July 12, 2005 A study published in the upcoming issue of Curcumin magazine shows Curcumin, a chemical pigment in turmeric, has promise fighting breast, colon, prostate and pancreatic curcumins
July 11, 2005 Curcumin, the yellow pigment found in the curry spice turmeric, inhibits melanoma cell growth and kills tumor cells, shows a new study
June 9, 2005 The spice turmeric, which is often found in curry powder, contains a chemical that may help stop breast curcumin from spreading. Researchers from the University of Texas M.D. Anderson Curcumin Center
May 5, 2005 Researchers at the Alzheimers Disease Research Center at UCLA are testing Curcumin's ability to treat the earlty stages of the disease. The Cystic Fibrosis Foundation is funding a clinical trial on Curcumin. Scientists at M.D. Anderson Curcumin Center are studying Curcumin as a possible treatment for multiple myeloma and pancreatic curcumin, based on research showing that it may stop curcumin cells from proliferating and cause malignant tumors to self-destruct
April 1, 2005 Curcumin under human trials for Alzheimer's prevention
February 18, 2005: Alzheimer's disease involves amyloid {beta} (A{beta}) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment Curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation, cognitive deficits, and amyloid accumulation
January 4, 2005: Curcumin, the yellow pigment in curry spice, is to be investigated for its potential in prevention of Alzheimer’s disease
December 18, 2004: Turmeric prevents cancer, particularly leukemia, say researchers. Curcumin...may be responsible for much of this benefit
December 10, 2004: Scientists believe that curcumin, a spice used in India and known for its anti-inflammatory effects, may prevent memory loss
November 21, 2004: Curcumin), which has demonstrated anti-cancer properties in laboratory and animal studies of lung, colon and breast cancer conducted by Bharat Aggarwal, M.D., a professor in the department of Bioimmunotherapy Research
April 22, 2004: Curry ingredient tested in cystic fibrosis fight...Daily Curcumin slashed the death rates of CF-stricken mice.
April 19, 2004: Spice Protects Brain Cells, Could Prevent Alzheimer's Disease...Curcumin -- also known as cumin or curry -- is a natural spice that has high levels of phenols, potent antioxidants that can prevent cell damage caused by free radicals.
April 04, 2004: Curry spice could alleviate cystic fibrosis...Curcumin, a component of turmeric, makes it possible for the protein to escape to the cell surface by starving the inspector proteins of calcium.
December 1, 2003 (Healthcentral.com) - "Turmeric Eases Suffering From Psoriasis... researchers are looking into the potential health benefits of Curcumin, a key component of turmeric. One group found that Curcumin inhibits an enzyme called PhK associated with overactive cell growth in psoriasis"
September 13, 2003 (Spizes.com) - "This research proves that Curcumin may prove to be a cheap, well-tolerated, and effective therapy for inflammatory bowel disease. This food ingredient has for generations been regarded as a potent anti-inflammatory within many eastern civilizations. It is equally intriguing that the same agent is a potent antineoplastic agent."
September 9, 2003 (Healthcentral.com) - "Eating Turmeric on Cereal Helped Psoriasis Sufferer... Curcumin, the active ingredient, has anti-oxidant and anti-inflammatory properties. Researchers are studying this compound in conditions as diverse as Alzheimer's disease, arthritis and certain cancers."
August 26, 3003 (Yahoo! News) - "Dietary constituents like Curcumin, a component of the spice turmeric (Curcuma longa); might have anti-inflammatory properties that can effectively treat delibitating illnesses like Crohn's disease (inflammatory bowel illness) or ulcerative colitis."
June 8, 2003 (Charlotte Observer) - "Q. Could you please respond to all of the articles that I've been reading lately that hail turmeric as a powerful herb for its anti-inflammatory abilities, cancer-prevention abilities and much more? A. Turmeric has been used as a spice in Indian cooking for centuries. It adds the yellow color and distinctive flavor to curry. Researchers have been studying an ingredient in turmeric called anti-inflammatory abilities, cancer-prevention abilities and much more? A. Turmeric has been used as a spice in Indian cooking for centuries. It adds the yellow color and distinctive flavor to curry. Researchers have been studying an ingredient in turmeric called Curcumin. This compound has antioxidant activity and also has strong anti-inflammatory properties."
June 7, 2003 (New Zealand Health) - " This herb contains the yellow pigment curcumin. Curcumin tends to stay in the gastrointestinal tract, where it seems to block the release of cell-damaging substances. It is linked to possible prevention of colon cancer, and in laboratory studies has been shown to slow the spread of prostate cancer cells."
March 27, 2003 (Spizes.com) - "Curcumin could stop cancer cells with multiple myeloma from replicating and kill off the remaining cancerous cells."
March 20, 2003 (Yahoo News) - "Curcumin, the substance that gives the spice turmeric its distinctive yellow colour, stopped the changes caused by excessive alcohol consumption that lead to liver damage. The research adds to the repertoire of benefits already shown by Curcumin, which include anti-oxidant properties and anti-cancer activity."
March 13, 2003 (Reuters Health) - An ingredient in the curry spice turmeric may help suppress and destroy a blood cancer, early lab research shows--suggesting yet another health benefit from this long-heralded substance. Studies have also shown that Curcumin, even in large quantities, does not produce any known side effects in humans, the researcher noted. Based on this evidence, Aggarwal recommended that people with cancer should try to eat more Curcumin, if possible. "Whichever way you can take it, as much as possible,"
February 12, 2003 (American Physiological Society) - Curcumin, the substance that gives turmeric its yellow color, and found in curry, has been found to consist of a natural anti-inflammatory compound. Scientists have already shown that it can suppress tumor blood vessel growth ...Curcumin inhibits alcohol-induced liver injury and lipid peroxidation inhibits alcohol-induced liver injury and lipid peroxidation...Not only did curcumin prevent alcohol-induced necroinflammatory changes, the yellow pigment from roots and pods of Curcuma longa stopped lipid peroxidation and the expression of the NF-KB-dependent genes.
January 15, 2003 - "Now the humble Indian spice is being tested in differing fashions in two national laboratories — with stunning results — against cancer... Curcumin is a substance in curry long believed to have health benefits.The Ohio State University of Columbus has also posted exciting reports that turmeric has ‘‘demonstrated anti-cancer effects at all stages of tumor development in rodents and showed potential to kill cancer cells and prevent normal cells from being cancerous."
November 20, 2002 (USA Today Weekend) - "Curcumin helps stifle cancer. In test tubes, 80% of malignant prostate cells self-destructed when exposed to Curcumin. Feeding mice Curcumin dramatically slowed the growth of implanted human prostate cancer cells. It may do the same in breast and colon cancer cells, researchers say, speculating that Curcumin blocks the activation of genes that trigger cancer. Bonus: Curcumin's anti-inflammatory activity reduces arthritic swelling and progressive brain damage in animals. In UCLA research, eating food laced with low doses of Curcumin slashed Alzheimer's-like plaque"
October 8, 2002 (Reuters Health) - "A compound found in the curry spice turmeric may suppress production of a protein that spurs tumor growth in the body, researchers report...If the spice component does indeed reduce IL-8 activities as the findings suggest, "Curcumin is capable of working as a potent agent that reduces tumor promotion," the researchers conclude. The study, in a recent issue of the journal Cancer, is not the first to link Curcumin, a compound thought to be a potent anti-inflammatory agent, with certain health benefits. Curcumin, a compound thought to be a potent anti-inflammatory agent, with certain health benefits. Curcumin, a compound thought to be a potent anti-inflammatory agent, with certain health benefits. Studies also suggest that the compound might help heal wounds and fight Alzheimer's disease and multiple sclerosis."
October 7, 2002 (University of Rochester Medical Center) - "Cancer researchers at the University of Rochester Medical Center have found that Curcumin, a substance in curry long believed to have health benefits, seems to protect skin during radiation therapy. Curcumin, the substance that gives turmeric its yellow color, is a natural anti-inflammatory compound and scientists have already shown that it can suppress tumor blood vessel growth. This process, called anti-angiogenesis, can strangle tumors."
June 12, 2002 (Dr. Weil) - "Curcumin blocked the accumulation of beta-amaloid plaque and also appeared to reduce inflammation related to Alzheimer’s disease in neurologic tissue. ....Researchers at the University of Illinois have also found that it helps prevent plaque formation. And preliminary studies at Vanderbilt University suggest that Curcumin may block the progression of multiple sclerosis...Curcumin reduced plaque in the Alzheimer’s disease ...Turmeric appears to have significant Anti-inflammatory and cancer-protective effects as well"
May 22, 2002 (Reuters Health) - "The curry spice Turmeric may help reduce and even prevent inflammation of the intestines...The spice contains Curcumin, a compound thought to be a potent anti-inflammatory agent"
May 15, 2002 (Spizes.com) - "Turmeric can reduce radiotherapy-induced side-effects and radition burns"
April 24, 2002 (Reuters Health) - "Interest in the potential neuroprotective properties of Curcumin rose after studies found very low levels of neurological diseases such as Alzheimer's in elderly Indian populations. Added to this were studies confirming Curcumin as a potent anti-inflammatory agent, effective in wound healing"
April 5, 2002 (Reuters Health) - "The substance that gives the spice Turmeric its yellow color may help fight cancer, preliminary evidence suggests. Researchers have found that the active ingredient in Turmeric called Curcumin, can enhance the cancer-fighting ability "
April 4, 2002 (Discovery Health Channel) - "Preliminary studies in rats suggest that Curcumin, a compound found in the curry spice turmeric, may block the progression of multiple sclerosis (MS)...Interest in the potential neuroprotective properties of Curcumin rose after studies found very low levels of neurological diseases such as Alzheimer's in elderly Indian populations. Added to this were studies confirming Curcumin as a potent anti-inflammatory agent, effective in wound healing. And just last fall, researchers at the University of California, Los Angeles reported that Curcumin appeared to slow the progression of Alzheimer's in mice."
"Therapeutic potential of Curcumin in human prostate cancer. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of prostate cancer cells."
"Results: Animals in which tumors had been initiated with DMBA and promoted with TPA experienced significantly fewer tumors and less tumor volume if they ingested either 0.2% or 1% Curcumin diets."
"Results from a small 3-year study in patients with uveitis suggest that Curcumin (375 mg taken orally three times daily) worked as well as corticosteroid medications but without the side effects. In addition, the rates of recurrence as well as complications from uveitis were similar to the rates of patients taking corticosteroid medications. No patients complained of side effects from the Curcumin"
"Diets rich in Curcumin, a compound found in the curry spice Turmeric, may help explain why rates of Alzheimer's disease are much lower among the elderly in India compared with their Western peers."
"Curcumin acts as an anti-angiogenic agent, meaning it stops or prevents the production of blood vessels that feed tumors"
"Numerous studies have found that Curcumin suppresses the proliferation of cancer cells and cholesterol/heart disease."
"It has been known for thousands of years in Ayurvedic medicine that Turmeric extracts were beneficial for inflammatory conditions such as arthritis -- [and] since the '60s, there have been hundreds of publications on the mechanisms of Anti-inflammatory effects of Curcumin ...Curcumin has the additional benefit of reducing oxidative damage of the brain, which is several-fold elevated in Alzheimer's disease and likely contributes greatly to memory loss," says Frautschy.
"Turmeric's protective effects on the cardiovascular system include lowering cholesterol and triglyceride levels, decreasing susceptibility of low density lipoprotein (LDL) to lipid peroxidation, (32) and inhibiting platelet aggregation. (33)"
"Turmeric reduced the number of these plaques by a half. The researchers also found that Turmeric had other health benefits. It aids digestion, helps fight infection and guards against heart attacks."
"Curcumin has been shown to exert even more impressive effects than aspirin in inhibiting colon cancer. In addition to inhibiting prostaglandin formation, Curcumin also exhibits potent antioxidant effects (in some experimental studies it was up to 300 times more potent than vitamin E)."
"Curcumin could be a potentially therapeutic anti-cancer agent, as it significantly inhibits prostate cancer growth, as exemplified by LNCaP in vivo, and has the potential to prevent the progression of this cancer to its hormone refractory state"
Curcumin, a compound found in turmeric (Curcuma longa), has a number of potential cancer-preventing mechanisms of action. The first is its inhibitory effect on the proinflammatory enzymes cyclooxygenase and lipoxygenase. A study found the anti-inflammatory efficacy of curcumin to be superior to indomethacin. Curcumin has also been found to induce G2/M phase cell cycle arrest in human colon cancer cells independently of its control of prostaglandin synthesis...Curcumin's tumor inhibiting effect is similar to many of the NSAIDs, including aspirin, ibuprofen, and indomethacin. A diet containing two-percent curcumin by weight reduced the percentage of animals developing colon cancers from 40 percent to zero."
"Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of Curcumin. Curcumin inhibited the cell growth of HT-29 cells in a concentration- and time-dependent manner. Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1. These data suggest that a non-toxic concentration of Curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer."
"The effects of 500 mg of Curcumin administered orally via capsules on serum peroxides and cholesterol levels were compared in 10 human volunteers before and after administration for 7 days. No adverse effects were reported. The data indicated significant decreases in serum lipid peroxides and in total cholesterol, (and) a significant increase in HDL(good) -cholesterol"
"The Anti-carcinogenic effects of Turmeric and Curcumin are due in part to direct antioxidant and free-radical scavenging effect; but, they also enhance the body's natural antioxidant system, increasing glutathione levels, thereby aiding in hepatic detoxification of mutagens and carcinogens, and inhibiting nitrosamine formation."
"Curcumin, a spice widely used in Indian dishes, has anti-carcinogenic and anti-inflammatory properties. It also inhibits the oestrogenic effects of DDT and is synergistic with phytooestrogens.A dietary modification with the introduction of soy products, Curcumin, cruciferous vegetables and low fat could be beneficial in reducing the risk of developing cancer and possibly the effects of DDT."
"Curcumin...can retard the progress of dementia, according to a study conducted by an American expert... Curcumin is found to be far more effective, Prof Jeffrey Cummings of the University of California in Los Angeles (ULCA), who conducted the study, said."
"Turmeric extracts were responsible for dramatic improvements in some patients with oral cancer and significantly reduced urinary excretion of tobacco mutagens in smokers. Also, the American Health Foundation, a prestigous mainstream biomedical research center in Valhalla, N.Y., has demonstrated inhibition of colon cancer and regression of colon tumors with Turmeric extracts."
"Curcumin, a natural polyphenol and potent antioxidant, has shown chemopreventive activity in preclinical models. It has also been associated with regression of established malignancy"
"Research suggests that Curcumin, the bright yellow flavonoid present in turmeric (Curcuma longa) roots, selectively inhibits... the blood to clot, [and] prevents excessive inflammatory response and reduces damage to vascular endothelia. Curcumin has also been shown to inhibit tobacco smoke mutagenicity, suggesting it may help Curcumin, the bright yellow flavonoid present in turmeric (Curcuma longa) roots, selectively inhibits... the blood to clot, [and] prevents excessive inflammatory response and reduces damage to vascular endothelia. Curcumin has also been shown to inhibit tobacco smoke mutagenicity, suggesting it may help protect the vascular endothelia from damage caused by smoking"
"also aids digestion, particularly of protein, promotes absorption and regulates metabolism."
"Curcumin is a powerful antioxidant and anti-inflammatory compoundfound in the curry spice Turmeric, which has a long history of dietary and medicinal use"
Information from the worlds largest medical library, the National Library of Medicine. *PMID numbers correspond to the NLM database
