Curcumin 95% Turmeric Extract + Piperine

does piperine improve absorption, enhance bioavailability, and work synergistically with Curcumin?

"Coadministration of piperine and curcumin enhances the oral bioavailability of curcumin, and thereby, its therapeutic efficacy. It has been proved that piperine can increase the delivery of curcumin to systemic circulation due to its ability to improve the pharmacokinetic profiles of curcumin. Piperine was reported to increase the bioavailability of oral curcumin: 154% and 2000% increase in curcumin concentration in the plasma was observed in rats and humans, respectively. The increased concentration of curcumin in the bloodstream is due to the ability of piperine to decrease the rate of metabolism of curcumin in the intestine and liver. In the intestine, piperine regulates membrane lipid dynamics and inhibits the intestinal metabolism of curcumin, leading to enhanced curcumin retention in the intestine. Furthermore, piperine reduces the rate of curcumin metabolism in the liver. In addition, curcumin and piperine interacted synergistically, reducing proinflammatory mediators. The combination also demonstrated better compatibility profiles with neuronal cells. Curcumin and piperine significantly ameliorate inflammation. Curcumin and piperine synergistically attenuate inflammatory response in-vitro. The curcumin-piperine combination at the highest dose exhibited significantly lesser expression of pro-inflammatory cytokines compared to the individual treatment at respective concentrations. Curcumin-piperine combination showed better compatibility with neuronal cells compared to individual treatments. The combination of curcumin and piperine synergistically interacts in suppressing pain. Curcumin and piperine interacted synergistically, suppressing inflammatory mediators with favorable compatibility with neuronal cells. The combination of curcumin and piperine elicited a greater antinociceptive effect compared to that of either curcumin or piperine alone." - CM Journal | 2022

"Curcumin-piperine supplementation led to fewer thromboembolic episodes following recovery from COVID-19 infections." - Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials, Nutrients | 2022

"The combination of curcumin and piperine had synergistic additive effects. Furthermore, the combination of piperine and curcumin can enhance the bioavailability of curcumin in human and animal models.The absorption, distribution, metabolism, excretion, and toxicity of a therapeutic could be achieved by combining with bioenhancers like piperine." - Evidence-Based Complementary and Alternative Medicine | 2022

"The most common way to increase curcumin’s poor pharmacokinetic profile is the combination of curcumin with the natural alkaloid of black pepper—piperine (Piper nigrum) that is a strong inhibitor of glucuronidation process. This formulation resulted in 3-fold increase of curcumin concentrations, as compared to pure curcumin, when 5 mg of piperine was added to 2 g of curcumin." - Curcumin in Ulcerative Colitis - Current Overview, Nutrients | 2022

"Piperine can increase the uptake of curcumin. The most important findings of this study were the administration of curcumin associated with piperine can inhibit the elevation of plasmatic levels of some cytokines. This result shows the capacity of curcumin to modulate an inflammatory response acutely induced by exercise. The anti-inflammatory action of curcumin associated with piperine prevented the expression of inflammatory cytokines. Supplementation of 500 mg curcumin with piperine for seven days was able to inhibit the inflammatory response after an experimental protocol of running on a treadmill until voluntary fatigue." - The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study, Biology | 2022

"Studies have shown that using higher oral doses of curcumin results in appropriate levels of curcumin necessary for clinical activity. Coadministration with piperine, an extract of black pepper or with lecithin can enhance solubility, and the former can increase plasma bioavailability by up to 2000%." - A Review On Curcuma Longa Effect On Human Health, Journal of Emerging Technologies and Innovative Research | 2022

"Piperine behaves as a bio-enhancer and inhibits drug-metabolizing enzymes to aid curcumin absorption and bioavailability. It has numerous pharmacological effects and some health benefits, particularly against chronic diseases (decrease in insulin resistance, anti-inflammatory properties, amelioration of hepatic steatosis. Shoba et al. reported that curcumin bioavailability improved by 2000% at 45 min after concomitant orally administrated piperine." - Molecules | 2022

"A study examined the effects of curcumin combined with piperine (from black pepper extract used to improve the bioavailability of curcumin) as an add-on to the ongoing antipsychotic treatment. At the end of 16 weeks, both groups showed significant improvements in total scores and general psychopathology subscale of the Positive and Negative Syndrome Scale (PANSS). Both the doses were tolerated well without much adverse effects." - Role of Curcumin in the Management of Schizophrenia: A Narrative Review | 2022

"Improvement in weakness was more in the curcumin-piperine group than with placebo group. Conclusion: The present study results showed that curcumin-piperine cosupplementation in outpatients with COVID-19 could significantly reduce weakness." - The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial, Trials | 2022

"For centuries, turmeric containing curcumin and Piper nigrum containing piperine have been used as food additives and folk medicine, including Traditional Chinese Medicine. Curcumin and piperine have been shown to interact synergistically in various preclinical pharmacological studies. Many recent studies reported synergistic effects of curcumin and piperine combination in various pharmacological models, including lung cancer, aging, and hepatocellular carcinoma. Pharmacodynamically, the combination of curcumin and piperine could simultaneously inhibit multiple sites of action in the pain pathway. The ability of curcumin and piperine to modulate diverse pathways of pain could lead to robust inhibition of pain transmission when those are coadministered." - CM Journal | 2022

"Piperine, an alkaloid responsible for the pungency of black pepper, dramatically increases the serum levels of curcumin in rats and humans." - Protective Effects of Curcumin in Cardiovascular Diseases - Impact on Oxidative Stress and Mitochondria, Cells | 2022

"Piperine together with curcumin could improve its bioavailability and make its anti-epileptic action even more effective." - New Promising Therapeutic Avenues of Curcumin in Brain Diseases, Molecules | 2022

"Piperine (found in black pepper) increases your body's ability to hold onto curcumin by up to 2,000%. Piperine slows down the metabolization of turmeric's active compound, leaving it available for your body to absorb. If you're going the supplement route, it's best to choose options that also contain piperine to improve the potential effects." - The Untold Truth Of Turmeric, Mashed | 2022

"Curcumin + piperine treatment was associated with a significant reduction in the mean serum levels of immunoglobulin E (IgE). Curcumin plus piperine might have positive effect on serum immunoglobulin E (IgE) levels." - Effects of curcumin-piperine supplementation on systemic immunity in young women | 2022

"There is evidence that the combination of piperine in black pepper with curcumin in turmeric increases the bioavailability of curcumin by 2000% and inhibits the intestinal and hepatic glucuronidation of curcumin." - Curcumin-Rich Curry Consumption and Neurocognitive Function from 4.5-Year Follow-Up of Community-Dwelling Older Adults, Nutrients | 2022

"Bioavailability enhancer curcumin-piperine considerably increased the curcumin blood levels." - Role of Curcumin in Retinal Diseases, Clinical and Experimental Ophthalmology | 2022

"One pilot study concluded that an oral dosage of 500 mg of curcumin with piperine could restore lipid peroxidation in patients suffering from tropical pancreatitis." - A Comprehensive Review on the Therapeutic Potential of Curcuma longa in Relation to its Major Active Constituent Curcumin, Frontiers in Pharmacology | 2022

"Piperine, a bio-enhancer improves the absorption of curcumin. Of note, piperine (10 mg/day) was used to increase the bioavailability of curcumin." - An Update on the Exploratory Use of Curcumin in Neuropsychiatric Disorders, Antioxidants | 2022

"Concomitant administration of piperine with curcumin significantly reduced elimination and half-life clearance of curcumin. Perkins and colleagues reported that humans require a daily dose of 1.6 g curcumin to achieve the desired results." - Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature | 2021

"Piperine, a bio-enhancer, considerably improves the absorption of curcumin." - Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial, Frontiers in Pharmacology | 2021

"Piperine is a natural alkaloid that is found in black pepper (Piper nigrum), which is capable of increasing the bioavailability of curcumin by inhibition of biotransformation—especially glucuronidation - in the liver and small intestine. As Hewlings and Kalman emphasized in their work, piperine has been associated with an increase in the bioavailability of curcumin by 2000%." - Curcumin and Its Potential Impact on Microbiota, Nutrients | 2021

"The protective action of curcumin and piperine consumption is associated with weight loss, anti-inflammatory potential, and control of prostate epithelial cell homeostasis." - Protective effect of the association of curcumin with piperine on prostatic lesions: New perspectives on BPA-induced carcinogenesis, Food and Chemical Toxicology | 2021

"Combined with piperine, curcumin can synergistically improve anti-inflammatory and antioxidant activity. Combinations of curcumin with piperine have been successfully used for the bio-enhancement of curcumin." - Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases | 2021

"Piperine, a pungent alkaloid recovered from black pepper, enhances bioavailability of curcuminoids Improved gastrointestinal absorption and bioavailability of curcumin has been observed using other plant bioactive components such as piperine. Short-term supplementation with a curcuminoid-piperine combination also improves oxidative stress and inflammatory status in metabolic syndrome patients." - Turmeric and its bioactive constituents trigger cell signaling mechanisms that protect against diabetes and cardiovascular diseases, Molecular and Cellular Biochemistry | 2021

"In the case of curcumin, there has been a great interest in piperine owing to its ability to decrease curcumin hepatic and intestinal glucuronidation with consequent augmentation of curcumin bioavailability. This pharmacological effect was demonstrated by comparing serum curcumin concentration when given alone versus administration together with piperine. In this last case, curcumin blood levels presented a significant increase." - Anti‑inflammatory role of curcumin in retinal disorders, Experimental and Therapeutic Medicine | 2021

"The bioavailability of curcumin can be increased by 2000% when using piperine as an adjuvant." - Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro, Viruses | 2021

"Curcumin supplements are commonly produced in capsule form with piperine, or black pepper extract, which increases curcumin absorption and bioavailability. This combination is therefore proffered as the ideal formulation." - Turmeric as a Possible Treatment for COVID-19-Induced Anosmia and Ageusia, Cureus | 2021

"A way to improve bioavailability would be through piperine, as demonstrated by Delecroix et al. who included 6g of curcumin + 60mg of piperine/day. Piperine is a thermonutrient that exerts its thermogenic action on the epithelial cells of the small intestine, increasing the rate of nutrient absorption and therefore increasing its bioavailability." - Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population, Nutrients | 2020

"The naturally occurring molecules curcumin and piperine suppressed the growth of and inhibited the migration and invasion of the leukemia cells, indicative of their anticancer potential. Curcumin is a polyphenolic pigment generally obtained from Curcuma longa while piperine is an alkaloid generally isolated from Piper nigrum. Both of these naturally occurring compounds have been shown to exhibit enormous anticancer potential and have been utilized in the traditional healthcare systems in the management of abnormal human conditions. They have also been shown to exhibit potent bioactivities which also include their anticancer properties. Curcumin has been shown to suppress the growth of pancreatic cancer. It has also been shown to cause inhibition of proliferation of prostate cancer cells via induction of apoptosis. Similarly, piperine has been shown to inhibit the growth of colon cancer cells and trigger apoptosis in lung cancer cells." - Antiproliferative potential of piperine and curcumin in drug-resistant human leukemia cancer cells, Journal of the Balkan Union of Oncology | 2020

"Piperine, the major active component of black pepper, represents the most utilized natural agent used to improve curcumin bioavailability, by blocking curcumin metabolism in order to increase its absorption.." - Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin, Nutrients | 2020

"When curcumin is taken with piperine it can increase the bioavailability by two folds. When humans were administered 2 grams of curcumin along with 5 mg of piperine, it showed that in two hours, the bioavailability increased by two fold when compared with only curcumin consumption subjects." - Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies

"Curcumin 1000 mg/day co-administered with piperine 10 mg/day supplementation for 8 weeks led to a significant decrease in serum MDA and increase TAC and superoxide dismutase activities in subjects with type 2 diabetes mellitus." - Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial | Inflammopharmacology

"In humans receiving a dose of 2 g curcumin alone, serum levels have been either undetectable or very low, but concomitant administration of piperine was associated with an increase of 2000% in the bioavailability of curcumin. Curcumin therapy in combination with piperine was correlated with a significant reduction in the erythrocyte malondialdehyde content and a significant increase in glutathione levels in patients with tropical pancreatitis. Furthermore, the effect of piperine in enhancing curcumin's bioavailability has been shown to be much greater in humans than in rats. When curcumin was administered along with the bioavailability-enhancing agent piperine in these mice, enhancement of the antidepressant action and increased brain penetration of curcumin were observed." - Discovery of Curcumin, a Component of the Golden Spice, and Its Miraculous Biological Activities | Clinical and Experimental Pharmacology and Physiology

"Piperine, the active component of black pepper, has been shown to enhance the bioavailability of curcumin by 2000% in humans and also presents antioxidant properties, with a radical oxygen species scavenging ability and through inhibition of lipid peroxidation." - Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage | Journal of Sports Science and Medicine

"Curcumin (1 gr/day) combined with piperine for 4 weeks improved sulphur mustard-induced chronic pruritic symptoms and DLQI of 46 patients compared with placebo.The abovementioned effects may have been influenced by the association of curcumin with piperine, a well-documented bioavailability enhancer." - Potential of Curcumin in Skin Disorders | Nutrients

"The co-administration of curcumin with piperine, an alkaloid of black pepper and long pepper, significantly enhances curcumin bioavailability since piperine prevents curcumin metabolism through the inhibition of the glucuronidation processes." - Curcumin, Gut Microbiota, and Neuroprotection | Nutrients

"Curcumin benefits are best achieved when curcumin is combined with agents such as piperine, which increase its bioavailability significantly. Piperine, a known bioavailability enhancer, is the major active component of black pepper and is associated with an increase of 2000% in the bioavailability of curcumin. Therefore, the issue of poor bioavailability appears to be resolved by adding agents such as piperine that enhance bioavailability." - Curcumin: A Review of Its’ Effects on Human Health | Foods

"Piperine, a major component of black pepper, is combined with curcumin to inhibit metabolism by UDG-glucoronosyl transferase (UGTs) and thus enhance curcumin’s bioavailability" - Pharmacokinetics, pharmacodynamics and PKPD modeling of curcumin in regulating antioxidant and epigenetic gene expression in human healthy volunteers | Molecular Pharmaceutics

"When orally administered with curcumin, it was found that piperine enhances its oral bioavailability in humans. Treatment with combination of piperine and curcuminoids for 4 weeks significantly improved St. George respiratory Questionnaire (SGRQ) and COPD Assessment Test scores, elevated GSH and reduced MDA, thus improving general health-related quality of life. Panahi et al. studied the effectiveness of supplementation with a curcuminoid preparation containing piperine on measures of oxidative stress and inflammation in patients with metabolic syndrome. The results in the test group demonstrated improved serum SOD activities and reduced MDA and C-reactive protein (CRP) concentrations compared with placebo." - Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies | Applied Sciences

"The results of the present trial revealed a beneficial effect of curcuminoids plus piperine supplementation on glycemic and hepatic parameters in patients with type 2 diabetes mellitus." - Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial | Drug Research

"In this study, a significant decrease was found in both tamoxifen and endoxifen plasma concentrations during concomitant administration of tamoxifen and curcumin, compared to tamoxifen monotherapy. This effect was even more pronounced when tamoxifen was administered with curcumin and piperine." - Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen | Cancers

"Piperine augments the bioavailability curcumin by inhibiting various metabolizing enzymes. Thus piperine, being an efficacious inhibitor of drug metabolism is a powerful enhancer of absorption." - Role of Piperine as an Effective Bioenhancer in Drug Absorption | Pharmaceutica Analytica Acta

"In order to improve the oral bioavailability, curcuminoids were co-administered with piperine in a ratio of 100:1. Curcuminoids–piperine combination is an efficacious adjunctive therapy in patients with metabolic syndrome and can modify serum lipid concentrations beyond what is achieved with standard of care." - Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome | Complementary Therapies in Medicine

"Curcuminoids were co-administered with piperine to enhance the bioavailability of curcuminoids. Comparison revealed a greater effect of curcuminoids-piperine combination compared to placebo in elevating glutathione, reducing malonedialdehyde and improving CAT and SGRQ scores. Regarding the promising effects of curcuminoids on the measures of systemic oxidative stress and clinical symptoms, these phytochemicals may be used as safe adjuvants in patients suffering from chronic sulfur mustard-induced pulmonary complications." - Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard | Journal of Dietary Supplements

"Piperine given at 20 mg combined with 2 grams of curcumin increased curcumin’s total bioavailability by 20-fold and allowed detection in the serum of healthy volunteers." - Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients

"Piperine also increases the bioavailability of herbal and conventional drugs such as curcumin. Piperine increased the bioavailability of curcumin and enhanced its protective effects against chronic unpredictable stress (CUS)-induced cognitive disorder and associated oxidative damage in mice. Bioavailability-enhancing of curcumin could be due to preventive effect of piperine on the intestinal and hepatic metabolism of curcumin." - Piperine - The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations | Comprehensive Reviews In Food Science And Food Safety

"Oral curcumin with piperine can reverse lipid peroxidation efficiently in patients with tropical pancreatitis. In one such study in healthy human volunteers, the effect of curcumin combined with piperine was measured; this increased the bioavailability of curcumin by approximately 2000% without causing any adverse effects." - Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases | British Journal of Pharmacology

"Curcumin and piperine are purported to have anti-inflammatory and anticarcinogenic activities. Piperine is also known to increase the bioavailability of dietary components, including curcumin." - Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells | Journal of Nutritional Biochemistry

"Supplementation with curcuminoid-piperine combination significantly improves oxidative and inflammatory status in patients with metabolic syndrome. Curcuminoids could be regarded as natural, safe and effective C-reactive protein lowering agents." - Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome | Clinical Nutrition Journal

"The effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in healthy human volunteers. In humans receiving a dose of 2 g of curcumin alone, serum levels of curcumin were either undetectable or very low. Concomitant administration of 20 mg of piperine with curcumin, however, produced much higher concentrations within 30 min to 1 h after drug treatment; piperine increased the bioavailability of curcumin." - Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials | American Association of Pharmaceutical Scientists

"In a dose of 2g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1h post drug (P<0.01 at 0.25 and 0.5h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects." - Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers | Planta Medica