"Piperine has been found to increase the bioavailability of curcumin significantly. Curcumin (oral, 1 g/d plus piperine 10 mg/day for 12 weeks) reduced cardiovascular risk and enhanced antioxidant capacity in type 2 diabetes mellitus through decreasing serum levels of total cholesterol and non-HDL-cholesterol." - Pharmacological Research | 2023

"Piperine increased the bioavailability of curcumin by 154%. Curcumin combined with piperine exhibited higher intestinal absorption (78%). When co-administered with piperine, the half-life of curcumin was increased from 12.8h to 28.9h. Co-administration of piperine (20 mg/kg) and curcumin (2 mg/kg) increased the plasma concentration of curcumin in a short time, i.e. within 1-2h, peak time was increased, elimination half-life decreased, and clearance decreased.  In humans, even with a 2g load of curcumin, the serum level was undetectable. A higher extent of absorption and higher bioavailability of curcumin (2000%) was observed in humans using 20mg piperine." - Review of Curcumin and Its Different Formulations: Pharmacokinetics, Pharmacodynamics and Pharmacokinetic-Pharmacodynamic Interactions | 2023

"Piperine is known to enhance curcumin absorption and tissue uptake, while also reducing curcumin hepatic metabolism. Once absorbed, curcumin is metabolized within the epithelial cells and/or effluxed back into the intestinal lumen. This efflux is thought to occur due to the presence of efflux transporters within the intestinal cell membranes. Piperine from black pepper, as well as certain catechins from green tea, are able to inhibit these transporters, thus increasing the amount of curcumin that remains in the body. A preclinical study administrated an orally delivered powder of curcumin (2 g/kg/day) and piperine (20 mg/kg/day) and concluded that piperine significantly increases the serum concentration of curcumin, resulting in a 154% improvement in its relative bioavailability. Similarly, a clinical study conducted with the combined oral administration of curcumin and piperine dissolved in water (2 g of curcumin powder, 20 mg of piperine and 150 mL of water). The study found that piperine significantly increased the serum concentration of curcumin, resulting in a relative bioavailability increase of 2000%" - Effect of Curcumin Consumption on Inflammation and Oxidative Stress in Patients on Hemodialysis: A Literature Review | 2023

"The bioavailability of curcumin was significantly increased by 2000% when piperine, which is extracted from black pepper, was also taken as a supplement." - Effect of Curcumin and Coenzyme Q10 Alone and in Combination on Learning and Memory in an Animal Model of Alzheimer’s Disease | 2023

"Piperine is an adjuvant that can greatly improve bioavailability of curcumin. Piperine slows the metabolism of curcumin by inhibiting hepatic and intestinal glucuronidation. Previous studies have shown that administering curcumin with piperine can increase serum concentrations of curcumin by up to 2000%, indicating that glucuronidation inhibition may be the major mechanism of increasing curcumin bioavailability. As such, the formulation of the supplement administered in the current study, 1,400 mg of curcumin and 10 mg of piperine, may have helped to increase serum concentrations of curcumin such that it could exert its biological action." - Frontiers in Nutrition, Sport and Exercise Nutrition | 2023

"The study has found that curcumin (oral, 1 gram per day plus piperine 10 mg/day for 12 weeks) reduced cardiovascular risk and enhanced antioxidant capacity in T2DM through decreasing serum levels of TC, non-HDL-c and MDA, while also increasing serum adiponectin, SOD or HDL-C levels." - Pharmacological Research | 2023

"The combination of curcumin with piperine has better gastrointestinal absorption and reduces curcumin's systemic excretion. Piperine increases the bioavailability of curcumin by binding to the enzyme glucuronidase in the intestine, preventing glucuronidation and reducing the excretion of curcumin from the stool" - The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density | 2023

"Curcumin + piperine decreased waist circumference, systolic blood pressure, total cholesterol, low-density lipoprotein-cholesterol, fasting blood glucose, alanine transaminase and aspartate transaminase compared with placebo. Curcumin + piperine may be considered as an adjunct therapy to improve anthropometric measures, blood pressure, lipid profile, blood glucose, and liver function in Non-alcoholic Fatty Liver Disease patients." - Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis | 2023

"Curcumin-piperine supplementation for 12 weeks resulted in significant reductions in serum levels of total cholesterol, triglycerides, weight, waist circumference, and systolic and diastolic blood pressure in patients. To improve pharmacokinetic features, co-administration of curcumin with piperine has been introduced as an alternative. Piperine, which is a naturally occurring alkaloid from pepper, has been shown to increase the bioavailability of curcumin and reduce its glucuronidation." - The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial | 2023

"Recent studies demonstrated that piperine potentiates curcumin’s inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. Among the numerous candidates tested so far, curcumin, piperine and certain types of cannabinoids performed promisingly well in colon carcinoma models as monotherapy agents. Piperine, a dietary polyphenol isolated from black and long peppers, distinguished with its intrinsic features, improves not only curcumin’s existing anti-cancer activity, but also its extremely poor bioavailability. As a single agent, piperine alone also displays anti-mutagenic and anti-tumor activities." - Frontiers in Pharmacology | 2023

"Several studies done by using curcumin in conjunction with various anticancer compounds, as in piperine...have shown significant suppression, reduction/inhibition of IL-6, IL-1β, IL-19, TNF-α and COX-2 (Al-Dossari et al., Citation2020; X. Q. Hu et al., Citation2016; Neyrinck et al., Citation2013; Tremmel et al., Citation2019; Yan et al., Citation2019)." - Curcumin: recent updates on gastrointestinal cancers | 2023

"Black pepper piperine is one of the most effective boosters of curcumin bioavailability. The simultaneous administration of curcumin and piperine to humans or animals boosted the serum levels by more than a thousandfold. Piperine contained in black pepper can improve the uptake of curcumin by 2,000% (20 times). The vast metabolism of turmeric in the hepatic tissues and intestinal walls increased its bioavailability, which improved through piperine. Taking these two substances with an oil rich in unsaturated fatty acids further strengthens this benefit. Zeng et al. examined the effect of piperine pre-administration on oral curcumin bioavailability. In this investigation, rats were given 20 mg/kg piperine first, followed by 200 mg/kg curcumin at intervals of 0.5–8 h after piperine treatment. The pre-treatment with piperine before curcumin administration significantly increased curcumin oral bioavailability in all tested rats. Recent research suggests that oral administration of curcumin and piperine for symptomatic COVID-19 therapy might dramatically reduce mortality and morbidity (53). The conjugation between piperine and curcumin may be a safe and natural option for preventing post-COVID symptoms." - Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review | 2023

"The combination of Curcumin with piperine was associated with a 2000% improvement in Curcumin bioavailability." - Health Science Reports | 2023

"Another promising approach is the simultaneous administration of curcumin with piperine, an alkaloid from black pepper and long pepper. Piperine significantly increases the bioavailability of curcumin—up to 2000%—by preventing its metabolism." - An Overview of the Enhanced Effects of Curcumin and Chemotherapeutic Agents in Combined Cancer Treatments | 2023

"Curcumin has received worldwide attention for its multiple health benefits, which are best achieved when curcumin is combined with agents such as piperine to increase its bioavailability significantly. Pawar et al reported that the administration of oral curcumin with piperine as symptomatic adjuvant therapy in COVID 19 treatment could substantially reduce morbidity and mortality and ease the logistical and supply related burdens on the healthcare system. Askari et al reported that 46 outpatients with COVID 19 disease were randomly allocated to receive two capsules of curcumin - piperine for 14 days. There was a significant improvement in dry cough, sputum cough, ague, sore throat, weakness, muscular pain, headache and dyspnoea in curcumin - piperine groups. Kumar et al reported that using curcumin, Piper Nigrum Piperine and catechin could cure and prevent COVID 19 outbreaks and infection. Curcumin and piperine interact and form a π–π intermolecular complex, which enhances curcumin's bioavailability." - Therapeutic potential of curcumin in ARDS and COVID 19 | 2023

"Curcumin by itself has very low bioavailability due to ineffective absorption, and fast metabolism and excretion. This issue can be solved by combining curcumin with piperine (a key active ingredient in black pepper) to create a curcumin complex that is readily absorbed and metabolized in the body. Curcumin is more active when combined with piperine to provide major health benefits. These benefits are maximized when curcumin is coupled with agents such as piperine, that significantly increase its bioavailability." - The Therapeutic Role of Curcumin in Inflammation | 2023

"Curcumin has received worldwide attention for its multiple health benefits, which appear to act primarily through its anti-oxidant and anti-inflammatory mechanisms. These benefits are best achieved when curcumin is combined with agents such as piperine, which increase its bioavailability significantly." - Department of Nutrition, Central Michigan University | 2023