
Chemical & Engineering News - May
18, 2009
One potential source for such a drug is
curcumin,
the polyphenolic yellow-orange curry spice derived from the turmeric
plant. Schubert's group is working on ...
Science News - May
15, 2009
In biochemistry, Anartya Mandal of Brighton, Mass., won for
research into inhibiting cancer cells with
curcumin. Ronit Abramson
of San Diego won in cellular ...
The Patriot Ledger - May
13, 2009
Nutrients, such as vitamin C,
Curcumin (the spice
Tumeric), Vitamin B-12, and selenium assist in glutathione production. All
can be obtained from a healthy ...
ProHealth - May
12, 2009
We investigated the effect of
curcumin, the major
polyphenol in turmeric spice, on angiogenesis, adipogenesis,
differentiation, apoptosis [programmed cell
...
Allston-Brighton TAB - May
12, 2009
... the Genzyme Science Award as the Fair's Grand
Prize recipient for his project entitled “Curcumin Induces
Apoptosis in Cancer Cells by Inhibiting NF-kB”.
...
Morganton News Herald - May
12, 2009
For decades, we've known that the yellow pigment in
turmeric, called curcumin, exerts potent antioxidant and
anti-inflammatory effects in cells and animals.
...
North Attleborough Free Press - May
7, 2009
... the Genzyme Science Award as the Fair's Grand
Prize recipient for his project entitled “Curcumin Induces
Apoptosis in Cancer Cells by Inhibiting NF-kB.
...
Natural News.com - May
6, 2009
Curcumin is the essential ingredient of turmeric. It
enhances bile flow as well as DNA repair enzymes. He also recommends
Taurine, an amino acid that ...
Natural Products Industry Insider - May
6, 2009
BOSTON—Findings from a recent study at Tufts University
suggest dietary curcumin may have a potential benefit in preventing
obesity (J Nutr. ...
Somerville Journal - May
6, 2009
Linda Chau and Lola Yu — Comparison of the Effects of
Curcumin
versus Chemotherapeutic Drugs, team, second place. Sarah Hassan — The
Effects of Fertilizer ...
It has an active ingredient called
curcumin that has
shown resistance to colon, breast, liver, oral, skin, and stomach tumors
in laboratory testing on ...
Brain protection: Antioxidant activity of
curcumin
(pigment in turmeric) has been shown to be neuro-protective. Studies show
may be beneficial in treatment ...
TheMedGuru - Apr
25, 2009
In some previous studies, researchers have found that
curcumin,
a main ingredient in turmeric, contains many medicinal properties
including ...
Whilst many researchers in recent years have conducted
research on its main constituent ‘curcumin', no details had been
discovered as to how curcumin works
...
Natural Products Industry Insider - Apr
23, 2009
COLLEGE STATION, Texas—Results from a study at Texas
A&M University suggest combination chemotherapy (omega-3s +
curcumin
or limonin) may favorably modulate ...
Reader's Digest - Apr
22, 2009
Why you should try it: Small studies have found that
curcumin,
a component of turmeric, cuts cholesterol; animal research suggests it
inhibits tumor ...
Mangalorean.com - Apr
22, 2009
Although modern scientific research on the spice has
burgeoned in recent years, scientists until now did not know exactly how
curcumin
works inside the body ...
Daily News & Analysis - Apr
21, 2009
While many scientists have conducted research on its main
ingredient--curcumin--no details had been revealed as to how it
functions in the body, until now. ...
SmartBrief - Apr
21, 2009
Curcumin, the yellow component of the turmeric
spice, reduces inflammation and might help relieve symptoms for people
suffering from inflammatory bowel ...
Natural Products Industry Insider - Apr
21, 2009
BOSTON—Findings from a study at Tufts University suggests
dietary curcumin may have a potential benefit in preventing obesity
(J Nutr. 2009;139(5):919-25). ...
Times of India - Apr
21, 2009
An international team has carried out the study and found
that curcumin, the major yellow constituent of turmeric, helps in
reducing inflammation in many ...
Science Daily (press release) - Apr
20, 2009
Although modern scientific research on the spice has
burgeoned in recent years, scientists until now did not know exactly how
curcumin
works inside the body ...
Inquirer.net - Apr
20, 2009
... bean sprouts, alfalfa, radish, wheatgrass, oat
bran, wheat bran, rice bran, ginger, horseradish,
curcumin from
turmeric, capsaicin from red hot chili,
...
Stuff.co.nz - Apr
19, 2009
Researchers at Nutrigenomics New Zealand have found that
curcumin,
the major yellow component of the turmeric spice, reduces inflammation for
those ...
Science Daily (press release) - Apr
19, 2009
For example,
curcumin can undermine certain TLRs
when a specific part of curcumin's chemical structure reacts with
what are known as "sulfhydryl groups" in
...
NewDesignWorld (press release) - Apr
18, 2009
One thing that all the scientists agree upon is the fact
that the curcumin oil is the compound responsible for making it so
bio active. ...
About - News & Issues - Apr
16, 2009
Scientists have shed new light on how
curcumin—a
compound found in the curry spice turmeric—can help guard cells against
all kinds of disease-promoting ...
Natural Products Industry Insider - Apr
16, 2009
WINSTON-SALEM, NC—According to a study published
Carcinogenesis, curcumin may exhibit organ-specific effects to
enhance reactive oxygen species formation in
...
Christian Post - Apr
14, 2009
Turmeric root (or
curcumin), Tart cherry and Holy
basil leaf (not the common herb basil) have all been used for centuries as
pain-killers and ...
Agricultural Research - April
8, 2009
For example,
curcumin can undermine certain tlrs
when a specific part of curcumin's chemical structure reacts with
what are known as "sulfhydryl groups" in
...
The National - Apr
3, 2009
The researchers have also been working with another natural
resource: curcumin, the active ingredient of turmeric. “Looking
into existing living resources ...
Modern Medicine - Apr
2, 2009
THURSDAY, April 2 (HealthDay News) -- The ability of
curcumin,
an antioxidant from turmeric, to reduce liver fibrosis in patients with
non-alcoholic ...
Examiner.com - Mar
31, 2009
These include red clover, ashwagandha, and
curcumin.
Broccoli sprouts contain indole-3-carbinol, a component of broccoli and
other members of the Brassica ...
ColorsNW - Mar
30, 2009
The most widely researched alkaloids found in turmeric are
the curcuminoids: curcumin, demethoxy-curcumin and
bisdemethoxy-curcumin.
...
Brain Blogger - Mar
28, 2009
The active ingredient in turmeric is called
curcumin.
Antioxidant and free radical scavenging capacity of
curcumin is on
par with vitamin C and E, ...
FreshPlaza - Mar
24, 2009
In a recent study conducted at Michigan University, it was
found that curcumin, the bright yellow pigment present in turmeric,
can help boost cell health by ...
Reader's Digest - Mar
22, 2009
Because of its anti-inflammatory properties, scientists are
studying curcumin, one of the most active substances in turmeric,
as a possible treatment for ...
Boston Globe - Mar
22, 2009
The resveratrol phenomenon has created a "parallel
interest in other substances, such as curcumin," said Douglas
MacKay, a licensed naturopathic doctor in
...
DL-Online - Mar
20, 2009
Turmeric, whose active ingredient is
curcumin, is
most effective when combined with black pepper and olive oil during
cooking. ...
American research revealed in 2006 that
curcumin, a
chemical found in curry ingredient turmeric, may help the body clear the
protein that causes the brain ...
The Canberra Times - Mar
17, 2009
Turmeric - a vivid yellow spice which adds colour and
antioxidants due to its curcumin with research showing it may delay
dementia. ...
Depok Metro - Mar
17, 2009
Dr. Whitaker suggests a daily supplement regimen: DHA, 50
mg (3-4 fish oil capsules); Curcumin, 900-1800 mg; Natural vitamin
E,800-1600 IU; Vitamin C,3000 ...
Manila Bulletin - Mar
16, 2009
Evidence suggests that
curcumin, the bright yellow
compound in turmeric, may help inhibit the growth of cancer cells, reduce
inflammation, and safeguard the ...
spectroscopyNOW.com - Mar
14, 2009
Solid state NMR has been used to help to explain why
curcumin,
one of the physiologically active components of the yellow spice turmeric
has wound healing ...
sScienceDaily.com - Mar
8, 2009
University of Michigan researchers led by Ayyalusamy Ramamoorthy have
discovered that curcumin acts as a disciplinarian, inserting itself
into cell membranes and making them more orderly, a move that improves
cells' resistance to infection and malignancy.
Best Life Magazine - Mar
5, 2009
Curcumin, a chemical in turmeric, helps deter the
accumulation of amyloid plaques in the brain, tiny blockages that may cause
Alzheimers disease ...
Seattle Times - Mar
2, 2009
A component,
curcumin, has powerful
anti-inflammatory activity, and, preliminary studies suggest, some benefit
for psoriasis. One reader wrote: "I took
...
Dr. Whitaker suggests a daily supplement regimen: DHA, 50
mg (3-4 fish oil capsules); Curcumin, 900-1800
Tulsa World - Feb
21, 2009
These include rosemary, broccoli, olives, ground flaxseed,
probiotics, cat's claw, curcumin, omega 3 fatty acids, ginger,
N-acetylcysteine, spirulina and ...
What's
hot about curry?
University Daily Kansan, KS -
Feb
4, 2009
She says many studies found anti-inflammatory and anti-cancer
properties in curcumin, a substance found in turmeric. Curry
addicts anonymous: Vaishali Gala, ...
|
5
Reasons I Wish I Liked Turmeric
Beliefnet.com, NY -
Feb
4, 2009
The
curcumin in turmeric (the thing that gives it its
orange-yellow color) may have powerful anti-inflammatory and
anti-cancer properties (see this article)
...
|
Curry
some flavor to reduce inflammation
Pioneer Press Online, IL -
Jan
29, 2009
The key Alzheimer's-fighting spice in curry powder is turmeric, whose
main chemical is curcumin. A pigment in
curcumin gives
turmeric its yellow color. ...
|
Pancreatic
Cancer, Tumeric and Omega-3
Cancer Monthly, NC -
Jan
25, 2009
A recent study in the journal Nutrition and Cancer finds that
curcumin—a
compound in turmeric—halts the growth of pancreatic cancer,
particularly when ...
|
Tailoring
autism therapies
Worcester Telegram, MA -
Jan
25, 2009
He also uses a glutathione cream that is supposed to detoxify his
body, a B-12 cream, an intestinal complex to help with digestion, fish
oils, curcumin and
...
|
The
You Docs tips for the week
Telegraph-Journal, Canada -
Jan
24, 2009
The food: Curry The magic:
Curcumin, a substance found in the
Indian spice turmeric, may help quell the muscle inflammation that you
know as next-day ...
|
Natural
Help for Ovarian Cancer
Natural News.com, AZ -
Jan
23, 2009
Tumeric (found in the common spice
Curcumin) has been shown to
be effective against a wide variety of cancers, including ovarian, and
is meriting more and ...
|
Are
your painkillers killing you?
phillyBurbs.com, PA -
Jan
21, 2009
Curcumin, found in turmeric, is another natural compound that
reduces inflammation. You can sprinkle it on a variety of foods or get
it in supplement form. ...
|
Food
secrets for staying slim
Trinidad News, Trinidad and Tobago -
Jan 20, 2009
When they fed obese mice
curcumin, the yellow-orange
antioxidant in turmeric, there was a decline in the animals’ body
weight and fat, even with higher ...
|
Here's
a brainy idea - how about a little music?
Toronto Star, Canada -
Jan
20, 2009
The magic:
Curcumin, a substance found in the Indian spice
turmeric, may help quell the muscle inflammation that you know as
next-day stiffness and soreness ...
|
Trying
Anything and Everything for Autism
New York Times, United States -
Jan 20, 2008
He also uses a glutathione cream that is supposed to detoxify his
body, a B-12 cream, an intestinal complex to help with digestion, fish
oils, curcumin and
...
|
Spice
It Up with Ground Realities
TheMedGuru, India -
Jan
18, 2009
Curcumin is the compound present in Turmeric, which lends the
spice its yellow color. This active compound is believed to assist
body in fighting against ...
|
Medical
management of NMSCs
Modern Medicine, NJ -
Jan
18, 2009
Down the road, dermatologists can expect to see
curcumin,
lycopene, T4 endonuclease, cox-2 inhibitors, DFMO and polyphenolic
antioxidants added to this ...
|
Fruits
and Vegetables in Cancer Prevention
Insciences Organisation, Switzerland -
Jan 16, 2009
Evidence indicates that some food compounds, such as soy isoflavones
and curcumin, can increase the effectiveness of chemotherapy
and radiation therapy. ...
|
Evidence
Update
ADVANCE for LPNs, PA -
Jan
15, 2009
... such as antioxidants and vitamin B complex (especially
folate), omega-3 polyunsaturated fatty acids, the polyphenol
curcumin
and other nutraceuticals. ...
|
Today’s
Foods May Be Tomorrow’s Medicines
Food Product Design, IL -
Jan
15, 2009
A single plant molecule can have an array of health-promoting effects,
Curcumin, obtained from the spice turmeric, not only protects
against cancer but is ...
|
Herbs
and Spices Boost Health
NewsMax.com, FL -
Jan 15,
2009
The active ingredient in turmeric,
curcumin, is an extremely
powerful anti-inflammatory substance. It may play a role in combating
cancer and reducing the ...
|
The
cures in your kitchen
New Zealand Herald, New Zealand -
Jan 12, 2009
A single plant molecule can have a bewildering array of
health-promoting effects - curcumin, for example, obtained from
the spice turmeric, doesn't only ...
|
Eat
antioxidants
USA Today -
Jan 12, 2009
Piles of evidence show that antioxidant-packed spinach, broccoli,
pomegranate juice, dark chocolate, garlic, onions, tea, coffee, purple
grapes, red wine and the spice turmeric cut disease risk.
...
|
Turmeric
helpful in anti-cancer drugs
Times of India, India -
Jan
8, 2009
Series of researches conducted in the last five years by MS
University's pharmacy department on animals have revealed that green
tea leaf and curcumin help
...
|
:
The Top 10 Health Breakthroughs of 2008
NewsReleaseWire.com (press release) -
Jan 6, 2009
This year scientists demonstrated that fish oil, blueberries,
curcumin,
and pantethine all help boost the production of BDNF. Running is now
proven to be ...
|
STEVE
JOBS' WASTING-AWAY HEALTH PROBLEM
NewsWithViews.com, OR -
Jan
5, 2009
Top choices include grape seed extract, fish oil, bromelain, papain,
curcumin,
quercetin, silymarin, and r-alpha lipoic acid. These nutrients not
only help ...
|
Turmeric
Boots The Brain
Bottom Line Health Secrets -
Dec 27,
2008
Curcumin (turmeric’s active ingredient) is one of the most
potent, naturally occurring anti-inflammatory agents ever identified
and thus may be one of the best all-round spices for disease
protection and antiaging.
|
Alzheimer's:
Prevent It With Nutrition?
PWO, France -
Dec 27,
2008
Dr. Whitaker suggests a daily supplement regimen: DHA, 50 mg (3-4 fish
oil capsules); Curcumin, 900-1800 mg; Natural vitamin
E,800-1600 IU; Vitamin C,3000 ...
|
Turmeric
may work for Alzheimer’s
Times of India, India -
Dec
18, 2008
Researchers at the University of Southampton are investigating whether
curcumin found in turmeric — that gives curries the yellow
colour — could benefit ...
|
Curry
'linked to Alzheimer's treatment'
Barchester Healthcare, UK -
Dec
18, 2008
The Alzheimer's Society is investigating the effects of
curcumin
- a component of turmeric, a popular Indian spice - on those with the
disease. ...
|
Alzheimer’s
Society
Look To The Stars, UK -
Dec
17, 2008
In over 250 locations across the UK, Alzheimer’s Society staff and
volunteers work together to provide help and information to people
affected by dementia ...
|
Turmeric
may lower blood pressure
Indianapolis Star, United States -
Dec 15, 2008
Answer: Rodent research suggests that
curcumin, the active
ingredient in turmeric, can lower blood pressure (Journal of Clinical
Investigation, March 2008). ...
|
People's
Pharmacy: Help for fungal infections
Houston Chronicle, United States -
Dec 14, 2008
We don’t think doctors will prescribe curry, but rodent research
suggests that curcumin, the active ingredient in turmeric, can
lower blood pressure ...
|
Golden
therapy
Hindu, India -
Dec 13,
2008
Low rates of Alzheimer’s among rural Indians first drew the
attention of western researchers to
curcumin. The most likely
reason for this dramatic ...
|
Curcumin
an Effective Anticancer Agent
PR Urgent -
Dec 13, 2008
Curcumin is derived from turmeric fingers.
Curcumin act
as a powerful antioxidant, anti tumors, anti inflammatory agent etc
keeps the body away from disease ...
|
Curry
Treats Parkinson’s Disease
NewsMax.com, FL -
Dec 1,
2008
Researchers at Johns Hopkins Medicine have found that
curcumin,
the spice used in curries, eases the symptoms of Parkinson’s
disease. ...
|
How
to prevent Alzheimer’s disease – part 1
Food Consumer, IL -
Nov
21, 2008
Spice your food with curry:
Curcumin, a component of curry and
turmeric, seems to help the immune system get rid of amyloid beta --
the protein that builds ...
|
Cancer
survivor credits healthful diet
Denver Post, CO -
Nov 16,
2008
"But if you take the phytochemical
curcumin found in the
Indian spice turmeric — which hits over 70 targets — you might get
different results," Block said.
...
|
Eat
it: 6 foods that ward off aging
Lansing State Journal, MI -
Nov
16, 2008 -
Filter
Curry powder: It's full of the antioxidant
curcumin, which
wards off Alzheimer's disease by preventing the growth of amyloid
plaques, which are toxic to ...
|
Want
to Avoid Alzheimer’s?
NBC Washington, DC -
Nov
3, 2008
The UCLA group hypothesized that
curcumin, a chemical in
turmeric, might clean up or block the buildup of amyloid plaques,
which scientists believe may ...
|
Add
spice, reap benefits
The Daily Evergreen, WA -
Nov
2, 2008
Studies have linked consumption of
curcumin, the active
ingredient in tumeric, to benefits ranging from preventing heart
failure to slowing the progression ...
|
Eat
Smart Add turmeric to your food
USA Weekend -
Oct 31, 2008
Turmeric contains
curcumin, a powerful antioxidant dubbed
"curecumin" by leading researcher Bharat Aggarwal of the
University of Texas MD Anderson Cancer
...
|
Turmeric
Reduces Size of Stroke
India Journal, CA -
Oct
30, 2008
Scientists at the US-based Medical College of Georgia are using animal
models to study effects of turmeric or
curcumin on
intracerebral haemorrhages. ...
|
Ten
immune system-boosting foods
abc13.com, TX -
Oct 30,
2008
Turmeric is found in every yellow curry and its golden color is
primarily the result of curcumin, a polyphenol with strong cold
and flu-fighting properties. ...
|
Spice
In Indian Food May Help Fight Cancer
WJZ, MD -
Oct 28, 2008
Healthwatch reporter Kellye Lynn talked to a researcher at Johns
Hopkins who says curcumin could slow the spread of cancer.
Scientists in Baltimore are ...
|
Fresh
cancer treatment
Sunshine Coast Daily, Australia -
Oct 25, 2008
But if you take the phytochemical
curcumin found in the Indian
spice turmeric – which hits more than 70 targets – you might get
different results. ...
|
NIH
Botanical Center Research Update
Natural Products Industry Insider, AZ -
Oct 24, 2008
... outlined his team's the focus and goals relative to five
botanicals—Echinacea, astragalus, curcumin, coriolus mushroom
and maitake mushroom. ...
|
Spice
up your immune system
The Silhouette, Canada -
Oct
23, 2008
In recent years,
curcumin, the active component of turmeric,
has been highly studied for its incredible medicinal and healing
properties. ...
|
Our
Favorite Winter Squashes
Stop Aging Now, DC -
Oct
22, 2008
This Curried Butternut Soup recipe has anti-inflammatory,
brain-protecting curcumin in the curry powder, lots of
antioxidant beta-carotene and good amounts
...
|
Curry
Cuisine
Trinidad News, Trinidad and Tobago -
Oct 22, 2008
Many people with arthritis take over-the-counter supplements that
contain curcumin, the active ingredient in turmeric. Curry also
may offer some protection ...
|
6
foods that ward off aging
Kansas City Star, MO -
Oct
20, 2008
•Curry powder: It’s full of the antioxidant
curcumin, which
wards off Alzheimer’s disease by preventing the growth of amyloid
plaques, which are toxic to ...
|
The
quest for cancer-preventing drugs
Los Angeles Times, CA -
Oct
20, 2008
Folic acid, vitamin D, selenium, lycopene, the spice ingredient
curcumin,
green tea and resveratrol, a compound found in red grapes, all are
being tested in ...
|
Having
a problem? Check your kitchen
Sunday Times.lk, Sri Lanka -
Oct
18, 2008
Turmeric contains a compound called
curcumin which is a
powerful anti-inflammatory as well as antioxidant. Today,
investigators at the University of ...
|
Spice
extract may help stroke victims
LubbockOnline.com, TX -
Oct
14, 2008
Curcumin is the plant chemical that makes the spice tumeric
yellow, and tumeric is a frequent ingredient in curry powder. It is
also the focus of stroke ...
|
Decreasing
belly fat
Examiner.com -
Oct 13, 2008
-Turmeric is a ginger-like plant with the active ingredient of
curcumin
which helps to reduce weight gain. Turmeric can be found in beverages,
ice cream, ...
|
An
Anticancer Diet
Daily News Central, NV -
Oct
12, 2008
... turmeric (one of the main spices in curry) has been found
to contain the most potent natural antiinflammatory ever described --
the molecule "curcumin.
...
|
Protect
all your vital organs
The Post, Pakistan -
Oct
11, 2008
Lab experiments in the past have shown that
curcumin - the
yellowish component of the Indian curry spice turmeric - is able to
fight skin, breast and other ...
|
Turmeric
can prevent diabetes-induced blindness
Hindu, India -
Oct 10,
2008
Lab experiments in the past have shown that
curcumin - the
yellowish component of the Indian curry spice turmeric - is able to
fight skin, breast and other ...
|
Turmeric
may Reduce Hemorrhagic Stroke Size
Medi News Direct, India -
Oct
7, 2008
Curcumin, a principal component responsible for the yellow
color in the Indian spice turmeric, has been previously suggested to
possess anticancer ...
|
Feeding
your body's defenses against cancer
Daily Camera, CO -
Oct 6,
2008
"But if you take the phytochemical
curcumin found in the
Indian spice turmeric -- which hits over 70 targets -- you might get
different results," Block said
...
|
Foods
to keep us all going strong
Philadelphia Daily News, PA -
Oct
2, 2008
_ Double dose of spice: Turmeric contains a compound called
curcumin
that may help keep the brain young. Turmeric also may improve memory.
...
|
Study
Finds Cancer Survivors' Health Greatly Enhanced With Vitamin
...
Natural News.com, AZ -
Sep
23, 2008
One cancer survivor I know would add DIM, beta glucan, vitamin C
complex, vitamin D3, niacin, magnesium,
curcumin, tocotrienols,
sulforaphane and quercetin ...
|
6
foods that ward off aging
Dallas Morning News, TX -
Sep
23, 2008
Curry powder: It's full of the antioxidant
curcumin, which
wards off Alzheimer's disease by preventing the growth of amyloid
plaques, which are toxic to ...
|
Yerba
Mate: South America's Health Drink
Natural News.com, AZ -
Sep
21, 2008
Other compounds that inhibit angiogenesis and are active as
chemopreventive agents, such as curcumin, also inhibit
proteasome activity. ...
|
Editorial:
Cancer demands our attention
Shreveport Times, LA -
Sep
19, 2008
It includes Dr. Shile Huang who received $720000 from the American
Cancer Society for research into the spice
curcumin and its
potential as an anti-cancer ...
|
Food
for thought
Scugog Standard Newspaper, Canada -
Sep 12, 2008
The active ingredient in turmeric is ‘curcumin,’ which has
been shown to inhibit and slow cancer growth. It is a powerful
anti-oxidant, ...
|
Turmeric
improves flavor and health
Suffolk News-Herald, VA -
Sep
10, 2008
I learned that Turmeric is the yellow spice in mustard and curry and
that its active ingredient is curcumin. It usually can be found
on spice shelves in ...
|
Go
on, spice up your life -- you'll like it
Orlando Sentinel, FL -
Sep
9, 2008
A: Turmeric is a spice found in curry powder that gets its yellow
color from a pigment called curcumin. In fact, says the IFIC,
curcumin
is used as a spice ...
|
Painkiller
on Your Kitchen Shelf
RedOrbit, TX -
Sep 7,
2008
In fact,
curcumin has been found to be every bit as effective
as the pharmaceutical drugs cortisone and phenylbutazone in clinical
trials. ...
|
Cure
cancer with diet?
SheKnows.com, AZ -
Sep 7,
2008
... turmeric (one of the main spices in curry) has been found
to contain the most potent natural anti-inflammatory ever described
– the molecule "curcumin".
...
|
Feeding
your body's defenses against cancer
PhysOrg.com, VA -
Sep 2,
2008
"But if you take the phytochemical
curcumin found in the
Indian spice turmeric - which hits over 70 targets - you might get
different results," Block said.
...
|
Turmeric
May Help Reduce Type 2 Diabetes Risk
ABC News -
Sep 1, 2008
In obese mice, turmeric significantly reduced inflammation in fat
tissue and the liver and reduced the rodents' susceptibility to type 2
diabetes. The researchers believe curcumin -- an ingredient in
turmeric -- may be responsible ...
|
|
Taking
care before and after surgery
North Island Midweek, Canada -
Sep
1, 2008
Another remedy I use with good success is a natural anti-inflammatory
composed of a mixture of bromelain,
curcumin and quercitin.
...
|
Reverse
aging
Delicious Living Magazine, Coloarado -
Sep 1, 2008
Curcumin, a naturally occurring chemical in the spice, slows
down the aging process by fighting inflammation-causing proteins
called cytokines. ...
|
Spices
add a dash of health to dishes
Chicago Tribune, United States -
Aug 31, 2008
... curry powder is a blend of turmeric and other spices.
Curcumin,
the bright yellow pigment in turmeric, helps fight heart disease and
may boost brain health.
|
A-to-Z
Buyer's Guide
RedOrbit, TX -
Aug 26,
2008
The active ingredient in the herb is
curcumin. Some supplements
contain turmeric while others contain
curcumin, extracted from
the whole herb. ...
|
Alzheimer's:
Prevent It With Nutrition?
Corsavoo.com, France -
Aug
20, 2008
Dr. Whitaker suggests a daily supplement regimen: DHA, 50 mg (3-4 fish
oil capsules); Curcumin, 900-1800 mg; Natural vitamin
E,800-1600 IU; Vitamin C,3000 ...
|
Spice-based
compound may kill cancer cells
United Press International -
Aug
18, 2008
Assistant Professor James Fuchs said the synthetic molecules are
derived from curcumin, a naturally occurring compound found in
the spice turmeric. ...
|
On
nutrition: Spice up your life
The Olympian, WA -
Aug
15, 2008
A: Turmeric is a spice found in curry powder that gets its yellow
color from a pigment called curcumin. In fact, says the IFIC,
curcumin
is used as a spice ...
|
Prevent
Memory Loss with Diet
Stop Aging Now, DC -
Aug
13, 2008
Those with the strongest supporting evidence: green tea, fish oil,
gingko, alpha lipoic acid, curcumin, and acetyl-l-carnitine.
The Anti-Aging Bottom Line: ...
|
Wellness
in a Minute: Benefits of antioxidants
The Evening Sun, PA -
Aug
10, 2008
The main ingredient in curry is turmeric, from which a spice called
curcumin
is derived. Sally Frautschy, Ph.D., a researcher from UCLA who has
done ...
|
Breast
cancer: What you need to know
Food Consumer, IL -
Aug
5, 2008
Turmeric:
Curcumin in turmeric, a yellow spice widely used in
Indian cuisine, has long been touted for its health benefits. A study
recently found that ...
|
Many
herbs make move to medicine cabinet
MLive.com, MI -
Aug 5,
2008
Turmeric, the spice that gives curry powder its yellow color, has an
active ingredient called curcumin, which appears to inhibit
enzymes that lead to ...
|
Good
News About Curry
13WHAM-TV, NY -
Jul 31,
2008
Curcumin, the natural yellow pigment in curry, has been shown
to improve symptoms of diabetes in mice. Researchers say they noticed
a significant drop in ...
|
A
Spicy Diet May Help Diabetics
Christian Broadcasting Network, VA -
Jul 31, 2008
"After two weeks of consuming
curcumin orally, their
diabetes was essentially gone." The results suggested that
curcumin,
which is found in turmeric, ...
|
Oprah
Winfrey Show
Oprah.com -
July, 2008
Dr. Mehmet Oz says the secret to good mental health may be on
Indian spice racks. "The reason we think they have a lower
instance of Alzheimer's isthey use a lot of turmeric in their
food," he says. Turmeric is an orange-yellow spice that's
commonly used to make curries. Its active ingredient is called
curcumin.
...
|
Food
for thought
Economist.com -
July,
2008
Another polyphenol,
curcumin, has also been shown to have
protective effects. It reduces memory deficits in animals with brain
damage. It may be no coincidence that in India, where a lot of
curcumin
is consumed (it is the substance that makes turmeric yellow),
Alzheimer’s disease is rarer than elsewhere.
...
|
|
Turmeric
may help prevent type 2 diabetes
Food Consumer, IL -
Jul
27, 2008
They speculate that
curcumin found in turmeric may be the
active ingredient that lessens insulin resistance and prevents type 2
diabetes in the mice by ...
|
YourHealth:
Fat head and the fishy truth
New Straits Times, Malaysia -
Jul
26, 2008
Omega-3 fatty acids as well as
curcumin, a compound present in
the spice turmeric, can help elevate BDNF in a manner similar to
antidepressant or ...
|
Cognition
nutrition Food for thought
Economist, UK -
Jul 17,
2008
Another polyphenol,
curcumin, has also been shown to have
protective effects. It reduces memory deficits in animals with brain
damage. ...
|
Tobacco
Researchers in Oklahoma Receive Grants
RedOrbit, TX -
Jul 16,
2008
... of biochemistry and molecular biology at Oklahoma State
University, Expression Profile of MicroRNAs in Cells Treated with
Cigarette Smoke and Curcumin.
|
Curry
ingredient fights skin cancer
Online - International News Network, Pakistan -
Jul 12, 2008
They said
curcumin, found in the spice turmeric, interferes
with melanoma cells. Tests in laboratory dishes show that
curcumin
made melanoma skin cancer ...
|
The
You Docs tips for the week
Telegraph-Journal, Canada -
Jul
12, 2008
Curcumin, a compound in turmeric, shows promise against cystic
fibrosis, colon cancer, arthritis, Alzheimer's... and even the
discomfort of post-workout ...
|
Fight
Diabetes with Curcumin
Stop Aging Now, DC -
Jul
11, 2008
By Carey Rossi A recent study found that diabetics who supplemented
with curcumin for six weeks experienced significant
improvements in insulin resistance ...
|
Balanced
Diet Helps Maintain
Oneindia, India -
Jul 11,
2008
The researcher also said that the high consumption of
curcumin,
found in the India curry spice turmeric, might help prevent
Alzheimer''s disease and brain ...
|
Turmeric
packs surprisingly flavourful punch
Times Colonist, Canada -
Jul
9, 2008
According to an article in the Wall Street Journal titled Common
Indian Spice Stirs Hope, research into
curcumin, the active
ingredient in turmeric, ...
|
Clams
we dig
Daytona Beach News-Journal, FL -
Jul 8, 2008
At a dinner last month at the restaurant to unveil the recipe, DeSilva
praised the active ingredient in the spice,
curcumin, as an
anti-inflammatory, ...
|
Fresh
Fat Facts
Keep the Doctor Away, UK -
Jul
8, 2008
... makes you less susceptible to developing Type 2 diabetes
– probably because of curcumin, an anti-inflammatory,
anti-oxidant ingredient in turmeric.
...
|
Sheriff
takes to the saddle for Hope
Melton Today, UK -
Jul 5,
2008
Projects Hope has funded include investigations into the preventative
effects of food derivatives such as berries,
curcumin, rice
bran and tea; ...
|
Spice
up your health with turmeric
SheKnows.com, AZ -
Jul 3,
2008
Thanks to
curcumin, the active ingredient in turmeric that has
powerful anti-inflammatory and antioxidant components, the researchers
say turmeric may treat ...
|
Indian
Gold
MensHealth.com -
July, 2008
For decades, researchers have searched for an immunity superbooster
that could hold back the tide of disease. In the spice markets of the
Far East, they may have found it..."It's mind-boggling,"
says Dr. Aggarwal. "Turmeric is safe, and as far as the
number of diseases it addresses, you name it. It truly has the
potential of being a wonder spice."
...
|
"95
percent turmeric extract" supplement at turmeric-curcumin.com
Health.msn.com -
July, 2008
In the Western world, researchers have long suspected
Curcuma
longa to be more than just a sunburst-yellow spice that doubles as a
home remedy. But only in recent years have they become sufficiently
intrigued to look beyond folklore and subject
turmeric to the
rigors of 21st-century science."...
|
Turmeric
hope for diabetics
Hindu, India -
July 01,
2008
Tortoriello claims that
curcumin, an anti-inflammatory,
anti-oxidant ingredient found in Turmeric (Curcuma longa) can
significantly reduce insulin ...
|
US
data reveals 24m diabetes sufferers
NutraIngredients-usa.com, France -
Jun 25, 2008
... linked to diabetes benefits in studies published over the
past two months alone include pine bark extract, canola protein, cocoa
flavanols and curcumin.
...
|
6
ways to spice up your diet
Dallas Morning News, TX -
Jun
24, 2008
Curry powder: Turmeric, an ingredient in curry powder, contains
curcumin.
This phytochemical helps thwart cancer by switching off proteins that
cause cells ...
|
Feeling
fat worse than actually being fat
The Post, Pakistan -
Jun
24, 2008
They speculate that
curcumin, the anti-inflammatory,
anti-oxidant ingredient in turmeric, lessens insulin resistance and
prevents Type 2 diabetes in these ...
|
Health
Highlights: June 23, 2008
Forbes, NY -
Jun 23, 2008
The researchers believe
curcumin -- an ingredient in turmeric
-- may be responsible, United Press International reported. The study
was presented at the ...
|
Curry
Spice Could Prevent Diabetes and Obesity
Keep the Doctor Away, UK -
Jun
23, 2008
But the researchers say that stocking up on Turmeric makes you less
susceptible to developing Type 2 diabetes – probably because of
curcumin,
...
|
The
cancer - inflammation link
Edmonton Sun, Canada -
Jun
23, 2008
For example, many studies have shown that the anti-inflammatory
activity of curcumin, found in the Indian spice turmeric, or
even gingerol, found in ginger, ...
|
What's
the alternative?
Times Online, UK -
Jun
21, 2008
The rates of Alzheimer’s are much lower among the elderly in India
than in the West, and early studies show that
curcumin, an
antioxidant phytochemical ...
|
Turmeric
may help prevent diabetes, obesity
DailyIndia.com, FL -
Jun
20, 2008
Researchers from Columbia University Medical Centre have found that
curcumin,
the anti-nflammatory, anti-oxidant ingredient in turmeric can
significantly ...
|
Dr.
Sandy: Spicy Love
NBC5.com, IL -
Jun 19,
2008
Tumeric is a main ingredient in curries and chemical;
curcumin
in turmeric gives the curry powder and gives it that bright yellow
color. ...
|
Counting
on curcumin
Livemint, India -
Jun 16,
2008
The researchers are trying to find out if
curcumin works in
fighting HPV. It will be available as a vaginal tablet or cream. The
pilot project of a clinical ...
|
Turmeric
innovations report, Germany -
Jun
11, 2008
At the moment, he has named this creme "Microencapsulation of
Curcumin
and Turmeric Oil Extracted from Turmeric and Application in Cream
Preparation". ...
|
fast
food friendlies
The Sun, UK -
Jun 10,
2008
The turmeric used in many Indian dishes contains super-nutrient
curcumin
which is packed with anti-oxidants and is said to lower the risk of
bowel cancer. ...
|
Cancer
prevention: the natural way
News-Medical.net, Australia -
Jun
10, 2008
... products resveratrol (contained in grapes, red wine, nuts
and berries), curcumin (contained in turmeric-curry) and tricin
(contained in wild rice). ...
|
Breaking
News from The Plain Dealer
The Plain Dealer - cleveland.com, OH -
Jun 10, 2008
Its active ingredient is
curcumin, used for centuries in
traditional medicine to treat ailments from gallstones to anemia, to
heal wounds and treat ...
|
Today's
health tip
Ithaca Journal, NY -
June
2, 2008
New evidence suggests that its active ingredient,
curcumin,
might prevent or treat some diseases. The National Institutes of
Health is recruiting patients ...
|
SciDev.net
SciDev.net, UK -
May 29,
2008
The yellow colouring agent in turmeric,
curcumin, inhibits
cancer cell proliferation by interfering with the activity of several
key proteins involved in ...
|
How
to keep Alzheimer's at bay
Times of India, India -
May
28, 2008
Ballard also emphasised the protective effects of
curcumin
which is found in turmeric, saying, "Studies show that
curcumin
may protect nerve cells and thus ...
|
Healthy
ways to spice up your life
Trinidad News, Trinidad and Tobago -
May 28, 2008
This bright yellow curry spice gets its colour — and health benefits
— from a compound called curcumin. Scientists believe
curcumin
may lessen muscle ...
|
Turmeric
may help in fighting psoriasis
Indianapolis Star, United States -
May 26, 2008
Answer: There is growing interest in turmeric and its active
ingredient, curcumin, for treating a variety of inflammatory
conditions, including psoriasis. ...
|
Turmeric
offers lots of health benefits
Food Consumer, IL -
May
25, 2008
By Sue Mueller Scientists have found
curcumin, the active
ingredient in the traditional herbal remedy and dietary spice
turmeric, possesses a wide range of
...
|
Promising
breast cancer results
TheChronicleHerald.ca, Canada -
May 15, 2008
Turmeric, a spice widely used in Indian and South Asian cooking,
contains a phytochemical called curcumin, which has been
demonstrated to prevent tumour ...
|
A
Plan for Living a Long and Healthy Life
Natural News.com, AZ -
May
6, 2008
Turmeric (or
curcumin) - This is one of the really important
ones! A highly potent cancer fighter that recent tests have indicated
protects cigarette ...
|
Curcumin
may helps fight diabetes
Food Consumer, IL -
May
1, 2008
By David Liu, Ph. D. WEDNESDAY April 30, 2008 (Foodconsumer.org) --
Curcumin
found in turmeric may help fight diabetes, according to a new study
published ...
|
Natural
Remedies for Treating Arthritis
Natural News.com, AZ -
Apr
18, 2008
Curcumin has been shown to be as effective as cortisone or
phenylbutazone in certain models of inflammation.
Curcumin also
exhibits many beneficial effects ...
|
Plants
That Protect Us
Southwest News-Herald, IL -
Apr
25, 2008
The ARS scientists first reported in 2006 about the ability of
carnosol from rosemary; curcumin from turmeric; resveratrol
from grapes; and ellagic acid, ...
|
Baby
Boomers Redefining Food
Sun-Sentinel.com, FL -
Apr
24, 2008
Double dose of spice: Turmeric contains a compound called
curcumin
that may help keep the brain young. Older adults in Singapore who ate
turmeric-rich curry ...
|
Diets
are a-changin'
The News-Press, FL -
Apr
21, 2008
Turmeric contains a compound called
curcumin that may help keep
the brain young. Cinnamon appears to have insulin-like properties that
may help control ...
|
The
misery of arthritis
Fortnightly Tenerife News, Spain -
Apr 13, 2008
Curry – turmeric contains a powerful ingredient,
curcumin,
which is thought to help both types of arthritis and seems to work by
preventing a protein from ...
|
Spice
up your life and live longer too
Sowetan, South Africa -
Apr
3, 2008
The main chemical in turmeric is
curcumin, which is thought to
slow the progression of certain neuro-degenerative diseases. Most
recently, it has shown ...
|
Protect
Yourself from Harmful Toxins
Stop Aging Now, DC -
April
2, 2008
Curcumin (turmeric) inhibits cancer-causing chemicals like
benzopyrene (found in charcoal-broiled meat) and can neutralize toxic
compounds from cigarette ...
|
March
is Colon Cancer Prevention Month
Pacifica Tribune, CA -
Mar
26, 2008
According to researchers from Wake Forest University School of
Medicine, Curcumin, from the spice turmeric, is now being used
in human clinical trials for ...
|
A
Curry a Day Keeps The Doctor Away
ShortNews.com, Germany -
Mar
25, 2008
The active ingredient
curcumin was given to mice and will
eventually be trialled on humans.Dr Maral Ouzounian says "it is
still a leap to suggest using ...
|
Find:
New line of beneficial teas
Dallas Morning News, TX -
Mar
25, 2008
Curcumin, turmeric's main active component, is a powerful
antioxidant. Dr. Weil adds at least 100 percent of the daily value for
vitamin C to each 8.2-ounce ...
|
Shake
On Oregano, Shake Off Disease?
Sun-Sentinel.com, FL -
Mar
20, 2008
Curcumin, a component of turmeric, may assist the immune system
in fighting the proteins that cause plaque in the brain of Alzheimer's
patients. ...
|
Hot
new research is helping curry fight cancer
The West Australian, Australia -
Mar 16, 2008
Curcumin, which gives curry its yellow colouring and has been
used in Eastern medicine for many years, is said to have powerful
anti-cancer and ...
|
Fighting
Alzheimer’s
Hindu, India -
Mar 15,
2008
Adding a lot of turmeric into curries cooked can help as
curcumin
present in turmeric has shown benefit in some studies. Supplementing
B6, B12 and folic ...
|
Arthritis
and Joint Deterioration
Black Hills Today, SD -
Mar
14, 2008
Turmeric contains
curcumin and related compounds known as
curcuminoids, which have good antioxidant properties. Manganese is
required for enzymes involved ...
|
Power
foods
Detroit Free Press, United States -
Mar 14, 2008
Double dose of spice: Turmeric contains a compound called
curcumin
that may help keep the brain young. Cinnamon appears to have
insulin-like properties that ...
|
Science
Fair students tackle challenges
Connecticut Post, CT -
Mar
13, 2008
... explains her project, "Analysis of Spice
Curcumin",
to judge Mona Nolde, at the Connecticut Science Fair at Quinnipiac
University in Hamden. ...
|
Curry
may cut cardiovascular risks
The News-Press, FL -
Mar
10, 2008
By ROBERT PREIDT • HealthDay • March 11, 2008
Curcumin, an
ingredient in the curry spice tumeric, can reduce heart enlargement
and may lower the risk of ...
|
Natural
Ways to Prevent Alzheimer’s Disease
Stop Aging Now, DC -
Mar
10, 2008
New research suggests that
curcumin, found in turmeric, the
main spice in curry, can stop the build-up of destructive beta-amyloid
protein in the brain ...
|
Curry
is a heart-healthy
SheKnows.com, AZ -
Mar 6,
2008
One of the newest heart-friendly compounds,
curcumin, an
ingredient in the curry spice turmeric, has been found to lower the
risk of heart failure and ...
|
It
Was Then That I Curried You
The Simon, CA -
Mar 5,
2008
It contains
curcumin, which suppresses tumor growth. This is
great news for a cancer-phobic spice enthusiast. This past weekend, I
opened a little tub of ...
|
Curcumin
could be good for your heart
Chicago Tribune, United States -
Mar 4, 2008
Curcumin, an ingredient in the curry spice turmeric, can reduce
heart enlargement and might lower the risk of heart failure, say
researchers at Toronto ...
|
Spice
of life?
York Region Era Banner, Canada -
Mar 3, 2008
Researchers found when the ingredient, called
curcumin, was
given orally to mice with enlarged hearts, the compound served to
prevent and reverse ...
|
Curry
Spice May Thwart Heart Failure
CBS News, NY -
Feb 26,
2008
(WebMD)
Curcumin, an ingredient in the curry spice turmeric,
may help prevent heart failure. That's according to two new studies
done on rats, not people. ...
|
Breast
cancer: What you need to know (1)
Food Consumer, IL -
Feb
23, 2008
Food packaging chemical bisphenol A linked to breast cancer Turmeric:
Curcumin
in turmeric, a yellow spice widely used in Indian cuisine, has long
been ...
|
Supplementing
growth
Express Pharma, India -
Feb
21, 2008
... as a source of ‘essential’ selenium; Glucosamine for
arthritic care and Curcumin from turmeric as an anti-oxidant in
the US Pharmacopoeia," says Bammi.
...
|
Haldi,
that wonder drug
Deccan Herald, India -
Feb
18, 2008
Significantly, research work done in India has hinted at the
anti-cancerous properties of curcumin, an active component of
turmeric. Curcumin is also known
...
|
25
Ways to Keep a Heart Healthy
Best Syndication, CA -
Feb
16, 2008
Include anti-inflammatory herbs and spices such as
curcumin and
ginger. They work in the same way as anti-inflammatory drugs. 12.
...
|
Study
catches picture of deadly cancer enzyme
Scientific American -
Feb 13,
2008
... some natural products can affect cancer.
Curcumin,
the compound that makes the spice turmeric yellow, has been shown in
studies to interfere with p300/CBP.
|
Stressed
Out? You're Not Alone
Christian Broadcasting Network, VA -
Feb 8, 2008
This herb is also known as
curcumin and is a powerful
anti-inflammatory. Thus, it can help alleviate the damage that comes
from stress. ...
|
All
about Alzheimer's disease
PRESS TV, Iran -
Feb 6,
2008
Herbs such as Butcher's broom, Ginkgo biloba extract, Kava Kava,
Curcumin,
rosmarinic acid, the Chinese herb (qian ceng ta) and valerian root are
effective ...
|
Studies
claim turmeric may lower cancer risk
The News-Press, FL -
Feb 5, 2008
Animal studies are now being conducted using the
ingredient curcumin, the active ingredient in turmeric.
Curcumin
only makes up about 3-5 percent by weight
...
|
Indian
Daal: Heart-healthy food
Kalamazoo Gazette - MLive.com, MI -
Feb 1, 2008
Turmeric contains
curcumin, which has been
shown by researchers to help with heart health and acts as an
anti-inflammatory. Packed with antioxidants
...
|
A
Lifesaving Legacy
Newsweek -
Jan
30, 2008
These include substances like ellagic acid (berries),
resveratrol (grapes), curcumin (turmeric), ECGC (green tea),
procyanidin (cocoa) and genistein ...
|
Pain
Management: It's Foods and Not a Drug
Huffington Post, NY -
Jan 14, 2008
The reasons for adding them are included: The bright
yellow pigment of this spice has the ingredient
curcumin.
Studies have shown that it has many
...
|
Herbal
Medicines For Dermatitis
American Chronicle, CA -
Jan 8, 2008
Borage oil, Evening Primrose oil, Flax oil, B-complex,
DMG (B15), B12, Calcium, Magnesium and Potassium (pH adjustment),
Quercetin, Curcumin, Bromelain,
...
|
The
Alarming Increase In Double Mastectomies
Newstarget.com, Taiwan -
Jan 1, 2008
It has also been found that by getting
curcumin
in your system, if you have cancer, this is just as or more effective
in destroying cancer cells than ...
|
Super
ideas for your plate
MiamiHerald.com, FL -
Dec 25, 2007
It contains
curcumin, which has many reported
health benefits including being an anti-inflammatory and a possible
treatment for irritable bowel syndrome.
...
|
PEOPLE'S
PHARMACY
Houston Chronicle, United
States - Dec 16, 2007
It may contain other natural compounds in addition to
curcumin,
the active ingredient in turmeric. More than 150 scientific articles
have been published ...
|
Health
Watch: Babies know who’s naughty or nice
MetroWest Daily News, MA -
Dec
1, 2007
That's because turmeric, a spice used in curry, contains
curcumin,
a powerful anti-inflammatory that works similarly to Cox-2 inhibitors,
drugs that reduce ...
|
Coming
soon to a supermarket near you
Vancouver Sun, Canada -
Nov
21, 2007
The new spice to watch for is
curcumin, the compound that makes
the Indian spice tumeric a dark yellow.
Curcumin has recently
been shown to reduce risk of ...
|
The
Latest News About Alzheimer’s
Parade Magazine -
Nov 21, 2007
Then there is the fascinating observation that an ingredient present
in curry, curcumin, may be beneficial. This may, in part,
explain the relatively low ...
|
Turmeric
use
Daily Press, VA -
Nov 21,
2007
A component of turmeric,
curcumin, has anti-inflammatory as
well as antioxidant activity and shows promise against psoriasis and
other conditions (Annals of ...
|
In your kitchen
Independent, UK -
Nov 20,
2007
A single plant molecule can have a bewildering array of
health-promoting effects – curcumin, for example, obtained
from the spice turmeric, doesn't only
...
|
Curry
in a healthy hurry
Malaysia Star, Malaysia -
Nov
10, 2007
RECENTLY, turmeric (curcumin), a bright yellow coloured curry
spice in Asian cooking has been grabbing the headlines for its ability
to prevent many ...
|
Turmeric
back in the fight against cancer
News-Medical.net, Australia -
Nov
7, 2007
Curcumin, the yellow component in turmeric that gives curry its
flavour, is thought to have the ability to suppress tumours and people
who eat a lot of ...
|
Curry
Could Treat Colorectal Cancer
Associated Content, CO -
Nov
5, 2007
Curcumin, the yellowish component of turmeric has long been
identified as an anti cancer agent, but has yet to be applied in any
meaningful way to treat the ...
|
Turmeric
healed her psoriasis
Los Angeles Times, CA -
Nov 5, 2007
Curcumin,
a component of turmeric, has anti-inflammatory as well as antioxidant
activity and shows promise against psoriasis and other conditions. ...
|
Spice
as remedy tantalizes
News & Observer, NC -
Oct 31, 2007
One of those substances is an antioxidant called
curcumin.
Curcumin
is being studied for possible uses in the treatment of Alzheimer's and
Parkinson's ...
|
Nutrition
tips to help prevent cancer
MSNBC -
Oct
31, 2007
Recent studies show that
Curcumin, the yellow spice found in
Tumeric and Curry Powder, may have anti tumor compounds that can
protect against breast cancer. ...
|
A
spice
separationsNOW.com
(subscription), UK -
Oct 14, 2007
When its rhizomes are boiled for several hours and
dried, they yield a deep orange-yellow substance known as turmeric or
curcumin,
which is used as a food ...
|
Fight
arthritis with these foods
MSNBC - October 11, 2007
Turmeric, sometimes called
Curcumin, is a mustard-yellow spice
from Asia. It is the main ingredient in yellow curry. Scientific
studies have shown that ...
|
Great
global grazings
Ottawa Citizen, Canada -
Oct
6, 2007
"Turmeric's active ingredient is
Curcumin," says
Peacock. "It has many anti-inflammatory, antioxidant, antiviral
and antibacterial properties, among others.
...
|
Spices
prevent fatal diseases
The Post, Pakistan -
Oct
3, 2007
Researchers have found that a substance known as
Curcumin that
is found in turmeric has anti-inflammatory properties. Turmeric can be
used alone and is ...
|
Add
Color To Your Diet
Tyler Morning Telegraph, TX -
Sep
18, 2007
Curcumin is a flavonoid in tumeric, the yellow spice in curry
powder. It inhibits the growth of stomach cancers and other cancers.
Genistein is a flavonoid ...
|
Turmeric
May Guard Against Childhood Leukemia
PakTribune.com, Pakistan -
Sep
10, 2007
Our studies show that Turmeric and its coloring principle,
Curcumin
in the diet mitigate the effects of some of these risk
factors," Nagabhushan said .
...
|
Eat
rainbow colored foods
Frost Illustrated, IN -
Sep
4, 2007
A pigment called
Curcumin gives curry its distinctive yellow
color and has been credited with cancer prevention. I would suggest
that to stay healthy, ...
|
Couple
Research
Tyler Morning Telegraph, TX -
Sep 2, 2007
She also studies the prostate cancer preventative effects of
Curcumin
(the yellow substance in curry spices). Dr. Srivastava investigates
resveratrol, ...
|
The
skinny on spicy foods
MSNBC -
Aug 26, 2007
The
Curcumin that turns Turmeric yellow also helps reduce
inflammation and aids muscle repair after heavy exercise,
researchers at the University of South
...
|
Common
spice may help Alzheimer's patients
Scientific American Magazine -
August 17, 2007
Further studies are needed to determine if increasing blood levels of
macrophages using an oral Curcumin agent clear the amyloid
plaques, ... |
Natural
Herbs For Asthma Treatment
American Chronicle, CA -
Jul
8, 2007
The active constituents are the diarylhepanoids, including
Curcumin,
which are found in the vividly yellow rhizome. In an uncontrolled trial
in India, ... |
Cancer
Pain Management
Journal of American Medical Association
(subscription), IL -
Jul 3, 2007
They discuss medications such as intravenous ketamine, intravenous
lidocaine, and cannabis, and describe the use of herbs and supplements
such as Curcumin
... |
6
ways to spice up your diet
Dallas Morning News
(subscription), TX -
Jun 26, 2007
Curry powder: Turmeric, an ingredient in curry powder,
contains Curcumin. This phytochemical helps thwart cancer by
switching off proteins that cause cells
... |
Adjust
diet for pet with cancer
Arizona Daily Star, AZ -
Jun 26, 2007
... DMG (a nutrient found in grains and meat),
garlic, Curcumin, and medicinal mushrooms are often prescribed.
I'd use this regimen for about six months.
... |
Malaria
drugs failed? Turn to Turmeric
Newindpress (subscription), India -
Jun 19, 2007
Curcumin, a compound isolated from the Turmeric
plant, has been found to possess qualities that can effectively fight
malarial parasites, including the ... |
Forget
fluoride - try Turmeric
Auckland stuff.co.nz, New
Zealand - Jun 12, 2007
"This is due to its active ingredient,
Curcumin,
which has antioxidant and anti-inflammatory properties." Dr Pahuja
contacted the Central Leader to promote
... |
Add
Spices to Your Life
Better Homes and Gardens -
Jun 10, 2007
This spice, which gives ballpark mustard its yellow
color, contains Curcumin, a compound that's been researched for
its potent anti-inflammatory activity.
... |
Healthy
herbs and spices
Lawrence Journal World, KS -
Jun 6, 2007
Its
Curcumin may offer protection against cancer
cells. • How to use it: Add it to rice, eggs or salad dressings. Try
for about 1/8 teaspoon per day, ... |
The
Second Team
USA Today -
May 16, 2007
Research on anti-cancer properties of
Curcumin, a curry extract;
Academic Decathlon president. Daniel Lage, Gulliver Preparatory School,
Miami. ... |
ORAC
and Antioxidants: Realizing the Potential
Natural Products Industry Insider, AZ -
May 4, 2007
For comparison, he offered
Curcumin, which has demonstrated its
antioxidant and health benefits via in vitro, in vivo and clinical
studies. ... |
HealthFirst-What
Causes Alzheimer's
ABC12.com, MI -
May 1, 2007
Researchers say fish, spices like curry and
Curcumin, and certain
juices may reduce the risk. You can see the ABC12 report by clicking on
the video icon ... |
Spice
up your health
Kansas.com, KS -
Apr 23,
2007 Its
Curcumin may offer protection against cancer cells. How to
use it: Add it to rice, eggs or salad dressings. Try for about
1/8teaspoon per day, ... |
Curcumin,
Also Known As Curry Powder, Has Anticancer Effects
Medical News Today (press release) -
Apr
22, 2007
Curcumin, a Turmeric root extract, has been shown to possess
activity in the treatment and prevention of cancer, multiple sclerosis,
and Alzheimer's disease ... |
Curry
Compound May Fight Rare Neurological Illness
CBC News, -
April 1, 2007
FRIDAY, March 30 (HealthDay News) - A synthetic compound that's a
distant chemical relative of a component of
Curcumin - a spice
used to make curry - shows ... |
Curcumin
May Treat Prostate Cancer
Ivanhoe, FL -
Mar 21, 2007
In the most recent issue of Cancer Research, researchers from the
Comprehensive Cancer Center of the University of Alabama in Birmingham
report Curcumin has
... |
12
Myths about Colon Cancer
eMaxHealth.com, NC -
Mar 2,
2007 In the area of prevention, researchers are looking at the effects of
Curcumin
(found in curry), resveratrol (found in red wine), ginger and the
... |
The
Natural Way to Ward Off Alzheimer's Disease
Hornell Evening Tribune, NY -
Feb
27, 2007
Turmeric contains
Curcumin which is used in Ayurvedic medicine
for its antioxidant, anti-inflammatory, anti-carcinogenic, and other
effects. ... |
Spice
it Up: Turmeric
FitSugar.com, CA -
Mar 13,
2007 Its active ingredient
Curcumin, works in a very similar way to
non-steroidal anti-inflammatory drugs. In fact the spice has been used
in Ayurvedic ... |
Advance
reported in fight against muscular dystrophy
Taipei Times, Taiwan -
Mar
6, 2007
A newly developed
Curcumin compound has proven effective against
muscular dystrophy in tests on rodents conducted by a US-based research
team led by a ... |
Health:
Colorectal Cancer Study
CBS 3, PA -
Mar 27, 2007
Hoping to avoid the same fate, Ned joined a study to test a pill made
from an ingredient called Curcumin found in the spice Turmeric.
... |
Eating
right helps give clear skin
NorthJersey.com, NJ -
Feb
28, 2007
Preliminary research shows that
Curcumin, the principle
ingredient in Turmeric, can stop inflammatory processes in the body and
prevent cell damage. ... |
From
garlic to basil to curry, a healthy choice
Salt Lake Tribune, UT -
Feb
12, 2007
Curcumin, commonly found in Turmeric - a yellow-orangish spice
added to curry mixes - has anti-inflammatory properties. * Fight cancer:
Eat more curry. ... |
Colon
cancer polyps reduced by curry and onions
TopCancerNews.com, TX -
Feb
8, 2007
Curcumin is the chemical found in Turmeric and is the key agent
in the pill that the patients were administered. The amount of quercetin
was similar to what ... |
Summer
Holiday Health Essentials
Response Source (press release), UK -
Mar 26, 2007
... entering the tissues) and helps combat circulatory disorders
including varicose veins, and Curcumin is a powerful
anti-oxidant/anti-inflammatory agent.
... |
Fighting
Colds with Spices
6abc.com, PA -
Feb 8, 2007
In addition to its anti-inflammatory properties, research on
Curcumin
has also shown it to shrink pre-cancerous lesions known as colon polyps.
... |
Try
turmeric for psoriasis, digestion
Newsday, NY -
Feb 6, 2007
It contains a compound,
curcumin, that has anti-inflammatory
activity. Several readers have reported that taking turmeric capsules or
putting turmeric on ... |
Spice
up your health
Regina Leader-Post, Canada -
Feb
1, 2007
Research has found
curcumin (the source of the spice turmeric,
which gives curry its characteristic bright yellow colour and strong
taste), ... |
PEOPLE'S
PHARMACY Fiber, fish oil may lower cholesterol
Houston Chronicle, TX -
Jan
28, 2007
It contains a compound,
curcumin, that has anti-inflammatory
activity. Several readers have reported that taking turmeric capsules or
putting turmeric on ... |
Turmeric
wards off Alzheimer's, cancer
NDTV.com, India -
Jan 26,
2007 Turmeric contains a powerful substance called
curcumin, which
shields the brain from the damage that leads to Alzheimer's. In 1989,
Bharat Aggarwal, ... |
Help
With Nail Fungus, Intestinal Gas, High Cholesterol
Hartford Courant, CT -
Jan
26, 2007
A. Turmeric contains a compound,
curcumin, that has
anti-inflammatory activity. Several readers have reported that taking
turmeric capsules or putting ... |
Simple
steps to reduce the risk
Toronto Star, Canada -
Jan
25, 2007
Spice it up: Turmeric, a spice common in East Indian cooking, contains
curcumin,
which may reduce inflammation in the brain, in turn cutting the risk for
... |
Pass
on the salt in favor of healthier herbs
Ann Arbor News, MI -
Jan
24, 2007
Turmeric's
curcumin also has been shown to shrink precancerous
lesions known as colon polyps. Zick says the amount needed to accomplish
this is unclear, ... |
Turmeric
for skin, digestion
Los Angeles Times, CA -
Jan
27, 2007
It contains a compound,
curcumin, that has anti-inflammatory
activity. Several readers have reported that taking turmeric capsules or
putting turmeric on ... |
Unlocking
the secrets of curcumin
Cochrane Times, Canada -
Feb
7, 2007
My constant perusal of the Lancet, New England Journal of Medicine and
Women's Weekly Digest has convinced me to take three supplements;
curcumin,
... |
Statins:
the truth
Daily Mail, UK -
Jan 29,
2007 Finally, try
curcumin found in the spice turmeric.
Curcumin
has been found to reduce the stickiness of platelets in the blood and
relax arteries. |
Spices
of life
Sun-Sentinel.com, FL -
Jan
10, 2007
Curcumin is the compound found in turmeric, a key ingredient in
curry powder that provides its distinctive yellow hue. But
curcumin
adds much more than just ... |
Healthier
eating can begin with spices
Earthtimes.org -
Jan 10, 2007
In addition to its anti-inflammatory properties, research on
curcumin
has also shown it to shrink pre-cancerous lesions known as colon polyps.
... |
Curry
- a spicy treatment for malaria
Jamaica Gleaner, Jamaica -
Jan
7, 2007
Investigators are finding that
curcumin has a wide range of
powerful and useful properties. Here's the low-down on some of the most
promising research to ... |
Spice
up your food for a healthier diet
Zee News, India -
Jan 7,
2007 In addition to its anti-inflammatory properties, research on
curcumin
has also shown it to shrink pre-cancerous lesions known as colon polyps.
... |
Olive
oil may prevent cancer
Business Standard, India -
Jan
7, 2007
Curcumin, an active ingredient in turmeric, garlic, ginger, fish
oil and herbal products like amla, as well as those that belong to the
phyllanthus group of ... |
Good
Diet Includes Herbs
MedIndia, India -
Jan 7,
2007 A substance known as
curcumin found in turmeric has
anti-inflammatory properties.Turmeric can be used alone or added to
curry. Curcumin also shrinks
... |
Boost
Your Health With Spices
Food Consumer, IL -
Jan 6,
2007 Researchers have found that a substance known as
curcumin that is
found in turmeric has anti-inflammatory properties. Turmeric can be used
alone, ... |
Study
looks at intravenous gene therapy
Science Daily (press release) -
Nov 8,
2006 ... During Radiation Therapy For Cancer (October 8, 2002) -- Cancer
researchers at the University of Rochester Medical Center have found that
curcumin,
a substance ... |
Health
Alert: Lifelong research
WIS, SC -
Nov 7, 2006
... commitment. Doctor Carmen Guerra hopes
curcumin, a substance
found in the Indian spice turmeric, can help prevent colon cancer.
... |
Changing
minds in Alzheimer's research
Los Angeles Times, CA -
Nov 5, 2006
... A number of promising experiments are underway, including the work
of Greg Cole, a professor of medicine and neurology at UCLA, on the use of
curcumin,
a spice ... |
Analysis:
Ancient medicine useful today
United Press International -
Nov 2, 2006
... condition. Today, turmeric dietary supplements are marketed as
curcumin,
the chemical that gives turmeric its yellow color. It's
... |
Curry
may protect brain
Orlando Sentinel, FL -
Nov 1, 2006
New research suggests that an ingredient found in curry -
curcumin -
might prevent the tangled clumps of protein found in the brains of Alzheimer's
patients. ... |
Turmeric
helps stave rheumatoid arthritis
United Press International -
Oct 31,
2006 ... been used for centuries by practitioners of Ayurvedic medicine to
treat inflammatory disorders, and the extract containing the ingredient
curcumin
is marketed ... |
Curry
Good For Your Brain
ABC News -
Oct 26, 2006
... standard tests.
Curcumin, found in the curry spice turmeric,
possesses potent antioxidant and anti-inflammatory properties. It's
... |
Curcumin
helps clear Alzheimer's plaques
United Press International -
Oct 4, 2006
4 (UPI) --
Curcumin -- in curry and turmeric -- may help the immune
system clear the brain of amyloid beta, the plaques found in Alzheimer's
disease, says a US ... |
New
Therapies
WSOCtv.com, NC -
Nov 11, 2006
... When comparing diets, one particular compound sparked Guerra's
interest - curcumin, an ingredient found in the spice Tumeric, that's
used to make curry and ... |
Supplements
get spicy
Wilkes Barre Times-Leader, PA -
Nov
7, 2006 ... Animal studies have found that
curcumin, one of the active
ingredients in turmeric, inhibits the growth of cancers. And
curcumin
... |
The
Health Benefits of Turmeric
WTMJ-TV, WI -
Nov 8, 2006
You could move to India or just increase your intake of
Curcumin.
Curcumin
is the natural pigment that gives the spice turmeric its yellow color.
... |
You
can be too thin
USA Weekend -
Nov 3, 2006
... booster. The secret:
curcumin, an antioxidant shown to improve
memory in animals and reduce a brain toxin that's linked to Alzheimer's.
... |
Turmeric
Prevents Experimental Rheumatoid Arthritis, Bone Loss
...
Medical News Today (press release), UK -
Nov
3, 2006 ... Turmeric extract containing the ingredient
curcumin is
marketed widely in the Western world as a dietary supplement for the treatment
and prevention of a ... |
Boost
Memory and Protect Against Alzheimer's
SeniorJournal.com, TX -
Nov 2, 2006
... October 5, 2006 – In a small test with senior citizens – age 65
to 84 – researchers found that curcumin — a chemical found in curry
and turmeric ... |
Lifelong
Research
CBS 5 - Green Bay, WI -
Nov 1, 2006
In Many Cases.. Advances In Science Require A Lifelong Commitment. Doctor Carmen
Guerra Hopes Curcumin.. A Substance Found In The Indian Spice Tumeric..
... |
UA
study: Turmeric root stops arthritis
Tucson Citizen, AZ -
Nov 1, 2006
... The study by Dr. Janet L. Funk and Barbara N. Timmermann provides the
first "in vivo" documentation of how extracts containing
curcumin
protect against ... |
Curry
spice 'help for arthritis'
Health Sentinel -
Oct 31, 2006
... And it was this extract, containing
curcumin, that was most
effective at blocking the onset of rheumatoid arthritis in the rats.
... |
Curry
spice 'help for arthritis'
BBC News, UK -
Oct 30, 2006
... And it was this extract, containing
curcumin, that was most
effective at blocking the onset of rheumatoid arthritis in the rats.
... |
Curry
Ingredient Turmeric, Helps to Dampen Inflammatory Effects of
...
Nutrition horizon (press release), Netherlands -
Oct 30, 2006
... on rats. Turmeric, which gives curries their characteristic
yellow-orange tinge, is a major dietary source of
curcumin. Turmeric
... |
Curry
may fight Alzheimer's
Health24.com, South Africa -
Oct
30, 2006 Curcumin, a component of curry and turmeric, seems to help the immune
system get rid of amyloid beta - the protein that builds up to form damaging
plaques in ... |
Major
research in cancer treatment
Hindu, India -
Oct 22, 2006
... "For the first time, we showed how
curcumin derived from
turmeric can act as an anti-HPV molecule and how it can be used for treatment of
cervical cancer," Das ... |
Prevention's
Anti-Aging Guide: How To Take Off 10 Years Or More
...
The Ledger, FL -
Oct 13, 2006
... Turmeric, the spice that makes curry yellow, is loaded with
curcumin,
a chemical with potent antioxidant and anti-inflammatory properties.
... |
Spice
up disease-fighting ability
Bradenton Herald, United States -
Oct
7, 2006 ... Turmeric:
Curcumin is the compound found in turmeric, a key
ingredient in curry powder that provides its distinctive yellow hue.
... |
CURRIES
FIGHT ALZHEIMER'S
Mirror.co.uk, UK -
Oct 5, 2006
Scientists discovered that a chemical called
curcumin, which is found
in curry and turmeric, helped the body fight the illness.
... |
Chemical
from Curry Helps Immune System's 'PacMen' Gobble Plaque
...
SeniorJournal.com, TX -
Oct 5, 2006
October 5, 2006 – In a small test with senior citizens – age 65 to 84 –
researchers found that curcumin — a chemical found in curry and
turmeric ... |
Curcumin
could cut plaque build-up linked to Alzheimer’s
NutraIngredients-usa.com, France -
Oct
4, 2006 10/4/2006 -
Curcumin, found extensively in curries, could boost the
body’s ability to clear the build up of plaques in the brain that are linked
to Alzheimer ... |
UCLA/VA
Study Finds Chemical Found in Curry May Help Immune System
...
UC Los Angeles, CA -
October 3,
2006 UCLA/VA researchers found that
curcumin — a chemical found in curry
and turmeric — may help the immune system clear the brain of amyloid beta,
which form ... |
Chemicals
in curry and onions may help prevent colon cancer
Newstarget.com (press release), Taiwan -
Sep
29, 2006 ... form of precancerous polyps in the lower bowel known as familial
adenomatous polyposis (FAP) were treated with regular doses of
curcumin
(the chemical found in ... |
Is
your spice rack also a medicine chest?
Philadelphia Inquirer, PA -
Sep 28,
2006 ... Turmeric.Curcumin is the compound found in turmeric, a key
ingredient in curry powder that provides its distinctive yellow hue.
... |
Curcumin
fights colorectal cancer
Food Consumer, IL -
Sep 22, 2006
By Ben Wasserman. 24 Sept. (foodconsumer.org) -
Curcumin
may be used as a drug to curb the growth and spread of colorectal cancer because
it reduces the ... |
Johns
Hopkins' discoveries in a nutshell
Joplin Independent, MO -
Sep 22, 2006
... studies in populations that consume large amounts of
curry, as well as laboratory research on rodents have strongly suggested that
curcumin,
a relatively ... |
Curcumin
found to fight tumors
Daily News - Galveston County, TX -
Sep 20, 2006
They’ve found that turmeric’s active ingredient,
curcumin,
works in the lab to fight skin, breast and other tumor cells. In
... |
August 2006
In
addition to antiviral, wound-healing, anti-inflammatory, and antioxidant
activity, there’s evidence that
curcumin kills some types of cancer
cells, inhibits oxidation of LDL (“bad”) cholesterol, and may block a
chemical that’s involved in arthritis.
August 2006
Curry and onion extracts could protect against colon cancer.
Quercetin and
curcumin, compounds found naturally in onions and curry,
could reduce the risk of colon cancer, suggests a small clinical trial from the
US.
August 2006
Treatment
Based on Curry and Onions Reduced Precancerous Intestinal Growths.
Although
study participants received the two substances together, the researchers believe
curcumin was the key ingredient. "The amount of quercetin we
administered was similar to what many people consume daily. However, the amount
of curcumin is many times what a person might ingest in a typical diet,
since turmeric only contains on average 3% to 5% curcumin by weight,"
researcher Francis M. Giardiello, MD, of Johns Hopkins University School of
Medicine, says in a news release.
August 2006
Study
Finds Compounds In Curry, Onion May Shrink Colon Polyps. The potential of
curcumin
to prevent and/or treat cancer in the lower intestines surfaced in studies in
lab rats fed curry, as well as in observational studies of Asian populations
that consume a lot of curry.
August 2006
Pills
containing curcumin, a substance found in turmeric (a key ingredient of
curry), and quercetin, an anti-oxidant derived from onions, kept the adenomas at
bay, according to Francis Giardiello, M.D., of Johns Hopkins here. Patients with
familial adenomatous polyposis develop hundreds of adenomas and eventually colon
cancer.
July 2006
Curcumin,
which gives curries their characteristic yellow tinge, is a potent killer of
melanoma cells in vitro. Curcumin, found in the spice turmeric, has been
shown in other studies to both inhibit cancer cell proliferation and encourage
programmed cell death, or apoptosis, in various tumor cell lines, including
multiple myeloma and squamous cell carcinomas.
July 2006
"Tests
in mice showed that
curcumin, an active compound found in turmeric, helped stop
the spread of breast cancer tumor cells to the lungs.
June 2006
"treatment
of cancer patients,
curcumin has been used as capsules and if used in diabetic
retinopathy, the dosage could be much lower."
June 2006
"curcumin
helps thwart cancer by "switching off" proteins that cause cells to
multiply and by inducing cancer cells to self-destruct. The spice may also
reduce risk of Alzheimer's, psoriasis and arthritis.
June 2006
"curcumin,
the active ingredient in turmeric. This Indian spice has been used for centuries
to flavor curry. Recently, scientists have found that this antioxidant compound
fights inflammation and discourages the buildup of amyloid plaques in the brain
(Current Alzheimer's Research, April 2005). Such plaques are characteristic of
Alzheimer's disease.
May 2006
"Curcumin
has also shown great promise in the prevention of cancer. It is the active
ingredient in Tumeric, a type of curry spice. Research has been conducted for
decades now, and it would appear that
Curcumin has extremely powerful
anti-inflammatory, anti-oxidant, and anti-tumor properties. It has also been
shown to interfere with cell-signaling pathways, which works to suppress the
transformation and proliferation of cancerous cells."
April
2006
"Curcumin,
the chemical ingredient found in turmeric – our ubiquitous “safran”
– has been shown to have a double protective effect on the brain through its
anti-oxidation property: it prevents deterioration of the communication among
the cells of the brain (which is fundamental to the memory process) and it slows
or actually prevents the formation of what are called amyloid plaques that are
thought to be related to the genesis of Alzheimer’s disease."
March 2006
"when
colon-cancer cells were exposed to curcumin—the yellow pigment that gives
curry its color—25 percent were destroyed within a day. "Studies have
also shown that curcumin reduces the formation of blood vessels in cancerous
cells and inhibits the cells' movement."
February 2006
Curcumin
is medically promising because inflammation and oxidative damage are
contributors to so many diseases, such as Alzheimer's, Parkinson's, arthritis
and various cancers, said Gregory Cole, a professor of medicine and neurology at
the David Geffen School of Medicine at UCLA who has conducted numerous studies
on the spice. Curcumin are being probed for their potential to
prevent and treat a broad range of diseases: cancer, cystic fibrosis,
Alzheimer's and arthritis.
Researchers believe the Curcumin it
contains fights disease partly by shutting down a powerful protein that promotes
an abnormal inflammatory response in the body. The spice also has potent
antioxidant properties (and may even lower cholesterol).
January
2006
Curcumin
protects against prostate cancer
January 2006
Professor
Bharat Aggarwal is a researcher at the MD Anderson Cancer Centre at the
University of Texas in the United States, where a major focus of his work has
been Curcumin, active component of the distinctive yellow curry spice
turmeric. He said the dietary spices played an important role in fighting
cancer.Masala a day keeps the doctor away.
January 2006
(Consumer
Reports) "Curcumin
has shown promise for several conditions: Alzheimer's disease. Cancer. Cystic
Fibrosis."
November 2005
"Curcumin is a natural product isolated from the spice
turmeric...shown to have antiangiogenic (anti-tumor) properties in vitro and in
vivo".
November 7, 2005
"Curcumin abolishes aberrant enzyme expression in brain tumor
cells."
November 2005
"Elevated MG levels in diabetes patients are believed to contribute to diabetic complications...Curcumin inhibited the MG-stimulated increase...Curcumin
prevented the MG-induced apoptosis...Curcumin significantly reduced the MG-mediated
impairment."
October 25, 2005
"Low rates among Indians for colorectal, prostate and lung cancers as well as coronary heart disease and Alzheimer's first drew Western researchers to
Curcumin. It's a hot topic in health journals, too, cited 967 times since 2000 in articles reported on
PubMed, the National Library of Medicine's research service. It's a promising potential weapon against several cancers, Alzheimer's disease, cystic fibrosis, psoriasis and other
diseases."
October 16, 2005
"Curcumin the main ingredient of turmeric and the compound that gives curry its mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report researchers at The University of Texas M. D. Anderson Cancer
Center."
September 2005
"The DNA synthesis and the cellular growth were inhibited by
Curcumin in dose-dependent manner in all the five malignant astrocytoma cell
lines."
August 2005
"(Curcumin)
showed potent growth inhibitory activity (anti-tumor)."
July 20, 2005
"Curcumin's
promise is enormous as it appears to inhibit multiple pathways by which cancer
grows, and we know it's nontoxic..."Curcumin
affects virtually every tumor biomarker that we have tried"
July 12, 2005
A study published in the upcoming issue of Cancer magazine shows
Curcumin, a chemical pigment in turmeric, has promise fighting breast, colon,
prostate and pancreatic cancers
July 11, 2005
Curcumin, the yellow pigment found in the curry spice turmeric, inhibits melanoma cell growth and kills
tumor
cells, shows a new study
June 9, 2005
The spice turmeric, which is often found in curry powder, contains a chemical that may help stop breast cancer from spreading.
Researchers from the University of Texas M.D. Anderson Cancer Center
May 5, 2005
Researchers
at the Alzheimers Disease Research
Center at UCLA are testing Curcumin's ability to treat the earlty stages
of the disease. The Cystic Fibrosis
Foundation is funding a clinical trial on Curcumin. Scientists at M.D.
Anderson Cancer Center are studying Curcumin
as a possible treatment for multiple myeloma and pancreatic cancer, based on
research showing that it may stop cancer cells from proliferating and cause
malignant tumors to self-destruct
April
1, 2005
Curcumin under human trials for Alzheimer's prevention
February 18, 2005:
Alzheimer's
disease involves amyloid {beta} (A{beta}) accumulation, oxidative damage, and
inflammation, and risk is reduced with increased antioxidant and
anti-inflammatory consumption. The phenolic yellow curry pigment Curcumin
has potent anti-inflammatory and antioxidant activities and can suppress
oxidative damage, inflammation, cognitive deficits, and amyloid accumulation
January 4, 2005:
Curcumin,
the yellow pigment in curry spice, is to be investigated for its potential in prevention
of Alzheimer’s disease
December 29,
2004:
Curcumin, the yellow pigment in curry spice, inhibits the accumulation of destructive beta amyloids in the brains of Alzheimer's patients and also breaks up existing plaques.
December
18, 2004:
Turmeric prevents
cancer, particularly leukemia, say
researchers. Curcumin...may be
responsible for much of this benefit
December 10, 2004:
Scientists
believe that curcumin, a spice used in India and known for its anti-inflammatory
effects, may prevent memory loss
November 21, 2004:
Curcumin),
which has demonstrated anti-cancer properties in laboratory and animal studies
of lung, colon and breast cancer conducted by Bharat
Aggarwal, M.D., a professor
in the department of Bioimmunotherapy Research
April
22, 2004:
Curry ingredient tested in cystic fibrosis fight...Daily Curcumin
slashed the death rates of CF-stricken mice.
April 19, 2004:
Spice Protects Brain
Cells, Could Prevent Alzheimer's Disease...Curcumin -- also known as cumin or
curry -- is a natural spice that has high levels of phenols, potent antioxidants
that can prevent cell damage caused by free radicals.
April 04, 2004:
Curry spice could alleviate cystic fibrosis...Curcumin, a
component of turmeric, makes it possible for the protein to escape to the cell
surface by starving the inspector proteins of calcium.
December
1, 2003 (Healthcentral.com)
- "Turmeric Eases Suffering From Psoriasis...
researchers are looking into the potential health benefits of
Curcumin,
a key component of turmeric. One group found that
Curcumin
inhibits an enzyme called PhK associated with overactive cell growth in
psoriasis"
September
13, 2003
(Spizes.com)
- "This
research proves that
Curcumin may prove to
be a cheap, well-tolerated, and effective therapy for inflammatory bowel
disease. This food ingredient has for generations been regarded as a potent
anti-inflammatory within many eastern civilizations. It is equally
intriguing that the same agent is a potent
antineoplastic agent."
September
9, 2003
(Healthcentral.com) - "Eating Turmeric on Cereal Helped Psoriasis
Sufferer...
Curcumin,
the active ingredient, has anti-oxidant
and anti-inflammatory properties. Researchers are studying this compound
in conditions as diverse as Alzheimer's
disease, arthritis and certain cancers."
August
26, 3003
(Yahoo!
News) - "Dietary constituents like
Curcumin,
a component of the spice turmeric (Curcuma longa); might have anti-inflammatory
properties that can effectively treat delibitating illnesses like Crohn's
disease (inflammatory bowel illness) or ulcerative colitis."
June
8, 2003 (Charlotte Observer) -
"Q.
Could you please respond to all of the articles that I've been reading lately
that hail turmeric as a powerful herb for its anti-inflammatory abilities,
cancer-prevention abilities and much more?
A. Turmeric has been used as a spice in Indian cooking for centuries. It adds
the yellow color and distinctive flavor to curry.
Researchers have been studying an ingredient in turmeric called anti-inflammatory abilities,
cancer-prevention abilities and much more?
A. Turmeric has been used as a spice in Indian cooking for centuries. It adds
the yellow color and distinctive flavor to curry.
Researchers have been studying an ingredient in turmeric called
Curcumin. This
compound has antioxidant
activity and also has strong anti-inflammatory properties."
June
7, 2003
(New Zealand Health) -
" This herb contains the yellow pigment curcumin.
Curcumin tends to stay in the gastrointestinal tract, where it seems to block the release of cell-damaging
substances. It is
linked
to possible prevention
of colon cancer, and in laboratory studies has been shown to slow the spread of
prostate cancer cells."
March
27, 2003
(Spizes.com)
- "Curcumin
could stop cancer cells with multiple myeloma from
replicating and kill off the remaining cancerous cells."
March
20, 2003 (Yahoo
News)
- "Curcumin,
the substance that gives the spice turmeric its distinctive yellow colour, stopped
the changes caused by excessive alcohol consumption that lead to liver damage.
The research adds to the repertoire of benefits already shown by
Curcumin,
which include anti-oxidant
properties and anti-cancer activity."
March
13, 2003 (Reuters Health) - An ingredient in the
curry spice
turmeric may help suppress and destroy a
blood cancer, early lab research shows--suggesting yet another health benefit
from this long-heralded substance. Studies
have also shown that
Curcumin, even in large quantities, does
not produce any known side effects in humans, the researcher noted. Based
on this evidence, Aggarwal recommended that
people
with cancer should try to eat more Curcumin, if possible. "Whichever way
you can take it, as much as possible,"
February
2003
Curcumin
(diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells
February
12, 2003 (American Physiological Society) - Curcumin,
the substance that gives turmeric its yellow color, and found in curry, has been
found to consist of a natural anti-inflammatory compound. Scientists have
already shown that it can suppress
tumor blood vessel growth ...Curcumin
inhibits alcohol-induced liver injury and lipid peroxidation
inhibits alcohol-induced liver injury and lipid peroxidation...Not
only did curcumin prevent alcohol-induced necroinflammatory changes, the yellow
pigment from roots and pods of Curcuma longa stopped
lipid peroxidation and the expression of the NF-KB-dependent genes.
January
15, 2003 - "Now the humble Indian spice is being
tested in differing fashions in two national laboratories — with stunning
results — against cancer... Curcumin is a substance in curry long
believed to have health benefits.The Ohio State University of Columbus has also
posted exciting reports that turmeric has ‘‘demonstrated
anti-cancer effects at all stages of tumor development in rodents and showed
potential to kill cancer cells and prevent normal cells from being
cancerous."
November
20, 2002 (USA Today Weekend) - "Curcumin helps stifle
cancer. In test tubes, 80% of
malignant prostate cells self-destructed when exposed to
Curcumin.
Feeding mice
Curcumin
dramatically slowed the growth of implanted human
prostate cancer cells. It may do the same in breast and colon cancer cells,
researchers say, speculating that
Curcumin
blocks the activation of genes
that trigger cancer. Bonus:
Curcumin's
anti-inflammatory activity
reduces
arthritic swelling
and progressive brain damage in animals. In UCLA research,
eating food laced with low doses of
Curcumin slashed Alzheimer's-like
plaque"
October
8, 2002 (Reuters Health) - "A compound found in the curry spice
turmeric may suppress production of a protein that spurs tumor
growth in
the body, researchers report...If the spice component does indeed
reduce IL-8 activities as the findings suggest, "Curcumin is capable of
working as a potent agent that reduces tumor promotion," the researchers
conclude. The study, in a recent issue of the journal Cancer, is not the first
to link
Curcumin, a compound thought to be a potent anti-inflammatory
agent, with certain health benefits.
Curcumin, a compound thought to be a potent anti-inflammatory
agent, with certain health benefits. Curcumin, a compound thought to be a potent anti-inflammatory
agent, with certain health benefits. Studies also suggest that the compound
might help heal wounds and fight Alzheimer's disease and multiple
sclerosis."
October
7, 2002 (University of Rochester
Medical Center) - "Cancer researchers at the University of Rochester
Medical Center have found that
Curcumin, a substance in curry long
believed to have health benefits, seems to protect skin during radiation
therapy.
Curcumin, the substance that gives turmeric its yellow color, is
a natural anti-inflammatory compound and
scientists have already shown that it
can suppress tumor blood vessel growth. This process, called
anti-angiogenesis,
can strangle tumors."
June 12, 2002
(Dr. Weil) - "Curcumin
blocked the accumulation of
beta-amaloid plaque and also appeared to reduce inflammation related to Alzheimer’s disease in neurologic
tissue.
....Researchers at the University of Illinois have also found that it helps prevent plaque formation. And preliminary studies at Vanderbilt University suggest that
Curcumin
may block the progression of multiple sclerosis...Curcumin
reduced plaque in the Alzheimer’s disease
...Turmeric appears to have significant
Anti-inflammatory and cancer-protective effects as well"
May
22, 2002 (Reuters Health) - "The curry spice Turmeric may help reduce and even prevent inflammation of the
intestines...The spice contains
Curcumin, a compound thought to be a potent
anti-inflammatory agent"
May
15, 2002 (Spizes.com) - "Turmeric can reduce
radiotherapy-induced side-effects and radition burns"
April 24, 2002
(Reuters Health)
-
"Interest in the potential neuroprotective properties of
Curcumin
rose after studies found
very low levels of neurological diseases such as Alzheimer's
in elderly Indian populations. Added to this were studies confirming
Curcumin
as a
potent anti-inflammatory agent,
effective in wound healing"
April
5, 2002
(Reuters Health) - "The substance that gives the spice
Turmeric its yellow color may help fight cancer, preliminary
evidence suggests. Researchers have found that the active ingredient in
Turmeric called
Curcumin,
can
enhance the cancer-fighting ability "
April
4, 2002
(Discovery Health Channel) -
"Preliminary studies in rats suggest that
Curcumin,
a compound found in the curry spice turmeric, may block the progression of
multiple sclerosis (MS)...Interest in the potential neuroprotective
properties of Curcumin rose after studies
found very low levels of neurological
diseases such as Alzheimer's in elderly Indian populations. Added to this
were studies confirming
Curcumin
as a potent anti-inflammatory agent, effective in wound healing. And just
last fall, researchers at the University of California, Los Angeles reported
that Curcumin appeared to slow
the progression of Alzheimer's in mice."
"Therapeutic
potential of
Curcumin in human prostate cancer. Curcumin
inhibits
proliferation, induces apoptosis, and
inhibits
angiogenesis of prostate cancer cells."
"Results:
Animals in which tumors had been initiated with DMBA and promoted with TPA experienced
significantly fewer tumors and less tumor volume
if they ingested either 0.2% or 1%
Curcumin diets."
"Results
from a small 3-year study in patients with uveitis suggest that
Curcumin
(375 mg taken orally three times daily) worked as well as corticosteroid
medications but without the side effects. In addition, the
rates of recurrence as well as complications from uveitis were similar to the
rates of patients taking corticosteroid medications. No patients complained of
side effects from the Curcumin"
"Diets
rich in Curcumin,
a compound found in the curry spice Turmeric, may help explain why rates
of Alzheimer's disease are much lower among
the elderly in India compared with their Western peers."
"Curcumin
acts as an anti-angiogenic
agent, meaning it stops
or prevents the production of blood vessels that feed tumors"
"Numerous
studies have found that Curcumin
suppresses
the proliferation of cancer cells and cholesterol/heart disease."
"It
has been known for thousands of years in Ayurvedic medicine that Turmeric extracts were
beneficial
for inflammatory conditions such as arthritis --
[and] since the '60s, there have been hundreds
of publications on the mechanisms of Anti-inflammatory effects of
Curcumin
...Curcumin
has the additional benefit of reducing
oxidative damage of the brain, which is several-fold elevated in Alzheimer's disease
and likely contributes greatly to memory loss," says Frautschy.
"Turmeric's
protective effects on the cardiovascular
system include lowering
cholesterol and triglyceride levels,
decreasing susceptibility of low density lipoprotein (LDL) to lipid peroxidation,
(32) and inhibiting
platelet aggregation.
(33)"
"Turmeric
reduced
the number of these plaques by a half. The
researchers also found that Turmeric had other health benefits. It aids
digestion, helps fight infection and
guards
against heart attacks."
"Curcumin
has been shown to exert even more impressive effects than aspirin in
inhibiting colon cancer. In addition
to inhibiting prostaglandin formation, Curcumin also exhibits potent
antioxidant effects (in some experimental studies it was up to 300
times more potent than vitamin E)."
"Curcumin
could be a potentially therapeutic anti-cancer
agent, as it significantly inhibits prostate cancer growth, as
exemplified by LNCaP in vivo, and has the potential to prevent
the progression of this cancer to its hormone refractory
state"
Curcumin,
a compound found in turmeric (Curcuma longa), has a number of potential
cancer-preventing
mechanisms
of action. The first is its inhibitory effect on the proinflammatory enzymes
cyclooxygenase and lipoxygenase. A study found the anti-inflammatory
efficacy of curcumin to be superior to indomethacin.
Curcumin
has also
been found to induce G2/M phase
cell cycle arrest in human colon cancer cells
independently of its control of prostaglandin synthesis...Curcumin's
tumor inhibiting effect is similar to many of the NSAIDs, including aspirin,
ibuprofen, and indomethacin. A diet containing two-percent curcumin by weight reduced
the percentage of animals developing colon cancers from 40 percent to
zero."
"Curcumin,
a major yellow pigment and active component of turmeric, has been shown
to possess anti-inflammatory and anti-cancer
activities. Cyclooxygenase (COX)-2 plays an important role in
colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression,
we treated HT-29 human colon cancer
cells with various concentrations of
Curcumin. Curcumin
inhibited the cell growth of HT-29 cells in a concentration-
and time-dependent manner. Curcumin
markedly inhibited the mRNA and
protein expression of COX-2, but not COX-1. These data suggest that a non-toxic
concentration of Curcumin
has a significant effect on the in vitro growth of HT-29 cells, specifically
inhibits COX-2 expression, and may have value as a safe
chemopreventive agent for colon cancer."
"The
effects of 500 mg of Curcumin
administered orally via capsules on serum
peroxides and cholesterol levels were compared in 10 human volunteers before and
after administration for 7 days. No
adverse effects were
reported. The data indicated significant decreases
in serum lipid peroxides and in total cholesterol, (and) a significant increase
in HDL(good) -cholesterol"
"The
Anti-carcinogenic effects of Turmeric and Curcumin
are due in part to
direct antioxidant and free-radical
scavenging effect; but, they also enhance
the body's natural antioxidant system,
increasing glutathione levels, thereby aiding in hepatic detoxification
of mutagens and carcinogens, and inhibiting nitrosamine formation."
"Curcumin,
a spice widely used in Indian dishes, has anti-carcinogenic
and anti-inflammatory properties.
It also inhibits the oestrogenic effects of DDT and is synergistic with
phytooestrogens.A dietary modification with the introduction of soy products,
Curcumin,
cruciferous vegetables and low fat could be beneficial in reducing
the risk of developing cancer and
possibly the effects of DDT."
"Curcumin...can
retard the progress of dementia, according to a study
conducted by an American expert...
Curcumin
is found to be far more effective, Prof Jeffrey Cummings of the
University of California in Los Angeles (ULCA), who conducted the study, said."
"Turmeric
extracts were responsible for
dramatic
improvements in some patients with oral cancer
and significantly reduced urinary
excretion of tobacco mutagens in smokers. Also, the American Health
Foundation, a prestigous mainstream biomedical research center in Valhalla,
N.Y., has demonstrated inhibition
of colon cancer and regression of colon tumors with
Turmeric extracts."
"Curcumin,
a natural polyphenol and potent
antioxidant, has shown chemopreventive
activity in
preclinical models. It has also been associated with regression
of established malignancy"
"Research
suggests that
Curcumin,
the bright yellow flavonoid present in turmeric (Curcuma longa) roots,
selectively inhibits... the blood to clot, [and] prevents
excessive inflammatory response and reduces damage to vascular
endothelia. Curcumin
has also been shown to inhibit tobacco
smoke mutagenicity, suggesting it may help Curcumin,
the bright yellow flavonoid present in turmeric (Curcuma longa) roots,
selectively inhibits... the blood to clot, [and] prevents
excessive inflammatory response and reduces damage to vascular
endothelia. Curcumin
has also been shown to inhibit tobacco
smoke mutagenicity, suggesting it may help protect
the vascular endothelia from damage caused by smoking"
"also
aids
digestion, particularly of protein, promotes absorption and regulates
metabolism."
"Curcumin
is a powerful
antioxidant and anti-inflammatory compoundfound
in the curry spice Turmeric, which has a long history of dietary and medicinal
use"
Curcumin 'may slow Alzheimer's'
|
ALBERT EINSTEIN COLLEGE OF MEDICINE
DEPARTMENT OF PATHOLOGY
Brosnan CF. 2001
Curcumin has been used for centuries to treat inflammatory disorders. Due to its
low toxicity it is currently under consideration as a broad anti- inflammatory,
anti- tumor cell agent. We conclude that gammadelta T cells (allergic
inflammatory agents)...are highly sensitive to curcumin and that this effect may
contribute to the anti- inflammatory properties of this compound. PMID*: 11544338,
8 Researches
HOSPITAL OF THE NORTH SHORE- LONG ISLAND JEWISH
HEALTH SYSTEM Trachtman H. 2003
The protective effect of curcumin against (toxin)- induced injury…was not
related to its antioxidant properties. Instead, curcumin enhanced expression of
heat shock protein… PMID: 11322764- 3 Researchers
DEPARTMENT OF ONCOLOGY, Augenlicht LH. 2003
The butyrate response was compared in detail with…curcumin, a component of
mustard and curry structurally and functionally related to sulindac that also
has chemopreventive activitiy. PMID: 10969808- 3 Researchers
AMERICAN HEALTH FOUNDATION
CHEMOPREVENTION PROGRAM
Reddy BS. 1999
Curcumin inhibited colonic (tumor) formation (in an animal modeo) by 45%. PMID:
10223193- 4 Researchers
AMERICAN HEALTH FOUNDATION
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS. 1999
Thus, chemopreventive activity of curcumin is observed when it is administered
prior to, during, and after carcinogen treatment as well as when it is given
only during the promotion/progression phase (starting late in premalignant
stage) of colon carcinogenesis. PMID: 9973206- 7 Researchers
AMERICAN HEALTH FOUNDATION
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS. 1995
The results indicate that dietary administration of curcumin significantly
inhibited incidence of colon adenocarcinomas and the multiplicity of invasive,
noninvasive, and total (invasive plus noninvasive) adenocarcinomas. Dietary
curcumin also significantly suppressed the colon tumor volume by >57%
compared to the control diet. Although the precise mechanism by which curcumin
inhibits colon tumorigenesis remains to be elucidated, it is likely that the
chmopreventive action, at leasat in part, may be related to the modulation of
arachidonic acid metabolism (the pathway that also leads to inflammatory COX-
2). PMID: 7812955- 5 Researchers
AMERICAN HEALTH FOUNDATION
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS. 1993
The results of the present study indicate that curcumin, present in turmeric,
inhibits AOM- induced colonic preneoplastic lesions and other cellular events
relevant to colon carcinogenesis. PMID: 8242846- 3 Researchers
BAYLOR COLLEGE OF MEDICINE
THE DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
Tan TH. 1998
Curcumin, a dietary pigment in curry, suppresses tumor initiation and tumor
promotion.... Taken together, the inhibition of the MEKK1- JNK pathway reveals a
possible mechanism of suppression of AP- 1 and NF- kappaB signaling (proteins
overexpressed in pathological inflammation and cancer states) by curcumin, and
may explain the potent anti- inflammatory and anti- carcinogenic effects of this
chemical. PMID: 9674701- 2 Researchers
CANCER RESEARCH CENTER OF HAWAII
ETIOLOGY PROGRAM
Cooney RV. 1999
Heterocyclic aromatic amines (HAAs), a group of chemicals formed during high-
temperature cooking of meat and fish, are potent mutagens and are suspected to
play a role in colorectal (and just about every other form of) cancer.Lower
levels of PhIP and MeIQx were observed in meat marinated with turmeric- garlic
sauce. In contrast, marinating with barbecue sauce caused a 2.9- and 1.9- fold
increase in PhIP and a 4- and 2.9- fold increase in MeIQx PMID: 10578481- 3 Researchers
COLUMBIA UNIVERSITY
COLLEGE OF PHYSICIANS AND SURGEONS
Katz AE. 2001
Curcumin causes a marked decrease in the extent of cell proliferation…and…could
be a potentially therapeutic anti- cancer agent, as it significantly inhibits
prostate cancer growth,…and has the potential to prevent the progression of
prostate cancer to its hormone refractory state.
PMID: 11398177- 5 Researchers
COLUMBIA UNIVERSITY
COLLEGE OF PHYSICIANS AND SURGEONS
Katz AE. 2000
These results, taken together with our previous results that curcumin can induce
apoptosis in both androgen- dependent and androgen- independent prostate cancer
cells, support our view that curcumin may be a novel modality by which one can
interfere with the signal transduction pathways of the prostate cancer cell and
prevent it from progressing to its hormone- refractory state.
PMID: 10851300 - 3 Researchers
CORNELL UNIVERSITY
THE NEW YORK HOSPITAL-
CORNELL MEDICAL CENTER
Bertagnolli MM. 2000
These data (approximately 63% decreased adenoma tumor formation) place the plant
phenolics CAPE and curcumin among a growing list of anti- inflammatory agents
that suppress Apc- associated intestinal carcinogenesis. PMID: 10783313- 8 Researchers
CORNELL UNIVERSITY
DR. MITCHELL GAYNORE, MEDICAL DIRECTOR. 2001
Although there is abundant science to support the potential of nutritional
therapies such as the natural COX- 2 inhibitors found in red wine and turmeric
and the phytoestrogens, in soy for cancer prevention, few doctors are aware of
this information. DEPARTMENT OF SURGERY, Bertagnolli MM. 2000
These results show that mucosal…T cells and B cells increase in animals
treated with curcumin, suggesting that curcumin modulates lymphocyte- mediated
immune functions. PMID: 10729246- 4 Researchers
CORNELL UNIVERSITY
DEPARTMENT OF CARDIOTHORACIC SURGERY
Dannenberg
AJ. 1999 We found that curcumin directly inhibited the activity of COX- 2. These data
provide new insights into the anticancer properties of curcumin. PMID: 10190560-
5 Researchers
CORNELL UNIVERSITY
DEPARTMENT OF MEDICINE
Rigas B. 1997
Curcumin, the active ingredient of the rhizome of the plant turmeric (Curcuma
longa Linn), a commonly used spice, prevents cancer in animal tumor models. The
role of curcumin’s antiproliferative effect in human colon cancer remains to
be established. PMID: 9422331- 4 Researchers
CORNELL UNIVERSITY
CORNELL CANCER RESEARCH LABORATORY
Nitin T. Telang, 1994
Curcumin, despite being an antioxidant, is also a non- steroidal anti-
inflammatory agent. It is probable that curcumin may selectively kill clones of
tumor cells, as has been reported. 1 Researcher
CORNELL UNIVERSITY
DEPARTMENT OF INTERNAL MEDICINE
Awasthi YC. 1999
Curcumin, an antioxidant present in the spice turmeric (Curcuma longa), has been
shown to inhibit chemical carcinogenesis in animal models and has been shown to
be an anti- inflammatory agent… These results suggest that GSTs play a major
role in detoxification of lipid peroxidation products…and that these enzymes
are modulated by curcumin. PMID: 10514034- 7 Researchers
EMORY UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PHARMACOLOGY
Pavlath GK. 1999
Skeletal muscle is often the site of tissue injury due to trauma, disease,
developmental defects or surgery. Yet, to date, no effective treatment is
available to stimulate the repair of skeletal muscle…Systemic administration
of the NF- kB inhibitor curcumin stimulates muscle regneration after traumatic
injury. The striking effects of curcumin on myogenesis suggest therapeutic
applications for treating muscle injuries. PMID: 10444409- 5 Researchers
EMORY UNIVERSITY SCHOOL OF MEDICINE
DIVISION OF CARDIOLOGY
Medford RM. 1998
(Curcumin was also found to inhibit TNF activated VCAM- 1, a pathway which can
lead to pathological inflammation and is implicated in atherosclerosis). PMID:
9468519- 3 Researchers
FLORIDA A&M UNIVERSITY
COLLEGE OF PHARMACY AND PHARMACEUTICAL SCIENCES
Mazzio EA. 1998
Excessive nitric oxide (NO) production in the brain has been correlated with
neurotoxicity and the pathogenesis of several neurodegenerative diseases.
(Curcumin and other plant compounds were shown to significantly inhibit this
potentially problematic imbalance). PMID: 9714085- 2 Researchers
UCLA MEDICAL CENTER
Shoskes DA. 2000
The combination of mycophenolic acid with curcumin…reduces rental injury and
facilitates repair. PMID: 10688038- 2 Researchers
UCLA MEDICAL CENTER
DEPARTMENT OF SURGERY, UCLA SCHOOL OF MEDICINE
Shoskes DA. 1998
curcumin reduce ischemia- reperfusion (blood flow obstructed)
injury and its inflammatory sequelae. The bioflavonoids (curcumin) holds promise
as agents that can reduce immune and nonimmune renal injury, the key risk
factors in chronic graft loss. PMID: 9701255- 1 Researcher
HARVARD MEDICAL SCHOOL
Freeman MR. 1999
[This group is looking at the relationship between curcumin, AP- 1 (a key player
in the inflammatory cascade) and bladder muscle health]. PMID: 10444406- 7 Researchers
HARVARD MEDICAL SCHOOL
DEPARTMENT OF DERMATOLOGY
Byers HR 1998
These results indicate that curcumin has direct antiangiogenic activity in vitro
and in vivo. The activity of curcumin in inhibiting carcinogenesis in diverse
organs such as the skin and colon may be mediated in part through angiogenesis
inhibition. PMID: 10780880- 8 Researchers
HENRY FORD HOSPITAL
DEPARTMENT OF MEDICINE
Chapman RA. 1998
We have investigated the antiproliferative effect of curcumin, an antitumor
agent with antioxidant and anti- inflammatory properties...These findings have
implications for developing curcumin- based anticancer and anti- inflammation
therapies. PMID: 9719490- 5 Researchers
HENRY FORD HOSPITAL
DIVISION OF HEMATOLOGY/ONCOLOGY
Gautam SC. 1997-
98 (Curcumin was also found to inhibit aspects of the NF- Kappa B cascade, a
pathway which can lead to pathological inflammation and cancer proliferation).
PMID: 9439980- 5 Researchers.
HENRY FORD HOSPITAL
DEPARTMENT OF INTERNAL MEDICINE
Gautam SC. 1997-
98 (This group of scientists from Henry Ford Hospital are investigating curcumins
role as an anti- inflammatory in this most complex biochemical pathway). PMID:
9168063- 6 Researchers
MANHATTAN EYE, EAR AND THROAT HOSPITAL
DEPARTMENT OF OTOLARYNGOLOGY
Schantz SP. 1998
(Curcumin and other agents were found to inhibit two cell lines of head and neck
squamous cell carcinomas). PMID: 9482545- 5 Researchers
MEDICAL COLLEGE OF OHIO
DEPARTMENTS OF UROLOGY AND PATHOLOGY
Selman SH. 2002
The development of an effective nontoxic agent that may be used immediately
after bladder tumor resection to prevent the implantation of tumor cells would
be a significant clinical advancement…curcumin is a potent cytotoxic agent
against (multiple) bladder tumor cell lines. Curcumin effectively inhibits tumor
implantation and growth in this murine bladder tumor model. PMID: 11547120- 5
Researchers
MEMORIAL SLOAN- KETTERING CANCER CENTER
DEPARTMENT OF SURGERY, HEAD AND NECK SURGERY
Sacks PG. 1998
Combinations allowed for a dose reduction of 4.4- 8.5- fold for EGCG and 2.2-
2.8- fold for curcumim. EGCG and curcumin were noted to inhibit neoplastic
growth by different mechanisms, a factor which may account for their
demonstrable interactive synergistic effect. PMID: 9525275 – 5 Researchers
MEMORIAL SLOAN- KETTERING CANCER CENTER
SCHANTZ S. 1997
Effective chemoprevention of aerodigestive tumors could have far- reaching
effects. Aerodigestive cancer accounts for one- third of all cancer deaths in
the United States and is the most common cancer in some areas of the
world...Novel agents are under development (especially for heavy smokers):
epigallacatchin gallate, or green tea, curcumin, and a new emphasis on folic
acid. PMID: 9433643- 2 Researchers
MERCY CANCER INSTITUTE
CANCER RESEARCH LIBRARY
Zaren HA 1998
Results of the present study suggest that curcumin may inhibit BaP- induced
forestomach cancer in mice by affecting both activation as well as inactivation
pathways of BaP metabolism in the liver...Therefore, it seems reasonable to
postulate that curcumin may exert anticarcinogenic activity either by inhibiting
activation of BaP or (and) by enhancing the detoxification of (+)- anti- BaPDE
(the metabolite of BaP that is highly carcinogenic). PMID: 9744529- 7 Researchers
MICHIGAN STATE UNIVERSITY
DEPARTMENT OF HORTICULTURE AND NATIONAL SAFETY
AND TOXICOLOGY CENTER
Nair MG. 2000
(Curcuminoids) from Cucuma longa were assayed for their cytotoxicity,
antioxidant and anti- inflammatory activities. These compounds showed activity
against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines.
Curcumins I- III also showed good inhibition of the COX- II enzyme…PMID:
10969724- 3 Researchers
MICHIGAN STATE UNIVERSITY
DEPARTMENT OF HORTICULTURE AND NATIONAL SAFETY
AND TOXICOLOGY CENTER
Nair MG. 1998
…three curcuminoids displayed topoisomerase I and II enzyme inhibition
activity (an imbalance or excess in topoisomerase enzyme activity, the enzyme
responsible for breaking and repairing DNA, is believed at the root of many
cancer processes). PMID: 9584408- 3 Researchers
NATIONAL CANCER INSTITUTE
DIVISION OF CANCER PREVENTION
Sigman CC. 2000
Numerous diet- derived agents are included among the >40 promising agents and
agent combinations that are being evaluated clinically as chemopreventive agents
for major cancer targets including breast, prostate, colon and lung. Examples
include green and black tea…curcumin…PMID: 10721931- 13 Researchers
NATIONAL CANCER INSTITUTE
LABORATORY OF CELLULAR AND MOLECULAR
BIOLOGY
Boone CW. 1998
(Researchers concluded curcumin and green/black tea extracts prevented radiation
induced DNA damage). PMID: 9858893- 7 Researchers
NATIONAL CANCER INSTITUTE
DIVISION OF BASIC SCIENCES
Pommier Y. 1997
(The NCI has been investigating curcumin for specific activities against HIV).
PMID: 9301668- 7 Researchers
NATIONAL CANCER INSTITUTE
DIVISION OF CANCER PREVENTION AND CONTROL (DCPC),
Sigman CC. 1996
(Curcumin is one of a number of plant compounds that are under investigation by
the Division of Cancer Prevention and Control (DCPC) of the National Cancer
Institute as a “promising chemopreventive agent.” PMID: 9154168- 25
Researchers
NATIONAL CANCER INSTITUTE
LABORATORY OF MOLECULAR
PHARMACOLOGY
Pommier Y.
1995 The present data suggest that HIV- 1 integrase inhibition may contribute to the
antiviral activity of curcumin. These observations suggest new strategies for
antiviral drug development that could be based upon curcumin as a lead compound
for the development of inhibitors of HIV- 1 integrase. PMID: 7748198- 5 Researchers
NATIONAL CANCER INSTITUTE
CELLULAR DEFENSE AND CARCINOGENESIS
SECTION
Yeh GC 1998
These results suggest that the chemopreventive effect of curcumin may be due, in
part, to its ability to compete with aryl hydrocarbons for both the AhR and
CYP1A1 (part of an essential detoxification enzyme system).... The
chemopreventive effect of curcumin has been variously ascribed to the
antioxidant properties of curcumin, inhibition of cyclooxygenase activity,
suppression of activator protein- 1- mediated transcription, and induction of
apoptosis of tumor cells. Based on our results, curcumin also appears to
decrease carcinogen activation. PMID: 9698073- 4 Researchers
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND
STROKE
EXPERIMENTAL THERAPEUTIC BRANCH
George S. Roth. 1999
Thus, our results suggest that DA triggers a death program via oxidative stress-
mediated activation of nuclear transcription factors AP- 1 and NF- kB. These
apoptotic molecular events may explain the DA- related neurodegenerative
processes. 5 Researchers
NATIONAL INSTITUTE ON AGING
MOLECULAR PHYSIOLOGY AND GENETICS SECTION,
GERONTOLOGY RESEARCH CENTER
Roth GS. 1999
(Utilizing curcumin studying inflammation factors AP- 1 and NF- kappa B to help
determine the mechanisms at play in normal cell metabolism). PMID: 10419543- 5 Researchers
NEW YORK MEDICAL COLLEGE
GRADUATE SCHOOL OF HEALTH SCIENCES
Duvvi, 2001.
Curcumin, a spice widely used in Indian dishes, has anti- carcinogenic and anti-
inflammatory properties. It also inhibits the oestrogenic effects of DDT and is
synergistic with phytoestrogens. PMID: 11467202- 1 Researcher
NORTH CAROLINA STATE UNIVERSITY
AGRICULTURAL RESEARCH SERVICE, U.S. DEPARTMENT OF AGRICULTURE, AND NORTH
CAROLINA AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF FOOD SCIENCE
Fleming HP. 2003
Turmeric was found to almost completely prevent aldehyde formation. PMID:
11052754- 3 Researchers
NORTHWESTERN UNIVERSITY
DEPARTMENT OF PATHOLOGY
M. S.V. Bhide. 1992
This study shows that curcumins inhibit cancer at initiation, promotion and
progression stages of development...The results of our anticarcinogenicity
studies with curcumins are strengthened by the recent epidemiological finding
that dietary intake of turmeric may provide protection against pulmonary cancer
among cigarette smokers...Curcumins inhibit the initiation step of
carcinogenesis by changing the activity of phase I and phase II carcinogen
metabolizing enzymes, thus altering the nature and lowering or removing potent
proximate carcinogens that can reach critical intracellular targets. 2 Researchers
PENNSYLVANIA STATE UNIVERSITY COLLEGE OF MEDICINE
DEPARTMENT OF MEDICINE
Kumar R. 1995
These findings demonstrate that curcumin is a potent inhibitor of a growth
stimulatory pathway,…and may potentially be useful in developing anti-
proliferative strategies to control tumor cell growth. PMID: 7634398- 4
Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY
Conney AH. 1997
(Curcumin was observed to have a strong inhibitory effect on multiple models of
tumor formation in animals). PMID: 9054592- 8 Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY
Conney AH. 1997
Combinations of curcumin and RA (vitamin like compound) have a particularly
potent inhibitory effect on the proliferation of HL- 60(human leukemia ) calls.
PMID: 9112257- 5 Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY
Frenkel K. 1997
(Topical curcumin demonstrated significant antitumor effects against mutiple
animal models. Significant activities wer eobserved with all curcuminoids).
PMID: 9591190- 3 Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1995
(Rutger’s researchers investigated different curcuminoids for their anti-
tumor effects and found that I and II were most active). PMID: 7586157- 8
Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF BIOLOGICAL SCIENCES
Huang HI. 1995
(In chronic inflammation, signals induce the production of nitric oxide (NO.)
that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite.
Curcumin and compounds from rosemary and tea inhibit this compound). PMID:
7553604- 3 Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF BIOLOGICAL SCIENCES
Chan MM. 1995
Curcumin, contained in the rhizome of the plant Curcuma longa Linn, is a
naturally occurring phytochemical that has been used widely in India and
Indonesia for the treatment of inflammation. ...(Curcumin was also found to
inhibit activation of NF- Kappa B, a pathway which can lead to pathological
inflammation and cancer proliferation). There was more than a thousand-
fold difference between the efficacy of curcumin (5uM) and that of NAC (60mM).
PMID: 7786295- 1 Researcher
RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1994
These results indicated that not only did curcumin inhibit the number of tumors
(colon, forestomach and duodenum) per mouse and the percentage of mice with
tumors but it also reduced tumor size. PMID: 7954412- 6 Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1992
(Topical application of benzo(A)pyrene (B(a)P), a most potentially carcinogenic
compound in smoke, was significantly inhibited by application of curcumin).
PMID: 1423891- 5 Researchers
RUTGERS UNIVERSITY
DEPARTMENT OF CHEMICAL BIOLOGY AND PHARMACOGNOSY
Conney AH. 1992
This result suggests that dietary curcumin may inhibit AOM (powerful carcinogen)-
induced colonic neoplasia in mice. PMID: 1611594- 6 Researchers
STANFORD UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENTS OF SURGERY AND GENETICS
Michael R. Freeman
Previous studies have demonstrated that curcumin (diferuloylmethane), a potent
inhibitor of tumor promotion, inhibits AP- 1- mediated transcription. 7 Researchers
TUFTS UNIVERSITY SCHOOL OF MEDICINE
Fini ME. 2002
Our findings provide evidence that curcuminoids target the FGF- 2 angiogenic
signaling pathway [FGF- 2 stimulates the growth and development of new blood
vessels (angiogenesis) that contribute to the pathogenesis of several diseases
(i.e. cancer, atherosclerosis)] and inhibit expression of gelatinase B [an
essential component in the process of tumour invations and metastasis]in the
angiogenic process. PMID: 10744729- 8 Researchers
TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENTS OF OPHTHALMOLOGY AND ANATOMY AND
CELLULAR BIOLOGY
M. Elizabeth Fini. 1999
Curcuminoids, natural products of the Indian spice turmeric, are potent
antioxidant and anti- inflammatory agents that have been entered into Phase I
clinical trials for chemo- preventation by the National Cancer Institute. At
least part of their biological activity can be attributed to their capacity to
inhibit activation of AP- 1 and NF- kB transcription factors...To our knowledge,
this is the first study showing the efficacy of curcuminoids as implantable
drugs for inhibition of angiogenesis locally or as orally active drugs to
inhibit angiogenesis systemically...Our findings provide evidence that
curcuminoids target the FGF- 2 angiogenic signaling pathway and inhibit
expression of gelatinase B in the angiogenic process. 8 Researchers
TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF FAMILY MEDICINE AND COMMUNITY HEALTH
Line PS. 1998
These data suggest that combinations of natural plant compounds (curcumin and
isoflavones) may have preventive and therapeutic applications against the growth
of breast tumors induced by environmental estrogens. PMID: 9831541- 3 Researchers
TUFTS UNIVERSITY SCHOOL OF MEDICINE
DIVISION OF NUTRITIONAL CARCINOGENESIS
Reddy BS.
1997 (Curcumin and other agents may plan an important inhibitory role in the
promotion/progression stage of colon carcinogenesis). PMID: 9102217- 5 Researchers
TUFTS UNIVERSITY SCHOOL OF MEDICINE
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH
SCIENCES
Maheshwari RK. 1999
These results show that curcumin enhanced would repair in diabetic impaired
healing, and could be developed as a pharmacological agent in such clinical
settings. PMID: 10564565- 8 Researchers
TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PATHOLOGY, BETHESDA Maheshwari RK. 1998
It may be possible that transforming growth factor- beta1 plays an important
role in the enhancement of wound healing by curcumin. PMID: 9776860- 7 Researchers
TUFTS UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PATHOLOGY
Maheshwari RK. 1996
Since curcumin inhibited the proliferation of HUVEC (a model for testing
abnormal cell proliferation), it could turn out to be a very useful compound for
the development of novel anti- cancer therapy. PMID: 8913274- 4 Researchers
UNIVERSITY OF ARIZONA
COLLEGE OF PHARMACY
Schneider CD. 2000
(The University of Arizona has received a multi- million dollar U.S. government
grant to study turmeric’s anti- inflammatory activities. PMID: 10911509- 2
Researchers
UNIVERSITY OF CALIFORNIA
DEPARTMENTS OF MEDICINE AND NEUROLOGY
Cole GM 2001
Inflammation in Alzheimer’s disease (AD) patients is characterized by
increased cytokines and activated microglia... Low and high doses of curcumin
significantly lowered oxidized proteins and interleukin- 1beta, a
proinflammatory cytokine elevated in the brains of these mice. With low- dose
but not high- dose curcumin treatment, the astrocytic marker GFAP was reduced,
and insoluble beta- amyloid (Abeta), soluble Abeta, and plaque burden were
significantly decreased by 43- 50%. In view of its efficacy and apparent low
toxicity, this Indian spice component shows promise for the prevention of
Alzheimer’s disease. PMID: 11606625
UNIVERSITY OF CALIFORNIA SAN DIEGO
DIVISION OF GASTROENTEROLOGY, DEPARTMENT OF MEDICINE
Chauhan DP 2001
These data suggest that a non- toxic concentration of curcumin has a significant
effect on the in vitro growth of HT- 29 cells, specifically inhibits COX- 2
expression, and may have value as a safe chemopreventive agent for colon cancer.
PMID: 11566484- 3 Researchers
UNIVERSITY OF
CINCINNATI COLLEGE OF MEDICINE
CHILDREN’S HOSPITAL RESEARCH FOUNDATION
Stanberry LR. 1999
(Curcumin “provided significant protection” in an animal model against
herpes simplex virus type 2). PMID: 10443534- 4 Researchers
UNIVERSITY OF FLORIDA
ARGARWAL A. MEDICINE
Nick HS, 2001
HO- 1 occurs as an adaptive and protective response to several inflammatory
stimuli…Curcumin has anti- inflammatory antioxidant and renoprotective
effects. PMID: 11500326 – 4 Researchers
UNIVERSITY OF IDAHO
DEPARTMENT OF FOOD SCIENCE AND TOXICOLOGY
Hendrix K. 1997
(This group of scientists from the University of Idaho is studying curcumin’s
effects on animal immune functions.) PMID: 9049662- 3 Researchers
UNIVERSITY OF ILLINOIS
DEPARTMENT OF FOOD SCIENCE AND HUMAN NUTRITION
Fisher C. 1996
Therefore, curcumin when administered i.p. can act as an effective
chemopreventative agent towards DMBA- induced rat mammary tumorigenesis and
mammary adduct formation. PMID: 8635149- 4 Researchers
UNIVERSITY OF ILLINOIS AT CHICAGO
THE PROGRAM FOR COLLABORATIVE RESEARCH IN PHARMACEUTICAL
SCIENCE AND THE DEPARTMENT OF MEDICINAL CHEMISTRY AND PHARMACOGNOSY, COLLEGE OF
PHARMACY Kim JY 2001
…a novel curcuminoid isolate from turmeric that has been demonstrated to
protect neuronal cells from beta- amyloid insult… PMID: 11549465 – 2
Researchers
UNIVERSITY OF ILLINOIS AT CHICAGO
THE PROGRAM FOR COLLABORATIVE RESEARCH IN PHARMACEUTICAL
SCIENCE AND THE DEPARTMENT OF MEDICINAL CHEMISTRY AND PHARMACOGNOSY, COLLEGE OF
PHARMACY KIM JK 2001
beta- Amyloids (betaA) induced oxidative stress is a well- established pathway
of neauronal cell death in Alzheimer’s disease. From turmeric, Curcuma longa
L. (Zingiberaceae), three curcuminoids where found to protect cells from betaA
insult…These compounds were better antioxidants than alpha- tocopherol. alpha-
Tocopherol did not protect the cells from betaA insult…PMID: 11297823 – 3
Researchers PZZUTO JM. 1999 (Curcumin and other chemopreventives inhibit skin carcinogenesis
in an animal model) PMID: 10615860- 2 Researchers
UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
Chen
C. 1999 Curcumin is a potent inhibitor of Epstein- Barr virus cell lines. This effect
appears to be mediated through enhanced apoptosis. A further investigation of
this effect may be useful in prevention and therapy of B- cell lymphoma in
immunodeficient patients. PMID: 10527697- 6 Researchers
UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
BONDADA S. 1999
It has been well known that curcumin is a powerful inhibitor of proliferation of
several tumor cells.…NF- kappaB (critical factor in the pathology of
inflammation and cancer) binding activity was also downregulated almost
completely by curcumin…curcumin caused the growth arrest and apoptosis of
lymphoma (cell lines)…PMID: 10527691- 5 Researchers
UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
NAGABHUSHAN M. 1998
Curcumin (Cur) is a phenolic component of common spice, turmeric. We have
reported earlier that it possesses antineoplastic and immunosuppressive
properties in vitro. PMID: 9733605- 6 Researchers
UNIVERSITY OF KENTUCKY
DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, DEPARTMENT OF GENERAL SURGERY
NAGABHUSKAHN M. 1998
An extract of a common spice (turmeric) is an effective inhibitor of this (an
Epstein- Barr virus (EBV) related) process. PMID: 9457037- 5 Researchers
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
DEPARTMENT OF RADIATION ONCOLOGY
You W. 1999
Curcumin has anti- inflammatory, antiproliferative, and antitumor effects. The
results suggest that apoptosis (cellular suicide) is involved in the curcumin-
induced inhibition of tumor cell growth, and genes associated with cell
proliferation and apoptosis may be playing a role in the chemopreventive action
of curcumin.…[curcuma longa i.}…is getting the attention of cancer
investigators because of its chemopreventive properties against human
malignancies. PMID: 1044542- 2 Researchers
UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
DEPARTMENT OF SURGERY
Salahudeen AK. 1998
These findings provide evidence that turmeric and curcumin provide protection
against oxidative stress in a renal cell line. PMID: 9436613- 4 Researchers
UNIVERSITY OF MISSOURI- KANSAS CITY
HORMONE RESEARCH LABORATORY,
SCHOOL OF DENTISTRY AND MEDICINE
Virji AS. 2000
It is concluded that curcumin is considerably more potent than genistein and
quercetin, but cisplatin is five fold more potent than curcumin in inhibition of
growth and DNA synthesis…The data presented in this study demonstrate that
curcumin compares favorably with cisplatin in its inhibitory effect on both cell
growth and DNA synthesis in human oral squamous carcinoma cell line PMID:
10928101- 2 Researchers
UNIVERSITY OF NORTH CAROLINA
DEPARTMENT OF MEDICINE,
CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
Sarto RB. 1999
We conclude that curcumin potently inhibits cytokine- mediated NF- kappa B
activation (this group has identified a mechanism that this critical factor in
cancer and inflammation pathologies is inhibited). PMID: 10477620
UNIVERSITY OF NORTH CAROLINA
DEPARTMENT OF MEDICINE,
CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
R. BALFOUR SARTO, 1999.
Nontraditional or alternative medicine is becoming an increasingly attractive
approach for the treatment of various inflammatory disorders among patients
unresponsive to or unwilling to take standard medications....The use of natural
anti- inflammatory products provides an attractive and safe alternative to
modulate inflammatory disorders. Curcumin is an anti- inflammatory food product
that has been used for centuries in Asian cultures. However, the lack of
information regarding a mechanism of action for curcumin combined with unknown
effects on mucosal inflammatory gene expression have precluded the widespread
clinical use of curcumin in western cultures for treatment of intestinal
inflammatory disorders. Our data clearly indicate that cytokine- mediated
expression of the adhesion molecule ICAM- 1 and the chemokine IL- 8 in IEC’s
is blocked by curcumin treatment...Together, these data provide strong evidence
that curcumin blocks IEC gene expression by inhibiting the signal leading to IKK
activation, subsequent I- ?Bá phosphorylation/degradation, and NF- ?B
activation. This study provides a strong rational to investigate the effect of
curcumin in an in vivo experimental model of intestinal inflammation. 7
Researchers
UNIVERSITY OF PITTSBURGH
DEPARTMENT OF PATHOLOGY
Zarnegar R. 2002
(Confirmed that curcumin is an inhibitor of Ap- 1, a protein which can play a
pathophysiological role in the proliferation of cancer cells and inflammation).
PMID: 10713700- 3 Researchers
UNIVERSITY OF TEXAS
DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY
Ansari GA 2000
Curcumin (diferuloylmethane), a yellow pigment of turmeric with antioxidant
properties has been shown to be a cancer preventative in animal studies
conducting glutathione research. PMID: 10996298- 8 Researchers
UNIVERSITY OF TEXAS HEALTH CENTER AT TYLER
DEPARTMENT OF MOLECULAR BIOLOGY
Rao LV. 2000
We investigated the effect of curcumin, a natural plant phenolic compound known
to exhibit anticarcinogenic, antioxidant, and anti- inflammatory properties, on
Egr- 1 expression (regulates a number of pathophysiologically relevant genes)…the
data show that curcumin suppresses the induction of transcription factor Egr- 1.
PMID: 10674404- 2 Researchers
UNIVERSITY OF TEXAS HEALTH CENTER AT TYLER
DEPARTMENT OF MEDICAL SPECIALTIES
Rao LV. 2000
Overall, the data suggest that the anticarcinogenic and anti- inflmmatory
properties of curcumin may be related to its ability to inhibit cellular gene
expression regulated by transcription factors NF- kappa B, AP- 1, and Egr- 1.
PMID: 9437186- 3 Researchers
UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
DEPARTMENT OF MOLECULAR ONCOLOGY
Aggarwal BB. 1998
Our results demonstrate that the anti- inflammatory properties of curcumin may
be attributable, in part, to inhibition of leukocyte (white blood cell)
recruitment. (Curcumin was also found to inhibit TNF activated NF- Kappa B, a
pathway which can lead to pathological inflammation and cancer proliferation).
Curcumin should be explored for its therapeutic value in atherogenesis,
bacterial sepsis, inflammation, and tumor metastasis. PMID: 9586949- 4 Researchers
UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
DEPARTMENT OF BIOIMMUNOTHERAPY
Aggarwal BB. 1997
Pharacologically safe compounds that can inhibit the proliferation of tumor
cells have potential as anticancer agents. Curcumin, a diferuloylmethane, is a
major active component of the food flavor turmeric (Curcuma longa) that exhibits
anticarcinogenic properties in vivo... Overall our results suggest that curcumin
is a potent antiproliferative agent for breast tumor cells and may have
potential as an anticancer agent. PMID: 9215611- 4 Researchers
UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
DEPARTMENT OF MOLECULAR ONCOLOGY
Aggarwal BB.
1995 (Curcumin was also found to inhibit a pathway leading to NF- Kappa B, a cascade
which can lead to pathological inflammation and cancer proliferation). PMID:
7559628- 2 Researchers
BHARAT B. AGGARWAL, 1995.
In the present report we demonstrate that curcumin (diferuloylmethane), a known
anti- inflammatory and anticarcinogenic agent, is a potent inhibitor of NF- kB
activation. 2 Researchers
UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF HUMAN BIOLOGICAL CHEMISTRY AND GENETICS,
Awashi YC. 2003
…kept on a diet supplemented with only 0.005% (w/w) curcumin had significantly
less opacification of lenses… PMID: 10814889 – 6 Researchers
UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF INTERNAL MEDICINE
Awashi YC. 1999
Curcumin, an antioxidant present in the spice turmeric (Curcuma longa) , has
been shown to inhibit chemical carinogenesis in animal models and has been shown
to be an anti- inflammatory agent. Taken together, these results suggest that
GSTs (specific detoxification enzymes) play a major role in detoxification of
lipid peroxidation products…and that these enzymes are (positively) modulated
by curcumin. PMID: 10514034- 7 Researchers
UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF HUMAN BIOLOGICAL CHEMISTRY AND GENETICS
Perez- Polo Jr. 1999
(Curcumin is being studied for its positive influence on AP- 1, a protein which
can play a pathophysiological role in the proliferation of cancer cells and
inflammation). PMID: 10555784- 3 Researchers
UNIVERSITY OF TEXAS MEDICAL BRANCH
DEPARTMENT OF INTERNAL MEDICINE, GALVESTON,
Awasthi S. 1998
Our results suggest that induction of enzymes involved in the detoxification of
the electrophilic products of lipid peroxidation may contribute to the anti-
inflammatory and anti- cancer activities of curcumin. PMID: 9675878- 6 Researchers
UNIVERSITY OF TEXAS MEDICAL BRANCH
AWASHI YC.
Curcumin treatment caused a significant induction of the glutathione S-
transferase (GST) isozyme (detoxification enzyme)…and these studies suggest
that curcumin may be an effective protective agent against cataractogenesis
(formation of cataracts) induced by lipid peroxidation (oxidation of fat). PMID:
8901798- 6 Researchers
UNIVERSITY OF TOLEDO
COLLEGE OF ART & SCIENCES
Jankun J. 2001
Understanding how curcumin inhibits lipoxygenase may help in the development of
novel anti- cancer drugs used for treatment where lipoxygenases are involved.
PMID: 11029517- 4 Researchers
WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF MEDICINE
Majumdar AP. 2001
Curcumin appears to exert its anticarcinogenic properties by inhibiting
proliferation and inducing apoptosis in certain gastric and colon cancer cells.
PMID: 11396178- 3 Researchers
YALE UNIVERSITY SCHOOL OF MEDICINE
DEPARTMENT OF PHARMACOLOGY
Sartorelli AC. 1997
Curcumin, a potent inhibitor of tumor promotion and of tumor cell growth, has
also been shown to have antioxidant properties and to inhibit NF- kappa B (NF-
Kappa B is a pathway which can lead to pathological inflammation and abnormal
cancer proliferation)...Curcumin caused a marked reduction in NF- kappa B
activity in nuclear extracts of HL- 60 cells (human leukemia cell line) exposed
to this agent… PMID: 9112258- 3 Researchers
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