Curcumin as a Promising Neuroprotective Agent
for the Treatment of Spinal Cord Injury: A Review of the Literature
Neurospine | July
2022
Curcumin is a promising therapeutic drug for spinal cord injuries
(SCIs)treatment because it reduces the incidence of secondary injuries.
Curcumin has antioxidant and nonsteroidal anti-inflammatory pharmacological
properties. Preclinical and clinical trials have revealed its various
pharmacological activities, including its anti-inflammatory, antibacterial,
anticancer, and neuroprotective effects on neurodegenerative disorders.
Curcumin also has hepatoprotective, nephroprotective, cardioprotective,
neuroprotective, hypoglycemic, and antirheumatic activities, and its
neuroprotective activity against several neurodegenerative disorders is gaining
researchers’ attention. As an anti-inflammatory agent, curcumin suppresses the
production of many proinflammatory cytokines, including tumor necrosis
factor-alpha (TNF-α), interleukin (IL)-1, IL-8, and monocyte chemoattractant
protein 1 [8,9]. In a recent study, curcumin inhibited the hypoxia-induced
upregulation of glial fibrillary acidic protein (GFAP) and neurofilament-H
following hypoxia and downregulated the expression of proinflammatory
cytokines, such as TNF-α and IL-1. It also suppresses glial scar formation and
GFAP expression, contributing toward the development of a more favorable
environment for neurological recovery. Curcumin is a neuroprotective
polyphenolic compound that has benefits such as pluripotency, oral safety, long
usage history, and low cost. Several animal experiments have shown that
curcumin can minimize secondary injury following primary SCIs through its
anti-inflammatory, antioxidant, and stem cell mobilization properties. Curcumin
is an influential therapeutic agent that can potentially treat catastrophic
secondary injuries in the spinal cord, including inflammation, edema, free
radical injury, fibrosis, and glial scar formation. It can enhance neurological
function in rats, as measured using the BBB locomotor rating scale.
Antioxidant Potential of Phytoconstituents with Special Emphasis on Curcumin
Antimicrobial and Pharmacological Aspects of Curcumin | July
2022
The medicinal properties of turmeric, the source of curcumin, have been
known for thousands of years; however, the ability to determine the exact
mechanism(s) of action and to determine the bioactive components have only
recently been investigated. Curcumin
(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), also called
diferuloylmethane, is the main natural polyphenol found in the rhizome of
Curcuma longa (turmeric). Curcumin, a polyphenol, has been shown to target
multiple signaling molecules while also demonstrating activity at the cellular
level, which has helped to support its multiple health benefits such as
antioxidant, anti-inflammatory, antimutagenic, antimicrobial and anticancer
properties.
Curcumin improves D-galactose and normal-aging associated
memory impairment in mice: In vivo and in silico-based studies
Plos
One |
July
2022
Curcumin, a natural flavonoid, has potent antioxidant and anti-aging
properties. Curcumin significantly increased retention time (p < 0.05) and
freezing response (p < 0.05) in PA and CFC, respectively. Curcumin profoundly
ameliorated the levels of glutathione, superoxide dismutase, catalase, advanced
oxidation protein products, nitric oxide, and lipid peroxidation in mice
hippocampi. In silico studies revealed favorable binding energies of curcumin
with GSTA1, GSTO1, KEAP1, BACE1, and MAOA. Curcumin improves retention and
freezing memory in D-gal and nature-induced aging mice. Curcumin ameliorates
the levels of oxidative stress biomarkers in mice. Anti-aging effects of
curcumin could be attributed to, at least partially, the upregulation of
antioxidant enzymes through binding with GSTA1, GSTO1, KEAP1, and inhibition of
oxidative damage through binding with BACE1 and MAOA. We investigated the
detailed effects of curcumin on oxidative stress in the D-gal and
nature-induced aging mice model. Our in vivo study suggested that curcumin
improves memory and rescues learning impairment by modulating oxidative stress
levels. Furthermore, our in-silico study demonstrated that curcumin has good
binding affinities for several molecular targets implicated in redox
homeostasis. Finally, based on our in vivo and computational studies, it can be
stated that curcumin improves aging-associated memory impairment by reducing
oxidative overload in mice.
Effects of curcumin on low-density lipoprotein
(LDL) oxidation from experimental studies to clinical practice
Excli
journal
| July
2022
Curcumin is a potent antioxidant and has a strong track record in the
treatment of numerous diseases. Recent studies indicate that Curcumin exerts a
lipid-lowering effect, and can modulate the formation of atherosclerotic
plaque. Curcumin has a long history in the treatment of diseases, such as
gastric and hepatic disorders, dental problems, menstrual difficulties,
infectious diseases, malignancies, immune-related and metabolic disorders
(Sahebkar and Henrotin, 2016; Panahi et al., 2017; Bagherniya et al., 2018;
Parsamanesh et al., 2018; Gorabi et al., 2019; Mortezaee et al., 2019; Shakeri
et al., 2019; Zahedipour et al., 2020; Afshari et al., 2021; Fu et al., 2021;
Mohammed et al., 2021). Anti-inflammatory and antioxidant properties of
Curcumin, a polyphenol, have been reported in numerous studies (Menon and
Sudheer 2007; Shehzad et al., 2011; Momtazi-Borojeni et al., 2018; Farhood et
al., 2019). Curcumin can improve the lipid profile of patients by reducing
serum triglyceride (TG), LDL and total cholesterol levels significantly in
subjects with coronary artery disease. Curcumin decreases the aortic lipid
lesions and inhibits development of atherosclerotic plaques (Wongcharoen and
Phrommintikul 2009). Curcumin demonstrates antioxidant activity because the
benzene rings in the structure of the Curcumin molecule eliminate reactive
oxygen species (ROS) (Joe and Lokesh, 1994). According to cardiac-related
studies, serum levels of lipid peroxides are higher in patients with IHD;
Curcumin is able to reduce lipid peroxide concentration (Stringer et al., 1989;
Soni and Kuttan 1992). These actions could indicate that curcumin also inhibits
ox-LDL elevation. Overall, our results suggest that curcumin could be effective
in reducing LDL oxidation.
Curcumin inhibits the replication of rotavirus in
vitro
Acta Virologica | July
2022
The present study aims to determine the effect of curcumin, a natural
polyphenol compound, on rotavirus in a cell culture model. The anti-viral
activity of curcumin was evaluated by reverse-transcriptase quantitative PCR
(RT-qPCR), TCID50, and western blot techniques to assess CC50 in
curcumin-treated MA104 cells as well as EC50 and SI within the infected MA104
cell line. Our findings supported that curcumin exerted an inhibitory influence
against rotavirus in a dose-dependent manner and decreased the viral titer and
VP6 expression by ~99% at a concentration of 30 μM.
How Curcumin Targets
Inflammatory Mediators in Diabetes: Therapeutic Insights and Possible Solutions
Molecules | July
2022
Curcumin, a polyphenol derived from turmeric, is well known for its
anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Curcumin’s
anti-inflammatory and anti-oxidative activities against a wide range of
molecular targets have been shown to have therapeutic potential for a variety
of chronic inflammatory disorders, including diabetes. Curcumin’s biological
examination has shown that it is a powerful anti-oxidant that stops cells from
growing by releasing active free thiol groups at the target location. Curcumin
is a powerful anti-inflammatory agent that targets inflammatory mediators in
diabetes, and its resistant form leads to better therapeutic outcomes in
diabetes complications. Moreover, Curcumin is an anti-oxidant and NF-B
inhibitor that may be useful in treating diabetes. Curcumin has been shown to
inhibit diabetes-related enzymes, such as a-glucosidase, aldose reductase and
aldose reductase inhibitors. Through its anti-oxidant and anti-inflammatory
effects, and its suppression of vascular endothelial development and nuclear
transcription factors, curcumin has the ability to prevent, or reduce, the
course of diabetic retinopathy. Curcumin improves insulin sensitivity by
suppressing phosphorylation of ERK/JNK in HG-induced insulin-resistant cells
and strengthening the PI3K-AKT-GSK3B signaling pathway. Curcumin is an
anti-oxidant and NF-κB inhibitor that may be useful in preventing and treating
diabetes. Curcumin has been shown to inhibit diabetes-related enzymes, such as
a-glucosidase, aldose reductase, and aldose reductase inhibitors . Curcumin has
been shown to have therapeutic potential in the prevention, or delaying, of
diabetic retinopathy, by acting as an anti-oxidant and an anti-inflammatory,
and inhibiting vascular endothelial development and nuclear transcription
factors. Curcumin’s current applications for glycemia and diabetes-related
liver illnesses, neuropathy, adipocyte dysfunction, vascular diseases,
nephropathy, and pancreatic disorders were described in. Curcumin has shown
efficient anti-inflammatory, anti-apoptotic and anti-oxidant potential. In
patients with metabolic syndrome, short-term treatment with a
curcuminoid-piperine combination reduced inflammatory status dramatically.
Curcuminoids are effective, safe and natural CRP-lowering compounds. In
addition, curcumin reduces levels of inflammatory mediators and factors, such
as TNF-α, INF-γ, reduces systemic inflammatory biomarkers. such as RANTES. and
other cytokine levels. Curcumin also reduces the levels of inflammatory
cytokines, such as IL-6 and IL-1β, and targets inflammatory mediators in
insulin diabetes resistance. Curcumin restores dysfunction associated with Nrf2
that helps in diabetes resistance management. Similarly, curcumin inhibits
inflammatory signaling and the expression of Kelch-like ECH-associated protein
1 (Keap1), resulting in activation of the Nrf2 system. Curcumin metabolites
have shown significant results in diabetes mellitus treatment focusing on
inflammatory mediators.
Curcumin Increased the Sensitivity of Non-Small-Cell
Lung Cancer to Cisplatin through the Endoplasmic Reticulum Stress Pathway
Evidence-Based Complementary and Alternative Medicine | July
2022
Curcuma longa was reported to possess antitumor activity through regulating
oncogene expression, cell cycle regulation, apoptosis, tumorigenesis, and
metastasis. Recently, curcumin was found to promote chemotherapeutic efficiency
in various cancers and diseases. For instance, Zou et al. reported that
curcumin increases breast cancer cell sensitivity to cisplatin by decreasing
FEN1 expression. Lu et al. found that curcumin can increase the sensitivity of
paclitaxel-resistant non-small-cell lung cancer cells to paclitaxel through
microRNA-30c-mediated MTA1 reduction. Recently, curcumin was found to increase
effects of irinotecan through mediating the ER stress pathway in colorectal
cancer cells. Misra et al. found that curcumin regulates ER stress through cAMP
responsive element-binding protein H. Curcumin can enhance the
chemosensitizing effect of non-small-cell lung cancer cells by targeting the ER
stress pathway. Taken together, this study demonstrated curcumin can increase
DDP sensitivity of non-small-cell lung cancer cells through mediating the ER
stress pathway. The results of this study proposed a possible mechanism of
curcumin improving DDP sensitivity in non-small-cell lung cancer cells and may
shed a little light on developing the molecular targets in the ER stress
pathway to overcome the DDP resistance in non-small-cell lung cancer.
Curcumin and metformin synergistically modulate peripheral and central immune
mechanisms of pain
Scientific Reports | June
2022
Curcumin is a natural polyphenol and has beneficial therapeutic effects on
pain. Curcumin has been used as an analgesic adjuvant with several analgesic
drugs, allowing synergistic antinociceptive effects. Coadministration of
curcumin and metformin at a 1:1 fixed ratio of their ED50 doses significantly
reduced the dose required to produce a 50% effect compared to the theoretically
required dose in phase II of the formalin test with a combination index value
of 0.24. Our findings suggest that curcumin exerts synergistic
anti-inflammation with metformin with no potential CNS adverse effects.
Curcumin has been used as a traditional herbal remedy for centuries throughout
Asia due to its pleiotropic activities, including anti-inflammatory,
antioxidant, and anticancer. It is a well‐tolerated natural product causing no
or minimal toxicity in short- and long-term use. Consequently, it was declared
“generally recognized as safe” by the US Food and Drug Administration (FDA)21.
Moreover, the therapeutic effectiveness of curcumin in nociceptive,
inflammatory, and neuropathic pain has been reported in numerous animal models
and humans. Dual treatment with curcumin and metformin has been reported in
diabetic mellitus, diabetes-induced comorbidities, nephrotoxicity,
hepatocellular carcinoma, pancreatic cancer cells, and breast cancer, with the
results suggesting synergistic effects. Moreover, metformin and curcumin have
different mechanisms of action in pain modulation, which indicates the
potential for exerting greater analgesia when administered together. In
summary, this study suggests for the first time that curcumin combined with
metformin exerts synergistic anti-inflammatory effects in both in vitro and in
vivo conditions. Curcumin synergistically augmented the inhibition of nitric
oxide and proinflammatory cytokines by metformin both in RAW 264.7 macrophage
and BV-2 microglial cells. Moreover, the combined therapy using curcumin
and metformin showed no considerable CNS adverse effects in naïve mice. Hence,
this study supports the possibility of combined use of curcumin and metformin
in the treatment of pain with the least amount of medication while taking the
easiness of administration, cost of the therapy, and side effect profile of
medicines into the account.
Combined Curcumin and Luteolin Synergistically
Inhibit Colon Cancer Associated with Notch1 and TGF-β Signaling Pathways in
Cultured Cells and Xenograft Mice
Cancers | June
2022
A combination of luteolin (30 µM) and curcumin (15 µM) was selected as the
optimum combination for the study due to a low combination index of 0.25 and
its highest synergistic inhibitory effect on the growth of two human colon
cancer cell lines CL-188 and DLD-1. Consistent with in vitro results,
intraperitoneal injection of luteolin at 10 mg/kg body weight and curcumin at
20 mg/kg body weight in BALB/C Foxn nude mice for a 2-week period
synergistically inhibited CL-188 cell-derived tumor growth. Further analysis
showed that the synergistic anti-colon cancer effect exhibited by curcumin and
luteolin was mediated through the downregulation of the effector protein
Notch1, to induce growth cycle arrest, promote apoptosis, and TGF-β signaling
inhibits angiogenesis and invasion in vitro and in vivo. These data demonstrate
that a combination of curcumin and luteolin exerts an anti-colon cancer effect
through the modulation of Notch1 and TGF-β signaling pathways, well-known in
cancer growth, invasion, and metastasis.
Antioxidant Potential of
Phytoconstituents with Special Emphasis on Curcumin
Antimicrobial
and
Pharmacological Aspects of Curcumin | June
2022
Curcumin, a polyphenol, has been shown to target multiple signaling
molecules while also demonstrating activity at the cellular level, which has
helped to support its multiple health benefits such as antioxidant,
anti-inflammatory, antimutagenic, antimicrobial and anticancer properties.
Curcumin has received worldwide attention for its multiple health benefits,
which appear to act primarily through its anti-oxidant and anti-inflammatory
mechanisms. Many major diseases such as liver problem, myocardial infarction,
diabetes, cancer are believed to be associated with lipid peroxidation and thus
causing major cell damage. Curcuminoids and other polyphenols in turmeric can
ameliorate and prevent lipid peroxidation, can stabilize the cell membrane,
hence proving its significant role in prevention of atherosclerosis. Inhibitory
action of curcumin on lipid accumulation, oxidation, nitric
oxide as well as the formation of inflammatory molecules, nuclear factor-kappa
B- (NF-kB-) dependent gene expression, and its activation can thus influence
therapeutic potential of turmeric in the treatment of pancreatic, hepatic,
cancer and intestinal diseases. Curcumin can produce promisable symptomatic
relief on external cancerous lesions in human. Along with this, curcumin has
resulted to be effective in preventing and treatment of many of the
neurodegenerative disorders as a free radical scavenger including Alzheimer’s
disease. Also after giving short-term supplementation it has proved to reduce
hematuria, proteinuria, including systolic blood pressure in patients with
relapsed or refractory lupus nephritis. By referring all the literature,
Curcumin can be considered as a safe adjuvant therapy. The previous studies had
indicated that the high antioxidant properties of turmeric was found to inhibit
cellular lipid peroxidation and can also ameliorate other oxidative damage
caused by free radicals. Thus Turmeric is proven to be an important source of
high contents of flavonoids, polyphenols, tannins and ascorbic acid. Curcumin
as important phytoconstituent of turmeric varieties is and effective and
important antioxidant compound and which can be effective in management of
various diseased conditions.
Efficacy of Curcumin on Treating Cancer
Anorexia-Cachexia Syndrome in Locally or Advanced Head and Neck Cancer: A
Double-Blind, Placebo-Controlled Randomised Phase IIa Trial
Journal
of
Nutrition and Metabolism | June
2022
Curcuminoids are the extracts from curcumin, which both in vitro and in
vivo studies have shown the inhibitory effect of NF-kB through intracellular
phosphorylation. Siddiqui et al. demonstrated that 100 mg/kg of curcumin
prevented weight loss in MAC16 colon tumour mice. Moreover, the increasing dose
of curcuminoid (up to 250 mg/kg) showed a 25% increase in body weight in mice.
Additionally, Gil da Costa et al. discovered preventing myolysis in
HPV-16-infected mice from curcuminoids by the mechanism of downregulation of
NF-kB synthesis resulted in increased muscle mass or delayed muscle wasting
compared with controlled mice. For curcumin in clinical studies, Gupta et al.
showed that patients with solid cancer receiving chemotherapy and curcumin for
eight weeks showed a significant improvement in their quality of life and a
declined NF-kB level compared with the controlled arm. Recently, our previous
study showed that 800 mg/day of curcumin delayed the progression of handgrip
muscle strength loss and basal metabolic rate significantly among patients with
solid cancer, as well as there were no serious adverse events. Our study
results showed significantly improved skeletal muscle mass with the use of
curcumin compared with matching placebo, in which the difference in the percent
change in muscle mass between the groups was significant. Moreover, body fat
mass among patients treated with curcumin showed a slower decline than patients
treated with matching placebo, even though no statistically significant
difference was noted between the two groups, but the trend seems to favour
curcumin. Our study showed that patients treated with curcumin improved
handgrip strength at week 8, but loss of handgrip strength was observed in the
matching placebo group. Furthermore, in vivo studies demonstrated curcumin's
crucial significant immunomodulatory effect by stimulating PBMC proliferation
and cytokine production. Our study results supported the related in vivo study
that curcumin administration for eight weeks resulted in less lymphocyte
suppression compared with the matching placebo group. The potential role of
curcumin regarding the immunomodulatory effect should be further investigated
among patients with cancer during treatment with chemotherapy or
immunosuppressive agents. For safety endpoint, phase I studies suggested that
curcumin at a dose up to 8,000 mg once daily orally can be safely administered
without dose-limiting toxicity. Our study results demonstrated that curcumin
was well tolerated at a dose of 4,000 mg/day and showed only mild grade of
adverse events. No serious adverse events were reported.
Review of the
Effects and Mechanism of Curcumin in the Treatment of Inflammatory Bowel
Disease
Frontiers in Pharmacology | June
2022
Curcumin has been used as a traditional herbal medicine in India and
Southeast Asia for thousands of years. It is often used to treat biliary tract
diseases, anorexia, rhinitis, cough, rheumatism, and various chronic
inflammatory diseases. Due to its extensive biological activities, it has
received widespread attention from researchers in recent years. Current
researching indicates that curcumin has high medical value, including
anti-inflammatory, antioxidant, anti-tumor, anti-apoptotic, anti-fibrosis,
immune regulation and other effects, and can be used to treat a variety of
diseases (Salehi et al., 2019). It is involved in many significant genetic and
biochemical pathways (Karthikeyan et al., 2020; Moniruzzaman and Min, 2020;
Beyene et al., 2021). Curcumin is associated with many cellular targets (i.e.,
NF-κB, JAKs/STATs, MAPKs, TNF-γ, IL-6, PPARγ, and TRPV1) that effectively
reduce the progression of IBD. The research of curcumin and related
formulations for IBD treatment has surged over the decade (Kahkhaie et al.,
2019; Sharma et al., 2019; Patel et al., 2020). So far, a large number of basic
and clinical studies have shown that curcumin has the effect of treating IBD
and also can maintain the remission of IBD (Yang H. et al., 2017). In this
review, the researches of IBD genetics and pathogenesis and curcumin molecular
targets in IBD in recent years are summarized in order to provide reference for
further research and application of curcumin. Current researching indicates
that curcumin has high medical value, including anti-inflammatory, antioxidant,
anti-tumor, anti-apoptotic, anti-fibrosis, immune regulation and other effects,
and can be used to treat a variety of diseases. A large number of basic and
clinical studies have shown that curcumin has the effect of treating IBD and
also can maintain the remission of IBD. In this review, the research of
curcumin on IBD in recent years is summarized in order to provide reference for
further research and application of curcumin. At present, many researches have
proved that curcumin is safe and effective through DBPC test (Heger, 2017).
Curcumin may not fit medical chemists’ definition of the perfect drug, but many
in vitro, in vivo and clinical trials have irrefutably confirmed its medicinal
potential (Li et al., 2015; Beloqui et al., 2016; Yang et al., 2018; Yue et
al., 2019; Wei et al., 2021). We searched ClinicalTrials.gov to identify
current clinical trials evaluating curcumin treatment for IBD. A total of 10
trials were included. Three of them have been completed and five are in phase
3. Curcumin has less adverse reactions and high safety during use. As a
potential chemotherapeutic drug, it shows a good application prospect in both
basic experimental researches and clinical trials of IBD over the decades (Shapira
et al., 2018; Sadeghi et al., 2020; Sugimoto et al., 2020; Banerjee et al.,
2021).
A study on the effects of inhibition mechanism of curcumin,
quercetin, and resveratrol
Journal of Biomolecular Structure and
Dynamics |
June
2022
Curcumin is the much better inhibitor than quercetin and resveratrol for
hGR according to both in vitro and in silico studies. Curcumin, a potential
inhibitor of hGR, can be used in drug design to target the glutathione system
in cellular injury.
Curcumin as adjuvant treatment in patients with
non-alcoholic fatty liver (NAFLD) disease: A systematic review and
meta-analysis
Complementary Therapies in Medicine | June
2022
Turmeric (Curcuma longa) has active constituents in its rhizome called
curcuminoids, with the most prominent curcuminoid called curcumin. Curcumin is
acknowledged as a powerful antioxidant and anti-inflammatory agent. Curcumin is
given through an oral capsule and taken daily. Two trials’ participants
received 500 mg curcumin and 5 mg piperine/day as intervention. A review
reported that the consumption of curcumin significantly reduced liver enzymes,
decreased low-density lipoprotein and total cholesterol among non-alcoholic
fatty liver disease (NAFLD) patients. Another review found curcumin showed
significant effects on fasting blood sugar, insulin level, and homeostasis
model of assessment insulin resistance8 among women with polycystic ovary
syndrome. Curcumin is anticipated to function as antiviral drugs to treat the
current COVID-19 virus based on in vitro and in vivo studies as it showed high
inhibitory activity towards the virus. Computer simulation and molecular
docking showed the good ability of this monomer to bind to the COVID virus and
host target so that they could block the virus-host binding sites. Curcumin has
been shown to improve non-alcoholic fatty liver disease (NAFLD) severity and
increase liver steatosis resolution compared to the placebo groups. Besides
improving the liver ultrasonographic findings, curcumin also reduced serum
liver enzymes, total cholesterol, and BMI. There is no major side effect, and
our findings showed no difference in the adverse effect between the two groups.
Curcumin was also found to reduce triglycerides if taken more than eight weeks’
duration. Our meta-analysis shows that curcumin has favorable effect on
liver ultrasonographic findings, reduced serum liver enzymes, total
cholesterol, and BMI in participants with non-alcoholic fatty liver disease
(NAFLD). Therefore, promoting curcumin as an adjuvant treatment on
non-alcoholic fatty liver disease (NAFLD) patients might be justified.
Profiling of curcumin-treated T47D human breast cancer cells by a system-based
approach
Gene Reports | June
2022
This study investigated the regulatory mechanism of curcumin in breast
cancer cells. Curcumin triggers cell death-related pathways and regulates the
metabolism of lipids and apoptotic processes in T47D cells. Curcumin signature
had significant prognostic power. Regulatory network analyses found specific
proteins, microRNAs and transcription factors as the hub nodes, which
corresponded to the effects of curcumin treatment. This work provides a picture
of the cytotoxicity mechanism of curcumin and potential therapeutic targets for
treatment optimization of breast cancer.
The efficacy of curcumin-piperine
co-supplementation on clinical symptoms, duration, severity, and inflammatory
factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled
trial
Trials | June
2022
Curcumin as an anti-inflammatory agent can have a positive effect on the
control of COVID-19 complications. This study aimed to assess the efficacy of
curcumin-piperine supplementation on clinical symptoms, duration, severity, and
inflammatory factors in patients with COVID-19. Forty-six outpatients with
COVID-19 disease were randomly allocated to receive two capsules of
curcumin-piperine; each capsule contained 500 mg curcumin plus 5 mg piperine or
placebo for 14 days. The present study results showed that curcumin-piperine
co-supplementation in outpatients with COVID-19 could significantly reduce
weakness.
Curcumin attenuates vascular calcification via the exosomal
miR-92b-3p/KLF4 axis
Experimental Biology and Medicine | June
2022
Curcumin is a natural polyphenolic compound that has hypolipidemic,
anti-inflammatory, and antioxidant effects on the cardiovascular system.
Exosomes are known to have extensive miRNAs for intercellular regulation. Our
study suggests that curcumin attenuates vascular calcification.
Role
of Curcumin in the Management of Schizophrenia: A Narrative Review
Indian
Journal of Psychological Medicine | June
2022
Curcumin is a polyphenolic molecule derived from Curcuma longa. In
traditional medicine, turmeric is commonly used as an anti-inflammatory and
antiseptic agent. Its antioxidant property and low toxicity potential are
utilized in physical disorders like rheumatioid arthritis, cardiovascular
disorders, asthma, and neuropsychiatric disorders like Alzheimer’s dementia and
Parkinsonism. There are no available reports of toxicity in humans following
long-standing use of curcumin. An exploratory proof-of-concept study examined
the effects of curcumin combined with piperine (from black pepper extract–used
to improve the bioavailability of curcumin) as an add-on to the ongoing
antipsychotic treatment. Fifteen chronic schizophrenia patients were randomized
to receive 1 g vs 4 g of add-on curcumin and piperine compounds. At the end of
16 weeks, both groups showed significant improvements in total scores and
general psychopathology subscale of the Positive and Negative Syndrome Scale
(PANSS). Both the doses were tolerated well without much adverse effects. The
role of curcumin in the management of depression and bipolar disorder has been
proposed recently. Curcumin as an add-on to antidepressant drugs has been
convincingly shown to reduce depressive symptoms, compared to placebo add-on. A
recent meta-analysis supported the utility of adjunctive curcumin in the
management of depression and anxiety disorders. Notably, curcumin was tolerable
and safe in all those randomized human clinical trials. Preclinical
studies support curcumin’s role in ameliorating the metabolic side effects of
antipsychotics such as olanzapine 28 and clozapine. Also, pretreatment with
curcumin prevented the development of tardive extrapyramidal syndromes. In both
haloperidol and clozapine exposed rats, pretreatment with curcumin successfully
prevented the development to tardive orofacial movements. Curcumin’s
antioxidant, free radical scavenging, and antiapoptotic properties are
postulated to underlie this preventive mechanism. Preclinical studies also
reported curcumin’s beneficial effects in preventing and reducing
extrapyramidal and metabolic side effects. Preclinical and clinical trials
reported curcumin’s potential role in the management of schizophrenia.
Comparative Study of the Anticoagulant Activity of Zingiber Officinale and
Curcuma longa Rhizomes Extracts in Blood Samples of Normal Individuals
Pakistan Journal of Medical & Health Sciences | June
2022
The in vitro anticoagulant effect demonstrated that ginger and curcumin
extracts had equal anticoagulant activity, but curcumin has a higher
anticoagulant impact with considerable PT prolongation.
Curcumin and Related
Compounds in Cancer Cells: New Avenues for Old Molecules
Frontiers
in
Pharmacology | June
2022
Curcumin and related compounds are bioactive compounds mainly derived from
natural sources and known for years for their pleiotropic effects. These
compounds show anti-viral, anti-fungal, anti-microbial and anti-tumor effects (Chiao
et al., 1995; Beauregard et al., 2015; Balaha et al., 2021), mainly ascribable
to anti-inflammatory and antioxidant activities. Curcumin and derivatives have
been proposed as potential therapeutic agents in selected cancer types such as
prostate, colon, breast and thyroid cancer (Schwertheim et al., 2017; Mbese et
al., 2019) and their anticancer effects have been tested in vitro and in vivo
in combination with chemotherapeutic agents and radiotherapy (Yu et al., 2021).
Curcumin has shown to amplify the anticancer effects of drugs (e.g.,
doxorubicin, cisplatin, gefitinib) and radiotherapy (Tan and Norhaizan, 2019;
Ashrafizadeh et al., 2020). For instance, curcumin displays a synergistic
effect with some chemotherapeutic agents such as 5-fluorouracil and oxaliplatin
(Farhood et al., 2019) while protecting normal tissues from cell death, and
therefore without side effects.
Effect of Interval Training and Curcumin on
BAX, Bcl-2, and Caspase-3 Enzyme Activity in Rats
Gene, Cell and
Tissue |
June
2022
Curcumin is a polyphenol used as a painkiller, anti-inflammatory agent, and
a source of powerful antioxidants. Numerous studies have confirmed the
biological effects of curcumin and introduced it into various pathological
conditions. It contains many anti-diabetic, anti-tumor, anti-inflammatory, and
antioxidant agents. Curcumin activates the caspase-3 enzyme and releases
cytochrome c from the mitochondria to the cytosol. Also, curcumin can improve
athletic performance and delay exercise fatigue. Studies have shown that
curcumin synergizes with 5-fluorouracil and enhances apoptosis in cancer cells
in xenograft mice. If curcumin enters cancer cells, it activates programmed
cell death pathways. High-intensity interval training did not reduce BAX
protein, but the training and curcumin supplementation increased Bcl-2 protein
expression and neutralized the BAX effect. Curcumin supplementation combined
with intense interval training resulted in synergy and reduced cell programming
mortality. Therefore, curcumin supplementation and intermittent exercise can
reduce cell apoptosis and programmed cell death.
Curcumin Blocks High
Glucose-Induced Podocyte Injury via RIPK3-Dependent Pathway
Frontiers
in
Cell and Developmental Biology | June
2022
Curcumin, a natural hydrophobic polyphenol compound responsible for the
yellow color in Curcuma longa, has gathered attention from various research
fields due to its natural antioxidant, anticancer, anti-inflammatory,
antiangiogenic, and antiapoptotic effects (Gururaj et al., 2002; Majithiya and
Balaraman, 2005; Koeberle et al., 2009; Perrone et al., 2015; Zhang et al.,
2020). The effect of curcumin on high glucose-induced podocyte injury has been
discussed in few studies, mainly focusing on curcumin’s antioxidant and
anti-inflammatory properties (Kanitkar et al., 2008; Meng et al., 2013; Den
Hartogh et al., 2019). Curcumin has recently been reported to have a protective
effect on hepatocyte or neuronal cells prone to necroptosis (Dai et al., 2013;
Lu et al., 2016). Our study showed that curcumin had protective effects against
oxidative stress, inflammatory response, and fibrosis in high glucose-induced
podocyte injury, eventually improving podocyte function. These renoprotective
effects of curcumin might be associated with its ability to inhibit high
glucose-induced RIPK3 expression by inhibiting oxidative stress. Our
observations suggest that curcumin might be a potential therapeutic agent to
minimize the progression of podocytopathy caused by diabetes as an inhibitor of
RIPK3. Results indicate that curcumin treatment can protect against high
glucose-induced podocyte injuries by suppressing the abnormal expression of ROS
and RIPK3. Thus, curcumin might be a potential therapeutic agent for diabetic
nephropathy as an inhibitor of RIPK3.
Curcumin activates NLRC4, AIM2, and
IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript
factor in acute myeloid leukemia cell lines
Cancer Biology &
Therapy | June
2022
Curcumin, an active ingredient derived from turmeric, has been recognized
for its medicinal properties, including antioxidant, anti‐inflammation,
radical‐scavenging, anti-solid and -blood tumor, and so on. The anticancer
effects of curcumin mainly result from multiple biochemical mechanisms that are
involved in the regulation of programmed cell death, such as apoptosis,
autophagy. Recent studies have found that curcumin can induce pyroptosis of
solid tumor cells. Prior studies have shown that curcumin exert anti-cancer
effects by induction of apoptosis and autophagy. We have discovered that
curcumin can induce leukemia cell death by increasing apoptosis and pyroptosis
and that activated AIM2, IFI16, and NLRC4 inflammasomes play a key role in this
process. In addition, the anti-leukemia effect of curcumin is affected by the
expression of GSDMD. Thus, pyroptosis may be a potential new strategy for
treating leukemia, and GSDMD is a biomarker to evaluate curcumin sensitivity in
the leukemia therapy.
Effect of Curcumin on Apoptosis of Acute
T-Lymphoblastic Leukemia Cells
CNKI | June
2022
Curcumin can enhance the apoptosis of T-cell acute lymphoblastic leukemia
(T-ALL) cells induced by Mcl-1 small molecule inhibitor UMI-77 by reducing the
mitochondrial membrane potential, the mechanism may be related to the
inhibition of Notch1 signaling pathway.
Curcumin inhibits the
cancer‑associated fibroblast‑derived chemoresistance of gastric cancer
International Journal of Oncology | June
2022
Curcumin abrogated the CAF‑mediated activation of the JAK/STAT3 signaling
pathway in GC cells. In vivo data revealed the synergistic effects of curcumin
with 5‑FU treatment in xenograft GC tumors. These data strongly suggest that
the suppression of the JAK/STAT3 signaling pathway counteracts the CAF‑induced
chemoresistance of GC cells. It is suggested that curcumin may be a suitable
natural product which may be used to overcome chemoresistance by inhibiting the
CAF‑induced activation of the JAK/STAT3 signaling pathway in GC.
The effect
of curcumin supplementation on delayed-onset muscle soreness, inflammation,
muscle strength, and joint flexibility: A systematic review
Phytotherapy
Research | May
2022
Curcumin supplementation significantly reduced serum creatine kinase
activity, muscle soreness, and TNF-α concentration. Also, curcumin
supplementation elicited significant improvements in maximal voluntary
contraction (MVC) and range of motion (ROM). Curcumin supplementation may
improve some aspects of delayed-onset muscle soreness (DOMS), including muscle
damage, muscle soreness, inflammation, muscle strength, and joint flexibility.
Antiproliferative Effects of Curcumin Different Types of Breast Cancer
Journal of Cancer Prevention | May
2022
Breast cancer is one of the most frequently diagnosed malignancy among
women. Turmeric is isolated from Curcuma longa. Curcumin is main curcuminoid of
the turmeric which is a member of Zingiberaceae. In this current study
antiproliferative effects of curcumin were investigated in luminal A breast
cancer cell line MCF-7 and triple negative breast cancer cell line MDA-MB-231.
Curcumin, which has antiproliferative effects on breast cancer cells, is
thought to be effective in cancer treatment.
Effect of Curcumin on
Hippocampal Neurons, Learning, and Spatial Memory in a Model of Global Cerebral
Ischemia
Red Crescent Medical Journal | May
2022
Curcumin administration reduced spatial memory impairment in the treatment
group compared to the ischemia group. These results suggest that pretreatment
with curcumin can improve memory and learning disorders and hippocampal neuron
damage following ischemia.
Role of curcumin in ameliorating hypertension and
associated conditions: a mechanistic insight
Molecular and Cellular
Biochemistry | May
2022
Since ancient times, curcumin has been in use as food spices and folk
remedy to treat cough, cold, cuts and wounds, and skin diseases. Preclinical
and clinical studies have indicated that curcumin acts a promising therapeutic
agent in the management of a wide array of health issues, viz., hyperlipidemia,
metabolic syndrome, anxiety, arthritis, cancer and inflammatory diseases. Owing
to its enormous potential, recent research has been focused on the synthesis of
curcumin and its analogues for the management of metabolic disorders. In the
current scenario, hypertension is considered as a key risk factor due to its
involvement in various pathogeneses. Mechanistically, curcumin and its
analogues have been reported to elicit anti-hypertensive effect through diverse
signalling pathways.
The effects of curcumin as dietary supplement for
patients with COVID-19: A systematic review of randomized clinical trials.
Drug Discoveries & Therapeutics | May
2022
Accumulating evidence has been reported regarding the effect of curcumin as
a dietary antiviral on patients with COVID-19. Our review revealed that
curcumin might have a positive effect on relieving COVID-19 related
inflammatory response due to its powerful immune-modulatory effects on
cytokines production, T-cell responses, and gene expression. These findings
suggest that curcumin confers clinical benefits in patients with COVID-19.
Molecular Mechanism of Curcumin and Its Analogs as Multifunctional Compounds
against Pancreatic Cancer
Nutrition and Cancer | May
2022
Curcumin is a natural chemical substance obtained from plants with a wide
range of pharmacological activities. Research evidence suggests that curcumin
can influence PC development through multiple molecular mechanisms. This
review aims to summarize the mechanisms of action of curcumin in preclinical
and clinical studies on PC and research progress in enhancing its
bioavailability.
An Overview of Parkinson's Disease: Curcumin as a Possible
Alternative Treatment
Cureus | May
2022
Curcumin, turmeric's active ingredient, has antioxidant, anti-apoptotic,
and anti-inflammatory properties that protect tissues from the harmful effects
of reactive oxygen species (ROS). Curcumin's protective properties start
with its ability to cross the blood-brain barrier due to its lipophilic nature.
Curcumin has various protective properties in the brain, including protection
against toxic metals and ROS. Toxic metal ions can interfere improperly with
tissues in the brain, causing neurological damage. Curcumin, as a flavonoid,
has antioxidant properties that are potentially stronger than typical
antioxidants such as vitamins C and E. Curcumin also protects against A53T α-synuclein
aggregation and monoamine oxidase B, becoming a compound of interest in
treating neurodegenerative disorders such as Parkinson's disease. Curcumin has
been found to protect nigrostriatal dopaminergic neurons from damage in animal
models. Curcumin had protective effects on alpha7-nicotinic acetylcholine
receptors after administration of 6-hydroxydopamine (6-OHDA) in rats with a
curcumin dose of 200 mg/kg. Curcumin restored nigrostriatal dopamine neurons to
87.3% and 84.8%. Curcumin's ability to donate an H ion from the beta-diketone
moiety is thought to be responsible for its anti-ROS properties. Curcumin
protects mitochondria and neurons from the damaging effects of ROS by donating
an H ion. Curcumin's powerful antioxidant capabilities, including chelation of
harmful metals and lowering ROS, may help reduce inflammation and apoptosis.
Because neurons are terminal tissues, reducing ROS may improve their longevity
and the efficacy of pharmaceutical therapies. These findings imply that
curcumin could be used in conjunction with standard Parkinson's disease
medication to improve treatment and results.
Antitumor Properties of
Curcumin in Breast Cancer Based on Preclinical Studies: A Systematic Review
Cancers | May
2022
Studies have shown that curcumin administered at different concentrations
inhibited proliferation, decreased viability, and induced apoptosis in human
and animal breast cancer cells. This review assesses the antitumor
effects of curcumin on breast cancer reported in preclinical in vitro and in
vivo animal models. We used five databases to search for preclinical studies
published up to May 2021. The assessments included the effects of curcumin on
the proliferation, viability, and apoptosis of breast cancer cell lineages and
on tumor volume. In total, 60 articles met the inclusion criteria. Curcumin
administered at different concentrations and via different routes of
administration inhibited proliferation, decreased viability, and induced
apoptosis in human and animal breast cancer cells.
Docking Analysis of Some
Bioactive Compounds from Traditional Plants against SARS-CoV-2
Molecules
|
May
2022
Curcumin and its analogues are the main phytonutrients of turmeric (Curcuma
longa L.) which is widely used around the world as culinary spices,
traditional medicine as well as a popular dietary supplement ingredient due to
its wide range of health benefits including anti-inflammation, anti-cancer,
cardiovascular regulation, respiratory, and immune system benefits. In
addition, the suppression of multiple cytokines by curcumin suggested that it
may be a useful approach in treating curcumin, and demothoxycurcumin exhibited
high binding affinity on SARS-CoV-2 S- protein, PLpro, and RdRp. Binding of
these proteins interfere with the viral entry, replication, and immune response
evasion. Therefore, these compounds may have a great potential for inhibiting
the virus.
Curcumin and Thymoquinone Combination Attenuates Breast Cancer
Cell Lines’ Progression
Integrative Cancer Therapies | May
2022
Curcumin, the active ingredient of Curcuma longa, is the most studied
compound described as a potential anticancer agent. Curcumin targets
multiple signaling/molecular pathways including, Rb, p53, mitogen-activated
protein kinase, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT),
and nuclear factor kappa B cells (NF-κB). Previous studies have demonstrated
that curcumin can inhibit cancer cell proliferation. Recently, curcumin was
reported to suppress breast cancer cell proliferation and migration through
autophagy-dependent AKT degradation and increased natural killer cells
activity. Curcumin, TQ, and their combination induced significant apoptosis of
both cells and hindered their progression. Several reports have shown the
anticancer effect of either curcumin or TQ against MCF7 and MDA-MB-231
cell lines. One interesting finding is curcumin , TQ, and their
combination had synergistic effects. Curcumin decreased proliferation and
colony formation activities in MCF7 and MDA-MB-231 cell lines. This study
supports evidence from previous observations of Effenberger-Neidnicht and
Schobert,31 Attoub et al,32 Masuelli et al,33 Zhou et al,34 and El-Far et al16
who reported significant increases in caspase-3 expression, protein levels, or
activities in either MCF7 or MDA-MB-231 cell lines treated with curcumin. These
results suggest the promising anticancer benefit of the curcumin and TQ
combination against breast cancer.
Curcumin Inhibits the Growth and
Metastasis of Melanoma via miR-222-3p/SOX10/Notch Axis
Disease
Markers | May
2022
Due to its antiinflammatory and antioxidant properties, curcumin has been
also reported to have significant health benefits, including improved brain
function and anticancer/anti-therosclerotic properties. A previous study has
been indicated that curcumin could inhibit breast cancer cells proliferation
and invasion via repressing the NF-κB inducing genes. It has been suggested
that curcumin could influence the G0/G1 phase arrest by MTA1-
(metastasis-associated protein 1-) induced inactivation of Wnt/β-catenin
pathway in the lung cancer cell. In gastric cancer, curcumin could induce MMP
proteins dissipation and cytochrome C into the cytosol in SGC-7901 cell lines,
resulting in the downregulation of migration ability and apoptosis escaping. In
colon cancer HCT116 and HT29 cells, curcumin could inhibit the level and
activity of hexokinase II (HKII) by a concentration-dependent manner, inducing
cell apoptosis. There is also an increasing number of studies showing that
curcumin can also induce apoptosis and inhibit proliferation of melanoma cancer
cells. In summary, these results indicated that curcumin was a key role in
impeding the proliferation, migration, and invasion ability of melanoma cells.
Curcumin could inhibit the proliferation, migration, and invasion of melanoma
cells. Furthermore, curcumin repress the expression of SOX10, Notch1, and
HES-1, and increase the expression of miR-222-3p. In addition, inhibition of
miR-222-3p expression reversed the inhibitory effect of curcumin the growth of
melanoma cells. Curcumin enhances the miR-222-3p level to reduce SOX10
expression, and ultimately inactivates the Notch pathway in repressing melanoma
proliferation, migration, and invasion. According to the above, curcumin
represents a potential therapeutic agent for the treatment of melanoma.
Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC)
Omicron
Computers in Biology and Medicine | May
2022
Curcumin, among seven phytochemicals, was found to have the most
substantial inhibitory potential with Omicron S protein. Further, it was found
that curcumin could disrupt the Omicron S-hACE2 complex. The molecular dynamic
simulation demonstrated that Curcumin could form a stable structure with
Omicron S in the physiological environment. Conclusion To conclude, Curcumin
can be considered as a potential therapeutic agent against the highly
infectious Omicron variant of SARS-CoV-2.
Curcumin supplementation may
improve metabolic, inflammatory, and obesity markers in women with rheumatoid
arthritis.
Clinical Edge Journal Scan | May
2022
Curcumin consumption for 8 weeks as a part of an integrated approach could
help modulate metabolic factors, inflammation, and adiposity in women with
rheumatoid arthritis. Major finding: After 8 weeks, insulin resistance,
erythrocyte sedimentation rate, serum levels of high-sensitivity C-reactive
protein, and triglycerides improved significantly in the curcumin
supplementation vs. placebo group. Moreover, curcumin supplementation
significantly decreased mean weight, body mass index, and waist circumference
vs. no significant changes observed in placebo group.
Curcumin can improve
Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways
Food
and
Chemical Toxicology | May
2022
Curcumin, as one of the natural polyphenols, is significant in stimulating
PI3k/Akt/glycogen synthase kinase 3 (GSK3) and BDNF/tyrosine kinase receptor B
(TrkB)/PI3k/Akt signaling pathways, has great potential in neurodegenerative
diseases and other different pathological settings. Curcumin can delay the
progression of Parkinson's disease by protecting nerve cells.
The potential
of curcumin for treating spinal cord injury: a meta-analysis study
Nutritional Neuroscience | May
2022
Curcumin had a strong significance in improving functional recovery after
spinal cord injury. When curcumin was administered daily, it had a stronger
effect than single-dose treatment or weekly administration. Curcumin also
significantly reduced the expression of GFAP (Glial fibrillary acidic protein)
marker compared to untreated groups. These findings suggest that daily
administration of curcumin can be an effective approach to improving functional
recovery after spinal cord injury.
Therapeutic role of curcumin in adult
neurogenesis for management of psychiatric and neurological disorders: a
scientometric study to an in-depth review
Critical Reviews in Food
Science
and Nutrition | May
2022
Curcumin is a primary constituent of curcuminoid that exerts several
positive pharmacological effects on aberrant neurogenesis. We explore the
mechanisms by which curcumin regulates adult neurogenesis and in turn affects
psychiatric diseases, i.e., depression and neurological disorders among them
traumatic brain injury (TBI), stroke, Alzheimer’s disease (AD), Gulf War
Illness (GWI) and Fragile X syndrome (FXS). This review aims to elucidate the
therapeutic effects and mechanisms of curcumin on adult neurogenesis in various
psychiatric and neurological disorders. Specifically, we discuss the regulatory
role of curcumin in different activities of neural stem cells (NSCs), including
proliferation, differentiation, and migration of NSCs. This is geared toward
providing novel application prospects of curcumin in treating psychiatric and
neurological disorders by regulating adult neurogenesis.
The Impact of
Curcumin on the Inflammatory Profile of SW982 Cells in a Rheumatoid Arthritis
Model
Journal of Immunology Research | May
2022
Curcumin, a natural polyphenol extracted from Curcuma longa, possesses
plenty of proven properties, beneficial in ameliorating autoimmunological
diseases, such as rheumatoid arthritis. Due to its structure, curcumin is a
free radical scavenger, reducing redox-related inflammatory signaling.
Profitable attributes of curcumin have been shown to lay a heavy impact on the
functionality of rheumatoid arthritis by reducing their survivability and hence
the number of overproliferating cells, decreasing expression of IL-1β, TNF-α,
and COX-2 proteins and diminishing production of tissue destroying
metalloproteinases. Presented anti-inflammatory properties, safety, and low
cost of usage make curcumin a great candidate for potential therapies, which
are already tested in trials conducted on patients with Rheumatoid arthritis.
Aside from proving the overall anti-inflammatory properties of curcumin,
results of conducted experiments showed some of the molecular basics of its
action. Conducted investigations indicate the promising role of curcumin in
decreasing the inflammation, enhancing its position as the potential compound
in potential rreumatoid arthritis therapies.
Therapeutic Effects of Curcumin
on Osteoarthritis and Its Protection of Chondrocytes
Alternative
Therapies
in Health and Medicine | May
2022
The curcumin group show higher improvements in safety, joint
mobility, and inhibition of inflammation. In-vitro experiments showed that
curcumin inhibited the apoptosis rate of chondrocytes and the levels of
inflammatory factors, while the Wnt/β-catenin inhibitor did the opposite.
Curcumin can effectively decrease the pathological results of OA, with a
remarkable safety profile; its mechanism may be the activation of the
Wnt/β-catenin signaling pathway to inhibit the inflammatory reaction and
apoptosis in chondrocytes.
Curcumin treats endometriosis in mice by the HIF
signaling pathway
American Journal of Translational Research | May
2022
Curcumin has become a hot topic in medical research because of its various
pharmacological activities, such as anti-inflammatory and antioxidant. Curcumin
has therapeutic effects on a variety of human diseases, including cancer,
cardiovascular disease, diabetes, arthritis, neurologic disorders, Crohn’s
disease, and cardiovascular disease. The modulation of curcumin for tumors has
received the most attention from researchers; approximately 37% of curcumin
studies are related to tumors. Curcumin can modulate multiple cellular
signaling pathways simultaneously to alleviate or prevent different types of
cancer, including multiple myeloma, colorectal, pancreatic, breast, prostate,
and lung cancers, because it can modulate growth factors, enzymes,
transcription factors, kinases, inflammatory cytokines, and apoptotic proteins.
Previous studies focused on the antioxidant stress capacity of curcumin, which
reduced ROS directly by enhancing the intracellular levels of reduced
glutathione and counteracted antioxidants by increasing the activity of
antioxidant enzymes and activating the Nrf2-Keap1 pathway. Our study
demonstrated for the first time that curcumin can treat endometriosis and
improve disease hypoxia through the HIF-1α pathway. Consistent with previous
studies, curcumin exhibited therapeutic effect on endometriosis by inhibiting
oxidative stress, thus alleviating inflammation. The real situation may be that
curcumin inhibits oxidative stress on the one hand and improves hypoxia on the
other hand. The number of lesions, volume, and degree of adhesions were
significantly reduced in the curcumin group compared to the negative control
group and the control group. Curcumin played a role in the treatment of
endometriosis by modulating the HIF signaling pathway, improving the local
hypoxia of the lesion, and reducing the inflammatory state of endometriosis.
Curcumin: A therapeutic strategy for targeting the Helicobacter pylori-related
diseases
Microbial Pathogenesis | May
2022
Curcumin exhibits anti-inflammatory, anti-carcinogenic, anti-oxidant
properties and is widely used as a natural product-derived medicine or
nutraceutical. Furthermore, curcumin has been reported to have anti-bacterial
activity. Therefore, curcumin might be an effective herbal-based medicine for
preventing, managing, or treating H. pylori infection. This review discusses
the anti-inflammatory, anti-cancer, and anti-bacterial properties of curcumin
as it pertains to gastric cancer and H. pylori-associated diseases.
Curcumin
Selectively Induces Colon Cancer Cell Apoptosis and S Cell Cycle Arrest by
Regulates Rb/E2F/p53 Pathway
Journal of Molecular Structure | May
2022
Curcumin has anti-inflammatory and anti-tumor activity. Curcumin
induces cells apoptosis through p53-mediated mechanism. Curcumin destabilizes
cell cycle distributions by Rb/CDK/E2F signaling pathway. Curcumin inhibits
tumor growth in vivo. Our data showed that curcumin preferentially and, in a
dose, dependent way inhibited colon cancer cells proliferation, but was not
toxic to normal colon mucosa epithelial cells. Curcumin induced apoptosis
through a p53-mediated mechanism. Curcumin may be a potential strategy for the
treatment of colon cancer.
The effect of curcumin on the risk of mortality
in patients with COVID-19: A systematic review and meta-analysis of randomized
trials
Phytotherapy Research | April
2022
Curcumin is a natural polyphenolic compound with multiple benefits,
including antiviral, anti-inflammatory, anticoagulant, antiplatelet, and
cytoprotective, which have been demonstrated to be advantageous in reducing the
progression of several inflammatory illnesses (Rattis, Ramos, & Celes, 2021).
The aforementioned effects have made curcumin one of the potential treatment
options for patients with COVID-19. Since the pathophysiology of COVID-19 is
known to involve life-threatening inflammatory reactions, cytokine storms, and
coagulopathy, curcumin can be advantageous due to its anti-inflammatory effects
via the inhibition of inflammasome formation (Yin et al., 2018). In addition,
curcumin also demonstrates antiviral effects via its ability to bind to the
viral primary protease (Mpro) enzyme of SARS-CoV-2, which is required for viral
replication. Curcumin also prevents viral attachment and passage into the host
cell with great potency (Dourado et al., 2021). The ability of curcumin in
inhibiting the virus-receptor interaction is in two ways, according to modeling
studies: it inhibits both the spike protein and the ACE2 receptor (Manoharan et
al., 2020). Previously in this journal, the findings of the randomized trial
reported by Hassaniazad et al. (2021) suggest that curcumin can accelerate the
recovery of acute inflammatory phase in patients with COVID-19 by modulating
inflammatory immune responses.
Curcumin as a Potential Therapeutic Agent in
Certain Cancer Types
Cureus | April
2022
Curcumin has no noticeable toxicity and, in combination with existing
chemotherapeutic agents, is a superior treatment option for certain cancer
types. The potential applications of curcumin include the prevention and
treatment of cancer, anti-inflammatory/antioxidant, and antiangiogenic
activities. These beneficial effects of curcumin are exerted by modulating
signaling molecules, including cytokines, chemokines, transcription factors,
adhesion molecules, microRNAs, tumor suppressor genes, etc.. Several studies
have shown the antitumor activity of curcumin on breast cancer, prostate
cancer, brain cancer, lung cancer, and pancreatic cancer. Curcumin is a potent
anti-oxidative, anti-inflammatory, and anti-tumor agent, and it is extracted
from rhizomes of Curcuma species. Curcumin, as a cancer treatment agent, is
recognized to affect multiple targets in different stages of cancer, including
angiogenesis, proliferation, metastasis, and apoptosis. The molecular mechanism
of action of curcumin has been studied comprehensively. It exerts this effect
by interfering with several cell-signaling pathways as well as inducing and
inhibiting the production of various growth factors, enzymes, or cytokines. Its
therapeutic effects for the breast, lung, prostate, intestinal, liver, and
hematological malignancies have been proven in the pre-clinical as well as in
vivo studies.
Effects of Curcumin on Inflammatory Response During
Exercise-Induced Muscle Damage
Biointerface Research in Applied
Chemistry |
April
2022
The results of this study explain that curcumin was able to provide anti-
inflammatory effects by reducing pro-inflammatory cytokines such as IL-6, IL-8,
TNF-α. Curcumin can also reduce muscle pain intensity, decrease CK activity,
and increase ROM. The curcumin dose showed to reduce various inflammatory
responses due to EIMD. Therefore, it is recommended that curcumin be used in
individuals who carry out physical activities, leading to muscle damage and
inflammation. Curcumin's anti-inflammatory benefits have been well known.
Curcumin works by altering COX-2 pathway signaling, resulting in decreased
pro-inflammatory cytokine and prostaglandin production. Curcumin is able to
provide anti-inflammatory effects by reducing pro-inflammatory cytokines such
as IL-6, IL-8, TNF-a. Curcumin can also reduce muscle pain intensity, decrease
CK activity, and increase ROM. We recommend that curcumin be used in
individuals who engage in physical activity that results in muscle damage and
inflammation.
Specific Metabolic Response of Patient-derived Organoids to
Curcumin of Colorectal Cancer
Journal of Chromatography | April
2022
Curcumin has been found to be effective in suppressing various phases of
colorectal cancer development. Our research provided a reference for further
revealing the role of curcumin in human-derived colorectal cancer-like solid
tumors.
Quality of Evidence Supporting the Role of Curcuma Longa
Extract/Curcumin for the Treatment of Osteoarthritis: An Overview of Systematic
Reviews
Evidence-Based Complementary and Alternative Medicine |
April
2022
Recently, curcuma longa extract, an anti-inflammatory and antioxidant
preparation) has been used in traditional Chinese medicine and Ayurveda to
treat arthritis and has thus become an attractive treatment option for
improving the joint condition of OA patients. Often used as an alternative
medicine or dietary supplement, turmeric is typically an extract that is
standardized to 80–95% curcuminoids, among which curcumin is the most active
ingredient in turmeric and is “generally regarded as safe” by the US FDA. In
addition, the curcumin alone has anti-inflammatory properties similar to
NSAIDs. Well known for its good anti-inflammatory effect, curcuma longa extract
has a potential effect on osteoarthritis, and a large number of researchers
have completed several systematic reviews/meta-analyses in this research area.
According to the available published evidence, curcumin may be effective and
safe for the treatment of osteoarthritis.
Curcumin for
attention-deficit–hyperactivity disorder (ADHD) a systematic review and
preliminary behavioral investigation
Naunyn-Schmiedeberg's Archives
of
Pharmacology | April
2022
Curcumin has protective actions in neuropsychiatric disorders, acting as a
neuroprotective agent. As a first approach, the study aimed at a systematic
review of the potential effects of curcumin on cognitive performance for
attention-deficit–hyperactivity disorder (ADHD). The results of the Y-Maze Test
demonstrated that curcumin improved spatial memory.
Protective Effects of
Curcumin-Regulated Intestinal Epithelial Autophagy on Inflammatory Bowel
Disease in Mice
Gastroenterology Research and Practice | April
2022
This study was aimed at exploring the ameliorating effect of curcumin on
inflammatory bowel disease (IBD) in mice induced by 3% dextran sodium sulfate
(DSS) by regulating intestinal epithelial cell autophagy. Compared with that of
the DSS group, the diet of mice in the curcumin group was improved, the decline
of body weight was slowed down, the hair glossiness was restored, the blood in
the stool gradually decreased or occulted, the DAI score was decreased, the
colon tissue was significantly improved, the expressions of LC3-II/LC3-I and
Beclin1 were significantly increased, and the p62 was significantly decreased.
Therefore, curcumin can increase the expression level of autophagy protein in
IBD mice, which may be one of the molecular mechanisms for the treatment of IBD
intestinal inflammation.
Anticancer Properties of Curcumin Against
Colorectal Cancer: A Review
Frontiers in Oncology | April
2022
Several studies show that curcumin belongs to a class of plant-derived
chemicals that can help prevent colorectal cancer. Several possible pathways
have been proven in both in vitro and in vivo animal studies. Furthermore,
treatment improvements in animals with inflammatory and hereditary colorectal
cancer have been discovered. The Curcuma longa roots (dried) plant are used to
produce curcumin. It has been discovered to have anti-carcinogenic properties.
Curcumin has the ability to target colon cancer cells specifically, while
allowing normal cells to remain alone; cancerous cells die as a result of an
elevation in the expression of a protein known as GADD45a (Gene activated
during DNA damage). Studies in humans have shown the ability of curcumin to
tilt the ratio of pathogenic microbes and beneficial microbes. Curcumin, in
fact, may lower intestinal inflammation via regulating gut flora. Curcumin was
showed to reduce NF-κB activation in colonic epithelial cells and increase the
growth of CD4+ Foxp3+ regulatory T cells in the colonic mucosa in an
experimental DSS-colitis model. Another study revealed the effect of curcumin
consumed in diet could cause an increase in the species of Clostridium,
Enterobacter (have the potential to enhance mucosal Treg cells by producing
butyrate) and reducing the levels of Blautia and Ruminococcus species (which
has been linked with individuals that has colorectal cancer) that is present in
abundance
The Curcumin Supplementation with Piperine Can Influence the
Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
Biology | April
2022
The most important findings of this study were the administration of
curcumin associated with piperine can inhibit the elevation of plasmatic levels
of some cytokines such as IL-2, TNF-α, IFN, IL-6, and IL-10. This result shows
the capacity of curcumin to modulate an inflammatory response acutely induced
by exercise. Supplementation with 500 mg of curcumin associated with 20 mg of
piperine for seven days was able to inhibit the inflammatory response after an
experimental protocol of running on a treadmill until voluntary fatigue.
The
Golden Spice Curcumin in Cancer: A Perspective on Finalized Clinical Trials
During the Last 10 Years
Journal of Cancer Research and Therapeutics
| April
2022
Curcumin is the main curcuminoid in turmeric and has been found to possess
various beneficial properties, including anti-inflammatory, antioxidant,
neuroprotective,, chemopreventive, and chemotherapeutic, activities, which make
this phytocompound famous. Curcumin affects multiple signaling pathways
involved in cell proliferation, survival, cell death, angiogenesis, invasion,
migration, and metastasis. Cancer preventive and anticancer therapeutic actions
of curcumin against different types of cancers, such as breast, liver,
melanoma, lung, and endometrium, are available in the literature. Based on
clinical trials in cancer patients, it was concluded that even 8 g of curcumin
was safe and well tolerated. As a therapeutic agent, curcumin has been
subjected to clinical trials for various diseases, such as psoriasis, multiple
myeloma, chronic uveitis, pancreatitis, pancreatic, colorectal, and biliary
tract cancers, familial adenomatous polyposis, inflammatory bowel disorder,
Alzheimer's disease, and diabetes mellitus. Various clinical trials
investigated curcumin's bioavailability, its effect on various cancer types,
and the efficacy of turmeric and curcumin in mitigating the side effects of
cancer chemotherapy and radiotherapy. We have presented 21 clinical trials, 16
of the 21 clinical trials were associated with the effectiveness of curcumin on
various types of cancer, and the other 5 clinical trials were related to
the evaluation of the curcumin's efficacy in relieving the side effects of
cancer chemotherapy and radiotherapy. The emerging data from clinical trials
confirm that curcumin has considerable potential to treat cancer patients. It
is expected that findings from ongoing and future clinical trials may help the
clinical application of curcumin in managing different types of cancer.
A
Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in
Relation to its Major Active Constituent Curcumin
Frontiers in
Pharmacology
| April
2022
Curcumin has a variety of beneficial effects on humans, according to
science. Curcumin’s efficacy, safety, and pharmacokinetics have all been
examined extensively in clinical studies over the last 50 years (Gupta et al.,
2013; Subramani et al., 2018). Cancer, CVD, arthritis, atherosclerosis,
diabetes, gastric illness, IBD, psoriasis, acquired immunodeficiency syndrome,
and other inflammatory disorders are all examples of pleiotropic activities.
Several studies in this review discovered the anti-inflammatory effects of
curcumin, including decreased white blood cell, neutrophil, and eosinophil
numbers, as well as protective effects on serum levels of inflammatory
mediators like phospholipase A2 and total protein in various inflammatory
disorders. Curcumin has anticancer properties by interfering with many cellular
systems and inhibiting/inducing the production of multiple cytokines, enzymes,
or IκKβ, TNF-α, STAT3, COX-2, PKD1, NF-κB, epidermal growth factor, and MAPK,
among others. Under oxidative stress conditions, curcumin decreased MDA
and NO levels while increasing thiol, SOD, and catalase levels. Curcumin also
influenced the lifespan of organisms by regulating important signaling pathways
such as the mTOR, PKA, and FOXO signaling pathways. In conditions where the
immune system was disturbed, treatment with C. longa and curcumin enhanced IgE,
IL-4, TGF-β, IL-17, IFN-γ, and the Th1/Th2 ratio. The pharmacological effects
of curcumin on respiratory, allergy, and immunologic problems suggest that
curcumin may have a possible therapeutic effect on these illnesses. Curcumin
delay the onset of diabetes, improve β-cell functioning, prevent β-cell death,
and reduce insulin resistance in animal models.Traditional medicine has
exploited dried curcumin powder to treat illnesses in history. C. longa is said
to have antitoxic, anticancer, antibacterial, anti-inflammatory, and
antioxidant effects (Ghotaslou et al., 2017). Rhizome powder is supposed to
flavor various cuisines and treat numerous disorders, including inflammation,
flatulence, jaundice, menstrual troubles, hematuria, and hemorrhage. It is also
a useful ointment to treat several skin disorders. Curcumin or
diferuloylmethane and numerous volatile oils. C. longa of India is particularly
popular when compared with those from other countries due to its high curcumin
concentration, which is the most essential and active biological ingredient
responsible for its therapeutic potential (Verma et al., 2018). Curcumin shows
antioxidant features close to vitamins C and E in both aqueous and fat-soluble
extracts.
Effects of turmeric (Curcuma longa) and its constituent
(curcumin) on the metabolic syndrome: An updated review
Journal of
Integrative Medicine | April
2022
Based on studies, turmeric and its bioactive component, curcumin, due to
their anti-inflammatory and antioxidant properties, have antidiabetic effects
through increasing insulin release, antihyperlipidemic effects by increasing
fatty acid uptake, anti-obesity effects by decreasing lipogenesis, and
antihypertensive effects by increasing nitric oxide. According to several in
vivo, in vitro and human studies, it can be concluded that turmeric or curcumin
has important values as a complementary therapy in Metabolic syndrome. In vitro
and in vivo studies have proved that curcumin has anticancer,
anti-inflammatory, antioxidant and anti-fat properties. Some studies have shown
that curcumin has protective effects against many chronic diseases, for
example, autoimmune disorders and pulmonary diseases. It has cardioprotective
effects due to its lipid-lowering properties. In the last few years, much
consideration has been paid to the benefits of curcumin. It can inhibit the
development of atherosclerosis and also significantly reduce the serum levels
of triglyceride (TG) and low-density lipoprotein-cholesterol (LDL-C). Also,
curcumin can increase insulin sensitivity through the inhibition of protein
tyrosine phosphatase 1B. It has antioxidant effects in the artery and also can
decrease the levels of reactive oxygen species (ROS) in the basilar artery
wall. It remarkably delayed the onset of stroke. Curcumin in diabetic
conditions decreased the levels of fast blood sugar, uric acid, serum urea and
creatinine. Curcumin significantly alleviated the severity of liver fibrosis.
Curcumin treatment lowered the increased blood pressure. It also plays a
significant role in obesity and significantly decreases adiposity. One of
curcumin and turmeric anti-diabetic mechanisms is decreasing the
phosphorylation level of insulin and inhibiting the activation of the NF-κB.
Curcumin and turmeric can treat hypertension by suppressing downregulation of
eNOS.
Evaluation of the Anti-Cancer Effect of Curcumin on MCF-7 Cells in 3D
Culture Conditions to Increase the Efficacy of Breast Cancer Treatment
Journal of Applied Biotechnology Reports | April
2022
Curcumin reduces the production of cellular NO and increases the production
of catalase and glutathione, which confirms the results of the NO test. In
addition, the release of cytochrome c from Mitochondria from cells treated with
different concentrations of curcumin compared to control cells are significant.
The evaluation of the toxicity effect of curcumin at concentrations of 20, 40,
and 80 μM using comet assay showed that this substance induces apoptosis in
MCF-7 cells in a dose-dependent manner. The findings of this study showed that
the anti-cancer effect of curcumin on MCF-7 cells under 3D culture conditions
could increase the effectiveness of treatment. The cancer cell survival rate
actually depended on curcumin concentration.
Curcumin Alleviates
DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis
Oxidative Medicine and Cellular Longevity | April
2022
Curcumin is a yellow polyphenol extracted from the rhizome of the ginger
plant, which has been shown to have effects against both depression and
anxiety. Research has indicated that curcumin affects the gut microbiome and
exerts antianxiety and neuroprotective effects through the microbiota-gut-brain
axis. The results suggested that curcumin can effectively relieve anxiety-like
behaviors caused by DSS in mice. Further, curcumin treatment can alleviate
disturbances in the gut microbiota and systemic disorders of lipid metabolism
caused by DSS. Finally, through FMT, we verified that curcumin increased
phosphatidylcholine in the prefrontal cortex of the mice and alleviated
DSS-induced anxiety-like behaviors by modulating specific gut microbiota. We
also revealed that Muribaculaceae may be a key part of the gut microbiota for
curcumin to alleviate DSS-induced anxiety-like behaviors through the MGB axis.
Curcumin is also believed to hold medicinal properties against many diseases,
including gastrointestinal, cardiovascular, and mental diseases. High
concentrations of curcumin have been detected in the gastrointestinal tract
after oral administration. Supplementation of curcumin significantly enriched
beneficial bacteria such as Butyricicoccus, a butyrate producing genus in the
intestinal tract, and reduced Ruminococcus, and Mucispirillum, which were
implicated in the development of obesity and diabetes. These findings were the
basis to suggest that curcumin directly affects the gut microbiome despite its
low systemic bioavailability. Curcumin can relieve inflammation and digestive
tract symptoms caused by IBD.
Curcumin induces cortico-hippocampal neuronal
reshaping and memory improvements in aged mice
Journal of Chemical
Neuroanatomy | April
2022
Traditional medicine has long benefitted from naturally occurring molecules
such as curcumin (diferuloymethane). Curcumin is extracted from the plant
Curcuma longa and is known for its synaptic and antioxidant-related benefits.
In this study, we tested the hypothesis that chronic curcumin treatment reduces
cognitive and cellular effects of aging. Curcumin-treated mice showed improved
learning and memory using the Morris Water Maze and novel object recognition
task. In addition, using the Golgi-Cox stain, curcumin treatment increased
spine density in all evaluated regions and increased dendritic arborization in
the prefrontal cortex (PFC) layer 3 and CA3 subregion of the hippocampus.
Moreover, chronic curcumin exposure increased synaptophysin and actin
expression and reduced glial fibrillary acidic protein expression, a marker of
astrocytes, in the hippocampus (CA1 and CA3 subregions), while simultaneously
reducing the ROS-related molecule, metallothionein 3 expression in the PFC and
hippocampus. Collectively, these novel findings suggest that curcumin reduces
cognitive, neuronal and astrocytic signs of aging in mice. Curcumin is the main
metabolite found in Curcuma longa with potential benefits in aging.
Curcumin-treated mice showed improved learning and memory in aged mice.
Curcumin treatment increased dendritic arborization in the PFC and hippocampus.
Curcumin exposure reduced astrocytic expression in the hippocampus.
Curcumin
as a Potential Therapeutic Agent in Certain Cancer Types
Cureus
Journal of
Medical Science | March
2022
Several anticancer compounds have been extracted from plant sources such as
Curcuma longa. Among these, curcumin (diferuloylmethane) has no noticeable
toxicity and, in combination with existing chemotherapeutic agents, is a
superior treatment option for certain cancer types. Curcumin is an important
component of the curcuminoids family and is isolated from the rhizome of
Curcuma longa L. (turmeric). The potential applications of curcumin include the
prevention and treatment of cancer, anti-inflammatory/antioxidant, and
antiangiogenic activities. These beneficial effects of curcumin are exerted by
modulating signaling molecules, including cytokines, chemokines, transcription
factors, adhesion molecules, microRNAs, tumor suppressor genes, etc. Several
studies have shown the antitumor activity of curcumin on breast cancer,
prostate cancer, brain cancer, lung cancer, and pancreatic cancer. Curcumin is
a potent anti-oxidative, anti-inflammatory, and anti-tumor agent, and it is
extracted from rhizomes of Curcuma species. Curcumin, as a cancer treatment
agent, is recognized to affect multiple targets in different stages of cancer,
including angiogenesis, proliferation, metastasis, and apoptosis. The molecular
mechanism of action of curcumin has been studied comprehensively. It exerts
this effect by interfering with several cell-signaling pathways as well as
inducing and inhibiting the production of various growth factors, enzymes, or
cytokines. Structural and chemical modifications have been tried to enhance the
selectivity, bioavailability, and efficacy of curcumin for cancer. Its
therapeutic effects for the breast, lung, prostate, intestinal, liver, and
hematological malignancies have been proven in the pre-clinical as well as in
vivo studies.
An Update on the Exploratory Use of Curcumin in
Neuropsychiatric Disorders
Antioxidants | March
2022
Curcumin, the active compound of turmeric, is a polyphenol that has also
been largely used as a remedy for different pathologies in Asia for several
decades due to its healthy and biopharmacological properties, and its lack of
adverse effects, even at high doses. Moreover, curcumin has been reported to
have anti-inflammatory, antioxidant, neuroprotective, and even anti-aging and
antineoplasic properties. Curcumin may exert its anti-inflammatory and
antioxidant (anti-IOS) effects by influencing the synthesis of some IOS
regulators, such as heme-oxygenase-1 (HO1), glutathione (GSH), catalase (CAT),
and superoxide dismutase. These properties cause curcumin to have an impact on
those diseases in which IOS regulation does not work correctly and are related
to the disease appearance. Thus, curcumin may exert a beneficial effect on the
immune system, reducing B lymphocyte proliferation by inhibiting B lymphocyte
stimulator (BLYS). Curcumin can also reduce the neutrophil recruitment to areas
affected by inflammation, and can also increase the phagocytic activity of
macrophages. Furthermore, curcumin has proven to be an effective modulator of
the endocrine system, enhancing the uptake or regulating some hormones, such as
insulin. All these properties have boosted the interest of researchers in this
compound in recent decades. Recently, curcumin has also been used in
different psychiatric disorders due to the likely involvement of IOS processes
in their onset and evolution. In this sense, the above-described role of
curcumin as an anti-IOS drug made this compound a good candidate to halt or
palliate the course of these diseases. Anti-inflammatory, antioxidant, and
neuroprotective properties of curcumin, along with many multi-target beneficial
effects, such as the modulation of monoamine synthesis, have exponentially
promoted the investigation of its properties during this last decade.
Two-hundred and ninty-six articles containing research on curcumin were
published in the PubMed database in 2005. In 2010, this number increased to 714
and, in 2020, to 2130. A total of 65 preclinical studies and 14 clinical trials
were reported. Most of these studies were conducted on depression,
approximately 88% were preclinical studies and 64% were clinical studies. In
all disorders, curcumin was well tolerated, with no harmful side effects. This
was not surprising, as curcumin has been used for the last centuries as an
additive spice in East Asian cuisine. Moreover, curcumin was shown to be
beneficial in palliating or reversing symptoms associated with psychiatry in
all the studies analyzed and completed. In clinical trials, curcumin proved to
be effective in alleviating both positive and negative symptoms of
schizophrenia when administered together with regular antipsychotic medication.
The clinical relevance of these results could be of great importance, due to
the adverse events that can be caused by the extensive and chronic use of
antipsychotics. In this sense, curcumin could exert its beneficial effect in
schizophrenia through an inhibition of PLA2 enzyme. In depression, we found the
vast majority of studies, in both preclinical and clinical domains, showed some
beneficial effect of curcumin in reducing symptoms associated with depression.
In addition to the recognized role of curcumin as an anti-inflammatory and
antioxidant agent, positive improvement of depressive deficits could be exerted
through modulation of the indolamine 2,3-dioxygenase (IDO) enzyme. Therefore,
the overall effect of curcumin in this disorder seems to be mainly positive.
Overall, curcumin, due to its anti-inflammatory and antioxidant properties, has
been shown to be effective in the vast majority of the studies presented.
Curcumin-Rich Curry Consumption and Neurocognitive Function from 4.5-Year
Follow-Up of Community-Dwelling Older Adults
Nutrients | March
2022
Curcumin is a polyphenolic compound isolated from the roots of Curcuma
longa, from which turmeric is prepared and used widely as a coloring agent,
food additive and traditional Indian and Chinese medicine. For decades,
curcumin and related bioactive curcuminoids (demethoxycurcumin and
bisdemethoxycurcumin) have been the center of interest of scientific studies
worldwide into their therapeutic potentials. Numerous laboratory studies have
documented its antioxidant, anti-inflammatory, antimicrobial, antiviral,
antineoplastic and antiaging activities. Curcumin is actively being
investigated for its potential neuroprotective benefits. In vitro and in vivo
studies show that curcumin crosses the blood–brain barrier and can bind to β
amyloid (Aβ) and tau-inhibiting Aβ aggregation and modulate tau processing.
Animal studies show that curcumin decreases Aβ deposition and plaque load in
the brain of transgenic mouse models of AD. Experimental studies have also
demonstrated that curcumin possesses beneficial antiplatelet, antidiabetic and
cardioprotective activities ameliorating cardiac hypertrophy and chronic heart
failure. On top of the known anti-inflammatory activities of curcumin
attenuating neuroinflammation, this experimental evidence strongly suggests
that curcumin has the potential to prevent accelerated cognitive decline in
humans. Several animal studies have shown that curcumin improves cognitive
function. Randomized controlled trials in humans are limited but suggest that
curcumin could be safely and effectively used to slow cognitive decline. We
found in this observational cohort study that the consumption of curcumin-rich
curry in food was associated with the maintenance of higher levels of cognitive
functioning over time among community-dwelling middle-aged and older Asian
adults in Singapore. To our knowledge, this is the first longitudinal study
demonstrating the cognitive benefits of curcumin from natural dietary food
sources in humans. Curcumin exposure from dietary ingestion appears to offer
neuroprotection especially through its beneficial metabolic, antiplatelet and
cardioprotective properties. There is evidence that the combination of
piperine in black pepper with curcumin in turmeric increases the
bioavailability of curcumin by 2000% and inhibits the intestinal and hepatic
glucuronidation of curcumin. In this study, real-world observations of the
potential cognitive benefits of curcumin in humans were provided in a large
population-based cohort of community-dwelling older adults with follow-up over
three to five years. The consumption of dietary curcumin was associated with
the maintenance over time of higher functioning on attention, short-term
working memory, visual spatial constructional ability, language and executive
function among community-dwelling older adults. This suggests that,
notwithstanding its known anti-amyloid, anti-tau, antioxidant and
anti-inflammatory activities, curcumin exposure from dietary ingestion appears
to offer neuroprotection especially through its beneficial metabolic,
antiplatelet and cardioprotective properties. The results from the stratified
analysis support this by showing that among participants with pre-existing
metabolic and cardiovascular disease, curry consumption was associated with
enhanced performance on attention, working memory and language executive
function. In vitro and high-dose animal studies show that curcumin modulates
molecular pathways that restore glucose homeostasis, lipid metabolism,
endothelial function and insulin signaling and may thus offer potential
cardiovascular protective effect. These observations suggest that population
health in terms of healthy cognitive ageing and potential reduction of risks of
dementia could be enhanced by increased consumption of curcumin in a
turmeric-rich diet.
Potential Role of Curcumin for the Treatment of
Major Depressive Disorder
CNS Drugs | March
2022
Curcumin is the major biologically active polyphenolic constituent in the
turmeric plant (Curcuma longa) that has been shown to have antioxidant,
anti-inflammatory, neuroprotective, anticancer, antimicrobial, and
cardioprotective effects. Interest in curcumin as a treatment for mental health
conditions has increased and there is an expanding body of preclinical and
clinical research examining its antidepressant and anxiolytic effects. Cell
culture and animal studies have demonstrated that curcuminoids, and in
particular curcumin, have extensive biological activity, including antioxidant,
anti-inflammatory, neuroprotective, anticancer, antimicrobial, and
cardioprotective effects. Turmeric has traditionally been used in Indian folk
medicine to treat eye infections, skin wounds, respiratory conditions and
digestive complaints, and to reduce general inflammation. More recently,
interest in curcumin as a treatment for depression has increased and there is
an expanding body of research confirming antidepressant and anxiolytic effects
from its administration. There is an increasing body of research supporting the
efficacy of curcumin as a treatment for depression. Positive
antidepressant effects were reported in six of seven trials, with the only
non-significant finding identified by Bergman et al., where curcumin was used
as an adjunct to pharmaceutical antidepressants and administered for the
shortest treatment period of all the trials (5 weeks). Positive anxiolytic
effects from curcumin administration were also identified in four trials.
Interestingly, in this meta-analysis, an even larger treatment effect was
identified when examining the effects of curcumin on anxiety symptoms (Hedge’s
g = 2.62). In a meta-analysis conducted in 2016, it was concluded from subgroup
analyses that curcumin had the highest antidepressant effects when administered
to middle-aged adults, for longer treatment periods, and at higher doses.
Investigation of the Effect of Curcumin on Protein Targets in NAFLD Using
Bioinformatic Analysis
Nutrients | March
2022
Curcumin is a bioactive polyphenolic compound, isolated from Curcuma longa
Linn, which is endowed with diverse pharmacological activities. Curcumin
improves steatosis, inflammation, and fibrosis progression. Curcumin may
improve, or inhibit, progression of non-alcoholic fatty liver disease
(NAFLD)through activation/inhibition of non-alcoholic fatty liver disease
(NAFLD)-related genes. Numerous in-vitro and in-vivo investigations have
indicated that curcumin exerts a positive effect at each stage of non-alcoholic
fatty liver disease (NAFLD), improving both inflammation and the extent of fat
deposition. Curcumin was also shown to inhibit the progression from
non-alcoholic fatty liver disease (NAFLD) to fibrosis and decrease the risk of
liver cancer. Emerging from these studies, therefore, are data supporting the
significant clinical effect of curcumin on non-alcoholic fatty liver disease
(NAFLD). Curcumin exerts its anti-diabetic, cardioprotective, hepatoprotective,
neuroprotective, and antitumor effects via NFE2L2 signaling pathways. Curcumin
activates NFE2L2 signaling pathways in four ways. In a high-fat and
high-fructose diet (HFHFr) mouse model, NFE2L2 was downregulated, while
curcumin administration could reverse the abnormal serum biochemical parameters
of hepatic steatosis. Another animal study using carbon tetrachloride (CCL4)
induced liver damage showed that curcumin’s protective role in reducing
inflammation and oxidative stress was mediated through NFE2L2/HO-1 pathways. An
in-vitro study showed that curcumin, through activation of NFE2L2, can promote
lipocyte activation in stellate cells (HSCs) and repress hepatic fibrosis. In
this study, we identified 14 genes in non-alcoholic fatty liver disease (NAFLD)
that are likely to be the target of curcumin and observed that curcumin induces
or inhibits them. According to our results, this activity of curcumin was in
line with improving non-alcoholic fatty liver disease (NAFLD) based on
literature. We believe that the ongoing clinical trials investigating the
effect of curcumin on fatty liver could yield positive results in the future,
enhancing the therapeutic status of curcumin in this metabolic disorder.
Molecular Targets of Curcumin and Its Therapeutic Potential for Ovarian Cancer
Nutrition and Cancer | March
2022
Curcumin is a natural product found in the rhizome extract of Curcuma longa
and has been extensively used over the last decades for its unique biological
and medicinal properties, which include: having antioxidant, analgesic,
anti-inflammation, and anti-tumor activities. Curcumin exerts its anticancer
properties against ovarian cancer via multiple mechanisms: interfering with
cellular interactions necessary for metastasis and recurrence of OC cells,
increasing pro-apoptotic proteins as well as inducing or suppressing generation
of different molecules such as cytokines, transcription factors, enzymes,
protein kinases, and growth factors. Moreover, curcumin down-regulates various
signaling pathways such as PI3K/Akt, Wnt/β-catenin, JAK/STAT3, and MEK/ERK1/2
axes, which at least in part have a role in inhibiting further tumor
proliferation, growth, and angiogenesis. In this review, we overview the
potential of incorporating curcumin into the treatment of ovarian cancer.
Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction
Oxidative Medicine and Cellular Longevity | March
2022
Curcumin is a natural medicine containing phenol and quinone groups
extracted from turmeric in the ginger family. It is well known as a safe
dietary supplement worldwide. In several randomized, double-blinded, clinical
trial, patients with PCOS received curcumin (in doses of 500-1500 mg 3 times
daily for 1-3 months) or placebo. It is suggested that curcumin can effectively
improve blood glucose, insulin resistance, and hyperandrogenemia in PCOS.
Moreover, curcumin reportedly exerts numerous biological effects to manage
human diseases, including cancer and neurodegenerative and metabolic disorders.
Both curcumin gavage and aerobic exercise improved ovarian function.
Curcumin and aerobic exercise (irisin) can alleviate hyperandrogenism-induced
ER stress and suppress the IRE1α-XBP1 pathway, which prevented ovarian GC
apoptosis in PCOS-like rats, leading to the improvement in the ovarian
microenvironment and promotion of follicular development.
Curcumin
Suppresses Lead-Induced Inflammation and Memory Loss in Mouse Model and In
Silico Molecular Docking
Foods | March
2022
Curcumin is a polyphenol primarily extracted from turmeric, and has drawn
much attention in the field of natural drug discovery due to its excellent
therapeutic effects, such as its antioxidant, anti-inflammation,
anti-microbial, anti-arthritic, and anti-depressant activities. In addition,
curcumin can modulate cognitive dysfunction and astrocyte proliferation.
Research revealed that curcumin can suppress memory impairment and can
attenuate cognitive deficits. In mercury chloride-treated offspring mice,
curcumin treatment improved memory and learning activity, antioxidant profile,
and increased AChE, serotonin, and dopamine. Curcumin also downregulated the
AChE gene expressions. Curcumin is known to have a potent antioxidant
activity due to its capacity for chain-breaking, as well as the
hydrogen-donating phenolic groups in its structure. Much research has also
revealed the neuroprotective effects of curcumin, which operate via exerting
antioxidant effects and reducing oxidative damage. Curcumin exhibits great
promise as a therapeutic agent for a variety of cancers, as well as for
psoriasis, and Alzheimer’s disease. It has been reported that curcumin
suppresses aluminum- and Pb-induced oxidative neurotoxicity, alterations in
NMDA receptors that lead to decreased antioxidant enzyme activity, and AChE
dysfunctions. Thus, the present study has indicated that curcumin, a potent
antioxidant compound, ameliorated lipid peroxidation and oxidative stress
parameters in mice exposed to Pb, along with protecting against cholinergic
dysfunction. Curcumin co-treatment effectively suppresses Pb-induced brain
inflammation. Thus, Curcumin may completely bind with AchE to increase
enzymatic activity, which is predicted to have dose-dependent neuroprotective
effects, at least in part via exerting antioxidant and anti-inflammatory
effects, and reversing the Pb-induced alterations in transmitters and enzymes.
Cardioprotective effects of exercise and curcumin supplementation against
myocardial ischemia–reperfusion injury
Sport Sciences for Health |
March
2022
Exercise and curcumin individually provided cardioprotective effects
against ischemia–reperfusion-induced injury which appears to be associated with
an attenuation in mRNA expression of β-amyloid peptide precursor in addition to
processing enzymes and an increase in mRNA expression of neprilysin.
Curcumin Inhibits Papillary Thyroid Cancer Cell Proliferation
Analytical
Cellular Pathology | March
2022
Curcumin is a polyphenolic compound and a member of the Zingiberaceae
(ginger) family derived from turmeric plants. It has been extensively used in
Chinese medicine to treat various diseases, including inflammation and cancer.
Curcumin was found to participate in the process of pancreatic cancer,
colorectal cancer, and hepatocellular cancer by regulating specific lncRNAs and
miRNAs. In addition, curcumin can suppress PTC cell metastasis. Curcumin was
shown to enhance the anticancer activity of cisplatin in PTC cells and cancer
stem-like cells by regulating the JAK/STAT3 signaling. In conclusion, the
present study provides evidence that curcumin promotes apoptosis and inhibits
proliferation and the Warburg effect by inhibiting LINC00691 in B-CPAP cells.
Moreover, the specific molecular mechanism might be mediated through the Akt
signaling pathway. This study provides a theoretical basis for the treatment of
PTC with curcumin.
Curcumin as an Enhancer of Therapeutic Efficiency of
Chemotherapy Drugs in Breast Cancer
International Journal of
Molecular
Sciences | February
2022
Collectively, curcumin in combination with chemotherapy drugs may improve
their clinical application in breast cancer therapy, and it is of considerable
value to develop as an adjunct for combination chemotherapy with current drugs
to treat breast cancer. Curcumin is an ideal chemopreventive and
chemotherapy agent owning to its multitargeting function on various regulatory
molecules, key signaling pathways, and pharmacological safety. This review
aimed to elucidate the potential role of curcumin in enhancing the efficacy of
doxorubicin, paclitaxel, 5-fluorouracil, and cisplatin via combinational
therapy. Additionally, the molecular mechanisms underlying the chemosensitizing
activity of these combinations have been addressed. Overall, based on the
promising therapeutic potential of curcumin in combination with conventional
chemotherapy drugs, curcumin is of considerable value to develop as an adjunct
for combination chemotherapy with current drugs to treat breast cancer.
Effects of curcumin supplementation on metabolic parameters, inflammatory
factors and obesity values in women with rheumatoid arthritis: A randomized,
double-blind, placebo-controlled clinical trial
Phytotherapy
Research |
February
2022
Curcumin supplementation significantly decreased homeostatic model
assessment for insulin resistance (HOMA-IR), erythrocyte sedimentation rate,
serum levels of high-sensitivity C-reactive protein and triglycerides, weight,
body mass index, and waist circumference of patients compared with the placebo
at the end of the study (p < .05 for all). HOMA-IR and triglyceride levels
significantly increased within the placebo group.
Curcumin induces
autophagic cell death in human thyroid cancer cells
Toxicology in
Vitro |
February
2022
Curcumin acts as an autophagy inducer on many cancer cells. In the present
study, curcumin significantly inhibited the growth of thyroid cancer cells.
Autophagy was markedly induced by curcumin treatment as evidenced by an
increase in LC3-II conversion, beclin-1 accumulation, p62 degradation as well
as the increased formation of acidic vesicular organelles (AVOs). 3-MA, an
autophagy inhibitor, partially rescued thyroid cancer cells from
curcumin-induced cell death. Additionally, curcumin was found to exert
selective cytotoxicity on thyroid cancer cells but not normal epithelial cells
and acted as an autophagy inducer through activation of MAPK while inhibition
of mTOR pathways.
Effect of Curcumin in Experimental Pulmonary Tuberculosis:
Antimycobacterial Activity in the Lungs and Anti-Inflammatory Effect in the
Brain
International Journal of Molecular Sciences | February
2022
Curcumin is a natural product with antioxidant, anti-inflammatory and
antibacterial activities. Curcumin is a polyphenolic compound obtained from the
rhizomes of Curcuma longa, a rhizomatous native plant from South and Southeast
Asia that belongs to the family Zingiberaceae. Research has revealed that
curcumin has pleiotropic properties, including anti-inflammatory, antioxidant,
chemopreventive, chemotherapeutic activity, neuroprotective properties, and
antibacterial activity. The pleiotropic actions of curcumin are derived from
its complex chemistry and its ability to influence multiple signaling pathways.
Curcumin controls the inflammatory response by downregulating the activity of
the enzymes cyclooxygenase-2 (COX-2), lipoxygenase, and inducible nitric oxide
synthase (iNOS). In addition, curcumin suppresses the activation of nuclear
factor kappa B (NF-κB) activation; inhibits the production of the inflammatory
cytokines TNF-α, interleukin (IL)-1, -2, -6, -8, and -12, monocyte
chemoattractant protein (MCP) and migration inhibitory protein; and
down-regulates mitogen-activated and Janus kinases. In addition, curcumin
protects the brain from damage through the upregulated expression of the
transcription factor, the nuclear factor erythroid 2-related to factor 2 (Nrf2)
expression, and the hippocampal levels of brain-derived neurotrophic factor
(BDNF). Indeed, there is evidence that curcumin has a beneficial effect on
humans suffering from depression and anxiety, linked to curcumin
anti-inflammatory effects, dopamine release, antioxidant activity, and
neurotrophic factor regulation. Curcumin also resulted in a dose-dependent
increase in hippocampal BDNF in a model of depression. These data coincide with
our results, where we observed a significant increase in BDNF levels in the
hippocampus of animals with TB treated with curcumin, related to the
beneficial effect of curcumin on memory and the decrease in depression-like
behavior in this model. Curcumin protected from injury in a model of an
ischemic brain through the Akt/Nrf2 pathway. Curcumin has a neuroprotective
effect in a model of traumatic brain injury (TBI) associated with activating
the Nrf2 pathway. These data suggest that treatment with curcumin has a
beneficial effect on various neuroinflammatory and neurodegenerative diseases,
including those related to pulmonary TB. This investigation revealed the
efficacy of curcumin administration as a novel treatment for controlling
neuroinflammation in chronic infectious diseases such as pulmonary TB. In
addition, it is worth noting that curcumin had a therapeutic effect on lung
disease, indicating that curcumin might be used as a coadjuvant treatment in TB
chemotherapy.
Curcumin Ameliorates Cardiac Fibrosis
Frontiers in
Pharmacology | February
2022
The therapeutic potential of curcumin has been widely investigated,
including its utilization in various of cardiovascular diseases. Curcumin’s
health benefits has been well-established, including anti-tumor, anti-viral,
anti-oxidative stress, anti-inflammatory, anti-microbial, hypoglycemic etc.
Therapeutically, curcumin exhibits promising potential in preclinical as well
as clinical studies and is currently in human trials for a variety of
conditions, including metabolic syndrome, nonalcoholic fatty liver disease,
atherosclerosis, liver cirrhosis, depression, psoriasis, and Alzheimer’s
disease (Kocaadam and Şanlier, 2017). The immunomodulatory functions of
curcumin arise due to its interactions with cellular and molecular components
during inflammatory reactions. Dietary exposure to 40 mg/kg curcumin for 5
weeks showed enhanced IgG levels in rats, suggesting an improvement in immune
function after curcumin intervention (South et al., 1997). Curcumin has also
been shown to regulate macrophage polarization by increasing the M2 phenotype
marker CD163 together with the anti-inflammatory cytokine IL-10 and decreasing
the M1 phenotype marker CD86 along with the pro-inflammatory cytokines TNF-α
and IL-6 (Li et al., 2017). Curcumin significantly ameliorated the inflammation
process subsequent to myocardial infarction, reflected by decreased expression
of CD68+ and CD3+ cells, accompanied by dramatically improved cardiac function
compared with the placebo group. In addition, cardiac fibrosis is inhibited by
curcumin administration. Mechanistically, we discovered that curcumin
significantly downregulated pro-inflammatory cytokines in macrophages. Curcumin
improves cardiac function and reduces cardiac fibrosis after myocardial
infarction. Curcumin has roles in various cardiovascular diseases, including
ischemic heart, pressure overload heart, and metabolic disorder-related cardiac
diseases. It is well-established that curcumin can directly exerts
cardio-protective effect by targeting cardiomyocyte through various of
signaling pathway, like disrupts the p300/GATA4 complex and represses
agonist-and p300-induced hypertrophic responses in cardiomyocytes (Morimoto et
al., 2008)or activates the autophagy by upregulating AMPK and JNK1 to alleviate
the apoptosis of cardiomyocytes under ischemic stimulation (Yao et al., 2018).
In summary, our study revealed that the administration of curcumin
significantly ameliorated inflammation in the acute phase, as reflected by the
promotion of macrophage apoptosis, accompanied by decreased pro-inflammatory
cytokine secretion, including IL-6, IL1b, and TNF-α. These findings
suggest that curcumin has potential as a potent therapeutic target in treating
adverse remodeling in ischemic heart disease.
Curcumin sensitizes response
to cytarabine in acute myeloid leukemia by regulating intestinal microbiota
Cancer Chemotherapy and Pharmacology | February
2022
Curcumin is a natural phenolic compound extracted from curcuma longa, which
exerts a wide range of biological effects, such as anti-tumor,
anti-inflammatory, anti-oxidation and anti-fibrosis. Moreover, Curcumin was
also reported to affect energy metabolism to increase energy expenditure as
well as improve insulin sensitivity in obese mice]. Energy metabolism also
plays crucial roles in response to chemotherapy. Several studies have reported
that targeting energy metabolism could sensitize resistant cells to
chemotherapy, such as oxidative phosphorylation inhibitor redirected metabolism
toward glycolysis to sensitize resistant cells to cytarabine (Ara-C) in AML.
Curcumin could affect intestinal microbiota to prevent renal failure.
Conversely, intestinal microbiota could also enhance the effect of Curcumin in
ameliorating HFD-induced obesity by enhancing Ucp1-dependent thermogenesis
through regulating bile acids metabolism, suggesting the interaction between
intestinal microbiota and Curcumin in curing diseases. Curcumin resulted in
strengthening intestinal intact, leading to reduced transfer of bacteria (or
their metabolites) to the blood, causing SQLE inhibition. In conclusion, we
demonstrated that Curcumin sensitizes response to Ara-C by regulating
microbiota and strengthening intestinal intact is promising in chemoresistant
therapy.
Curcumin supplementation in the rhesus monkey: effects on cognitive
decline and neuroinflammation
Boston University Theses &
Dissertations |
February
2022
Curcumin, the active ingredient in turmeric, is a polyphenol nutraceutical
with potent anti-inflammatory and antioxidative effects. Several ongoing
research studies are underway to explore this potential anti-aging compound.
Curcumin treatment improved performance on object reversal testing, with
treated monkeys making fewer perseverative type errors. We demonstrated that
curcumin treatment did affect morphological features of microglia specifically
within the while matter. Within the white matter, curcumin treatment was
associated with a significant increase in microglial ramification, evidenced by
greater process length, number of nodes and convex-hull area and volume.
Increased microglial ramification suggests greater likelihood of microglial
surveillance within the white matter associated with curcumin treatment. While
our findings show the benefit of curcumin supplementation on cognitive
performance and its effects on microglial morphology, further study is needed
to understand the precise changes that curcumin supplementation may have on
inflammation.
Protective Effects of Curcumin in Cardiovascular
Diseases—Impact on Oxidative Stress and Mitochondria
Cells |
February
2022
In this review, we will highlight the impact of curcumin on age-related
cardiovascular dysfunction, adipose tissue, and obesity, as well as its
protective effects in atherosclerosis and myocardial infarction. Curcumin can
positively affect different risk factors for CVDs and the outcome in the
diseases themselves which has been shown in a number of animal models. More
importantly, it is effective against cardiovascular diseases and has shown a
promising impact on cardiovascular diseases in clinical studies. Already more
than 20 years ago, it was shown that piperine, an alkaloid responsible for the
pungency of black pepper, dramatically increases the serum levels of curcumin
in rats and humans.
A New Perspective on the Treatment of Alzheimer’s
Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?
Oxidative Medicine and Cellular Longevity | February
2022
Curcumin, a natural compound isolated from C. longa, has multiple
applications in treatment of various diseases such as cardiovascular diseases,
liver disease, obesity, cancer, inflammatory diseases, and aging. Besides these
applications and activities, curcumin has been reported to be effective in many
neurodegenerative diseases. Studies have shown that curcumin can lead to many
improvements in the pathological process of Alzheimer’s disease. Its mechanisms
of action can be classified as (I) sustaining homeostasis of the inflammatory
system, (II) increasing the clearance of toxic substances from the brain, (III)
scavenging free radicals and inducing antioxidant elements, and (IV) binding
and limiting aggregation of misfolded proteins. In addition to the effects of
curcumin on neurodegenerative diseases, especially Alzheimer’s disease, it has
been reported that curcumin can be beneficial in the management of sleep
deprivation (SD) and SD-induced neurological consequences as well. The effects
of curcumin on the medial prefrontal cortex (mPFC), the protective potential on
the dendritic trees from shortening and shedding induced by chronic SD, and the
effects of SD-induced memory impairments have been demonstrated by in vivo
studies.
Curcumin protects rats against gentamicin-induced nephrotoxicity by
amelioration of oxidative stress, endoplasmic reticulum stress and apoptosis
Pharmaceutical Biology | February
2022
Curcumin is a major yellow phenolic pigment of turmeric that is extracted
from rhizome of Curcuma longa L. (Zingiberaceae), a spice widely cultivated in
tropical countries in south and southeast Asia, such as China, India and
Thailand (Wanninger et al. 2015). Numerous studies have shown that curcumin has
excellent antioxidant and anti-inflammatory properties. It has the ability to
inhibit free radical generation, scavenge ROS and induce an antioxidant
response. Moreover, curcumin has also exerted renoprotective effects in several
experimental models, including diabetic nephropathy, chronic renal failure,
ischaemia and reperfusion; it also combats nephrotoxicity protecting against
renal injury from oxidative stress (Trujillo et al. 2013). Interestingly,
curcumin treatment helps protect against acute myocarditis by inhibition
of cardiac oxidative and ER stress-mediated apoptosis (Mito et al. 2011).
Curcumin eliminates the hydroxyl radical, superoxide radical, singlet oxygen,
nitrogen dioxide and NO (Ruby et al. 1995; Sreejayan and Rao 1997) and has been
shown to inhibit hydrogen peroxide induced oxidative injury in a renal cell
line (Farombi and Ekor 2006) and prevented reduced activity of antioxidant
enzymes including glutathione peroxidase and SOD in rat remnant kidney (Tapia
et al. 2012). These results demonstrated that curcumin inhibited oxidative
stress and restoration of the antioxidant enzymes leading to improved renal
function and rescued kidney damage in GM-induced nephrotoxicity. These
results were in line with the previous report demonstrating that curcumin
ameliorated high glucose-induced neural tube defects by suppressing ER stress,
caspase activation and apoptosis (Afrin et al. 2015). Moreover, curcumin
treatment also prevented cell death induced by H2O2 (Wang et al. 2016). It
might be suggested that curcumin attenuated ER stress-induced apoptosis in
GM-induced nephrotoxicity, probably associated with the antioxidative activity.
The GM-induced nephrotoxicity was contributed by the increasing of oxidative
stress, ER stress activation which eventually resulted in the apoptosis cell
death. These events were restored by the pre-treatment of curcumin based on its
activities to reverse several hallmarks of nephrotoxicity. These findings
emphasized the potential therapeutic use of curcumin to be developed as an
alternative treatment for nephrotoxicity.
Neuroprotective effects of
curcumin on the cerebellum in a rotenone-induced Parkinson’s Disease Model
CNS Neuroscience & Therapeutics | February
2022
Curcumin has a lipophilic property, can pass through cell membranes, and
exerts intracellular effects. Curcumin crosses the blood brain barrier
and is also detected in cerebrospinal fluid. The strong antioxidant properties
of curcumin scavenge reactive oxygen species and inhibit lipid peroxidation. In
one study, administration of curcumin improved behavioral alterations,
oxidative damage, and mitochondrial enzyme dysfunction induced by the
administration of rotenone in mice. Curcumin also restored electrical activity
in the hippocampus altered by rotenone. Curcumin is a strong antioxidant that
minimizes oxidative stress in vivo and in vitro. Curcumin exerts various
beneficial effects in treating and preventing neurodegenerative diseases, such
as stroke and Alzheimer's disease. Additionally, several studies demonstrated
curcumin's ability to inhibit key Parkinson's disease-associated features,
including ROS formation, apoptosis, cytokine production, oxidative damage, and
cognitive impairment in cell lines and experimental animals. Moreover,
Khuwaja et al. demonstrated that curcumin helps stop Parkinsonism and has
therapeutic potential. Based on the results of this study, rotenone causes
Purkinje cell death and astrogliosis by increasing oxidative stress in the
cerebellar cortex. Administration of curcumin prevented these effects.
Furthermore, cholinergic neurotransmission alterations induced by rotenone were
suppressed by curcumin, thus confirming the behavioral and histological
findings. This shows that curcumin attenuated the neurotoxic effects and
degenerative histological changes in the cerebellar cortex and alleviated
oxidative stress in a Parkinson's disease rat model. Thus, curcumin could
have a role in therapeutic strategies for cerebellar affection related to
Parkinson's disease.
Supplements immunologist takes every day to strengthen
immune system
CNBC | February
2022
Curcumin is the main active ingredient in turmeric root and has been shown
to bestow multiple health benefits. In fact, there are more than 120 human
clinical trials showing the effectiveness of curcumin in treating diseases
ranging from autoimmunity to Alzheimer’s disease. The magic of curcumin is how
it decreases inflammation at multiple levels in the body, not only helping with
symptom relief from pain and arthritis but also blocking inflammatory cytokines
driving autoimmune disease, heart disease and diabetes. It also improves the
health of our gut bacteria, which adds to our overall immune health. Because
curcumin is not absorbed well and one would have to eat copious amounts of
turmeric root to have significant benefits, I recommend supplementing with
1,000 milligrams per day with food.
Curcumin alleviates hepatic steatosis by
improving mitochondrial function in postnatal overfed rats and fatty L02 cells
through the SIRT3 pathway
Food & Function | February
2022
It was concluded that postnatal overfeeding damaged mitochondrial
biogenesis and antioxidant response, and increased hepatic lipids and the
severity of high-fat-induced NAFLD, while curcumin alleviated hepatic
steatosis, at least partially, by enhancing mitochondrial function through
SIRT3.
Therapeutic Applications of Curcumin in Diabetes: A Review and
Perspective
BioMed Research International | February
2022
The curcumin molecule exhibits a multitargeting ability in various
pathological conditions, which allows translation into a therapeutic or
nutraceutical agent. Curcumin can support balance for oxidative and
inflammatory conditions, metabolic syndrome, arthritis, anxiety, and
hyperlipidemia. Curcumin has antioxidant, antiamyloid, antimicrobial,
antineoplastic, immune-modulating, and neuroprotective effect. Curcumin also
showed antidepressant activity through modulating the release of serotonin and
dopamine. Diabetics are not able to metabolize well glucose due to defects in
insulin secretion and/or action, and curcumin is capable to exert a therapeutic
effect playing a critical role on β-cell functions. Several studies have been
shown the high therapeutic properties of curcumin in hyperglycemia, diabetic
wound healing, diabetic neuropathy, diabetic cardiomyopathy, and diabetic
retinopathy and cataract.
Curcumin supplementation in pediatric patients: A
systematic review of current clinical evidence
UWA Medical School |
February
2022
This systematic review was designed to determine the clinical efficacy and
safety of curcumin supplementation for pediatric patients based on clinical
trials in children. We systematically searched electronic databases including
PubMed, EMBASE, Web of Science, and Scopus for all studies that investigated
curcumin administration in the pediatric population without any time frame
limitation. Finally, we identified 16 studies for this review. Clinical
efficacy and safety of curcumin were assessed in children with inflammatory and
immune disorders (including asthma, inflammatory bowel disease (IBD), and
juvenile idiopathic arthritis (JIA)), metabolic disorders, autosomal dominant
polycystic kidney disease (ADPKD), cystic fibrosis (CF), tetralogy of Fallot
(TOF), and infectious diseases. Curcumin was administered in a wide range of
doses (45 mg-4,000 mg daily) and durations (2-48 weeks). Overall, curcumin was
well tolerated in all studies and improved the severity of inflammatory and
immune disorders and metabolic diseases. However, more studies are needed to
clarify the role of curcumin supplementation among children with ADPKD, CF,
TOF, and infectious diseases.
Effect of curcumin on body mass index and
glycemic indices in females with PCOS: a systematic review and meta-analysis of
randomized controlled trial
Nutrition & Food Science | February
2022
Random-effects meta-analysis showed significant effects of curcumin on
fasting blood sugar (FBS) (−3.62 mg/dl, 95% CI [−5.65, −1.58], p-value < 0.001,
I2 = 0.0%), insulin level (−1.67 µU/mL, 95% CI [−3.06, −0.28], p-value = 0.018,
I2 = 0.0%) and homeostasis model of assessment insulin resistance (HOMA-IR)
(−0.42, 95% CI [−0.76, −0.09], p-value < 0.01, I2 = 0.0%).
A Plethora of
Actions of Curcumin - A Magical Agent for Treatment of Wide Range of Diseases
Varying from Neuroinflammatory Disease (Alzheimer's disease, Parkinson's
disease) IBD to DM and CVD, NAFLD, NASH Along with Various Cancers
Acta
Scientific | February
2022
Curcumin has been evaluated for its biological actions: Neuroinflammation;
Alzheimer’s disease (AD); parkinson’s disease (PD); antioxidant actions; other
anti-inflammatory actions; cardio protection; hepatoprotection in liver
fibrosia; non alcoholic fatty liver disease (NAFLD); non alcoholic
steatohepatitis (NASH); Anti cancer actions. We observed a total of over 3000
articles and selected 53 articles for this review with the journals
constraints of up to 50 references. Here we have reviewed in detail the
mechanism of action of Curcumin in various above mentioned diseases along with
transcription factors involved. Recently even in COVID its use has got
documented. In case of cancers, usually it is a good coagent with other
chemotherapeutic drugs, might hamper human papilloma virus (HPV) infection as
well as avoid cancer cervix generation. In case of NASH, or liver cirrhosis its
use with beta blockers might aid in conversion back towards normalcy.
Curcumin's pleiotropic actions include inflammatory diseases like cancer, CVD,
arthritis, atherosclerosis, DM, gastric disease, inflammatory bowel disease
(IBD), psoriasis, HIV etc. Curcumin is accepted to be a molecule having
the capacity to avoid/slowdown the pathological events resulting in age –
associated dementia, cognitive decrease, or depression. Additionally, various
evaluations have pointed that Curcumin is a potential anticancer treatment in
case of human papilloma virus (HPV) infection, in addition to primary as well
as malignant squamous cell cancer.
Curcumin Alleviates Dextran Sulfate
Sodium-induced Colitis in Mice Through Regulating Gut Microbiota
Molecular
Nutrition & Food Research | February
2022
Results showed that oral administration with curcumin relieved macroscopic
pathological manifestations, e.g. colon length and histological change.
Moreover, it enhanced intestinal barrier via increasing expression of tight
junction proteins, e.g. occludin, ZO-1, claudin-3; alleviated DSS-induced
intestinal apoptosis via suppressing caspase-3 pathway; mitigated intestinal
inflammation via inhibiting the MAPK/NFκB/STAT3 pathway. We also noticed that
curcumin is beneficial for modulating abundance of some specific bacteria,
including Akkermansia, Coprococcus, Roseburia, and Turicibacter, as well as
families such as F16, Enterococcaceae, and Aerococcaceae. Most of the altered
bacteria by curcumin are highly correlated with colitis-associated parameters.
Curcumin shows therapeutic potential against colitis. It may be served as
alternative medicine or adjuvant therapy in the treatment of colitis.
Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A
Systematic Review of Clinical Trials
Nutrients | January
2022
The natural spice curcumin has received recent attention in treating
diseases involving perturbations of the immune system and inflammation
responses, such as COVID-19. Curcumin and other curcuminoids are the main
bioactive ingredients of turmeric (Curcuma longa). They have been used for
millennia in the traditional medicines of multiple cultures due to their
anti-inflammatory, antioxidant, antibacterial, antiviral, antidiabetic, and
neuroprotective properties. Curcuminoids have received approval from the USA
Food and Drug Administration (FDA), and these compounds have good tolerability
and safety. Furthermore, they have already been tested with some successes in
clinical trials targeting various diseases. Curcumin treatment—as an adjunct
therapy—helps restore the balance between the pro-inflammatory and
anti-inflammatory pathways and, at the same time, reduces the persistence of
common COVID-19 symptoms and decreases mortality. Together, these findings
support curcumin formulations as adjunctive therapy to reduce the
hyper-inflammatory effect in COVID-19 patients and improve patient outcomes.
Curcumin treatment led to the amelioration of cytokine storm manifestation by
reducing pro-inflammatory factors and stimulating anti-inflammatory pathways.
Thus, these findings suggest that curcumin treatment may alleviate COVID-19
symptoms by restoration of the pro-inflammatory and anti-inflammatory balance.
Furthermore, the study by Pawar et al. showed that curcumin-piperine
supplementation led to fewer thromboembolic episodes following recovery from
COVID-19 infections.
Cancer Chemoprevention: A Strategic Approach Using
Phytochemicals
Frontiers in Pharmacology | January
2022
Curcumin (diferuloylmethane), a polyphenol isolated from Curcuma longa is
the most studied phytochemical as a chemopreventive. Curcumin displays a wide
variety of pharmacological functions such as anti-inflammatory agent,
anti-mutagenic agent, antineoplastic agent, hepatoprotective agent,
nutraceutical, anti-microbial agent, anti-oxidant agent, and immunomodulator.
It has been shown to have significant roles in prevention, treatment and chemo
sensitization of cancer cells (Pavan et al., 2016). Studies have established
the anti-proliferative, anti-angiogenic, anti-metastatic, and pro-apoptotic
properties of curcumin (Anto et al., 2002; Puliyappadamba et al., 2010; Bava et
al., 2011; Vinod et al., 2013). We have reported that curcumin exhibits
potential chemopreventive effect against nicotine-induced survival signalling
in lung cancer cells. We found that it down-regulates multiple survival signals
induced by nicotine in lung cancer cells irrespective of their p53 status
(Puliyappadamba et al., 2010). Another study conducted in our laboratory
revealed its chemopreventive efficacy against the lung carcinogenesis induced
by B (a)P, a potential environmental carcinogen found in cigarette smoke and
deep-fried food, in Swiss albino mice (Puliyappadamba et al., 2015). Curcumin
treatment has a significant impact on improving the general health of
colorectal cancer patients by enhancing expression of p53 molecules in tumour
cells and also by promoting the apoptosis of tumour cells (He et al., 2011;
Pricci et al., 2020). Curcumin intake causes the down-regulation of NF-kB,
COX-2 and phosphorylated STAT3 in peripheral blood mononuclear cells from
patients with pancreatic cancer (Dhillon et al., 2008). It has been reported
that, daily curcumin intake leads to a significant and dose-dependent reduction
in spontaneous ovarian cancer incidence and tumor growth in Hen ovarian cancer
model indicating a significant role of curcumin as a chemopreventive strategy
for ovarian cancer (Sahin et al., 2018). The administration of curcumin to
paediatric patients with relapsed brain tumours undergoing chemotherapy
increased their response compared with the controls (Wolff et al., 2012).
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of
Microglia Activation
Molecules | January
2022
Curcumin is a natural compound with a polyphenolic structure. This turmeric
extract derives from the rhizome of the Curcuma longa, a member of
Zingiberaceae, and shows a wide range of biological and pharmacological
activities including antioxidant, anti-inflammatory, antimicrobial,
immunomodulatory, and anti-tumor activity. Curcumin is a widely studied
polyphenol isolated from Curcuma longa with a variety of pharmacologic
properties. It is well-known for its healing properties and has been
extensively used in Asian medicine to treat a variety of illness conditions.
The number of studies that suggest beneficial effects of curcumin on brain
pathologies and age-related diseases is increasing. Curcumin is able to inhibit
the formation of reactive-oxygen species and other pro-inflammatory mediators
that are believed to play a pivotal role in many age-related diseases. Curcumin
has been recently proposed as a potential useful remedy against
neurodegenerative disorders and brain ageing. In light of this, our current
review aims to discuss the potential positive effects of Curcumin on the
possibility to control inflammaging emphasizing the possible modulation of
inflammaging processes in neurodegenerative diseases. Curcumin as dietary
phenolic compound should be considered as a pharmacological support for
longevity, especially in neurodegenerative and neuroinflammatory diseases, due
to its activity via declining oxidative stress, modulating signal transduction
and gene expression. Curcumin, in fact, is effective as an immune enhancer in
modulating systemic inflammation and brain pathologies through multiple
communication mechanisms and, for this reason, is hopefully a particularly
promising natural agent in counteracting the damages of aging and
neurodegenerative diseases. In this respect, the possible interventions by
curcumin on microglia suggest the possibility of this natural product to
mediate regulation of microglia phenotypes and its functions and also to
control redox imbalance and neuroinflammation, thus suggesting a possible use
of curcumin as therapeutic agent in preventing and managing major chronic
inflammatory disorders typical of the inflammaging process, including brain
diseases such as Alzheimer’s disease, Parkinson’s disease, and Multiple
Sclerosis. Hence, once again, attention is paid to the modulatory potential of
curcumin in its ability to mediate the anti-inflammatory effects and
consequently to positively influence immunity and brain aging. Therefore, the
use of curcumin as an anti-inflammatory agent with inhibitory effects on
microglial transformation could be a valid and promising approach for the
treatment of neurodegenerative disorders. Multiple lines of evidence show that
the involvement of microglial cells in brain neuroinflammation process typical
of aging may be a target for pharmacological interventions. The
anti-inflammatory activity of curcumin in microglia is ascribable to the
ability of this molecule to inhibit many pro-inflammatory mediators by impeding
inflammatory cascades and heightening endogenous anti-inflammatory mediators
where curcumin may act as an immunomodulator. In line with what emerges from
this review, there is evidence that the combination of standard protocols or
new therapies with the use of curcumin-based formulations could be a desirable
approach in the containment and treatment of the inflammaging process,
including that related to the brain.
The Multifaceted Actions of Curcumin
in Obesity
Natural Products and Human Diseases | January
2022
Crcumin, the active ingredient in turmeric, has attracted considerable
research interest in tracking down the possible effects in protection against
obesity and obesity-related comorbidities. According to the existing
literature, curcumin may regulate lipid metabolism and suppress chronic
inflammation interacting with white adipose tissue, which plays a central role
in the complications associated with obesity. Curcumin also inhibits the
differentiation of adipocyte and improves antioxidant properties. In the
present review, we sought to deliberate the possible effects of curcumin in
downregulating obesity and curtailing the adverse health effects of obesity.
Curcumin and Weight Loss: Does It Work?
International Journal of
Molecular
Sciences | January
2022
Curcumin is a polyphenolic compound that represents the most important
curcuminoid isolated from the rhizome of the plants. It is believed that
curcumin possess subtle effects through multiple mechanisms and biochemical
targets, collectively leading to substantial health benefits. This indicates
that this compound has potential for preventing (and, in the future, treating)
obesity. Curcumin has many properties, including antioxidant. The role of
antioxidants during the occurrence of oxidative stress is important, which in
turn may contribute to the prevention or delay of the development of many
diseases (including civilizational) and their possible complications.
Therefore, naturally derived antioxidants such as curcumin are of high clinical
value. The anti-inflammatory effect of curcumin is equally significant.
Curcumin inhibits and regulates tissue production and secretions of
pro-inflammatory cytokine, such as interleukins or tumor necrosis factor alpha
(TNF-α). Curcumin is a potential anti-cancer agent because of its
multidirectional properties with regard to the signaling/molecular pathways.
Curcumin possesses the ability to modulate the core pathways involved in cancer
cell proliferation, apoptosis, cell cycle arrest, paraptosis, autophagy,
oxidative stress and tumor cell motility. Curcumin and Curcuma longa extract
inhibit the growth of microorganisms, both G(+) and G(-) bacteria, which often
cause human infectious diseases. Curcumin is known to have an antiviral effect;
it also has been suggested as a potential treatment option for patients with
COVID-19. Curcumin has an anti-diabetic effect through, for example, enhancing
glucose uptake and improving pancreatic beta cell function. In addition,
curcumin contributes to the reduction of the gluconeogenesis process and to the
increase of glucokinase activity. Curcumin was able to restore oxidative stress
and DNA methyltransferase functions against diabetic retinopathy. Moreover,
curcumin has shown anti-lipidemic effects. There are animal model studies on
the use of curcumin in pregnancy. Due to the anti-inflammatory activity of this
compound, the possibility of using this compound in the treatment of
complications of pregnancy has been suggested, including Gestational Diabetes
Mellitus, PreTerm Birth, Preeclampsia and exposure to toxic agents and
pathogens. Other activities of curcumin worth mentioning include immune
modulation, cardiovascular protection, anti-pulmonary fibrosis, anti-chronic
obstructive pulmonary disease and anti-dementia activity. There is a growing
scientific interest in curcumin’s therapeutic potential. Indeed, more and more
clinical trials based on curcumin administration have been published or are
underway. Curcumin is a promising natural bioactive compound which possesses
numerous pharmacological activities. It shows multiple mechanism of action and
can affect cellular biochemical and physiological regulation. In pharmacies,
there are more and more preparations containing curcumin recommended for the
prevention of obesity.
Curcumin alleviates restraint stress-induced learning
and memory deficit and activity
Behavioral Neuroscience | January
2022
Several investigations have reported that curcumin has a protective effect
against stress disturbance. The present study is designed to investigate the
effects of curcumin on learning and memory, activity, biochemical, morphology
changes, and apoptosis in the hippocampus and prefrontal cortex of restraint
stress rats. Curcumin inhibited and reversed the changes of stress induced in
the prefrontal cortex and hippocampus of the rats. These findings provided
evidence for the protective effect of curcumin therapy on biochemical,
morphology, and behavioral changes induced by restraint stress.
Curcumin
improves atherosclerosis by inhibiting the epigenetic repression of lncRNA MIAT
to miR-124
Vascular | January
2022
Curcumin has protective effect on atherosclerosis. Curcumin suppressed
inflammation in atherosclerosis mouse model and ox-LDL-induced cell model.
Curcumin relieved ox-LDL-induced cell inflammation. MIAT/miR-124 axis mediated
the effect of curcumin on atherosclerosis and altered cell apoptosis and
proliferation, both in vivo and in vitro. These data further support the
application of curcumin in control of atherosclerosis advancement.
Effect of
curcumin supplementation on muscle damage, antioxidant status and inflammatory
factors after successive simulated taekwondo competitions
Science
& Sports |
January
2022
Creatine kinase (CK), lactate dehydrogenase (LDH) and Malondialdehyde (MDA)
increased significantly after the competition in placebo group compared to
Curcumin supplemented group. Total antioxidant capacity (TAC), significantly
increased in Curcumin supplemented compared to placebo group after the
competition. Based on the results of this study, Curcumin supplementation has
positive effects on reducing muscle damage and oxidative stress.
Curcumin
Induces Immunogenic Cell Death In Murine Colorectal Carcinoma
Pharmacological Research | January
2022
Curcumin, a compound found in the rhizome of Curcuma longa, is known to
impair the function in cancer cells. This event triggers apoptosis in
curcumin-treated cells and can be an important mechanism of the pharmacological
effects attributed to curcumin. The present work suggests that curcumin is an
inducer of immunogenic cell death. This observation brings more insights
into the mechanism of action of curcumin. It has already been shown that the
efficacy of certain cancer therapies, such as anthracycline-based chemotherapy,
photodynamic therapy, and radiotherapy, also rely on their ability to reinstate
cancer immunosurveillance. Circumventing the immune evasion strategies deployed
by cancers and reeducating the host immune system to detect and clear tumor
cells can be used as strategies to treat cancer. Thus, the use of curcumin not
only to directly kill cancer cells, but also to help inducing an immune
response against tumor antigens is an alternative that can be explored in
future studies.
Dietary curcumin restores insulin homeostasis in
diet-induced obese aged mice
Aging | January
2022
Curcumin is a bioactive polyphenolic compound extracted from the herb
Curcuma longa. Curcumin treatment maintains insulin homeostasis during
aging and dietary challenge that is mediated by hepatic IDE. It has
antioxidant, anti-inflammatory, and anti-diabetic properties which should
mitigate age-associated diseases. Curcumin supplementation suppresses
body weight gain and fat accumulation in aged mice. Its basic mechanism of
action as an anti-diabetic therapeutic agent was largely unknown however we
previously demonstrated that curcumin supplementation increases insulin
sensitivity in hepatocytes by upregulating hepatic IDE expression and preserved
islet integrity in a diet-induced obese (DIO) mouse model. Curcumin changes
hepatic gene expression profiling and supplementation preserves pancreatic
islet integrity in aged mice. Furthermore, we enumerated various cellular and
molecular events in the insulin signaling pathway regulated by curcumin.
Dietary curcumin alters gene expression associated with insulin signaling and
senescence pathways in the aged mice. In this study, we sought to determine if
curcumin supplementation during a nutrient stressor known to cause insulin
resistance in aged mice might be beneficial to preserving hepatocytes in an
insulin-sensitive phenotype while protecting β -cells from the need to
compensate for insulin resistance. In summary, our study illustrates that
curcumin supplementation in aged individuals is likely to play a role in
mitigating reduced hepatic insulin sensitivity due to aging per se and dietary
challenges. It seems convincing that curcumin positively regulates insulin
sensitivity in hepatocytes because of the upregulation of IDE that is reflected
in reduced demand for increased insulin secretion and synthesis. Thus, curcumin
is a potent, natural therapeutic agent which acts in a multifaceted manner to
protect aging-induced metabolic disorders.
Nrf2-Related Therapeutic Effects
of Curcumin in Different Disorders
Biomolecules | January
2022
Curcumin is a natural polyphenol with antioxidant, antibacterial,
anti-cancer, and anti-inflammation effects. This substance has been shown to
affect the activity of Nrf2 signaling, a pathway that is activated in response
to stress and decreases levels of reactive oxygen species and electrophilic
substances. Nrf2-related effects of curcumin have been investigated in
different contexts, including gastrointestinal disorders, ischemia-reperfusion
injury, diabetes mellitus, nervous system diseases, renal diseases, pulmonary
diseases, cardiovascular diseases as well as cancers. In the current review, we
discuss the Nrf2-mediated therapeutic effects of curcumin in these conditions.
The data reviewed in the current manuscript indicates curcumin as a potential
activator of Nrf2 and a therapeutic substance for the protection of cells in
several pathological conditions.
Curcumin alters distinct molecular pathways
in breast cancer subtypes
Cancer Reports | January
2022
Curcumin is well known for its anticancer properties. Its cytotoxic
activity has been documented in several cancer cell lines, including breast
cancer. The pleiotropic activity of curcumin as an antioxidant, an
antiangiogenic, antiproliferative, and pro-apoptotic, is due to its diverse
targets, such as signaling pathways, protein/enzyme, or noncoding gene.
Curcumin, a polyphenol extracted from turmeric, is well known for its
multifaceted properties like anti-inflammatory, antioxidant, anti-bacterial,
anti-malarial, and anticancer. Clinical and preclinical studies have validated
the role of curcumin in varied human chronic diseases, including cancer. The
therapeutic potential of curcumin can be attributed to its capability to
regulate both epigenome and transcriptome. In conclusion, curcumin regulates
miRNA and mRNA in a cell type specific manner. Curcumin altered different
pathways in breast cancer cell lines such as cell cycle, migration, invasion,
and so forth. The integrative analysis led to the detection of miRNAs and mRNAs
pairs, which can be used as biomarkers, associated with carcinogenesis,
diagnosis and treatment response in breast cancer.
Curcumin exerts a
protective effect against obesity and liver injury induced by an atherogenic
diet
Functional Foods in Health and Disease | January
2022
Background: Curcumin is a natural yellow polyphenol extracted from the
turmeric rhizome (Curcuma longa). Curcumin is known for its potential
therapeutic properties as an analgesic, anti-inflammatory, antioxidant,
antimicrobial, hepatoprotective, and anti-mutagenic, although some of these
biological activities remain unproven. Epidemiological studies have shown a
positive relationship between high-fat diets and diet-related chronic diseases.
We hypothesized that some adverse effects of consuming atherogenic or high-fat
diets can be ameliorated by curcumin supplementation. This study provides
supporting evidence to confirm the beneficial effects of curcumin from the
point of view of functional food science.
Age-related alterations to
working memory and to pyramidal neurons in the prefrontal cortex of rhesus
monkeys begin in early middle-age and are partially ameliorated by dietary
curcumin.
Neurobiology of Aging | January
2022
Curcumin-treated subjects exhibit better working memory ability and less
neuronal excitability. Middle-aged subjects given curcumin exhibited better
workng memory performance and less neuronal excitability compared to control
subjects. These findings suggest that the appropriate time frame for
intervention for age-related cognitive changes is early middle age, and points
to the efficacy of curcumin in delaying working memory decline.
Curcumin
inhibits the invasion and metastasis of triple negative breast cancer
Journal of Ethnopharmacology | January
2022
Modern pharmacological studies have found that curcumin has many kinds of
pharmacological activities of anti-inflammatory, anti-tumor, anti-angiogenesis,
anti-metastasis and anti-multidrug resistance. Curcumin has good
anti-inflammatory (Lei et al., 2014), anti-oxidation (Santosh et al., 2007),
and reducing the levels of ROS(Sethi et al., 2008). It can also inhibit the
activation of multiple pathways such as NF-κB (Cho et al., 2007) and IL-1α,
IL-6 and other gene expression (Momeni and Eskandari, 2017). A recent study
showed that curcumin inhibited the expression of HIF-1 by degrading ARNT in
cancer stem-like cells, thereby improving the hypoxia environment and promoting
the early apoptosis of breast cancer cells (Sarighieh et al.,2020). Curcumin
could significantly reduce cancer proliferation and the expression level of
PLAC8 in MCF-7/TAM cells through proteasome and PLAC8/MAPK signaling pathways
which showed that curcumin might be a potential adjuvant therapeutic agent for
the treatment of tamoxifen-resistant patients (Mao et al.,2021). Moreover,
curcumin, as the main ingredient of curry, has no obvious toxic and side
effects according to toxicological studies, so it has great potential in the
treatment of breast cancer (Lewis and Veltmaat, 2004). Our previous study found
that curcumin inhibited the proliferation of breast cancer cells MDA-MB-231 and
MCF-7 in vitro and growth of xenograft in vivo. In this study, we found that
Gli1 overexpression in MDA-MB-231 adherent cells could promote cell
proliferation, invasion and migration, which were inhibited after curcumin and
GANT61 treatment. Moreover, curcumin inhibited the formation of mammospheres,
and down-regulated the expression of PTCH1,Gli1, Gli2 in Hh pathway in adherent
cells, and the expression of E-cadherin, vimentin of EMT genes and Gli1,Gli2,
SMO of Hh pathway in MDA-MB-231 mammospheres. In addition, further studies
demonstrated that curcumin could inhibit the entry of Gli1 into the nucleus.
These data suggested curcumin may inhibit invasion and metastasis of TN breast
cancer cells by targeting Gli1. Curcumin can inhibit the proliferation and
metastasis of TN breast cancercells, EMT and characteristics of breast cancer
stem cells.
Protective Effects of Curcumin in the Reproductive System
Natural Products and Human Diseases | January
2022
The well-known antioxidant natural product curcumin may have properties
which could diminish toxic effects. Curcumin has also shown some promise in the
cryoprotection of sperm samples through its antioxidant potential.
Curcumin
supplementation in pediatric patients: A systematic review of current clinical
evidence
Phytotherapy Research | January
2022
Clinical efficacy and safety of curcumin were assessed in children with
inflammatory and immune disorders (including asthma, inflammatory bowel disease
(IBD), and juvenile idiopathic arthritis (JIA)), metabolic disorders, autosomal
dominant polycystic kidney disease (ADPKD), cystic fibrosis (CF), tetralogy of
Fallot (TOF), and infectious diseases. Curcumin was administered in a wide
range of doses (45 mg–4,000 mg daily) and durations (2–48 weeks). Overall,
curcumin was well tolerated in all studies and improved the severity of
inflammatory and immune disorders and metabolic diseases. However, more studies
are needed to clarify the role of curcumin supplementation among children with
ADPKD, CF, TOF, and infectious diseases.
Curcumin Relieves Chronic
Unpredictable Mild Stress-Induced Depression-Like Behavior
Behavioral
Neurology | January
2022
Curcumin, the major active component extracted from the Chinese medicine
Curcuma longa, has been reported to possess neuroprotective effects.
Ccurcumin’s potential antidepressant-like effects have been highlighted in many
preclinical trials conducted on rats and mice models of depression. Curcumin
might be effective as adjunctive treatment in depressive disorders, indicating
the promising efficacy of curcumin depression. More and more studies have
discussed the potential mechanism of curcumin's antidepressant-like effects.
Our previous study found that curcumin could restore changes in proinflammatory
cytokines and the indolamine-2, 3-dioxygenase- (IDO-) kynurenine pathway in the
hippocampus of CUMS rats, which might ultimately contribute to its
antidepressant-like effect. Another study conducted by our teammates Liao et
al. suggested that the possible antidepressant-like effects of curcumin are
associated with oxidative stress and with changes in the activation of
erythroid-2-related factor 2 (Nrf2) in the brain. Moreover, Liao et al. found
that curcumin could reverse the decreased expression of BDNF. Other studies
have also indicated curcumin’s ability to increase BDNF levels. These studies
point strongly to an association between the antidepressant-like effects of
curcumin and the regulation of BDNF levels. Curcumin successfully attenuated
the abnormal behaviors induced by CUMS and effectively prevented CUMS-induced
reduction of PGC-1α, ERRα, FNDC5, and BDNF expressions. Curcumin also enhanced
PGC-1α and ERRα translocation from cytoplasm to nucleus. Furthermore, we found
that curcumin supplementation effectively promoted neurocyte proliferation and
suppressed neuronal apoptosis induced by CUMS. Of note, the PGC-1α inhibitor
SR18292 remarkably reversed the beneficial effects of curcumin on depressed
rats, indicating an important role of PGC-1α in the antidepressant-like effects
of curcumin. Collectively, our data evaluating the neuroprotective action of
curcumin in the CUMS rats highlights the involvement of the PGC-1α/FNDC5/BDNF
pathway in the antidepressant-like effects of curcumin.
Role of Curcumin in
Retinal Diseases—A review
Clinical and Experimental
Ophthalmology |
January
2022
Curcumin showed its pleiotropic effects in retinal diseases like diabetic
retinopathy by increasing anti-oxidant enzymes, upregulating HO-1, nrf2 and
reducing or inhibiting inflammatory mediators, growth factors and by inhibiting
proliferation and migration of retinal endothelial cells in a dose-dependent
manner in HRPC, HREC and ARPE-19 cells. In age-related macular degeneration,
curcumin acts by reducing ROS and inhibiting apoptosis inducing proteins and
cellular inflammatory genes and upregulating HO-1, thioredoxin and NQO1. In
retinitis pigmentosa, curcumin has been shown to delay structural defects of
P23H gene in P23H-rhodopsin transgenic rats. In proliferative
vitreoretinopathy, curcumin inhibited the action of EGF in a dose- and
time-dependent manner. In retinal ischemia reperfusion injury, curcumin
downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK. In retinoblastoma,
curcumin inhibits proliferation, migration and apoptosis of RBY79 and SO-RB50.
Curcumin has already proven its efficacy in inhibiting viral replication,
coagulation and cytokine storm in COVID era. Curcumin is a curcuminoid obtained
from turmeric (curcuma longa) that belongs to the Zingiberaceae family. They
belong to the group of phytocompounds that are biologically active molecules
obtained from plants with positive effects on health. Curcumin is a
bis-α,β-unsaturated β-diketone with the chemical name
1,7-bis-(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione and commonly called
diferuloylmethane, E100 (European code of food additives) or Natural Yellow 3.
Its chemical formula is C21H20O6 and molecular weight is 368.38 gm/mol. It has
two aromatic ring systems containing o-methoxy phenolic groups that are linked
with a seven-carbon linker consisting of α, β-unsaturated β-diketone moiety. It
also exists in two tautomeric forms, keto-enol and diketo tautomers. It is
present in keto-enol form in polar organic solvents, which is the predominant
form of tautomer. Cheng et al. studied the pharmacokinetics, toxicology and
biologically effective dose of curcumin in humans with high risk or
premalignant lesions. An initial dose of 500 mg once a day in empty stomach in
25 patients and the dose was increased to 1000, 2000, 4000, 8000 and 12,000 if
there was no toxicity ≥ grade 2 in at least 3 successive patients. No toxicity
was seen in doses up to 8000 mg. Curcumin showed no toxicity up to 8000 mg when
taken for 3 months.
The Effect of Curcumin Differs on
Individual Cognitive
Domains across Different Patient Populations: A Systematic Review and
Meta-Analysis Pharmaceuticals | December
2021
Curcumin is a polyphenol with strong antioxidant and anti-inflammatory
activity. It is also the primary active component of the Indian spice
turmeric
(Curcuma longa)and curry powders. Animal studies have also confirmed
that
curcumin has protective effects against cognitive decline, both in
aging rhesus
monkeys and in a streptozotocin-induced dementia rat model.
Specifically,
curcumin has been found to exhibit various selective effects, including
preventing atrophic change and cell loss in the prefrontal cortex
compared to
the hippocampus, decreasing neuroinflammation compared to promoting
neurogenesis, and more positive effects on working memory than on
recognition.
Following at least 8 weeks of nutritional supplementation, curcumin was
found
to improve working memory more than a placebo regimen. The results in
the
cognitive domain of processing speed were notable, with a borderline
p-value,
which may be significant if further trials are included. The protective
effect
of curcumin in the prefrontal cortex has also been demonstrated in
animal
models. Noorafshan et al. used three different neural damage rat
models,
including stress-induced, sulfite-induced, and sleep deprivation, and
found
that curcumin could prevent structural deterioration in neurons and
glial
cells, and could also counteract behavioral changes. This showed that
curcumin
had a direct protective effect on the prefrontal cortex and may explain
why
curcumin was able to effectively improve working memory, as observed in
our
meta-analysis. Turmeric Root and Its Bioactive Ingredient Curcumin
Effectively
Neutralize SARS-CoV-2 In Vitro Viruses | December
2021
Turmeric root, also known as Curcuma longa, is broadly used as a spice
widely
cultivated in Southeast Asia. The rhizome of Curcuma longa contains
several
structurally related curcuminoids. Sixty to 75% of the curcuminoid
content
consists of curcumin, also known as diferuloylmethane.As early as 1815,
the
bioactive ingredient curcumin was first isolated from turmeric root by
Vogel
and Pelletier. Curcumin reveals a broad spectrum of bioactivities such
as
antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor,
and
hepatoprotective activities. In addition to the antiviral activity,
curcumin
also exhibits anti-inflammatory effects. Randomized controlled trials
indicated
a significant downregulation of the human tumor necrosis factor alpha
(TNFα)
and interleukin 6 (IL-6) through curcumin. Curcumin Ameliorates the
Cd-Induced
Anxiety-like Behavior in Mice by Regulating Oxidative Stress and
Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the
Brain
Antioxidants | February 20 Curcumin is an active component of turmeric
(Curcuma
longa) which is widely used as a food additive in Indian cuisines and
Ayurvedic
medicines. Previously, researchers have reported the neuroprotective
effect of
curcumin in various neurodegenerative diseases. In our study on dim
light-induced neurodegeneration, we have shown the antioxidant effects
of
curcumin. Other researchers have also highlighted the anti-inflammatory
and
antioxidant effects of curcumin. Curcumin plays an effective role as a
natural
therapeutic drug to combat Cd-induced behavioral impairment by
regulating
oxidative stress and modulating inflammatory markers. Curcumin was
found to
improve the behavior of mice through reduction of prefrontal cortex
oxidative
stress and neuroinflammation as well as promotion of hippocampal
neurogenesis.
Therefore, curcumin supplementation in food and diet could reduce the
deleterious effect of heavy metal exposure. Antiviral Therapeutic
Potential of
Curcumin Molecules | December
2021
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione),
also
called diferuloylmethane, is the best example of a plant derivative
with an
enormous number of therapeutic properties, such as anti-oxidant,
anti-carcinogenic, anti-diabetic, anti-microbial, and antiviral
activity. In
traditional Indian Ayurvedic medicine, curcumin was widely applied in
many
therapeutic remedies. This compound is a natural polyphenolic substance
and an
active form of the traditional herb that is found in the rhizome of
Curcuma
longa (turmeric). Curcumin is the main molecule of the curcuminoids;
the
curcuminoids are comprised of curcumin (77%) as well as includes
bisdemethoxycurcumin (BDMC) (17%) and demethoxycurcumin (DMC) (6%). The
first
suggestion that curcumin had antiviral properties came in the 1990s,
with the
discovery that curcumin and curcumin boron complexes could inhibit the
human
immunodeficiency virus (HIV). Since then, numerous studies have found
that
curcumin has antiviral activity against a diverse set of viruses,
including
both RNA and DNA viruses, both enveloped and non-enveloped. Multiple
selected
studies were on different types of human viruses, including human
immunodeficiency virus (nine studies), hepatitis C virus (five
studies), human
cytomegalovirus (three studies), hepatitis B virus (four studies),
herpes
simplex viruses (four studies), dengue virus (four studies),
enterovirus 71
(two studies), human T lymphocyte virus (two studies), vesicular
stomatitis
virus (two studies), and respiratory syncytial virus (two studies).
There was
one study for viruses including zika and chikungunya, coronavirus, Rift
Valley
fever virus, human norovirus, coxsackievirus B3, Japanese encephalitis
virus,
and viral hemorrhagic septicemia virus. 27 studies showed that curcumin
reduced
the production of infectious particles in various infected cells in a
dose-dependent manner. Curcumin supplementation improves biomarkers of
oxidative stress and inflammation in conditions of obesity, type 2
diabetes and
nonalcoholic fatty liver disease (NAFLD) Food & Function | December
2021
A systematic search, through prominent online databases such as
MEDLINE,
Scopus, and Google Scholar was done focusing on randomized controlled
trials
(RCTs) reporting on the impact of curcumin supplementation in
individuals with
diverse metabolic complications, including obesity, type 2 diabetes and
nonalcoholic fatty liver disease. Summarized findings suggest that
curcumin
supplementation can significantly reduce blood glucose and
triglycerides
levels, including markers of liver function like alanine
aminotransferase (ALT)
and aspartate aminotransferase (AST) in patients with type 2 diabetes
and
nonalcoholic fatty liver disease. Importantly, this effect was
consistent with
the reduction of predominant markers of oxidative stress and
inflammation, such
as the levels of malonaldehyde (MDA), tumor necrosis factor-alpha
(TNF-α),
high sensitivity C-reactive protein (hs-CRP) and monocyte
chemoattractant
protein-1 (MCP-1) in these patients. RCTs suggest that curcumin is
beneficial
in ameliorating some metabolic complications. Curcumin as a Possible
Treatment
for COVID-19-Induced Anosmia and Ageusia Cureus | December
2021
Curcumin, the main component of the spice turmeric, is derived from the
rhizome
of the plant Curcuma longa. Beneficial effects of curcumin have been
reported
over centuries in the treatment of various ailments, from oncological
to
autoimmune disorders. Curcumin has been observed to block
pro-inflammatory
regulators and signaling pathways, including inhibiting nuclear factor
(NF)-kappa B activation and suppressing tumor necrosis factor-alpha
(TNF-α),
interleukin 1 beta (IL-1β), interleukin 6 (IL-6), monocyte chemotactic
protein-1 (MCP-1), prostaglandin E2, and cyclooxygenase-II, among
others.
Curcumin has been shown to bind and block the active site of Mpro, the
main
protease utilized by COVID-19 to produce proteins required for viral
replication from viral genomic RNA. Curcumin may also hinder the
formation of
the COVID-19 spike protein-ACE2 complex, preventing viral entry into
cells. The
anti-inflammatory action of curcumin may reduce nasal mucosal swelling.
Antioxidant effects of curcumin and neuroaging Genetics, Neurology,
Behavior,
and Diet | December
2021
Curcumin, a plant-based polyphenol, is known to scavenge free radicals
and
promote antioxidant activity. This chapter gives an overview of the
molecular
evidence by brain imaging studies is reviewed. There is preliminary
evidence
for curcumin improving memory and decreasing amyloid-β plaque
accumulation.
Consequently, curcumin has potential as a therapy in aging and
aging-related
disorders. Curcumin in Metabolic Health and Disease Nutrients |
December
2021
In recent years, epidemiological studies have suggested that metabolic
disorders are nutritionally dependent. A healthy diet that is rich in
polyphenols may be beneficial in the treatment of metabolic diseases
such as
polycystic ovary syndrome, metabolic syndrome, non-alcoholic fatty
liver
disease, cardiovascular disease, and, in particular, atherosclerosis.
Curcumin
is a polyphenol found in turmeric and has been reported to have
antioxidant,
anti-inflammatory, hepatoprotective, anti-atherosclerotic, and
antidiabetic
properties, among others. Targets of Curcumin against Colorectal Cancer
and the
Correlation with Tumor-Infiltrating Immune Cells Evidence-Based
Complementary
and Alternative Medicine | December
2021
In recent years, more and more studies have shown that curcumin has
great
potential in the treatment of colorectal cancer. Curcuma longa L.,
commonly
known as turmeric, is a rhizomatous herb of the ginger (Zingiberaceae)
family.
Curcumin is a lipophilic polyphenol compound extracted from the
Zingiberaceae
family, which lowers blood glucose and has anticancer,
anti-inflammation, and
antiaging effects. Howells et al. confirmed that curcumin is a safe and
well-tolerated adjuvant chemotherapy drug for folinic
acid/5-fluorouracil/oxaliplatin chemotherapy (FOLFOX) chemotherapy of
metastatic colorectal cancer. In a clinical trial, curcumin has been
proved to
promote the transformation of Treg cells to Th1 cells and enhance the
production of interferon-γ, supporting the antitumor effect of
curcumin in
colorectal cancer. The clinical efficacy of curcumin in the treatment
of
colorectal cancer has been recognized. Subsequent in vivo experiments
confirmed
that curcumin can reduce inflammation and colorectal cancer formation
in mouse
models. These research results showed that curcumin has many potential
effects
and has definite therapeutic effects on colorectal cancer . In
conclusion, in
this study, we identified the key targets of curcumin in colorectal
cancer
inhibition through the combination of network pharmacology, molecular
docking,
and tumor immune microenvironment analysis. The mechanism of action of
curcumin
is binding to AKT1, STAT3, and EGFR by hydrogen bond, hydrophobic
effect, and
Ï€-cation bond. The Functional Roles of Curcumin on Astrocytes in
Neurodegenerative Diseases Neuroimmunomodulation | December
2021
Curcumin is the main component of a yellow pigment, commonly called
diferuloylmethane, and is an active ingredient in the rhizome of the
herb
Curcuma longa that represents various biomedical applications. Curcumin
has
also been traditionally used for its medicinal benefits and wound
healing for
centuries. However, it was first applied as a drug to treat biliary
disease in
1937. Curcumin is a lipophilic polyphenol that is relatively stable in
the
acidic pH but decomposes in neutral-basic conditions. Curcumin contains
approximately 77% diferuloylmethane, 17% dimethoxycurcumin, and 6%
bisdemethoxycurcumin. Nowadays, curcumin (C21H20O6) has important roles
in the
attenuation of progression of some NDs because of its anti-amyloid and
anti-inflammatory agents. In addition, curcumin also has several
benefits, such
as being safe, inexpensive, and readily available polyphenol that can
cross the
blood brain barrier, thus attracting researchers to use it for treating
neurodegenerative diseases. Curcumin is an NF-κB inhibitor by
interrupting
ZO-1 expression and localization, MLC phosphorylation, and ROS
generation
inhibition, which constrains disruption of the BBB by Th17 cells.
Furthermore,
curcumin, through its NF-κB inhibitory effect, causes intestine
dendritic cell
differentiation into tolerogenic phenotypes, as well as naive T cells
to
differentiate into FoxP3+ regulatory T cells (intestine protective,
Treg).
Thus, curcumin can prevent colitis, due to its anti-inflammatory
function.
Curcumin has a critical role in transcription factor regulation.
Furthermore,
curcumin can regulate cytokines, adhesion molecules, protein kinases,
redox
status, and inflammation-associated enzymes. The pharmacological
activities of
curcumin are antimicrobial, anti-inflammatory, antioxidant, and
anticarcinogenic. It also exhibits potent immunoregulatory activities
that can
modulate the T cells, B cells, neutrophils, natural killer cells, and
macrophage activation and function. Curcumin has been shown to be
protective
for several cells, including astrocytes, neurons, microglia, and
different part
of the CNS such as hippocampal, mesencephalic, cortical, and spinal
cord. A
multiple sclerosis study showed that curcumin regulates T-cell
responses to
IL-12 by blocking IL-12 production, and IL-12 signaling, through
inhibiting
JAK-STAT signaling activation. Thus, it has been suggested that
curcumin could
be used for treating multiple sclerosis and other Th1-cell-mediated
inflammatory diseases. Furthermore, curcumin at high doses can directly
induce
T-cell apoptosis and inhibit T-cell proliferation through blocking of
the IL-2
signaling pathway, high-affinity IL-2R, and interfering with IL-2R
signaling.
These data indicate that curcumin has immunosuppressive effects on many
pathways. Thus, curcumin, through its proinflammatory cytokines,
decreases
TNF-α/β, IL-1, IL-6, and IL-8, and COX-2 provides a therapeutic
effect by
reducing inflammatory conditions. Curcumin can cross blood brain
barrier and,
by inhibiting proinflammatory cytokines, can regulate homeostasis of
the CNS.
The blood brain barrier has a crucial role in controlling the
homeostasis of
the brain microenvironment. Thus, because autoreactive T-cell
penetration plays
a key role in MS lesion development, the role of curcumin to protect
the blood
brain barrier could reduce the severity of MS. Curcumin also decreases
the
severity of chronic inflammatory diseases, such as rheumatoid
arthritis,
asthma, AD, and cancer. In phase II clinical trial, curcumin was used
orally in
a mouse model of colorectal cancer. It has been demonstrated that
curcumin can
prevent carcinogenesis through different mechanisms such as reduction
of
cyclooxygenases 1 and 2, 5-lipoxygenase, prostaglandin E2 (PGE2), and
5-hydroxyeicosatetraenoic acid production inhibition. Fortunately,
curcumin via
inhibition of NF-κB signaling pathways can improve the effects of some
chemotherapy drugs. For example, in the mouse model of human breast
cancer,
curcumin, in conjunction with paclitaxel, can slow breast cancer
progression
and metastasis to the lung. According to Alavez et al., curcumin,
through its
involvement in the regulation of protein homeostasis, can increase life
span in
several species. Curcumin, as a natural cost-effective product with
proven
pharmacological safety, has strong antioxidant and anti-inflammatory
effects
through modulating many cellular signaling pathways. Effect of curcumin
supplement or placebo in delayed onset muscle soreness: a systematic
review and
meta-analysis Bulletin of the National Research Centre | December
2021
Curcumin is a natural polyphenolic substance extracted from turmeric.
It has
various physiological effects, such as membrane protective effects and
tumor
necrotic factor TNF-α. This review suggested that persons who took
curcumin
supplement before exercise have pain score of about 1 score lower than
those
who took placebo in and post-exercise at 1, 2, 3 and 4 days. For
indirect
markers of muscle damage, the persons who took curcumin supplement
before
exercise have lower CK, TNF and IL score than those who took placebo.
From a
review of previous meta-analysis (Fang and Nasir
2021
), curcumin has efficacy in reducing CK serum levels and muscle
soreness index
among adults. Therefore, curcumin may be known as a priority EIMD
recovery
agent in interventions. To conclude, curcumin supplement has reduced
muscle
soreness and CK after exercise after 1, 2, 3, and 4 days when compared
to
placebo. Curcumin and Its Potential Impact on Microbiota Nutrients |
December
2021
Curcumin is a polyphenol substance isolated from the rhizome of
Zingiberaceae
and Araceae plants. It is a major active constituent of turmeric, a
common
Asian spice used as a dietary spice, food-coloring, as a herbal remedy,
and in
the beverage industries. Its bioactive components have been
investigated
recently [1,2]. Diferuloylmethane
(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), which is
commonly referred to as curcumin, has been shown to have activity at
the
cellular level, by signaling multiple molecules. In addition it exerts
antioxidant and anti-inflammatory properties. It may have many
therapeutic
effects, having exhibited antitumor, chemosensitizing,
hepatoprotective,
lipid-modifying, and neuroprotective effects. Piperine is a natural
alkaloid
that is found in black pepper intestine. As Hewlings and Kalman
emphasized in
their work, piperine has been associated with an increase in the
bioavailability of curcumin by 2000%. Polyphenols, such as
curcuminoids, are
naturally occurring bioactive compounds that, due to their antioxidant
abilities, play important roles in human nutrition. A substantial
amount of
promising evidence has indicated that curcumin may be capable of
preventing and
combating several metabolic syndromes, cancer, and obesity, and may
even play a
neuroprotective role. The metabolism of curcumin, which occurs in the
intestine, enhances its biological activity and, as a consequence,
biotransforms it into active metabolites, which may promote beneficial
effects
in the gut microbiota. Curcumin as a great contributor for the
treatment and
mitigation of colorectal cancer Experimental Gerontology | December
2021
This review mainly brings out the correlation between the curcumin and
its use
for the mitigation of colorectal cancer, the use of curcumin as a
chemotherapeutic agent, chemosensitizer, and in a combination and
synergistic
approach. The pharmacokinetics and pharmacodynamics properties of
curcumin and
its formulation approach helps in giving an idea to develop new
approaches for
the treatment of colorectal cancer using curcumin. Protective effect of
the
association of curcumin with piperine on prostatic lesions Food and
Chemical
Toxicology | December
2021
Curcumin plus piperine reduce malignant effects of BPA in prostate.
Inflammation provoked to BPA in the prostate was minimized by curcumin
and
piperine. Curcumin and piperine helped to minimize carcinogenesis.
Thus, these
phytochemicals minimize the deleterious action of BPA in prostatic
lobes,
especially when administered in association. The protective action of
curcumin
and piperine consumption is associated with weight loss,
anti-inflammatory
potential, and control of prostate epithelial cell homeostasis. The
effect of
Curcumin on multi-level immune checkpoint blockade and T cell
dysfunction in
head and neck cancer Phytomedicine | December
2021
This study evaluated the immune-modulating effects of Curcumin, which
has
well-established anti-cancer and chemopreventive properties, and its
long-term
safety as a phytochemical drug. We found that Curcumin decreased the
expression
of IC ligands such as PD-L1, PD-L2, and Galectin-9 in HNSCC, leading to
regulation of epithelial-to-mesenchymal transition-associated tumor
invasion.
Curcumin also effectively restored the ability of CD8+ cytotoxic T
cells to
lyse cancer cells. To evaluate the effect of Curcumin on the TME
further, the
4-NQO oral cancer model was used. Curcumin increased T-cell
proliferation,
tumor-infiltrating lymphocytes (TILs), and effector cytokines, and
decreased
the expression of PD-1, TIM-3, suppressive IC receptors and their
ligands
(PD-L1, PD-L2, and Galectin-9) in the TME, implying reinvigoration of
the
exhausted CD8+ T cells. In addition, Curcumin inhibited expression of
CD4+CD25+FoxP3+ Treg cells as well as PD-1 and TIM-3. These results
show that
Curcumin reinvigorates defective T cells via multiple (PD-1 and TIM-3)
and
multi-level (IC receptors and its ligands) IC axis suppression, thus
providing
a rationale to combine Curcumin with conventional targeted therapy or
ICB as a
multi-faceted approach for treating patients with HNSCC. The efficacy
of high
and low dose curcumin in knee osteoarthritis: A systematic review and
meta-analysis Complementary Therapies in Medicine | December
2021
Curcuminoids have been shown to possess multiple pharmacological
effects, such
as anti-inflammatory, anti-oxidative, anti-hyperlipidaemic, and
anti-platelet
effects, and also to relieve pain and reduce swelling. These properties
can be
attributed to curcumin acting as an inhibitor of the nuclear
factor-kappa β
(NF-κβ) pathway and a scavenger of reactive oxygen and nitrogen
species.
Curcuminoids are employed as adjunctive treatment for rheumatoid
arthritis,
degenerative neural disease, some cancers, and polycystic ovary
disease. Recent
randomized controlled trials) have revealed that curcumin has similar
effects
on pain relief NSAID may lower the NSAID dosage needed and reduce its
side
effects. Additionally, a recent study by Shep et al. reported less
rescue
medication use and fewer AEs in patients taking combined curcuminoid
and
diclofenac than in those taking diclofenac alone. Previous
meta-analyses have
shown that curcuminoids have beneficial effects on knee OA. Low- and
high-dose
curcuminoids have similar pain relief effects and adverse events in
knee OA.
Curcuminoids are associated with better pain relief than non-steroid
anti-inflammatory drugs. Effects of curcumin supplementation on
inflammatory
biomarkers in patients with Rheumatoid Arthritis and Ulcerative
colitis: A
systematic review and meta-analysis Complementary Therapies in Medicine
|
December
2021
Furthermore, more duration (> 8 weeks) and more dosage of curcumin
(more than
500 mg) is more related to reduction in ESR and CRP in adult patients
with
rheumatoid arthritis and ulcerative colitis in comparison with the
control
group. Curcumin prevents arsenic-induced carcinogenesis Chinese Medical
Journal
| December
2021
Curcumin, an acidic polyphenol compound has anti-inflammatory and
anti-tumor
effects. This natural chemopreventive agent, derived from rhizomes of
curcuma
species, provides antioxidant, anti-tumor, and anti-proliferative
efficacy.
Curcumin blocks cancer development by modulating multiple signaling
pathways.
Researchers have previously provided novel perceptions about the
mechanisms of
curcumin action in gastric cancer cell growth inhibition and its
therapeutic
strategies for gastric cancer control. Therefore, curcumin could be
considered
a novel therapeutic strategy to control gastric cancer cell growth.
Some
studies have emphasized the importance of curcumin in lung cancer
treatment and
the potential utility of curcumin as a method for improving therapeutic
outcome. Curcumin suppressed gemcitabine-resistant non-small cell lung
cancer
cell proliferation and induced apoptosis. Curcumin upregulated the
expression
of lncRNA-MEG3 and PTEN. Previous studies have also showed that
curcumin has
potential clinical application in gemcitabine-resistant non-small cell
lung
cancer treatment for its anti-tumor activity. Furthermore, curcumin
also showed
anti-inflammatory activity in the kidney. Another study identified
curcumin as
a common inhibitor of NLRP3 inflammasome activation and revealed that
curcumin
repressed inflammation. In view of the various advantages and
characteristics
of curcumin, its anti-tumor effect has attracted the attention of
researchers,
and has good application prospect in the prevention and treatment of
lung
cancer. Curcumin, a major yellow pigment and spice in turmeric and
curry, is a
powerful anti-cancer agent. The anti-tumor activities of curcumin
include
inhibition of tumor proliferation, angiogenesis, invasion, and
metastasis,
induction of tumor apoptosis, increase in chemotherapeutic sensitivity,
and
regulation of cell cycle and cancer stem cells, indicating that
curcumin has
strong therapeutic potential in modulating the progression of various
cancers.
Numerous studies have provided evidence that curcumin protects against
neurotoxicity, genotoxicity, and DNA damage in vivo and in vitro. To
date, more
than 100 clinical trials have been completed with curcumin, all of
which have
demonstrated its safety, tolerability, and effectiveness against
various
chronic diseases, including various cancers, diabetes, obesity, and
cardiovascular, pulmonary, neurological, and autoimmune diseases in
humans.
Curcumin may represent a useful supplement to improve chronic
inflammation and
prevent carcinogenic changes in patients. These studies have indicated
that
curcumin is a promising molecule for the prevention and treatment of
cancer. In
summary, in the first stage of As3+-induced carcinogenesis, curcumin
activates
Nrf2, decreases ROS, and induces autophagy in normal cells to prevent
As3+-induced cell transformation. In the second stage, curcumin
inhibits
constitutive expression of Nrf2 and promotion of ROS, apoptosis, and
inhibition
of angiogenesis in AsT cells to prevent tumorigenesis. Our results
suggest that
antioxidant natural compounds such as curcumin should be evaluated
further as
potential candidates for complementary therapy for As3+-induced
carcinogenesis.
Improvement of intestinal barrier function, gut microbiota, and
metabolic
endotoxemia in type 2 diabetes rats by curcumin Bioengineered |
November
2021
Curcumin is a natural polyphenol compound extracted from Curcuma tuber
and
Curcuma rhizome. It is believed to possess the ability of anti-tumor,
anti-inflammatory, antioxidant and anti-fibrosis effects. Studies have
shown
that curcumin could inhibit nuclear factor-κB (NF-κB) mediated
interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α) release
in db/db
diabetic mice, and further reduce the inflammatory reaction of mouse
liver. In
obese rats fed with high fat diet and obese mice with leptin gene
deficiency,
curcumin can inhibit the secretion of TNF and monocyte chemoattractant
protein-1 (MCP-1), improve inflammatory response, and reduce the levels
of
blood glucose and glycosylated hemoglobin. Clinical trials indicated
that oral
curcumin can improve the function of islet B cells in prediabetic
patients,
reduce insulin resistance, prevent progression to type 2 diabetes.
Therefore,
curcumin has good clinical application prospects. In this study, we
demonstrated that curcumin could improve the intestinal integrity in
the type 2
diabetes animal model, and promoted the expression of ZO-1 and
occludin. In
addition, the hyperglycemia and insulin resistance of type 2 diabetes
rats were
relieved by curcumin. The suppressive effect of curcumin on TLR4/NF-κB
was
also observed. Curcumin also improve the gut microbiota dysbiosis in
type 2
diabetes Some studies have indicated the protective role of curcumin in
intestinal barrier of diabetes. Their conclusions that curcumin could
improve
the intestinal barrier function are in line with our study. In this
study, we
found that the significant increase of LPS caused by HFD could be
remarkably
reduced by curcumin. We demonstrated that curcumin could improve the
intestinal
barrier function, gut microbiota, and metabolic endotoxemia in type 2
diabetes
rats. Therefore, curcumin might be a potential therapeutic agent for
the
treatment of type 2 diabetes. Neuroprotective Effects of Curcumin in
Methamphetamine-Induced Toxicity Molecules | November
2021
Curcumin, a natural polyphenol extracted from rhizome of the Curcuma
longa L,
has received great attention for its multiple potential health benefits
as well
as disease prevention. For instance, curcumin protects against toxic
agents
acting on the human body, including the nervous system. In detail,
curcumin
possesses, among others, strong effects as an autophagy activator. The
present
data provide evidence that curcumin counteracts the neurotoxic effects
induced
by methamphetamine by promoting autophagy. In recent years, curcumin
has
received great attention for its multiple potential health benefits as
well as
disease prevention. Curcumin has been explored for its multiple
biological
activities mostly focusing on autophagy activation, which is considered
to be
relevant to counteract various toxicants and disease conditions.
Curcumin
Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through
Multiple
Antiviral Mechanisms Molecules | November
2021
Curcumin, the main polyphenolic compound of turmeric, has attracted
significant
attention owing to its biological effects, such as anti- tumor,
anti-inflammatory, immunomodulating, antioxidant, antimicrobial, and
antiviral
activities; therefore, it has been proposed that curcumin may be a
potential
treatment against COVID-19. Notably, it has been observed that the
consumption
of curcuminoids leads to a significant reduction in circulating levels
of
C-reactive protein and decreases the expression of proinflammatory
cytokines,
including IL-1β, IL-6, IL-8, and TNF-α, demonstrating its
anti-inflammatory
capacity; it is important to highlight that this cytokines has been
correlated
with severe illness. Moreover, in macrophages, it has been observed
that
curcumin inhibits NLR family pyrin domain containing 3 (NLRP3)
inflammasome
activation, which plays a significant role in the development of
inflammatory
diseases. Additionally, curcumin exhibits its inhibitory activity
against the
replication of diverse viruses, such as dengue virus, hepatitis B
virus, zika
virus, influenza A virus, and chikungunya virus. Curcumin can exert
antiviral
effects directly on the viral particle or at different stages of the
replicative cycle by interacting with viral proteins or by modulating
cellular
processes or pathways crucial for viral replication. Specifically for
SARS-CoV-2, studies in silico (computer modeling) have reported that
curcumin
exhibits favorable binding affinities with the spike protein of the
virus, as
well as with its main cellular receptor, ACE2. These results suggest
that
curcumin has the ability to interfere with the entry of the virus into
the
cell. Furthermore, it has been reported that curcumin can affect the
expression
of other key molecules in the entry and decay of the virus, such as
TMPRS22,
Cat B, and L. The cumulative evidence suggests that curcumin could be
an
effective treatment strategy to complement the COVID-19 clinical
management.
Further, it has been persistently reported that curcumin has
anti-inflammatory
effects on in vivo models, such as atherosclerosis, multiple
sclerosisnd
inhibiting the production of pro-inflammatory cytokines and chemokines.
In this
sense, it has been shown that despite the low bioavailability of
curcumin, in
two models of chronic disease, this compound has anti-inflammatory
effects at
low doses, via IL-10 production. Moreover, the ability of curcumin to
alter the
inflammatory state through the modulation of its regulatory elements
can
prevent the onset of the cytokine storm. Evidence presented in this
article
suggests that curcumin represents a promising compound for developing
therapy
against SARS-CoV2. In this study, curcumin showed high cytotoxicity at
20
µg/mL in Vero E6 cells. In conclusion, curcumin showed in vitro
antiviral
activity against SARS-CoV-2, with different treatment strategies, which
suggest
the inhibition at different stages of the replicative cycle;
furthermore, these
effects seem to be independent of the virus strain/variant. This
antiviral
effect, together with the observed immunomodulatory properties,
suggests that
curcumin could be a promising compound for the treatment of COVID-19
patients.
Effects of Curcumin on Aging: Molecular Mechanisms and Experimental
Evidence
BioMed Research International | November
2021
Several lines of evidence highlighted a pleiotropic potential of
curcumin
towards several human diseases, such as malignancies, skin and
immune-related
disorders, cardiovascular diseases, pulmonary and renal fibrosis,
nonalcoholic
fatty liver disease (NAFLD), fatigue, neuropathic pain, bone and muscle
loss,
neurodegenerative disease, ocular diseases, leprosy, osteoporosis,
leishmaniosis, and HIV infection. Curcumin supplementation in human
melanoma
cells induces growth arrest and then apoptosis. Other studies also
reported
that curcumin may target oncogene expression, angiogenesis, invasion,
and
metastatic dissemination. Alongside with antitumorigenic activity,
curcumin was
also shown to induce antimicrobial, antioxidant, antiglycemic,
antiseptic, and
analgesic effects. With regard to inflammation, curcumin stimulates a
xenobiotic response with upregulation of defense genes and suppression
of
proinflammatory transcription factors and cytokines. Moreover, several
studies
indicated that curcumin and may be used as senolytic and
anti-inflammatory
agents for senescent cells. As reported by Banji et al.,
curcumin(40 mg/kg)
and piperine (12 mg/kg), especially when combined, counteract
D-gal-induced
senescence in male Wistar rats by targeting OS and lipofuscin
deposition,
finally leading to higher hippocampal volume and function with improved
spatial
memory. Aging and senescence are complex processes leading to organ
dysfunction. Despite being permanent, delaying the occurrence of these
processes is a reliable target, and curcumin might be a promising
candidate for
this purpose. Nevertheless, evidence from clinical studies on the
long-term
effects of curcumin on age-related pathological events remains largely
understudied. While several strategies to enhance the systemic
bioavailability
of curcumin have been suggested, the effects of long-term therapy with
such
bioavailability-boosted curcumin preparations is not fully known, and
increased
concentrations may even lead to opposite results. Pleiotropic benefits
of
curcumin supplementation involve the control of aging genes, OS, and
inflammation in both the vascular system and the central nervous
system.
Further studies are warranted to clarify the mechanisms of curcumin
function
for potential clinical application. Is Curcumin the Answer to Future
Chemotherapy Cocktail? Molecules | November
2021
Curcumin, also regarded as diferuloylmethane, is a yellow polyphenol
extracted
from the rhizome of the Curcuma longa (turmeric) plant, belonging to
the
Zingiberaceae family. Indigenous in south-eastern and southern tropical
Asia,
curcumin is traditionally applied for pain-relieving and wound healing
effects.
Commercial curcumin products contain approximately 77 % curcumin, 18 %
demethoxycurcumin and 5 % bisdemethoxycurcumin. Out of those
curcuminoids,
curcumin exhibits the most potent medicinal properties as compared to
demethoxycurcumin and bisdemethoxycurcumin. A growing body of evidence
has
demonstrated the benefits of curcumin in treating various diseases,
including
metabolic syndromes, hyperlipidaemia, inflammatory skin conditions,
neurodegeneration and rheumatoid arthritis. These clinical benefits are
attributed to the anti-inflammatory, anti-oxidant, and wound healing
activities
of curcumin. Moreover, curcumin can impede pathogenic infections by
exerting a
broad spectrum of anti-bacterial, anti-fungal and anti-viral
activities.
Enormous attention has given to the exploration of anticancer
properties in
curcumin. To date, curcumin has shown its anticancer benefits in
numerous
cancers such as breast cancer, colorectal cancer, lung cancer,
pancreatic
cancer and prostate cancer. In fact, these anticancer effects depicted
by
curcumin are highly associated with the modulation of several oncogenic
signalling pathways, which are essential in cancer development.
Curcumin
constrains these oncogenic signalling pathways and further limits the
downstream pro-tumorigenic activities. In vitro studies illustrated
that
curcumin treatment limited the proliferation and caused cell cycle
arrest in
HT-29 colon cancer cells and PLC/PRF/5 liver cancer cells via the
inhibition of
cyclin D1, with the downregulation of NF-κB and cyclooxygenase-2
(COX-2)
signalling. pathways and inhibition of MMP activities. Apart from
limiting the
expression of IAP family proteins, curcumin promotes the apoptosis of
cancer
cells by increasing the expression of Bax while downregulating the
expression
of Bcl-2 in various cancer cells. It has also been shown to be able to
abrogate
angiogenesis elicited by breast tumors via the suppression of VEGF.
Lately,
curcumin has gained a great deal of interest, attributed to its broad
range of
medicinal properties. Intriguingly, curcumin exhibited countless
anticancer
properties, such as limiting cancer cell proliferation, promoting tumor
cell
death and preventing metastasis. Besides, curcumin supplementation
greatly
relieves the patients from experiencing adverse effects caused by
conventional
therapies. Hence, these properties pose great advantages to the
development of
curcumin combination therapy for cancer treatment. This review focuses
on the
use of curcumin in combination therapy in various cancers. The evasive
mechanisms developed by cancer cells in response to cancer therapy are
discussed. Curcumin combination therapies used are reviewed in depth in
each
type of cancer in both preclinical and clinical studies. We also
addressed how
curcumin modulates a variety of molecular targets in cancer cells in
the
combination treatment, to provide an insight into the multitargeting
effects of
such treatment cocktails. Curcumin inhibits ovarian cancer progression
Journal
of Ovarian Research | November
2021
Curcumin is the active component of turmeric which has an
anti-cancerous
property in multiple cancers, including ovarian cancer. It can exhibit
the
anti-cancer role in ovarian cancer by decreasing tumorigenesis and
increasing
the efficiency of radio-chemotherapy. Curcumin suppressed ovarian
cancer cell
proliferation and promoted apoptosis. Circ-PLEKHM3 was downregulated in
ovarian
cancer, and its expression could be promoted by curcumin treatment.
Circ-PLEKHM3 overexpression exacerbated the effect of curcumin on
ovarian
cancer cell proliferation and apoptosis, as well as anti-tumor effect.
MiR-320a
was targeted by circ-PLEKHM3. The inhibition effect of circ-PLEKHM3
overexpression on cell proliferation and the enhancing effect on cell
apoptosis
could be reversed by miR-320a mimic. SMG1 was targeted by miR-320a, and
its
knockdown also reversed the regulation of miR-320a inhibitor on the
proliferation and apoptosis of ovarian cancer cells. In addition,
circ-PLEKHM3
could upregulate SMG1 expression via sponging miR-320a.
Anti-Inflammatory
Effects of Curcumin in the Inflammatory Diseases Drug Design,
Development and
Therapy | November
2021
Curcumin is a natural compound with great potential for disease
treatment. A
large number of studies have proved that curcumin has a variety of
biological
activities, among which anti-inflammatory effect is a significant
feature of
it. The anti-inflammatory effect of curcumin can effectively improve
the
symptoms of these diseases and is expected to be a candidate drug for
the
treatment of related diseases. Curcumin has anti-inflammatory,
anti-oxidant,
anti-tumor and other biological activities. The anti-inflammatory
properties of
curcumin are considered to be the basis of its various biological
activities
and play an important role in the treatment of diseases. Curcumin is
mainly
derived from the root tuber of Curcuma aromatica Salisb and the rhizome
of C.
longa L. (Turmeric) of Zingiberaceae. Turmeric is a common spice in
India and
has been described in Ayurveda, as a treatment for inflammatory
diseases. In
western herbalism, turmeric is primarily used as an anti-inflammatory
agent.3
Curcumin and curcuminoids, the active components of turmeric, are found
as
effective therapies over the years. Curcumin, demethoxycurcumin and
bisdemethoxycurcumin, these three compounds are called curcuminoids. In
addition, curcumin-containing dietary supplements are extremely
popular, and
there are many anti-oxidant and anti-inflammatory curcumin dietary
supplements
on the market.In conclusion, curcumin has good anti-inflammatory
properties,
and curcumin regulates NF-κB, MAPK, AP-1, JAK/STAT and other signaling
pathways, and inhibiting the production of inflammatory mediators.
Curcumin in
the treatment of IBD, arthritis, psoriasis, depression and
atherosclerosis and
other diseases, can reduce inflammatory response, effectively improve
symptoms,
play a role in the treatment of diseases. Now, the pharmacokinetics and
anti-inflammatory effects of curcumin have been improved to some extent
by the
structural modification and modification of curcumin, preparation
research and
drug combination therapy. Among them, curcumin dietary supplement or
adjuvant
drug has significant therapeutic effect, which is the most feasible way
for
curcumin application at present. Oral Curcumin With Piperine as
Adjuvant
Therapy for the Treatment of COVID-19 Frontiers in Pharmacology |
November
2021
Patients with mild, moderate, and severe symptoms who received
curcumin/piperine treatment showed early symptomatic recovery (fever,
cough,
sore throat, and breathlessness), less deterioration, fewer red flag
signs,
better ability to maintain oxygen saturation above 94% on room air, and
better
clinical outcomes compared to patients of the control group. Patients
received
curcumin-piperine capsules (three capsules/day; each capsules
containing 500 mg
curcumin plus 5 mg piperine; in total 1500 mg curcumin and 15 mg
piperine/daily). Furthermore, curcumin/piperine treatment appeared to
reduce
the duration of hospitalization in patients with moderate to severe
symptoms,
and fewer deaths were observed in the curcumin/piperine treatment
group.
Administration of oral curcumin with piperine as an adjuvant
symptomatic
therapy in COVID-19 treatment could substantially reduce morbidity and
mortality, and ease the logistical and supply-related burdens on the
healthcare
system. Curcumin could be a safe and natural therapeutic option to
prevent
Post-Covid thromboembolic events. Orally administered curcumin with
piperine
could play a multifaceted role in the treatment of COVID-19. The
anti-inflammatory and anti-thrombotic properties of curcumin could
expedite the
recovery of COVID-19 patients, and its antiviral, antibacterial, and
antifungal
properties could prevent superadded or secondary infections. Our
results
suggest that the use of orally administered curcumin with piperine as
adjuvant
therapy in COVID-19 treatment could substantially reduce morbidity and
mortality, reduces treatment costs, and decrease logistical burden
healthcare
systems. Dose-escalating studies have indicated the safety of curcumin
over 3
months. Hence, Curcumin can be a safe and natural therapeutic option to
prevent
Post-Covid thromboembolic events. Curcumin induces apoptosis through
caspase
dependent pathway in human colon carcinoma cells Molecular Biology
Reports |
November
2021
We investigated the apoptotic effects of curcumin in the colon
carcinoma cell
line SW480. The proportion of BrdU-stained cells in the control groups
were
58%, 57% and 61% and 28%, 27%, and 30% in the curcumin treatment groups
at 24,
48, and 72 h, respectively. The proportion of apoptotic cells was 28%,
29%, and
28% in the control groups and 59%, 61%, and 60% in the curcumin
treatment
groups at 24, 48, and 72 h, respectively. As expected, caspase-3
staining also
revealed a higher number of apoptotic cells in curcumin treatment
groups at 24,
48, and 72 h compared to controls. These results suggest that curcumin
may be a
potential protective or treatment agent against colon cancer. The
emerging role
of curcumin for improving vascular dysfunction Critical Reviews in Food
Science
and Nutrition | November
2021
Clinical intervention studies with curcumin have demonstrated
significant
improvements in endothelial function, arterial compliance, arterial
stiffness,
and other measures of vascular hemodynamics in young, middle-aged, old,
post-menopausal, healthy, diabetic, and obese individuals.
Mechanistically,
curcumin is believed to improve vascular function through its effects
on
inflammation, oxidative stress, nitric oxide bioavailability, and
structural
proteins of the artery. Current data give support for curcumin to be
administered for improvements in vascular health to individuals that
may or may
not be at risk for cardiovascular disease. This review briefly
summarizes the
techniques used for the establishment of vascular health and overviews
the
literature investigating the role of curcumin in the improvement of
vascular
health. Curcumin enhances drug sensitivity of gemcitabine-resistant
lung cancer
cells and inhibits metastasis Pharmazie International Journal of
Pharmaceutical
Sciences | November
2021
This study aimed to investigate the effects of curcumin on the
proliferation,
migration, and invasion of gemcitabine (GEM) resistant lung cancer A549
cells
(A549/GEM), and the potential mechanism. Curcumin and GEM can improve
the
sensitivity of A549/GEM to the GEM. Compared with the GEM, GEM plus
curcumin
significantly decreased the migration and invasion of A549/GEM cells.
The
expression levels of MMP9 , Vimentin, and N-cadherin were significantly
decreased, while the E-cadherin expression was increased. In vivo
experiments
showed a better therapeutic effect of GEM combined with curcumin than
that of
GEM alone, and the combination therapy did not cause more toxicity to
animals.
In summary, curcumin reversed GEM resistance and inhibited the EMT
process in
A549/GEM cells. GEM, combined with curcumin, is safe and more effective
in the
treatment of non-small cell lung cancer. Curcumin and Piperine in
COVID-19: A
Promising Duo to the Rescue? Biomarkers, New Treatments, and Vaccines
for
COVID-19 | October
2021
The combination of curcumin and piperine is a potential option for the
management of COVID-19 based on several mechanisms including antiviral,
anti-inflammatory, immunomodulatory, antifibrotic, and antioxidant
effects.
Here, we describe the probable mechanism of curcumin-piperine against
COVID-19.
Administration of curcumin-piperine combination appears as a potential
strategy
to counterbalance the pathophysiological features of COVID-19 including
inflammation. Curcumin for Parkinson's disease Cellular and Molecular
Biology |
October
2021
Parkinson's disease (PD) is one of the most prevalent neurodegenerative
disorders worldwide. Curcumin represents a promising bioactive compound
with
high therapeutic potential. Diverse studies in cellular and animal
models have
suggested that curcumin could be employed for the treatment of PD.
Current
clinical developments in curcumin-based therapeutics for cancer and
chronic
diseases Phytotherapy Research | October
2021
Curcumin, a natural compound extracted from the rhizomes of Curcuma
longa, has
been under intense scrutiny for its wide medicinal and biological
properties.
Curcumin is known to manifest antibacterial, antiinflammatory,
antioxidant,
antifungal, antineoplastic, antifungal, and proapoptotic effects. A
plethora of
literature has already established the immense promise of curcuminoids
in the
treatment and clinical management of various chronic diseases like
cancer,
cardiovascular, metabolic, neurological, inflammatory, and infectious
diseases.
To date, more than 230 clinical trials have opened investigations to
understand
the pharmacological aspects of curcumin in human systems. Counteracting
Action
of Curcumin on High Glucose-Induced Chemoresistance in Hepatic
Carcinoma Cells
Frontiers in Oncology | October
2021
Along with direct anticancer activity, curcumin hinders the onset of
chemoresistance. Among many, high glucose condition is a key driving
factor for
chemoresistance. Curcumin obviated the hyperglycemia-induced
modulations like
elevated glucose consumption, lactate production, and extracellular
acidification, and diminished nitric oxide and reactive oxygen species
(ROS)
production. Modulated molecular regulators are suggested to play a
crucial role
as curcumin pretreatment also prevented the onset of chemoresistance by
high
glucose. Curcumin alleviated the suppression of drug retention and
nuclear
condensation along with hindering the high glucose-induced alterations
in
transcription factors and signal transducers. Curcumin inhibited the
elevated
expression of these enzymes, transporters, and receptors in cancer
cells.
Curcumin also uplifted the SDH expression, which was inhibited in high
glucose
condition. Taken together, the findings of the present investigation
first time
demonstrate the ability of curcumin against high glucose-induced
chemoresistance, along with its molecular mechanism. This will have
implication
in therapeutic management of malignancies in diabetic conditions. The
effects
of curcumin supplementation on muscle damage, oxidative stress, and
inflammatory markers in healthy females International Journal of
Preventive
Medicine | October
2021
Given the reports of positive effects attributed to curcumin, many
studies have
investigated the antioxidant and antiinflammatory properties of
curcumin. A
previous report by Sahin et al. declared that curcumin administration
can
decrease muscle damage by regulating the nuclear factor-kappa B
(NF-κB) in
male Wister rats. In addition, the results of another study that
performed on
90 rats with poly cystic ovarian syndrome (PCOS) showed a significant
reduction
in C-reactive protein (CRP) levels in the curcumin-treated rats. In
healthy
young adult women, 8 weeks of curcumin supplementation yielded
significant
improvements in CRP, LDH, MDA, and VO2 max. In the present study, we
found that
8 weeks of curcumin administration attenuates MDA in females with
moderate
activity. In agreement with these findings, a previous study revealed
that
curcumin (1000 mg/day co-administered with piperine 10 mg/day)
supplementation
for 8 weeks led to a significant decrease in serum MDA and increase TAC
in
subjects with type 2 diabetes mellitus. Concordantly, 6-week
supplementation of
1500 mg/day curcumin elicited significant improvements in antioxidant
status
and a significant decrease in MDA concentrations in patients with knee
osteoarthritis. Curcumin, as an antioxidant agent, can increase
superoxide
dismutase level via inhibiting ROS-generating enzymes. In addition, it
can
increase serum activities of antioxidants. Another positive action of
curcumin
is related to scavenging properties to decrease oxidative damage.
Curcumin as a
great contributor for the treatment and mitigation of colorectal cancer
Experimental Gerontology | October
2021
This review mainly brings out the correlation between the curcumin and
its use
for the mitigation of colorectal cancer, the use of curcumin as a
chemotherapeutic agent, chemosensitizer, and in a combination and
synergistic
approach. The pharmacokinetics and pharmacodynamics properties of
curcumin and
its formulation approach helps in giving an idea to develop new
approaches for
the treatment of colorectal cancer using curcumin. Curcumin induces
apoptosis
and autophagy in human renal carcinoma cells Bioengineered | October
2021
Curcumin is a traditional Chinese herb that has been used for the
treatment of
various diseases. The compound has been particularly confirmed to have
anti-inflammatory, anti-cancer, anti-virus, and anti-oxidant
activities.
Curcumin shows less side effects, hence appropriate as a novel
anticancer drug.
Previous studies have shown that curcumin administration inhibited the
growth,
formation, invasion, and proliferation of prostate cancer. Curcumin
induces
apoptosis of RCC through AKT/mTOR pathway inhibition, suppresses the
TNF-a, IL6
and IL-8 pro-inflammatory cytokines. Further, curcumin down-regulates
Akt/mTOR
through upregulation of autophagy and finally, curcumin inhibits tumor
weight
and volume in vivo. Use of curcumin to target AKT/mTOR pathway could be
an
effective treatment alternative for renal cell carcinoma. Curcumin
attenuates
spatial memory impairment by anti-oxidative, anti-apoptosis, and
anti-inflammatory mechanism NeuroToxicology | October
2021
Curcumin treatment improves spatial memory impairment after
methamphetamine
neurotoxicity. Curcumin treatment has an antioxidant activity in
methamphetamine neurotoxicity. Curcumin treatment reduced caspase-3
activation
after methamphetamine neurotoxicity. Curcumin treatment has an
anti-inflammatory activity in methamphetamine neurotoxicity via
reducing of
TNFα. Curcumin treatment reduced astrogliosis after methamphetamine
neurotoxicity. Curcumin supplementation in the treatment of patients
with
cancer: a systematic review Brazilian Journal of Pharmaceutical
Sciences |
October
2021
Curcumin is a long-used phytochemical with a large number of biological
targets, for which anti-inflammatory, antioxidant, anti-tumor,
immunoregulatory, hepatoprotective, anti-ischemic, anti-dyspeptic,
anti-depressant, and analgesic effects have been determined (Amalraj et
al.,
2017
). Preclinical studies have reported curcumin as a potent epigenetic
regulator,
acting in the inhibition of deoxyribonucleic acid (DNA), DNA
methyltransferases
(DNMTs), regulation of modifications of histone acetyltransferases
(HATs) and
deacetylases (HDACs) and in regulation of micro ribonucleic acids
(miRNA)
(Boyanapalli et al.,
2015
; Remely et al.,
2015
). Studies conducted in vitro show that curcumin prevents the
degradation of
nuclear factor erythroid 2-related factor 2 (Nrf2), leading to an
increase in
antioxidant enzymes such as superoxide dismutase (SOD), catalase and
glutathione peroxidase (GPx). In addition, it balances the level of
these
enzymes and recovers reactive oxygen species (Rezaee et al.,
2017
; Sahebkar,
2013
). It was also shown to have an anti-inflammatory effect through
negative
regulation of several cytokines, such as tumor necrosis factor alpha
(TNF-α),
interleukins (IL-1, IL-6, IL-8, IL-12), monocyte chemoattractant
protein-1,
cyclooxygenase-2 activity (COX-2), lipoxygenase enzyme and inducible
nitric
oxide synthase (iNOS) (Aggarwal et al.,
2007
; Gupta et al.,
2013
). In vitro and in vivo investigations have also shown that curcumin
reduces
the inflammatory process by means of inflammatory transcription factors
such as
nuclear factor kappa (NF-kB), activator protein-1 (AP-1) and signal
transducer
and activator of transcription 3 (STAT3) (Panda et al.,
2017
; Imran et al.,
2016
). NF-ĸB and AP-1 also act as transcription factors that regulate the
expression of different genes which affect cellular processes, such as
proliferation and apoptosis. Curcumin also inhibited the expression of
urokinase plasminogen (uPA), focal adhesion kinase activity (FAK),
suppressed
expression of matrix metalloproteinases (MMPs), inhibited epidermal
growth
factor receptor (EGFR) activity, regulating tumor cell invasion and
metastasis
(Durgaprasad et al.,
2005
; Vadhan-Raj et al.,
2007
; Kim et al.,
2011
; Belcaro et al.,
2010
; Shokes et al.,
2005
; Adhvaryu et al.,
2008
; Biswas et al.,
2010
). Due to these therapeutic properties, curcumin exhibited activities
against
various types of cancer (Gupta et al.,
2013
; Dhillon et al.,
2008
; Golombick et al.,
2009
; Ide et al.,
2010
). The results of this study are based on those obtained in the
literature on
the effect of curcumin on the anti-inflammatory profile, on reducing
dermatitis, on PSA alteration and on anti-oxidant profile for a total
of 450
individuals, comprising 259 in the intervention group and 191 in the
control
group. Some studies have reported improvement in biochemical and
clinical
indicators, with limited adverse effects and good tolerance. The
clinical use
of curcumin on neurological disorders: An updated systematic review of
clinical
trials Phytotherapy Research | October
2021
Neuroprotective effects of curcumin have been shown in previous
studies. This
updated systematic review of clinical trials aimed to investigate the
effect of
curcumin on neurological disorders. Databases including PubMed, Scopus,
Web of
Science, and Google Scholar were systematically searched to identify
clinical
trials investigating the effects of curcumin/turmeric supplements
alone, or in
combination with other ingredients, on neurological diseases. Nineteen
studies
comprising 1,130 patients met the inclusion criteria. Generally,
intervention
and study outcomes were heterogeneous. In most of the studies, curcumin
had a
favorable effect on oxidative stress and inflammation. However, with
the
exception of AD, curcumin supplementation either alone, or in
combination with
other ingredients, had beneficial effects on clinical outcomes for the
other
aforementioned neurodegenerative diseases. For example, the frequency,
severity, and duration of migraine attacks, scores on the revised ALS
functional rating scale, and the occurrence of motor complications in
PD were
all significantly improved with curcumin supplementation either alone
or in
combination with other ingredients. Curcumin exhibited better potential
inhibition than Hydroxy-Chloroquine against COVID-19 Biological and
Medicinal
Chemistry | October
2021
According to present research results, Quercetin, Hispidulin,
Cirsimaritin,
Sulfasalazine, Artemisin and Curcumin exhibited better potential
inhibition
than Hydroxy-Chloroquine against COVID-19 main protease active site and
ACE2.
Targeting of cancer cell death mechanisms by curcumin: Implications to
cancer
therapy Basic & Clinical Pharmacology & Toxicology | October
2021
Curcumin (which originates from turmeric) is a hydrophobic polyphenol.
It is
one of the most famous anticancer and anti-inflammatory herbal agents.
Traditionally, curcumin was used for some diseases such as acne and
some
inflammation-related diseases like arthritis. Today, we know that
curcumin has
antioxidant and anti-inflammatory effects, which cause beneficial
effects on
the cardiac and neural systems and also has pharmacological effects on
some
diseases such as diabetes, Alzheimer, atherosclerosis, some immune
system
diseases and cancer. Curcumin has shown anticancer properties for
several types
of malignancies in both in vitro and in vivo studies. Gastrointestinal
system
malignancies, lung cancer, brain cancer cells, leukaemia, melanoma and
renal,
breast, prostate and pancreas cancers are some examples of inhibition
of
cancers by curcumin. Curcumin has also been shown to amplify the
anticancer
effects of chemotherapy drugs and radiotherapy. Although several agents
may
increase the therapeutic response of cancer cells to therapy, curcumin
has
shown interesting results for the protection of normal cells/tissues, a
property that can reduce side effects of cancer therapy. Curcumin has
been
shown to protect several organs such as the lung, gastrointestinal
system,
heart, liver, testis, bone marrow and skin against the toxic effects of
radiotherapy and chemotherapy. Curcumin as a natural agent has shown
interesting anticancer properties. It can prevent genomic instability
in normal
cells to prevent the development of cancer. Furthermore, it can
suppress tumour
growth at different stages through induction of cell death, suppression
of
cancer cells' migration, angiogenesis, and others. In this review, we
focused
on the mechanisms of cell death induction in tumours using curcumin.
Curcumin
is one of the most common herbal agents that has shown several
anticancer
properties. It can regulate immune system responses against cancer.
Furthermore, curcumin has been shown to potentiate cell death
signalling
pathways and attenuate survival signalling pathways in cancer cells.
The
knowledge of how curcumin induces cell death in cancers can improve
therapeutic
efficiency. In this review, the regulatory effects of curcumin on
different
cell death mechanisms and their signalling pathways will be discussed.
Furthermore, we explain how curcumin may potentiate the anticancer
effects of
other drugs or radiotherapy through modulation of apoptosis, mitotic
catastrophe, senescence, autophagy and ferroptosis. The Functional
Roles of
Curcumin on Astrocytes in Neurodegenerative Diseases
Neuroimmunomodulation |
October
2021
Curcumin is the main component of a yellow pigment, commonly called
diferuloylmethane, and is an active ingredient in the rhizome of the
herb
Curcuma longa that represents various biomedical applications. Curcumin
has
also been traditionally used for its medicinal benefits and wound
healing for
centuries. It was first applied as a drug to treat biliary disease in
1937.
Curcumin is a lipophilic polyphenol that is relatively stable in the
acidic pH
but decomposes in neutral-basic conditions. Curcumin contains
approximately 77%
diferuloylmethane, 17% dimethoxycurcumin, and 6% bisdemethoxycurcumin.
Nowadays, curcumin (C21H20O6) has important roles in the attenuation of
progression of some neurodegenerative diseases because of its
anti-amyloid and
anti-inflammatory agents. In addition, curcumin also has several
benefits, such
as being safe, inexpensive, and readily available polyphenol that can
cross the
blood-brain barrier, thus attracting researchers to use it for treating
neurodegenerative diseases. Curcumin is an NF-κB inhibitor by
interrupting
ZO-1 expression and localization, MLC phosphorylation, and ROS
generation
inhibition, which constrains disruption of the blood-brain barrierby
Th17
cells. Furthermore, curcumin, through its NF-κB inhibitory effect,
causes
intestine dendritic cell differentiation into tolerogenic phenotypes,
as well
as naive T cells to differentiate into FoxP3+ regulatory T cells
(intestine
protective, Treg). Thus, curcumin can prevent colitis, due to its
anti-inflammatory function. The pharmacological activities of curcumin
are
antimicrobial, anti-inflammatory, antioxidant, and anticarcinogenic. It
also
exhibits potent immunoregulatory activities that can modulate the T
cells, B
cells, neutrophils, natural killer cells, and macrophage activation and
function. Curcumin has been shown to be protective for several cells,
including
astrocytes, neurons, microglia, and different part of the CNS such as
hippocampal, mesencephalic, cortical, and spinal cord. An MS animal
study
showed that curcumin regulates T-cell responses to IL-12 by blocking
IL-12
production, and IL-12 signaling, through inhibiting JAK-STAT signaling
activation. Thus, it has been suggested that curcumin could be used for
treating MS and other Th1-cell-mediated inflammatory diseases.
Furthermore,
curcumin at high doses can directly induce T-cell apoptosis and inhibit
T-cell
proliferation through blocking of the IL-2 signaling pathway,
high-affinity
IL-2R, and interfering with IL-2R signaling. These data indicate that
curcumin
has immunosuppressive effects on many pathways. Thus, curcumin, through
its
proinflammatory cytokines, decreases TNF-α/β, IL-1, IL-6, and IL-8,
and COX-2
provides a therapeutic effect by reducing inflammatory conditions.
Curcumin can
cross blood-brain barrier and, by inhibiting proinflammatory cytokines,
can
regulate homeostasis of the CNS. The blood-brain barrier has a crucial
role in
controlling the homeostasis of the brain microenvironment. Thus,
because
autoreactive T-cell penetration plays a key role in MS lesion
development, the
role of curcumin to protect the blood-brain barrier could reduce the
severity
of MS. Curcumin also decreases the severity of chronic inflammatory
diseases,
such as rheumatoid arthritis, asthma, AD, and cancer. In phase II
clinical
trial, curcumin was used orally in a mouse model of colorectal cancer.
It has
been demonstrated that curcumin can prevent carcinogenesis through
different
mechanisms such as reduction of cyclooxygenases 1 and 2,
5-lipoxygenase,
prostaglandin E2 (PGE2), and 5-hydroxyeicosatetraenoic acid production
inhibition. Fortunately, curcumin via inhibition of NF-κB signaling
pathways
can improve the effects of some chemotherapy drugs. For example, in the
mouse
model of human breast cancer, curcumin, in conjunction with paclitaxel,
can
slow breast cancer progression and metastasis to the lung.
Unfortunately,
curcumin has several disadvantages in cancer treatment, including
inhibition of
some chemotherapy drug activities. For example, curcumin decreased
camptothecin-induced death in cultured breast cancer cells and
inhibited breast
tumor regression in mice. Furthermore, curcumin can also interfere with
colon
cancer treatment through the change in irinotecan absorption and
efficacy.
Curcumin is a valuable ingredient present in turmeric spice and has
several
essential roles, including those which are anticarcinogenic,
hepatoprotective,
thrombosuppressive, cardioprotective, anti-arthritic,
anti-inflammatory,
antioxidant, chemopreventive, chemotherapeutic, and anti-infectious.
Furthermore, curcumin can suppress inflammation; promote angiogenesis;
and
treat diabetes, pulmonary problems, and neurological dysfunction.
Pharmacological properties and underlying mechanisms of curcumin and
prospects
in medicinal potential Biomedicine & Pharmacotherapy | October
2021
The chemical structure of curcumin known as diferuloylmethane has been
elucidated in 1910, the first study on its biological activity as an
antibacterial agent according to the PubMed database has been published
in 1949
Nature journal and the first clinical trial has been reported in 1937
Lancet
journal. Until now, there are numerous in vitro, in vivo, and clinical
studies
that show it contained antioxidant, anti-inflammatory, anti-cancer,
anti-diabetic, and anti-viral infection. The major constituents of
curcuminoids
contain Dihydrocurcumin, Tetrahydrocurcumin, Curcumin,
Bis-demethoxycurcumin,
and Demethoxycurcumin from turmeric (C. longa L.) rhizome. The
beneficial
health properties and medicinal values of curcumin include its effect
on immune
modulation, cardiovascular protection, and neuroprotection. Previous
report,
the potential of turmeric as an antimicrobial, insecticidal,
larvicidal,
antimutagenic, radioprotector, and anticancer agent have validated in
cell-based studies. Numerous animal studies have found the latent of
turmeric
against proinflammatory diseases, obesity, diabetes, atherosclerosis,
cancer,
depression, and neurodegenerative diseases. Moreover, turmeric has
shown
efficacy against numerous human disorders including lupus nephritis,
irritable
bowel syndrome, acne, fibrosis, diabetes, and cancer in clinical trial.
Of
note, curcumin, major component of turmeric, is widely studied at the
preclinical level in various chronic illnesses that have been
extensively
reviewed in many papers including mechanistic insights . Of note
curcumin is an
important active ingredient in turmeric that exerts pharmacological
effects.
Current research has demonstrated that the pharmacological effects of
curcumin
include: anti-lipidemics, anti-diabetics, anti-tumor,
anti-inflammatory,
anti-fibrosis, anti-virus, anti-oxidation, and serve as free radical
scavengers. Curcumin suppresses the progression of gastric cancer Open
Life
Sciences | October
2021
Curcumin is a natural polyphenolic compound isolated from turmeric,
which has
lipid-lowering, anti-tumor, anti-inflammation, and anti-oxidation
effects.
Recently, studies have shown that curcumin can reduce the malignancy of
several
cancers, such as pancreatic cancer, retinoblastoma, osteosarcoma, and
bladder
cancer. Moreover, curcumin has also been reported to have an anti-tumor
effect
on gastric cancer. Nonetheless, the role and underlying mechanism of
curcumin
in gastric cancer have not been well recognized. We discovered that
curcumin
was able to inhibit gastric cancer cell growth and motility and induce
apoptosis by suppressing circ_0056618 and elevating miR-194-5p.
Previous
research have verified that curcumin exerts the anti-tumor effect
mainly by
repressing tumor cell proliferation and motility and facilitating
apoptosis.
For example, curcumin treatment restrained Rb cell proliferation,
invasion, and
migration and accelerated apoptosis. Curcumin suppressed the growth and
cell
cycle process and facilitated the apoptosis of gastric cancer cells. In
line
with these reports, we demonstrated that curcumin treatment restrained
cell
colony formation, migration, and invasion and accelerated cell cycle
arrest and
apoptosis in gastric cancer cells in vitro and blocked tumorigenesis of
gastric
cancer in vivo, indicating that curcumin might be a candidate agent for
gastric
cancer therapy. In summary, curcumin treatment could repress gastric
cancer
cell growth and metastasis and promote apoptosis partly by regulation
of
circ_0056618/miR-194-5p axis. The findings facilitated our
understanding on the
mechanism of curcumin in gastric cancer therapy and indicated that
curcumin
might be a potential therapeutic drug for gastric cancer . In addition,
accumulating evidence showed that curcumin might prevent gastric cancer
through
regulation of oncogenic pathways. The Therapeutic Effects of Curcumin
in Early
Septic Acute Kidney Injury: An Experimental Study Drug Design,
Development and
Therapy | October
2021
Curcumin, the major active component of Curcuma longa, was first
isolated in
1870 and widely used as spice, flavor, and colorant in daily life.12
Several
studies have evidenced the antioxidant, anti-inflammatory,
anticarcinogenic,
cardioprotective and nephroprotective effects of curcumin. The
protective
effects of curcumin on AKI are generally associated with its
bifunctional
antioxidant activity and anti-inflammatory activity Curcumin could
ameliorate
kidney disease with either acute or chronic nephritis, and reduce
activation of
the NF-κB, MAPK, AKT and pBAD pathways either systemically, or within
the
inflamed kidneys. In addition, previous research found that curcumin
could
improve renal function during ischemia-reperfusion induced acute kidney
injury,
which protected the tubular epithelium from injury by modulating
inflammatory
processes, oxidative stress, and apoptosis. In our study, we show that
curcumin
represents a new and promising effective treatment in S-AKI rat models.
Treatment with curcumin ameliorates renal functions, improves both
renal macro-
and microcirculatory flow, reduces inflammatory response and prevents
pathological changes in kidney. Curcumin may be a potential novel
therapeutic
agent for the prevention or reduction of S-AKI. Curcumin Reduces
Adipose Tissue
Inflammation and Alters Gut Microbiota in Diet-Induced Obese Male Mice
Molecuar
Nutrtion and Food Research | October
2021
Curcumin exerts protective metabolic effects in dietary obesity, in
part
through downregulation of adipose tissue inflammation, which may be
mediated by
alterations in composition of gut microbiota, and metabolism of
curcumin into
curcumin-o- glucuronide. New insights of structural activity
relationship of
curcumin and correlating their efficacy in anticancer studies American
Journal
of Cancer Research | October
2021
During the process of carcinogenesis at multiple stages, curcumin is
involved
in several mechanisms including (a) the inhibition of tumor initiation
(cytotoxic studies) (b) suppression of cellular proliferation
(antiproliferation studies) (c) the induction of apoptosis (d) the
inhibition
of angionesis and metastasis (e) the inhibition of tumor induced
immunosuppression. Analyzing the cytotoxic results, curcumin has shown
its
potency towards most of the cancer cell lines like Hela (Cervical
cancer),
HepG2 (Liver cancer), A549 (Adenocarcinoma human alveolar), MCF-7 and
MDA-MB-231 (Breast cancer), PC-3, RWEP-1 and DU145 (Prostate cancer),
SkoV3
(Ovarian cancer), A-431 (Epidermoid carcinoma), U-251, T98, U87, U87 MG
and U87
GBM (Glioblastoma), Panc-1 and BxPC3 (Pancreatic cancer), HT-29 and
HCT116
(Colon cancer), H1299 and H460 (Lung cancer), AGS (Gastric cancer),
HCT-15
(Colorectal adenocarcinoma), K562 (Chronic myelogenous).
Demethoxycurcumin
(DMC) and bisdemethoxycurcumin (BDMC) are naturally occurring
compounds, which
shows enhance potency against cancer cell lines in vitro and differ
from
curcumin in the position and number of hydroxyl and methoxy
substitution
pattern. The presence of methoxy and hydroxyl group in curcumin plays a
vital
role in deciding various biological activities as reported by various
research
groups. Curcumin is a naturally occurring compound which appears to be
significant clinical for applications in vitro as well as in vivo
studies. Many
of the research groups have been paying attention towards natural
products for
the development of anticancer drugs. Curcumin, Rosmarinic acid and
Chalcone are
the naturally occurring compounds, which are chemopreventive and
chemotherapeutic. The effects of curcumin as dietary supplement for
patients
with polycystic ovary syndrome Phytotherapy Research | October
2021
Compared with the control group, curcumin was associated with a
statistically
significant improvement in the glycemic control including fasting blood
glucose, insulin level, homeostasis model assessment of insulin
resistance, and
quantitative insulin sensitivity check index. The mean difference in
total
cholesterol was also statistically significant. This review concluded
that
among patients with PCOS, the use of curcumin demonstrated a
significant
difference from the control group for glycemic control. Those findings
suggest
that curcumin confers clinical benefits in patients with PCOS. Curcumin
as an
Adjuvant to Cancer Immunotherapy Frontiers in Oncology | September
2021
Turmeric, a common spice obtained from Curcuma longa of the
Zingiberacea
(Ginger) plant family, is the natural source of curcuminoids, a mixture
of
three different components, i.e., curcumin, demethoxycurcumin, and
bisdemethoxycurcumin. A major fraction of this compound mixture is
curcumin or
diferuloylmethane with 368.38 molecular weight. The crystalline
orange-yellow
powder is an active polyphenolic phytochemical and has been widely used
in
medicinal purposes for centuries in India and South Asia, due to its
nontoxic
but miraculous properties such as anti-oxidant, analgesic, antiseptic,
anti-inflammatory, and anti-cancer activity. Over time, curcumin has
been
considered as a potential anti-cancer molecule. Its potentialities have
been
recorded against the standard hallmarks of cancer such as continuous
proliferation, escaping apoptosis, continuous angiogenesis,
insensitivity to
growth inhibitors, tissue invasion, and metastasis. Finally, the
conclusion has
been drawn with the application of curcumin as a potential
immune-adjuvant,
which fearlessly could be used with immunotherapies for best outcomes.
Hence,
it is considered very interesting to envision the role of curcumin
concerning
cancer immunotherapies as an immunomodulator. Curcumin improves memory
deficits
by inhibiting HMGB1-RAGE/TLR4-NF-κB signalling pathway Journal of
Cellular and
Molecular Medicine | September
2021
Curcumin, extracted from turmeric rhizomes, is a Food and Drug
Administration-approved food additive in the curry spice turmeric. It
possesses
potent anti-inflammatory and antioxidant properties and is widely used
to treat
chronic inflammatory diseases, such as heart disease, cancer, metabolic
syndrome and various other degenerative diseases.It has therapeutic
potential
in AD models, both in vitro and in vivo. Curcumin is a natural
polyphenolic
product derived from the rhizome of Curcuma longa and has various
beneficial
properties, such as anti-inflammatory, antioxidant and antitumor
properties.
Here, we found that curcumin treatment effectively improved the
cognitive
performance of transgenic mice in the MWM and Y-maze, and our results
were
consistent with those of previous studies. In conclusion, this study
demonstrated that curcumin treatment significantly ameliorates
cognitive
impairment in aged APP/PS1 transgenic mice. The possible underlying
mechanism
might be associated with the accumulation of amyloid plaques,
activation of the
HMGB1-RAGE/TLR4-NF-κB signalling pathway, and astrocytes activated
during
neuroinflammation in APP/PS1 transgenic mice. These results suggest
that
curcumin treatment, as a food additive for long-term oral
administration, is an
effective therapeutic strategy for AD. Antimetastatic Effects of
Curcumin in
Oral and Gastrointestinal Cancers Frontiers in Pharmacology | September
2021
For centuries, curcumin has been widely used as a dietary spice, and
contemporary research studies have confirmed its efficacy in cancer
therapy.
Anticancer effects are the most pivotal properties of curcumin, which
affect
the different stages of cancer progression, including cancer cell
formation,
proliferation, and tumor invasion. According to extensive research,
curcumin
can suppress metastasis in GI cancers via regulating various signaling
pathways. Curcumin has a crucial function in metastasis prevention by
several
mechanisms, including preventing transcription factors as well as their
signaling pathways (e.g., NF-κB, STAT3, AP-1), multiple proteases
(e.g., MMPs,
uPA), inflammatory cytokines (e.g., CXCL1, IL-6, CXCL2, IL-8),
modulation of
miRNAs (e.g., miR181b, miR21), multiple protein kinases (e.g., FAK,
MAPKs), and
heat shock proteins (HLJ1). According to research, curcumin treatment
leads to
significant elevation in metastatic tumor cross-sectional volume (70%)
and zone
(46%). Curcumin may enhance LLC's metastatic growth in mice by
elevating the
concentration of VEGF, angiogenic factors, monocyte chemotactic
protein-1
(MCP-1), and IL-1β. In addition to the possible pharmaceutical effects
of
curcumin, the safety and relevant therapeutic dose should also be
established,
given reports on the side effects of curcumin in cancer therapy.
Curcumin a
polyphenolic extraction of Curcuma longa species, which is often termed
as
turmeric (Shafabakhsh et al.,
2019
; Ashrafizadeh et al.,
2020
). Curcumin had been used as a traditional Ayurvedic medicine due to
its
significant anti-inflammatory (Satoskar et al., 1986), antioxidant
(Masuda et
al.,
2001
), and antimicrobial (Negi et al., 1999) properties. Currently,
curcumin is
associated with powerful anticancer properties. Different animal
studies have
shown that curcumin has important roles in inhibiting primary
tumorigenesis in
numerous organs as metastatic sites, such as mammary glands (Inano et
al.,
1999) and gastrointestinal tract (Huang et al., 1994).It also
diminished the
vascular endothelial growth factor (VEGF) serum levels in mice models
of
hepatocellular carcinoma (Yoysungnoen et al.,
2006
). Curcumin suppresses inflammatory signaling in brain microglia The
Journal of
Immunology | September
2021
Curcumin is a major component of tumeric. It has been used as an Indian
medicine for centuries, and is currently commonly used as a spice for
flavor
and to impart a yellow color. Curcumin has recently received much
attention for
its anti-inflammatory, antioxidant, and antitumor activities. The
anti-inflammatory actions of curcumin seem to be closely related to the
suppression of proinflammatory cytokines and mediators of their release
such as
TNF-γ, IL-1β, and NOs. There are reports that curcumin inhibits
cytokine-mediated NF-κB activation by blocking a signal leading to
I-κB
kinase activity in intestinal epithelial and mouse fibroblast cells,
and also
suppresses phorbol ester-induced c-Jun/AP-1 activation. However, the
mechanisms
underlying interactions of curcumin with these signaling pathways are
poorly
understood. Recently, we have shown that JAK-STAT inflammatory
signaling
modulates glial activation. Thus, we examined whether curcumin inhibits
the
JAK-STAT pathways in activated microglia. Curcumin inhibits the
phosphorylation
of JAK1 and JAK2 via the increased phosphorylation of SHP-2 and its
association
with JAK1/2, thus attenuating inflammatory response. Our results show
that
curcumin acts via a novel anti-inflammatory mechanism and is also a
negative
regulator of the JAK-STAT pathway by the activation of SHP-2. Taken
together,
these data suggest curcumin suppresses JAK-STAT signaling via
activation of
SHP-2, thus attenuating inflammatory response of brain microglial
cells.
Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
Molecules |
September
2021
Curcumin is a natural dietary polyphenol extracted from Curcuma longa
Linn with
different biological and pharmacological properties including
antioxidant,
immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective,
nephro-protective, hepato-protective, anti-neoplastic, anti-rheumatic,
and
anti-aging. The chemical name of curcumin is
1,7-bis(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione with a
chemical
formula of C12H20O6; it is formed by two aromatic rings with a methaxy
phenolic
group, kinked with a linear carbon chain, with an α,β-unsatured
β-diketone
moiety. Curcumin, like other polyphenols, has pleiotropic activity.
Indeed, due
to its capacity to interact with many proteins, curcumin can induce
cellular
response to external stimuli. Moreover, curcumin up- and downregulates
different miRNA and takes part in epigenetic changes in cell. In our
view,
curcumin is one of the best candidates to achieve this goal with its
antiviral,
antinociceptive, anti-inflammatory, antipyretic, and antifatigue
proprieties.
It is important to highlight that Curcumin is devoid of any significant
toxicity in most of the preclinical as well as clinical investigations,
and few
investigations have reported negative effects of curcumin. In addition,
natural
products may be a safe, secure, and dependable source to find drugs
responsible
for controlling the current pandemic, and even if the beneficial
effects of
curcumin against SARS-CoV-2 have not yet been reported, curcumin has
some
useful clinical effects that could be effective to manage the symptoms
of the
infected patient with COVID-19. Curcumin in fact can modulate the
events of
SARS-CoV-2 cellular entry, their replication, and molecular cascade
manifesting
pathophysiological consequences of COVID-19. Due to its important and
healthy
proprieties, we think that dietary supplementation with curcumin could
be a
suitable approach to prevent a large panel of diseases and improve the
quality
of life. In this review, we have described the anti-aging potential of
curcumin
with particular regard to prevention and treatment of brain diseases,
in
different ways: (1) by acting on different target proteins, (2) by
inducing
antioxidant and anti-inflammatory events, (3) by modulating microglia
neuroprotection, and (4) by acting on telomerases to arrest cancer
progression.
Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and
Slows
In Vivo Growth of Liver Metastases in Rats Biomedicines | September
2021
Curcumin has shown an anti-tumor effect against liver implants from
colorectal
cancer, both in vitro and in vivo, in this experimental model. Curcumin
is a
well-known plant-derived polyphenol with a wide range of activities,
such as
antibacterial, anti-inflammatory, and hepatoprotective properties. In
vitro
studies with several cancer cell lines have proven curcumin to inhibit
proliferation, such as on MCF-7 human breast tumor cells. It has also
been
observed that curcumin can improve the efficacy of other therapies,
such as
Paclitaxel on rat glioma C6 cells, and of 5-FU and/or oxaliplatin in
BGC-823
human gastric cancer cell line or in HCT116 human colon cancer cells.
In this
cell line, it has been found that curcumin inhibits the cell cycle,
activates
p53 (only in p53+/+ cells) and p21, and triggers cellular senescence
(irreversible growth arrest of proliferating cells) through the
activation of
the lysosomal enzyme senescence-associated-β-galactosidase (SA-β-gal)
and the
upregulation of the p21 protein. Other studies have also shown that
curcumin-induced apoptosis is related to oxidative stress caused by the
production of superoxide anion, which contributes to p53-independent
cellular
cytotoxicity. These findings were further corroborated in other cell
lines
(COLO-205), showing that curcumin induces cytotoxicity and apoptosis in
a
dose-dependent manner. In addition, curcumin promotes the production of
reactive oxygen species and Ca2+, and induces the caspase-3 activity.
In in
vivo animal studies using cancer cells implants (most of them in
animals
lacking immune system), curcumin reduces the growth of the implants and
the
appearance of metastases. It has also been demonstrated that curcumin
reduces
tumor invasion and metastatic growth by, for example, reducing the
activity of
matrix metalloproteinases (MMPs) 2 and 9, or blocking nuclear
translocation of
nuclear factor kappa B (NFκB) by inhibiting the inhibitor of kappaB
kinase.
This molecular pathway is also involved in the prevention of liver
damage after
exposure to radiotherapy by regulating oxidative stress damage and
reducing the
accumulation of reactive oxygen species, which are well known to
contribute to
tumor progression by promoting cell transformation, proliferation, and
the
survival of tumor cells. Behavioral and morphological effects of
resveratrol
and curcumin in rats submitted to doxorubicin-induced cognitive
impairment
Research in Veterinary Science | September
2021
Curcumin prevented short and long-term memory deficits caused by
doxorubicin.
The Influence of Turmeric and Curcumin on Female Reproductive Processes
Planta
Medica | September
2021
The present review summarizes the available knowledge concerning the
action of
curcumin, the best-known polyphenol among the rhizomes of Curcumas, on
female
reproductive processes and their dysfunctions. Curcumin affects a
number of
physiological processes, including female reproduction (puberty,
reproductive
aging, ovarian follicullogenesis and oogenesis, and fecundity).
Curcumin can
affect these processes via changes in the release and reception of
pituitary
and ovarian hormones, growth factors and cytokines. Furthermore, it can
influence the response of ovarian cells to these substances and
external
environmental factors. Finally, curcumin can affect oxidative processes
within
the ovary and numerous intracellular signalling pathways related to
ovarian
cell proliferation and apoptosis. These effects suggest the
applicability of
curcumin for stimulation of female reproductive processes in vivo and
in vitro,
as well as for the prevention, mitigation, and treatment of various
reproductive disorders from ovarian insufficiency and infertility to
polycystic
ovarian syndrome and ovarian cancer. Curcumin Inhibits Replication of
Human
Parainfluenza Virus BioMed Research International | September
2021
Curcumin is a natural phenolic compound extracted from a plant turmeric
rhizome. It has a wide range of anti-inflammatory, antioxidant, and
antitumor
properties. Recent studies have found that curcumin has broad-spectrum
antiviral capabilities. Here, we identify a novel role for curcumin as
an
antiviral drug against HPIV3 infection through its ability to affect IB
formation and viral replication. This provides a theoretical basis for
research
and development of HPIV3 antiviral drugs, with implications for
parainfluenza
virus research and other similar viruses. Our studies found that
curcumin has a
significant antiviral effect on HPIV3 infection and has varying degrees
of
impact on multiple stages of the viral life cycle. Curcumin can disrupt
the
structural integrity of F-actin, downregulate the endogenous PI4KB
expression,
and interfere with the colocalization of PI4KB and IBs, thereby
hindering viral
IB formation and inhibiting viral replication. Mazumder discovered that
curcumin could inhibit HIV-1 integrase, thereby inhibiting HIV-1
infection, and
inhibit HCV replication by interfering with the Akt-SREBP-1 pathway.
Curcumin
can also interfere with binding of Zika and Chikungunya viruses to host
cells
to inhibit viral infection. To inhibit hepatitis B virus, curcumin can
downregulate the metabolic molecule PGC-1. Although curcumin
pretreatment does
not affect plaque formation of enterovirus 71 (EV71), curcumin
downregulates
PI4KB expression in cells and affects the in vitro replication of EV71.
Several
studies have shown that curcumin has antiviral ability against
enveloped and
nonenveloped viruses, and the antiviral mechanisms in different viruses
are
also diverse. Turmeric and Curcumin: From Traditional to Modern
Medicine
Studies on Biomarkers and New Targets in Aging Research | September
2021
The rhizome of turmeric (Curcuma longa L.) has been used as an herbal
medicine,
coloring agent, spice, and food additive for thousands of years in
different
parts of the world particularly in Asian countries. It has been used
for a
range of diseases in many traditional medical schools, including
Islamic
traditional medicine, Chinese traditional medicine, and Ayurveda. It
has been
used mainly for digestive problems, as a cardio-, hepato-, and
neuroprotective
agent as well as in many inflammatory conditions such as arthritis and
for
enhancing immune system. Curcumin, a diarylheptanoid derivative found
in
turmeric, has anti-inflammatory, antioxidant, and anticancer
properties;
controls obesity and metabolic problems; and improves memory and mood
disorders. These findings emphasize that most of the traditional
applications
of turmeric is due to the presence of its key constituent, curcumin.
According
to the traditional background of turmeric use and clinical values of
curcumin,
further preclinical studies for unstudied properties and clinical
studies with
larger sample sizes for confirmed activities are expected. Efficacy and
Safety
of Curcumin Supplement on Improvement of Insulin Resistance in People
with Type
2 Diabetes Mellitus Evidence-Based Complementary and Alternative
Medicine |
September
2021
Curcumin is a chemical component extracted from the rhizome of some
plants. It
has a series of effects such as blood lipid lowering, antitumor,
anti-inflammatory, and antioxidation and has been used as a food
flavoring
agent, preservative, and ancillary medication for some diseases (such
as heart
disease and tumors). In the treatment of diabetes, there is also
evidence to
support curcumin as a part of the diabetes treatment program. Based on
the
current evidence, curcumin may assist in improving insulin resistance,
glycemic
control, and decrease in TG and TC in patients with T2DM. Curcumin
functions as
an anti-inflammatory and antioxidant agent on arsenic-induced hepatic
and
kidney injury Environmental Toxicology | September
2021
As a plant polyphenol, curcumin is the most vital bioactive ingredient
of
turmeric and has a wide range of pharmacological activities. In the
present
study, we investigated the potential roles of curcumin against
arsenic-induced
liver and kidney dysfunctions in mice. Curcumin treatment (200 mg/kg)
not
only decreased the deposition of arsenic in liver and kidney, but also
relieved
the hepatic and nephritic biochemical indexes (Glutamic oxaloacetic
transaminase [AST], Alanine aminotransferase [ALT], albumin, and
creatinine)
altered by arsenic at doses of 10 and 25 mg/L via drinking water.
What's
more, curcumin exerted influences on the activities of myeloperoxidase
and on
the secretion of inflammatory cytokines in liver and kidney tissues. In
addition, the levels of mitogen-activated protein kinases (MAPKs) and
nuclear
factor kappa B (NF-κB) phosphorylation were declining while
NRF2-signaling
targets were increasing in mice liver and kidney by curcumin
administration. In
conclusion, our results here suggest that curcumin could exert both
anti-inflammatory and antioxidant functions on arsenic-induced hepatic
and
kidney injury by inhibiting MAPKs/NF-κB and activating Nrf2 pathways
cooperatively. Anti-Inflammatory Effect of Curcumin on the Mouse Model
of
Myocardial Infarction Mediators of Inflammation | September
2021
Curcumin, an active ingredient extracted from natural plants, has been
proven
to have many physiological effects, including hypolipidemic, antitumor,
anti-inflammatory, and antioxidation, and was used as treatment for
drug-resistant tuberculosis, etc. Importantly, previous studies have
shown that
curcumin promotes heart repair after myocardial infarction and improves
cardiac
dysfunction, as well as improving the therapeutic efficacy of heart
failure
after myocardial infarction, but the specific mechanism is imperfect.
In
addition, curcumin has been found to suppress inflammation by
inhibiting
macrophage infiltration, and it can also regulate macrophage
polarization. In
this study, we found that curcumin not only attenuated ventricular
remodeling
and inflammation after MI but also reduced M1 but increased M2
macrophage
activation in the MI mouse model. In addition, in vitro studies also
revealed
that some curcumin regulates the molecular mechanism of macrophage
polarization, which was regulated AMPK expression. All in all, our
research
enriches the mechanism of curcumin in the treatment of myocardial
infarction.
Effects of Curcumin against Influenza Using In Silico and In Vitro
Approaches
Pharmaceuticals | September
2021
Curcumin has attracted considerable research interest because of its
versatile
pharmacological properties, including anti-inflammatory, antiviral, and
anticancer effects. Previous studies have reported that curcumin
inhibits the
influenza virus by interfering with cellular signaling pathways,
including
Toll-like receptor and nuclear factor-κB pathways, and disrupting the
viral
envelope and liposomal membranes. Curcumin: Implications for the
Treatment of
Multiple Sclerosis Studies on Biomarkers and New Targets in Aging
Research |
September
2021
Curcumin is the active component of turmeric and a phenolic
phytochemical. This
phytochemical has anti-inflammatory properties and has been shown by
multiple
studies to downregulate NF-κB and its downstream gene targets
including
cyclooxygenase-2, tumor necrosis factor-α, interleukin-1, and
interleukin-6.
Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers
Frontiers in Pharmacology | August
2021
For centuries, curcumin has been widely used as a dietary spice, and
contemporary research studies have confirmed its efficacy in cancer
therapy.
Anticancer effects are the most pivotal properties of curcumin, which
affect
the different stages of cancer progression, including cancer cell
formation,
proliferation, and tumor invasion. According to extensive research,
curcumin
can suppress metastasis in GI cancers via regulating various signaling
pathways. Curcumin has a crucial function in metastasis prevention by
several
mechanisms, including preventing transcription factors as well as their
signaling pathways (e.g., NF-κB, STAT3, AP-1), multiple proteases
(e.g., MMPs,
uPA), inflammatory cytokines (e.g., CXCL1, IL-6, CXCL2, IL-8),
modulation of
miRNAs (e.g., miR181b, miR21), multiple protein kinases (e.g., FAK,
MAPKs), and
heat shock proteins (HLJ1). According to research, curcumin treatment
leads to
significant elevation in metastatic tumor cross-sectional volume (70%)
and zone
(46%). Curcumin may enhance LLC's metastatic growth in mice by
elevating the
concentration of VEGF, angiogenic factors, monocyte chemotactic
protein-1
(MCP-1), and IL-1β.Curcumin or
[(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione]
is a
polyphenolic extraction of Curcuma longa species. Curcumin had been
used as a
traditional Ayurvedic medicine due to its significant anti-inflammatory
(Satoskar et al., 1986), antioxidant (Masuda et al.,
2001
), and antimicrobial (Negi et al., 1999) properties. Currently,
curcumin is
associated with powerful anticancer properties. Different animal
studies have
shown that curcumin has important roles in inhibiting primary
tumorigenesis in
numerous organs as metastatic sites, such as mammary glands (Inano et
al.,
1999) and gastrointestinal tract (Huang et al., 1994). It also
diminished the
vascular endothelial growth factor (VEGF) serum levels in mice models
of
hepatocellular carcinoma (Yoysungnoen et al.,
2006
). Interleukin (IL)-1β and monocyte chemotactic protein-1 (MCP-1) are
critical
inflammatory cytokines in tumorigenesis. Accordingly, some studies
demonstrated
that these cytokines' expression levels reduced after curcumin
intervention
(Abe et al., 1999). Recent studies have also indicated that curcumin
can
modulate tumor immune responses and remodel the tumor immunosuppressive
microenvironment, indicating its potential in the immunotherapy of
cancer
(Mukherjee et al.,
2018
; Bahrami et al.,
2019
a; Pan et al.,
2019
). Curcumin has antimetastatic activities, modulating T cells, B cells,
macrophages, neutrophils, NK cells, dendritic cells and production of
cytokines
and chemokines. In addition, recent studies have shown that curcumin
exerts
immunosuppressive effects (Shafabakhsh et al.,
2019
). These findings showed that curcumin has crucial roles in the
inhibition of
angiogenesis and metastasis in GI cancers. Curcumin as Prospective
Anti-Aging
Natural Compound: Focus on Brain Molecules | August
2021
Curcumin is a natural dietary polyphenol extracted from Curcuma longa
Linn with
different biological and pharmacological properties including
antioxidant,
immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective,
nephro-protective, hepato-protective, anti-neoplastic, anti-rheumatic,
and
anti-aging. Curcumin, the yellow polyphenolic compound extracted from
Curcuma
longa species, is widely used in traditional Ayurvedic medicine to
prevent and
contrast many diseases, considering its antioxidant, immunomodulatory,
anti-inflammatory, anti-microbial, cardio-protective,
nephron-protective,
hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In
recent
years, the investigations of curcumin have been focused on its
application to
aging and age-associated diseases. Aging is a physiological process in
which
there is a decreasing of cellular function due to internal or external
stimuli.
Oxidative stress is one of the most important causes of aging and
age-related
diseases. Moreover, many age-related disorders such as cancer,
neuroinflammation, and infections are due to a low-grade chronic
systemic
inflammation. Curcumin acting on different proteins is able to contrast
both
oxidative stress than inflammation. In the brain, curcumin is able to
modulate
inflammation induced by microglia. Finally in brain tumors curcumin is
able to
reduce tumor growth by inhibition of telomerase activity. This review
emphasizes the anti-aging role of curcumin focusing on its mechanism to
counteract aging in the brain. Antioxidant effects of curcumin and
neuroaging
Factors Affecting Neurological Aging | August
2021
Curcumin, a plant-based polyphenol, is known to scavenge free radicals
and
promote antioxidant activity. evidenced by brain imaging studies is
reviewed.
Although there are limited published clinical trials, there is
preliminary
evidence for curcumin improving memory and decreasing amyloid-β plaque
accumulation. Consequently, curcumin has potential as a therapy in
aging and
aging-related disorders and further studies on its properties are
warranted.
Pleiotropic nature of curcumin in strategies to treat gastric cancer
Phytotherapy Research | August
2021
Curcumin, isolated from the rhizomes of Curcuma longa L. has several
medicinal
properties like antiinflammatory, antioxidant, antiapoptotic,
antitumor, and
antimetastatic. Such pleiotropic nature of curcumin impedes the
invasion and
proliferation of GC by targeting several oncogenic factors like p23,
human
epidermal factor receptor2 including Helicobacter pylori. The side
effect of
chemotherapy, that is, chemotherapeutic resistance and radiotherapy
could be
reduced combination therapy of curcumin. Moreover, the photodynamic
therapy of
curcumin destroys the cancer cells without affecting normal cells.
Targeting of
the tumor microenvironment by curcumin BioFactors | August
2021
Curcumin is a plant-derived agent that has shown interesting properties
for
cancer therapy. It has shown that not only directly inhibit the growth
of
cancer cells, but can also modulate the growth and activity of
immunosuppressant and tumor-promoting cells. In this review, we explain
how
curcumin modulates interactions within TME in favor of tumor treatment.
The
potential modulating effects of curcumin on the responses of cancer
cells to
treatment modalities such as immunotherapy will also be discussed.
Effect of
curcumin on proinflammatory cytokines: A meta-analysis of randomized
controlled
trials Cytokine | August
2021
Curcumin has the potential for lowering inflammation. There was a
significant
decrease in the serum levels of IL-1 and TNF-α compared to the placebo
group
following treatment. The dose-responses analysis indicated that
curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration
in a
non-linear model. Subgroup analysis according to duration and dose of
treatment
and target population revealed diverse outcomes. Curcumin could have a
beneficial effect in reducing the proinflammatory cytokines IL-1 and
TNF-α.
Antidiabetic Properties of Curcumin: Insights on New Mechanisms Studies
on
Biomarkers and New Targets in Aging Research | August
2021
Curcumin, a bioactive polyphenol derived from Curcuma longa L.,
exhibits
therapeutic effects against diabetes while only negligible adverse
effects have
been observed. Antioxidant and anti-inflammatory properties of curcumin
are the
main and well-recognized pharmacological effects that might explain its
antidiabetic effects. Additionally, curcumin may regulate novel
signaling
molecules and enzymes involved in the pathophysiology of diabetes,
including
glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters,
alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated
receptor gamma (PPARγ). Recent findings from in vitro and in vivo
studies on
novel signaling pathways involved in the potential beneficial effects
of
curcumin for the treatment of diabetes are discussed in this review.
Curcumin:
A Review of Its Effects on Epilepsy Studies on Biomarkers and New
Targets in
Aging Research | August
2021
Curcumin (diferuloylmethane) is a major component of Curcuma longa and
exhibits
various pharmacological effects, including anti-inflammatory,
antioxidant, and
immunoregulatory properties. Here, we have reviewed the literature
relating
specifically to the antiepileptic effects of curcumin. The evidence
suggests a
protective effect of curcumin in the control of epileptic seizures,
together
with a protective effect on the relief of memory impairment, which may
stem
from its influence on monoamine levels in the brain. Curcumin for the
Treatment
of Prostate Diseases: A Systematic Review of Clinical Trials Studies on
Biomarkers and New Targets in Aging Research | August
2021
Curcumin is a primary component of turmeric with several proven health
benefits
and is considered as a safe natural agent for both prevention and
treatment of
several diseases. It has been shown that this active compound of
turmeric has
several unique properties such as anti-tumour, anti-inflammatory,
antioxidant,
antithrombotic, chemosensitising and chemopreventive,
anti-atherosclerotic and
cardioprotective, lipid-modifying, antibacterial, antifungal,
antiviral,
analgesic, antidepressant and antirheumatic activities. Evidence
suggests that
curcumin has anticancer activity and, based on preclinical studies, it
might be
used to downregulate gene expression in prostate cancer cells. Also,
due to the
anti-inflammatory effects of curcumin, it has been suggested that this
bioactive compound might have a beneficial impact on BPH and other
inflammatory
prostate conditions. The main finding of this systematic review is that
curcumin supplementation alone or in combination with the other herbs
had some
favourable effects on prostate diseases without any considerable
adverse
effects. In particular, curcumin appeared to have anti-inflammatory
effects
which could offer some therapeutic effects and improve patient
outcomes. The
Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A
Systematic Review of Clinical Trials Studies on Biomarkers and New
Targets in
Aging Research | August
2021
Curcumin is one of the most studied hydrophobic polyphenols, derived
mainly
from Curcuma longa L. (turmeric). Curcumin has been widely and safely
used in
the treatment and prevention of various diseases. The potential
protective
mechanisms of curcumin have been claimed to be related to antioxidant,
anti-inflammatory, anti-microbial, neuroprotective, anti-tumor, and
immunomodulatory properties. Curcumin with anti-antioxidant,
anti-inflammatory,
and immunomodulatory properties might have beneficial effects on
Rheumatoid
Arthritis. Rheumatoid factor was significantly reduced after
consumption of
curcumin in all three relevant studies. None of the studies reported
serious
adverse effects with curcumin consumption. The present systematic
review
suggests that curcumin could be used as a safe agent to treat
Rheumatoid
Arthritis. Effect of curcumin on proinflammatory cytokines: A
meta-analysis of
randomized controlled trials Cytokine | August
2021
Curcumin has the potential for lowering inflammation. There was a
significant
decrease in the serum levels of IL-1 and TNF-α compared to the placebo
group
following treatment. The dose-responses analysis indicated that
curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration
in a
non-linear model. Subgroup analysis according to duration and dose of
treatment
and target population revealed diverse outcomes. Curcumin could have a
beneficial effect in reducing the proinflammatory cytokines IL-1 and
TNF-α. A
Systematic Review of the Clinical Use of Curcumin for the Treatment of
Osteoarthritis Studies on Biomarkers and New Targets in Aging Research |
August
2021
There is growing evidence that curcumin has anti-inflammatory
properties and
could be a potential therapeutic option for chronic inflammatory
diseases.
Hence, curcumin could potentially have a positive impact on
osteoarthritis
symptoms. There was a significant improvement in VAS and overall WOMAC
scores
with oral administration of various types of curcumin formulations with
no
severe adverse effects. In conclusion, different types of curcumin
compounds
may be beneficial as an alternative or complementary agent for the
management
of osteoarthritis. Neuroprotective Effects of Curcumin in Cerebral
Ischemia ACS
Chemical Neuroscience | August
2021
Curcumin, a polyphenol that is abundantly present in the rhizome of the
turmeric plant (Curcuma longa), has shown promising neuroprotective
effects in
animal models of neurodegenerative diseases, including cerebral
ischemia
postischemic brain including antioxidant, anti-inflammatory,
antiapoptotic,
vasculoprotective, and direct neuroprotective efficacies. Importantly,
neuroprotective effects of curcumin has been reported in both ischemic
and
hemorrhagic stroke models. A broad-spectrum neuroprotective efficacy of
curcumin suggested that curcumin can be an appealing therapeutic
strategy to
treat cerebral ischemia. 5 Science-Backed Health Benefits Of Curcumin
Forbes
Health | July
2021
Effect of moderate exercises and curcumin on hepatic transcriptional
factors
associated with lipid metabolism and steatosis in elderly male rat
Integrative/Functional Medicine | July
2021
Moderate aerobic exercise and curcumin alone or in combination
completely
masked this effect. Conclusion and implications: The findings revealed
dyslipidemia and liver steatosis related to aging might be partly
associated
with changes in hepatic transcriptional factors which can be
mitigatedmoderate
aerobic exercise and curcumin. Promising role of curcumin against viral
diseases emphasizing COVID-19 management Journal of Functional Foods |
July
2021
Curcumin has already acknowledged immense interest from both medical
and
scientific research because of its multifaceted activity. To date, the
promising influenza and HIV. The popular use of curcumin in research is
mainly
due to its pleiotropic properties including anti-inflammatory,
anti-oxidant and
anti-carcinogenic activities (Ahmad et al.,
2020
). Curcumin can inhibit the inflammatory mediators, oxidation
processes, and
oxidative stress thereby acts as an anti-inflammatory agent against
many
diseases (Wal et al.,
2019
). Praditya et al.
(2019
b) have shown curcumin as an anti-bacterial agent against several
strains of
Staphylococcus, Streptococcus, Helicobacter and Pseudomonas mainly by
growth
inhibition. They also reported the anti-fungal property of curcumin.
Different
studies identified the efficacy of curcumin against Human
immunodeficiency
virus (HIV), Herpes simplex virus (HSV), Hepatitis viruses etc.
(Praditya et
al.,
2019
a, Prasad and Tyagi,
2015
, Vitali et al.,
2020
). Although there are some controversies, the majority of the studies
support
the potential role of curcumin in inhibiting viral replication and
growth
inhibition (Mathew & Hsu,
2018
). Apart from these, long-term intake of curcumin can improve systolic
blood
pressure (Hadi et al.,
2019
), control obesity (JarzÄ…b & Kukula-Koch,
2019
), Type 2 Diabetes Mellitus (Pivari et al.,
2019
). Also, curcumin often acts as a cardio-protective, nephroprotective,
anti-neoplastic, hepato-protective and anti-rheumatic compound. While
the
entire world is putting efforts into the discovery of a vaccine against
coronavirus infection, the antiviral potential of curcumin against
SARS-CoV-2
shows a promising role in COVID-19 management. Since ancient time,
curcumin
possesses a multifaceted role in several disease management. As an
antiviral
agent, existing literature suggested that targeting viral lifecycle and
cellular responses are important strategies to combat viral infection.
The
present review emphasized the molecular mechanism of host-pathogen
interaction
and subsequent immune response in the host. In this background,
curcumin can
potentially inhibit the SARS-CoV-2 entry within human mainly by
blocking the
ACE2 ced multi-organ failure by constraining the inflammatory response
and
other cellular immune response. Curcumin inhibits the viability,
migration and
invasion of papillary thyroid cancer cells Experimental and Therapeutic
Medicine | July
2021
Curcumin is a main phenolic active compound in C. Longa Linn, and it
has
numerous pharmacological activities such as anti-inflammatory,
antibacterial
and, especially, anticancer activities. The anticancer effects of
curcumin are
due to targeting a wide range of cellular and molecular pathways
involved in
cancer pathogenesis. For example, curcumin has been revealed to induce
endoplasmic reticulum stress-associated apoptosis in human PTC cells
via
disruption of intracellular calcium homeostasis and to affect PTC cells
by
targeting the JAK/STAT3 signaling pathway. In summary, curcumin
suppressed the
cell viability, migration, invasion and EMT of TPC-1 cells. Moreover,
curcumin
treatment increased miR-301a-3p expression and inhibited STAT3
expression.
Overexpression of miR-301a-3p inhibited cell viability, migration,
invasion,
and EMT and the JAK/STAT signaling pathway by targeting STAT3, and
miR-301a-3p
inhibitors and STAT3 overexpression reversed the curcumin-induced cell
viability, migration, invasion and EMT of TPC-1 cells. Collectively,
curcumin
played an anticancer role in TPC-1 cells by regulating
miR-301a-3p/STAT3,
indicating that curcumin is a promising oncotherapeutic agent. These
findings
may provide a possible strategy for the clinical treatment of PTC.
Curcumin
modulates gut microbiota and improves renal function in rats with uric
acid
nephropathy Renal Failure | July
2021
Curcumin is a natural phenolic compound derived from the rhizome of the
plant
curcuma longa, and it is the main ingredient of turmeric. A large
number of
studies have confirmed that curcumin exerts a wide range of biological
effects,
including anti-tumor, anti-inflammatory, anti-oxidation, and
anti-fibrosis.
Based on the above pharmacological effects, there have been many animal
experiments and cellular experiments using curcumin to prevent and
treat
various kidney diseases in recent years, and even a few preliminary
reports on
the clinical application of curcumin in the treatment of renal
diseases.
Moreover, curcumin has also been shown to have the effects of
regulating
intestinal flora and improving gut barrier function in multiple
diseases, like
diabetes, ulcerative colitis, and colorectal cancer. Curcumin treatment
protected against the overgrowth of opportunistic pathogens in UAN,
including
Escherichia-Shigella and Bacteroides, and increased the could modulate
gut
microbiota, fortify the intestinal barrier, attenuate metabolic
endotoxemia,
and consequently protect the renal function. Anti-inflammatory effects
of
curcumin in acute lung injury International Immunopharmacology | July
2021
Curcumin reduces pyroptosis by inhibiting the expression of NLRP3. In
conclusion, curcumin has protective effect against acute lung injury.
It may
inhibit inflammatory process by inhibiting the activation of NLRP3
inflammasome-dependent pyroptosis through the up-regulation of SIRT1. A
Novel
Potent Sleep-Promoting Effect of Turmeric Molecular Nutrition &
Food Research |
June
2021
Turmeric extract has a sleep-promoting effect owing to reduction in
sleep
latency and enhancement of NREMS via H1R blockade; therefore, it could
be
useful in insomnia. Curcumin inhibits classical swine fever virus
replication
Microbiology | June
2021
Previous reports have shown that Curcumin inhibits many viruses,
including some
important members of different genera of Flaviviridae family (Japanese
encephalitis virus, dengue virus and hepatitis C virus). Curcumin
inhibited
classical swine fever virus replication by interfere lipid metabolism.
In
addition, our subsequent studies found that curcumin played an
antiviral role
by promoting the innate immune independent of NF-κB signaling pathway.
Taken
together, our finding highlights that curcumin is a potential candidate
drug
against classical swine fever virus for controlling classical swine
fever.
Curcumin reverses doxorubicin resistance in colon cancer cells at the
metabolic
level Journal of Pharmaceutical and Biomedical Analysis | June
2021
Natural product curcumin was demonstrated to have a variety of
pharmacological
effects, such as anti-tumor, anti-oxidation and anti-aging activities.
Curcumin
increased the cytotoxicity of Dox in SW620/Ad300 cells. Curcumin
reduced the
biosynthesis of polyamine and D-glutamine metabolism to reverse MDR.
Curcumin
inhibited the ODC expression, thererby decreasing the biosynthesis of
polyamine. Curcumin could be a promising multidrug-resitance reversal
agent for
cancer treatment. Curcumin suppresses the malignancy of non-small cell
lung
cancer Biomedicine & Pharmacotherapy | June
2021
Curcumin exerts a suppressive effect in tumor growth by acting as a
modulator
of multiple molecular targets. Curcumin, a traditional herbal medicine,
is
discovered in Curcuma longa. It is a polyphenol and has many
activities,
including controlling diabetes, improving brain function, oxidation,
anti-inflammatory, anti-tumor, and so on. It has been reported that
curcumin
plays an important role in various cell signal transduction by acting
as a
modulator of multiple molecular targets. Also, curcumin plays a
repressive role
in the advancement of NSCLC. Zhang et al. manifested that curcumin
synergistically constrained cell malignancy. Furthermore, curcumin
played an
anti-tumor activity in NSCLC cells. Curcumin has attracted the
attention of
scientific researchers all over the world because of its anti-cancer
potential.
Accumulated studies have revealed that curcumin can target cell
signaling
pathways related to cancer development. For example, curcumin elevated
miR-99a
expression in retinoblastoma cells, thereby blocking the JAK/STAT
pathway and
repressed cell malignancy. Moreover, curcumin inhibited the
proliferation of
glioblastoma cells via blocking the AKT/mTOR pathway. Recent research
revealed
that curcumin elevated nasopharyngeal cancer radio-sensitization
through
regulating the circRNA/miR/mRNA network. Herein, we discovered that
curcumin
curbed the malignancy of NSCLC cells through repressing the
circ-PRKCA/miR-384/ITGB1 pathway. Curcumin and rheumatoid arthritis: A
systematic review of literature International Journal of Clinical
Practice |
June
2021
Curcumin is a natural polyphenol and the main compound from the rhizome
of
Turmeric (Curcuma longa) and other Curcuma species. It has been widely
used for
different medical purposes, such as improvement of pain and
inflammatory
conditions in various diseases. Most studies have shown the curative
effects of
curcumin on clinical and inflammatory parameters of RA and reported
different
mechanisms; inhibition of mitogen-activated protein kinase family,
extracellular signal-regulated protein kinase, activator protein-1 and
nuclear
factor kappa B are the main mechanisms associated with the
anti-inflammatory
function of curcumin in RA. The results of the only human study showed
that
curcumin significantly improved morning stiffness, walking time and
joint
swelling. In conclusion, curcumin seems to be useful, and it is
recommended
that more human studies be performed to approve the cellular and animal
results
and determine the effective and optimal doses of curcumin on RA
patients. The
efficacy and safety of Curcuma longa Extract and curcumin supplements
on
osteoarthritis: a systematic review and meta-analysis Bioscience
Reports | June
2021
Curcuma longa Extract and curcumin may be a safer and effective
supplement for
osteoarthritis patients. It is recommended to use Curcuma longa Extract
and
curcumin supplement for osteoarthritis patients for more than 12 weeks.
Curcumin is a natural active oxygen scavenger and active nitrogen
provider, and
has been proven to be effective in treating pain caused by arthritis
and
osteoarthritis. Compared with NSAIDs, Curcuma longa Extract and
curcumin have
similar effects on joint pain, function and stiffness. However, the
incidence
of adverse events in Curcuma longa Extract and curcumin was lower.
Compared
with the NSAIDs group, Curcuma longa Extract and curcumin+NSAIDs can
also
relieve pain (decrease the VAS and WOMAC score-pain), improve the joint
function (decrease the WOMAC score-function), and improve the joint
stiffness
(decrease the WOMAC score-stiffness); in terms of adverse events, the
addition
of Curcuma longa Extract and curcumin to NSAIDs did not increase
adverse
events. Our meta-analysis also showed that Curcuma longa Extract and
curcumin
can improve oxidative stress in patients with osteoarthritis. Our
meta-analysis
shows that the combination of Curcumin and NSAIDs does not increase the
occurrence of adverse events and has better efficacy. This is a
promising
result, because adding Curcumin supplementation in the case of using
NSAIDs may
increase the efficacy and perhaps reduce the dosage of NSAIDs. Study
presents
evidence supporting the use of curcumin as alternative treatment for
kidney
fibrosis The Gary Null Show | June
2021
Curcumin is an effective alternative treatment for renal fibrosis
According to
several animal studies, curcumin can protect the kidneys by preventing
the
development of renal fibrosis. The researchers found that curcumin
(3.125 and
25?micromol/L) effectively promoted HKC proliferation. After 72 hours
of
incubating HKCs with TGF-B1 and curcumin, curcumin caused the cells to
maintain
epithelial morphology in a dose-dependent manner. It also decreased the
expression of EMT-related proteins, such as vimentin, a-SMA and FSP1,
and
increased the expression of E-cadherin and cytokeratin. In addition,
the
researchers noted that curcumin reduced Akt, mTOR and P70S6K
phosphorylation,
which effectively suppressed the activation of the Akt/mTOR pathway in
HKCs.
Based on these findings, the researchers concluded that curcumin is an
effective alternative treatment for renal fibrosis because it can
promote HKC
proliferation and stop EMT by inhibiting the activation of the Akt/mTOR
pathway
activity. The Role of Curcumin in Gastrointestinal Cancers Advances in
Experimental Medicine and Biology | June
2021
Curcumin has been used in combinations with many anti-tumor drugs to
increase
their anticarcinogenic properties. Taken together, curcumin falls
within the
category of plant-derived substances capable of preventing or treating
gastrointestinal cancers. Curcumin is a natural compound derived from
turmeric
with a wide range of biological activities. Several in vitro and in
vivo
studies have investigated the effects of curcumin on gastrointestinal
cancers.
In the current review, we aimed to provide an updated summary on the
recent
findings regarding the beneficial effects of curcumin on different
gastrointestinal cancers in the recent curcumin can inhibit cell growth
through
cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis
and
autophagy by interacting with multiple molecular targets. In vivo
studies
performed in various animal models have confirmed mainly the
chemopreventive
effects of curcumin. Effect of eight-week curcumin supplementation with
endurance training on glycemic indexes in middle age women with type 2
diabetes
Diabetes & Metabolic Syndrome: Clinical Research & Reviews |
June
2021
Eight weeks of curcumin supplementation and endurance training, whether
done
separately or simultaneously, significantly reduced fasting blood
glucose,
glycosylated hemoglobin and serum insulin levels (P < 0.05). The
combination of
curcumin supplementation and endurance training compared to the other
two
interventions caused a significant further decrease in these glycemic
indexes
(P < 0.05). The findings of this study showed that eight weeks of
curcumin
supplementation and endurance training helped each other in improving
the
glycemic indexes of women with type 2 diabetes. The protective effect
of
curcumin on rats with DSS-induced ulcerative colitis and its mechanisms
Research Square | May
2021
Curcumin is a traditional Chinese herbal medicine that is used for
anti-inflammation in China and Southeast Asia. Curcumin has
antioxidant,
anti-inflammatory, anticancer and antiapoptotic properties. The
advantages of
curcumin, such as few adverse reactions, high levels of safety, and
good
compliance, have attracted the attention of many researchers. Studies
have
shown that curcumin can reduce airway inflammation by regulating the
balance of
Treg/Th17 cells in asthma models. In IBD model mice with genetic
deletion of
IL-10, an emulsion of curcumin in sodium carboxymethyl cellulose
induced
anti-inflammatory effects. The curcumin group exhibited significantly
reduced
DAI scores and improvements in histopathological damage. The expression
of
CD4+IL-17+ Th17 cells was significantly lower and the expression of
CD4+CD25+Foxp3+ Treg cells was significantly higher in the curcumin
group than
in the DSS group. Curcumin may be a new and effective treatment for IBD
by
regulating the balance of Treg/Th17 cells and the expression of IL-10
and
IL-17A. The present study showed that compared with those of IBD rats
in the
DSS group, IL-10 levels of IBD rats in the curcumin group were
significantly
higher. Therefore, the protective effect of curcumin was related to
IL-10. In
summary, curcumin attenuated colonic tissue damage in DSS-induced UC
rats by
improving the Treg/Th17 cell balance and influencing the expression of
inflammatory cytokines. Curcumin promotes cell cycle arrest and
apoptosis of
acute myeloid leukemia cells Oncology Reports | May
2021
Curcumin, a phytochemical from rhizomes of the plant Curcuma longa, has
been
reported to exert potential anticancer properties in various cancer
types,
including acute myeloid leukemia (AML). Collectively, the present study
demonstrated that curcumin exerted anti-AML roles by inactivating AKT
and these
findings may aid in the treatment of AML. Effects of curcumin
supplementation
on sport and physical exercise Critical Reviews in Food Science and
Nutrition |
May
2021
Curcumin supplementation displayed significant reductionof inflammation
derived
from the physical exercise. After curcumin supplementation there was a
significantimprovement in some aspects of muscle recovery and
performance in
exercise. Curcumin has recently drawn worldwide attention ofresearchers
(Salehi
et
al.2019
), who conducted studies thatindicated that its medicinal properties
are
associated withthe reduction of pain (Karlapudi et
al.2018
; Sun et
al.2018
), anti-inflammatory effects (Ghandadi and
Sahebkar2017
; Mollazadeh et
al.2019
), besides prevention and treat-ment of cardiovascular (Li et
al.2020
; Momtazi-Borojeniet
al.2019
) and gastrointestinal (GI) diseases (Ghosh et
al.2018
; Mazieiro et
al.2018
), cancer (Kunnumakkara et
al.2017
; Mizumoto et
al.2019
; Talib et
al.2018
) and otherchronic diseases (Kunwar and
Priyadarsini2016
; Prasadet
al.2014
; Salehi et
al.2019
; Sharan Patel et
al.2019
).Also, studies that employed animal models reportedpositive results of
curcumin supplementation for physicalactivity and sport performance
(Huang et
al.2015
), thussupporting muscle recovery and reduction of inflammation(Davis
et
al.2007
), improvement of mitochondrial biogen-esis (Ray Hamidie et
al.2015
), reduction of oxidative stress(Kawanishi et
al.2013
), prevention of fatigue and muscledamage (Huang et
al.2015
; Sahin et
al.2016
). The evidences presented indicate that cur-cumin supplementation in
human
beings is likely safe andbeneficial for sport and physical activity,
due to the
reduction of inflammation and oxidative stress, reduction of painand
muscle
damage, improved muscle recovery, sport performance, psychological and
physiological responses (thermal and cardiovascular) during training,
as well
as the GI function. Role of Curcumin in Regulating Long Noncoding RNA
Expression in Cancer Advances in Experimental Medicine and Biology |
May
2021
Phytochemicals are various compounds produced by plants. There is
growing
evidence on their potential health effects. Some of these compounds are
considered as traditional medicines and used as painkillers,
anti-inflammatory
agents, and for other applications. One of these phytochemicals is
curumin, a
natural polyphenol derived from the turmeric plant (Curcuma longa L.).
Curcumin
is widely used as a food coloring, preservative and condiment. It has
also been
shown to have antioxidative and anti-inflammatory effects. Moreover,
there is
growing evidence that curcumin alters long noncoding RNAs (lncRNAs) in
many
kinds of cancer. These noncoding RNAs can cause epigenetic modulation
in the
expression of several genes. This study reviews reports of curcumin
effects on
lncRNAs in lung, prostate, colorectal, breast, pancreatic, renal,
gastric, and
ovarian cancers. The effect of curcumin and zinc co-supplementation on
glycemic
parameters in overweight or obese prediabetic subjects Phytotherapy
Research |
May
2021
Curcumin and zinc have been studied as an antioxidant,
antiinflammatory, and
antidiabetic agents. Based on these results, zinc and curcumin
supplementation
exerted a beneficial effect on several key glycemic parameters.
Curcumin
Reduces Neuroinflammation and Improves the Impairments of Anesthetics
on
Learning and Memory Neuroimmunomodulation | May
2021
Curcumin has a protective effect on ISO-induced cognitive dysfunction,
which
may be achieved by regulating the expression of miR-181a-5p. Curcumin: A
small
molecule with big functionality against amyloid aggregation in
neurodegenerative diseases and type 2 diabetes BioFactors | May
2021
we discuss clinical trials in which curcumin is used as a therapeutic
agent for
the treatment of diseases linking to protein aggregates.
Anti-Inflammatory
Effect of Curcumin on Rheumatoid Arthritis Pharmaceuticals | May
2021
Recent studies reveal that curcumin, a natural dietary
anti-inflammatory
compound, can modulate the response of the cells engaging in RA course.
Interestingly, many studies have described the potential role of
curcumin as an
epigenetic modifier. This potent herbal drug has been identified as an
inhibitor of DNA methyltransferases (DNMTs), regulator of histone
acetyltransferases (HATs), deacetylases (HDACs), and microRNAs, as well
as a
DNA binding agent. Curcumin has been found to significantly reduce H3ac
levels
in the IL-6 promoter as well as IL-6 mRNA expression in rheumatoid
arthritis
synovial fibroblasts (RASFs). The role of curcumin as an epigenetic
modifier
has been well documented in cancer, neurological disorders, and some
inflammatory diseases. Curcumin is a polyphenolic substance naturally
occurring
in turmeric, especially in Curcuma Longa, with broad anti-inflammatory
properties and proven positive effects in autoimmunological disease
therapies,
including Rheumatoid Arthritis. Curcumin is an antioxidant, which means
it can
efficiently reduce the level of reactive oxygen species (ROS), weaken
redox
signaling, and reduce inflammation [22]. In addition to having direct
antioxidant properties, curcumin also blocks the activity of
ROS-generating
enzymes like lipoxygenase (LOX), cyclooxygenase (COX), xanthine
dehydrogenase,
and nitric oxide synthase (iNOS). Despite reducing ROS levels, curcumin
also
possesses numerous other properties that enable its usage as a
potential
therapeutic drug targeted against Rheumatoid Arthritis. Interesting
insights
into this matter are provided by recent studies, which found that this
natural
compound can suppress proinflammatory pathways related to the immune
cells
crucial in RA development. Therefore, curcumin’s daily consumption
can
decrease inflammation and oxidative stress, contributing to the immune
system’s modulation and alleviating the rheumatoid arthritis course.
Curcumin
and cancer biology: Focusing regulatory effects in different signalling
pathways Phytotherapy Research | May
2021
Curcumin is a bright yellow substance isolated from the plant rhizomes
of
Curcuma longa L. To this molecule a high therapeutic benefit has been
underlined, being able to alter the development of cancer by different
mechanisms, such as regulating multiple microRNA expression, modifying a
series
of signalling pathways. Curcumin alleviates high-fat diet-induced
hepatic
steatosis and obesity in association with modulation of gut microbiota
in mice
Food Research International | May
2021
Curcumin alleviated hepatic steatosis and insulin resistance in obese
mice.
Curcumin increased abundance of Bacteroides, Parabacteroides, Alistipes
and
Alloprevotella. Curcumin increased the caecal and colonic short chain
fatty
acids (SCFA) contents. Curcumin reduced endotoxin-producing
Desulfovibrio
bacteria and circulating serum LPS. The dominant bacterial taxa altered
by
curcumin were related with improvement of obesity. The Effects of
Curcumin on
Diabetes Mellitus: A Systematic Review Frontiers in Endocrinology | May
2021
The genus Curcuma (Zingiberaceae) includes perennial rhizomatous plants
native
to subtropical to tropical regions. The main part of the plant is the
rhizomes,
and the most prevalent active components are the curcuminoids
(curcumin,
demethoxycurcumin, and bisdemethoxycurcumin). Curcuminoids are nontoxic
polyphenolic that exerts a wide range of biological activities, such as
the
production of significant immunosuppressants that inhibit the
production of
IL-2 and IL-12. This compound inhibits the expression of iNOS
(inducible nitric
oxide synthase), COX-2 (cyclooxygenase-2), lipoxygenase-5, and many
other
pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6, and IL-8.
Curcuminoids
can also regulate apoptosis and suppress neurotoxic factors in
macrophages and
alveolar monocytes stimulated by lipopolysaccharides. Besides, it
inhibits
phosphorylation and degradation of IκBα (nuclear factor of kappa
light
polypeptide gene enhancer in B-cells inhibitor, alpha) and activates
the γ
receptor mechanism activated by peroxisome proliferator, reducing
inflammation
pattern induced by NF-κBe biological effects may include the
inhibition of
reactive oxygen species (ROS) production, playing a fundamental role,
particularly for diseases related to oxidative stress and inflammation,
such as
DM. Figure 3 shows some systemic effects of curcumin. Curcumin is a
bioactive
component found Curcuma longa, which exhibits several physiological and
pharmacological properties such as antioxidant, anti-inflammatory,
anticancer,
neuroprotective, and anti-diabetic activities. For these reasons, our
objective
is to systematically review the effects of Curcuma longa or curcumin on
DM.
Databases such as PUBMED and EMBASE wereto its capacity to suppress
oxidative
stress and inflammatory process. Also, it significantly reduces fasting
blood
glucose, glycated hemoglobin, and body mass index. The singular
characteristic
of this plant is the presence of curcumin, which shows antioxidant and
anti-inflammatory properties. Besides that, curcumin has a potential
role in
preventing and treating several diseases due to various actions such as
anti-bacterial, anti-diabetic, anti-viral, and anticancer activities.
Curcuminoids have been shown to improve insulin resistance, decrease
glucose
and insulin levels, increase adiponectin release, and reduce the levels
of
leptin, resistin, interleukin (IL)-6 IL-1β, and tumor necrosis
factor-α in
patients with T2DM. These findings suggest that these compounds can
affect
glucose homeostasis and diabetic complications, and the vascular risk
of
patients with T2DM. Some studies have shown that supplementation of
curcuminoids improves the lipid profile and increases the total
antioxidant
capacity of patients with T2DM, thus supporting other available
evidence on the
role of curcuminoids in modifying cardiometabolic risks. Possible
Mechanisms
and Special Clinical Considerations of Curcumin Supplementation in
Patients
with COVID-19 Advances in Experimental Medicine and Biology | May
2021
Mechanisms and special clinical considerations of supplementation with
curcumin
as an anti-inflammatory and antioxidant compound in the setting of
COVID-19
clinical research. Anticancer Mechanism of Curcumin on Human
Glioblastoma
Nutrients | May
2021
Curcumin is the most studied compound described as a potential
anticancer agent
due to its multi-targeted signaling/molecular pathways properties.
Curcumin
possesses the ability to modulate the core pathways involved in GBM
cell
proliferation, apoptosis, cell cycle arrest, autophagy, paraptosis,
oxidative
stress, and tumor cell motility. This review discusses curcumin's
anticancer
mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh,
and
NF-κB pathways, which are commonly involved and dysregulated in
preclinical
and clinical GBM models. Micronutrients and bioactive substances: Their
potential roles in combating COVID-19 Nutrition | April
2021
A study has shown that curcumin interfered with the binding of
enveloped
viruses to cell surface. Derivatives of curcumin exhibited antiviral
activity
against the vesicular stomatitis virus. Curcumin also exhibited
antiviral
properties against dengue virus and hepatitis C virus. Having
immunomodulating,
antiinflammatory, antioxidant, and antiviral properties, such
micronutrients
and bioactive substances are consequently promising alterative
nutritional
approaches to combat COVID-19 infection. Curcumin suppresses colorectal
cancer
stem cells Journal of Natural Medicines | April
2021
Curcumin is a polyphenol extracting from Curcuma longa. It has been
demonstrated that curcumin possesses extensive therapeutic activities
against
multiple ailments, such as inflammation, metabolic syndrome, liver
disease,
arthritis, and neurodegenerative disease. In the recent years,
researchers
found that curcumin has played an important role in cancer prevention
and
treatment. For instance, curcumin induced apoptosis of
castration-resistant
prostate cancer cells, partially dependent on its iron-chelating
properties;
curcumin could overcome gefitinib-resistance in nonsmall-cell lung
cancer cells
via inducing autophagy-related cell death. Other studies indicated
curcumin
suppressed oncogenicity of human colon cancer cells, through covalent
modification of SIRT1 at the cysteine 67 residue and the proteasomal
degradation of oncogenic SIRT1. In this study, we observed that
curcumin
inhibited tumorsphere formation, decreased cell viability in a
dose-dependent
manner. Curcumin also promoted apoptosis of LGR5(+) colorectal CSCs. In
addition, curcumin can induce autophagy in many tumor cells. For
example,
curcumin inhibited proliferation, induced the autophagy and apoptosis
in
gastric cancer cells. Similarly, our data suggest that curcumin
increased tumor
cell death partly by inducing autophagy, because the effect of
curcumin-induced
cell proliferation inhibition was decreased by co-treatment with the
autophagy
inhibitor, HCQ. Therefore, these results reveal that curcumin-induced
autophagy
may contribute to the antitumor effects of curcumin on LGR5(+)
colorectal CSCs.
In summary, we found that curcumin suppresses the proliferation of
LGR5(+)
colorectal CSCs by inducing autophagy and transcriptionally repressing
the
oncogenic TFAP2A-mediated ECM pathway. Lastly, while our study entailed
mostly
in vitro experiments, further studies, especially in vivo, are needed
to
understand the mechanism of effect of curcumin in LGR5(+) colorectal
CSCs and
to evaluate this potential therapeutic approach to CRC. In addition,
the
correlation between TFAP2A-mediated ECM pathway and autophagy also
deserves
further study. Beneficial Effects of Curcumin Supplementation on Sports
Performance and Physical Exercise Designs For Health | April
2021
Turmeric has three main bioactive components: curcumin,
desmethoxycurcumin, and
bisdemethoxycurcumin. These curcuminoids have many biological effects,
including properties that are anti-inflammatory, antioxidant,
anti-tumor,
antimicrobial, and antiviral. This review investigated the evidence for
the
effects of curcumin supplementation for humans on sports performance
and
physical exercise. Curcumin possesses the ability to inhibit
transcription
factors (e.g., nuclear factor [NF]-κβ) that are responsible for
activating
pro-inflammatory enzyme and cytokine expression, such as cyclooxygenase
(COX)-2, 5-lipoxygenase (LOX-5), tumor necrosis factor (TNF)-α,
interleukin
(IL)-1, IL-6, and IL-8, suggesting their importance in helping to
reduce
post-exercise inflammation. The treatment groups with doses ranging
from 180 mg
to 5 g of curcumin per day showed significant reductions in
inflammation caused
by physical exercise compared to the placebo group, whose participants
displayed elevated IL receptor agonist activity of IL-6, IL-8, and
IL-10, and
TNF-α concentrations. Compared to the treatment group, a
gastrointestinal (GI)
barrier damage marker (fatty acid−binding protein) was elevated after
aerobic
exercise in the placebo group, suggesting curcumin may improve GI
function
during exercise-induced exertional heat stress. Overall, the results of
this
systematic review showed positive effects with no adverse symptoms or
injuries
reported. Curcumin supplementation improved exercise-induced muscle
recovery,
muscle performance, psychological and physiological parameters,
function, and
reduced inflammation, oxidative stress, pain, and muscle damage caused
by
aerobic and resistance training. Although larger clinical trials are
needed,
the evidence suggests that curcumin supplementation may be a safe and
effective
option for supporting sports and exercise performance in humans.
Curcumin
suppresses colorectal tumorigenesis Oncology Letters | April
2021
Curcumin, a natural product extracted from the rhizome of Curcuma
longa, is a
drug with strong pharmacological effects and limited side effects.
Increasing
evidence have confirmed that curcumin exerts antioxidant,
antibacterial,
anti-inflammatory, antiproliferation and anticancer effects.
Furthermore,
curcuminoids have advanced CRC who were resistant to chemotherapy for 4
months.
The results demonstrated that treatment with curcumin was well
tolerated and
there was no toxicity at any doses. Previous studies have reported
several
molecular mechanisms for the anticancer effects of curcumin . For
example,
curcumin inhibits Axin2 expression in the colorectal cancer line,
HCT116, and
modulates the Wnt/β-catenin signaling pathway. Yan et al demonstrated
that
Axin2 is upregulated and the Wnt/β-catenin signaling pathway is
activated in
human colon tumor samples. It has also been reported that curcumin can
target
colorectal stem cells via the Wnt pathway to inhibit their
proliferation and
drug resistance to chemotherapy, indicating the important role of the
Wnt/β-catenin signaling pathway in the tumorigenesis of CRC. Another
study
demonstrated that curcumin inhibits the proliferation and induces
apoptosis of
human non-small cell lung cancer cells via the PI3K/Akt signaling
pathway.
Furthermore, the results of a squamous cell carcinoma study reported
that
curcumin inhibits cancer cell proliferation via the epidermal growth
factor
receptor signaling pathway. In addition to the effects of curcumin on
CRC
progression through the NBR2/AMPK/mTOR pathway, curcumin regulates the
NF-κB
and Src protein kinase signaling pathways by inhibiting IκBα kinase
activation and IκBα phosphorylation. Collectively, these results
indicate
several molecular mechanisms of the anticancer effects of curcumin in
vitro.
However, the in vivo mechanism remains to be elucidated. Thus, the
present
study aimed to investigate the anticancer effects of curcumin and
determine its
underlying mechanisms in CRC, in vivo. Protective Effects of Curcumin
on Sperm
and Stereological Parameters in Testes of Formaldehyde-Exposed NMRI
Mice: An
Experimental Study International Journal of Medical Laboratory | April
2021
Curcumin (diferuloylmethane) is the main curcuminoid of turmeric, which
is a
known spice. It has been shown that curcuminoids are polyphenols and
are
responsible for the yellow-orange color of turmeric. Noorafshan and
colleagues
previously showed that curcumin protects the Leydig cells against
metronidazole
treatments. In another study, curcumin reduced testicular damage in
diabetic
rats by reducing oxidative stress.Moreover, Farombi et al. used
curcumin to
prevent oxidative changes and enhance sperm motility and reduce sperm
abnormalities. This study showed that curcumin could reduce
formaldehyde-induced damage to Telomerase: A Target for Therapeutic
Effects of
Curcumin in Cancer Advances in Experimental Medicine and Biology |
April
2021
Curcumin has been shown to be effective against several types of
malignancies
and has also been shown to have inhibitory effects on telomerase
activity.
Based on the findings obtained from the different studies here, we
conclude
that the telomerase inhibitory effects of curcumin are integral to its
anticancer activity, and thus curcumin may be useful therapeutically in
the
cancer field. Curcumin as Anti-infective Agents Current Medicinal
Chemistry |
April
2021
Curcumin, a redox-active natural product, has for centuries been used
in Asian
traditional medicine for the treatment of various diseases. It is known
for
possessing multiple biological and pharmacological activities. Curcumin
has
been investigated extensively over the years for its anti-inflammatory,
anticancer, antiparasitic, antiviral and antibacterial activities, and
no
toxicity is associated with the compound. Curcumin is still in clinical
trials
for the treatment of diseases The Antioxidant Effect of Curcumin and
Rutin on
Oxidative Stress Biomarkers Molecules | April
2021
Curcumin, from the root of the turmeric plant Curcuma longa, is an
extended
pseudosymmetric polyphenol (diferuloylmethane). Zhou et al. showed that
curcumin prevents bone loss in an experimental periodontitis model. In
association with studies that do demonstrate an effect on the
prevention of
bone loss, these investigations have shown that curcumin has a profound
effect
on inflammation by significantly reducing the development of an
inflammatory
infiltrates within the periodontal lesion while simultaneously
stimulating an
increase in the collagen content, as well as an increase in the number
of
fibroblastic cells within the periodontium and associated lesions when
curcumin
was administered daily to rats with experimentally induced
periodontitis.
Curcumin, the major component of turmeric, has been shown to have
anti-inflammatory, antimicrobial and antioxidant action. In vitro
studies,
animal studies and clinical studies have demonstrated that there is a
positive
association between curcumin and the evolution of periodontitis. It can
be
concluded that the oral administration of curcumin and rutin, single or
combined, could reduce oxidative stress both in gingival tissue and
blood and
enhance the antioxidant status in hyperglycemic periodontitis rats.
Modeling
oxidative stress, these two antioxidants may have an inhibitory effect
on
inflammation. Curcumin induces ferroptosis in nonâ€smallâ€cell lung
cancer
Thoracic Cancer | April
2021
Emerging studies showed curcumin can inhibit glioblastoma and breast
cancer
cells via regulating ferroptosis. Curcumin is a yellow polyphenol
compound
derived from the turmeric plant, which shows anticancer properties
through a
variety of mechanisms, including inhibition of tumor proliferation,
invasion
and metastases, regulation of apoptosis, and autophagy. Recent studies
showed
that curcumin can treat glioblastoma and breast cancer via regulating
ferroptosis. In conclusion, our results provide evidence that curcumin
could
induce ferroptotic cell death of NSCLC cells via activating autophagy.
Curcumin
Ameliorated Oxidative Stress and Inflammation-Related Muscle Disorders
Antioxidants | April
2021
Curcumin has also been reported to possess diverse pharmacological
effects
including antioxidant and anti-inflammatory activities. Recently, it
has been
suggested that curcumin alleviated chronic kidney disease-induced
muscle
atrophy by inhibiting glycogen synthase kinase (GSK)-3β. The present
study
demonstrated that curcumin in C2C12 myoblast cells showed in vitro
antioxidant
and anti-inflammatory activities. Specifically, curcumin enhanced DPPH
radical
scavenging activity in a dose-dependent manner, and it did not affect
the cell
viability of C2C12 cells with concentrations up to 30 μg/mL.
Furthermore,
curcumin significantly suppressed H2O2-induced cell toxicity, ROS
generation,
and lipid peroxidation and restored GSH depletion, which involved an
increase
of antioxidant genes through Nrf2 activation, providing evidence that
curcumin
can protect cells by reducing oxidative stress. Besides, curcumin
significantly
inhibited LPS-mediated IL-6 productions. Therefore, curcumin could be a
useful
candidate against oxidative stress and inflammation-related muscle
disorders.
Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation ACS
Omega |
April
2021
Curcumin is a polyphenolic substance extracted from turmeric, a plant
of the
curcuma family. Toxicity studies have shown that it is quite safe even
at high
doses the United States. Curcumin, as an effective anti-inflammatory
small
molecule, was shown to inhibit the COX-2 expression in human colon
cancer
cells. Recently, Wang et al. have proven that curcumin can inhibit
ApoE4-induced injury by upregulating the expression of peroxisome
proliferator-activated receptor-γ to inhibit the activation of NF-κB
signaling in SH-SY5Y cells. Apart from the anti-inflammatory role,
curcumin
also acts as a known antioxidant that scavenges reactive oxygen
species. Zheng
et al. found that curcumin can protect SH-SY5Y cells against
appoptosin-induced
intrinsic caspase-dependent apoptosis by increasing heme oxygenase-1
expression
and reducing ROS production. Chhunchha et al. also proposed that
curcumin could
reinforce the naturally occurring Prdx6 expression, attenuate ROS-based
ER
stress and NF-κB-mediated aberrant signaling, then improve the
survival of
mouse hippocampal cells (HT22), and may provide an osteoarthritis
development
in vivo. Together, the previous studies focused either on the
anti-inflammatory
effect of curcumin in vitro under various stimuli or on its protection
against
ER stress in other inflammatory diseases. Curcumin protects against
inflammation and lung injury in rats with acute pulmonary embolism
Molecular
and Cellular Biochemistry | April
2021
Curcumin decreased miR-21 expression by downregulating Sp1 to
upregulate PTEN
and to impair the NF-κB signaling pathway, thus suppressing lung
injury and
inflammation in APE rats. Antiviral and immunomodulatory activity of
curcumin:
A case for prophylactic therapy for COVID-19 Heliyon Cell Press | March
2021
Curcumin, a bioactive compound in turmeric, exerts diverse
pharmacological
activities and is widely used in foods and traditional medicines. This
review
presents several lines of evidence, which suggest curcumin as a
promising
prophylactic, therapeutic candidate for COVID-19. First, curcumin
exerts
antiviral activity against many types of enveloped viruses, including
SARS-CoV-2, by multiple mechanisms: direct interaction with viral
membrane
proteins; disruption of the viral envelope; inhibition of viral
proteases;
induce host antiviral responses. Second, curcumin protects from lethal
pneumonia and ARDS via targeting NF-κB, inflammasome, IL-6 trans
signal, and
HMGB1 pathways. Third, curcumin is safe and well-tolerated in both
healthy and
diseased human subjects. In conclusion, accumulated evidence indicates
that
curcumin may be a potential prophylactic therapeutic for COVID-19 in
the clinic
and public health settings. Curcumin suppresses the stemness of
nonâ€small
cell lung cancer cells Environmental Toxicology | March
2021
Curcumin has been shown to suppress the progression of lung cancer,
however,
the underlying mechanisms are largely unknown. Our results suggest that
curcumin can attenuate the stemness of lung cancer cells through
promoting TAZ
protein degradation and thus activating Hippo pathway. The Effect of
Curcumin
Supplementation on Overweight or Obese Adults Nutrients |
2021
Curcumin has been shown to play a beneficial role in obesity
management.
Therefore, exploring the effects of certain herbs or dietary spices on
obesity
may be promising. Among these spices, curcumin, which is the primary
component
of the spice turmeric, has gained great interest for its multiple
health
benefits. Several randomized controlled trials have investigated the
potential
favorable effects of curcumin supplementation on anthropometric
measures. The
aim of this review is to evaluate the effect of curcumin
supplementation on the
anthropometric indices among overweight or obese adults. Curcumin
supplementation may exert beneficial effects against obesity among
overweight
or obese adults. Anticancer Mechanism of Curcumin on Human Glioblastoma
Nutrients |
2021
Curcumin is the most studied compound described as a potential
anticancer agent
due to its multi-targeted signaling/molecular pathways properties.
Curcumin
possesses the ability to modulate the core pathways involved in GBM
cell
proliferation, apoptosis, cell cycle arrest, autophagy, paraptosis,
oxidative
stress, and its anticarcinogenic, antitumor, antioxidant, and
anti-inflammatory
actions. Curcumin is the most abundant compound and has been widely
studied as
a potential therapeutic agent in chronic diseases, such as
neurodegenerative,
cardiovascular, pulmonary, metabolic, and autoimmune diseases. For
instance,
curcumin was able to restore oxidative stress and DNA methyltransferase
(DNMT)
functions against diabetic retinopathy. Curcumin also acts as a wound
healing
promoting agent by facilitating collagen synthesis and fibroblast
migration.
Several pre-clinical and clinical studies also reported its anticancer
effects
in colorectal cancer, pancreatic cancer, lung cancer, and GBM. Curcumin
can
modulate multiple cellular signaling pathways and molecular targets
involved in
GBM tumor growth, migration, invasion, cell death, and proliferatio.
Retinoblastoma (Rb), p53, MAP kinase (MAPK), P13K/Akt, JAK/STAT, sonic
hedgehog
(Shh), and NF-κB pathways are the most common targeted dysregulated
pathways
found in GBM and modulated by curcumin. Moreover, curcumin is highly
lipophilic
and able to Curcumin + Celecoxib: a synergistic and rationale
combination
chemotherapy for breast cancer European Review for Medical and
Pharmacological
Sciences | March
2021
This study is designed to explore the synergistic inhibitory effect of
the
combination of curcumin and celecoxib on the growth of human breast
cancer
cells. Our findings show the prominent anti-proliferative effects of
celecoxib
and/or curcumin on MDA-MB-231 cells, providing a rationale for further
detailed
preclinical and potential clinical studies of this combination for
breast
cancer therapy. Further, these computed parameters suggested that
curcumin
possesses a high tendency to act as an adjuvant drug with celecoxib in
the
treatment of breast cancer. Immune-Stimulatory Effects of Curcumin on
the Tumor
Microenvironment in Head and Neck Squamous Cell Carcinoma Cancers |
March
2021
Curcumin is known to have immune-modulatory and antitumor effects by
interacting with more than 30 different proteins. An important feature
of
curcumin is the inhibition of nuclear factor kappa of activated B-cells
(NF-κB). Curcumin was more effective in inhibiting PIC-dependent
NF-κB
activation and Treg attraction compared to known NF-κB inhibitors BAY
11-7082
or caffeic acid phenethyl ester. The presented results show, for the
first
time, the immune-modulating effects of curcumin in HNSCC, with potent
inhibition of the Treg-attracting effects of PIC. Hence, curcumin
presents a
promising drug in cancer therapy as a supplement to already established
treatments. Curcumin with Promising Protection against Herpesvirus
Infections
and Their Associated Inflammation Microorganisms | March
2021
Curcumin is the key component of the yellow pigment and the main
bioactive
molecule of turmeric. Chemically, this compound belongs to the class of
natural
phenolic compounds and has been broadly identified in diverse Curcuma
spp. In
1910, curcumin was characterized as a symmetrical molecule of two
4-hydroxy-3-methoxyphenyl rings fastened by α,β-unsaturated carbonyl
groups,
while its synthesis was defined in 1913. Curcumin has been employed
widely in
the traditional medicine systems of various countries and regions in
the world.
Since the complete information about chemical structure and synthesis
is
acquired, curcumin has been extensively studied in various biological
assays
and has proven to induce numerous pharmacological and beneficial
impacts on
human health, including but not limited to the potential treatment of
various
viral infections such as human immunodeficiency virus, hepatitis B
virus,
hepatitis C virus, influenza A virus, human papillomavirus, respiratory
syncytial virus, arboviruses, and noroviruses. Unlike the notable
antimicrobial
actions, this biomolecule induces several biological effects including
but not
limited to antioxidant, anti-inflammatory, and anticancer properties.
We
reviewed the curative properties of curcumin, a principal bioactive
phenolic
compound of the spice turmeric, in regard to various human and animal
herpesvirus infections and inflammation connected with these diseases.
According to the reviewed studies, this paper presents curcumin as a
promising
natural drug for the prevention and treatment of herpesvirus infections
and
their associated inflammatory diseases. In recent years, curcumin as a
nutraceutical agent has attracted major attention in many research
fields due
to its great therapeutic potential against various biological targets.
We have
comprehensively reviewed the curative values of curcumin against
numerous
animal and human herpesviruses along with the mechanisms by which this
compound
induces antiherpetic properties, which were examined in vitro and in
vivo
investigations. Based on several structure-activity relationship
studies,
hydroxyl groups, carbonyl groups, and phenyl rings of curcumin were
observed to
be accountable for the induced anti-herpesvirus properties. In
conclusion, this
review proposes curcumin as a potent and safe drug for the therapy of
herpesvirus infections as well as inflammation associated with these
infections. Roles of Curcumin in Sensitising the Cisplatin Effect on a
Cancer
Stem Cell-Like Population Derived from Non-Small Cell Lung Cancer Cell
Lines
Molecules | March
2021
Natural compounds such as curcumin that contain high amounts of
polyphenols can
have a chemosensitivity effect that sensitises CSCs to cytotoxic agents
such as
cisplatin. Curcumin significantly suppressed colonies formation by 50%
and
shrank the spheroids in cancer stem ce subpopulations, indicating
inhibition of
their self-renewal capability. This effect also was manifested by the
down-regulation of SOX2, NANOG, and KLF4. Curcumin also regulated the
niche of
cancer stem cells by inhibiting chemoresistance proteins, aldehyde
dehydrogenase, metastasis, angiogenesis, and proliferation of
cancer-related
proteins. These results show the potential of using curcumin as a
therapeutic
approach for targeting cancer stem cells subpopulations in non-small
cell lung
cancer. Curcumin (diferuloylmethane) is a naturally occurring
polyphenol
extract that is found in turmeric. Curcumin has long been used as a
food,
cosmetic, and traditional herbal molecules and pathways without any
associated
toxicity or resistance. One of the most compelling reasons for
exploring
curcumin is its sensitiser properties, which influence a diverse range
of
molecular targets within cells. Focus on Multi-targeted Role of
Curcumin: a
Boon in Therapeutic Paradigm Environmental Science and Pollution
Research |
March
2021
After thoroughly studying several articles on combination therapy of
curcumin
through authenticated book chapters, websites, research, and review
articles
available at PubMed, ScienceDirect, etc., it has been observed that
multi-targeted curcumin possess enormous anticancer potential and, with
whatever drug it is given in combination, has always resulted in
enhanced
effect with reduced dose as well as side effects. It is also capable
enough in
overcoming the problem of chemoresistance. Combining all the factors
together,
we can conclude that combination therapy of drugs with curcumin should
be
explored extensively Efficacy of curcumin/turmeric on liver enzymes in
patients
with non-alcoholic fatty liver disease Integrative Medicine Research |
March
2021
Meta-analysis of 4 randomized controlled trials including 228 subjects
showed a
trend toward significant reduction of ALT blood concentrations suggests
that
curcumin/turmeric might have a favorable effect on NAFLD in higher
dosage.
Curcumin suppresses tumor growth of gemcitabine-resistant non-small
cell lung
cancer Clinical and Translational Oncology | March
2021
Curcumin has been reported to block cancer development by modulating
multiple
signaling pathways. The results showed that curcumin suppressed
gemcitabine-resistant non-small cell lung cancer cell proliferation and
induced
apoptosis. Curcumin upregulated the expression of lncRNA-MEG3 and PTEN,
and
MEG3 overexpression could increase the level of PTEN expression, while
MEG3
knockdown decreased the level of PTEN expression in
gemcitabine-resistant
non-small cell lung cancer cells. These findings show the antitumor
activity of
curcumin for potential clinical application in gemcitabine-resistant
non-small
cell lung cancer treatment. Curcumin antiâ€tumor effects on
endometrial cancer
with focus on its molecular targets Cancer Cell International | March
2021
Curcumin is a phenolic antioxidant extracted from turmeric, which is
frequently
used as a spice and has a yellow color. The rhizome of the herb Curcuma
longa
is the origin of turmeric that contains turmerin protein as well as
analogs of
curcumin, demethoxycucumin, and bisdemethoxycurcumin.
1,7-bis(4-hydroxy-3-
methoxyphenyl)-1,6-heptadiene-3,5-dione is the chemical name of
curcumin and
C21H20O6 is its empirical formula. Since curcumin and its two analogs
have the
same molecular and biological characteristics, it is suggested that
bisdemethoxycurcumin converts to demethoxycucumin, which in turn,
transforms
into curcumin. While curcumin plays a variety of beneficial roles,
studies on
animals and humans have concluded that it is a safe agent even at high
doses.
Curcumin acts as an anti-oxidative, anti-microbial, anti-malarial,
anti-HIV,
and anti-angiogenic agent. Furthermore, it can be used in the treatment
of
inflammation, skin wounds, and neurodegenerative diseases. Curcumin has
complex
chemistry and it is capable of targeting some signaling pathways.
Moreover, it
can interact with several intracellular and extracellular molecules.
These
features lead to anti-tumor effects of curcumin on various cancer cells
and is
useful at different stages, including prevention, treatment, and
controlling
the symptoms of cancers. There are studies concerned with the
anti-tumor
effects of curcumin in the treatment of EC. Curcumin plays these roles
by
involving various targets, such as signaling pathways, proteins, genes,
and
RNAs. Induction of apoptosis, reducing inflammation, and inhibiting
cell
migration are the results of curcumin treatment. Furthermore, there are
some
miRNAs whose effects on EC have been identified and curcumin has been
observed
to impact on these miRNAs but in other cancers. Altogether, curcumin
should be
considered as a therapeutic target in EC and its anti-tumor effects on
this
cancer deserve further exploration. The protective effects of curcumin
in
cerebral ischemia and reperfusion injury through PKC-θ signaling Cell
Cycle |
March
2021
Curcumin, a known antioxidant, has been found to have neuroprotective
effects.
To determine the protective mechanism of curcumin in ischemic stroke,
oxygen
and glucose deprivation/reoxygenation (OGD/R) was used to treat PC12
cells to
mimic the cerebral I/R cell model. Our results demonstrated that
curcumin could
reverse the MCAO/R-induced increase in Ca2+ concentration and
blood–brain
barrier (BBB) disruption. Our study demonstrates the mechanisms by
which
curcumin exhibited a protective function against cerebral I/R through
PKC-θ
signaling by reducing BBB dysfunction. Curcumin promotes cell cycle
arrest and
apoptosis of acute myeloid leukemia cells by inactivating AKT Oncology
Reports
| March
2021
Curcumin, a phytochemical from rhizomes of the plant Curcuma longa, has
been
reported to exert potential anticancer properties in various cancer
types,
including acute myeloid leukemia (AML). The present study demonstrated
the
anti-AML effect of curcumin both in vitro and in vivo. Curcumin repairs
intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer
National Library of Medicine | March
2021
Curcumin maintained the integrity of mucosal surface and villi
structure of
jejunum to a large extent, and reduced pathological changes in a
dose-dependent
manner. Meanwhile, curcumin could increase the positive expression of
occludin,
claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier
function,
downregulate the protein expression of IL-6, p-STAT3, vimentin and
N-cadherin
in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein
expression of
E-cadherin(P<0.05). Therefore, curcumin could repair the intestinal
mucosal
injury induced by 5-FU chemotherapy for colon cancer, and the mechanism
may be
related to the inhibition of IL-6/STAT3 signal and the inhibition of
epithelial-mesenchymal transition(EMT) process. Effect of Curcumin,
Exelon and
their Combination on Brain in Alzheimer’s Disease-Induced Rats
Journal of
Advances in Medicine and Medical Research | March
2021
Curcumin is a natural product derived from Curcuma longa (more commonly
known
as turmeric). Curcumin has anti-inflammation and antioxidant
activities, so it
can decrease inflammation, amyloid accumulation and oxidative stress
which has
ability to scavenge free radicals. Also, it has protective potent from
lipid
peroxidation, and scavenges nitric oxide (NO)-based radicals. Curcumin
has
ability to inhibit formation of Aβ plaques and lower soluble Aβ
levels due to
its metal chelation properties as it binds to redox-active metal ions
such as
iron and copper. These complexes may cause a net protective effect
through
decreased Aβ aggregation. Curcumin is safe product which large
quantities can
consumed without toxicity. How curcumin affects hyperglycemia-induced
optic
nerve damage: A short review Journal of Chemical Neuroanatomy | March
2021
Curcumin is effective in preventing the progression of diabetic
complications
and improving complications. Curcumin has healing effects in optic
nerve damage
with its anti-oxidant properties. Effects of curcumin administration on
Nesfatin-1 levels in blood, brain and fat tissues of diabetic rats
European
Review for Medical and Pharmacological Sciences | March
2021
Curcumin administration caused significant improvement in fasting blood
glucose
levels. For the first time, we found marked improvements in nesfatin-1
levels
in blood, brain, and fat tissues of type 2 DM rats. Thus, considering
the
crucial role of nesfatin-1 in regulation of glucose metabolism, it is
logical
to expect an interactive relationship between curcumin and nesfatin-1.
Curcumin
Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote
the
Anabolism of Articular Chondrocytes and Cartilage Repair Cell
Transplantation |
March
2021
Curcumin displayed multiple pharmacological activities including
anti-inflammatory, antioxidant, and anticancer, and has been employed
in
different studies involving several pathologies such as cardiovascular
disease,
depression, Alzheimer’s disease, epilepsy, Parkinson’s disease,
cancer,
osteoporosis, rheumatic arthritis, and osteoarthritis. It could inhibit
the
activation of nuclear factor kappa-light-chain-enhancer of activated B
cells
(NF-κβ) and synthesis of reactive oxygen species by reducing the
production
of IL-1, IL-6, IL-8, and tumor necrosis factor α via various pathways,
and is
emerged as an effective therapeutic agent. For osteoarthritis
treatment,
curcumin supplementation exhibited effects mainly based on its
anti-inflammation, antioxidant, and antiapoptosis potentials15. In
clinical
trials, curcumin served as a natural product medicine displayed nearly
no side
effects, thus making it a potential alternative to NSAIDs and some
other
medications with known severe adverse effects. In the current study,
curcumin
enhanced the BMSC function for the proliferation and migration of
articular
chondrocytes, and anabolic gene expression of ECM in articular
chondrocytes in
vitro, and the regeneration of articular cartilage in vivo. These
results
indicated potential clinical application of curcumin cooperation with
BMSCs in
cartilage repair for osteoarthritis treatment. Curcumin for amyloidosis
and
lipid metabolism - a novel insight eLife Shinshu University | March
2021
Curcumin is a polyphenol compound produced by plants of the Curcuma
longa
species and has been reported to have many physiological activities,
which
include anti-oxidation, anti-inflammatory, anti-cancer, and
anti-amyloid
properties. In previous studies, curcumin has been shown to suppress
the
aggregation and cytotoxicity of many amyloid proteins in vitro, such as
amyloid
ß (Aß), α-synuclein, transthyretin, and prion protein, and has also
been
reported to inhibit the deposition of Aß fibrils in a mouse model of
Alzheimer's disease. These findings demonstrate the novel agonistic
effect of
curcumin on PPARα, which is an important transcription factor for
lipid
metabolism, and may have far-reaching significance for the treatment of
amyloidosis and other metabolic disorders. In addition, it has been
regarded
that curcumin, as an agonist of PPARγ, exerts anti-inflammatory,
anti-cancer
and antioxidant activities in the past. However, this study
demonstrates that
curcumin is a PPARα/γ dual activator and may affect expression levels
of
proteins involved in amyloid deposition and other metabolism functions
in a
complex manner. By focusing on the PPARα pathway, the group hope to
provide an
opportunity to reconsider the mechanism of the physiological effects of
curcumin. A protective effect of curcumin on cardiovascular oxidative
stress
indicators in systemic inflammation induced by lipopolysaccharide in
rats
Biochemistry and Biophysics Reports | March
2021
Administration of curcumin attenuated oxidative stress and inflammation
in the
serum, aorta and heart tissues induced by lipopolysaccharide LPS.
Anti-inflammatory Effect of Curcumin on Human Vitreous in Patients With
Diabetic Retinopathy Frontiers in Neurology | March
2021
Curcumin, a yellowish non-flavonoid polyphenol that constitutes the
main active
compound of Curcuma longa, is widely known for its antioxidant and
anti-inflammatory properties. Many studies have also described its
marked
protective effect on retinal cells against oxidative stress and
inflammation.
Curcumin is a well-known bioactive molecule, largely employed in
supplement
formulation due to its anti-inflammatory properties. Our study
highlighted the
ability of curcumin to reduce cytokine levels in the vitreous of
diabetic
patients. We also observed an additional anti-inflammatory effect when
curcumin
was combined with homotaurine and vitamin D3, suggesting that these
molecules
can regulate the inflammatory network between the vitreous and retina
at
different levels. This effect is confirmed by the gene expression
experiment
which demonstrated that the combination of curcumin, vitamin D3, and
homotaurine down-regulate the cyclinD1 gene and the pro-inflammatory
cytokine
genes TNFα and IL6 expression. Curcumin induces mitochondrial
biogenesis by
increasing cAMP levels via PDE4A inhibition in skeletal muscle British
Journal
of Nutrition | March
2021
Previous research has suggested that curcumin potentially induces
mitochondrial
biogenesis in skeletal muscle via increasing cAMP levels. The present
results
suggest that curcumin increases cAMP levels via inhibition of PDE4A
phosphorylation, which induces mitochondrial biogenesis through a
cAMP/PKA/AMPK
signalling pathway. Our data also suggest the possibility that curcumin
utilizes a regulatory mechanism for mitochondrial biogenesis that is
distinct
from the exercise-induced mechanism in skeletal muscle. Catechin and
curcumin
interact with S protein of coronavirus SARS-CoV2 and ACE2 of human cell
membrane Scientific Reports | February
2021
Several recent studies have suggested that natural polyphenolic
compounds like
catechins (GTCs; Green Tea Catechins) and curcumin (diferuloylmethane;
from
turmeric) have antiviral activities against a broad spectrum of viruses
such as
Human Immunodeficiency Virus (HIV), Herpes Simplex Virus, Influenza
Virus,
Hepatitis B and C Viruses (HBV and HCV respectively)14, Adenovirus15
and
Chikungunya virus (CHIKV). Diverse mechanisms have been suggested to
explain
the antiviral activities of both the polyphenolic compounds. Curcumin
has been
demonstrated as a potent inhibitor of monophosphate dehydrogenase, a
rate
limiting enzyme in the de novo synthesis of guanine nucleotide22.
Further, it
has also been observed that GTCs and curcumin inhibit the expression of
ACE2
ASU study looks at how Curcumin supplements might help post-COVID
AZFamily.com
| February
2021
Researchers at Arizona State University are conducting a study into if
whether
or not two supplements can help reduce inflammation after having
COVID-19. An
ASU grad student is part of a research team, hoping to learn whether or
not two
supplements reduce inflammation after COVID-19. "It can either be
Curcumin,
which comes from the spice turmeric," said ASU Grad Student Samantha
Fessler.
"...the other one is Palmitoylethanolamide, and that comes from things
like
eggs and peanut oil...using these supplements with the flu, they've
been proven
to improve inflammation associated with the flu viral infection and
also
post-recovery from other types of chronic issues." The potential role
of
curcumin in the prevention of COVID-19 Archives of Microbiology |
February
2021
Due to the new coronavirus’ unexplored nature, we shed light on
curcumin for
its potential role against the disease. The current study showed the
use of
curcumin against the coronavirus and its possible role in developing
medicine
against it. Curcuma longa produces turmeric (diferuloylmethane), named
Indian
saffron in Europe, with its medicinal uses, including antiviral and
anti-inflammatory actions. It has shown that curcumin has its
inhibitory
effects on the virus, including HIV, smallpox, measles, and chickenpox
are
being among its target. In the current study, we showed the possible
use of
curcumin in the prevention of COVID-19 by targeting the virus replicase
protein
Nsp9. Turmeric is the principle source of curcumin, and in India it is
used as
an essential daily ingredient in the food preparation while it has its
own
antiviral, antifungal, antiallergic properties. Hence, it is preferred
over
other medicinal compounds in the present study. As curcumin also showed
the
antiviral properties, the interaction of curcumin and Nsp9 may be
useful in
understanding the novel SARS Cov-2. This supports the use of curcumin
to reduce
the pathological consequences that emerged due to coronavirus
infection. So, by
targeting the ssRNA of coronavirus at its initial replication stage,
through
curcumin, when it enters the human is a matter of immediate in-vivo
research to
possibly overcome the COVID-19 and explore the inhibitory pathways of
curcumin
to prevent the new coronavirus replication machinery in the human
system.
Curcumin: reclaiming the lost ground against cancer resistancee leydig
testosterone Cancer Drug Resistance | February
2021
Curcumin, a polyphenol, has a wide range of biological properties such
as
anticancer, antibacterial, antitubercular, cardioprotective and
neuroprotective. Moreover, the anti-proliferative activities of
Curcumin have
been widely studied against several types of cancers due to its ability
to
target multiple pathways in cancer. A large number of reported studies
and
increasing interest of researchers have reinforced the claim of
curcumin being
one of the most sought after natural product in the fight against
cancer.
Curcumin, is a polyphenolic compound of up to 5% present in turmeric.
Curcumin
as a phytochemical has been widely explored for its therapeutic
potential
through in vitro and in vivo investigations. It has been shown to
possess
biological activity against a large spectrum of physiological
conditions, which
include antioxidant, chemo-protective, anti-diabetic and
anti-proliferative
activity against cancer cells. Curcumin has shown commendable potential
during
in vitro and in vivo studies against vrious cancers. It has also been
established through clinical trials that curcumin does not show any
adverse
effect upto a daily dose of 8 g to 12 g. The combinatorial treatment of
curcumin has been shown to sensitize the drug-resistant cancer towards
existing
anticancer drugs and this aspect of combinatorial treatment can be
exploited to
fully utilize the curative potential of curcumin. In the near future,
curcumin
may play an important role in chemotherapeutic regimes against
different types
of cancers. A Review of the Possible Effects of Curcumin in the
Treatment of
COVID-19 Journal of Military Medicine | February
2021
Curcumin is a natural polyphenolic compound, which could be a potential
treatment option for patients with Covid-19. In this study, we review
some of
the possible effects of curcumin, such as inhibiting virus entry into
the cell,
inhibiting virus replication and viral protease, as well as modulating
some
intracellular messenger pathways. To comprehensive literature review,
information from an internet search of English language databases
PubMed,
Scopus, Web of Science and ScienceDirect as well as Persian language
databases
such as SID using related keywords based on MESH such as COVID-19,
SARS-COV-2 ,
Curcumin and curcuminoid between January
2020
and January
2021
were collected. This review provides some possible effects of curcumin
and its
mechanisms for the treatment of COVID-19. Ten Days of Curcumin
Supplementation
Attenuates Subjective Soreness and Maintains Muscular Power Following
Plyometric Exercise Journal of Dietary Supplements | February
2021
Curcumin has become a popular product used to decrease inflammation and
enhance
recovery from exercise. Purpose: To determine the effects of curcumin
supplementation on delayed onset muscle soreness and muscle power
following
plyometric exercise. Conclusion: These data suggest curcumin reduces
soreness
and maintains muscular power following plyometric exercise. Curcumin:
Natural
Antimicrobial and Anti Inflammatory Agent Journal of Pharmaceutical
Research
International | February
2021
Various studies, conducted as in vitro assays, have revealed different
therapeutic applications of curcumin due to its different molecular
mechanisms.
Findings of the present in vitro study confirmed consideration of
curcumin as a
natural antimicrobial and anti-inflammatory agent. Test curcumin
solutions
demonstrated strong antibacterial, antifungal and anti-inflammatory
activity.
With an increase of curcumin concentration antimicrobial and
anti-inflammatory
activity increased, which implied that observed activity is dependent
upon the
concentration of curcumin. In conclusion, the present study emphasises
the
potential application of curcumin as a natural antimicrobial and
anti-inflammatory agent. Oral supplementation of curcumin for three
months
reduces p-CS plasma levels in hemodialysis patients, suggesting a gut
microbiota modulation International Urology and Nephrology | February
2021
Nutritional strategies, such as bioactive compounds present in
curcumin, have
been proposed as an option to modulate the gut microbiota and decrease
the
production of uremic toxins such as indoxyl sulfate (IS), p-cresyl
sulfate
(pCS) and indole-3 acetic acid (IAA). Effects of Curcumin on Glycemic
Control
and Lipid Profile in Polycystic Ovary Syndrome Nutrients | February
2021
Curcumin has been studied to adjunctly treat broad spectrum of disease
from
type 2 diabetes mellitus to telogen effluvium. Curcumin elicits
antidiabetic
effects via several mechanisms, including the increase in glycolysis
and
glycogen synthesis and the decrease in gluconeogenesis in the liver, as
well as
the increase in glucose uptake, glycolysis, and glycogen synthesis in
the
skeletal muscle. Curcumin has also been known to reduce plasma
cholesterol and
triglyceride by increasing the activity of lipoprotein lipase and
through
mechanisms which alter lipid and cholesterol gene expression. In
addition, the
anti-inflammatory effects of curcumin have been demonstrated to reduce
the
oxidative stress in patients with PCOS. Previous literature reveals
that
curcumin significantly improves fasting blood glucose and triglyceride
in
patients with metabolic syndrome. In vivo study further demonstrates
similar
effects in the PCOS model. Curcumin significantly improves fasting
glucose,
fasting insulin, Homeostasis Model Assessment of Insulin Resistance,
and
quantitative insulin sensitivity check index. It also significantly
improves
high-density lipoprotein and total cholesterol. Curcumin may improve
glycemic
control and lipid metabolism in patients with PCOS and metabolic
abnormality
without significant adverse effects. Curcumin may improve glycemic
control and
lipid metabolism in patients with PCOS and metabolic abnormality
without
significant adverse effects. Further studies are advocated to
investigate the
potential effects of curcumin on hyperandrogenism. Curcumin promotes
cell cycle
arrest and apoptosis of acute myeloid leukemia Oncology Reports |
February
2021
Curcumin is the main polyphenol component extracted from rhizomes of
the plant
Curcuma longa, and its therapeutic benefit has been demonstrated in
various
cancer types, including AML. However, the underlying mechanism is
complex and
remains poorly understood, as curcumin has multiple targets and is
involved in
various signaling pathways. Afuresertib has been reported to exert
antitumor
effects in ovarian cancer, malignant pleural mesothelioma and chronic
lymphocytic leukemia. However, to the best of our knowledge, its role
in AML
has not been previously reported. The present study was the first
report that
afuresertib could potentially be used for the treatment of AML.In
conclusion,
the present study demonstrated that curcumin decreased the survival and
proliferation of AML cells in vitro, as well as AML cell proliferation
in
hematopoietic tissue and dissemination . The Multifaced Actions of
Curcumin in
Pregnancy Outcome Antioxidants | February
2021
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione),
also
known as diferuloylmethane, is a polyphenolic yellow substance coming
from the
rhizomes, the most commonly used plant part, of Curcuma longa Linn
(Zingiberaceae family). Curcumin structure is similar to other
bioactive
non-volatile curcuminoids such as dimethoxy-curcumin and
bisdemethoxy-curcumin,
differing only for the number of methoxy groups on their aromatic
rings. This
plant has been used since ancient times for both food and
pharmaceutical
purposes, showing a variety of beneficial effects in the organism
reducing
glycemia, hyperlipidemia, insulin resistance and steatosis in
non-alcoholic
fatty liver disease (NAFLD). Moreover, due to the cytotoxic effects of
curcumin
on tumor cells, this compound showed good effects also as an anticancer
agent
inhibiting tumor proliferation and inducing apoptosis in many cancer
types
including breast, colon, lung and gastric cancer. Curcumin has been
extensively
studied in various fields, showing a wide range of action, including
Antioxidant, anti-inflammatory, anti-toxicant, anti-apoptotic,
anti-diabetic
and immunomodulatory actions, demonstrated by in vitro studies and
animal
models, suggest the use of this compound as a therapeutic agent in
counteracting several pregnancy complications. Inflammation, oxidative
stress,
Reactive Oxygen Species (ROS) generation and apoptosis are common
conditions
usually found in almost all of the pathological placental conditions
mentioned
above; for this reason, curcumin could play a key role in improving
pregnancy
outcome in these complications. To date, there are many clinical trials
studying the efficacy of curcumin in many types of cancer that
generally
consider curcumin as well tolerated and efficient adjuvant therapy
ameliorating
the response to chemotherapy and radiotherapy reducing the side effects
of
these therapies. Clinical effects of curcumin have also been shown in
other
pathologies. In fact, curcumin improved the severity of patients
affected by
non-alcoholic fatty liver diseases (NAFLD) disease decreasing the serum
concentrations of inflammatory cytokines and chemokines such as TNF-α
and
MCP-1. Moreover, curcumin intake in women with polycystic ovarian
syndrome
(PCOS) significantly increased gene expression of PGC1α and activity
of the
Gpx enzyme reducing oxidative stress. Another clinical trial showed
that
curcumin was able to improve the symptoms in patients affected by knee
osteoarthritis. Beneficial curcumin effects were also found in clinical
trials
focused on its role in body weight regulation, finding a role for
curcumin in
reducing BMI and increasing weight loss in addition to decreased serum
levels
of IL1β, IL-4 and VEGF. Moreover, curcumin administration in two
clinical
trials showed that curcumin could decrease glucose levels in patients
with type
2 diabetes mellitus. Due to its multifaced role in regulating different
signaling and the encouraging data obtained in animal models and in
vitro
studies, curcumin intake during pregnancy could be beneficial in almost
all the
pregnancy complications mentioned in this review. Antioxidant Activity
of
Curcumin Protects against the Radiation-Induced Micronuclei Formation
International Journal of Radiation Biology | February
2021
Curcumin when treated at a dose of 0.5 μg/mL attenuated micronuclei
formation after γ-irradiation by inhibiting the formation of
radiation-induced
free radicals. Curcumin significantly alleviated cognitive deficits
induced by
cerebral ischemia. Brain Research | February
2021
Curcumin ameliorates acute cerebral ischemia-induced cognitive
dysfunction in
mice. Curcumin promotes hippocampal NSCs proliferation and
differentiation into
neurons. Curcumin promotes hippocampal neurogenesis through
Wnt/β-catenin
signaling pathway. Recent Advances in the Synthesis and Development of
Curcumin, its Combinations, Formulations and Curcumin-like Compounds as
Antiinfective Agents Current Medicinal Chemistry | February
2021
Curcumin, a redox-active natural product, has for centuries been used
in Asian
traditional medicine for the treatment of various diseases. It is known
for
possessing multiple biological and pharmacological activities. Curcumin
has
been investigated extensively over the years for its anti-inflammatory,
anticancer, antiparasitic, antiviral and antibacterial activities, and
no
toxicity is associated with the compound. Despite its potency and
safety
profile, curcumin is still in clinical trials for the treatment of
diseases,
such as tuberculosis, acquired immunodeficiency syndrome (AIDS),
Crohn's
disease, colorectal cancer and multiple myeloma, among many others, as
it is
yet to be qualified as a therapeutic agent. The effect of curcumin on
serum
copper, zinc, and zinc/copper ratio in patients with β-thalassemia
intermedia:
a randomized double-blind clinical trial Annals of Hematology |
February
2021
Due to its significant therapeutic effects, curcumin has led many
studies to
focus on curcumin. Curcumin might exert a net protective effect on
copper
toxicity in thalassemia intermedia patients. The investigation also
implicated
that curcumin represents an approach to regulating zinc homeostasis and
may be
useful as a complementary treatment of patients with thalassemia
intermedia,
especially in patients with zinc deficiency or low serum zinc/copper
ratio.
Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in
mice by
activating the PPARα signaling pathway Elife | February
2021
Curcumin is a polyphenol compound that exhibits multiple physiological
activities. Curcumin, a polyphenol compound, is extracted from the
rhizome of
Curcuma longa and has a long history of use in traditional medicines.
In in
vitro experiments, curcumin has been shown to suppress the aggregation
and
cytotoxicity of Aβ, αSyn, islet amyloid precursor protein (IAPP),
ATTR and
prion protein (PrP). In
2001
, the first evidence of the efficacy of curcumin against Aβ
amyloidosis in a
transgenic model mice was reported. Curcumin was found to suppress
amyloid
deposition in a mouse model of Alzheimer's disease and improve memory
function.
It was subsequently demonstrated that the amount of amyloid present in
TTR-and
tau-transgenic mice were reduced by curcumin supplementation. Curcumin
is a
compound with multiple physiological activities, which includ
eanti-oxidation,
anti-inflammatory, anti-cancer, lipid metabolism regulation and
anti-amyloid
properties. Curcumin and Metabolic Diseases: The Role of Gut Microbiota
Nutrients | January
2021
Turmeric, also known as Curcuma longa L. belongs to Zingiberaceae (or
ginger
family) and is a golden-colored spice. Curcumin
((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)
is the
principle curcuminoid of turmeric used in traditional medicine to cure
various
kinds of malady, as well as being a food additive and coloring agent in
Asian
cuisines and in beverage industries. Hewlings and Kalman stated the
beneficial
effects of curcumin in the treatment of chronic diseases, such as
gastrointestinal, neurological disorders, cardiovascular disease,
diabetes, and
several types of cancer. Enzymes of the large intestine metabolise
curcumin,
and it is carried out in two phases. In phase-1 metabolism, it yields
three
metabolites, 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
(tetrahydrocurcumin),
5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone
(hexahydrocurcumin), and
1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol
(octahydrocurcumin) under reduction. After that, curcumin and its
metabolites
subject to conjugation through phase-II metabolism to yield sulfate and
glucuronide O-conjugated metabolites. Curcumin metabolites have
properties and
potency similar to curcumin and exhibit the same physiological and
pharmacological properties. It has been stated that curcumin and gut
microbiota
have bidirectional interactions such as gut microbiota regulation by
curcumin
and biotransformation of curcumin by gut microbiota. Carmody et al
reported
that the biological properties of curcumin depend on the activity of
metabolites produced by gut microbiota digestion. The curcumin
metabolic
pathways by GM include reduction, methylation, demethoxylation,
hydroxylation,
and acetylation, and the main products are
1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
(tetrahydrocurcumin),
3-(4-Hydroxy-3-methoxyphenyl)propanoic acid (dihydroferulic acid), and
1-(4-hydroxy-3-methoxyphenyl)-2-propanol. Furthermore, curcumin can
also be
metabolized by Pichia pastoris into four major metabolites, include
1,7-bis(4-hydroxy-3methoxyphenyl) heptan-3,5-diol,
5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl) heptan-3-one,
5-hydroxy-1,7-bis(4-hydroxyphenyl) heptane-3-one, and
5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)
heptan-3-one
[101,103]. Many GM, such as E. coli, E. fergusonii (ATCC 35469) Blautia
sp.
(mrg-pmf1), Bifidobacterium (Bifidobacteria longum BB536,
Bifidobacteria
pseudocatenulaum G4), Lactobacillus (Lactobacillus casei and
Lactobacillus
acidophilus), Enterococcus faecalis JCM 5803, Pichia anomala, and
Bacillus
megateriumdcmb-002, are found biologically relevant in the
biotransformation
and degradation of curcumin. Curcumin, a traditional spice component,
can hold
the promise against COVID-19? European Journal of Pharmacology |
January
2021
Curcumin, known for its pharmacological abilities especially as an
anti-inflammatory agent, can be hypothesized as a potential candidate
in the
therapeutic regimen. COVID-19 has an assorted range of
pathophysiological
consequences, including pulmonary damage, elevated inflammatory
response,
coagulopathy, and multi-organ damage. This review summarizes the
several
evidences for the pharmacological benefits of curcumin in
COVID-19-associated
clinical manifestations. Curcumin can be appraised to hinder cellular
entry,
replication of SARS-CoV-2, and to prevent and repair
COVID-19-associated damage
of pneumocytes, renal cells, cardiomyocytes, hematopoietic stem cells,
etc. The
modulation and protective effect of curcumin on cytokine storm-related
disorders are also discussed. Collectively, this review provides
grounds for
its clinical evaluation in the therapeutic management of SARS-CoV-2
infection.
The combination of bromelain and curcumin as an immune-boosting
nutraceutical
in the prevention of severe COVID-19 Metabolism | January
2021
The antiviral actions of curcumin against multiple viruses (influenza
and
hepatitis viruses, herpes viruses, human papilloma virus, human
immunodeficiency virus, severe acute respiratory syndrome coronavirus
and other
coronaviruses), bacteria and fungi have been established by
experimental
evidence. Remarkably, recent evidence from in silico studies has
demonstrated
that curcumin prevents SARS-CoV-2 entry into cells by blocking the
viral
binding sites and the cell ligands (spike protein, ACE-2 receptors and
basigin), downregulating trans-membrane serine protease 2 (TMPRSS-2),
and by
interfering with viral replication through the interaction with various
viral
proteins Curcumin (diferuloylmethane) is a natural phenol found in
turmeric
(Curcuma longa), a member of the ginger family of plants. Curcumin
modulates
inflammation preventing the subsequent cytokine storm by inhibiting
multiple
transcription factors such as nuclear factor kappa B (NF-κB) and
signal
transducer and activator of transcription 3 (STAT-3), and
downregulating the
proinflammatory cytokines, as this has been demonstrated in human
macrophages
after influenza virus infection. Additionally, curcumin inhibits ACE
modulating
angiotensin II synthesis and downregulating inflammation, while it also
promotes fibrinolysis and the anticoagulation process. Notably,
bromelain
substantially increases the absorption of curcumin after oral
administration.
To the best of our knowledge, this is the first report highlighting the
significance of bromelain and, most importantly, the potential
preventive value
of the synergistic effects of bromelain and curcumin against severe
COVID-19.
The potential anti-cancer properties of curcumin in liver cancer In
Vivo |
January
2021
Curcumin is a polyphenol that exerts a variety of pharmacological
activities
and plays an anti-cancer role in many cancer cells. Curcumin increased
the
expression of the GSDME N-terminus and proteins involved in pyrolysis,
promoted
HspG2 cell pyrolysis and increased intracellular ROS levels. Moreover,
inhibition of the production of intracellular ROS with n-acetylcysteine
(NAC)
improved the degree of apoptosis and pyrolysis induced by curcumin.
Curcumin
induces HspG2 cell death by increasing apoptosis and pyroptosis, and
ROS play a
key role in this process. This study improves our understanding of the
potential anti-cancer properties of curcumin in liver cancer. The role
of
curcumin, a potent constituent of turmeric in pleiotropic health
beneficial
effects Journal of Biologically Active Products from Nature | January
2021
Curcumin (1,6- heptadiene- 3,5 - dione- 1,7 - bis
(4-hydroxy-3-methoxyphenyl) -
(1E,6E) or diferuloylmethane), isolated from Curcuma longa, is a highly
promising natural compound that has several health benefits.
Supplementation of
curcumin provided significant (p < 0.05) protection against
HgCl2 induced
alterations by ameliorating the levels of ROS, PCO, SA, and -SH in
erythrocytes
membrane and plasma. Thus, the curcumin protects against HgCl2 induced
oxidative stress. It also provides an insight into the role of
curcumin, a
potent constituent of turmeric in pleiotropic health beneficial
effects.
Curcumin, the primary active ingredient in turmeric, reportedly exerts
potent
antifibrotic effects Basic & Clinical Pharmacology & Toxicology
| January
2021
These results indicate that curcumin is a promising treatment agent for
RIF,
and its antifibrotic effects may be mediated by the inhibition of NLRP3
inflammasome activity through the regulation of autophagy and
protection of
mitochondrial function in UUO rats. Curcumin Suppresses Cell Growth
Life
Sciences | January
2021
Curcumin induced Ac-p53 and p21 to suppress cell proliferation.
Curcumin
increased p-Akt and attenuated fluoride-mediated apoptosis and DNA
damage.
Curcumin suppressed fluoride-induced p-p21 and increased p21 in the
nuclear
fraction. Dichloroacetic acid-induced dysfunction in rat hippocampus
and the
protective effect of curcumin Metabolic Brain Disease | January
2021
Various doses of curcumin attenuated DCAA-induced oxidative stress,
inflammation response and impaired synaptic plasticity, while elevating
cAMP,
PKA, p-CREB, BDNF, PSD-95, SYP levels. Thus, curcumin could activate
the
cAMP-PKA-CREB signaling pathway, conferring neuroprotection against
DCAA-induced neurotoxicity. Curcumin protects radiation-induced liver
damage in
rats through the NF-κB signaling pathway Complementary Medicine and
Therapies
| January
2021
Curcumin has been demonstrated to exert anti-oxidant, anti-fibrotic,
anti-inflammatory, and anti-cancer activities. Our study highlights
that
curcumin treatment reduces the liver damage caused by radiation through
the
inhibition of the NF-κB pathway. Curcumin, as a good all-natural drug
for the
treatment of IBD, possesses good prospects in clinical application
Molecular
Medicine Reports | January
2021
Curcumin is an all-natural compound extracted from plants. It has many
biological activities including anti-inflammatory, anti-infective and
immune-regulating, and it protects the intestinal mucosa and repairs
the
function of intestinal tissue. Other similar studies have shown that in
the
DSS-induced colitis model, curcumin is found to significantly improve
intestinal inflammation, repair the intestinal mucosa and inhibit the
expression of TNF-α and p38MAPK. Curcumin itself has anti-inflammatory
and
anti-infective effects. At the same time, curcumin can reduce and
inhibit the
exudation of neutrophils and macrophages, regulate intestinal immune
disorders,
reduce intestinal endothelial cell swelling and increase permeability,
which
further reduces intestinal inflammation. Curcumin can significantly
decrease
the DAI and SI of the mice with colitis. Curcumin, as a good
all-natural drug
for the treatment of IBD, possesses good prospects in clinical
application.
Effect of Curcumin on Triple-Negative Breast Cancer AIP Conference
Proceedings
| January
2021
Curcumin has been reported to efficiently inhibit cancer cell lines,
including
MCF7, K562, HeLa,and 4T1. Previous study of curcumin on 4T1 breast
cancer cells
showed that the IC50 values were 93,14 μM. The main mechanisms of
action by
which curcumin exhibits its 040024-2 unique anti-cancer activity
include
inducing apoptosis and inhibiting proliferation, invasion, and
metastasis of
tumors by suppressing a variety of cellular signaling pathways. Several
research on various breast cancer cell lines demonstrate the
anti-cancer
activity of curcumin through the inhibition of NF-κB activity.
Curcumin, the
yellow pigment isolated from turmeric, has been reported to suppress
NF-κB.
Several studies reported that curcumin inhibits NF-κB through
inhibition of
IKK phosphorylation and inhibition of translocation to the nucleus.
Curcumin
selectively inhibits NF-κB p105 mRNA expression on 4T1 breast cancer
cell line
by interacting with the backbone of Ile residue in RH domain region.
This study
highlights the potency of curcumin to be developed as a
chemotherapeutic
targeted NF-κB for triple-negative breast cancer in the future.
Curcumin has a
certain antagonized effect on cardiac arrhythmia and has potential
application
prospects Frontiers in Physiology | January
2021
Curcumin is a natural yellow polyphenolic substance, the main active
alkaloid
extracted from the rhizome of turmeric, a rhizomatous herbaceous
perennial
plant belonging to the family Zingiberaceae, which has been used as an
antiseptic and antipyretic folk medicine for centuries. Previous
researches
have shown that curcumin has extensive pharmacological activities and
has been
put into clinical practice. Increasing evidence showed that curcumin
has a
protective effect against cardiovascular disease. For instance,
curcumin can
prevent the development of heart failure by inhibiting p300 histone
acetyltransferase activity, antagonized sodium fluoride intoxication in
rat
heart, prevented isoprenaline (ISO)-induced cardiac hypertrophy, and
can have a
protective effect against the myocardial infarction injury. In
addition,
curcumin was reported to prevent the QTc prolongation in ISO-induced
myocardial
infarction. Curcumin is also a multi-ion channel blocker that inhibits
ICa.L
and IKr and preferentially blocks INa.L, shortens APD, suppresses EADs
and DADs
at the cellular level, prevents I/R-induced arrhythmia at the organ
level, and
may have potential antiarrhythmic property. Curcumin can prevent the
occurrence
of arrhythmias after reperfusion, which is beneficial for the recovery
of
isolated heart suffering from I/R injury. New evidence for the
potential
anti-inflammatory and cardiovascular protective effects of curcumin
Evidence-Based Complementary and Alternative Medicine | January
2021
Curcumin is the most active component of spice turmeric (also called
curry
powder), mainly found in turmeric roots (Curcuma longa L.). It has long
been
studied for its antioxidant, anti-inflammatory, antimutagenic,
antimicrobial,
and anticancer properties. In the recent years, curcumin has been
extensively
investigated for its therapeutic value. Its anti-inflammatory effect
which is
equivalent to that of steroidal and nonsteroidal drugs, e.g.,
indomethacin and
phenylbutazone, is one of the most studied properties. In various
inflammation-related chronic illnesses such as cardiovascular disease,
cancer,
diabetes, and obesity, curcumin has shown good therapeutic effects. The
present
study shows that curcumin suppresses aldosterone-induced CRP generation
in
VSMCs by interfering with the ROS-ERK1/2 signaling pathway. These
results
reveal a mechanism through which curcumin represses inflammation and
confers
cardiovascular protection. Our findings further confirm the
anti-inflammatory
and cardiovascular protective effects of curcumin and suggest its
potential
clinical use in cardiovascular inflammation. Curcumin may be an
attractive
natural candidate for further investigation and development in the
quest for
Parkinson's disease therapeutics International Journal of Molecular
Sciences |
January
2021
The polyphenolic ingredient of dietary turmeric (Curcuma longa),
curcumin, has
attracted attention due to its multiple benefits to patients with
various
diseases including Parkinson's disease. Several studies have
demonstrated that
curcumin treatment significantly inhibits the toxin-induced loss of
dopaminergic neurons in both cultured cells and animal models. Curcumin
was
found to exert neuroprotective effects mediating anti-oxidant,
anti-inflammatory, and anti-apoptotic properties and improve
neurological
functions in various animal models of Parkinson's disease. Our results
demonstrated that intragastric curcumin treatment (200 mg/kg)
significantly
improved the abnormal motor behavior and offered neuroprotection
against the
reduction of dopaminergic neurons, as determined by tyrosine
hydroxylase (TH)
immunoreactivity in the substantia nigra and caudoputamen. In
conclusion, this
study demonstrates that curcumin has a neuroprotective effect in a
6-hydroxydopmine (6-OHDA) rat model of PD via an α7-nAChR-mediated
mechanism.
The findings of the present study demonstrate that curcumin improves
the
survival of TH striatal fibers and neurons in SNpc and diminishes
abnormal
turning behavior in a 6-OHDA-induced rat model of PD. In the present
study,
abrogation of the protective effects of curcumin by pretreatment with
MLA, an
α7-nAChR-selective antagonist, clearly demonstrates that
neuroprotective
effects of curcumin are mediated by α7-nAChRs. Our findings clearly
demonstrate that α7-nAChRs may be an attractive therapeutic target for
PD and
curcumin appears to be the first agent of natural origin to modulate
α7-nAChRs
in PD. Integrating our earlier observation that curcumin acts as a type
II PAM
of α7-nAChRs and potentiates receptor function by significantly
decreasing
desensitization, it is apparent that the PAM action of curcumin on
α7-nAChRs
exerts beneficial effects in mediating neuroprotective effects.
Time-tested
safety and neuroprotective efficacy of curcumin and preliminary
clinical
success of agents targeting nicotinic receptors in Parkinson's disease.
Curcumin and NAC may be effective against noise-induced hearing loss
Indian
Journal of Otolaryngology and Head & Neck Surgery | January
2021
We investigated the effectiveness of N-acetyl cysteine (NAC) and
curcumin,
which have known antioxidant and anti-inflammatory effects, in reducing
acoustic trauma. There was a statistically significant difference in
the third
measurements in both groups 2 and 3, possibly due to curcumin and NAC
treatment. This study showed that curcumin and NAC may be effective
against
noise-induced hearing loss. Curcumin exhibits beneficial effect on bone
fracture healing Medical Science Monitor | January
2021
Curcumin has been used for a very long time in traditional medicine
because of
several pharmacological properties. Multiple properties of curcumin
include its
role as an anti-inflammatory, antioxidant, and anti-fibrotic agent.
Additionally, studies have shown tumor growth inhibitory effect and
myocardial
injury protecting property of curcumin. Although studies on the use of
curcumin
in bone trauma treatment are limited, reports suggest that curcumin may
have a
positive effect in bone remodeling. The current study investigated
curcumin for
bone trauma treatment in a rat model and evaluated the related
mechanism.
Curcumin activates autophagy and inhibits mTOR activation in bone
tissues of
rats with trauma. The curcumin promoted myeloid-derived suppressor cell
(MDSC)
proliferation and increased expansion of MDSCs in a rat model of
trauma.
Therefore, curcumin may have beneficial effect in patients with bone
trauma and
should be evaluated further for development of treatment. A novel
application
of curcumin in tumor therapy Archives of Biochemistry and Biophysics |
January
2021
Curcumin promotes cancer-associated fibroblasts apoptosis via
ROS-mediated
endoplasmic reticulum stress. Curcumin is a natural polyphenol derived
from
turmeric, which has been shown to inhibit the growth of many types of
tumor. We
found that curcumin induced the apoptosis and cell cycle arrest of
CAFs, which
is mainly caused by the ROS-mediated endoplasmic reticulum stress
pathway. Our
study suggests that curcumin selectively inhibits prostate-CAFs by
inducing
apoptosis and cell cycle arrest in G2-M phase, indicating a novel
application
of curcumin in tumor therapy. Curcumin may be an alternate to
antimicrobial
drugs for the therapeutic management of endometritis Molecular Biology
Reports
| January
2021
Curcumin inhibited the basal and LTA+LPS induced production of PGE2 and
upregulation of PIC production. It was apparent that LPS, but not LTA,
is a
potent stimulator of PGE2 from the bubaline endometrial stromal cells.
Curcumin
downregulated the expression of LPS and/or LTA induced PICs and PGE2
and may be
an alternate to antimicrobial drugs for the therapeutic management of
endometritis. Curcumin represents a promising therapy for Diabetes
mellitus
induced cognitive impairments and memory deficits Neurobiology of
Disease |
January
2021
Curcumin, derived from the rhizome of Curcuma longa Linn, is a bright
yellow
spice that shows strong anti-inflammatory, anti-oxidant, and anti-tumor
activities.ibiting neuroinflammation. We demonstrated that curcumin
attenuated
DM/CCH-induced cognitive defcits and hippocampal neuronal damage in
rats, and
that its underlying mechanisms were associated with inhibiting
neuroinflammation, regulating the TREM2/TLR4/NF-κB pathway,
suppressing
excessive apoptosis, and mitigating NLRP3-dependent pyroptosis. These
findings
suggest that curcumin may be useful as a pharmacological strategy for
ameliorating Diabetes mellitus /CCH-induced memory deficits. Curcumin
exhibited
renoprotective, antioxidant, anti-inflammatory properties, especially
curcumin
exerted the most pronounced effect as an anti-inflammatory and
anti-apoptotic
reflecting its powerful effect against bacteria and sepsis-induced
kidney
injury Future Journal of Pharmaceutical Sciences | January
2021
Curcumin a polyphenol extracted from turmeric gained interest as a
potentially
safe and inexpensive treatment for kidney diseases. Inflammatory
markers were
greatly reduced by both curcumin and propolis, only curcumin
pretreatment
attenuated NF-kB activation in kidney tissue of septic rat. The
protective
effect of curcumin on ACR-intoxicated brains BMC Pharmacology and
Toxicology |
January
2021
Curcumin is well known for its classic and strong anti-oxidative and
anti-inflammatory activities. As the most active constituent in
turmeric, a
common spice, with a strong safety record, curcumin has been considered
to be a
potential natural neuroprotective agent under limelight. Based on its
known
antioxidant, anti-inflammatory and anti-apoptosis activities, curcumin
has been
shown to protect the neurons against cerebral ischemia-reperfusion
injurye
neuroprotective effect of curcumin in an ACR model of
neurotoxicity in an
insect species, Drosophila melanogaster. A recently published study
reported
that curcumin would exert a protective effect against ACR-induced
spatial
memory impairment in rats. The phenolic structure in curcumin confers
electron-capturing properties, which destabilize ROS, explaining the
well-accepted antioxidant effects. Curcumin alleviated the augmented
production
of MDA and the reduction of antioxidant capacity induced by ACR, thus
might
play a role in the detoxification of reactive oxygen species generated
by ACR.
Curcumin could improve the ACR-induced neuroinflammation, which was in
accord
with its proven anti-inflammatory property. Curcumin: Could This
Compound Be
Useful in Pregnancy and Pregnancy-Related Complications? Nutrients |
January
2021
Curcumin, the main polyphenol contained in turmeric root (Curcuma
longa), has
played a significant role in medicine for centuries. The pleiotropic
and
multi-targeting actions of curcumin have made it very attractive as a
health-promoting compound. In spite of the beneficial effects observed
in
various chronic diseases anti-inflammatory, antioxidant, antitoxicant,
neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic,
anti-hypertensive, and antidiabetic properties of curcumin appear to be
encouraging, not only for the management of pregnancy-related
disorders,
including gestational diabetes mellitus (GDM), preeclampsia (PE),
depression,
preterm birth, and fetal growth disorders but also to contrast damage
induced
by natural and chemical toxic agents. Curcumin, a compound extracted
from the
rhizome of Curcuma longa, has been extensively studied in light of a
wide range
of properties, including anti-inflammatory, antioxidant, anti-toxicant,
antiapoptotic, immunomodulatory, neuroprotective, hepatoprotective,
antiangiogenic, anti-hypertensive, and antidiabetic activities,
emerging as a
candidate therapeutic agent for several diseases. Curcumin, also called
diferuloylmethane, is a lipophilic polyphenol extracted from the
rhizome of
Curcuma Longa (commonly known as turmeric). It has been widely used in
traditional Indian and Chinese medicine for thousands of years. The
pharmacological effects of turmeric have been attributed mainly to
curcuminoids, comprising curcumin and two related compounds,
demethoxycurcumin
and bisdemethoxycurcumin, which are contained in commercial curcumin.
Curcumin
is a potent anti-inflammatory and antioxidant agent that exerts a
myriad of
biological activities by influencing multiple signaling pathways.
Curcumin is
able to interact with a large number of molecular and cellular targets
and
regulates gene expression also by modulating epigenetic modifications
(i.e.,
DNA methylation, histone modification, and microRNA expression). This
compound,
by mutually interacting with intestinal microflora Curcumin extract
eased pain,
stiffness and physical function in those with osteoarthritis of the
knee New
York Times | December
2020
Turmeric comes from the root of a plant in the ginger family, Curcuma
longa,
and contains a chemical compound, curcumin, that has long been used in
traditional Chinese and Indian medicine. In a 12-week randomized,
double-blind,
placebo-controlled trial, researchers assigned 70 people with
symptomatic knee
osteoarthritis to take either two capsules a day of a Curcuma longa
extract or
two capsules of an identical-looking placebo. They found that pain,
stiffness
and physical function all improved significantly more in those who took
the
curcumin extract than in those who used the placebo. Neonatal curcumin
treatment restores hippocampal neurogenesis and improves autism-related
behaviors in a mouse model of autism Psychopharmacology | December
2020
Curcumin has been indicated to be neuroprotective against neurological
and
psychological disorders. Neonatal curcumin treatment improved
autism-related
symptoms in BTBR mice, enhancing sociability, reducing repetitive
behaviors,
and ameliorating cognitive impairments. Furthermore, the suppression of
hippocampal neurogenesis in BTBR mice was greatly rescued after
neonatal
curcumin treatment, leading to an increase in neurogenic processes and
an
increase in NPC proliferation concomitant with an expansion of the NPC
pool on
P8, and NPC differentiation towards the neuronal lineage was promoted
in the DG
of BTBR mice on P24. Our findings suggest that neonatal curcumin
treatment
elicits a therapeutic response through the restoration of hippocampal
neurogenesis in BTBR mice and thus may represent a promising novel
pharmacological strategy for ASD treatment. Curcumin cooperates with
anticancer
drugs The International Journal of Biochemistry & Cell Biology |
December
2020
Curcumin inhibit Lactate-induced onset of chemoresistance through
modulation of
HCAR-1. Curcumin modulates Chromatin condensation and acidification of
extracellular milieu of cancer cells. Can Turmeric Help With Knee
Arthritis San
Diego Orthobiologics | December
2020
Turmeric, a spice from South Asia derived from the Curcuma longa root,
has been
used as a medicine for nearly 4000 years. Recent studies have shown
that
turmeric may help to relieve joint pain caused by arthritis because the
active
ingredient, curcumin, is now known to have anti-inflammatory
properties.
Curcumin has been shown to have similar efficacy to diclofenac, a
non-steroidal
anti-inflammatory drug, with fewer side effects. Similar improvements
in pain
severity and function were seen with curcumin and diclofenac in a
randomized,
controlled clinical study of 139 patients with knee osteoarthritis.
Nineteen
patients in the diclofenac group (and none in the curcumin group)
required
anti-ulcer medications at 28 day followup. Curcumin has also been shown
to have
a strong antioxidant capacity. In a randomized double-blind
placebo-controlled
trial, patients with mild-to-moderate knee osteoarthritis were given
the
curcuminoid and were compared to a group that received a placebo for 6
weeks.
Researchers measured the levels of enzymes known to influence
inflammation
(e.g. superoxide dismutase (SOD) and malondialdehyde (MDA)). The
treatment
group showed significant changes in these enzymes suggesting that
short-term
supplementation with curcumin decreases oxidative stress. 5 Good Things
About
Turmeric MD News Daily | December
2020
A report about turmeric indicates that study in the European Review for
Medical
and Pharmacological Studies, Frontiers in Pharmacology, and Endocrine,
Metabolic & Immune Disorders Drug Targets associate curcumin with
weight loss
and reduction in body mass index or BMI. Healthy cooking expert and
registered
dietitian Patricia Bannan said, while increasing our turmeric intake
alone is
not a great tactic in losing weight, it may contribute to the
mitigation of
inflammation linked to obesity and offer a slight boost in fat burning.
Curcumin may help protect from inflammation, and inflammation may help
in
fighting depression. A
2019
meta-analysis of 10 studies of curcumin and depression published in
Critical
Reviews in Food Science and Nutrition proposed that it could alleviate
depression and anxiety symptoms. Experts say the most available study
specifies
that curcumin may help lessen the depression symptoms in individuals
who are
already using an antidepressant. Previous studies on animals propose
that there
might be a link between the inflammation-calming action of curcumin in
turmeric
and cancer. Specifically, Bannan said, curcumin is believed "to have
antioxidant properties." Meaning, it may reduce both swelling and
inflammation.
Nevertheless, research on animals does not always translate humans.
Research
for curcumin continues, as well as its effect on cancer in people. A
study
finds people living in India have lower rates of developing Alzheimer's
disease
than those living in the United States and Europe. The reasons for the
difference, the study authors said, are complex and possibly because of
several
different factors. Typically, turmeric is used in Ayurveda, a holistic
healing
mechanism that originated in India thousands of years back and remains
famous
to date. Turmeric is also prominent in Indian cuisine, bringing out the
question of whether it is possible that this spice can contribute to
the
prevention or delay of onset of Alzheimer's. The jury, according to the
study,
is still out. However, one theory presents, curcumin may contribute to
the
inhibition of plaques that other studies have linked to "neuron
impairment in
the brain. Based on a report by the Centers for Disease Prevention and
Control,
more than 100 million adults in the US have developed either
prediabetes or
diabetes. A study on curcumin, which the Journal of Nutrition &
Intermediary
Metabolism published, proposes that it can function as a "hypoglycemic
agent,"
reducing and helping regulate blood sugar levels in people who have
type 2
diabetes, CDC said. Anti-inflammatory effects of oral supplementation
with
curcumin: a systematic review and meta-analysis of randomized
controlled trials
Nutrition Reviews | December
2020
Chronic inflammation is a major contributor to the development of
noncommunicable diseases. Curcumin, a bioactive polyphenol from
turmeric, is a
well-known anti-inflammatory agent in preclinical research. Clinical
evidence
remains inconclusive because of discrepancies regarding optimal dosage,
duration, and formulation of curcumin. These findings provide evidence
for the
anti-inflammatory effects of curcumin and support further investigation
to
confirm dose, duration, and formulation to optimize anti-inflammatory
effects
in humans with chronic inflammation. Quinacrine and curcumin
synergistically
increased breast cancer stem cells death Cancer Biology and Therapeutic
Oncology | December
2020
Curcumin and QC synergistically inhibited the proliferation, migration
and
invasion of CSCs enriched side population (SP) cells of cigarette smoke
condensate induced breast epithelial transformed (MCF-10A-Tr) generated
metastatic cells. Curcumin + QC combination increased the DNA damage
and
inhibited the DNA repair pathways in SP cells. Uptake of QC increased
in
Curcumin pre-treated SP cells and this combination inhibited the ABCG2
activity
by the reduction of ATP hydrolysis in cells. In vitro DNA binding
reconstitution system suggests that QC specifically binds to DNA and
caused DNA
damage inside the cell. Decreased level of ABCG2, representative cell
survival
and DNA repair proteins were noted after Curcumin + QC treatment in SP
cells.
Longevity-Promoting Herb Well and Good | December
2020
In
2018
, Dr. Small authored a small double-blind study showing that taking two
90 mg
curcumin supplements daily for 18 months improved memory and attention
in older
adults with mild memory problems. “We did find it has a significant
effect…compared to placebo,†says Dr. Small, who is currently
expanding the
research to a much larger sample size across the U.S. While he’s not
sure
exactly how curcumin works to boost brain health, “my best guess is
it’s
the reduction in inflammation,†he says. Robinette points out that
turmeric
has been called a “natural immunomodulator,†or a substance that
helps keep
the immune system in check by boosting immunity when you need it and
tamping it
down to prevent excess inflammation involved in many chronic
conditions. Some
research suggests that turmeric could potentially even play a role in
preventing and treating cancer, cardiovascular disease, metabolic
conditions,
neurological disease, and skin diseases. Although it certainly
doesn’t hurt
to enjoy more foods with turmeric, you’ll need to pop a curcumin
supplement
to get the full health benefits of the spice. “For therapeutic
purposes, you
want to take higher doses,†says Robinette. Try to take the
supplement when
you eat your meals, preferably with fat (like fatty fish or nuts) to
increase
the bioavailability of curcumin. Antitumor effects of curcumin in
pediatric
rhabdomyosarcoma International Journal of Oncology | December
2020
Curcumin (CUR) is a promising drug in complementary oncology with few
side
effects but proven efficacy in various adult oncological entities. The
present
study analyzed the effects of curcumin on pediatric (RMS) cell lines in
vitro.
Curcumin decreased cell viability in all assessed RMS cell lines in a
concentration‑dependent manner with IC50=14‑20 µM. Curcumin
enhanced the
effects of the cytotoxic drugs VCR or DAC, and led to reduced migration
and
increased cell apoptosis. In combination with PDT, curcumin decreased
the cell
viability in minute quantities with up to a 10‑fold lower IC50 than
without
PDT. Curcumin effectively inhibited the malignant properties of
pediatric RMS
cells and should be focused on as a useful additional agent in standard
chemotherapy of RMS in children. Curcumin in antidepressant treatments
Basic &
Clinical Pharmacology & Toxicology, December
2020
Curcumin, a natural compound derived from the herb Curcuma longa,
exhibits a
wide range of pharmacological properties and has been considered a
potent
antidepressant drug with diverse mechanisms including monoaminergic
imbalances
(associated with serotonin, dopamine, noradrenaline and glutamate),
effect on
neurotransmitters, neuroprogression, the
hypothalamicâ€pituitaryâ€adrenal
(HPA) axis disturbances, dysregulated inflammation and immune pathways,
oxidative and nitrosative stress, and mitochondrial disturbances. In
this
review, multiple potential mechanisms of curcumin for treating
depression
demonstrated in either animal or human studies are summarized. Curcumin
Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human
Tenocytes
in Vitro Journal of Biological Chemistry, December
2020
Inflammatory processes play essential roles in the pathogenesis of
tendinitis
and tendinopathy. Results demonstrate, for the first time, a potential
role for
curcumin in treating tendon inflammation. Curcumin in Depression:
Potential
Mechanisms of Action and Current Evidence Frontiers in Psychiatry |
March
2021
Curcumin is the main active component in the spice turmeric that has
been used
for centuries in Ayurvedic medicine to treat a variety of conditions,
including
anxiety and depressive disorders. In the past decades, curcumin has
drawn
researchers' attention and displays a broad range of properties that
seem
relevant to depression pathophysiology. Curcumin has displayed, in a
number of
studies, a potency in modulating neurotransmitter concentrations,
inflammatory
pathways, excitotoxicity, neuroplasticity,
hypothalamic–pituitary–adrenal
disturbances, insulin resistance, oxidative and nitrosative stress, and
endocannabinoid system, all of which can be involved in MDD
pathophysiology. To
date, a handful of clinical trials have been published and suggest a
benefit of
curcumin in major depressive disorder. With evidence that is
progressively
growing, curcumin appears as a promising alternative option in the
management
of major depressive disorder. Turmeric (Curcuma longa) is a yellow
spice, part
of the ginger family (Zingiberacear). It has been empirically used for
centuries in Ayurvedic and traditional Chinese medicine in a wide
variety of
diseases and conditions. Research conducted in the last half century
has
revealed that the active compounds of turmeric were curcuminoids, which
are
polyphenolic pigments that give turmeric its yellowish color. Curcumin
is the
primary curcuminoid and main active component in turmeric and the
compound for
which most studies have been done. In the past decades, there has been a
surge
of interest in curcumin as evidence about its efficacy in a wide
variety of
diseases is growing, including cardiovascular, autoimmune, and
neurodegenerative diseases as well as diabetes and cancers. Thus,
curcumin
displays a broad range of properties that are relevant in the
pathophysiology
of depression. It has been demonstrated to possess an antidepressant
activity
in various animal models as well as in clinical trials. A dozen
randomized
controlled clinical trials have indeed been conducted, altogether
suggesting
that curcumin may be effective as a treatment (or adjunct treatment) of
depression via multiple mechanisms of action. Anticancer properties of
curcumin: a novel natural inhibitor of rDNA transcription Cell Cycle |
November
2020
Curcumin treatment impairs the assembly of the RNA polymerase I
preinitiation
complex at rDNA promoters and represses rDNA promoter activity, which
leads to
the decrease of rRNA synthesis. In addition, curcumin treatment
stimulates
autophagosome formation and promotes autophagic degradation in cells.
Mechanistically, curcumin inactivates the mechanistic target of
rapamycin
complex 1 (mTORC1), the upstream regulator of rDNA transcription and
autophagy
induction, by inhibiting mTOR lysosomal localization. Functionally,
curcumin
treatment inhibits protein synthesis, cell growth and cell
proliferation. Taken
together, these findings identify curcumin as an effective inhibitor of
rDNA
transcription and provide novel mechanisms for the anticancer
properties of
curcumin. Reduce Your Lifetime Risk of Breast Cancer The Beet |
November
2020
Curcumin lowers inflammation, which can lower the risk of breast
cancer.
Curcumin, the main active ingredient in turmeric, is known for
relieving
inflammation and pain but also for having an effect on lowering the
risk of
breast cancer. A study found "curcumin has chemopreventive and
antitumoral
activities against some aggressive and recurrent cancers," the study
said.
Another study found curcumin not only stops tumor growth but also
prevents
malignant cancers from spreading: The "anticancer effect" of curcumin
relates
to the fact that it appears to half "cell cycle and proliferation," as
well as
"cancer spread and angiogenesis," the study says, which is how the body
supplies new blood vessels to a tumor. Curcumin against Prostate
Cancer:
Current Evidence Biomolecules | November
2020
The available in vitro studies have shown that curcumin is able to
inhibit
viability, proliferation, survival, migration/invasion, and adhesion of
various
human prostate cancer cells. Curcumin inhibited both androgen-sensitive
and
-insensitive prostate cancer cells by targeting a number of signaling
cascades
responsible for regulating cellular function. The antiproliferative,
antisurvival, and antimigratory effects of curcumin in prostate cancer
cells
may be due to the inhibition of the Akt/mTOR, Ras/MAPK signaling
pathways,
decreased NF-κB activation, enhanced proapoptoptic caspase and PARP
cleavage,
and the inhibition of members of the antiapoptotic Bcl-2 family of
proteins.
Curcumin was also able to induce cell-cycle arrest and enhance
autophagy in
various prostate cancer cell lines. The available in vivo studies have
shown
that curcumin administration is able to inhibit the growth/volume,
formation,
development, proliferation, and angiogenesis of prostate cancer tumors
while
promoting apoptosis. These effects were observed in mice xenografted
with both
androgen-sensitive and insensitive prostate cancer cells. Curcumin’s
inhibition of prostate tumor growth and progression may be due to its
inhibition of Akt expression/activation, decreased NF-κB activation,
inhibition of the anti-apoptotic proteins Bcl-2 and Bcl-xL, increased
expression of the proapoptotic proteins Bax and Bak, and enhanced PARP
and
caspase expression. These findings from in vivo studies are in
agreement with
those from the in vitro studies. The downregulation of cell
proliferation,
paired with the enhanced activity of programmed cell death both in
vitro and in
vivo, render curcumin an ideal candidate for the development of novel
anticancer pharmaceutical agents providing fewer detrimental effects
due to its
low toxicity. Metabolites of curcumin and their therapeutic effects
Cell |
November
2020
Curcumin, a secondary metabolite from the turmeric plant is one of the
most
promising natural products, which has been studied extensively for
decades. It
has demonstrated several pharmacological activities in vitro and in
vivo.
Several diverse therapeutic effects have shown to be exhibited by
reduced
metabolites of curcumin such as antioxidant, anti-cancerous,
anti-inflammatory
and immunoregulatory activities. Curcumin is a natural polyphenolic
compound
which forms a majorcomponent of rhizomes from dietary spice turmeric
(Curcuma
longaa plant belongs to Zingiberaceae family. It is commonly used as a
flavouring agent in various foods and also as a traditional medicinal
agent. In
several studies, curcumin have shown a diverse range of pharmacological
effects
like, anti-cancer, anti-oxidation, anti-inflammatory, anti-bacterial
activities, free radical scavenging and anti-depression. Owing to these
pharmacological effects, curcumin has therapeutic potential over a
variety of
human diseases such as cancer, cardiovascular disease, diabetes,
arthritis,
Alzheimer's disease, AIDS, neurological diseases, and Crohn's disease.
The
importance of curcumin can be estimated by the fact that thirty-seven
cases of
clinical trials of curcumin were completed by December
2017
and two cases FDA (Food and Drug administration) clinical phase 4
trials were
completed. Evaluation of the effect of curcumin on pneumonia: A
systematic
review of preclinical studies Phytotherapy Research | November
2020
Curcumin is a natural phytochemical with antiâ€inflammatory and
antiâ€neoplastic characteristics. Our results demonstrated that
curcumin
ameliorated the pneumoniaâ€induced lung injury, mainly through a
reduction of
the activity and infiltration of neutrophils and the inhibition of
inflammatory
response in mouse models. Curcumin ameliorates the severity of
pneumonia
through a reduction in neutrophil infiltration and by amelioration of
the
exaggerated immune response in preclinical pneumonia models. Effects of
the Use
of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic
Review
Journal of Medicinal Food | November
2020
The results of the randomized clinical trials (RCTs) showed promising
results
with the use of curcumin in the therapeutic approach of both UC and CD
patients. Some meta-analyses show controversial results, possibly due
to the
presence of bias in the included studies. The actions of curcumin are
achieved
by several mechanisms, such as reducing the expression of interleukin
(IL)-1,
IL-6, IL-12, and tumor necrosis factor-α. Moreover, it reduces the
levels of
reactive oxygen species, such as superoxide anions and malondialdehyde.
Evaluation of Cognitive Performance following Curcumin Supplementation
in
Middle-Aged and Older Adults with Overweight or Obesity The Journal of
Nutrition | November
2020
Curcumin improved CVR in a working memory test and, in males only,
performance
of a verbal memory test compared with placebo. Chemotherapeutic
efficacy of
curcumin and resveratrol against cancer: Chemoprevention,
chemoprotection, drug
synergism and clinical pharmacokinetics Seminars in Cancer Biology |
November
2020
Curcumin and resveratrol modulate the apoptosis and autophagy mediated
cell
death pathway for chemoprevention. Curcumin and resveratrol reduce
cytotoxicity
and exhibit chemo-protection during chemotherapy. Drug synergism and
advanced
drug delivery systems of curcumin and resveratrol enhances the
anticancer
efficacy. Enhanced pharmacokinetics and pharmacodynamics are
responsible for
better pre-clinical and clinical application. COVIDâ€19: A Case for
Inhibiting
NLRP3 Inflammasome, Suppression of Inflammation with Curcumin? Nordic
Pharmacological Society | November
2020
Curcumin is the effective ingredient of turmeric, sometimes used as a
painkiller in traditional medicine. Curcumin regulates several
molecules in the
intracellular signal transduction pathways involved in inflammation,
including
IBB, NFâ€kBERK1,2, APâ€1, TGFâ€Î², TXNIP, STAT3, PPARγ,
JAK2â€STAT3,
NLRP3, p38MAPK, Nrf2, Notchâ€1, AMPK, TLRâ€4 and MyDâ€88. Due to
antiâ€inflammatory and antiâ€inflammasome properties without any
special side
effects, curcumin can potentially play a role in the treatment of
COVIDâ€19
infection along with other drug regimens. Curcumin Suppresses
Tumorigenesis via
Promoting SLC1A5-mediated Ferroptosis in Breast Cancer Surgical
Oncology |
November
2020
Curcumin treatment significantly suppressed breast cancer cell
viability in a
dose-dependent manner. Moreover, curcumin triggered ferroptosis by
enhancing
the levels of lipid ROS, lipid peroxidation end-product MDA
accumulation, and
intracellular Fe2+. Mechanistically, curcumin administration impeded
tumor
growth via upregulating solute carrier family 1 member 5
(SLC1A5)-mediated
ferroptosis in breast cancer. In vivo experiments showed that curcumin
could
effectively hamper the growth of tumors without noticeable side
effects.
Conclusion: We demonstrated that curcumin exhibits anti-tumorigenesis
activity
in breast cancer by promoting SLC1A5-mediated ferroptosis, providing a
potential therapeutic agent for the treatment of breast cancer.
Curcumin
Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells
Technology in Cancer Research & Treatment | November
2020
Curcumin inhibited sE-cad expression and reversed EMT induced by
radiation.
Furthermore, curcumin suppressed sE-cad-enhanced A549 and A549R cell
migration
and invasion. Curcumin inhibited MMP9 expression, and silencing MMP9
suppressed
sE-cad expression. Taken together, we found a nonclassic EMT phenomenon
induced
by radiation. Curcumin inhibits NSCLC migration and invasion by
suppressing
radiation-induced EMT and sE-cad expression by decreasing MMP9
expression. Can
concomitant use of zinc and curcumin with other immunityâ€boosting
nutraceuticals be the arsenal against COVIDâ€19? Phytotherapy Research
|
November
2020
Curcumin is a natural bioactive polyphenolic compound isolated from the
dried
powder of Curcuma longa rhizomes, commonly known as turmeric (Haldi in
Hindi),
and widely used worldwide for cooking. Ayurveda mentioned the use of
turmeric
for numerous therapeutic purposes like blood coagulation to immune
stimulation.
An array of systemic antioxidant properties has been attributed to
curcuminâ€containing nutraceuticals. For example, it exerts an
antiâ€inflammatory action in arthritis and inflammatory bowel
diseases,
reduces lipid levels in cardiovascular diseases, and addresses
oxidative stress
in skin disorders. Curcumin has an established track record as an
antiviral
agent against several viruses like Influenza Type A, Hepatitis A, Zika,
HIV,
etc. The mode of action of curcumin includes—inhibition of viral
entry into
cells, suppression of viral replication, stimulation of interferons
(IFNs) and
other cytokines, and inhibition of viral protein expression. In silico
studies
have also revealed that curcumin binds directly with the
receptorâ€binding
domain of the viral spike protein (involved in host cell binding) and
the
cognate host cell receptor, angiotensinâ€converting enzymeâ€2 (serves
as a
medium of viral entry), of SARSâ€CoVâ€2 virus. Moreover, curcumin has
been
reported to inhibit the release and suppress numerous cytokines like
ILâ€1β,
ILâ€6, IL8, TNFα, MCPâ€1, etc. When investigated in various viral
infections
setâ€up, the mode of cytokine suppression by curcumin can be
correlated with
clinical improvement in conditions associated with cytokine storm.
Following
the suggested interaction with these key components of the viral
lifecycle and
immune system, it is apparent that curcumin could prevent the
COVIDâ€19
infection. Moreover, in recent years, blood coagulation properties of
curcumin
(by inhibiting platelet aggregation, cyclooxygenase pathway, and
blocking of
calcium signaling) have been utilized in designing various materials
and
devices. As the SARSâ€CoVâ€2 coronavirus infection can be associated
with a
disseminated intravascular coagulopathy, hence curcumin can be an
effective
agent against this pathological condition. Turmeric, Curcumin, and
Curcuminoids: A Dermatologic Review PracticalDermatology.com | November
2020
Research has shown that curcumin, one of the active compounds of
turmeric,
exhibits anti-inflammatory, antimicrobial, antioxidant,
anti-nociceptive, and
antineoplastic properties. Specifically, curcumin has been shown to
potentially
play a role in type 2 diabetes mellitus by reducing lipid levels, in
metabolic
syndrome by increasing insulin sensitivity and production, in cardiac
diseases
by lowering C reactive protein, and even in major depressive disorder
via its
anti-inflammatory effects. Currently, it is being studied as a possible
treatment for Alzheimer’s disease. Curcumin is thought to
downregulate
inflammatory targets, such as lipoxygenase, cycloxygenase-2, and
inducible
nitric oxide synthase. It has also been shown to inhibit many
inflammatory
cytokines, including TNF, IL-1, 2, 6, 8, and 12. Moreover, curcumin has
been
hypothesized to suppress NF-KB, which is a transcription factor that
controls
cycloxygenase-2 and inducible nitric oxide synthase and regulates
cellular
proliferation. These findings make curcumin a suitable candidate for
treating
skin conditions that are characterized by derangement of the
inflammatory
response. The potential therapeutic effects of curcumin on pregnancy
complications: Novel insights into reproductive medicine International
Union of
Biochemistry and Molecular Biology | November
2020
Curcumin, the main polyphenolic compound derived from Curcuma longa, is
mainly
known by its antiâ€inflammatory and antioxidant properties. There are
in vitro
and in vivo reports revealing the preventive and ameliorating effects
of
curcumin against pregnancy complications. Here, we aimed to seek
mechanisms
underlying the modulatory effects of curcumin on dysregulated
inflammatory and
oxidative responses in various pregnancy complications. Effect of
topical
curcumin on the healing of major oral mucosal ulceration Eurasian
Journal of
Biosciences | November
2020
Curcumin was a turmeric extract, its multifaceted biological effects
such as,
anti-inflammatory, anti-oxidant, anti-carcinogenic and anti-infectious
effects.
Results: The present study showed that the curcumin treatment reduce
mucosal
ulcer area from the 3rd day till 7th day and improved ulcer healing at
14th day
by activation of epithelial cell, inhibit inflammatory cells, enhance
endothelial cells and promote fibroblast cells. Effectiveness of
Curcuma longa
Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee
Osteoarthritis Annals of Internal Medicine | November
2020
Curcumin was more effective than placebo for knee pain but did not
affect knee
effusion–synovitis or cartilage composition. Therapeutic Effects of
Curcumin
Against Colorectal Cancer Phytochemicals Targeting Tumor in
Gastrointestinal
Cancer, October
2020
Curcumin is a product of the plant, Curcuma longa, which exhibits
anti-inflammatory, anti-infectious, and anticancer activities. A wide
variety
of evidences from numerous studies demonstrated that curcumin prevents
carcinogenesis, modulates signaling, inhibits angiogenesis and other
critical
aspects linked to cancer cell survival and proliferation, and induces
chemopreventive and anticancer activity against colorectal cancer.
Curcumin
also showed improved efficacy of chemotherapeutic agents in combination
studies. Antitumoral Effects of Curcumin (Curcuma longa L.) on
Neuroblastoma
Cell Lines Complementary Medicine Research, October
2020
Overall survival of high-risk neuroblastoma patients is still poor,
emphasizing
the need for novel therapeutic options. There is evidence for
anti-cancer
properties of the herbal substances thymoquinone and curcumin. Overall,
lower
IC50 values could be calculated for curcumin (3.75–7.42 µM) than for
thymoquinone (5.16–16.3 µM). Decreased proliferation and increased
apoptosis
rates were observed under treatment. Conclusions: Both substances
showed
anti-tumoral properties on neuroblastoma cell lines and should be
further
investigated as therapeutic agents. Curcumin reverses diabetic
nephropathy in
streptozotocin-induced diabetes The Journal of Nutritional
Biochemistry,
October
2020
Curcumin protects against T1DM-induced nephropathy. Mechanism of
protection
involves inhibition of oxidative stress, inflammation, and fibrosis.
Curcumin
seems to act by inhibiting PKC-induced activation of Psch66. Curcumin
an aid to
Cardiovascular diseases Financial Express, October
2020
Curcumin plays a very important role in protecting your heart from
these
cardiovascular diseases because the antioxidants in curcumin have been
shown to
attenuate adriamycin-induced cardiotoxicity and may prevent diabetic
cardiovascular complications. The anti-thrombotic, anti-proliferative,
and
anti-inflammatory effects of curcumin and the effect of curcumin in
decreasing
the serum cholesterol level may protect against the pathological
changes
occurring with atherosclerosis. Health Benefits Of Turmeric Maine News
Online,
October
2020
Turmeric is a readily available and natural remedy for chronic
inflammation. It
contains curcumin, which has excellent anti-inflammatory properties.
The
curcumin even makes turmeric more effective than most anti-inflammatory
drugs.
And besides, it is natural, accessible, pocket friendly, and has no
known side
effects. What curcumin does is to suppress the molecules responsible
for the
inflammation. By so doing, it will protect you from chronic
diseases.The
curcumin in turmeric, according to research, can lower oxidative
stress. It
serves as antioxidants and has the power to stimulate the body’s
antioxidant
enzymes. Consequently, this strengthens one’s immune system.What
makes
curcumin beneficial for your heart health is improving the endothelium
(blood
vessels’ lining) function. Curcumin’s anti-inflammatory and
antioxidant
functions also make it useful for maintaining your heart health.Studies
have
identified curcumin, which is present in turmeric, as a potent herb in
cancer
treatment. The studies also indicated that curcumin’s effect is the
same in
all cancer types. What curcumin does is that it fights cancer at the
molecular
level. It prevents the growth, spread, and development of the disease
in the
body. According to a study conducted by the MD Anderson Cancer Center,
researchers discovered that curcumin inhibits melanoma cells’ growth
and even
cause tumor cells to eliminate themselves. Curcumin can increase BDNF
levels in
the brain. With this action, it can encourage the reversal or delay of
brain-related decline or diseases. Studies have been conducted to
confirm
curcumin’s potency in arthritis treatment, and the outcome showed
great
promise. In one of the studies, curcumin proved to be more potent than
most
anti-inflammatory medication used in treating rheumatoid arthritis. As
documented in another study, curcumin’s use led to improvements in
various
symptoms most arthritis patients had. Turmeric’s effect on mental
health has
been well-documented. One of its constituents, curcumin, proves useful
in the
fight against depression. In one study involving 60 participants who
had
depression, the participants were divided into three groups. The first
group
was given an antidepressant; the second group had a gram of curcumin,
while the
third had both the antidepressant and curcumin. After six weeks,
curcumin’s
effect was similar to the antidepressant. Turmeric’s curcumin has
shown
promising antiviral properties. It can take down specific viruses, as
reported
by the Microbiology Society. In a study conducted, curcumin prevented
TGEV
(Transmissible gastroenteritis virus) from infecting cells. In high
dosage,
curcumin was able to eliminate the virus particles. Effect of Curcumin
on
Testis in Mice with Ehrlich Ascites Tumor New Trends in Medicine
Sciences,
October
2020
Findings clearly suggested that antioxidant parameters (except CAT and
GPx) had
higher value in animal models treated with 25 and 50 mg curcumin groups
associated to tumor control group. There was a statistically noteworthy
variance between the groups in all parameters. Antitumor effect of
curcumin on
ascites tumor cells produced by EAT cells evidenced with
histopathological
while antioxidant and anti-inflammatory biochemical parameters
evidenced with
biochemical parameters. An Exploratory Analysis of Changes in Mental
Wellbeing
Following Curcumin Supplementation in Middle-Aged and Older Adults
Nutrients,
October
2020
Curcumin has previously been shown to enhance mood in non-depressed
older
adults. In a 16 week randomized, double-blind, placebo-controlled, 2 ×
2
factorial design trial, we supplemented overweight or obese
non-depressed
adults (50–80 years) with curcumin (160 mg/day), fish oil (2000 mg
docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a
combination of
both. Curcumin improved vigour (p = 0.044) compared to placebo and
reduced SMCs
compared to no curcumin treatment (p = 0.038). This exploratory
analysis
indicates that regular supplementation with either curcumin (or fish
oil
limited to APOE4 non-carriers) has the potential to improve some
aspects of
mental wellbeing in association with better quality of life. Curcumin
administration and the effects on psychological status and markers of
inflammation and oxidative damage in patients with type 2 diabetes and
coronary
heart disease Clinical Nutrition and Metabolism, October
2020
Curcumin intake significantly decreased Pittsburgh Sleep Quality Index
(PSQI)
(β -1.27; 95% CI, -2.27, -0.31; P=0.01) compared to the placebo group.
Curcumin intake caused a significant reduction in malondialdehyde (MDA)
(β
-0.20 μmol/L; 95% CI, -0.36, -0.04; P=0.01), significant increase in
total
antioxidant capacity (TAC) (β 75.82 mmol/L; 95% CI, 3.400, 148.25;
P=0.04) and
glutathione (GSH) levels (β 63.48 μmol/L; 95% CI, 26.58, 100.37;
P=0.001)
when compared with the placebo. Additionally, curcumin intake
upregulated
peroxisome proliferator-activated receptor gamma (PPAR-γ) (P=0.01).
Conclusion: Curcumin intake for 12 weeks in patients with T2DM and CHD
had
beneficial effects on PSQI, TAC, GSH, MDA values, and gene expression
of
PPAR-γ. Interaction between Gut Microbiota and Curcumin: A New Key of
Understanding for the Health Effects of Curcumin Nutrients, October
2020
Curcumin, one of the major curcuminoids contained in the rhizome of
Curcuma
longa (turmeric), is a lipophilic polyphenol that has been used for
centuries
as an essential tool of traditional medicine in Asia. Curcumin has
received
considerable attention in the last years for its pharmacological
activities.
Due to the presence of conjugated double bonds in its chemical
structure, this
polyphenol serves as an effective electron donor to counteract the
production
of reactive oxygen species (ROS) in many redox reactions, acting as a
potent
antioxidant. In addition, it has other important biological functions,
such as
anti-inflammatory, antitumor, antimicrobial, and antiviral ones.
Different
studies highlighted that curcumin, like other dietary polyphenols,
counteracts
the effects of toxic damage in different tissues and, in addition, it
is able
to interfere with key cancer-associated signaling pathways by directly
targeting proteins or regulating gene expression. According to its
biological
activities, curcumin has been proposed as a potential treatment for
many
diseases, among which are gastrointestinal, cardiovascular, and
neurological
disorders, diabetes, and several types of cancer . Curcumin, a
lipophilic
polyphenol contained in the rhizome of Curcuma longa (turmeric), has
been used
for centuries in traditional Asian medicine, and nowadays it is widely
used in
food as dietary spice worldwide. It has received considerable attention
for its
pharmacological activities, which appear to act primarily through
anti-inflammatory and antioxidant mechanisms. For this reason, it has
been
proposed as a tool for the management of many diseases, among which are
gastrointestinal and neurological diseases, diabetes, and several types
of
cancer. The observed high concentrations of curcumin in the GI tract
after oral
administration can lead to two major effects: an altered gut microbiota
and the
modulation of intestinal functions. The scientific literatures were
searched
for in vivo, experimental and clinical studies, and human randomized
controlled
trials, reporting results on the interaction between curcumin and gut
microbiota and vice versa. Cardioprotective effect of curcumin against
diabetic
cardiomyopathy in type 1 diabetes mellitus Naunyn-Schmiedeberg's
Archives of
Pharmacology, October
2020
Treatment with curcumin markedly reduced serum cardiac injury markers
and lipid
profile markers in diabetic animals. Additionally, curcumin treatment
mitigated
oxidative stress and fibrosis in diabetic rats as evident from the
significant
suppression in myocardial lipid peroxidation and tumor growth factor
beta 1
(TGF-β1) level, with concomitant significant elevation in total
antioxidant
capacity (TAC) and improvement in histopathological architecture of
heart
tissue. Curcumin treatment protocol accomplished its cardioprotective
effect by
depressing cardiac CaMKII/NF-κB signaling accompanied by enhancement
in
PPAR-γ expression. Conclusively, these findings demonstrated the
therapeutic
potential of curcumin regimen in alleviating DCM in T1DM through
modulation of
CaMKII and PPAR-γ expression. Curcumin Allosterically Inhibits the
Dengue
NS2B-NS3 Protease by Disrupting Its Active Conformation ACS Omega,
October
2020
Flaviviruses including dengue virus and Zika virus encode a unique
two-component NS2B-NS3 protease essential for maturation/infectivity,
thus
representing a key target for designing antiflavivirus drugs. Here, for
the
first time, by NMR and molecular docking, we reveal that curcumin
allosterically inhibits the dengue protease by binding to a cavity with
no
overlap with the active site. Moreover, as curcumin has been used as a
food
additive for thousands of years in many counties, it can be directly
utilized
to fight the flaviviral infections and as a promising starting for
further
design of potent allosteric inhibitors. Fight COVID-19 depression with
immunity
booster: Curcumin for psychoneuroimmunomodulation Asian Journal of
Psychiatry,
September
2020
Curcumin is the bioactive component of turmeric, one of the key
ingredients of
prescribed ayurvedic interventions and spices used in meal preparation
in
South-East Asia. Known for immunoboosting aptitude, curcumin can
alleviate the
COVID-19 associated ill-effects including cytokine storm. Alleviating
psychological stress by curcumin will also adjunct its immunoboosting
potential. Curcumin can avert the anxiety and the stress-driven
manifestation
of depression through modulation of the monoaminergic troupe (dopamine,
glutamate, serotonin, and noradrenaline) by curcumin. Curcumin, through
Nuclear
factor erythroid-2-related factor 2 (Nrf2), can prevent such stress and
improve
antioxidant Glutathione (GSH) production. Major depression disorders
(MDD)
associate with disturbances in the hypothalamus-pituitary-adrenal (HPA)
axis.
Curcumin can correct the HPA disturbances and avert elevated
glucocorticoids,
their receptor as well as inducers (cortisone and adrenocorticotropic
hormone).
Along with evident immunomodulator, turmeric component, especially
curcumin
exhibit antidepressant activity, and improve cognitive/mood function.
The
potential of curcumin containing nutraceutical in COVID-19 has been
predicted
both through PNI modulation and 'meaning response'. Moreover, curcumin
can
alleviate the overt inflammatory consequences, even those associated
with
COVID-19, and thus will improve physical well-being. Curcumin
ameliorates
inflammation and its regulators like STAT3 in a variety of disorders
including
COVID-19. Curcumin can improve the hematopoietic differentiation of
immune
cells; and thus can mitigate ill effects even through reinstating
immune cells
number. Moreover, curcumin improves neurogenesis and hippocampus
functioning.
Curcumin-mediated immunoboosting, antidepressant effect, and
neurogenesis may
also improve the mood function and ward off anxiety/stress in a covert
manner.
Nutraceuticals like curcumin can be a promising option as immunity
boosters and
antidepressants for PNI response. Traditionally used in medicinal
practices,
clinical safety of turmeric (and curcumin) is well assessed. Moreover,
relative
low case fatality rates (CFR) of COVID-19 in South-Asian countries like
India
are being recorded which can be governed by several factors, including
diet and
traditional medicine practice. Although the novel nature of the
COVID-19
pandemic makes the efficacy of previously known drugs anonymous,
ascertaining
the true potential of curcumin through preclinical and clinical
investigations
will be of immense benefit. Immunoboosting as well as improvement of
psychological well-being by curcumin; thus can be hypothesized to
facilitate
improvement in infected patients, health care workers as well as
distantly
affected individuals. Pyschoneuroimmunomodulation by curcumin, even as
an
adjuvant, can aid the fight against COVID-19. Curcumin Regulates ERCC1
Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal
Cancer
Cells Evidence-Based Complementary and Alternative Medicine, September
2020
Previous studies have confirmed that curcumin displays antitumor
effects on a
variety of cancers, including colorectal tumors. In addition, curcumin
has been
shown to prevent tumor resistance. Mehdi et al. found that curcumin
combined
with 5-fluorouracil can improve the chemotherapeutic effects of 5FU on
colorectal cancer resistant strains by reducing mismatch repair
ability.
Curcumin can reverse the drug resistance of cancer cells. Curcumin was
found to
inhibit ERCC1 through its ability to modulate miR-409-3p. Curcumin can
overcome
L-OHP resistance in colorectal cancer cells through its effects on
miR-409-3p
mediated ERCC1 expression. Curcumin (a constituent of turmeric): New
treatment
option against COVIDâ€19 Food Science & Nutrition, September
2020
We describe the possible therapeutic effects of curcumin and its
molecular
mechanism against coronavirusâ€19. Curcumin, as an active constituent
of
Curcuma longa (turmeric), has been studied in several experimental and
clinical
trial studies. Curcumin has some useful clinical effects such as
antiviral,
antinociceptive, antiâ€inflammatory, antipyretic, and antifatigue
effects that
could be effective to manage the symptoms of the infected patient with
COVIDâ€19. Curcumin, as a potential agent, could be considered to
treat
COVIDâ€19. Curcumin, as an active constituent of rhizomes of C. longa
(turmeric), is a hydrophobic polyphenol (Figure 1) (Akbar et al.,
2018
; Soleimani, Sahebkar, & Hosseinzadeh,
2018
). Curcumin is used as a spice in foods and for different purposes such
as
cosmetic and pharmaceutical industries in world (Hosseini &
Hosseinzadeh,
2018
). Curcumin has several pharmacological effects such as antioxidant,
anticancer, antibacterial, antiviral, and antidiabetic effects (Fan et
al.,
2015
; Moghadamtousi et al.,
2014
; Zhu et al.,
2017
), as well as antiâ€inflammatory activity (Cheng, Yang, Hu, Zhu, &
Liu,
2018
). As the potential role of curcumin to treat many inflammatory
disorders, at
the first step we will describe all effects of curcumin that may be
useful to
treat COVIDâ€19, and then, we explain the possible molecular
mechanisms of it.
We considered all articles of curcumin—human and animal
studies—that could
be effective to treat or rescue COVIDâ€19â€infected patients. PubMed
and Web
of Science were used as databases. As the importance of the subject,
some
selected papers were in the press. The keywords used for the search
were as
follows: coronavirusâ€19, COVIDâ€19, SARSâ€CoVâ€2, curcumin,
Curcuma longa,
turmeric, curcumin and antiviral, curcumin and antiâ€inflammatory,
curcumin
and antipyretic, curcumin and lung, curcumin and acute lung injury,
curcumin
and fatigue, curcumin and antioxidant, curcumin and ARDS, curcumin and
bradykinin, curcumin and fibrosis, curcumin and Interleukinâ€6
(ILâ€6),
curcumin and tumor necrosis factorâ€alpha (TNFâ€Î±), curcumin and
NFâ€ÎºB,
curcumin and Tollâ€like receptors (TLRs), curcumin and antiapoptotic.
Scientific evidence suggests that curcumin could have a potential role
to treat
COVIDâ€19. Thus, the use of curcumin in the clinical trial, as a new
treatment
option, should be considered. Curcumin supplementation and delayed
onset muscle
soreness (DOMS): effects, mechanisms, and practical considerations
Physical
Activity and Nutrition, September Curcumin, also called
diferuloylmethane, is a
well-known spice used in curry in India and other Asian countries. It
is a
natural polyphenol that has attracted attention for its
anti-inflammatory,
antioxidant, and anticancer activities. Studies have found that
curcumin
significantly reduces pain from burns as well as pathological pain
caused by
sciatic nerve injury, spinal cord injury, diabetic neuropathy, and
alcoholic
neuropathy. Researchers in the field of exercise physiology have
investigated
the effect of curcumin on post-exercise DOMS, with a few studies
reporting that
curcumin supplementation can effectively attenuate DOMS after
high-intensity
eccentric exercise. Curcumin’s Suppressive Effects on
Epithelial-Mesenchymal
Transition in Colorectal Cancer Cells Medical Science Monitor,
September
2020
Curcumin is a component of Curcuma longa with various biological
activities.
The present study aimed to investigate curcumin’s inhibitory effects
on
epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC)
cells and
possible mechanisms of action underlying these effects. Curcumin
negatively
regulated transcription factors promoting EMT in CRC cells by
decreasing cdx2
promoter DNA methylation and consequently suppressing the
CDX2/Wnt3a/ß-catenin
signaling pathway. Potential role of Curcumin against viral infections
and
pathogenesis of COVID-19 Department of Bioanalytical Sciences,
September
2020
The review intended to provide link between natural product as
treatment and
COVID-19 disease. Therefore, this review summarizes the structure,
pathogenesis
as well as understanding the various role of curcumin as a treatment
option for
COVID-19 which includes: targeting viral entry to host cells, targeting
viral
replication, anti-viral, anti-inflammatory and anti-oxidant. Hence,
curcumin
can be a potential treatment option for COVID-19 patients and this
review also
suggest that more clinical research and development is needed in order
to
prepare a new drug for emerging SARS-CoV-2. Curcumin as an Antiviral
Agent-Inhibition of Viral attachment/penetration. The antiviral
activities of
curcumin were observed from many evidences against vesicular stomatitis
virus,
parainfluenza virus type 3, vesicular stomatitis virus, flock house
virus,
herpes simplex virus, and respiratory syncytial virus. Curcumin can
block the
entry and budding of the virus by altering the structure of the surface
protein
in viruses. Recently, a molecular docking analysis through in silico
computational study Jena et al. revealed that curcumin have dual
binding
affinity directly with the S protein and ACE-2 receptor binding domain
of the
SARS-CoV-2 virus. ACE-2 is the receptor that binds with SARS-CoV-2
spike
glycoprotein which promote the fusion ofmembrane and viral infection
occurs
through endocytosis. Therefore, spike glycoprotein is a potential
candidate for
drug targeting to inhibit the entry of virus.Binding of curcumin to
receptor-binding domain (RBD) site of viral S protein and also to the
viral
attachment sites of ACE-2 receptor, revealed that curcumin can act as
potential
inhibitory agent for the entry of SARS-CoV2 viral protein. This in
silico
docking studies showedthat curcumin may effectively prevent the
SARS-CoV2 entry
into the host cell. Many in vivo and in vitro studies showed that
curcumin can
inhibit the production and release of pro-inflammatory response, such
as IL-1,
IL-6, IL-8, TNF-α. Curcumin also decreases expression of many other
inflammatory mediators, including MCP1,MIPI1, growth regulated oncogene
alpha
(GROα), GROβ, IP10, stromal cell derived factor 1 (SDF1), matrix
metalloproteinase-2 (MMP-2), IFN-γ, and MMP-9, which regulate the
activity of
immune cells and inflammatory responses and promote fibrosis in the
lung after
infection. Anti-inflammatory activity of curcumin involves various
signalling
pathways, from which nuclear factor kappa B (NF-kB)plays a vital role
in
managing numerous inflammatory responses through multiple mechanisms.
Does
Curcumin Have a Role in the Interaction between Gut Microbiota and
Schistosoma
mansoni in Mice? Pathogens, September
2020
Several studies have described therapeutic effects of curcumin which
may arise
from its regulative effects on intestinal microbiota. Curcumin induced
high
variation in the Enterobacteriaceae family, characterized by a
significant
reduction in E. coli and asignificant increase in Pseudomonas sp. in
both
naïve and S. mansoni-infected mice, compared to untreated mice, in a
dose-dependent manner. Additionally, our study showed the effects of
high
curcumin doses on S. mansoni infection immunological and
parasitological
parameters. These data support curcumin’s ability to promote
Pseudomonas sp.
known to produce schistosomicidal toxins and offset the sequelae of
murine
schistosomiasis. Effect of concomitant treatment of curcumin and
melatonin on
cisplatin-induced nephrotoxicity in rats Biomedicine &
Pharmacotherapy,
September
2020
Curcumin showed a protective effect against cisplatin-induced
nephrotoxicity.
Combination of curcumin and melatonin showed an additive
nephroprotective
effect. Nephroprotection is attributed to their anti-inflammatory and
antioxidant actions. Curcumin Suppresses Aldosterone-Induced CRP
Generation
Evidence-Based Complementary and Alternative Medicine, September
2020
Curcumin is the most active ingredient of turmeric with
anti-inflammation and
antioxidation effects. Here, the effect of curcumin on
aldosterone-induced
C-reactive protein generation in vascular smooth muscle and the
molecular
mechanisms involved were explored. We found that curcumin inhibited
aldosterone-induced C-reactive protein generation in vascular smooth
muscle
cells by interfering with the reactive oxygen species-ERK1/2 signal
pathway.
The results provide new evidence for the potential anti-inflammatory
and
cardiovascular protective effects of curcumin. Curcumin: a Wonder Drug
as a
Preventive Measure for COVID19 Management Indian Journal of Clinical
Biochemistry, September
2020
Curcumin is one of the natural compounds that had been widely
investigated for
its antiviral effects. Curcumin, a natural polyphenolic compound
extracted from
roots of rhizome plant Curcuma longa (family Zingiberaceae), exhibits
wide
range of therapeutic properties including antioxidant, anti-microbial,
anti-proliferative, anti-inflammatory, neuroprotective and
cardioprotective
properties. Curcumin, the yellow pigment of turmeric is extensively
used in our
Indian traditional herbal medicines to cure many diseases associated
with
infection and inflammation for many decades. It is reported that,
curcumin
exerts antiviral activities against broad spectrum of viruses including
HIV,
HSV-2, HPV viruses, Influenza virus, Zikavirus, Hepatitis virus and
Adenovirus.
In conclusion, we propose that curcumin could be used as a supportive
therapy
in the treatment of COVID19 disease in any clinical settings to
circumvent the
lethal effects of SARS-CoV-2. Can concomitant use of zinc and curcumin
with
other immunityâ€boosting nutraceuticals be the arsenal against
COVIDâ€19? The
Pharmacological Potential of Plant Compounds in COVID-19, September
2020
We can expand our discussion by taking the example of two nutritional
supplements—Curcuminoids and Zn—which have been classified under
GRAS, by
FDA, as nutraceutical and nutrient. Both molecules have a proven
history of
antiviral activity in both in vitro and in vivo trials, and thus could
be
leading in developing new prophylactic candidates against COVIDâ€19.
Curcumin
is a natural bioactive polyphenolic compound isolated from the dried
powder of
Curcuma longa rhizomes, commonly known as turmeric (Haldi in Hindi),
and widely
used worldwide for cooking. For example, it exerts an
antiâ€inflammatory
action in arthritis and inflammatory bowel diseases, reduces lipid
levels in
cardiovascular diseases, and addresses oxidative stress in skin
disorders
(Pagano, Romano, Izzo, & Borrelli,
2018
). Curcumin has an established track record as an antiviral agent
against
several viruses like Influenza Type A, Hepatitis A, Zika, HIV, etc. The
mode of
action of curcumin includes—inhibition of viral entry into cells,
suppression
of viral replication, stimulation of interferons (IFNs) and other
cytokines,
and inhibition of viral protein expression. In silico studies have also
revealed that curcumin binds directly with the receptorâ€binding
domain of the
viral spike protein (involved in host cell binding) and the cognate
host cell
receptor, angiotensinâ€converting enzymeâ€2 (serves as a medium of
viral
entry), of SARSâ€CoVâ€2 virus (Figure 1). Moreover, curcumin has been
reported to inhibit the release and suppress numerous cytokines like
ILâ€1β,
ILâ€6, IL8, TNFα, MCPâ€1, etc. When investigated in various viral
infections
setâ€up, the mode of cytokine suppression by curcumin can be
correlated with
clinical improvement in conditions associated with cytokine storm
(Sordillo &
Helson,
2015
). Following the suggested interaction with these key components of the
viral
lifecycle and immune system, it is apparent that curcumin could prevent
the
COVIDâ€19 infection. Moreover, in recent years, blood coagulation
properties
of curcumin (by inhibiting platelet aggregation, cyclooxygenase
pathway, and
blocking of calcium signaling) have been utilized in designing various
materials and devices (Keihanian, Saeidinia, Bagheri, Johnston, &
Sahebkar,
2018
). As the SARSâ€CoVâ€2 coronavirus infection can be associated with a
disseminated intravascular coagulopathy, hence curcumin can be an
effective
agent against this pathological condition. The Inhibitory Effect of
Curcumin on
Virus-Induced Cytokine Storm and Its Potential Use in the Associated
Severe
Pneumonia Frontiers in Cell and Developmental Biology, September
2020
Coronavirus infection, including SARS-CoV, MERS-CoV, and SARS-CoV2,
causes
daunting diseases that can be fatal because of lung failure and
systemic
cytokine storm. No drugs are available to suppress overly immune
response-mediated lung injury effectively. In light of the low toxicity
and its
antioxidant, anti-inflammatory, and antiviral activity, it is plausible
to
speculate that curcumin could be used as a therapeutic drug for viral
pneumonia
and ALI/ARDS. Therefore, in this review, we summarize the mounting
evidence
obtained from preclinical studies using animal models of lethal
pneumonia where
curcumin exerts protective effects by regulating the expression of both
pro-
and anti-inflammatory factors such as IL-6, IL-8, IL-10, and COX-2,
promoting
the apoptosis of PMN cells, and scavenging the reactive oxygen species
(ROS),
which exacerbates the inflammatory response. These studies provide a
rationale
that curcumin can be used as a therapeutic agent against pneumonia and
ALI/ARDS
in humans resulting from coronaviral infection. Catechin and Curcumin
interact
with corona
(2019
-nCoV/SARS-CoV2) viral S protein and ACE2 of human cell membrane
Pharmacodynamics, September
2020
The recent outbreak of the coronavirus
(2019
n-CoV) is an unprecedented threat for human health throughout the
globe. Here,
through computational approaches we have reported two polyphenols,
Catechin and
Curcumin which have dual binding affinity i.e both the molecule binds
to viral
S-protein and as well as ACE2. Molecular simulation study demonstrates
that
curcumin directly binds with RBD site of S-protein during 40-100ns. In
conclusion, this computational study for the first time predicts the
possibility of above two polyphenols, for therapeutic/preventive
intervention.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors:
curcuminoids against novel SARS-CoV-2 Royal Society of Chemistry,
August
2020
We focused on the natural plant Curcuma longa, commonly known as
turmeric, a
perennial herbaceous rhizomatous plant belonging to the ginger family
Zingiberaceae, which is widely used in India.Curcuma longa chemical
constitutes
are widely used for treating various ailments and possess a wide
variety of
therapeutic properties including
antiviral,analgesic,antimicrobial,antiproliferative,and
anti-inflammatory
activity. Among the various chemical compounds, curcumin has gained
importance
among researchers because its compounds have been exhibited activity
against
viruses such as the human immunodeficiency virus (HIV), dengue virus,
herpes
simplex virus (HSV), hepatitis virus, influenza A virus (IAV), and
Ebola
virus.SARS-CoV-2 has resulted in a devastating pandemic with global
concern;
however, present therapies in virology fail to prevent its effects.
Currently,
there is exigency in identifying novel leads with anti-viral properties
to
impede viral pathogenesis in the host system. Thus, two important
curcuminoids
of turmeric, i.e., its curcumin keto and enol forms, were demonstrated
to be
complementary to bind with the S-glycoprotein and envelope protein of
SARS-CoV-2. However, the keto form of curcumin is more favourable for
both
these drug targets considering its docking score, binding energy and
molecular
dynamics simulation. Thus, this study indicates that surface proteins
are key
drug target proteins of SARS-CoV-2, and probably curcumin blocks
essential
biologically active drug target residues, thereby attenuating the viral
infection. Hence, this computational biology approach identifies
curcumin as a
drug candidate for further investigation in treating SARS-CoV-2.
Antiviral and
virucidal effects of curcumin Journal of General Virology, August
2020
Emerging coronaviruses represent serious threats to human and animal
health
worldwide, and no approved therapeutics are currently available. Here,
we used
Transmissible gastroenteritis virus (TGEV) as the alpha-coronavirus
model, and
investigated the antiviral properties of curcumin against TGEV. Our
results
demonstrated that curcumin strongly inhibited TGEV proliferation and
viral
protein expression in a dose-dependent manner. We also observed that
curcumin
exhibited direct virucidal abilities in a dose-, temperature- and
time-dependent manner. Furthermore, time-of-addition assays showed that
curcumin mainly acted in the early phase of TGEV replication. Notably,
in an
adsorption assay, curcumin at 40 µM resulted in a reduction in viral
titres
of 3.55 log TCID50 ml–1, indicating that curcumin possesses excellent
inhibitory effects on the adsorption of TGEV. Collectively, we
demonstrate for
the first time that curcumin has virucidal activity and virtual
inhibition
against TGEV, suggesting that curcumin might be a candidate drug for
effective
control of TGEV infection. Turmeric could have antiviral properties
Microbiology Society, August
2020
Curcumin, a natural compound found in the spice turmeric, could help
eliminate
certain viruses, research has found. A study published in the Journal
of
General Virology showed that curcumin can prevent Transmissible
gastroenteritis
virus (TGEV) – an alpha-group coronavirus that infects pigs – from
infecting cells. At higher doses, the compound was also found to kill
virus
particles. The research suggests that curcumin affects TGEV in a number
of
ways: by directly killing the virus before it is able to infect the
cell, by
integrating with the viral envelope to ‘inactivate’ the virus, and
by
altering the metabolism of cells to prevent viral entry. “Curcumin
has a
significant inhibitory effect on TGEV adsorption step and a certain
direct
inactivation effect, suggesting that curcumin has great potential in
the
prevention of TGEV infection,†said Dr Lilan Xie, lead author of the
study
and researcher at the Wuhan Institute of Bioengineering. Curcumin has
been
shown to inhibit the replication of some types of virus, including
dengue
virus, hepatitis B and Zika virus. The compound has also been found to
have a
number of significant biological effects, including antitumor,
anti-inflammatory and antibacterial activities. Curcumin was chosen for
this
research due to having low side effects according to Dr Xie. Turmeric
may have
antiviral properties labonline, August
2020
To determine the potential antiviral properties of curcumin, scientists
from
the Wuhan Institute of Bioengineering treated experimental cells with
various
concentrations of the compound, before attempting to infect them with
TGEV.
They found that higher concentrations of curcumin reduced the number of
virus
particles in the cell culture. Curcumin enhances anti‑cancer efficacy
on
pancreatic cancer cells Oncology Reports, August
2020
Curcumin is a natural compound extracted from turmeric (Curcuma longa),
which
has been reported to be a promising anti‑cancer drug in various human
cancers. Curcumin exhibited marked suppressive ability on metastasis of
PC
cells by wound healing and matrigel‑transwell assay. Mechanistically,
upregulation of TIMP1/TIMP2 with concomitant downregulation of
MMP2/MMP9/N‑cadherin proteins may be involved in this process. In
conclusion,
curcumin showed synergistic anti‑cancer effects with either
gemcitabine or
docetaxel on PC cells. Accelerated Muscle Recovery After In Vivo
Curcumin
Supplementation Graduate Institute of Metabolism and Obesity Sciences,
August
2020
For the contusion-induced muscle injury, curcumin could affect the
specific
proteins of inflammation, neutrophils, and differentiation of satellite
cells,
including Ikk-α/ß, MPO, and myogenin. In conclusion, curcumin
potentially
accelerates muscle recovery; therefore, it may be a potential candidate
for
further research as an effective treatment to enhance muscle repair.
Curcumin
Protects Against Radiotherapy-Induced Oxidative Injury to the Skin Drug
Design,
Development and Therapy, August
2020
The administration of curcumin before and after irradiation prevented
radiotherapy-induced oxidative damage by significantly elevating the
activities
of antioxidant enzymes. From the findings of the present study,
curcumin showed
potential for protection against radiotherapy induced oxidative injury
to the
skin. However, future studies are required to evaluate its clinical
efficacy.
The Spice That Protects Your Brain TheEpochTimes, August
2020
Previous research on curcumin indicates that it is capable of acting as
an
antioxidant in three distinct ways by protecting against 1) singlet
oxygen, 2)
hydroxyl radicals, and 3) superoxide radical damage. Also, curcumin
appears to
raise endogenous glutathione production in the brain, a major
antioxidant
defense system. Supplementation with curcumin significantly reduced the
toxic
effect of fluoride to near normal level by augmenting the antioxidant
defense
through its scavenging property and provides evidence of having a
therapeutic
role against oxidative stress mediated neurodegeneration.†This is
far from
the first study to demonstrate curcumin’s remarkable brain-saving
properties.
From the perspective of the primary research alone, there are more than
200
peer-reviewed published studies indicating that curcumin is a
neuroprotective
agent. On GreenMedInfo’s turmeric database there are 115 articles
proving
turmeric protects the brain. There are also two featured studies on
turmeric’s ability to protect and restore the brain: How Turmeric Can
Save
the Aging Brain From Dementia and Premature Death, and Turmeric
Produces
‘Remarkable’ Recovery in Alzheimer’s Patients. Considering the
many
chemical insults we face on a daily basis in the post-industrial world,
turmeric may very well be the world’s most important herb, with more
than 800
evidence-based health applications. Effects of curcumin, D-pinitol
alone or in
combination in cytotoxicity induced by arsenic Food and Chemical
Toxicology,
August
2020
Curcumin decreases cell viability of PC12 cells unlike D-pinitol.
Arsenic
induced cell death via both mitochondria-mediated intrinsic apoptosis
and
autophagy. Curcumin and D-pinitol alone or in combination efficiently
protects
PC12 cells from arsenic-induced cytotoxicity. The combined
cytoprotection of
curcumin and D-pinitol against arsenic-toxicity was higher than their
individual protection. Magical benefits of herbs Northampton Chronicle,
August
2020
Curcumin is undergoing many studies to investigate its
anti-inflammatory
properties. Already shown to be able to slow down inflammation, there
are
clinical trials being performed comparing this compound with
anti-inflammatory
drugs, like Ibuprofen. Curcumin has also been linked to helping
pre-menstrual
tension, acne, arthritis, depression. Clinical studies are also under
way to
investigate its function with Alzheimer’s Disease and some cancers.
Potential
Effects of Curcumin in the Treatment of COVID-19 Infection Phytotherapy
Research, July
2020
Coronavirus disease (COVID-19) outbreak is an ongoing pandemic caused
by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable
mortality worldwide. The main clinical manifestation of COVID-19 is the
presence of respiratory symptoms, but some patients develop severe
cardiovascular and renal complications. There is an urgency to
understand the
mechanism by which this virus causes complications so as to develop
treatment
options. Curcumin, a natural polyphenolic compound, could be a
potential
treatment option for patients with coronavirus disease. In this study,
we
review some of the potential effects of curcumin such as inhibiting the
entry
of virus to the cell, inhibiting encapsulation of the virus and viral
protease,
as well as modulating various cellular signaling pathways. This review
provides
a basis for further research and development of clinical applications
of
curcumin for the treatment of newly emerged SARS-CoV-2. Antiviral
benefits of
curcumin nutritionaloutlook, July
2020
A new review explores the potential effects of curcumin on COVID-19
infection.
Based on existing data from in silico and animal studies on curcumin
and viral
infection, the review serves as a groundwork for future study of
curcumin as a
possible treatment. The review cites studies that point to curcumin’s
ability
to potentially inhibit the entry of virus to the cell, inhibit
encapsulation of
the virus and viral protease, as well as modulate various cellular
signaling
pathways. The review also cites studies in which curcumin was effective
in
pulmonary inflammation, fibrosis, and edema, as well as the
recuperative
actions of curcumin on cardiac and kidney damage caused by viral
infections.
Curcumin - Properties, Applications and Modification of Structure
eurekaselect,
July
2020
In recent years, the interest in biologically active compounds of
natural
origin has increased significantly. Researchers' research focuses on
increasing
the activity of curcumin by forming complexes with metals such as
vanadium,
iron, copper or gallium. Introduction of metal compounds to curcumin
increases
the scope of application in pharmacology. The main direction of
research
development is the treatment of tumors, among others stomach cancer or
leukemia. Curcuminoids are the main components of turmeric (Curcuma
longa L.),
a plant from India and South-East Asia. Due to its intense
yellow-orange color
and pleasant aroma, the powdered rootstalk is widely used in the food
industry,
as natural dye and spice. The chemical compound responsible for the
characteristic color of rhizomes of curcuma is
1,6-heptadien-3,5-dione-1,7-bis(4-hydroxy-3-methoxyphenyl) - (1E, 6E)
called
curcumin. This work aims to characterize curcumin in terms of its
structure,
therapeutic properties and also as a substrate for the synthesis of
valuable
derivatives like tetrahydrocurcumin. Knowledge about this relationship
based on
literature analysis will enable a better understanding of the factors
responsible for its biological activity. Turmeric: The Spice for Life
ttownmedia, July
2020
For centuries it has been known that turmeric exhibits
anti-inflammatory
activity, but extensive research performed within the past two decades
has
shown that this activity of turmeric is due to curcumin. The process of
inflammation has been shown to play a role in most chronic illnesses,
including
neurodegenerative, cardiovascular and autoimmune. In this study
published in
the Jan.
2009
issue of the " International Journal of Biochemistry & Cell
Biology"
researchers provided evidence for the potential role of curcumin in the
prevention and treatment of various proinflammatory chronic diseases.
Because
curcumin can help keep blood sugar levels steady, it could be effective
as a
way of preventing or treating type 2 diabetes. One study, as reported
in an
article on turmeric in WEB MD, followed 240 adults with prediabetes and
found
that taking a curcumin supplement over 9 months lowered their odds of
developing diabetes. Additionally, curcumin has shown promise for its
ability
to ease joint pain, stiffness, abdominal pain, headaches and migraines.
There
is evidence to suggest the curcumin may help in weight loss. Studies
find that
curcumin may regulate lipid metabolism, which plays a central role in
the
development of obesity and its complications. ` Research published in
the
journal "Pharmaceutical Research" Jan
2017
discusses the evidence of curcumin's effectiveness on pulmonary
diseases such
as asthma, COPD, pulmonary fibrosis and lung cancer. According to Dr.
Goel,
Ph.D., director of Cancer Prevention at Baylor University Medical
Center and
curcumin researcher: "Curcumin demonstrates superior antioxidant and
anti-inflammatory effects and provides liver- and heart-protective
benefits as
well. It is a potent antibacterial, antifungal, antiviral,
anti-allergenic and
has antitumor and anti-cancer properties." A Randomized Controlled
Trial
reported in the Aug.
2009
issue of "The Journal of Alternative and Complementary Medicine"
conclude that
curcumin was as safe and effective for treating knee osteoarthritis as
ibuprofen. A
2016
Meta-Analysis of over 28 studies concluded that scientific evidence
supported
the efficacy of turmeric extract (about 1000 mg/day of curcumin) in the
treatment of arthritis. Curcumin-enhanced antitumor effects Food &
Function,
July
2020
Curcumin, the main active ingredient of turmeric, is widely used as a
kind of
food additive and also displays a range of pharmacological activities,
such as
anti-inflammation, anti-tumor, liver and kidney protection, and so
forth. It
was found that curcumin protected against liver cancer progression
through
reducing the level of alpha fetoprotein in liver tissues, increasing
the number
of immune cells, like NK cells, inhibiting EMT via the regulation of
IL-6/JAK/STAT3 and IL-1β/NF-κB pathways, suppressing anaerobic
glycolysis
through the inhibition of LDH and HIF-1α, and decreasing the lipid
synthesis
via the downregulation of FASN, and upregulated the serum HDL-C and
mRNA levels
of apoA1 in the sorafenib-treated mice. Furthermore, curcumin
regulation of the
disorder of glycolipid metabolism and EMT was also based on the
PI3K/AKT
pathway. A docking study was performed and proved the strong affinity
between
curcumin and the proteins of STAT3, FASN, and AKT. All in all, this
experiment
provided evidence for the addition of curcumin in the diet to enhance
the
antitumor efficacy of sorafenib through activating immune function,
downregulating EMT, and reversing disorders of the metabolism. Support
Your
Immune System marieclaire, July
2020
Turmeric rates as a high immunity-boosting food due to the levels of
curcumin
that are found in it. Curcumin can enhance the antibody response by
activating
the T cells, B cells, neutrophils (white blood cells that heal damaged
tissues
and resolve infections) and Natural Killer cells, all of which help
your body
to fight off infection. Curcumin is also a fantastic anti-inflammatory,
which
helps your immune system by reducing the amount of inflammation within
your
body. The more inflammation you have, the less able your body is able
to fight
off any potential microbes. Curcumin exerts protective effect on PC12
cells
europeanreview, July
2020
Our study indicates that curcumin exerts protective effect against
lidocaine-induced cytotoxicity on PC12 cells by suppressing the
activity of
NLRP3 inflammasome, which provides new ideas on screening natural
product for
neurological damage therapy. Curcumin protects BV2 Molecular Biology
Reports,
July
2020
Curcumin was demonstrated to be an active ingredient with
anti-inflammatory
effects. This research was to investigate the effects of curcumin. We
found
that curcumin promoted cell viability and suppressed cell apoptosis.
Meanwhile,
curcumin decreased the level of cleaved caspase-3 and the release of
TNF-α,
IL-1β, IL-6, but increased IL-10 release in LPS-treated BV2 cells.
Furthermore, curcumin suppressed p-p65 expression via regulating
miR-362-3p/TLR4 axis. We discovered that curcumin exhibited protective
effects
against LPS-triggered cell injury via modulating miR-362-3p/TLR4 axis
through
NF-κB pathway. Improving Lung Function ndtv, July
2020
Curcumin in turmeric has antioxidant and anti-inflammatory effects
which can be
beneficial for supporting lung function. Curcumin-Induced DNA
Demethylation in
Human Gastric Cancer Cells Oxidative Medicine and Cellular Longevity,
July
2020
Curcumin, a natural polyphenol antioxidant extracted from the root of
turmeric
(Curcuma longa), can induce apoptosis and DNA demethylation in several
types of
cancer cells. We observed that curcumin inhibited the proliferation,
colony
formation, and migration of hGCCs in a dose- and time-dependent
fashion. A high
concentration of curcumin elevated ROS levels and triggered
mitochondrial
damage, DNA damage, and apoptosis of hGCCs. Further, curcumin-induced
DNA
demethylation of hGCCs was mediated by the damaged DNA
repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis. We propose that
the
anticancer effect of curcumin could largely be attributed to its
prooxidative
effect at high concentrations and ROS elevation in cancer cells.
Moreover, we
present a novel mechanism by which curcumin induces DNA demethylation
of hGCCs,
suggesting the need to further investigate the demethylation mechanisms
of
other DNA hypomethylating drugs. Type 2 diabetes: A spice proven to
help lower
blood sugar and help with treatment express.co.uk In a study with the
US
National Library of Medicine National Institutes of Health, curcumin
and how it
affects diabetes was investigated. The study noted: “The active
component of
turmeric, curcumin, has caught attention as a potential treatment for
diabetes
and its complications primarily because it is a relatively safe and
inexpensive
drug that reduces glycemia and hyperlipidaemia in rodent models of
diabetes.
“The spice turmeric, which is derived from the root of the plant
Curcuma
longa, has been described as a treatment for diabetes in Ayurvedic and
traditional Chinese medicine for thousands of years. “Recent research
has
provided the scientific basis for “traditional†curcumin and
confirmed the
important role of curcumin in the prevention and treatment of diabetes
and its
associated disorders. Curcumin could favourably affect most of the
leading
aspects of diabetes, including insulin resistance, hyperglycaemia,
hyperlipidaemia, and islet apoptosis and necrosis.†Curcumin
Potentiates
Laryngeal Squamous Carcinoma Cancer Journal of Receptors and Signal
Transduction, July
2020
Curcumin has shown efficacy in promoting radiosensitivity combined with
radiotherapy. Curcumin significantly enhanced irradiation-induced DNA
damage
and apoptosis, while weakening clone-forming abilities of LSCC cell
line Hep2
and Hep2-max. Compared to Hep2 cells, Hep2-max cells are more sensitive
to
curcumin post-irradiation. Curcumin enhances LSCC radiosensitivity via
NF-ΚB
inhibition by suppressing IKKγ expression. Curcumin For Better Memory?
drweil.com July
2020
Curcumin is a compound found in the spice turmeric. Both give the
yellow color
to curry powder and American mustard. The possibility that curcumin
could
prevent – or treat – memory problems, including Alzheimer’s
disease, is
suggested in part by population studies showing that elderly villagers
in India
have the world’s lowest rate of Alzheimer’s, perhaps because their
traditional diet provides turmeric with almost every meal. Curcumin is a
powerful antioxidant and also has anti-inflammatory properties that
might
protect against Alzheimer’s, which begins as an inflammatory process
in the
brain. The latest findings on curcumin’s effects come from a small,
double-blind, placebo-controlled UCLA study showing that curcumin
supplements
improved memory and mood in 40 people between the ages of 51 and 84
with mild,
age-related memory loss. The participants were randomly assigned to
receive
either 90 milligrams of an easily absorbed form of curcumin twice daily
for 18
months or a placebo. The form of curcumin used in this study is key;
many forms
are not well absorbed from the GI tract, so that little gets into the
bloodstream and even less gets past the blood-brain barrier. All the
UCLA study
participants received standardized cognitive assessments when the study
began
and every six months afterwards. In addition, 30 of them had PET scans
at the
investigation’s beginning and end to determine their levels of
amyloid-beta
and tau, the abnormal proteins that make up the plaques and tangles
that
progressively obstruct cerebral function in Alzheimer’s disease. At
the end
of the study, the team found that memory improved by 28 percent in the
participants who took curcumin. No such changes occurred in those who
received
the placebo. Those who took curcumin also showed mild improvements in
mood, and
their PET scans revealed significantly less amyloid and tau proteins in
brain
regions that control memory and emotional functions. In news reports,
the
study’s first author, Gary Small, M.D., director of geriatric
psychiatry at
UCLA’s Longevity Center, said it isn’t known exactly how curcumin
exerts
theSE effects, but they may be due to its ability to reduce brain
inflammation,
A factor in both Alzheimer’s disease and major depression. Managing
autoimmune disorders Times Of India, July
2020
Curcumin is the main active ingredient in turmeric. It has powerful
anti-inflammatory effects and is a very strong antioxidant. It helps
the body
fight foreign invaders and also has a role in repairing damage.
Circumin helps
fight many autoimmune diseases. It not just neutralizes free radicals
on its
own but also stimulates the body's own antioxidant enzymes. Curcumin
leads to
various changes at the molecular level that may help prevent and even
heal a
cancer. Struggle with Schizophrenia? Curcumin May Make the Difference
Natural
Path Newsletter, July
2020
To see if curcumin could widen the treatment to include the negative
symptoms
of schizophrenia, researchers added either a placebo or 3g of curcumin a
day to
the antipsychotic drugs of 38 people with chronic schizophrenia in a
double-blind study. At the end of the six month study, there was a
significantly better response in the curcumin group on the Positive and
Negative Symptoms Scale (PANSS) and on the negative symptoms subscale.
The
researchers call these results “promising†because they suggest a
safe,
effective, natural way of addressing the previously resistant negative
symptoms
of schizophrenia. Antibacterial Mechanism of Curcumin: A Review
Chemistry &
Biodiversity, July
2020
Curcumin is a plantâ€derived polyphenolic active substance with
broadâ€spectrum antibacterial properties. Curcumin blocks bacterial
growth
owing to its structural characteristics and the generation of
antiâ€oxidation
products. Curcumin can inhibit bacterial virulence factors, inhibit
bacterial
biofilm formation and prevent bacterial adhesion to host receptors
through the
bacterial quorum sensing regulation system. Moreover, it can exert a
synergistic antibacterial effect with other antibacterial substances.
In this
review, we summarize the research progress on the antibacterial
mechanism of
curcumin based on five targeting structures and two modes of action.
Our
discussion provides a theoretical basis and technical foundation for
the
development and application of natural antibacterial agents. Benefits
of using
Turmeric bolnews, July
2020
Turmeric dramatically increases the antioxidant capacity of the body.
The main
reason antioxidants are so beneficial is that they protect your body
from free
radicals. Curcumin is a potent antioxidant that can neutralize free
radicals
due to its chemical structure. Turmeric boosts levels of the brain
hormone
BDNF, which increases the growth of new neurons and fights various
degenerative
processes in your brain. Turmeric leads to several changes on the
molecular
level that may help prevent and perhaps even treat cancer. Curcumin
ameliorates
CKD-induced mitochondrial dysfunction and oxidative stress The Journal
of
Nutritional Biochemistry, July
2020
Curcumin could exert beneficial effects, including weight maintenance
and
improved muscle function, increased mitochondrial biogenesis,
alleviated
mitochondrial dysfunction by increasing adenosine triphosphate levels,
activities of mitochondrial electron transport chain complexes and
basal
mitochondrial respiration and suppressing mitochondrial membrane
potential. In
addition, curcumin modulated redox homeostasis by increasing
antioxidant
activity and suppressed mitochondrial oxidative stress. Moreover, the
protective effects of curcumin had been found to be mediated via
inhibiting
GSK-3β activity in vitro and in vivo. Importantly, GSK-3β KO
contributed to
improved mitochondrial function, attenuated mitochondrial oxidative
damage and
augmented mitochondrial biogenesis in muscle of CKD. Overall, this
study
suggested that curcumin alleviated CKD-induced mitochondrial oxidative
damage
and mitochondrial dysfunction via inhibiting GSK-3β activity in
skeletal
muscle. How to live longer express.co.uk, July
2020
In a study with the US National Library of Medicine National Institutes
of
Health, turmeric extract and its active compound, curcumin and how it
can help
with liver damage was investigated. The study noted: “Curcumin, a
major
active component of turmeric, has previously been reported to alleviate
liver
damage. “We hypothesized that turmeric extract and curcumin protect
the liver
by reducing oxidative stress, inhibiting lipid peroxidation.†The
study found
that curcumin can protect against liver damage and that potential liver
and
gallbladder benefits of curcumin include increasing production of the
digestive
fluid bile while also protecting liver cells from damage from
bile-associated
chemicals. Studies on Curcumin with COVID-19 Proteins Biochemistry,
June
2020
Curcumin, a natural bioactive molecule has been shown to have a
therapeutic
potential for various diseases, but no role of it in COVID-19 has been
explored. In this work, we show the binding potential of curcumin
targeted to a
host of SARS-CoV-2 proteins. Our results indicate that curcumin has
potential
antiviral protein binding affinity towards SARS-CoV-2 proteins which is
comparable with other repurposed drugs that are considered for clinical
trials.
Effects of curcumin on neurological diseases Pharmacological Reports,
June
2020
Curcumin, the major active component of turmeric, belongs to the
curcuminoid
family that was originally isolated from the plant Curcuma longa.
Several
studies suggest that curcumin may have a beneficial impact on the brain
pathology and aging. These effects are due to curcumin’s antioxidant,
free-radical scavenging, and anti-inflammatory activity. In light of
this, our
current review aims to discuss the role of astrocytes as essential
players in
neurodegenerative diseases and suggest that curcumin is capable of
direct
inhibition of astrocyte activity with a particular focus on its effects
in
Alexander disease, Alzheimer's disease, ischemia stroke, spinal cord
injury,
Multiple sclerosis, and Parkinson’s disease. Effects of curcumin on
breast
cancer cell proliferation International Journal of Oncology, June
2020
Only curcumin and B(Cur)2 inhibited cell migration. Furthermore, cell
exposure
to curcumin resulted in an increase in the relative expression of the
two key
proapoptotic proteins, cytochrome c and cleaved caspase‑3, as well as
the
antiapoptotic protein haem oxygenase‑1. In addition, curcumin
increased the
expression levels of the voltage‑gated potassium channels Kv2.1 and
Kv3.2.
Similarly, the expression levels of the chloride channel bestrophin‑1
and the
calcium channel coding gene calcium voltage‑gated channel auxiliary
subunit
γ4 were increased following exposure to curcumin. Fe(Cur)3 and B(Cur)2
may
display similar anticancer properties as curcumin. Curcumin's potential
to
fight COVID-19 Manorama Online, June
2020
Curcumin is an integral part of two among the three research projects
undertaken by MG varsity VC and his team of scientists Consequences of
long-term low-dose curcumin exposure in lung cancer cells Molecules,
June
2020
Curcumin has been investigated extensively for cancer prevention, but
it has
been proposed that long-term treatments may promote clonal evolution
and gain
of cellular resistance, potentially rendering cancer cells less
sensitive to
future therapeutic interventions. Curcumin (0.25–0.5 µM) was able to
inhibit
the invasion of both native and chemo-resistant NSCLC cells in the
organotypic
co-culture model. Local doctor says food, spices in your home could
boost your
immunity Boston 25 News, June
2020
A recent New York Times article said that most Americans don’t have
the diet
or overall health to fight COVID-19. A Weymouth doctor said a strong
immune
system is needed to fight the virus. Dr. Pat Hopkins, a rheumatologist
and
director of the Boston Functional Medicine Group, looks at the root
cause of
diseases. “I always like to say the best offense is a good defense so
you’re building up your immune system,†Hopkins said. “If you get
the
virus your immune system should roll over and say no problem.â€
Hopkins said
the best way to flatten the curve and protect yourself from
coronavirus.
Here’s a list of Hopkins’ top supplements to help boost your
immunity:
Curcumin, 500 to 1000 MG twice a day. Bioactive immunity booster
PinkVilla.com
June
2020
The key substance which makes turmeric so useful and powerful is
Curcumin. Due
to its antioxidant, anti-inflammatory, and antimicrobial properties, it
aids to
combat inflammation, which is the origin of many chronic diseases in
the body
and also lessens immunity. It has also proven to be a super ingredient
to
strengthen joints, have a stronger heart, sharper brain, and a healthy
liver.
Curcumin is also effective for healthy and glowing skin and its
consumption
keeps viruses and infections at bay. Curcumin ameliorates CKD-induced
mitochondrial dysfunction and oxidative stress through inhibiting
GSK-3β
activity The Journal of Nutritional Biochemistry, June
2020
Curcumin has been reported to attenuate muscle atrophy. Moreover, the
protective effects of curcumin had been found to be mediated via
inhibiting
GSK-3β activity in vitro and in vivo. Importantly, GSK-3β KO
contributed to
improved mitochondrial function, attenuated mitochondrial oxidative
damage, and
augmented mitochondrial biogenesis in muscle of CKD. Overall, this
study
suggested that curcumin alleviated CKD - induced mitochondrial
oxidative damage
and mitochondrial dysfunction via inhibiting GSK-3β activity in
skeletal
muscle. Antiviral Foods To Boost Your Immune System Refinery29.com June
2020
Curcumin, a compound found in turmeric, has powerful anti-inflammatory
properties. Davis says that even low doses of it enhances antibody
responses,
an indicator that your body is fighting off illnesses. You can cook
with
turmeric, a spice, but you can find curcumin supplements at any health
food
store too. Lower concentrations of curcumin inhibit Her2-Akt pathway
components
in human breast cancer cells Nutrition Research, June
2020
Curcumin has emerged as a potential co-treatment for this and other
cancers,
but prior studies have focused on non-attainable concentrations. These
studies
demonstrate that a physiological attainable level of curcumin (1.5 μM)
can
reduce some components of the critical Her2-Akt pathway; that even more
complete inhibition can be achieved by combination with other dietary
botanicals; and that curcumin and other botanicals can potentiate the
action of
the human epidermal growth factor receptor 2 cancer metastatic drug
lapatinib,
in turn suggesting the potential anti-cancer clinical use of these
botanicals.
Curcumin for the Management of Periodontal Diseases: A Review Current
Pharmaceutical Design, June
2020
Periodontal disease is one of the most common causes of tooth loss
among
adults. Research shows that inflammation is one of the crucial
components in
the initiation and progression of periodontitis. Various herbal
medicines have
recently been receiving attention for the management of periodontitis
owing to
their general safety and efficacy. Curcumin, a bioactive polyphenol
extracted
from Curcuma longa, has been shown to possess antioxidant,
antimicrobial,
anti-inflammatory and analgesic properties. Several studies have
assessed the
efficacy of curcumin against periodontal diseases. These studies have
shown
equivalent or even higher efficacy of curcumin compared to the commonly
used
medications for the management of periodontitis such as chlorhexidine.
Herein,
we review the experimental and clinical findings on the
anti-periodontitis
effects of curcumin and the pharmacological mechanisms underlying these
effects. The Best Anti-Aging Supplements For Longevity Longevity Live,
June
2020
Curcumin is responsible for the vibrant yellow color of turmeric. With
its
anti-inflammatory effects, curcumin could be exactly what your aged
skin needs.
In fact, one study associated turmeric intake with a reduced risk of
age-related mental decline in humans. A separate study published in the
Phytotherapy Research journal found that the topical application and
oral
ingestion of curcumin supplements helped to alleviate the appearance of
not
only aging, but that of skin damage caused by UV rays. Curcumin
alleviates
OGD/Râ€induced PC12 cell damage via repressing CCL3 to suppress
inflammation
and apoptosis Journal of Pharmacy and Pharmacology, June
2020
Curcumin presents some therapeutic effects including antiâ€cancer and
antiâ€inflammation. Herein, we centered on the functional role of
curcumin in
cerebral ischaemia injury and its potential molecular mechanisms. Our
study
manifested that curcumin might be a meritorious drug for the treatment
of
cerebral ischaemia by acting on CCL3. Best supplements for diabetes -
the
'amazing' capsules to protect against high blood sugar Express, June
2020
Curcumin improves insulin resistance in some diabetes patients,
according to
nutritionist Dr Sarah Brewer. The spice could also protect against some
of the
severe complications of high blood sugar. Its anti-inflammatory
properties mean
that patients aren't as likely to develop neuropathy, or damage to
their blood
vessels. People with prediabetes could also benefit from taking
turmeric
supplements, added the nutritionist. "Curcumin supplements have also
been shown
to improve insulin resistance by activating insulin receptors. "In
people with
poor glucose tolerance [prediabetes], turmeric can delay the onset of
type 2
diabetes. "These are amazing results and it’s no wonder that turmeric
is an
increasingly popular natural treatment for type 2 diabetes." Curcumin
inhibited
mitochondrial apoptosis induced by PCV2 virus Research Square, June
2020
Curcumin has significant antiviral effect. And the PCV2-induced
Mitochondrial
apoptosis was mainly remitted by Curcumin. Putting health first Daily
Pioneer,
June
2020
Known for its anti-oxidant and anti-inflammatory properties, Curcumin,
the
compound present in turmeric is a very potent agent and aids in healing
of
wounds and infections. This bright yellow, bitter spice has also been
used for
years as an anti-inflammatory in treating both osteoarthritis and
rheumatoid
arthritis. Research shows that high concentrations of curcumin, which
gives
turmeric its distinctive color, can help decrease exercise-induced
muscle
damage. Curcumin has promise as an immune booster (based on findings
from
animal studies) and an antiviral. Curcumin (Diferuloylmethane) Induces
Apoptosis in Mantle Cell Lymphoma Biochemical Pharmacology, June
2020
We used curcumin, a pharmacologically safe agent, to target NF-kappaB
in a
variety of MCL cell lines. On treatment of cells with curcumin,
however,
downregulated constitutive active NF-kappaB and inhibited the
consitutively
active IkappaBalpha kinase (IKK), and phosphorylation of IkappaBalpha
and p65.
Curcumin also inhibited constitutive activation of Akt, needed for IKK
activation. Consequently, the expression of all NF-kappaB-regulated
gene
products, were downregulated by the polyphenol leading to the
suppression of
proliferation. Overall, our results indicate that curcumin inhibits the
constitutive NF-kappaB and IKK leading to suppression of expression of
NF-kappaB-regulated gene products that results in the suppression of
proliferation, cell cycle arrest, and induction of apoptosis in MCL.
Exercise
and Curcumin in Combination Improves Cognitive Function and Attenuates
ER
Stress in Diabetic Rats Nutrients, June
2020
Curcumin is a natural compound with known antioxidant and
anti-inflammatory
properties. Exercise plus curcumin improved escape latency and memory
retention
compared to OLETF controls. Furthermore, OLETF rats exercised and fed
curcumin
had lower IL6, TNFα, and IL10 levels (indicators of inflammatory
response) and
lower levels of ER stress markers (BiP and CHOP) in the intestine than
OLETF
controls. These observations suggest exercise plus curcumin may offer a
means
of treating diabetes-related cognitive dysfunction. Curcumin
Administration
Mitigates Oxidative Damage and Restores Alteration of Enzymes
Associated with
Cognitive Function in Rats’ Brain Neurotoxicity Research, June
2020
Curcumin also improved redox balance and showed protection against
cyclophosphamide-induced oxidative damage to rats’ brain via an
increase in
protein and non-protein thiols and nitric oxide levels as well as a
significant
reduction in malondialdehyde levels. Curcumin also prevented neuronal
degeneration in different brain regions and reduced caspase-3
expression. Hence
this study suggests that pre and post-treatment with curcumin improved
neurobehavior, modulates some biomarkers associated with cognitive
function and
exhibit neuroprotection against cyclophosphamide-induced neurotoxicity
in rats.
Curcumin Confer Radiosensitizing Effect in Breast Cancer American
Journal of
Biochemistry and Molecular Biology, May
2020
Curcumin reduced the proliferation rate of cells. Correspondingly,
wound
healing assay resulted in control of the cell-cell interaction and cell
migration at two different time points. Conclusion: In conclusion,
curcumin
along with a lower dose (8 Gy) of radiation acted as the best
combinatorial
drug treatment for breast cancer cell lines. Our findings put up a
rationale
for further clinical/preclinical analysis of combination treatments
with a
lower dose and fewer side effects in breast cancer. COVID-19: Herbs
That
Strengthen Your Immune System outlookindia, May
2020
Turmeric contains a bioactive compound known as curcumin, which acts as
an
anti-inflammatory agent. Curcumin effect on cancer cells Phytotherapy
Research,
May
2020
Curcumin is a natural phenolic compound which shows potent anticancer
activities in different tumors, alone or as an adjuvant with other
antitumor
drugs to prevent or inhibit the survival and cancer progression by
various
mechanisms. The role of curcumin in overcoming drug resistance was
followed by
reviewing different applications of curcumin in cancer therapy.
Afterward, the
clinical impacts of curcumin, role of curcumin in decreasing drug
resistance in
different cancer cells and its mechanisms were discussed. It has been
demonstrated that curcumin regulates signaling pathways in cancer
cells,
reduces the expression of proteins related to drug resistance, and
increases
the performance of antitumor drugs at various levels. Curcumin reverses
multidrug resistance mechanisms and increases sensitivity of resistance
cells
to chemotherapy. This review mainly focuses on different mechanisms of
drug
resistance and curcumin as a nontoxic natural substance to eliminate
the
effects of drug resistance through modulation and controlling cell
resistance
pathways and eventually suggests curcumin as a potent chemosensitizer
in
cancers. Benefits Of Turmeric You Might Not Have Known republicworld,
May
2020
Turmeric is rich in curcumin; it can reduce inflammation by blocking
enzymes
that cause tissue inflammation. Curcumin has powerful antioxidant
effects. It
helps to reduce or even prevent some of the potential damage that free
radicals
can cause. According to recent research by Healthline, turmeric's
antioxidant
and anti-inflammatory capacity mostly related to its compound curcumin
may play
a role in weight loss. Chemopreventive effect of green tea and curcumin
in
induced oral squamous cell carcinoma Alexandria Dental Journal, May
2020
Curcumin, a natural polyphenol, is one of the most investigated
biomolecules
from Mother Nature. Curcumin has been shown to exert significant growth
inhibitory effect on oral precancerous and carcinoma cell lines, and
the effect
is synergistic with epigallocatechin gallate, the most abundant
polyphenol in
tea. Conclusions: Green tea and curcumin have a significant
chemopreventive
effect against oral cancer. Investigation of phytochemical screening
and
antimicrobial activity of Curcuma longa International Journal of
Advanced
Research in Biological Sciences, May
2020
Many plants have been screened for antimicrobial activity and drug
properties.
The aim of the present study encourages the use of spices as
alternative or
supplementary medicine to reduce the burden of high cost, side effects
and
progressively increasing drug resistance of pathogens. In present study
methanol and chloroform extracts of Curcuma longa (fresh and dry) were
prepared
from the rhizome. The antimicrobial properties of both of the extract
were
studied by testing the antibacterial as well as antifungal activity.
The
antibacterial test was done by agar well diffusion method against
bacterial
species such as Escherichia coli, Staphylococcus aureus, Klebsiella
pneumoniae,
Protease vulgaris, Pseudomonas aeruginosa, Bacillus cereus, Bacillus
megatarium, Bacillus subtilis and fungal species such as Aspergillus
niger. The
zone of inhibition of the extract were determined and compared with the
standard drug streptomycin to know the efficiency. The methanol extract
of
rhizome was found to be more effective when compared with other solvent
like
chloroform. The phytochemical analysis of both of the extract revealed
the
presence of alkaloids, flavonoids, terpenoids, tannins, saponin and
steroids.
Protective effects of curcumin on bleomycin-induced changes in lung
glycoproteins Molecular and Cellular Biochemistry, May
2020
Curcumin inhibited the increases in complex carbohydrates and
glycosidases in
the fibrotic lungs. These findings suggest that BLM-induced lung
fibrosis is
associated with accumulation of glycoproteins, and curcumin has the
ability to
suppress the enhanced deposition of glycoproteins in the fibrotic lung.
Nutrition: Is turmeric good for you? newtimes, May
2020
They say turmeric and its most active compound known as curcumin has
many
scientifically-proven health benefits, such as the potential to prevent
heart
disease, Alzheimer’s and cancer, as well as a potent
anti-inflammatory and
antioxidant. Nutritionists say the primary active component of turmeric
and the
one that gives the spice its characteristic yellow colour is curcumin.
In fact,
they say that one can credit curcumin as the compound responsible for
most of
turmeric’s potential health benefits. Studies have shown that
curcumin found
in turmeric is an effective anti-carcinogen, a substance that helps
prevent
cancer. Besides, Uwiragiye notes that the medicinal property in
turmeric is
able to boost the immune system, even in people with immune disorders.
During
this time when we are faced with the novel coronavirus, it’s
essential for
people to consume foods that help in boosting their immunity, and
turmeric
should be one of them. This is because it has been proven that the
virus
affects people with the low immune system more. Research shows that the
curcumin found in turmeric may help prevent Alzheimer’s, and,
turmeric’s
antioxidants prevent damage that can lead to Alzheimer’s. Meanwhile,
studies
have proven that curcumin in turmeric may help treat and prevent
diabetes as
well as associated disorders like diabetic nephropathy (also called
diabetic
kidney disease), which affects people with type 1 and 2 diabetes.
Effects of
Curcumin on the Renal Toxicity Antioxidants, May
2020
Curcumin (CURC), due to its therapeutic effects, has been chosen for
our study
to reduce the toxic renal effects induced by OTA. This study shows that
curcumin can mitigate OTA-induced oxidative damage in the kidneys of
rats.
COVID-19: Scientific Review with Natural & Holistic Methods for
Immune Boosting
ModernHana, April
2020
CURCUMIN This chemical from the Indian spice, Tumeric, does many good
things
for the body. Kang et al
2019
study titled Curcumin inhibits Th1 cytokine profile in CD4+ T cells by
suppressing interleukin-12 production in macrophages†published in
the
British Journal of Pharmacology suggest that Curcumin can likely help
reduce
excess inflammation (cytokine storm) in the lungs. Jagetia GC and
Aggarwal BB ,
2007
study titled “ "Spicing up" of the immune system by curcuminâ€
published in
the Journal Clinical Immunology also suggests that Curcumin has potent
immune
benefits that can help fight infections. A cost-effective preventative
approach
to potentially save lives in the coronavirus pandemic, jointly using
Vitamin D,
Curcumin, and Vitamin C NutriXiv, April
2020
In the current absence of specific pharmaceutical agents, we propose
assessing
the extended tools that we already possess in our biological armoury to
combat,
prevent and control the spread of this virus. Using a set of precise
criteria
to locate such possible contenders, we conducted literature searches to
find
compounds that met these criteria. We have now reduced this to a
shortlist of
three agents that may be the best candidates. We propose vitamin C,
vitamin D
and Curcumin fit our criteria well. These compounds are widely
available to the
general public. They are available online and over-the-counter as
supplements.
Otherwise healthy individuals are safely able to self-administer these
agents
as a prophylactic to protect themselves and to enhance their immune
response.
This would be especially desirable for the elderly and at risk groups.
These
agents can also be used as adjunct therapy, particularly for those who
may have
early symptoms. This preventative therapy could be implemented whilst
awaiting
specific pharmaceutical drugs to emerge as a treatment for COVID-19.
Our
suggested compounds are a highly cost-effective way to potentially
reduce the
mortality that is regretfully mounting as a result of COVID-19
infection.
Enhance Your Immunity Amid Coronavirus Crisis Medical Daily, April 20
"Turmeric
has antiseptic, analgesic and immune boosting properties (that serve)
as a line
of defense against colds, flu and inflammation due to the active
polyphenol
called curcumin," Amanda Griggs, nutritionist at the Khera-Griggs
Cleanse
Clinic at the Urban Retreat in London, explained. Application of
curcumin and
its derivatives in tumor multidrug resistance Phytotherapy Research,
April
2020
Curcumin (CUR) has not only antitumor activity but also reversing tumor
MDR
effect. CUR reverses tumor MDR via regulating related signal pathways
or
corresponding expressed proteins or gene. When combined with
chemotherapeutic
agents, CUR can be a chemotherapeutic sensitive agent to enhance
chemotherapy
efficacy and weaken tumor MDR. Dietary Supplementation with Curcumin
Reduce
Circulating Levels of Glycogen Nutrients, April
2020
Dietary supplementation with curcumin has been previously reported to
have
beneficial effects in people with insulin resistance, type 2 diabetes
(T2D) and
Alzheimer’s disease (AD). Dietary supplementation with curcumin
reduced
circulating levels of IAPP and GSK-3β, thus suggesting a novel
mechanism
through which curcumin could potentially be used for alleviating
insulin
resistance related markers for reducing the risk of T2D and AD.
Curcumin
Reverses the Scopolomine-induced Cognitive Impairment International
Journal of
Pharmaceutical Sciences and Drug Research, April
2020
Curcumin is a polyphenolic compound, known for its antioxidant,
anti-inflammatory, neuroprotective, and precognitive properties.
Present study
reported that curcumin showed anti-amnesic effect in animal models of
cognitive
impairment of schizophrenia. Curcumin reduced the TL compared to toxic
control
group (scopolamine per se) (P <0.001) in elevated plus maze. In
spontaneous
alteration behaviour test, curcumin significantly increased percentage
alteration and possible alteration as compared to toxic control group
(P
<0.001). The present study put forward the claim of curcumin as a
new and safer
therapeutic option for the treatment of cognitive impairment in
Schizophrenia.
The underlying mechanism of this potential effect may be related to
anticholinesterase and nitric oxide synthase inhibition activity of
curcumin.
Curcumin and Endometriosis International Journal of Molecular Sciences,
April
2020
Curcumin is a major anti-inflammatory agent. Several findings have
highlighted
the anti-oxidant, anti-inflammatory and anti-angiogenic properties of
curcumin.
The purpose of this review is to summarize the potential action of
curcumin in
endometriosis by acting on inflammation, oxidative stress, invasion and
adhesion, apoptosis and angiogenesis. Type 2 diabetes: Curry spice to
add to
foods to lower blood sugar Express, April
2020
A scientific paper from the Beijing University of Chinese Medicine and
McGill
University reviewed studies of how curcumin from the around the world
could
help with better type 2 diabetes management. In many of the studies it
was
found that curcumin reduced blood sugar and cholesterol levels for
those with
diabetes. Curcumin was found to improve insulin function which reduces
insulin
resistance by helping them enter the cells needed to repair and do its
function. On top of helping lower blood sugar levels and improve
insulin
functions, curcumin was also found to be an excellent weight loss
booster.
Health experts found that curcumin prevented liver fat accumulation in
studies
on rats. It found that rats who consumed curcumin had reduced liver fat
on a
high-fat diet compared to rats not consuming curcumin and aided in
weight loss.
One of the best type 2 diabetes management one could do is lose weight
if
overweight and curcumin could help with this. The studies also found
that
curcumin helped to fight off cancers and even helped those suffering
with
erectile dysfunction. Ward off your cancer risk with spices The Health
Site,
April
2020
Good old turmeric is your has been your kitchen companion forever.
Almost all
your dishes have turmeric in them. The good news is, curcumin, a
component of
turmeric can reduce your cancer risk, finds a spate of studies. A study
published in the journal Gastroenterology found that this compound
prevented
the growth of colon cancer tumours. Curcumin is also known to protect
you from
other Alzheimer’s, diabetes, arthritis pain, etc. Coronavirus
Pandemic:
Here’s How to Boost Your Immunity at Home News18, March
2020
Turmeric: A common spice in India and Asia. Turmeric contains curcumin
which is
known to enhance immune function. Adding turmeric to your food will
help you
boost your immunity. Tips on Staying Safe During the COVID-19 Outbreak
by a
Doctor The Quint, March
2020
The active ingredient curcumin has been shown in several studies to
stop the
‘cytokine storm’ of pro-inflammatory chemicals in the body, in the
earlier
epidemics of SARS and Ebola viruses. What can I do to boost my
immunity? Is
there any medication able to treat coronavirus? COVID-19 questions
answered by
Cleveland Clinic doctor WKYC, March
2020
Dr. Roizen: There are a lot of things that boost immunity. Vitamin D is
one of
those reported to boost immunity. Curcumin is reported to boost it. A
recent
study by Indonesia's Airlangga University suggested curcumin — a
component of
turmeric — could reduce inflammation in the lungs and help boost
immunity
against the virus. ABC, March
2020
Protect your body against coronavirus InfoSurhoy, March
2020
Consuming anti-inflammatory rich foods is essential when it comes to
the immune
system.. The compound in turmeric known as curcumin holds a plethora of
benefits. Precaution and prevention best medicines to avoid Covid-19
Times of
India, March
2020
Dr Varinder and Dr Naveen Airi specified that there there is no
treatment for
Coronavirus. The only way to prevent is to boost immunity via homeopath
medicines like Ginseng, Curcumin Turmeric, or curcumin, known for
reducing
inflammation in the body, can help fight off coronavirus, according to
some
medical experts IndiaWest, March
2020
NEW DELHI – Turmeric, or curcumin, is being advocated by some medical
experts
for reducing lung inflammation amid the rising COVID-19 cases in India.
The
virus is especially known to attack the respiratory system. Turmeric is
being
touted as the only way to keep inflammation in your body low so that
you have a
better chance of fighting the coronavirus infection. "Curcumin (a
diferuloylmethane) was found to be the most widely studied compound as
evinced
by more than 9000 citations in the literature, with antioxidant,
anti-inflammatory, anticancer, antiviral, antibacterial, antidiabetic,
antiarthritic, antiatherosclerotic, antidepressant, antiaging,
antimicrobial,
wound healing and memory-enhancing activities. Moreover, it exerts
chemopreventive, chemosensitization and radiosensitization effects as
well. In
traditional Indian medicine, this spice has been also used to treat
different
ailments such as gynecological problems, gastric problems, hepatic
disorders,
infectious diseases, blood disorders, acne, psoriasis, dermatitis, rash
and
other chronic ailments. Diverse in vivo studies have also indicated its
potential against pro-inflammatory diseases, cancers, neurodegenerative
diseases, depression, diabetes, obesity and atherosclerosis. Besides
its safety
and tolerability, cost-effectiveness is an added advantage of this
compound. To
date, over 100 different clinical trials have been completed with
curcumin,
which clearly show its safety, tolerability and its effectiveness
against
various chronic diseases in humans." - British Journal of Pharmacology
"7,000
published articles have shed light on the various aspects of curcumin
including
its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer
activities.
Oxidative stress and inflammation play a pivotal role in various
diseases like
diabetes, cancer, arthritis, Alzheimer's disease and cardiovascular
diseases."
- Food and Chemical Toxicology Journal "6.000 articles published within
the
past two decades have discussed the molecular basis for the
antioxidant,
anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer
activities assigned to this nutraceutical. Over sixty five clinical
trials
conducted on this molecules, have shed light on the role of curcumin in
various
chronic conditions, including autoimmune, cardiovascular, neurological,
and
psychological diseases, as well as diabetes and cancer." -
Biotechnology
Advances Journal "Curcumin has been used as pharmacological traditional
medicinal agent in Ayurvedic medicine for 6000 years. The current
review
article presents effective role of curcumin against cancer, diabetes,
oxidative stress, cardiovascular, obesity, and aging. Curcumin is a
promising
and signiï¬cant natural bioactive compound which has been shown to
possess
numerous pharmacological activities including anticancer, antidiabetic,
cardiovascular protective, antiobesity, antimicrobial, wound healing,
and
nephroprotective activities. The molecule has also potential to protect
from
reproductive and respiratory disorders in association with its strong
antioxidant potential. In near future, curcumin is expected to be
proven as a
novel drug to treat and cure several human disorders such as
carcinogenesis,
inflammatory disorders, and oxidative stress-induced pathogenesis." -
Trends
in Food Science & Technology Turmeric to resist COVID-19 Saxon,
March
2020
Turmeric. Its main component curcumin is considered a powerful immune
booster,
acts as an anti-inflammatory. Curcumin Inhibits the Tumorigenesis of
Breast
Cancer Cancer Management and Research, March
2020
Curcumin is an active phenolic pigment that is isolated from turmeric
(Curcuma
longa). Curcumin has diverse properties on tumor cells, including
anti-proliferation, anti-inflammatory, and anti-oxidant. Previous
studies have
shown that curcumin can effectively suppress the invasion and
proliferation of
human cancers, such as wilms’ tumor (WT) esophageal cancers, and
pancreatic
cancer. Jia et al have found that the proliferation, invasion and
migration of
WT cells are restrained by the treatment of curcumin. Dharmalingam et
al have
shown that curcumin treatment inhibits the proliferation and colony
formation
of esophageal cancer cells in a dose and time-dependent manner.
Choudhuri et al
have proved that curcumin induces the apoptosis of BC cells. In
addition, Bang
and Kim have confirmed that curcumin significantly inhibits the
motility and
invasion of BC cells. The anti-tumor role of curcumin has been
identified by a
large number of researches. Curcumin (20 and 30 μM) inhibited the
proliferation, migration and invasion, and promoted the apoptosis of
MCF-7 and
MDA-MB-231 cells. Curcumin decreased the protein expression of TAZ and
YAP in
MCF-7 and MDA-MB-231 cells. Overexpression of YAP reversed the
anti-tumor
effect of curcumin on MDA-MB-231 cells. In addition, curcumin (100, 200
and 300
mg/kg/d) inhibited the growth of tumor xenografts in mice, and
down-regulated
the protein expression of TAZ and YAP in tumor xenografts. Curcumin at a
concentration of 300 mg/kg/d slowed the increasing of body weight in
mice.
Conclusion: Curcumin inhibited the tumorigenesis of BC by blocking
TAZ/YAP axis
Curcumin and Colorectal Cancer: An Update and Current Perspective On
This
Natural Medicine Seminars in Cancer Biology, March
2020
Curcumin, derived from the plant Curcuma longa, represents one such
option that
has a long history of its use for a variety of chronic disease
including
cancer, in Indian ayurvedic and traditional Chinese medicine.
Scientific
evidence over the past few decades have overwhelmingly shown that
curcumin
exhibits a multitude of anti-cancer activities orchestrated through key
signaling pathways associated with cancer. In this article, we will
present a
current update and perspective on this natural medicine - incorporating
the
basic cellular mechanisms it effects and the current state of clinical
evidence, challenges and promise for its use as a cancer preventative
and
potential adjunct together with modern therapies for CRC patients.
Therapeutic
Effects of Curcumin against Bladder Cancer Anti-Cancer Agents in
Medicinal
Chemistry, March
2020
Curcumin is a well-known plant-derived polyphenol found in turmeric.
This
compound has numerous pharmacological effects such as antioxidant,
anti-inflammatory, anti-diabetic and anti-tumor properties. Curcumin is
capable
of suppressing the growth of a variety of cancer cells including those
of
bladder cancer. Given the involvement of various signaling pathways
such as
PI3K, Akt, mTOR and VEGF in the progression and malignancy of bladder
cancer,
and considering the potential of curcumin in targeting signaling
pathways, it
seems that curcumin can be considered as a promising candidate in
bladder
cancer therapy. In the present review, we describe the molecular
signaling
pathways through which curcumin inhibits invasion and metastasis of
bladder
cancer cells. Coronavirus: Antiviral Cationic Carbon Dots Based on
Curcumin ACS
Publications, March
2020
Here, we report a one-step method to apply curcumin in order to prepare
of
uniform and stable cationic carbon dots (CCM-CDs) with antiviral
properties.
These results offer theoretical support for the development of CCM-CDs
as a
hopeful antiviral drug for the treatment of coronavirus infections,
including
PEDV. In the fight against cancer: Scientists say compound curcumin
found in
the popular spice has tumour-killing potential DailyMail, March
2020
Scientists analyzed almost 5,000 studies and found curcumin blocked the
growth
of eight types of cancers, under laboratory settings. Results showed it
was
effective at treating breast, lung, blood, stomach, pancreatic, bowel,
bone
marrow and prostate cancer. The academics from Temple University in
Philadelphia say curcumin stops nutrients from being transported to
tumours.It
also prevents the death of healthy cells by blocking cancer cells from
releasing harmful proteins. The academics concluded curcumin - the
pigment in
turmeric that gives it its colour - could 'represent an effective drug
for
cancer treatment. Curcumin Attenuates Colistin-Induced Peripheral
Neurotoxicity
ACS Infectious Diseases, March
2020
Orally applied curcumin was detected in the brain, cerebellum, and
sciatic
nerve. Co-administration of oral curcumin markedly improved
colistin-induced
impaired sensory and motor dysfunctions in a dose-dependent manner.
Curcumin
supplementation at 100 and 200 mg/kg significantly decreased lipid
peroxidation
and upregulated catalase (CAT) and superoxide dismutase (SOD)
activities, ATP
levels, and Na+/K+-ATPase activity in sciatic nerve tissue, compared to
the
colistin alone group. Curcumin supplementation at 200 mg/kg upregulated
the
levels of AKT, NGF, mTOR, Nrf2, and HO-1 mRNA and concomitantly
downregulated
Bax, caspases-3, and -9 mRNA; it also decreased caspase-3 and caspase-9
activity. In summary, for the first time, our study reveals that the
protective
effect of oral curcumin on colistin induced peripheral neurotoxicity is
associated with the activation of NGF/Akt and Nrf2/HO-1 pathways and
inhibition
of oxidative stress. This study highlights the potential clinical
application
of curcumin as an oral neuroprotective agent coadministered during
colistin
therapy. Curcumin attenuates copper-induced oxidative stress and
neurotoxicity
Toxicology Reports, March
2020
Curcumin is a hydrophobic polyphenol derived from the rhizome of the
Herb
Curcuma longa belonging to the family Zingiberaceae. Curcumin possesses
antioxidative, anti-inflammatory and anti-depressant-like properties.
Our
findings suggest that Curcumin ameliorated Cu2+-induced neurotoxicity
in D.
melanogaster and as such could be considered an effective therapeutic
agent in
the prevention and treatment of disorders, where oxidative stress is
implicated. Antioxidant, Anti-Inflammatory, and Antiapoptotic Potential
of
Curcumin in Benzo(a)pyrene (BaP)-Induced Lung Injury Journal of
Thoracic
Oncology, March
2020
Curcumin (Cur) has potent anti-inflammatory, antioxidant activity that
defences
cells from oxidative stress and cell death. Thus, curcumin may be an
alternative therapy for improving the outcomes of Benzo(a)pyrene
-induced lung
injury. Curcumin, an Active Constituent of Turmeric Spice: Implication
in the
Prevention of Lung Injury Molecules, March
2020
Curcumin is an active ingredient of Curcuma longa, and it has potent
anti-inflammatory, antioxidant activity that defends cells from
oxidative
stress and cell death. Overall, our findings suggest that curcumin
attenuates
BaP -induced lung injury, probably through inhibiting inflammation,
oxidative
stress and apoptosis in lung epithelial cells, and improving cell
proliferation
and antioxidants level. Ease Joint Pains Caused By Arthritis By Using
This
Spice Extract IB Times, March
2020
Long praised for its anti-inflammatory properties, turmeric is becoming
the
focus of various studies on pain alleviation. The key ingredient of
this
popular Asian spice is curcumin, an active compound found in this
flowering
plant. A review summary of various controlled tests found that a
thousand
milligrams per day of curcumin can reduce osteoarthritic inflammation
and pain.
Its efficacy is comparable to that of non-steroidal anti-inflammatory
drugs or
NSAIDs like ibuprofen and diclofenac. In another study conducted in
2016
, results show that curcumin may help prevent the breakdown of bones in
people
with rheumatoid arthritis. You must choose curcumin extract over the
whole
turmeric, according to the Arthritis Foundation. Curcumin on Improving
Cognitive Function in an Alzheimer’s Disease Neurochemical Research,
March
2020
Berberine and curcumin are extracts from traditional Chinese herbs that
have a
long history of clinical benefits for Alzheimer’s disease. Here,
using a
transgenic Alzheimer’s disease mouse model, we found that the
combined
berberine and curcumin treatment had a much better effect on improving
the
cognitive function of mice than the single-drug treatment, suggesting
synergic
effects of the combined berberine and curcumin treatment. In addition,
we found
that the combined berberine and curcumin treatment had significant
synergic
effects on reducing soluble amyloid-β-peptide(1–42) production.
Furthermore,
the combination treatment also had remarkable synergic effects on
decreasing
inflammatory responses and oxidative stress in both the cortex and
hippocampus
of Alzheimer’s disease mice. We also found that the combination
treatment
performed much better than the single drugs in reducing the APP and
BACE1
levels and increasing AMPKα phosphorylation and cell autophagy, which
might be
the underlying mechanism of the synergic effects. Taken together, the
result of
this study reveal the synergic effects and potential underlying
mechanisms of
the combined berberine and curcumin treatment in improving the symptoms
of
Alzheimer’s disease. Bidirectional interactions between curcumin and
gut
microbiota in transgenic mice with Alzheimer’s disease Applied
Microbiology
and Biotechnology, March
2020
Curcumin administration tended to improve the spatial learning and
memory
abilities and reduce the amyloid plaque burden in the hippocampus of
APP/PS1
mice. On the one hand, curcumin administration altered significantly
the
relative abundances of bacterial taxa such as Bacteroidaceae,
Prevotellaceae,
Lactobacillaceae, and Rikenellaceae at family level, and Prevotella,
Bacteroides,a nd Parabacteroides at genus level, several of which have
been
reported to be key bacterial species associated with Alzheimer’s
disease
development. On the other hand, a total of 8 metabolites of curcumin
biotransformed by gut microbiota of Alzheimer’s disease mice through
reduction, demethoxylation, demethylation and hydroxylation were
identified by
HPLC-Q-TOF/MS, and many of these metabolites have been reported to
exhibit
neuroprotective ability. The findings provided useful clues to
understand the
pharmacology of curcumin and microbiome-targeting therapies for
Alzheimer’s
disease. Best Supplements To Take For Better Brain Health Medical
Daily, March
2020
Turmeric is potent anti-inflammatory, as such it has already shown
potential in
animal studies to reduce or help prevent brain cell damage. Taking
tumeric
helps supplement DHA (docosahexaenoic acid) deficiency, which can make
people
more prone to cognitive disorders. Curcumin, the compound present in
turmeric,
helps in the synthesis of DHA, therefore providing neuroprotection.
Inhibitory
Effect of Curcumin on Artery Restenosis Drug Design, Development and
Therapy,
March
2020
Curcumin is a natural phenolic substance extracted from the rhizome of
the
plant Curcuma longa. Turmeric is commonly present in ordinary diets and
its
traditional use for the treatment of various diseases in China
originates from
several eons ago. Extensive investigations indicate that Cur has
diverse
pharmacological effects, such as antiinflammatory, antioxidant,
antiproliferative and anticarcinogenic, whereas it also protects
against the
development of cerebrovascular diseases. Curcumin provides these
beneficial
effects due to its ability to regulate certain molecular targets,
including
adhesion molecules, growth factors, transcription factors, and factors
involved
in proliferation and apoptosis that are associated with several
different cell
types. Certain studies have shown that Curcumin can inhibit the
proliferation
of VSMCs and prevent stent restenosis following angioplasty. Curcumin
inhibited
the proliferation of smooth muscle cells and neointimal formation and
reduced
the inflammation and oxidative stress indices. Concomitantly, Curcumin
reduced
the phosphorylation of the Raf/MEK/ERK pathway proteins. Conclusion:
Curcumin
could inhibit carotid restenosis following CEA by inhibiting the
activation of
the Raf/MEK/ERK pathway. Boost Your Immunity Today Online, March
2020
The healing benefits of turmeric have been widely documented. Used in
India for
centuries as a spice and medicinal herb, turmeric contains curcumin, a
potent
antioxidant that can help neutralise free radicals, and also natural
anti-inflammatory compounds, which help your body fight pathogens and
repair
damage. Healthy Foods for Your Liver Livestrong, March
2020
Turmeric is having its day in the sun thanks to it being a potent
source of
curcumin, a powerful antioxidant. Curcumin helps to reduce oxidative
stress by
neutralizing the harmful components of oxidative stress, according to
July
2018
research published in Nutrients. Why's this important? Our daily
routines can
really wreak havoc on the liver: Alcohol and medications — even
over-the-counter meds — can cause stress on the liver. And it's not
just any
run of the mill stress; it's oxidative stress. Chronic oxidative stress
could
mean liver damage if it's not addressed. Curcumin also has a
hepatoprotective
effect on the liver, which means it can prevent liver damage thanks to
its
anti-inflammatory properties. Mutual Two-Way Interactions of Curcumin
and Gut
Microbiota The International Journal of Molecular Sciences, February
2020
Curcumin is a natural phenolic component derived from the Curcuma longa
plant
and has been used in India to treat inflammation. Due to its chemical
structure, this molecule can be used in several different areas, such
as food,
textiles and the pharmaceutical industry. Curcumin is widely used as a
spice
and dye in food products with a characteristic yellow color; therefore,
it is
consumed daily. Curcumin is a spice that has recently gained great
interest and
is widely used in Ayurvedic medicine. Curcumin is a promising compound
that is
easily available and easy to use in the diet, and it is also safe and
affordable. Currently available data provide evidence that curcumin has
antitumor activity, induces neuroprotection and neurogenesis, and can
be a new
therapeutic agent in both regenerative medicine and neurodegenerative
diseases,
such as post-ischemic neurodegeneration and Alzheimer’s disease.
Protective
Effects of Curcumin Against Nephrotoxic Agents Cardiovascular &
Hematological
Disorders-Drug Targets, February
2020
Curcumin is the one of the main phenolic ingredients in curcuma species
rhizome. Curcuma species have traditionally been used for the treatment
of
diabetes, cardiovascular, and renal diseases. Studies have shown the
protective
effects of curcumin against nephrotoxic agents such as gallic acid,
glucose,
tartrazine, streptozotocin, lead, cadmium, fluoride, maleate,
malathion,
nicotine, cisplatin, gentamicin, and methotrexate. The current review
indicated
that curcumin may be effective against nephrotoxicity by modulating
oxidative
stress and inflammatory responses. Benefits of Turmeric University of
Utah,
February
2020
Researchers have found that phytochemicals from natural foods, such as
the
curcumin found in turmeric, may be a safe and effective way to help
reduce
inflammation and prevent and treat disease. While acute inflammatory
responses
are beneficial for the body in that they help heal injury, irritation,
or
infection, we know that chronic inflammation can contribute to disease
onset.
There is promising research to support curcumin’s use for the
anti-inflammatory and antioxidant effects on obesity, to reduce
arthritis pain
and swelling, and to aid in complications such as diabetic retinopathy,
nephropathy, and cardiomyopathy. Curcumin Has Anti-Proliferative and
Pro-Apoptotic Effects on Tongue Cancer Drug Design, Development and
Therapy,
February
2020
Curcumin has potential therapeutic effect on treating tongue cancer by
suppressing cell proliferation and migration, as well as promoting
apoptosis
through modulating oxygen-related signaling pathways. Add This Spice To
Your
Diet To Improve Your Chances In Fighting Cancer IB Times, February
2020
Today, scientists reveal that this unassuming plant contains curcumin, a
compound that can kill a tumor and stop the proliferation of cancer
cells.
Researchers conclude turmeric may soon become an effective anti-cancer
drug due
to the antioxidant and anti-inflammatory powers of curcumin. They
reveal that
curcumin has shown great potential in killing cancer cells in
particular types
of cancer. Scientists, however, stopped short in saying they already
found the
cure for cancer. They admitted more research is needed to establish the
cancer-stopping potential of the turmeric compound firmly. For now, it
appears
that curcumin has achieved considerable success in killing cancer cells
and
stop the unabated growth of rogue cells. It also has shown greater
efficacy in
dealing with stomach cancer, breast cancer, skin cancer, and bowel
cancer
cells. Effect of curcumin supplementation on disease severity in
patients with
liver cirrhosis Phytotherapy Research, February
2020
Recent reports indicated that curcumin had beneficial effects in animal
models
of liver injury and cirrhosis. Current study aimed to investigate the
effects
of curcumin supplementation in patients with liver cirrhosis. In this
pilot
study, beneficial effects of curcumin supplementation were observed in
decreasing disease activity scores and severity of cirrhosis in
patients with
cirrhosis. One Spice Can Help You Lose The Nasty Visceral Fat IB Times,
February
2020
According to an Express report, the fat-burning benefits of turmeric
stems from
curcumin. This is the chemical that is found in turmeric and has been
linked to
weight loss. In a study that involved 44 overweight people, the
researchers
found that when they take curcumin even just twice in a month, they
noticed how
effective it was in aiding the process of weight loss. It was
attributed to a
decrease in belly fat. It also helped reduce weight. Aside from the
study
involving the 44 individuals, a separate study on mice showed that mice
that
were given curcumin for 12 weeks showed a reduction in body weight.
They found
out that it blocked the synthesis of fat. Combining the results of both
studies, it would show how effective curcumin is in weight loss.
Superfoods &
cancer risks Deccan Herald, February
2020
Curcumin is an antioxidant found in turmeric. It helps the body to
fight
against HPV and protect against cervical cancer by slowing down or
limiting the
activity of the virus. The In-Vitro Effect of Curcumin and Arsenic
Trioxide on
The Level Of NF-kB and Induction of Apoptosis in B16 Cell Lines Karbala
Journal
of Medicine, February
2020
Curcumin is a natural product that had been utilized for a variety of
maladies
like rheumatic, cardiac, neurological and numerous other disorders.
Curcumin
had very potent concentration dependent anti-cancer effects against B16
MM cell
line. CBD and Turmeric – Why This Is A Great Combination
prospercbdnews.com,
February
2020
Turmeric, the spice also known as Indian saffron, comes from the Ginger
family.
It has several properties that overlap those of cannabidiol which is
what makes
it a wonderful addition to CBD products. Turmeric has been used in
Ayurvedic
practices for centuries. It has a therapeutic nature and several
medicinal
applications. Being a strong anti-inflammatory agent, turmeric improves
brain,
heart, and joint health. The curcumin in turmeric is where its strength
lies.
Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative
Stress by
Activating the Nrf2 Pathway Drug Design, Development and Therapy,
February
2020
Curcumin attenuates oxaliplatin-induced liver injury and oxidative
stress by
activating the Nrf2 pathway, which suggests that CUR may be potentially
used in
the prevention and treatment of OXA-induced liver injury. Adding
Curcumin to
Mesalamine May Benefit Patients With Ulcerative Colitis empr.com,
February
2020
Adjunctive therapy with curcumin was found to provide a greater
clinical
benefit than placebo in patients with ulcerative colitis (UC) being
treated
with mesalamine, according to the findings of a recently published
systematic
review and meta-analysis. The study authors reported that the odds of
clinical
response were approximately threefold better for patients who received
the
combination of mesalamine plus curcumin vs placebo.“This response was
statistically significant, albeit with heterogeneity, probably due to
the
different severity scoring indices, curcumin dosages and routes of drug
delivery used,†the authors stated. They added, “Given the minimal
adverse
events, we recommend that curcumin be considered as an adjunct to
mesalamine in
the treatment of UC." Effect of curcumin on expression of μ opioid
receptors
Civilica.com, February
2020
Recent studies have shown that curcumin, the active ingredient of
turmeric,
reduces the symptoms of withdrawal syndrome in morphinedependent mice.
Treatment with curcumin resulted in a significant and dose-dependent
attenuation of withdrawal syndrome along with a decrease in the
expression of
spinal μ opioid receptors in morphine-dependent rats. The maximum
effect was
obtained from curcumin at the dosage of 10 mg/kg. The results of this
study
indicate that curcumin is capable of attenuating morphine dependence in
rats
through decreasing the expression of spinal opioid μ receptors.
Curcumin
supplementation improves heat-stress-induced cardiac injury The Journal
of
Nutritional Biochemistry, February
2020
Curcumin may increase animal survival and lifespan under heat stress.
Our
results indicated that curcumin supplementation could alleviate
HS-induced
physiological disorders and the increasing of cTn-I and Ang II. The
expression
of AT1 gene in HT group was significantly higher than that of curcumin
groups,
indicating the cardioprotective effects of curcumin. Moreover, the
levels of
GRP78 and CHOP proteins in the HT group were significantly higher than
those of
curcumin groups, indicating that curcumin supplementation reversed the
endoplasmic reticulum HS-mediated apoptosis. In summary, curcumin
supplementation alleviates physiological stress and cardiac damage
caused by
HS. Modulation of Exercise-Induced Muscle Damage, Inflammation, and
Oxidative
Markers by Curcumin Supplementation in a Physically Active Population
Nutrients, February
2020
Curcumin, a natural polyphenol extracted from turmeric, has been shown
to have
mainly antioxidant and also anti-inflammatory properties. This effect
of
curcumin could improve Exercise-Induced Muscle Damage and exercise
performance.
The use of curcumin reduces the subjective perception of the intensity
of
muscle pain; reduces muscle damage through the decrease of creatine
kinase
(CK); increases muscle performance; has an anti-inflammatory effect by
modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and
IL-8; and
may have a slight antioxidant effect. In summary, the administration of
curcumin at a dose between 150–1500 mg/day before and during
exercise, and up
until 72 hours post-exercise, improved performance by reducing EIMD and
modulating the inflammation caused by physical activity. In addition,
humans
appear to be able to tolerate high doses of curcumin without
significant
side-effects. Curcumin and Cancer Nutrients, January
2020
Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained
attention from scientists worldwide for its biological activities
(e.g.,
antioxidant, anti-inflammatory, antimicrobial, antiviral), among which
its
anticancer potential has been the most described and still remains
under
investigation. The present review focuses on the cell signaling
pathways
involved in cancer development and proliferation, and which are
targeted by
curcumin. Curcumin has been reported to modulate growth factors,
enzymes,
transcription factors, kinase, inflammatory cytokines, and proapoptotic
(by
upregulation) and antiapoptotic (by downregulation) proteins. This
polyphenol
compound, alone or combined with other agents, could represent an
effective
drug for cancer therapy. How turmeric could offer hope in the fight
against
CANCER: Scientists say compound curcumin found in the popular spice has
tumour-killing potential DailyMail, January
2020
A compound found in turmeric could unlock new treatments in the battle
against
cancer, a scientific review has suggested. Researchers say the
anti-inflammatory and antioxidant powers of curcumin mean it could halt
the
development of tumours. They analysed almost 5,000 studies and found it
blocked
the growth of eight types of cancers, under laboratory settings.
Results showed
it was effective at treating breast, lung, blood, stomach, pancreatic,
bowel,
bone marrow and prostate cancer. Curcumin, a compound found in
turmeric, could
‘halt tumour development’, major study says College Of Medicine,
January
2020
New scientific research has found that a common compound found in the
spice
turmeric could stop cancerous tumours from growing further. A study,
carried
out by academics at Temple University in Philadelphia, and published in
the
Nutrients journal, found the antioxidant and anti-inflammatory
properties of
curcumin halted the development of eight different types of cancer.
Analysing
nearly 5,000 studies, researchers said the compound – which gives
turmeric
its bright orange colour – was effective at treating pancreatic,
bowel, bone
marrow, prostate, breast, lung, blood and stomach cancer. Results
showed
nutrients that the tumours needed to thrive were halted by curcumin,
which also
blocked harmful proteins produced by cancer cells. The study’s lead
scientists concluded that the compound could ‘represent an effective
drug for
cancer treatment, alone or combined with other agents’. Dr Antonio
Giordano,
a pathologist at Temple University, lead a team who looked at almost
13,000
studies carried out on curcumin since 1924, focusing specifically on
4,738
studies that looked at how the compound affected cancer. The study’s
authors
said: “The search for new effective drugs able to combat cancer
diseases
still represents a challenge for many scientists. “Natural organisms
(e.g.,
plants, bacteria, fungi) provide many active molecules with a potential
application in medicine for the management of many diseases. “As
reported in
the present review, curcumin exhibits anticancer ability by targeting
different
cell signaling pathways including growth factors, [the transport of
nutrients
and killing healthy cells].†Curcumin, as a potent anticancer agent
for the
treatment of breast cancer First International Conference on Management
of
Agricultural Sciences, January
2020
Curcumin, an orange-yellow component of turmeric or curry powder, is a
highly
pleiotropic molecule which shows promising effects on various
pro-inflammatory
diseases, inflammatory conditions, hepatic conditions, metabolic
syndromes,
degenerative eye conditions, etc. Over the past decades, numerous
studies have
demonstrated that curcumin has several anticancer effects in various
types of
cancers, including breast cancer.Materials and Methods: In the present
review,
we aimed to investigate the role of curcumin on the treatment of breast
cancer.
For this purpose, we searched scientific databases including Scopus,
Pubmed,
Clinical key, etc.Results: The growth inhibitory effect of curcumin has
been
studied on different models of breast cancer. Our findings showed that
curcumin
inhibits the growth of breast cancer cells by suppressing cell
proliferation
and metastasis and inducing cell death without no toxicity to normal
cells.
Importantly, curcumin treatment increases the effectiveness of
chemotherapy and
decreases the number of cancer stem cells. There are studies showing
that the
ability of curcumin to reduce chemoresistance tumor cells, to inhibit
the
reattachment of BCSCs, and to prevent the migratory ability of Breast
cancer
stem cells.Conclusion: Based on our findings, it is recommended that
the use of
curcumin can have beneficial effects on the survival rates of patients
with
breast cancer. Curcumin compound in turmeric could help beat cancer The
Saxon,
January
2020
Academics from Temple University in Philadelphia say curcumin stops
nutrients
from being transported to tumours. It also prevents the death of
healthy cells
by blocking cancer cells from releasing harmful proteins. The academics
concluded curcumin – the pigment in turmeric that gives it its colour
–
could ‘represent an effective drug for cancer treatment, alone or
combined
with other agents’. 7 Fitness-Supporting Supplements That Get The RDN
Stamp
Of Approval MindBodyGreen, January
2020
As the active ingredient in turmeric root, curcumin is a powerful
antioxidant
and anti-inflammatory that has been shown to help reduce stress from
physical
activity. Think of this potent yellow spice as an herbal aid in
recovery:
"Studies show curcumin may relieve joint discomfort associated with
exercise or
overuse," says Blakely, "which can help you get back in the gym for
your next
workout faster." Curcumin, as a pleiotropic agent, improves
doxorubicin-induced
nephrotic syndrome in rats. Journal of Ethnopharmacology, January
2020
Curcumin, a phenolic compound extracted from the rhizome of turmeric
(Curcuma
longa L.), has been reported to have broad biological functions
including
potent antioxidant and renoprotective effects. It has been reported
that
Curcumin has a certain protective effect on the kidney. The
consequences of
this study revealed that curcumin activated Nrf2, inhibited NF-κB
pathway and
up-regulated podocin in DOX-induced podocyte. Further research results
showed
that curcumin can considerably alleviate proteinuria and improve
hypoalbuminemia in NS rats, and lower blood lipid levels to alleviate
hyperlipidemia in NS rats, indicating that curcumin has significant
therapeutic
effects on rat NS. Further observation by electron microscopy and
detection
showed that curcumin can improve renal function and podocyte injury,
which may
be related to the repairment of mRNA expression and podocin protein.
Interestingly, the results of the blood rheology test showed that
curcumin can
effectively reduce whole blood viscosity (WBV) and plasma viscosity
(PV), and
reduce hematocrit (Hct). In addition, the oxidative stress state of
kidney in
NS rats was considerably reversed by curcumin, which may be achieved by
activating Nrf2 and increasing the expression of antioxidant enzymes
HO-1,
NQO-1. We also found that NF-κB pathway is activated in the kidney of
NS rats,
and curcumin can inhibit the activation of NF-κB by down-regulating
the
expression of NF-κB p65, reducing the level of p-IκBα and
up-regulating the
expression of IκBα. These findings suggest that curcumin, as a
multifunctional agent, exerts a protective effect on DOX-induced
nephrotic
syndrome in rats, which provides a pharmacological basis for the
further
development of curcumin and also provides a basis for the advantages of
multi-targeted drugs in the processing of NS. Herbs That Help Alleviate
Symptoms Of Chronic Obstructive Pulmonary Disease ibtimes, January
2020
Turmeric contains a compound called curcumin which helps reduce airway
inflammations. Curcumin is a very powerful antioxidant that helps
combat
oxidative stress underlying COPD by blocking inflammation at a
molecular level.
A
2009
study has reported that curcumin inhibits COPD-like airway inflammation
and the
progression of lung cancer. The findings of the study demonstrated that
curcumin can be used to inhibit the progression of lung cancer in
high-risk
COPD patients. Several other pieces of research have pointed to
curcumin’s
antiviral, anti-inflammatory and antioxidant effects. This herb’s
potential
ability to fight or prevent cancer is intriguing. Nutraceutical
Activities of
Turmeric (Curcuma longa) and its Bioactive Constituent Curcumin
Department of
Biochemistry, CSIR, December
2019
In the past couple of decades, many health beneficial physiological
effects of
turmeric or its constituent ─ curcumin have been documented in
experimental
and/or clinical studies which suggest that consumption of this spice
offers
benefits beyond sensory attributes. Turmeric and curcumin have been
shown to
exert preventive and ameliorative influence on diabetes, cardiovascular
disease, inflammatory disorders, and cancer. The antioxidant property
of
turmeric/ curcumin explains its diverse pharmacological potential.
Curcumin
effectively reduces lipid peroxidation through its antioxidant
influence.
Turmeric is traditionally employed as an anti-inflammatory drug.
Experimental
research indicates that curcumin suppresses both tumour initiation and
promotion. The anticarcinogenic effect of curcumin is mediated through
inhibition of the transcription factor NFkB and proinflammatory
pathways.
Curcumin induces apoptosis, and suppresses tumour proliferation and
angiogenesis. The anticancer potential of curcumin is also evidenced in
clinical studies. "Curcumin supplementation modulated the gut
microbiota
composition and ameliorated intestinal dysbiosis by decreasing the
ratio of
Firmicutes/Bacteroidetes and endotoxin-producing Desulfovibrio bacteria
and
increasing the abundance of Akkermansia population and SCFA-producing
bacteria,
such as Bacteroides, Parabacteroides, Alistipes and Alloprevotella,
along with
increases in caecal and colonic SCFA concentrations. These dominant
bacterial
genera altered by curcumin showed strong correlations with the
obesity-related
metabolic parameters in HFD-fed mice. In conclusion, our data suggest
that
curcumin alleviated metabolic features of hepatic steatosis and insulin
resistance in HFD-fed obese mice, which might be associated with the
modulation
of gut microbiota composition and metabolites." - Curcumin alleviates
high-fat
diet-induced hepatic steatosis and obesity in association with
modulation of
gut microbiota in mice | May
2021
"After oral administration, curcumin is distributed in the intestines,
and then
curcumin exerts its effects on the gut microbiota (such as microbial
richness,
diversity, and composition). Curcumin administration exerts significant
effects
on gut microbiota family such as Bacteroidaceae, Rikenellaceae, and
Prevotellaceae. Moreover, curcumin significantly promoted gut
microbiota,
including Anaerotruncus, Exiguobacterium, Helicobacter, Papillibacter,
Pseudomonas, Serratia, and Shewanella. Curcumin also ameliorates the
intestinal
barrier function (by modulating intracellular signaling and the
organization of
tight junctions) in metabolic diseases, as indicated by a reduced rate
of
bacterial translocation to the blood, liver, kidneys, and spleen. A
study
showed that administration of curcumin significantly reduced the
Western-diet-induced blood lipopolysaccharide and ameliorated the
intestinal
barrier. Thus, it can be concluded that curcumin prevents metabolic
diseases
through a mechanism involved in the regulation of the intestinal
barrier. Many
studies suggest that curcumin can actively hinder intestinal
inflammation by
modulating the homeostasis of the gut-brain axis, and could also
exhibit
neuroprotective beneficial. Further, curcumin treatment decreases the
microbial
abundance of cancer-related species like Prevotella, Coriobacterales,
and
Ruminococcus. These help to exhibit antioxidative and anticancer
properties." -
Curcumin and Metabolic Diseases: The Role of Gut Microbiota, Nutrients |
January
2021
"The remarkable effects of curcumin on isolated gut microbiota may
explain the
wide range of its beneficial effects. Several studies showed that
curcumin has
positive effects on several diseases by changing the distribution of
some gut
microbiota. This may be an important mechanism underlying therapeutic
benefits
of curcumin." - Does Curcumin Have a Role in the Interaction between
Gut
Microbiota and Schistosoma mansoni in Mice, Pathogens | September
2020
"Curcumin could exert direct regulative effects primarily in the
gastrointestinal tract, where high concentrations of this polyphenol
have been
detected after oral administration. Consequently, it might be
hypothesized that
curcumin directly exerts its regulatory effects on the gut microbiota,
thus
explaining the paradox between its low systemic bioavailability and its
wide
pharmacological activities. Interestingly, curcumin and its metabolites
have
been shown to influence the microbiota. It is worth noting that from
the
interaction between curcumin and microbiota two different phenomena
arise: the
regulation of intestinal microflora by curcumin and the
biotransformation of
curcumin by gut microbiota, both of them potentially crucial for
curcumin
activity." - Interaction between Gut Microbiota and Curcumin: A New Key
of
Understanding for the Health Effects of Curcumin, Nutrients | July
2020
"Curcumin, an herbal naturally occurring polyphenol, has recently been
proposed
for the treatment of neurodegenerative, neurological and cancer
diseases due to
its pleiotropic effect. Recent studies indicated that gut microflora
may be a
new potential therapeutic target. The new working hypothesis that could
explain
the curative role of curcumin, despite its limited availability, is
that
curcumin acts indirectly on the brain, affecting the
“gut–brain–microflora axisâ€, a complex two-way system in which
the gut
microbiome and its composition, are factors that preserve and determine
brain
health. It is therefore suspected that curcumin and its metabolites
have a
direct regulatory effect on gut microflora and vice versa, which may
explain
the paradox between curcumin’s poor bioavailability and its commonly
reported
therapeutic effects. Curcumin and its metabolites can have health
benefits by
eliminating intestinal microflora dysbiosis. In addition, curcumin
undergoes
enzymatic modifications by bacteria, forming pharmacologically more
active
metabolites than their parent, curcumin. Curcumin is present in high
concentrations in the gastrointestinal tract after oral administration.
Given
the pathogenic links between intestinal microflora and many diseases,
current
findings could help us interpret the therapeutic advantage of
curcumin." -
Mutual Two-Way Interactions of Curcumin and Gut Microbiota, The
International
Journal of Molecular Sciences | February
2020
"The present study demonstrated that curcumin could interact with gut
microbiota in two directions. On one hand, curcumin exerted direct
influence on
the gut microbiota of curcumin, and it could normalize especially the
relative
abundance of several key bacterial taxa involved in Alzheimer’s
disease
development. On the other hand, gut microbiota could biotransform
curcumin into
a series of metabolites, which had been reported to possess
neuroprotective
effects. The findings not only interpreted the paradox between the
pharmacological effect of curcumin and its poor bioavailability, but
also
implied that metabolites of curcumin biotansformed by gut microbiota
might act
as an important source to screen biologically active compounds to
combat
Alzheimer’s disease. Further, the interaction between curcumin and
gut
microbiota provided clues to elucidate the pharmacology of natural
polyphenolic
compounds, which was worthy of further study" - Bidirectional
interactions
between curcumin and gut microbiota, Applied Microbiology and
Biotechnology |
February
2020
"Curcumin represents one of the most studied herbal remedies,
responsible for
different pharmacological activities. The paradox of poor
bioavailability of
curcumin and the wide range of health effects of curcumin can be
explained by
considering the reciprocal influence existing between curcumin and gut
microbiota. Curcumin in the gut favors the growth of beneficial
bacteria
strains such as Bifidobacteria and Lactobacilli, with reduction of
pathogenic
strains. In addition, curcumin treatment has been found to decrease the
microbial richness and diversity, with a specific reduction of species
found as
cancer-related. Several studies reported that curcumin actively reduces
intestinal inflammation by modulating different molecular pathways.
Thus, it is
possible that curcumin, by modulating the homeostasis of the
gut–brain axis,
could also determine neuroprotective beneficial effects. To address its
pharmacological and therapeutic advantages, it is fundamental to
consider
curcumin interplay with gut microbiota that might pave the way to fill
the gap
between the low bioavailability and the wide health effects. Curcumin
can
influence gut microbiota composition, allowing the growth of strains
needed to
maintain correct host physiologic functions. This is the case of
neurodegenerative diseases in which often a gut dysbiosis precedes the
onset of
the clinical signs. The results summarized in the review suggest that
curcumin
alone can exert a neuroprotective function by affecting different
neuropathological pathways."- Curcumin, Gut Microbiota, and
Neuroprotection,
Nutrients | December
2019
"Bioavailability of curcumin is not an issue. The therapeutic efficacy
of
curcumin as evident from numerous clinical trials overpowers the
hindrance of
low bioavailability. Over 200 clinical studies with curcumin have
demonstrated
the pronounced protective role of this compound against cardiovascular
diseases, inflammatory diseases, metabolic diseases, neurological
diseases,
skin diseases, liver diseases, various types of cancer, etc. The
therapeutic
potential of curcumin, as demonstrated by clinical trials has
overpowered the
myth that poor bioavailability of curcumin poses a problem. Low
curcumin
bioavailability in certain studies has been addressed by using higher
concentrations of curcumin within nontoxic limits. Hence,
bioavailability is
not a problem in the curcumin-mediated treatment of chronic diseases.
Therefore, this golden nutraceutical presents a safe, low-cost and
effective
treatment modality for different chronic diseases." - Is curcumin
bioavailability a problem in humans: lessons from clinical trials, Drug
Metabolism Toxicology | September
2019
"In recent years, an exponentially increasing number of studies has
indicated
that the alterations in the intestinal microbiota are linked with many
metabolic diseases, including obesity, diabetes, and chronic liver
disease, and
the intestinal microbiota is proposed to be a novel potential
therapeutic
target for these microbiota-associated diseases. Although curcumin has
poor
systemic bioavailability, after oral administration it is expected to
be
present in high concentrations in the gastrointestinal tract. Thus, it
is
rational to infer that curcumin may exert direct regulative effects on
the gut
microbiota. This may be an important mechanism underlying its
therapeutic
benefits and could explain the paradox between curcumin’s poor
systemic
bioavailability and its widely reported pharmacological activities." -
Regulative effects of curcumin spice administration on gut microbiota
and its
pharmacological implications, Food & Nutrition Research | August
2019
"The bioavailability of the parent curcumin compound is low, but oral
administration of curcumin can still deliver detectable levels of
curcumin
glucuronide metabolite. Despite the absence of the parent curcumin in
the
blood/plasma, the antioxidant and epigenetic modulatory effects of
curcumin
glucuronide can explain the potential overall health beneficial effect
of this
herbal medicinal product. Thus, it is reasonable to believe that most
of the
curcumin effects in vivo may be due to local and direct effects rather
than
systemic effects of this turmeric compound after absorption. This
suggests
there may be potential health benefits of taking curcumin and
challenges
negative perceptions on the lack of health benefit or efficacy of
taking oral
curcumin. In conclusion, the results of our current study are highly
relevant
to the over-the-counter use of botanical curcumin in a real-world
scenario." -
Pharmacokinetics, pharmacodynamics and PKPD modeling of curcumin in
regulating
antioxidant and epigenetic gene expression in human healthy volunteers,
Molecular Pharmaceutics | March
2019
"Effects of Curcumin on Gut Microbiota | Given the low systemic
bioavailability
of curcumin and its pharmacological therapeutic uses, curcumin might
provide
benefit by acting on gut microbiota. This impact on the gut microbiota
seems to
be reasonable and attractable areas of study as no absorption of the
parent
compound is necessary. It is suspected that curcumin could exert direct
regulative effects on the gut microbiota which could explain the
paradox
between curcumin's poor systemic bioavailability and its widely
reported
pharmacological effects. There is some indication that curcumin may act
as
promoting factors of growth, proliferation, or survival for beneficial
members
of the gut microbiota, and is able to modulate gut microbial
composition (i.e.,
biodiversity). It is suggested that healthy ageing correlates with
microbiome
diversity. The administration of curcumin significantly shifted the
ratio
between beneficial and pathogenic microbiota by increasing the
abundance of
bifidobacteria, lactobacilli, and butyrate-producing bacteria and
reducing the
loads of Prevotellaceae, Coriobacterales, enterobacteria, and
enterococci.
Curcumin, through impacts on the microbiota, might positively influence
certain
organismal functions. By modulating the microbiome, curcumin may reduce
some
adverse consequences of ageing, and the impact of curcumin on the
microbiome
seems to be very promising in the context of the modulation of the
ageing
process. These alterations in gut microbiota could also explain the
immune
modulation and antihyperlipidemia efficacy of curcumin aside of its
anti-inflammatory and anticolonotropic carcinogenicity activity.
Effects of Gut
Microbiota on Curcumin | The composition of gut microbiota had a
profound
influence on the biotransformation of curcumin in the colon by various
processes mainly by reduction followed by conjugation, which might have
a
significant impact on the health effects of dietary curcumin,
especially in the
GI. Data suggests that intestinal bacteria produce a high amount of
β-glucuronidase that can elevate the level of free compounds.
Microbiota can
be responsible for drug metabolism and, by their ability to metabolize
curcumin, can regulate its bioavailability." - Gut Microbiota as a
Prospective
Therapeutic Target for Curcumin: A Review of Mutual Influence, Journal
of
Nutrition and Metabolism | December
2018
"Curcumin has anti-inflammatory, anti-oxidant and anti-proliferative
properties
established largely by in vitro studies. Accordingly, oral
administration of
curcumin beneficially modulates many diseases including diabetes,
fatty-liver
disease, atherosclerosis, arthritis, cancer and neurological disorders
such as
depression, Alzheimer's or Parkinson's disease. We established
curcumin-mediated decrease in the release of gut bacteria-derived
lipopolysaccharide (LPS) into circulation by maintaining the integrity
of the
intestinal barrier function as the mechanism underlying the attenuation
of
metabolic diseases (diabetes, atherosclerosis, kidney disease) by
curcumin
supplementation precluding the need for curcumin absorption. In view of
the
causative role of circulating LPS and resulting chronic inflammation in
the
development of diseases listed above, this review summarizes the
mechanism by
which curcumin affects the several layers of the intestinal barrier
and,
despite negligible absorption, can beneficially modulate these
diseases." -
Curcumin-mediated regulation of intestinal barrier function: The
mechanism
underlying its beneficial effects, Tissue Barriers | February
2018
"Curcumin was a potent anti-helicobacter pylori agent in vivo and in
vitro.
Curcumin could partially reverse changes in the diversity of the gut
microbiota
and could lower the increasing abundance of the genera Anaerotruncus
and
Helicobacter in the gut of model rats." - Effect of Curcumin on the
Diversity
of Gut Microbiota in Ovariectomized Rats, Nutrients | October
2017
"Studies provide evidence that despite low bioavailability, oral
curcumin
likely mediates its anti-inflammatory (and inflammation-dependent
downstream
effects) by its local action in the gut. Studies from our laboratory
demonstrated the potent effects of oral supplementation with curcumin
on the
development of glucose intolerance and atherosclerosis. Furthermore,
curcumin
supplementation attenuated increase in plasma lipopolysaccharide levels
by not
only increasing the activity of intestinal alkaline phosphatase that
detoxifies
lipopolysaccharide in the gut lumen but also by improving intestinal
barrier
function. The data presented herein establishes the intracellular
mechanisms by
which curcumin improves the intestinal barrier. Apical or luminal
exposure to
curcumin might underlie its observed effects on improvement of
intestinal
barrier function by oral administration. The major site of action of
curcumin
is the intestinal epithelial cells and the intestinal barrier, and by
reducing
intestinal barrier dysfunction, curcumin modulates chronic inflammatory
diseases despite poor bioavailability. Reduced intracellular IL-1β
signaling
and subsequent reduction in disruption of tight junctions represent the
mechanisms underlying the beneficial effects of oral curcumin, despite
its poor
bioavailability. The causal relationship between curcumin exposure of
intestinal epithelial cells and inflammatory bowel diseases is
straightforward
and is not affected by the issue of poor bioavailability, and oral
curcumin is
currently being considered as a therapeutic agent for inflammatory
bowel
disease. Curcumin is expected to not only reduce local inflammation in
the gut,
but by altering intestinal barrier function it will also reduce
systemic
inflammation triggered by the release of lipopolysaccharide into
circulation."
- Curcumin improves intestinal barrier function: modulation of
intracellular
signaling, and organization of tight junctions, American Journal of
Physiology
Cell Physiology | April
2017
"Metabolites of curcumin are present in high concentrations in the
circulation
after curcumin consumption. These curcumin metabolites may be
responsible for
the anti-inflammatory and antioxidant activities that reduce the
symptoms of
metabolic diseases including osteoarthritis. Curcumin is detectable in
the
circulation as the forms of glucuronide and sulfate conjugates in the
patients
with oral consumption of 8 g/day curcumin for more than 2 months.
Thus,
curcumin itself can be a therapeutic agent for relieving arthritis." -
Efficacy
of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint
Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical
Trials,
Journal of Medicinal Food |August
2016
"Despite a wide range of pharmacological activities of curcumin
reported in the
past decades, a paradox remains regarding the pharmacology of curcumin:
how
curcumin is able to manifest remarkable biological effects under the
condition
of poor systemic bioavailability. Our novel experimental and
theoretical
findings suggested that the degradation products should play important
roles in
executing the biological and pharmacological activities of curcumin.
The
degradation products of curcumin are actually the main bioactive
molecules in
executing the biological activities of curcumin.Our finding not only
provides a
plausible explanation for the seemingly contradictory observations
regarding
biological activities of curcumin, it is also highly significant for
the
therapeutic application of this natural product against various human
diseases." - How does curcumin work with poor bioavailability? Clues
from
experimental and theoretical studies, Scientific Reports | February
2016
"The beneficial effect of curcumin on tumorigenesis was associated with
the
maintenance of a more diverse colonic microbial ecology.These
chemopreventive
effects appeared unrelated to the reduction of inflammation, but rather
to the
normalizing effects of curcumin on colonic microbial ecology, thus
suggesting
that curcumin functions as an effective agent for restoring healthy gut
homeostasis and microbial-host relationship. We determined that dietary
curcumin maintained high microbial diversity, associated with the
expansion of
Lactobacillales (represented mainly by genus Lactobacillus). Curcumin
contributes to chemoprevention via expansion of the native Lactobacilli
in the
context of overall increase of colonic microbiome richness. Curcumin
has been
observed to inhibit bacterial motility and cytotoxicity of Vibrio
vulnificus,
to arrest Helicobacter pylori growth during infections, as well as
inhibit
biofilm formation in Pseudomonas aeruginosa. This suggests that the
protective
effect of 0.5% curcumin diet shifts the microbial composition to be
more
stationary, which may contribute to a decrease in microbial
invasiveness and a
decrease in overall disease severity. We demonstrated efficacy of
curcumin on
inflammation associated colorectal cancer and normalizing effects of
colonic
microbial ecology. Curcumin may represent a promising approach to
chemoprevention in IBD. " - The Role of Curcumin in Modulating Colonic
Microbiota During Colitis and Colon Cancer Prevention, Inflammatory
Bowel
Diseases | November
2015
"Curcumin treatment exerted a significant anti-inflammatory effect in
H.
pylori-infected mucosa, pointing to the promising role of a nutritional
approach in the prevention of H. pylori induced deleterious
inflammation.
Curcumin may be a potential agent for controlling inflammation
associated with
H. pylori infection. The aim of the present study is to evaluate the
anti-inflammatory effect of curcumin using the experimental model of H.
pylori
chronic infection. Curcumin was effective in reducing the inflammation
of the
gastric mucosa of H. pylori-infected mice, which was confirmed at the
molecular
level. At this level the magnitude of the difference in the expression
of the
inflammatory mediators’ encoding genes between the infected
curcumin-treated
mice and the infected but non-treated ones strongly supports the
powerful
anti-inflammatory properties of curcumin. Curcumin acted two ways
during
protection against H. pylori infection, i.e. by eradicating H. pylori
as well
as potentially targeting key molecules involved in the H.
pylori-induced
gastric diseases. This is one of the few studies using both
histological and
molecular approaches, showing the important anti-inflammatory role of
curcumin
in the context of chronic H. pylori infection. Taking into account the
extensive consumption of polyphenols in the human diet (curcumin and
others),
our data points to the promising role of a nutritional approach in the
control
of H. pylori induced deleterious inflammation." - Curcumin Inhibits
Gastric
Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model,
Nutrients | January
2015
"Curcumin exerts potent effects in reducing metabolic diseases such as
diabetes
and atherosclerosis by modulating the intestinal barrier function,
precluding
the need for effective absorption and systemic bioavailability.The
significant
reduction in glucose intolerance as well as atherosclerosis by oral
curcumin
demonstrates the importance of targeted improvement in intestinal
barrier
function as a potential therapeutic strategy. This represents a change
in the
existing paradigm and places the focus on improving intestinal barrier
function
rather than direct modulation of gut bacteria itself. In conclusion,
the data
presented here provide direct evidence for the role of Western
diet-induced
disruption of intestinal barrier function in the development of
metabolic
diseases such as diabetes and atherosclerosis. Furthermore, these
studies also
identify curcumin as an agent effective in restoring the intestinal
barrier
function by modulating multiple components of this barrier including
IAP and
paracellular permeability. Future studies will examine the effects of
curcumin
on other components of the intestinal barrier to further advance our
current
understanding and to develop curcumin as a dietary supplement to
attenuate
multiple inflammation-linked diseases." - Oral Supplementation with
Curcumin
Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance
| Role
of Intestinal Permeability and Macrophage Activation, PLoS One |
September
2014
"Our experiments show that curcumin supplementation can suppress H.
pylori-induced gastric inflammation, as indicated by decreased NF-κB
p65
expression in gastric epithelial cells and decreased macromolecular
leakage in
the gastric microcirculation. Curcumin decreased these parameters,
indicating
that curcumin could decrease gastric inflammation. Curcumin
supplementation may
exert its anti-inflammatory effect by reducing macromolecular leakage
through
the suppression of NF-κB p65 expression in gastric epithelial cells.
Hence,
curcumin might be a novel therapeutic strategy against gastric
inflammation." -
Curcumin suppresses gastric NF-κB activation and macromolecular
leakage in
Helicobacter pylori-infected rats, World Journal of Gastroenterology |
August
2010
"Curcumin is biotransformed in the intestinal tract of humans. Curcumin
is a
large lipophilic molecule that undergoes extensive gastrointestinal and
hepatic
metabolism after oral dosing. Phase I metabolism is through a reduction
reaction forming tetra-hydrocurcumin, hexahydrocurcumin, and
hexa-hydrocurcuminol. Phase II metabolism consists of glucouronidation
and
sulfation by O-conjugation to form curcumin glucuronide and curcumin
sulfate.
Gut metabolism contributes substantially to the overall metabolite
yield
generated from curcumin in vivo. The pharmacological implications of
the
intestinal metabolism of curcumin should be taken into account in the
design of
future chemoprevention trials of this dietary constituent." -
Metabolism of the
Cancer Chemopreventive Agent Curcumin in Human and Rat Intestine,
Cancer
Epidemiology, Biomarkers & Prevention | January
2002
n most studies Curcumin 95% has been delivered orally whether the
subject is
human or animals. This orally delivered Curcumin 95% extract showed
antioxidant, anti-inflammatory, antidiabetic, and anticancer beneficial
effects. Oral curcumin efficacy in vivo has been shown in models for
many
conditions with oxidative damage and inflammation, including many types
of
cancer, diabetes, atherosclerosis, arthritis, stroke, peripheral
neuropathy,
inflammatory bowel, and brain trauma. Curcumin is fat-soluble, so when
combined
with healthy fats and oils, the body can absorb it better because
curcumin is
directly absorbed into the bloodstream through the lymphatic system
thereby in
part bypassing the liver. A traditional method of dissolving curcumin
in fat is
likely an effective method to improve absorption. You can also ensure
you are
absorbing the maximum amount by consuming curcumin with fats from meat,
fish,
dairy, olive oil, coconut oil and others. "In vitro and in vivo studies
have
confirmed the activity of curcumin in biological system by either
detecting
curcumin or its bio-transformed metabolites in plasma, peripheral
organs and
brain." - bioRxiv "Clinical trials have shown that orally delivered
curcumin
inhibited inflammatory molecules." - AAPS Journal "Levels of curcumin
and its
metabolites in plasma, urine, and feces were analyzed by high-pressure
liquid
chromatography and mass spectrometry. A daily dose of 3.6g curcumin
engendered
62% and 57% decreases in inducible PGE2 production in blood samples
taken 1
hour after dose on days 1 and 29, respectively, of treatment compared
with
levels observed immediately predose (P < 0.05). A daily oral dose of
3.6g of
curcumin is advocated for Phase II evaluation in the prevention or
treatment of
cancers outside the gastrointestinal tract. PGE2 production in blood
and target
tissue may indicate biological activity. Levels of curcumin and its
metabolites
in the urine can be used to assess general compliance." - Clinical
Cancer
Research "Oral curcumin, 6.0 g daily during radiotherapy, reduced the
severity
of radiation dermatitis in breast cancer patients." - Radiation
Research
"Curcumin mixed with the diet achieves drug levels in the colon and
liver
sufficient to explain the pharmacological activities observed and
suggest that
this mode of administration may be preferable for the chemoprevention
of colon
cancer. The colon mucosal level of curcumin after 14 days feeding
observed in
this study, 1.8 μmol/g, is more than 300-fold higher than the minimal
concentration shown to be active in vitro. This result demonstrates
that
dietary administration of curcumin can produce pharmacologically
relevant drug
concentrations in colon mucosa. Our results therefore intimate that
dietary
curcumin at doses considerably lower than those used here might yield
pharmacologically efficacious levels in the colon mucosa and perhaps
also in
the liver. The M1G-lowering effect of curcumin provides a tentative
rationale
for the regular use of dietary curcumin in the protection of the colon
mucosa
against oxidative damage, perhaps in premalignant conditions such as
ulcerative
colitis. Dietary administration of curcumin to rats produces
pharmacologically
active levels of unmetabolized curcumin in the colon mucosa and liver,
capable
of decreasing M1G levels and elevating GST activity. These effects may
contribute to cancer chemoprevention. The results also suggest that
dietary
admixture may be the preferable mode of administration for curcumin in
the
chemoprevention of colon cancer. The chemopreventive efficacy of oral
curcumin
in the colorectum and the liver merits clinical evaluation." - Effects
of
Dietary Curcumin on Glutathione S-Transferase and Malondialdehyde-DNA
Adducts
in Rat Liver and Colon Mucosa, Experimental Therapeutics, Preclinical
Pharmacology "Oral administration of 90 mg of curcumin or the placebo 2
hours
before exercise and immediately after exercise. Curcumin
supplementation
attenuated exercise-induced oxidative stress by increasing blood
antioxidant
capacity." - Int J Sports Med. "In animal oral administration, Curcumin
inhibited lung cancer, skin cancer, head and neck cancer, oral cancer,
hepatocellular carcinoma, mammary tumors, lymphomas, leukemias, and
familial
adenomatous polyposis." - Cancer Res Treat. "Oral treatment of curcumin
found
to effective in diabetic condtion. It attenuated high fat diet-induced
glucose
intolerance and elevations of oxidative stress in the skeletal muscle."
- World
J Diabetes "Curcumin was effective both orally and topically. These
results
show that curcumin enhanced wound repair in diabetic impaired healing,
and
could be developed as a pharmacological agent in such clinical
settings." -
Wound Repair Regen "Our findings indicate that curcumin is a potent
anti-inflammatory agent that prevents the release of TNFα and protects
against
the pulmonary and cardiovascular effects of DEP." - PLoS One "In a
human
clinical trial, 3.6 g of Curcumin via oral route was found to produce a
plasma
curcumin level of 11.1 nmol/L after an hour of dosing." - Clinical
Cancer
Research "The average peak serum concentrations after taking 4,000 mg,
6,000 mg
and 8,000 mg of curcumin were 0.51 microM, 0.63 microM and 1.77 microM,
respectively." - Phase I Clinical Trial of Curcumin, Anticancer
Research
"Traces of curcumin were detected in the plasma. Its concentration in
the small
intestinal mucosa, between 39 and 240 nmol/g of tissue, reflects
differences in
dietary concentration...The comparison of dose, resulting curcumin
levels in
the intestinal tract, and chemopreventive potency suggests tentatively
that a
daily dose of 1.6 g of curcumin is required for efficacy in humans." -
Journal
Cancer Epidemiol Biomarkers "The concentrations of curcumin in normal
and
malignant colorectal tissue of patients receiving 3,600 mg of curcumin
were
12.7 +/- 5.7 and 7.7 +/- 1.8 nmol/g, respectively...The results suggest
that a
daily dose of 3.6 g curcumin achieves pharmacologically efficacious
levels in
the colorectum with negligible distribution of curcumin outside the
gut." -
Cancer Epidemiol Biomarkers "One hour after administration, the levels
of
curcumin in the intestines, spleen, liver, and kidneys were 177.04,
26.06,
26.90, and 7.51 microg/g, respectively." - Journal Drug Metab Dispos.
"Bromelain (pineapple extract) substantially promotes the absorption of
curcumin enhancing its bioavailability, and making this a perfect
combination
of immune-boosting nutraceuticals with synergistic anti-inflammatory
and
anticoagulant actions." - Metabolism "Buttermilk could be used as a
carrier for
curcuminoids especially if delivered with food...The most important and
practical finding from the bioaccessibility data is that the
incorporation of
powdered curcuminoids with buttermilk results in a 15-fold increase in
bioaccessibility of curcuminoids." - Food Chemistry "Curcumin was found
in
plasma (16.1 ng/mL), urine (2.0 ng/mL), intestinal mucosa (1.4 mg/g),
liver
(3,671.8 ng/g), kidney (206.8 ng/g), and heart (807.6 ng/g)." - Journal
Agric
Food Chem. "Curcuminoids were detectable in plasma samples, urine
samples, and
in the colonic mucosa of all 23 biopsied participants. Mean tissue
levels were
48.4 μg/g (127.8 nmol/g) of parent curcuminoids. The major conjugate,
curcumin
glucuronide, was detectable in 29 of 35 biopsies. High levels of
topical
curcumin persisted in the mucosa for up to 40 hours postadministration.
In
summary, pharmacologically active levels of curcumin were recovered
from
colonic mucosa. The regimen used here seems safe, and patients support
its use
in long-term trials." - Cancer Prev Res. "After oral administration of
400 mg
Curcumin to rats, about 60% of the dose was absorbed." - Journal
Toxicology
"Tissue distribution of Curcumin using tritium-labeled drug. They found
that
radioactivity was detectable in blood, liver, and kidney following
doses of
400, 80, or 10 mg of [3H] curcumin. With 400 mg, considerable amount of
radio
labeled products were present in tissues 12 days after dosing. The
percentage
of curcumin absorbed (60-66% of the given dose) remained constant." -
Journal
Toxicology Curcumin rescues breast cells International Journal of
Oncology,
December
2019
Breast cancer is the most prevalent type of cancer among women
worldwide and it
is characterized by a high morbidity. Curcumin is a naturally occurring
compound derived from the rhizome of Curcuma longa and is known to have
antioxidant and anticarcinogenic properties. Curcumin also acted upon
the miRNA
as a regulator of genes implicated in EMT and upon Rho‑A as well,
affecting
the migration and invasion of the cells. This occurred independently of
their
estrogen receptor (ER), progesterone receptor (PgR) and human epidermal
growth
factor receptor 2 (HER2) receptors in the non‑malignant MCF‑10F and
malignant MDA‑MB‑231 breast cell lines, which are both negative for
such
receptors. Turmeric and Inflammatory Diseases: An Overview of Clinical
Evidence
Department of Traditional Pharmacy, December
2019
Turmeric (Curcuma longa L.) and its major ingredients, curcuminoids,
are the
well-known natural products used for the management of several
inflammatory
conditions including inflammatory bowel diseases, irritable bowel
syndrome,
osteoarthritis, rheumatoid arthritis, renal diseases, oral lichen
planus,
gingivitis and periodontitis, radiation-induced oral mucositis and
dermatitis,
psoriasis, and respiratory problems. Main inflammatory markers in
chronic
inflammation include C-reactive protein, tumor necrosis factor-α, and
different interleukins which are assessed in the clinical trials.
Turmeric and
curcumin have demonstrated significant effect in some clinical trials.
Effect
of Curcumin on the Diversity of Gut Microbiota Department of Analytical
and
Food Chemistry, December
2019
Curcumin, the main active component of turmeric (Curcuma longa), is
widely used
as a flavoring and coloring agent in food, and also exhibits multiple
pharmacological activities. It has been traditionally used in Asian
countries
as a medical herb for several pathologies due to its anti-inflammatory,
antioxidant, antimicrobial, antimutagenic, and anticancer properties.
Further,
curcumin may potentially complement the conventional treatment of
insulin
resistant conditions, including obesity, pre-diabetes, metabolic
syndrome, and
type II diabetes. Recently, its potential utility in Auto-Immune
Deficiency
Syndrome (AIDS) had been demonstrated. Antibacterial and Anticancer
Activities
of Turmeric and its Active Ingredient Curcumin Department of
Biotechnology,
Institute of Biosciences and Biotechnology, December
2019
Turmeric (Curcuma longa) contains curcuminoids, and various
sesquiterpenes
which contributes towards a wide array of biological activities, e.g.
anti-inflammatory, wound healing, anticancer, and antibacterial
activities.
Curcuminoids and sesquiterpenes are the main constituents of turmeric,
for
which a plethora of molecular targets, and pharmacological activities
have been
reported. The most studied activity of the curcuminoids present in
turmeric in
the recent year is the anticarcinogenic activity. Experiments have
shown that
curcuminoids modify the gene expression of cancer related markers.
Curcumin has
the potential to regulate genes related to cell division, cell cycle
regulation, and apoptosis. The anticarcinogenic activity of turmeric
has been
studied in case of lung, breast, prostate, ovarian, colorectal cancers,
leukemia, and multiple myelomas. Turmeric significantly inhibits
benzopyrene
induced forestomach papillomas. Dietary turmeric, along with catechin,
is a
chemoprotective agent. Besides anticarcinogenic effect, the
antibacterial
activity of turmeric against various bacteria, such as Streptococcus
aureus,
Trichophyton gypseum, Salmonella paratyphi, and Mycobacterium
tuberculosis has
also been explored. The active ingredients of turmeric can be used as
lead
compounds to design potential drugs for the treatment of different
types of
bacterial diseases and cancers. Curcumin, Gut Microbiota, and
Neuroprotection
Nutrients, December
2019
Curcumin, a nontoxic, naturally occurring polyphenol, has been recently
proposed for the management of neurodegenerative and neurological
diseases. It
is possible that curcumin could exert direct regulative effects
primarily in
the gastrointestinal tract, where high concentrations of curcumin are
present
after oral administration. Indeed, a new working hypothesis that could
explain
the neuroprotective role of curcumin despite its limited availability
is that
curcumin acts indirectly on the central nervous system by influencing
the
“microbiota–gut–brain axisâ€, a complex bidirectional system in
which
the microbiome and its composition represent a factor which preserves
and
determines brain “healthâ€. Interestingly, curcumin and its
metabolites
might provide benefit by restoring dysbiosis of gut microbiome.
Conversely,
curcumin is subject to bacterial enzymatic modifications, forming
pharmacologically more active metabolites than curcumin. These mutual
interactions allow to keep proper individual physiologic functions and
play a
key role in neuroprotection. Can curcumin reduce cardiovascular risk
factors?
Examine.com, December
2019
Curcumin is thought to have multiple possible health benefits. This
meta-analysis zeros in on its effects on cardiovascular risk factors.
Cardiovascular disease (CVD) is the number one cause of death in the
U.S., but
some of the risk factors for CVD are modifiable. One of the most
well-known
risk factors are serum lipid levels, in particular LDL cholesterol and
triglycerides. Researchers and healthcare practitioners alike are
therefore
interested in the potential properties of turmeric, and more
specifically its
active ingredient curcumin, for possible anti-inflammatory and
lipid-lowering
effects. Curcumin has long been touted[2] as having medicinal benefits,
and the
safety of curcumin, even at high doses[3], has been consistently
demonstrated.
Curcumin is a polyphenol shown in preclinical and clinical research to
have
anti-inflammatory[4] properties and its effects have been studied in
people
with numerous disease states[5][6][7]. In studies examining the effects
of
supplemental curcumin on participants with cancer, those receiving
supplementation showed reduced levels of numerous proinflammatory
biomarkers.
Turmeric can help treat oral cancers u4uvoice.com, December
2019
HPV is a virus that promotes the development of cervical and oral
cancer. There
is no cure, but the new findings suggest that curcumin may offer a
means of
future control. Mishra’s research group first noted the effect of
curcumin on
HPV and cervical cancer cells in
2005
. The antioxidant slowed the expression of HPV, suggesting that
curcumin could
control the extent of HPV infection. “Since HPV-related oral cancer
cases are
on the rise, we tested the same hypothesis on oral cancer,†Mishra
explained.
“They turned out to be some very interesting findings.†The new
research
indicates that curcumin turns down the expression of HPV in infected
oral
cancer cells by downregulating the levels of cellular transcription
factors
AP-1 and NF-kB. How to live longer: Five diet tips to prevent disease
and boost
life expectancy Express, December
2019
Curcumin, found in turmeric, is believed to give the yellow spice its
health
properties, and studies have linked it to improved brain function,
lower risk
of heart disease and even cancer prevention. Turmeric is renowned for
its
anti-inflammatory properties. Curcumin has also been linked to an
increased
lifespan in both insects and mice. Curcumin May Help Prevent or Combat
Stomach
Cancer, Study Finds Yoga Esoteric, December
2019
Curcumin – derived from the turmeric plant (Curcuma longa) – has
been used
to impart color and flavor to food in many areas of the world. But long
ago,
scientists discovered that the bright, yellow powder can also help
prevent and
fight stomach cancer. In a study conducted by researchers at the
Federal
University of São Paulo (UNIFESP) and the Federal University of Pará
(UFPA)
in Brazil, the possible therapeutic effects of the pigment were
identified. The
study was part of a Thematic Project supported by São Paulo Research
Foundation, or FAPESP. The findings have been published in the journal
Epigenomics. “We undertook a vast review of the scientific literature
on all
nutrients and bioactive compounds with the potential to prevent or
treat
stomach cancer and found that curcumin is one of them,†said Danielle
Queiroz
Calcagno, first author of the study and a professor at UFPA. The
effects of
curcumin supplementation on body mass index, body weight, and waist
circumference in patients with nonalcoholic fatty liver disease
Phytotherapy
Research, December
2019
Several clinical trials have examined the effects of curcumin
supplementation
on anthropometric variables in NAFLD patients with inconclusive
results.
Curcumin supplementation significantly reduced BMI. These results
suggest that
curcumin supplementation might have a positive effect on visceral fat
and
abdominal obesity that have been associated with NAFLD. Herbs to
control
hypertension and diabetes Times of India, December
2019
Turmeric has a compound known as curcumin in it, which has shown to
control
blood sugar levels as well as prevent the onset of diabetes. In a
nine-month-long study, 240 participants who had pre-diabetes were made
to have
curcumin capsules every day. These people did not develop diabetes by
the end
of nine months. Curcumin prevents high-fat diet-induced hepatic
steatosis in
ApoE−/− mice by improving intestinal barrier function and reducing
endotoxin and liver TLR4/NF-κB inflammation Nutrition &
Metabolism, December
2019
Curcumin is a natural polyphenolic compound present in turmeric and
possesses
antiinflammatory, antioxidant and hepatoprotective properties. In
recent animal
studies, curcumin has been shown to have a protective effects on the
liver
against fat accumulation induced by a high-fat diet. The administration
of
curcumin significantly prevented HFD-induced body weight gain and
reduced liver
weight. Curcumin attenuated hepatic steatosis along with improved serum
lipid
profile. Moreover, curcumin up-regulated the expression of intestinal
tight
junction protein zonula occluden-1 and occludin, which further improved
gut
barrier dysfunction and reduced circulating lipopolysaccharide levels.
Curcumin
also markedly down-regulated the protein expression of hepatic TLR4 and
myeloid
differentiation factor 88 (MyD88), inhibited p65 nuclear translocation
and DNA
binding activity of nuclear factor-κB (NF-κB) in the liver. In
addition, the
mRNA expression of hepatic tumour necrosis factor-α (TNF-α) and
interleukin-1β (IL-1β) as well as the plasma levels of TNF-α and
IL-1β were
also lowered by curcumin treatment. These results indicated that
curcumin
protects against HFD-induced hepatic steatosis by improving intestinal
barrier
function and reducing endotoxin and liver TLR4/NF-κB inflammation. The
ability
of curcumin to inhibit hepatic steatosis portrayed its potential as
effective
dietry intervention for non-alcoholic fatty liver disease (NAFLD)
prevention.
Foods that Can Help Students Regulate Blood Sugar and Prevent Diabetes
University Herald, December
2019
Turmeric -has the most important content called curcumin. It can help
reduce
blood sugar levels and inflammation while protecting against heart and
kidney
disease. Curcumin appears to benefit kidney health in diabetics, thus
it is
important to also include this on your diet because diabetes is one
causes of
kidney diseases. Want to Have a Slim Body? These Kitchen Ingredients
Can Help
You India.com, December
2019
Containing a significant compound called curcumin, turmeric can prevent
you
from becoming obese. It can do so by increasing your body’s
metabolism rate.
Also, it helps in fighting against debilitating conditions like cancer
and
Alzheimer’s disease. Neuroprotective and Neurological/Cognitive
Enhancement
Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s
Disease
International Journal of Molecular Sciences, December
2019
Curcumin has several therapeutic properties that include
anti-excitotoxic,
anti-oxidant, anti-apoptotic, anti-hyperhomocysteinemia and
anti-inflammatory
effects, mitochondrial protection, as well as increasing neuronal
lifespan and
promoting neurogenesis. In addition, curcumin also exerts
anti-amyloidogenic
effects and affects the brain’s tau protein. Accumulating evidence
has
clearly shown the role of the neuroprotective and
neurological/cognitive
enhancement effects of curcumin after brain ischemia-reperfusion injury
with
the phenotype of Alzheimer’s disease. Based on the data presented, it
appears
that curcumin has its own effective therapeutic potential through
anti-amyloid,
anti-tau protein hyperphosphorylation, anti-hyperhomocysteinemia,
anti-oxidant,
anti-inflammatory, and anti-apoptotic effects which clearly indicates
that
curcumin can be used as a neuroprotective substance not only in
ischemic
neurodegeneration but also in a neurodegenerative disease similar to
Alzheimer’s disease as a response to brain ischemia associated with
hyperhomocysteinemia. The available data show that curcumin induces
neuroprotection and neurogenesis and may be a new therapeutic agent for
both
regenerative medicine and for the treatment of neurodegenerative
disorders such
as neurodegeneration after brain ischemia with the phenotype of
Alzheimer’s
disease. Therefore, curcumin may be a promising supplementary agent
against
brain ischemia-reperfusion injury in the future. Indeed, there is a
rational
scientific basis for the use of curcumin for the prophylaxis and
treatment of
ischemic neurodegeneration.These results suggest that curcumin may be
able to
serve as a potential preventive and therapeutic agent in
neurodegenerative
brain disorders. Foods for maintaining healthy arteries The Saxon,
December
2019
Curcumin is an anti-inflammatory substance. This substance does not
allow the
arteries to become hard and accumulate harmful plaque. Turmeric is also
rich in
vitamin B6, which prevents damage of blood vessels and prevents plaque
accumulation. And yet, this spice reduces the level of malicious lipids
and
reduce the oxidation of cholesterol. Protection of Curcumin against
Streptozocin-Induced Pancreatic Cell Destruction in T2D Rats Planta
Medica,
December
2019
As a kind of traditional Chinese medicine extract, curcumin has been
proven to
be effective in inhibiting inflammation and apoptosis in pancreatic
islet β
cells in the streptozotocin-induced diabetes mellitus rat model,
although the
underlying mechanism has not yet been clarified. Curcumin
administration
significantly decreased fasting blood glucose and promoted recovery of
pancreas
function in type 2 diabetes rats. In curcumin-treated rats, the
pancreatic
tissue destruction and apoptosis index were reduced. The expression of
IL-1β,
IL-6, TNF-α, caspase-3, Bax, and malondialdehyde were significantly
reduced,
and Bcl-2, superoxide dismutase 2, and glutathione peroxidase were
significantly increased. Curcumin inhibited the expression of
phosphorylated
JNK and NF-κB proteins to block the RAGE/JNK/NF-κB signaling pathway.
In
conclusion, these results indicate that curcumin blocks the
phosphorylation of
JNK and NF-κB protein to inhibit this signaling pathway, thereby
further
inhibiting inflammation and apoptosis in pancreatic islet β cells.
Curcumin
has potential value for the treatment of diabetes. Potential
therapeutic
effects of curcumin and niacin in rotenone-induced Parkinson’s
disease mice
model Molecular and Cellular Biochemistry, December
2019
Treatment with curcumin, niacin, adenosine A2AR antagonist; ZM241385
and their
combination enhanced the animals’ behavior and restored all the
selected
parameters with variable degrees of improvement. The brain
histopathological
features of hippocampal and substantia nigra regions confirmed our
results. In
conclusion, the combination of curcumin, niacin and ZM241385 recorded
the most
potent treatment effect in Parkinsonism mice followed by ZM241385, as a
single
treatment. ZM241385 succeeded to antagonize adenosine A2A receptor by
diminishing its gene expression and ameliorating all biochemical
parameters
under investigation. The newly investigated agent; ZM241385 has almost
the same
pattern of improvement as the classical drug; Sinemet®. This could
shed the
light to the need of detailed studies on ZM241385 for its possible role
as a
promising treatment against PD. Additionally, food supplements such as
curcumin
and niacin were effective in Parkinson’s disease eradication. The
Protective
Effect of Curcumin Against Cisplatin-Induced Nephrotoxicity
Experimentally in
Rats Archives of Pharmacal Research, December
2019
Curcumin has renal protective properties against kidney damage. The
results
clarified the strong protective effect of curcumin on cisplatin induced
nephrotoxicity in rats at the molecular level. Curcumin is known for
its high
oxygen-radical scavenging and quenching power. It is a scavenger of
free oxygen
radicals and stimulates the activity of additional antioxidant
molecules such
as superoxide dismutase, catalase, and glutathione peroxidase. It is a
bifunctional antioxidant because of its ability to react directly with
reactive
species and to induce an up regulation of various cytoprotective and
antioxidant proteins. Curcumin can react with ROS through its phenolic
and
methoxy groups and it is thought to be one of the mechanisms through
which it
can protect the renal epithelial from ROS activity. Curcumin can
indirectly
induce the expression of cytoprotective proteins such as superoxide
dismutase.
Furthermore, it has been reported that curcumin can increase the
synthesis and
concentration of GSH. In summary, this study demonstrated that curcumin
can
protect against nephrotoxic effects of cisplatin in rats. The
protective effect
of curcumin occurred through the up regulation of antioxidants and
suppression
of oxidative stress markers. Curcumin is a promising therapy for
management of
kidney nephrotoxicity. Spice Stops Cancer, Study Finds The Institute
for
Natural Healing, November
2019
UCLA researchers found that curcumin activates cancer-fighting enzymes
in
patients with head and neck cancers. A
2013
study at the University of North Texas Health Science Center found that
curcumin suppresses pancreatic cancer tumors. A
2006
study published in the journal Neuroscience Letters found that curcumin
induces
cell death in glioblastoma (brain cancer) cells. A Chinese study showed
that
curcumin makes stomach cancer less resistant to chemotherapy. A study
at MD
Anderson Cancer Center showed that curcumin slowed the progression of
multiple
myeloma (blood cancer). With all this evidence (and this is by no means
a
complete list) you may be wondering why curcumin isn’t widely
prescribed for
the prevention and treatment of cancer. People in India get curcumin by
eating
turmeric at almost every meal. Most Americans are not willing to do
this.
That’s why, for most of us, curcumin supplements are the best option
for
cancer prevention. Curcumin is safe for just about everyone. Fat
increases
bioavailability, taking curcumin with a meal that includes fat improves
absorption. Curcumin: hopeful treatment of hemophilic arthropathy via
inhibition of inflammation and angiogenesis Expert Review of
Hematology,
November
2019
Curcumin is known for its strong anti-inflammatory and anti-angiogenic
potentials. This agent is able to inhibit the mentioned inflammatory
and
angiogenic factors such as IL-1, IL-6, TNF-α, VEGF, MMPs, and HIF-1α.
Also,
as well as anti-angiogenic and anti-inflammatory activity, curcumin has
a
strong antioxidant potential and can decrease oxidative stress.Expert
opinion:
It seems that curcumin could be considered as a possible agent for the
treatment of HA through inhibition of inflammation, oxidative stress,
and
angiogenesis. Efficacy of adjuvant curcumin therapy in ulcerative
colitis: A
metaâ€analysis of controlled trials Journal of Gastroenterology and
Hepatology, November
2019
Curcumin, as an adjuvant treatment of mesalamine, was proved to be
effective
and safe in ulcerative colitis. Better efficacy can be achieved with
suitable
dose, delivery way, formation, and intervention time, which needs
further study
to verify. How To Treat Joint Problems: This Anti-Inflammatory Spice
May Be The
Solution IBTimes, November
2019
Another benefit that turmeric is starting to be known for is its
ability to
reduced inflammation, particularly in swollen joints. Research shows
that a
substance called curcumin, which the turmeric roots are abundant with,
provides
a positive impact on the body’s inflammatory pathways. Curcumin gives
turmeric its potent anti-inflammatory properties. Researchers revealed
the many
benefits of turmeric supplements like minimizing inflammation
associated with
rheumatoid arthritis and inflammatory bowel disease or IBS. It has also
been
proven very effective in the treatment of abdominal pain for those who
are
suffering from IBS. While the study on turmeric has been focused on its
ability
to reduce inflammation, researchers say it is also a good source of
strong
antioxidants and minerals. Turmeric root extracts have been observed to
protect
the cells in the body and counter the damage caused by free radicals.
Turmeric
has also been found to be rich in phosphorus, potassium, and manganese.
These
minerals play a vital role in the health of the heart, muscles, and
bones.
Muswell recommends adding turmeric to a regular diet to help increase
the
intake of minerals and antioxidants that the body needs. Curcumin May
Improve
Adipocyte Health, Adiponectin Metabolism Endocrinologyadvisor, November
2019
Curcumin supplementation moderately increases circulating adiponectin,
which
could have beneficial effects on pathways related to adipocyte health
and
adiponectin metabolism, according to study results published in
Diabetology &
Metabolic Syndrome. The therapeutic benefits of curcumin, a bioactive
yellow-orange pigment found in turmeric, have been shown in metabolic
diseases.
The pooled effect sizes showed that curcumin supplementation
significantly
increased adiponectin concentrations vs placebo. Best supplements for
joints:
The exotic spice proven to have anti-inflammatory properties
Express.co.uk,
November
2019
The most researched beneficial substance found in the turmeric root is
curcumin. Yasmin explained: "Turmeric and curcumin, can impact
inflammatory
pathways in the body, giving it it’s powerful anti-inflammatory
properties.
Research has shown benefits of turmeric supplements reducing
inflammation with
inflammatory bowel disease (IBD), rheumatoid arthritis and reducing
abdominal
pain in IBS sufferers. Although much of the research focuses on
reducing
inflammation in these more diagnosable conditions, we can benefit from
anti-inflammatory actions that turmeric has to offer to counterbalance
inflammation coming from a more westernised style diet." Curcumin
lessens
unpredictable chronic mild stress-induced depression and memory
deficits
Pakistan Journal of Pharmaceutical Science, November
2019
Unpredictable chronic mild stress (UCMS) model is the most established
method
to study neurobiological mechanisms of depression. This work was
intended to
explore the efficacy of curcumin to revert the UCMS-induced oxidative
burden
and associated depression as well as potential of curcumin as an acetyl
cholinesterase (AchE) inhibitor. Findings showed that curcumin
supplementation
significantly attenuated the UCMS-induced depression and anxiety like
symptoms,
decreased the load of UCMS propagated oxidative stress by improving
antioxidant
enzymes activities. Curcumin also improved the memory function and
exhibited
inhibitory effect on AchE activity. In conclusion it can be suggested
that
supplementation of curcumin in daily life can help in combating the
stress-induced depression and ever increasing load of oxidative stress.
Study
also highlights the anti-acetylcholinesterase potential of curcumin
which may
be responsible for improved memory function following UCMS. Curcumin
Ameliorates Dermatitis Inflammation Journal, November
2019
Curcumin, extracted from the roots of Curcuma longa, has been used as
an
anti-inflammatory agent since the time of Ayurveda. Overall, our
findings
demonstrate that curcumin treatment blunts the development of AD as
well as
associated atopic march in experimental mice. Curcumin protects sodium
nitrite-induced hepatotoxicity Toxicology Reports, November
2019
Pre-treatment with curcumin significantly (P < 0.05) prevented
these
alterations by adjusting the lipid profile, liver function markers, and
C-reactive proteins and abrogating the elevated markers of oxidative
stress as
supported by the liver histology. This suggests that dietary
consumption of
curcumin is beneficial against NaNO2 induced oxidative stress of the
liver via
its antioxidant potential. Fight Diabetes With Curcumin Only My Health,
November
2019
Curcumin reduced blood sugar and cholesterol levels by reducing
saturated fats
found primarily in dairy products, red meat and helps eliminate trans
fats.
Curcumin prevents Liver Fat accumulation, fats accumulated due to
alcohol
consumption, reducing hepatocellular inflammation. Curcumin is known to
control
white blood cells, which also lead to inflammation in the body.
Curcumin in all
its benefits helps in treating inflammation in the body and further
reduce the
complications, as inflammation is a significant reason for diabetes.
Curcumin
is also essential in reducing resistance to insulin. This ingredient
also helps
insulin get into cells for preventing diabetes. In a study of 240
people, the
only thing that saved people from diabetes and its symptoms was
curcumin.
Around 16% of the 116 people on placebo (inactive treatment) had Type 2
diabetes in nine months. In simpler terms, curcumin is an
“antioxidant.†It
is a known fact that oxygen is an essential component required to live
but also
leads to corrosion. Just like iron rusts in the open air, the reactive
oxygen
species also can lead to rusting of blood vessels and other organs.
This study
also pointed out towards a connection between curcumin and a protection
layer
from oxidation. Curcumin suppresses the Inflammatory process by
inhibiting
various cytokines and interleukins responsible for it. Curcumin for
arthritis
Medical Daily, November
2019
A new study shows that curcumin, a naturally occurring substance in the
spice
turmeric, could help improve the conditions of people with knee
osteoarthritis.
Researchers analyzed the effects of curcumin in 139 people. The
participants
reported moderately severe symptoms of osteoarthritis and took
treatments with
a nonsteroidal anti-inflammatory drug (NSAID). Researchers divided the
patients
into groups that took either diclofenac or curcumin every day for a
month.
Result showed that both treatments provided health benefits.
Researchers said
94 percent of the group that received curcumin and 97 percent of those
under
diclofenac reported up to 50 percent improvement in their arthritis
symptoms.
Curcumin causes less side effects. Some people who took diclofenac
required
treatment for stomach problems after the study, while none of the
participants
taking curcumin experienced similar unwanted effects. ​The Effects of
two
Weeks Exhaustive swimming and Curcumin Supplementation on Liver Damage
Department of Exercise Physiology, November
2019
Curcumin is an active ingredient in turmeric, which is used as herbal
medicine
for the treatment of certain diseases. The reduction of liver damage
markers in
this study suggests that exercise and curcumin consumption may, through
protective effects, improve the negative effects of alcohol on the
liver, and
prevent alcohol induced liver disease. The anti-apoptotic, antioxidant
and
anti-inflammatory effects of curcumin on acrylamide-induced
neurotoxicity in
rats Pharmacology and Toxicology, November
2019
Concurrent administration of curcumin at the oral doses of 50 and 100
mg/kg
with ACR significantly protected the rats from ACR-induced weigh loss
and motor
function deficits, and improved the pathological alterations in the
ACR-intoxicated brains. Curcumin treatment especially at a high dose
enhanced
the TERT mRNA expression level and increased the number of
TERT-positive nerve
cells in cortex tissues of ACR intoxicated rats. The levels of MDA,
TNF-α and
IL-1β in the cerebral homogenates were reduced, the contents of GSH as
well as
the activities of SOD and GSH-Px were increased by curcumin treatment,
compared
to ACR control group. Conclusions: These data suggested the
anti-apoptotic,
antioxidant and anti-inflammatory effects of curcumin on ACR-induced
neurotoxicity in rats. And maintaining TERT-related anti-apoptotic
function
might be one mechanism underlying the protective effect of curcumin on
ACR-intoxicated brains. Curcumin and Type 2 Diabetes Mellitus:
Prevention and
Treatment Nutrients, October
2019
Among these medicinal plants, curcumin is gaining a growing interest in
the
scientific community. Curcumin is a bioactive molecule present in the
rhizome
of the Curcuma longa plant, also known as turmeric. Curcumin has
different
pharmacological and biological effects that have been described by both
in
vitro and in vivo studies, and include antioxidant, cardio-protective,
anti-inflammatory, anti-microbial, nephro-protective, anti-neoplastic,
hepato-protective, immunomodulatory, hypoglycaemic and anti-rheumatic
effects.
In animal models, curcumin extract delays diabetes development,
improves
β-cell functions, prevents β-cell death, and decreases insulin
resistance.
The present review focuses on pre-clinical and clinical trials on
curcumin
supplementation in T2DM and discusses the peculiar mechanisms by which
curcumin
might ameliorate diabetes management. Therapeutic Effects of
Curcumin—From
Traditional Past to Present and Future Clinical Applications
International
Journal of Molecular Sciences, October
2019
The excellent results of the scientific projects that underlie the five
original papers give reason to hope that curcumin will be part of novel
treatment strategies in the near future—either as monotherapy or in
combination with other drugs or therapeutic applications. Curcumin May
Help
Prevent Or Combat Stomach Cancer, Study Finds Waking Times, October
2019
Curcumin — derived from the turmeric plant (Curcuma longa) — has
been used
to impart color and flavor to food in many areas of the world. But long
ago,
scientists discovered that the bright, yellow powder can also help
prevent and
fight stomach cancer. “We undertook a vast review of the scientific
literature on all nutrients and bioactive compounds with the potential
to
prevent or treat stomach cancer and found that curcumin is one of
them,†said
Danielle Queiroz Calcagno, first author of the study and a professor at
UFPA.
Curcumin-Induced Autophagy Augments Its Antitumor Effect against A172
Human
Glioblastoma Cells Biomolecules & Therapeutics, October
2019
Curcumin, from Curcuma longa, is an effective antitumor agent. Although
the
same proteins control both autophagy and cell death, the molecular
connections
between them are complicated and autophagy may promote or inhibit cell
death.
We investigated whether curcumin affects autophagy, which regulates
curcumin-mediated tumor cell death in A172 human glioblastoma cells.
When A172
cells were incubated with 10 μM curcumin, autophagy increased in a
time-dependent manner. Curcumin-induced cell death was reduced by
co-incubation
with the autophagy inhibitors 3-methyladenine (3-MA),
hydroxychloroquine (HCQ),
and LY294002. Curcumin-induced cell death was also inhibited by
co-incubation
with rapamycin, an autophagy inducer. When cells were incubated under
serum-deprived medium, LC3-II amount was increased but the basal level
of cell
viability was reduced, leading to the inhibition of curcumin-induced
cell
death. Cell death was decreased by inhibiting curcumin-induced
autophagy using
small interference RNA (siRNA) of Atg5 or Beclin1. Therefore,
curcumin-mediated
tumor cell death is promoted by curcumin-induced autophagy, but not by
an
increase in the basal level of autophagy in rapamycin-treated or
serum-deprived
conditions. This suggests that the antitumor effects of curcumin are
influenced
differently by curcumin-induced autophagy and the prerequisite basal
level of
autophagy in cancer cells. The Role of Curcumin in the Modulation of
Ageing
International Journal of Molecular Sciences, October
2019
Curcumin causes the elongation of the lifespan of model organisms,
alleviates
ageing symptoms and postpones the progression of age-related diseases
in which
cellular senescence is directly involved. Curcumin is a promising
anti-ageing
compound which is easily available and easy to apply in the diet, as
well as
being safe and not expensive. Curcumin is a widely studied
nutraceutical,
belonging to polyphenols, acquired from the rhizome of a plant Curcuma
longa
(turmeric), a member of the ginger family. The highest achieved serum
level of
curcumin was about 1.77 µM, 1 h after administration, during the oral
ingestion of 8 g of curcumin per day, or even 3.6 µM if such a dose
was
consumed for 3 months. Data collected by curcumin researchers showed a
large
number of beneficial activities for this compound. They mostly concern
its
anti-cancer activity, but, for several years, the amount of data
showing
curcumin’s role in the modulation of ageing has been intensively
growing
Curcumin attenuates MSU crystal-induced inflammation by inhibiting the
degradation of IκBα and blocking mitochondrial damage Arthritis
Research &
Therapy, October
2019
Curcumin administration effectively alleviated MSU-induced inflammation
by
suppressing the degradation of IκBα, the activation NF-κB signaling
pathway,
the damage of mitochondria, and the activity of NLRP3 inflammasome. Our
results
provide a new strategy in which curcumin therapy may be helpful in the
prevention of acute episodes of gout. Turmeric Can Support Your Active
Lifestyle Mind Body Green, October
2019
The anti-inflammatory benefits of turmeric and its compounds called
curcuminoids (specifically curcumin) make the herb work similarly to
the
anti-inflammatory painkillers in our medicine cabinets. Studies have
shown
promising results in turmeric's ability to help manage muscular and
joint pain
after strenuous exercise. The Health Benefits of Turmeric a
Nutritionist Wants
You to Know Yahoo News, October
2019
Several studies have found that the key protective compound in
turmeric, called
curcumin, reduces inflammation, and its effects are on par with some
anti-inflammatory medications. Curcumin also acts as an antioxidant, to
counter
damaging compounds called free radicals, and fight what’s known as
oxidative
stress. In a nutshell, oxidative stress occurs when there is an
imbalance
between the production of cell-damaging free radicals and the body's
ability to
counter their harmful effects. Because of curcumin's anti-inflammatory
and
antioxidant benefits, turmeric has health benefits for skin, preventing
or
helping to repair visible signs of aging. Curcumin has also been shown
to
increase levels of neurotrophic factor (BDNF) in the brain. That’s
crucial,
because BDNF acts as a type of growth hormone that protects the brain
from
age-related decline or damage. Low BDNF levels are tied to depression,
as well
as Alzheimer’s. Turmeric – the Golden Spice and wonder drug Deccan
Herald,
October
2019
Another research finding says: The results obtained from the present
review
revealed that curcumin can be effective in various types of oxidative
associated liver disorders. This potentiality attributes to curcumin
effects on
hepatotoxicity, non-alcoholic steatohepatitis, alcoholic liver disease,
liver
fibrosis and cirrhosis as well as hepatic injury. Experimental evidence
indicates that curcumin exhibits its preventive and curative effect
against
oxidative associated liver diseases. Pre-administration of curcumin
prevents
hyperhomocysteinemia in ethanol-induced gastric ulcer World Journal of
Pharmacy
and Pharmaceutical Sciences, October
2019
Curcumin is a prototype natural product that has been widely recognized
as an
antioxidant and anti-inflammatory agent. In this study, we aimed to
evaluate
the potentialrole of curcumin supplementation in attenuating the
aggressive
effect of alcohol in experimental induced gastric ulcer. Whereas,
pre-treatment
of curcumin prevented the hyperhomocysteinemia and the elevation of
TNF-α
resultingin a depletion of gastric ulcer. We concluded that, curcumin
is
considered a promising supplement in attenuating gastric ulcer through
its
important role in depletion of oxidative stress and inflammation.
Effects of
Curcumin and Silymarin on the bacterium Shigella dysenteriae and
Campylobacter
Journal of Gastrointestinal Cancer, September
2019
In this study, curcumin and silymarin could inhibit the growth of S.
dysenteriae and C. jejuni and 100 μg/ml sub-MIC levels exhibited the
suppression of housekeeping genes. Combating pathogenic bacteria by
compounds
alternative to antibiotics in the era of antibiotic resistance is a
proper
strategy, though more studies using combinations of them are needed.
High blood
pressure: Could this popular spice lower your bp reading? Express,
September
2019
One study suggests the super spice may also help to lower a blood
pressure
spike. According to Dr Sinatra, turmeric’s potential blood pressure
reducing
benefits come from its active ingredient, as he explained: “Its
[turmeric]
yellow colour comes from curcumin — a powerful antioxidant and
anti-inflammatory compound that’s been found to reduce blood pressure
by
lowering the excess platelet aggregation that occurs in sticky,
clot-forming
blood." Turmeric could help to control a soaring blood pressure High
blood
pressure: Turmeric could help to control a soaring blood pressure
(Image: Getty
Images ) Researchers in a study, published in the journal Scientific
Reports,
concluded that curcumin works much the same way as ginger as it
inhibits the
transport of calcium, which acts as a chemical messenger that tells
muscle
cells to contract, thereby dilating the arteries. Therefore, taking
turmeric
for high blood pressure, due to its active ingredient curcumin, could
be an
effective remedy. Anti-infective Properties of the Golden Spice
Curcumin
Frontiers in Microbiology, September
2019
The search for novel anti-infectives is one of the most important
challenges in
natural product research, as diseases caused by bacteria, viruses, and
fungi
are influencing the human society all over the world. Natural compounds
are a
continuing source of novel anti-infectives. Accordingly, curcumin, has
been
used for centuries in Asian traditional medicine to treat various
disorders.
Numerous studies have shown that curcumin possesses a wide spectrum of
biological and pharmacological properties, acting, for example, as
anti-inflammatory, anti-angiogenic and anti-neoplastic, while no
toxicity is
associated with the compound. Recently, curcumin’s antiviral and
antibacterial activity was investigated, and it was shown to act
against
various important human pathogens like the influenza virus, hepatitis C
virus,
HIV and strains of Staphylococcus, Streptococcus, and Pseudomonas.
Turmeric For
Rheumatoid Arthritis Medicaldaily.com September
2019
According to a review article published in the US National Library of
Medicine,
turmeric is rich in curcumin that has an antioxidant effect, lowers
blood
sugar, is anti-inflammatory and affords anticancer benefits. Since
rheumatoid
arthritis is an autoimmune disease that mistakenly attacks healthy
joint
tissue, patients experience inflammation that leads to bone and joint
damage.
The anti-inflammatory properties of turmeric could alleviate its
symptoms.
Curcumin In a
2016
systematic review, researchers measured the effectiveness of turmeric
and
curcumin extracts on arthritis patients. Those who took 1,000
milligrams of
curcumin daily for eight to 12 weeks reduced their pain sensations and
inflammation which are common symptoms of osteoarthritis. Researchers
found
that curcumin extracts are effective in treating these symptoms by
recommending
patients to take nonsteroidal anti-inflammatory drugs (NSAIDs) such as
ibuprofen and diclofenac. They, however, noted that there is a need for
further
research to confirm their findings. Nevertheless, they recommended that
arthritis patients may use curcumin as a dietary supplement while
undergoing
conventional therapy. A subsequent study looked into the effects of
curcumin on
rats with rheumatoid arthritis. Researchers determined that the
component
reduced inflammation and redness among the lab rats by blocking an
intercellular signaling process called mTOR pathway. Curcumin as a
permeability
enhancer enhanced the antihyperlipidemic activity of green tea extract
BMC
Complementary and Alternative Medicinevolume 19, September
2019
Curcumin, obtained from Curcuma longa, is used as bio-enhancer for
anti-microbial agents and anti-cancer drugs. It shows strong
antioxidant,
anti-inflammatory, anti-mutagenic and anti-carcinogenic properties.
Curcumin
can recover chemically-induced oxidative stress as well as increase
xenobiotic
detoxifying enzymes’ activities in both the liver and kidneys and
suppress
lipid peroxidation. Curcumin has low solubility and low permeability
from
intestine due to P-glycoprotein pump (P-gp). Curcumin acts by two
mechanisms:suppression of drug metabolising enzymes in liver and
inducing
changes in drug transporter P-gp. Curcumin is initially absorbed from
intestine, but is effluxed again inside intestine by P-gp. Curcumin and
EGCG
both are effluxed by P-gp; hence curcumin can play a pivotal role of
inhibiting
P-gp, thereby enhancing permeation of EGCG by inhibiting its efflux.
Understanding use of turmeric in herbal medicine Guardian, September
2019
Curcumin, the major active ingredient in Turmeric has a wide range of
medicinal
activities and it is composed of phytochemicals, mineral/vitamins and
dietary
fiber. Minerals in curcumin are magnesium, potassium, sodium, iron,
manganese,
calcium, phosphorus and selenium. The following vitamins are included
in
Turmeric, vitamins C, E, K, B6 and folate. Turmeric is a very good
source of
dietary fiber and fatty acids are w-fatty acid and alpha-linolenic
acid.
Curcumin possesses anticancer properties along with anti-inflammatory,
anti-Alzheimer’s and anti-tumour potentials. It also has
hepatoprotective,
neuroprotective, cardioprotective, anti-rheumatic, anti-diabetic,
hypoglycemic
and analgesic activities. The essential oils in curcumin are
ar-turmerone,
alpha-turmerone and beta-turmerone and they are biologically active
constituents. These essential oils are endowed with anti-cancer,
anti-inflammatory, antimicrobial and antioxidative potentials. The
curcuminoids
and the volatile essential oils are responsible for the health benefits
of
turmeric. 7 Benefits of Turmeric News18.com September
2019
1.Acts against Inflammation: Inflammation can become a major problem
when it
becomes chronic, inappropriately attacks body’s own tissues.
Curcumin, a
compound found in turmeric, is a naturally and strongly
anti-inflammatory. It
matches the effectiveness of some anti-inflammatory drugs, without the
side
effects. 2.Increases Antioxidant Capacity: Antioxidants are beneficial
for the
body as they protect it from free radicals, which tend to react with
important
organic substances, such as fatty acids, proteins or DNA. Curcumin has
powerful
antioxidant effects, which neutralizes free radicals on its own and
stimulates
body’s own antioxidant enzymes. 3.Lowers the risk of heart disease:
Curcumin
can help reverse many steps in the heart disease process, as it
improves the
function of the endothelium, which is the lining of your blood vessels.
4.Helps
in Skin Care: Turmeric keeps the skin healthy in many ways, such as
keeping
pimples at bay by inhibiting the growth of pimple, clearing acne scars
and
making your skin flawless, healing of a cut and soothing skin
irritation, and
fighting signs of ageing like wrinkles and pigmentation by curbing the
growth
of free radicals. 5.Helps in Weight Loss: Turmeric helps in
accelerating the
metabolism rate and letting the body burn a significant number of
calories,
leading to weight loss. It is also useful in reducing fat mass and
detoxification of the liver, which are essential contributors when it
comes to
diet-induced weight loss efforts. 6.Improves Brain Function: Turmeric
is known
to boost cognitive abilities, increase concentration, and boost memory
retention. It also protects the neural pathways from long-term
oxidative stress
and the build-up of plaque. 7.Treats Depression: Curcumin has a similar
effect
like Prozac on patients suffering from depression, mood swings,
anxiety, and
stress, making it a powerful alternative to pharmaceutical routes,
which often
have dangerous or addictive side effects. Curcumin Inhibits
Proliferation and
Migration of A549 Lung Cancer Cells Natural Product Communications,
August
2019
Curcumin is a major component of turmeric with promising
tumor-suppressive
activity; however, its underlying molecular mechanisms need to be
investigated
further. Collectively, our data suggested that curcumin induces
autophagy via
activating the ERK1/2 pathway and the autophagy is important for the
inhibiting
effect of curcumin in lung adenocarcinoma cells. Curcumin plays a dual
role: in
adjuvant therapy and reversal of drug resistance in acute myelogenous
leukemia
journalcmpr, August
2019
The results obtained highlight the potential of curcumin in enhancing
the
efficacy of cyt and overcoming drug resistance in AML. Thus, this study
shows
that curcumin may effectively be used as an adjuvant therapy in AML.
Benefits
of curcumin in brain disorders Biofactors.
2019
August,
2019
Curcumin is widely consumed in Asia either as turmeric directly or as
one of
the culinary ingredients in food recipes. The benefits of curcumin in
different
organ systems have been reported extensively in several neurological
diseases
and cancer. Curcumin has got its global recognition because of its
strong
antioxidant, anti-inflammatory, anti-cancer, and antimicrobial
activities.
Additionally, it is used in diabetes and arthritis as well as in
hepatic,
renal, and cardiovascular diseases. Recently, there is growing
attention on
usage of curcumin to prevent or delay the onset of neurodegenerative
diseases.
This review summarizes available data from several recent studies on
curcumin
in various neurological diseases such as Alzheimer's disease,
Parkinson's
disease, Multiple Sclerosis, Huntington's disease, Prions disease,
stroke,
Down's syndrome, autism, Amyotrophic lateral sclerosis, anxiety,
depression,
and aging. This review also summarizes the ongoing clinical trials on
curcumin
for different neurodegenerative diseases and patent details of
curcuma/curcumin
in India. Cardiac Rehabilitation-Curcumin, Cardiovascular Disease,
Heart
Failure peoplebeatingcancer.com August
2019
Curcumin supplementation can: attenuate adriamycin-induced
cardiotoxicity
reduce my cholesterol reduce my risk of DVT and stroke helps dissolve
my
post-thrombotic syndrome All is one inexpensive, non-toxic nutritional
supplement. If it sounds as though curcumin is a wonder drug, it is.
Curcumin
also is cytotoxic (kills) to my cancer, multiple myeloma. “Curcumin
(diferuloylmethane) is a polyphenol responsible for the yellow color of
the
curry spice turmeric. It has been used in a variety of diseases in
traditional
medicine. Modern scientific research has demonstrated its
anti-inflammatory,
anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular
protective
effects. In this review, we focused mainly on the effects of curcumin
on the
cardiovascular system. The antioxidant effects of curcumin have been
shown to
attenuate adriamycin-induced cardiotoxicity and may prevent diabetic
cardiovascular complications. The anti-thrombotic, anti-proliferative,
and
anti-inflammatory effects of curcumin and the effect of curcumin in
decreasing
the serum cholesterol level may protect against the pathological
changes
occurring with atherosclerosis. The p300-HAT inhibitory effects of
curcumin
have been demonstrated to ameliorate the development of cardiac
hypertrophy and
heart failure in animal models. The inflammatory effects of curcumin
may have
the possibility of preventing atrial arrhythmias and the possible
effect of
curcumin for correcting the Ca(2+) homeostasis may play a role in the
prevention of some ventricular arrhythmias. The preclinical studies
from animal
to clinical data in human are discussed.†Efficacy and safety of
turmeric and
curcumin in lowering blood lipid levels in patients with cardiovascular
risk
factors: a meta-analysis of randomized controlled trials
“Conclusions-
Turmeric and curcumin may protect patients at risk of CVD through
improving
serum lipid levels. Curcumin may be used as a well-tolerated dietary
adjunct to
conventional drugs. Curcumin induced oxidative stress attenuation by
N-acetylcysteine co-treatment Molecular Medicine, August
2019
Curcumin has been shown to have a broad range of antioxidant,
antibacterial,
antifungal, antiviral, anti-inflammatory, anti-proliferative, and
pro-apoptotic
properties (Aggarwal & Sung,
2009
). Curcumin has also been reported to have anti-fibrotic capabilities
in
studies of wound healing, liver fibrosis and lung fibrosis models (Lin
et al.,
2009
; Yao et al.,
2012
; Zhang et al.,
2011
; Smith et al.,
2010
; Chen & Zheng,
2008
). At the molecular level, curcumin has been reported to play an
anti-fibrotic
role by modulating transcription factors such as transforming growth
factor
beta (Chen et al.,
2013
; Liu et al.,
2016
), platelet-derived growth factor, fibroblast growth factor and tumor
necrosis
factor alpha (Shishodia,
2013
; Hua et al.,
2013
; Das & Vinayak,
2014
), all of which are implicated in the pathogenesis of IPF. Due to these
antifibrotic properties of curcumin, a number of investigators have
hypothesized that this compound could serve as a possible therapeutic
for IPF
(Smith et al.,
2010
; Liu et al.,
2016
; Xu et al.,
2007
). These studies focus on the antifibrotic effects of curcumin and,
like many
other in-vitro studies, report a reduction in profibrotic responses
when
pulmonary fibroblasts are treated in isolation. Foods to Feed Both Body
and
Mind Entrepeneur.com August
2019
Turmeric is the spice that gives curry its yellow color. Curcumin is
the main
active ingredient in turmeric. This spice is found in foods from India,
Indonesia and Thailand, and has been shown to have any great health
benefits.
Curcumin is known to boost brain function and lower the risk of brain
disease
because it increases the levels of an important growth hormone in the
brain
known as the brain-derived neurotrophic factor. Many of the studies
researching
the benefits of turmeric use extracts that contain mostly curcumin, in
quantities exceeding one gram per day. In order to get the full
effects, you
may consider taking a supplement that contains curcumin. Yellow curry
spice
turmeric could prevent stomach cancer The London Economic, July
2019
The active ingredient curcumin suppress cancer cells and induces
apoptosis, or
“cell deathâ€, researchers discovered. The review found that
curcumin,
derived from the roots of the turmeric plant, could also work against
gastric
tumors. Professor Danielle Queiroz Calcagno said that researchers
undertook a
vast scientific review. She said: “We looked at all nutrients and
bioactive
compounds with the potential to prevent or treat stomach cancer and
found that
curcumin is one of them. “These compounds can favour the activation
or
repression of genes involved in the development of stomach cancer by
promoting
or inhibiting histone acetylation.†Curcumin influences histones by
inhibiting acetyltransferases to suppress cancer cells and induce
apoptosis, or
cell death. Cellular and molecular mechanisms of curcumin in prevention
and
treatment of disease Critical Reviews in Food Science and Nutrition,
July
2019
Curcumin is known to reverse vari- ous ailments of the nervous system,
cardiovascular system, digestive system, respiratory system, endocrine
system,
renal system, etc. According to recent and well-designed clinical
study,
consumption of curcumin exerts beneficial effect against metabolic
syndrome,
skin diseases, cancer, gut inflammation, depression, arthritis, fatty
liver
disease and premenstrual syndrome. Furthermore, the anti-inflammatory
and
antioxidant potential of curcumin supplementation for its beneficial
effect
against arthritis and metabolic syndrome has been reviewed. Curcumin
has been
reported to bind directly to signaling molecules, such as carrier
proteins, DNA
methyltransferases 1, xanthine oxidase, human immunodeficiency virus
(HIV)- 1
integrase, filamenting temperature-sensitive mutant Z (FtsZ)
protofilaments,
glyoxalase I, proteasome, histone deacetylase, histone
acetyltransferase, cell
survival proteins, HIV-1 protease, protein reductases, protein kinases,
inflam-
matory molecules and metal ions (Gupta et al.
2011
). Curcumin treatment modulated b-secretase 1 (BACE-1),
acetylcholinesterase
(AChE) activity, chemokines, toll-like receptor (TLR), cyclooxygenase
(COX),
brain-derived neuro- trophic factor (BDNF), tropomyosin receptor kinase
B
(TrkB), c-Jun N-terminal kinase (JNK), insulin receptor substrate-1
(IRS-1),
inhibitor of NF-kB (IkB), glutathione-S- transferase, endothelial haeme
oxygenase-1 (HO-1), extracel- lular receptor kinases (ERKs), low
density
lipoprotein-recep- tor (LDL-R), activator protein 1 (AP-1), peroxisome
proliferator-activated receptor-gamma (PPAR-c), liver X
receptor-b(LXR-b),
retinoid X receptor (RXR)-a, c-Jun and tumor necrosis factor alpha
(TNF-a) (Ray
and Lahiri
2009
; Hamaguchi, Ono, and Yamada
2010
; Farooqui
2013
; Tian et al.
2013
). Curcumin treatment is reported to exert its beneficial effect
through
various kinases such as focal adhe- sion kinase (FAK), acid activated
protein
kinase C (AAPK), epidermal growth factor receptor-kinase (EGFRK),
protein
tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK), protein
kinase
A (PKA), protein kinase B (PKB), ERK, p21-activated kinase (PAK), janus
kinase
(JAK), inter- leukin (IL)-1, Rak and pp60C-TK. Curcumin also demon-
strates
significant action via growth factors like fibroblast growth factor
(FGF),
hepatocyte growth factor (HGF), epi- dermal growth factor (EGF),
platelet-derived growth factor (PDGF), transforming growth factor-b1
(TGF-b1)
and vas- cular endothelial growth factor (VEGF). Cytokines such as
IL-1b, IL-1,
IL-6, IL-8, IL-12, TNF-aand monocyte chemo- attractant protein-1
(MCP-1), and
several transcription fac- tors like nuclear factor kappa B (NF-kB),
Ap-1,
Notch-1, CREB-binding protein (CREB-BP), early growth response-1
(Egr-1),
Wilms’tumor gene 1 (WT-1), b-catenin, hypoxia- inducible factor-1
(HIF-1),
nuclear factor 2-related factor (Nrf-2) and estrogen response element
(ERE) are
also the molecular targets of curcumin (Kunnumakkara et al.
2017
; Derosa et al.
2016
; Sahebkar et al.
2016
). Curcumin exerts beneficial effects through various receptor such as
integrin
receptor (IR), Fas receptor (Fas-R), EGFR, HER-2, IL-8R, C- X-C
chemokine
receptor type 4 (CXCR4), estrogen receptor- alpha (ER-a), endothelial
cell
protein C receptor, histamine (2)-receptor (H2R), LDL-R, androgen
receptor (AR)
and DR-5. Anti-infective Properties of the Golden Spice Curcumin
Frontiers in
Microbiology, July
2019
The search for novel anti-infectives is one of the most important
challenges in
natural product research, as diseases caused by bacteria, viruses, and
fungi
are influencing the human society all over the world. Natural compounds
are a
continuing source of novel anti-infectives. Accordingly, curcumin, has
been
used for centuries in Asian traditional medicine to treat various
disorders.
Numerous studies have shown that curcumin possesses a wide spectrum of
biological and pharmacological properties, acting, for example, as
anti-inflammatory, anti-angiogenic and anti-neoplastic, while no
toxicity is
associated with the compound. Recently, curcumin’s antiviral and
antibacterial activity was investigated, and it was shown to act
against
various important human pathogens like the influenza virus, hepatitis C
virus,
HIV and strains of Staphylococcus, Streptococcus, and Pseudomonas.
Despite the
potency, curcumin has not yet been approved as a therapeutic antiviral
agent.
This review summarizes the current knowledge and future perspectives of
the
antiviral, antibacterial, and antifungal effects of curcumin. Wikipedia
Fails
Again: The Case of Misinformation about Curcumin PRN.fm July
2019
Just in the US official scientific library of medicine with almost
12,000
studies, the evidence overwhelmingly supports curcumin’s medicinal
and
functional benefits. That does not include the thousands of studies in
medical
journals in other cournties where turmeric has been used as a
nutritional
enhancer for millennia. Wikipedia’s absurd statement that “although
long
used in Ayurvedic medicine… no high-quality clinical evidence exists
for use
of turmeric or its constituent, curcumin, as a therapy,†requires
little
comment for the hundreds of pages simply listing research about the
herb’s
medicinal value. Just a few of the research study titles include:
Curcumin
administration reduces depressive symptoms in patients with major
depression
(Phytotherapy Research,
2015
) Curcumin or combined curcuminoids are effective in lowering the
fasting blood
glucose concentrations of individuals with dysglycemia (Pharmacological
Research,
2017
) Curcumin appears to enhance clearance of amyloid-beta in
Alzheimer’s
disease patient (Journal of Alzheimers Disease,
2006
) Meta-analysis of randomized controlled trials of 4 weeks or longer
suggest
that curcumin may afford some protection against oxidative stress
(Nutrition
Research,
2018
) A curcumin extract is appropriate for the care of patients with joint
problems and may also contribute to the regeneration of cartilage (Open
Rheumatological Journal,
2014
) A daily dose of 3.6 g curcumin achieves pharmacologically efficacious
levels
in the colorectum with negligible distribution of curcumin outside the
gut
(Cancer Epidemiological Research,
2005
) A topical preparation of curcumin successfully decreased the markers
of
lactational mastitis such as pain, breast tension and erythema within
72 hours
of administration (Oman Medical Journal,
2014
) Curcumin alleviates ethanol-induced oxidative damage in liver cells
(Journal
of Ethnopharmacology,
2010
) We can trust the accumulation of nearly 12,000 studies in the
official peer
reviewed data library. We can count upon the countless other studies in
the
world’s other databases. We can trust the numerous doctors throughout
history
in culture’s worldwide with proven clinical experience. Or we can
trust a
tiny group of expert wannabes, Skeptics, who are anonymous and have no
noticeable education or experience in nutritional biochemistry and
preventative
medicine. And this group dominating Wikipedia’s health pages are
ideologically and frequently politically aligned with the
pharmaceutical
industry. This is a long sorted history of Big Pharma relying upon faux
scientists, public relations firms and astroturf groups for hire to
promulgate
its ideology. Chemopreventive efficacy of oral curcumin: a prodrug
hypothesis
Federation of American Societies for Experimental Biology, July
2019
Oral consumption of curcumin, a natural polyphenol, is associated with
reduced
incidence of cancer. Yet, a significant amount of the orally dosed
compound is
eliminated in the feces, and a major fraction of the absorbed compound
is
metabolized to inactive glucuronides, resulting in poor bioavailability
(<1%).
It is not known how oral curcumin exhibits chemopreventive activity. We
propose
curcumin glucuronide is an inflammation-responsive natural prodrug that
is
converted back to curcumin on demand at the site of action. Our studies
show
elevated levels of β-glucuronidase, an enzyme that hydrolyzes the
glycosidic
bond of glucuronides to generate the parent compound, in human breast
cancer.
Oral administration of curcumin in mouse tumor models generated
significant
tumor levels of the polyphenol. Intravenous administration of the
glucuronide
resulted in the formation of curcumin in the tumor tissue. Chronic
daily oral
curcumin dosing led to tumor accumulation of curcumin and inhibition of
tumor
growth in tumor models with high β-glucuronidase activity. Overall,
the study
presented here provides preliminary evidence for a novel mechanism of
action
for orally administered curcumin. How Turmeric Can Help in Weight Loss
Latestly.com, July
2019
Curcumin is an antioxidant and anti-inflammatory ingredient found in
turmeric
with weight loss benefits. According to a study conducted by
researchers at
Tufts University in
2009
, curcumin slowed weight gain in mice by preventing new fat tissues
from
forming. When mice were fed with turmeric it prevented them from
developing new
blood vessels and less fat tissue. The study also revealed that mice
who were
fed with this anti-oxidant agent had less fat in their livers and lower
cholesterol levels than mice who weren’t. As per the latest study
conducted
by The Journal of Nutritional Biochemistry, Korean scientist identified
that
curcumin induces browning in white adipose tissue. There are two types
of
adipose tissues -- brown and white. White adipose tissue stores energy
and
increases with weight gain. On the other hand, brown adipose tissue
produces
heat by burning fat. Curcumin in turmeric stimulates the production of
mitochondria which converts sugars, proteins and fat into energy.
Effects of
Turmeric on Your Body Galpost.com, July
2019
Scientists have discovered that curcumin inhibits the production of fat
cells
and improves the metabolism of carbohydrates, which reduces fat after
eating
bread, pasta, potatoes and other carbohydrates. Why All Diabetics
Should Know
About Turmeric I Thrive Series, July
2019
A recent literature review published in the International Journal of
Endocrinology and Metabolism titled, “Anti-Hyperglycemic Effect and
Insulin
Sensitizing Effects of Turmeric and Its Principle Constituent
Curcumin,†adds
promising new support to the notion that the ancient Indian spice
turmeric may
provide an ideal drug alternative to treating and perhaps even
preventing type
2 diabetes, which has become of the world’s most prevalent diagnoses.
The
study reviewed research published between 1998 to
2013
that indicates the active polyphenol in turmeric known as curcumin may
provide
an ideal intervention for type 2 diabetes, capable of mitigating
characteristic
pathophysiological hallmarks of the disease such as elevated blood
sugar
(hyperglycemia) and insulin resistance. Nineteen of the studies
reviewed were
cell (in vitro) and animal (in vivo), all which showed beneficial
effects. Five
of the studies were human clinical trials using turmeric or curcumin,
three of
which were performed in those with either diabetes or prediabetes.
Amazingly,
the animal and cell research literature review concluded that curcumin
could
improve the type 2 diabetic state through 10 distinctly different
mechanisms,
such as: Reduction in liver glucose production Reduction in liver
glycogen
production Stimulation of increased glucose uptake (by increasing
GLUT4, GLUT2
and GLUT3 gene expressions) Increasing the activation of AMP kinase
Promoting
PPAR γ ligand- binding activity Suppressing hyperglycemia-induced
inflammatory
state Stimulating insulin secretion from pancreatic tissues Improvement
in
pancreatic cell function, Increasing phosphorylation of AKT Increasing
insulin
receptor β and reduction of insulin resistance The human clinical
research
conducted on diabetic and pre-diabetic patients revealed that curcumin
had the
following beneficial effects: Glucose lowering effect Improved beta
cell
function Improved fatty acid oxidation and utilization Effects of Notch
Signaling Pathway in Cervical Cancer by Curcumin Journal of Cancer,
July
2019
Curcumin, as a high effectand low toxicity anti-cancer drug and
photosensitiser, has synergisticand complementaryeffects with
photodynamic
therapy. We found both DAPT and curcumin-PDT can inhibit the
proliferation and
induce apoptosis of cervical cancer cell. Can Turmeric Help Prevent or
Treat
Type 2 Diabetes? Everydayhealth.com, July
2019
The likely driver of turmeric’s potential health benefits is
curcumin, the
primary active chemical in this yellow-orange spice. “Curcumin is
what has
mostly been studied because of its important signaling pathways. It
acts mostly
in two areas: It's an antioxidant and an anti-inflammatory,†says
Marina
Chaparro, RDN, MPH, a certified diabetes educator and a national
spokesperson
for the Academy of Nutrition and Dietetics. a study published in April
2015
in the Indian Journal of Clinical Biochemistry found that human
participants
who supplemented their Glucophage (metformin) — a diabetes medication
that
helps lower blood sugar — with turmeric did lower their blood sugar,
inflammation, and levels of oxidative stress. In another human study
— this
one a randomized controlled trial that was published in
2012
in Diabetes Care — a supplement of 250 milligrams of curcumin daily
was
associated with a delay in participants progressing from prediabetes to
type 2
diabetes. Researchers studied 240 people for nine months and reported
that at
the end of the study, 16.4 percent of people in the placebo group
developed
type 2 diabetes, versus 0 percent in the curcumin-supplemented group.
Participants didn’t report any side effects except for mild
stomachaches.
Furthermore, in the Diabetes Care study, curcumin notably appeared to
help
improve the function of beta cells, which research shows help produce
the
hormone insulin. Insulin is responsible for ferrying glucose to cells,
but in
type 2 diabetes, cells become insensitive to glucose, leading to high
blood
sugar. As the pancreas cranks out more insulin to try to lower blood
sugar
levels, blood sugar remains elevated because of insulin resistance —
until it
wanes in producing insulin because of beta cell dysfunction.
Pharmacognostic
Studies on Curcuma Longa International Journal of Pharmacognosy and
Chinese
Medicine, July
2019
The turmeric (Curcuma longa) plant, a perennial herb belonging to the
ginger
family, is cultivated extensively in south and southeast tropical Asia.
The
rhizome of this plant is also referred to as the “root†and is the
most
useful part of the plant for culinary and medicinal purposes. The most
active
component of turmeric is curcumin, which makes up 2 to 5% of the spice.
The
characteristic yellow color of turmeric is due to the curcuminoids.
Curcumin is
an orange–yellow crystalline powder practically insoluble in water.
Turmeric
is used as a dietary spice, coloring agent in foods and textiles, and a
treatment for a wide variety of ailments. It is widely used in
traditional
Indian medicine to cure biliary disorders, anorexia, cough, diabetic
wounds,
hepatic disorders, rheumatism, and sinusitis. Turmeric paste in slaked
lime is
a popular home remedy for the treatment of inflammation and wounds. For
centuries, curcumin has been consumed as a dietary spice at doses up to
100
mg/d. Extensive investigation over the last five decades has indicated
that
curcumin reduces blood cholesterol, prevents LDL oxidation, inhibits
platelet
aggregation, suppresses thrombosis and myocardial infarction (MI),
suppresses
symptoms associated with type II diabetes, rheumatoid arthritis,
multiple
sclerosis (MS), and Alzheimer’s disease, inhibits human
immunodeficiency
virus (HIV) replication, enhances wound healing, protects from liver
injury,
increases bile secretion, protects from cataract formation, and
protects from
pulmonary toxicity and fibrosis, is an anti-leishmaniasis and an
antiatherosclerotic. Additionally, there is extensive literature that
suggests
that curcumin has potential in the prevention and treatment of a
variety of
other diseases. Turmeric and its medicinal properties Guardian, July
2019
Curcumin is the yellow pigment in Turmeric and the most medicinally
active
compound therein. Curry, the very common spice that we add to our stews
and
soups is from curcumin. There are about100 chemical compounds in
turmeric.
These chemical compounds confer certain uniqueness to this herb and
give it the
ability to treat several disease conditions. The curcumin in turmeric
is made
up of polyphenols, which are organic chemicals that possess
anti-inflammatory
properties. Polyphenols are also present in some other types of foods
and
beverages also. Examples of these are epigallocatechin gallate (ECGC)
found in
green tee, resveratrol in red grapes and red wine and capsaicin in
chili
peppers. Curcumin is part of a group of chemical compounds known as
curcuminoids and others in the group are demethoxycurcumin and
bisdemethoxycurcumin. Curcumin is what is responsible for the health
benefits
of turmeric. Tips to increase brain power Newstracklive.com, July
2019
Turmeric: The curcumin in turmeric is antidepressant and helps improves
memory.
It has been found that people suffering from Alzheimer’s have small
proteins
called amyloid-beta which causes damage to the brain. It is neurotoxic
and
forms neurofibrillary tangles in the brain that leads to Alzheimer’s.
Curcumin works to protect the brain from this damage. The Wonders of
Turmeric:
Why It’s Good For You Society19, July
2019
One of the reasons why turmeric is good for you because it is
anti-inflammatory. Turmeric contains curcumin, a chemical that not only
is
responsible for the bright yellow colour, but is said to contain
anti-inflammatory properties. In some cases, curcumin is so potent that
it can
be as effective as anti-inflammatory drugs. One study actually
discovered that
curcumin was more effective in fighting against inflammation than
aspirin and
ibuprofen. Another reason why this spice is good for you is that it can
prevent
cancer. As mentioned above, curcumin has anti-inflammatory properties,
but that
is not the only thing it can do. Curcumin is also beneficial in
treating
cancer, as it affects cancer growth and development. One study has
discovered
that curcumin can inhibit tumor initiation and promotion, as well as
inhibit
metastasis and cell proliferation. Considering that turmeric contains
curcumin,
it is no surprise that the yellow spice is beneficial to the joints and
can
prevent them from getting swollen and inflamed. It has been discovered
that
curcumin is able to help with arthritis, including rheumatoid
arthritis, to the
point that it is considered to be more effective than anti-inflammatory
drugs.
Turmeric, ‘The Golden Spice’ is 1 of the Most Beneficial Spices in
World
Live Trading News, July
2019
Turmeric, known as ‘The Golden Spice of Life’ is of the most
beneficial
spices in the culinary world. It is due to the astounding amounts of
curcumin
it contains, its principal bioactive component. According to a Y
2017
study published in the journal Foods, curcumin contains antioxidant and
anti-inflammatory properties since ancient times known to assist in
alleviating
arthritis, metabolic syndrome and hyperlipidemia. A
2016
study from Drug Design, Development and Therapy showed that
curcuminoids and
curcumin extracts helped alleviate pain and improved both physical
function and
quality of life.7 •May help improve behavioral symptoms of
Alzheimer’s and
dementia — A Y
2012
study found that the daily administration of turmeric to Alzheimer’s
disease
and dementia patients helped reduce irritability, agitation, anxiety,
apathy
and other Alzheimer’s disease symptoms. •Provides an immune system
boost
— According to a Y
2018
study from the Journal of Cellular Physiology, curcumin affects
numerous immune
cells, including natural killer cells and B lymphocytes, supporting the
body
against immune system-related diseases. Life-saving compound can
DESTROY
stomach cancer Healthier Talk, July
2019
Curcumin appears to attack the protein that keeps the DNA of each
cancer cell
in order. So essentially it causes the DNA to unravel – forcing those
cells
to die. While this animal study isn’t quite on the same level as a
controlled
clinical trial, the evidence has been building for years. And the signs
all
point to curcumin being a potent weapon in the war against stomach
cancer.
Curcumin could starve cancer cells In
2017
, a study even showed WHY curcumin is so effective: The acids in your
stomach
can act like fertilizer for these cancers. The tumors suck it up and
use it to
GROW. Curcumin can help tame those acids, not necessarily by reducing
the
levels but changing how they’re secreted so less gets to the tumor.
As a
result, the cancer cells in the study weren’t able to get that
fertilizer…
and DIED because of it. More study is needed, of course. But that makes
curcumin one of the most promising natural therapies yet in the fight
against
stomach cancer. That could mean that if you DON’T have cancer,
curcumin
supplements can prevent it from forming and taking hold. And if you DO
have
cancer, curcumin could help fight it off. Natural Remedies Proven to
Help
Control Pain Care2, July
2019
Scientists believe most of turmeric’s health benefits come from its
high
curcumin content. One of curcumin’s proven abilities is helping to
combat
pain, such as muscle pain and post-surgical pain. In an Indian study,
curcumin
was shown to be more effective for relieving rheumatoid arthritis pain
than
standard drug treatment. You can buy prepared turmeric and curcumin
supplements. Fresh or dried turmeric is also easy to incorporate into
many
different dishes and include in your daily diet. The curcumin in
turmeric can
be difficult to digest, but research has shown that curcumin is much
more
easily absorbed when it’s eaten with black pepper and fats. So, add a
dash of
pepper and a dab of olive, coconut or other healthy oil in your meals
to get
the most pain-fighting action out of your turmeric. Modulatory effects
of
curcumin on heat shock proteins in cancer: A promising therapeutic
approach
Biofactors, July
2019
Curcumin (diferuloylmethane) is a potent antiâ€inflammatory,
antioxidant,
antimicrobial, and antitumor agent. Curcumin has been shown to regulate
different members of HSPs including HSP27, HSP40, HSP60, HSP70, and
HSP90 in
cancer. Here, we present extent findings suggesting that curcumin may
act as a
potential therapeutic agent for the treatment of cancer through its
regulation
of HSPs. Curcumin: a therapeutic strategy in cancers by inhibiting the
canonical WNT/β-catenin pathway Journal of Experimental and Clinical
Cancer
Research, July
2019
Numerous studies have presented that curcumin could have a positive
effect in
the prevention of cancer and then in tumor therapy. Several hypotheses
have
highlighted that curcumin could decreases tumor growth and invasion by
acting
on both chronic inflammation and oxidative stress. Curcumin (1,7-bis
(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a natural
product
which occurs polyphenolic phytochemical properties from the rhizome of
the
Curcuma longa. Curcumin has been discovered in 1815 by Vogel and
Pelletier. Its
yellow-colored hydrophobic component is traditionally used in Asian
countries
for its several properties against pathophysiological states including
anticancer . Several targets of curcumin have been shown to have
chemotherapeutical properties. Curcumin use may have a major role in
the
control of inflammation, angiogenesis, metastasis and proliferation .
Curcumin
can downregulate numerous pathways, such as nuclear factor-Ï° B
(NF-Ï°B),
cyclooxygenase-2 (COX-2), and the canonical WNT/β-catenin pathway. The
use of
curcumin, which acts as PPARγ agonists, could be interesting in the
reduction
of both chronic inflammation and oxidative stress, and in the control
of
circadian clock by inhibiting the WNT/β-catenin pathway. Due to the
considerable impact of cancers on mortality and morbidity rates
worldwide, it
would appear of the utmost importance to better understand the action
of
curcumin in cancers and particularly its role in the inhibition of the
major
signaling system known as the WNT/β-catenin pathway. Discover The
Proven
Health Benefits Of Turmeric And Curcumin Scoopify, July
2019
Curcumin benefits in the prevention of the growth of the precancerous
cells in
the colon. Not only this, it has been highly beneficial in the
treatment of the
breast, stomach and skin cancer during the initial phase. Curcumin has
the
presence of anti-inflammatory and antioxidant properties that help in
maintaining the insulin level in the body. Feed addition of curcumin to
laying
hens showed anticoccidial effect, and improved egg quality and animal
health
Pubmed, July
2019
The addition of curcumin in the diet of laying hens has an
anticoccidial effect
and improves egg quality. Curcumin Induces Oxidative Stress in Botrytis
cinerea
Pubs.acs.org, July
2019
Curcumin exhibits efficient antimicrobial activity; nevertheless, its
effect on
the postharvest decay of fruit has not been examined. Curcumin can be
used to
control gray mold and elevate antioxidant activity in kiwifruit. Health
Benefits of Turmeric & Curcumin OrganicFats.net June
2019
The amazing health benefits of turmeric and curcumin include the
ability to
reduce inflammation, heal wounds, improve skin health, protect
cognitive
abilities, and ease menstrual difficulties. Turmeric also helps
eliminate
depression, alleviate pain, slow down aging, protect the digestive
tract, and
prevent cancer. Turmeric rich in curcumin and vitamin B6 also boosts
your
cardiovascular health. Vitamin B6 can efficiently inhibit the
production of
homocysteine, which is a negative by-product that damages cell walls.
These
weakened walls can cause a number of complications in the heart,
particularly
when exacerbated by high blood pressure or plaque build-up. Curcumin
directly
balances your cholesterol levels by eliminating excess LDL (bad)
cholesterol
from the arteries and blood vessels. This can help prevent
atherosclerosis and
when combined with stronger blood vessels, the herb represents a
comprehensive
solution for a wide range of heart issues, as per a study cited in the
Basic
Research in Cardiology. Anti-cancer Properties A study conducted on
mice by the
researchers at the Cancer Research Institute, Tata Memorial Center,
Mumbai,
India documents the potential protective effect of turmeric on stomach
and skin
cancer. The most extensive research on turmeric’s cancer prevention
effects
has been in colon cancer, whereas other types of cancer research
related to
curcumin are currently underway. Additionally, an animal study by
Ramadasan
Kuttan et al. (Cancer Letters Journal) indicated that the turmeric
extract and
curcumin inhibited the growth of the tumor. Researchers at The
University of
Texas M. D. Anderson Cancer Center found that curcumin’s potential
ability to
kill cancer cells can be used in drug development. Additional studies
need to
be done to get the health benefits of this spice pertaining to cancer.
Prevents
Alzheimer’s As a powerful antioxidant herb, turmeric can stimulate
neural
activity and prevent cognitive degradations, which often come in the
form of
Alzheimer’s and dementia. As per a study by Srikant Mishra from the
Department of Neurology, Plummer Street, Sepulveda, CA, curcumin is
highly
efficient in clearing out the amyloid plaque, which is a major
indicator of
Alzheimer’s progression. A study also found that turmeric supplements
improved mood and cognitive function in non-demented older people
suffering
from mild age-related memory issues. Evaluating the effect of curcumin
for
treatment of cancer anorexia-cachexia syndrome in solid cancer
patients.
Journal of Clinical Oncology, June
2019
Curcumin has been shown anti-cancer and anti-inflammatory effects,
including
attenuation of CACS in animal models. Notably, patient with curcumin
had less
reduction of hand-grip muscle strength on both hands [right hand: -2.09
in
curcumin versus -3.68 in placebo; p = 0.46], [left hand: -1.24 versus
-5.04;
p-value = 0.12], and basal metabolic rate than placebo group. A network
pharmacology approach to investigate the pharmacological effect of
curcumin and
capsaicin targets in cancer Journal of Proteins and Proteomics, June
2019
Curcumin and capsaicin play a vital role in anti-inflammatory and
anti-cancer
mechanism as they are used as therapeutic drugs/adjuvants. The gene
ontology
analysis made it possible to identify a library of possible cancer
targets of
curcumin (34 targets) and capsaicin (35 targets). Based on topological
analysis, the unique target of curcumin and capsaicin was proposed by
identifying essential bottleneck/hub node MAPK1. The docking results of
MAPK1
with curcumin (− 7.6 kcal/mol) has shown good inhibitory effect
similar to
that of standard control ulixertinib (− 8.1 kcal/mol) compared with
capsaicin (− 6.0 kcal/mol). Based on the molecular interaction,
MAPK1
identified through the network pharmacology approach could be a
probable target
of curcumin and capsaicin to prevent angiogenesis in cancer. Curcumin
reverses
oxaliplatin resistance in human colorectal cancer OncoTargets and
Therapy, June
2019
Studies have shown that curcumin regulated EMT processes in many human
cancers.
The OXA-resistant cell line HCT116/OXA was successfully established,
and
combination of OXA with curcumin reduced OXA resistance in vitro.
Besides, the
combination treatment inhibited the expressions of p-p65 and Bcl-2, but
increased the level of active-caspase3. In addition, curcumin inhibited
EMT via
regulation of TGF-β/Smad2/3 signaling pathway. Moreover, in vivo study
confirmed curcumin could reverse OXA resistance in CRC. Conclusion: Our
study
indicated that curcumin could reserve OXA resistance in CRC through
dampening
TGF-β/Smads signaling in vitro and in vivo. Curcumin suppresses
epithelial-to-mesenchymal transition of peritoneal mesothelial cells
Cellular &
Molecular Biology Letters, June
2019
urcumin reversed growth inhibition and migration capability of human
peritoneal
mesothelial cells (HPMCs). In HMrSV5 cells, high glucose PDS also
decreased
expression of epithelial markers, and increased expression of
mesenchymal
markers, a characteristic of EMT. Real-time RT-PCR and western blot
revealed
that, compared to the 4.25% Dianeal treated cells, curcumin treatment
resulted
in increased expression of E-cadherin (epithelial marker), and
decreased
expression of α-SMA (mesenchymal markers) (P < 0.05).
Furthermore,
curcumin reduced mRNA expression of two extracellular matrix protein,
collagen
I and fibronectin. Curcumin also reduced TGF-β1 mRNA and supernatant
TGF-β1
protein content in the PDS-treated HMrSV5 cells (P < 0.05).
Furthermore, it
significantly reduced protein expression of p-TAK1, p-JNK and p-p38 in
PDS-treated HMrSV5 cells. Conclusions. Our results demonstrate that
curcumin
showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells
and
suggest implication of the TAK1, p38 and JNK pathway in mediating the
effects
of curcumin in EMT of MCs. Curcumin and Intestinal Inflammatory
Diseases:
Molecular Mechanisms of Protection International Journal of Molecular
Sciences,
June
2019
Curcumin, the biologically active, hydrophobic, phenolic component of
turmeric
(Curcuma longa), is a natural product commonly utilized in Ayurdevic
and
traditional medicine, both topically and orally, for its potent effects
on
multiple body systems. Curcumin, also known as diferuloylmethane, has
been a
popular supplement largely because of its affordability and safety,
with no
known toxic side effects in humans up to doses of 12 g/day. In this
review, we
discussed the potential protective effects of curcumin on intestinal
inflammatory diseases. Recent research has focused on the effects of
natural
anti-inflammatories, such as curcumin, on intestinal inflammatory
diseases,
largely due to their safety profile and affordability. Curcumin is
characterized by beneficial effects on the microbiome, antimicrobial
properties, inhibition of TLR4/NF-κB/AP-1 signal transduction, changes
in
cytokine profiles, and alterations to immune cell maturation and
differentiation. The culmination of the vast number of effects of
curcumin on
the intestinal epithelium and immune system is to strengthen the
intestinal
barrier through a reduction in bacterial translocation and
inflammation.
Curcumin may play a significant role in intestinal inflammatory disease
treatment in the future, particularly as an adjuvant therapy. Curcumin
and its
Potential for Systemic Targeting of Inflamm-Aging and Metabolic
Reprogramming
in Cancer International Journal of Molecular Sciences, June
2019
The natural source of curcumin is the rhizome of the medicinal plant,
Curcuma
longa, a perennial herb in the family Zingiberaceae. The curcuminoid
complex,
found in the rhizome of turmeric (2.5–6%) contains: curcumin (CUR -
diferuloylmethane, ~85%); demethoxycurcumin (DEM, ~15%);
bis-demethoxycurcumin
(bis-DEM, ~5%) and cyclocurcumin. Pleiotropic effects of curcumin have
been the
subject of intensive research. The interest in this molecule for
preventive
medicine may further increase because of its potential to modulate
inflamm-aging. Curcumin’s binding to various proteins, which was
shown to be
dependent on cellular oxidative status, is yet another feature for
exploration
in depth. Finally, the binding of curcumin to various metabolic enzymes
is
crucial to curcumin’s interference with powerful metabolic machinery,
and can
also be crucial for metabolic reprogramming of cancer cells. This
review offers
a synthesis and functional links that may better explain older data,
some
observational, in light of the most recent findings on curcumin.
Curcumin: A
Potent Protectant against Esophageal and Gastric Disorders
International
Journal of Molecular Sciences, June
2019
Turmeric obtained from the rhizomes of Curcuma longa has been used in
the
prevention and treatment of many diseases since the ancient times.
Curcumin is
the principal polyphenol isolated from turmeric, which exhibits
anti-inflammatory, antioxidant, antiapoptotic, antitumor, and
antimetastatic
activities. The existing evidence indicates that curcumin can exert a
wide
range of beneficial pleiotropic properties in the gastrointestinal
tract, such
as protection against reflux esophagitis, Barrett’s esophagus, and
gastric
mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs)
and
necrotizing agents. The role of curcumin as an adjuvant in the
treatment of a
Helicobacter pylori infection in experimental animals and humans has
recently
been proposed. The evidence that this turmeric derivative inhibits the
invasion
and proliferation of gastric cancer cells is encouraging and warrants
further
experimental and clinical studies with newer formulations to support
the
inclusion of curcumin in cancer therapy regimens. Curcumin, the natural
phenolic active ingredient of turmeric (Curcuma longa) rhizome, has
been used
in Asia as an herbal remedy for a variety of diseases. In addition to
the use
of curcumin as an anti-inflammatory in ancient times, it has also been
used to
treat gastrointestinal (GI) diseases such as indigestion, flatulence,
diarrhea,
and even gastric and duodenal ulcers. Recently, great attention has
been paid
to the medical applications of curcumin in the treatment of human
diseases
associated with oxidative stress and inflammation, including different
cancers.
Curcumin treatment has also led to the improvement of metabolic
parameters
involving aging-associated diseases such as atherosclerosis, diabetes,
cardiovascular disease, and chronic kidney diseases. Interestingly,
some
promising effects of curcumin have been observed in the alleviation by
this
turmeric derivative of the chronic inflammatory conditions such as
arthritis,
uveitis, and inflammatory bowel disease. In some instances, curcumin
has been
found to aid in the prevention and treatment of various cancers.
Recently, the
anticarcinogenic activity of curcumin has been documented in the GI
tract
because this compound has proven to exert a therapeutic effect on
different
human GI cancers such as esophageal, gastric, and small and large
intestinal
cancer. Curcumin in Autoimmune and Rheumatic Diseases Nutrients, June
2019
Curcumin is the main component of turmeric, also known as the Curcuma
longa,
which belongs to the ginger family, Zingiberaceae. Curcumin is commonly
used in
Indian and Asian cooking as a spice for its flavor and yellow color
profile. In
addition to its consumption due to flavor, curcumin has been used for
its
medicinal properties for thousands of years. The curcuminoids found in
turmeric
are curcumin, desmethoxycurcumin, and bisdemethoxycurcumin, with
curcumin being
the main active component. Curcumin was first isolated from turmeric in
1815.
Curcumin gives turmeric its yellow color and is known to possess most
of the
therapeutic effects of turmeric. In 1937, the first article published
on the
use of curcumin in treating human disease cited its beneficial effects
in
biliary disease. Since then, continued research has shown that curcumin
can
alleviate a number of human diseases. Studies performed on animals have
shown a
direct relationship between increased cellular curcumin concentrations
and its
ability to modulate inflammatory mediators. Experimental studies on
cell lines
and humans have confirmed the findings from animal studies,
demonstrating that
curcumin plays a role in anti-inflammatory response via inhibition of
the COX-2
pathway and NF-kB activation. In more recent years, numerous studies
have shown
that curcumin possesses potential anti-inflammatory, anti-oxidant,
anti-diabetic, and anti-cancer properties. These studies indicate that
curcumin
acts on numerous targets with various mechanisms of action, altering
enzyme,
receptor, and transcription factor activity. In addition, curcumin
administration has reported nearly no side effects, making it a
potential
alternative to NSAIDs and other medications with known severe adverse
effects.
Curcumin has been used in Indian and Asian medicine for its therapeutic
abilities for thousands of years. Recent studies provide evidence that
increased curcumin levels can modify cellular disease mechanisms toward
a more
anti-inflammatory profile. This mainly occurs by inhibition of the COX
and
lipoxygenase pathway. Additionally, curcumin suppresses NF-κB pathway
to
decrease inflammation. In addition to its anti-inflammatory effects,
curcumin
also exerts anti-oxidative capacity. The involvement of these pathways
in
normal rheumatic disease progression could possibly explain
curcumin’s
therapeutic effects targeting these disease processes. Many positive
outcome
clinical trials in OA present solid evidence of curcumin’s beneficial
role in
disease progression. In addition, curcumin shows similar efficacy to
common
NSAIDs such as ibuprofen, which cause serious GI side effects.
Conversely,
curcumin has shown to have little or no side effects. Foods That Help
Fight
Anxiety News 18, June
2019
Turmeric: The spice contains curcumin, a compound that promotes brain
health
and prevents anxiety disorders. Curcumin may boost omega-3 fatty acid
DHA in
the brain by helping the body produce it more effectively. Curcumin
also has
powerful antioxidant and anti-inflammatory properties that help prevent
damage
to brain cells. The effect of ultraviolet radiation and the antioxidant
curcumin on the longevity, fertility, and physical structure of
Drosophila
melanogaster Emerging Investigators, June
2019
Curcumin significantly prolonged lifespan and enhanced fertility for
both UV-
and non-UV-exposed flies. Therefore, we conclude that curcumin can
prolong
lifespan, enhance fertility, and mitigate the deleterious effects of UV
radiation on Drosophila. Our research demonstrates that we can harness
the
positive potential of natural antioxidants and use them as weapons in
our war
against radiation-induced diseases, including conditions like cancer.
The
Inhibitory Effect of Curcumin on Ornithine Decarboxylase against
Hepatic
Carcinoma Journal of Biosciences and Medicines, June
2019
Curcumin the active component of turmeric is widely used as an
anticancer agent
for treating many human cancers. Our results showed that curcumin has
the
ability to inhibit the proliferation of HepG2 cells with IC50 of 24.79
μg/ml
and induced G2/M cell cycle arrest. Moreover, it caused an elevation in
the
intracellular concentration of Ca2+. Moreover, in the curcumin
administration
the downregulation expression level of ODC and Bcl-2 genes (p ≤ 0.05)
was
significant found. On the other hand, upregulation in the expression
level of
P53, Bax, and caspase-3 genes (p ≤ 0.05). This study concluded that
curcumin
may be considered as a new saving candidate for the future progress of
antitumor agents. Nutrition and Wound Healing: An Overview Focusing on
the
Beneficial Effects of Curcumin International Journal of Molecular
Sciences,
July
2019
Anti-inflammatory and antioxidant properties of curcumin might reduce
the
expression of tumor necrosis factor alpha (TNF-α) and interleukin-1
(IL-1) and
restore the imbalance between reactive oxygen species (ROS) production
and
antioxidant activity. Since curcumin induces apoptosis of inflammatory
cells
during the early phase of wound healing, it could also accelerate the
healing
process by shortening the inflammatory phase. Moreover, curcumin might
facilitate collagen synthesis, fibroblasts migration, and
differentiation.
These Spices May Help In Regulating Blood Pressure NDTV, June
2019
The golden spice is celebrated for housing powerful antioxidant -
curcumin -
that protects against vascular dysfunction. It also protects arteries
of the
heart, which gets affected the most by high blood pressure. Consuming
turmeric
everyday can improve memory and happiness: Study Dunya News ,May
2019
Found in turmeric, curcumin is hailed as an anti-inflammatory with
antioxidant
properties, and it has also been suggested as a possible reason that
senior
citizens in India - where curcumin is somewhat of a staple - have lower
rates
of Alzheimer s disease and better cognitive performance. Published in
the
American Journal of Geriatric Psychiatry, the research conducted by the
University of California Los Angeles set out to examine the effects of
the
ingredient on people with mild, age-related memory loss. After
monitoring
curcumin levels in their blood and undergoing cognitive assessments and
PET
scans, the study found that those who took curcumin saw significant
improvement
in both memory and mood. In memory tests, the people taking curcumin
improved
by 28 percent over the 18 months and also showed mild improvement in
their
overall disposition. Curcumin ameliorates atherosclerosis Journal of
Cellular
Physiology, May
2019
The potential usage of curcumin in diverse human diseases has been
widely
studied, including arteriosclerosis (AS). We found that curcumin
treatment
significantly reduced HMECâ€1 cells viability, migration, and the
protein
levels of MMPâ€2, MMPâ€9, and vascular endothelial growth factor
(VEGF) in
the presence or absence of oxâ€LDL. Meanwhile, the expression of
VEGFR1 and
VEGFR2 was repressed by curcumin. miRâ€126 was upregulated by
curcumin. The
abovementioned effects of curcumin on HMECâ€1 cells were all
attenuated when
miRâ€126 was silenced. And also, VEGF was a target gene of miRâ€126,
and
curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling
pathways
via miRâ€126. The effects of curcumin and its regulation on miRâ€126
and VEGF
were confirmed in the animal model of AS. To sum up, curcumin exerted
potent
antiâ€AS property possibly via upregulating miRâ€126 and thereby
inhibiting
PI3K/AKT and JAK2/STAT5 signaling pathways. Curcumin and endometrial
carcinoma:
an old spice as a novel agent International Journal of Women's Health,
May
2019
The yellow Indian spice known as curcumin has been extolled for its
healing
powers and has recently been adopted for investigation by the
scientific
community as a potent anti-cancerous agent. Curcumin is a bright
yellow-colored
Indian spice derived from the herbaceous ginger plant turmeric, also
known as
Curcuma longa.18 This spice has been used for centuries to treat
numerous
diseases such as diabetes, atherosclerosis as well as liver,
rheumatoid, and
infectious diseases.18,19 Recent advances in molecular biology have
allowed a
more microscopic inspection into the active properties of this
pleiotropic
chemical (diferuloylmethane), which has proven to effectively interact
with
numerous signaling molecules within the body. Curcumin seems to show
antibacterial,20 anti-inflammatory,21 antioxidant,22 and antimicrobial
activities.23 In addition to all its benefits, curcumin also possesses
anti-cancerous effects by targeting several important players in cell
signaling
pathways such as p53,24 MAPKs, ERK, Ras,25 Wnt-β,26 PI3K, and Akt,27
all of
which play major roles in tumor progression. Furthermore, this herb, in
combination with other agents, is capable of disrupting the cell cycle
through
its effect on cellular apoptosis by activating caspases as well as
downregulating anti-apoptotic gene products (Bcl-X).28 Curcumin can
also
interact with several molecules involved in proliferation (EGFR and
AP-1),29,30
metastasis and invasion (MMP-9),31 angiogenesis (VEGF),32 and
inflammation
(NF-κB, COX-2, TNF, IL-1, IL-6, IL-2, IL-8, and IL-12, 5-LOX).33–35
Because
of its multivalent potential to target several molecules, this spice
can be
used on various types of cancers including colorectal, leukemia,
lymphoma,
breast, pancreatic, ovarian, head and neck, lung, prostate, and
melanoma.34 An
investigation into the available literature concerning curcumin as a
potential
therapy for cancers of the female reproductive system turned up with no
paper
studying the effect of curcumin on endometrial carcinoma. Therefore,
this
review is written to shed light and summarize any available data on the
effect
of curcumin as a promising therapeutic agent on this specific
gynecological
cancer. Curcumin induces cell death in human ovarian cancer Gynecologic
Oncology, May
2019
Curcumin (Cur), a yellow-colored dietary flavor from the plant (Curcuma
longa),
has been demonstrated to potentially resist diverse diseases, including
ovarian
cancer, but drug resistance becomes a major limitation of its success
clinically. The key molecule or mechanism associated with curcumin
resistance
in ovarian cancer still remains unclear. The aim of our study was to
investigate the effects of curcumin on autophagy in ovarian cancer
cells and
elucidate the underlying mechanism. Curcumin reduced cell viability and
induced
apoptotic cell death by MTT assay in human ovarian cancer cell lines
SK-OV-3
and A2780 significantly. Electron microscopy, western blot and
immunofluorescence staining proved that curcumin could induce
protective
autophagy. Curcumin can induce protective autophagy of human ovarian
cancer
cells by inhibiting the AKT/mTOR/p70S6K pathway, indicating the
synergistic
effects of curcumin and autophagy inhibition as a possible strategy to
overcome
the limits of current therapies in the eradication of epithelial
ovarian
cancer. Curcumin as Antipsychotic Treatment in Patients With Chronic
Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
Clinical
Neuropharmacology, May
2019
Curcumin is a natural polyphenol, which has a variety of
pharmacological
activities, including antioxidative and neuroprotective effects. The
studies
showed that curcumin improved the negative symptoms of schizophrenia.
There was
a significant response to curcumin within 6 months in total PANSS (P =
0.02)
and in the negative symptoms subscale (P = 0.04). The promising results
of
curcumin as an add-on to antipsychotics in the treatment of negative
symptoms
may open a new and safe therapeutic option for the management of
schizophrenia.
Curcumin exhibits an antiviral activity Antiviral Research, May
2019
Curcumin, a polyphenol, is the main bioactive compound in dietary spice
turmeric curcuma longa. It possesses anti-inflammatory, anti-oxidant
and
anti-neoplastic properties and shows potentials in treating or
preventing
particular diseases such as oxidative and inflammatory conditions,
metabolic
syndrome, arthritis, anxiety, hyperlipidemia and cancers. This
discovery
explains the wide range of effects of curcumin on diverse human
diseases and
predicts a potential application in treatment of viral infection and
virus-associated cancer. As a proof-of-concept, we demonstrated that
curcumin
is able to efficiently block Kaposi's sarcoma-associated herpesvirus
replication and inhibit the pathogenic processes of angiogenesis and
cell
invasion. An enzymatic assay confirmed that curcumin is an inhibitor of
APE1
redox function. Through inhibiting APE1 redox function, curcumin
prevents
c-jun/c-fos from binding to the AP-1 promoter. Through blocking AP-1
transcriptional activity, curcumin efficiently inhibits KSHV lytic DNA
replication and virion production. Curcumin also inhibits KSHV-mediated
pathogenesis including angiogenesis and cell invasion. Curcumin Can
Improve
Spinal Cord Injury Cellular and Molecular Neurobiology, May
2019
Curcumin exhibits potent anti-inflammatory and anti-oxidant properties.
Curcumin can play an important role in SCI recovery by inhibiting the
expression of NF-κB and TGF-β-SOX9. Herein, we review the potential
mechanism
of curcumin-inhibiting SOX9 signaling pathway in SCI treatment. The
inhibition
of NF-κB and SOX9 signaling pathway by curcumin has the potentiality
of
serving as neuronal regenerative mechanism following SCI. Effect of
combined
fish oil & Curcumin on murine skeletal muscle Nutrition Research,
May
2019
Nutritional supplements such as fish oil and curcumin enhance anabolic
signaling, glutathione levels, and heat shock proteins. We hypothesized
that
fish oil, rich in omega-3-fatty acids, combined with the polyphenol
curcumin
would enhance stress protective proteins and anabolic signaling in the
rat
soleus muscle, concomitant with synergistic protection of morphology.
C57BL/6
mice were assigned to 3 groups (n = 6/group): ambulatory controls
(CON),
hindlimb unloading (HU), and hindlimb unloading with 5% fish oil, 1%
curcumin
in diet (FOC). FOC treatments began 10 days prior to HU and tissues
were
harvested following 7 days of HU. FOC mitigated the unloading induced
decrease in CSA. FOC also enhanced abundance of HSP70 and anabolic
signaling
(Akt phosphorylation, p70S6K phosphorylation), while reducing Nox2, a
source of
oxidative stress. Therefore, we concluded that the combination of fish
oil and
curcumin prevents skeletal muscle atrophy due to a boost of heat shock
proteins
and anabolic signaling in an unloaded state. Curcumin reduces renal
damage
Federation of American Societies for Experimental Biology, May
2019
Treatment with curcumin initiated before or after rhabdomyolysis
induction
ameliorated all these pathologic and molecular alterations. In cultured
renal
tubular cells, myoglobin (Mb) induced ferroptosis-sensitive cell death
that was
also inhibited by curcumin. Mechanistic in vitro studies showed that
curcumin
reduced Mb-mediated inflammation and oxidative stress by inhibiting the
TLR4/NF-κB axis and activating the cytoprotective enzyme heme
oxygenase 1. Our
findings are the first to demonstrate the involvement of ferroptosis in
rhabdomyolysis-associated renal damage and its sensitivity to curcumin
treatment. Therefore, curcumin may be a potential therapeutic approach
for
patients with this syndrome. Curcumin induces apoptosis in
JAK2â€mutated cells
Journal of Cellular and Molecular Medicine, May
2019
Previous studies showed that curcumin, the active principle of the
Curcuma
longa, can suppress JAK2/STAT pathways in different type of cancer and
injuries. In this study, we investigated the antiâ€proliferative and
proâ€apoptotic effects of curcumin in JAK2 V617Fâ€mutated cells. HEL
cell
line and cells from patients JAK2 V617F mutated have been incubated
with
increasing concentrations of curcumin for different time. Apoptosis and
proliferation were evaluated. Subsequently, JAK2/STAT and AKT/mTOR
pathways
were investigated at both RNA and protein levels. We found that
curcumin
induces apoptosis and inhibition of proliferation in HEL cells.
Furthermore, we
showed that curcumin inhibits JAK2/STAT and mTORC1 pathways in JAK2
V617Fâ€mutated cells. This inhibition suggests that curcumin could
represent
an alternative strategy to be explored for the treatment of patients
with
myeloproliferative neoplasms. Curcumin: a potent agent to reverse
epithelial-to-mesenchymal transition Cellular Oncology, May
2019
Accumulating evidence indicates that curcumin, as a well-known
phytochemical,
can inhibit EMT/metastasis through various mechanisms and pathways in
human
tumors. Curcumin can exert chemo-preventive effects by inhibition and
reversal
of the EMT process through both TGF-β-dependent (e.g. in hepatoma and
retinal
pigment epithelial cancer) and -independent (e.g. in oral cancer,
colorectal
cancer, pancreatic cancer, hepatocellular carcinoma, breast cancer,
melanoma,
prostate cancer, bladder cancer, thyroid cancer and lung cancer)
pathways.
Curcumin can also mitigate chemoresistance through EMT suppression and
promotion of the antiproliferative effects of conventional
chemotherapeutics.
Therefore, curcumin has the potential to be used as a novel adjunctive
agent to
prevent tumor metastasis, which may at least partly be attributed to
its
hampering of the EMT process. The Brain And Memory Herbal Remedies
Home, May
2019
Curcumin has been linked to a lower dementia risk numerous times
before.
According to a
2009
study done by researchers from Duke University, it causes brain changes
and
reverses some of the effects of Alzheimer’s disease. Namely, it
targets the
amyloid plaques, which are considered to be one of the main causes of
brain
damage. The researcher Murali Doraiswamy said: “There is very solid
evidence
that curcumin binds to plaques, and basic research on animals
engineered to
produce human amyloid plaques has shown benefits. You can modify a
mouse so
that at about 12 months its brain is riddled with plaques. If you feed
this rat
a curcumin-rich diet, it dissolves these plaques. The same diet
prevented
younger mice from forming new plaques.†The active ingredient of
turmeric,
curcumin, is responsible for most of its medicinal and healing powers,
since it
is full of antioxidants and offers extremely powerful anti-inflammatory
properties. According to Dr. Josh Axe, DC, DMN, CNS: “Arguably, the
most
powerful aspect of curcumin is its ability to control inflammation. The
journal
Oncogene published the results of a study that evaluated several
anti-inflammatory compounds and found that aspirin and ibuprofen, two
of the
most common NSAIDs (non-steroidal anti-inflammatory drugs) are least
effective,
while curcumin is among the most effective anti-inflammatory compounds
in the
world. This news should have reached every household in the world after
the
study was conducted because inflammation is at the root of most
diseases.
Increasingly common diseases today — such as cancer, ulcerative
colitis,
arthritis, high cholesterol, and chronic pain — are all associated
with
inflammation. The anti-inflammatory effects of curcumin have also been
studied
as a possible treatment for Alzheimer’s disease. “ Moreover, this
amazing
spice improves health in a thousand other ways, cleanses the blood,
prevents
premature aging, detoxifies the liver, prevents free radical damage,
improves
skin health, and much more. Also, a series of
2013
studies done at the University of Tsukuba in Japan showed that curcumin
improved two measures of cardiovascular health as much as aerobic
exercise did.
Also, numerous studies have confirmed that turmeric and curcumin will
help you
soothe arthritis, reduce body fat, prevent cancer, and improve cancer
prognosis. Its anti-cancer activity has been studied and confirmed by
numerous
studies. Dr.Mercola reports: “ Curcumin actually has the most
evidence-based
literature supporting its use against cancer of any other nutrient,
including
vitamin D! As noted by Dr. William LaValley, curcumin is unique in that
it
appears to be universally useful for just about every type of cancer.
This is
odd, considering the fact that cancer consists of a wide variety of
different
molecular pathologies. One reason for this universal anti-cancer
proclivity is
curcumin’s ability to affect multiple molecular targets, via multiple
pathways. Once it gets into a cell, it affects more than 100 different
molecular pathways. And, as explained by Dr. LaValley, whether the
curcumin
molecule causes an increase in activity of a particular molecular
target, or
decrease/inhibition of activity, studies repeatedly show that the end
result is
a potent anti-cancer activity. Moreover, curcumin is non-toxic and does
not
adversely affect healthy cells, suggesting it selectively targets
cancer
cells—all of which are clear benefits in cancer treatment. Research
has even
shown that it works synergistically with certain chemotherapy drugs,
enhancing
the elimination of cancer cells.†Effects of Curcumin on Microglial
Cells
Neurotoxicity Research, May
2019
Curcumin is a phytochemical isolated from Curcuma longa. It is widely
used in
Asia and has many therapeutic properties, including antioxidant,
anti-viral,
anti-bacterial, anti-mutagenic, anti-amyloidogenic and
anti-inflammatory,
especially with respect to neuroinflammation and neurological disorders
(NDs).
Curcumin is a pleiotropic molecule that inhibits microglia
transformation,
inflammatory mediators and subsequent NDs. In this mini-review, we
discuss the
effects of curcumin on microglia and explore the underlying mechanisms.
Curcumin may help in some UC patients MDedge.com May
2019
Curcumin was evaluated in a multicenter trial showing that, when added
to
maximal mesalamine, it may be helpful in avoiding an advance in
therapy, with
54% achieving clinical remission at week 4 versus 0% of placebo-treated
patients. Likewise, curcumin has shown “minimal harm†in mild
ulcerative
colitis and may help nudge patients toward disease control without
having to
resort to corticosteroids or other immunosuppressive therapy, Dr. Brant
said.
Study highlights anti-tumor activity of curcumin on stomach cancer
Eureka
Alert, May
2019
Curcumin is widely used to impart color and flavor to food, but
scientists have
discovered that this yellow powder derived from the roots of the
turmeric plant
(Curcuma longa) can also help prevent or combat stomach cancer.
Curcumin
influences histone modifications primarily by inhibiting HATs and HDACs
to
suppress cancer cell proliferation and induce apoptosis (programmed
cell
death). Garcinol, whose chemical structure resembles that of curcumin,
inhibits
HATs and helps prevent stomach cancer by neutralizing free radicals.
Best
supplements for arthritis: Natural remedies to alleviate joint pain
Express,
May
2019
Turmeric contains a chemical called curcumin, which can reduce pain and
swelling by blocking inflammatory cytokines and enzymes. A clinical
trial using
a turmeric supplement in
2010
showed long-term improvement in pain and function in patients with
osteoarthritis of the knee, A small study in
2012
using a curcumin product also showed more reduced joint pain and
swelling in
patients with active rheumatoid arthritis, when compared to diclofenac
sodium.
Stop Different Types of Pain Trending Posts, May
2019
Curcumin to stop the pain caused by inflammation. Curcumin is a natural
proven
remedy well known for its anti-inflammatory properties. One of the most
popular
spices of Asia is Turmeric and it can be widely used in medicines
because its
components contain anti-inflammatory properties. Comparisons between
conventional medications and curcumin have been researched and it has
been
proved that curcumin is just as good as ibuprofen for relieving pain.
Turmeric
or curcumin capsules are being recommended by doctors for patients
suffering
from aches and sore joints. Curcumin combined with metformin decreases
glycemia
and dyslipidemia, and increases paraoxonase activity Diabetology &
Metabolic
Syndrome, May
2019
Curcumin, a yellow pigment isolated from Curcuma longa rhizomes, has
gained
attention due to its beneficial effects in controlling the disturbances
observed in diabetes mellitus. Treatment of diabetic rats with curcumin
or
metformin alone decreased the plasma levels of glucose,
triacylglycerol,
cholesterol, TBARS, and fluorescent AGEs, as well as increased the
activity of
PON 1. The combination of metformin with curcumin further decreased
dyslipidemia and TBARS levels in diabetic rats, indicating synergy, and
maintained the high levels of PON 1. These findings indicated that
curcumin
combined with metformin may act synergistically on dyslipidemia and
oxidative
stress, as well as increased PON 1 levels. Therefore, it might be a
promising
strategy for combating diabetic complications, mainly the
cardiovascular
events. The neuroprotective effects of curcumin Drug Design,
Development and
Therapy, May
2019
The beneficial, neuroprotective effects of curcumin against
ischemia-reperfusion injury have been demonstrated. In the present
study,
whether curcumin exerts neuroprotective effects associated with the
inhibition
of autophagy and hypoxia inducible factor-1α (HIF-1α) was
investigated. In
this study, curcumin decreased the death and apoptosis of cells, and
inhibited
autophagy and HIF-1α under OGD/R conditions, consistent with 3-MA
treatment or
HIF-1α downregulation. Moreover, inhibition of autophagy caused a
decrease in
HIF-1α, and the attenuation of HIF-1α induced autophagy suppression
under
OGD/R conditions. The results of this study showed that curcumin exerts
neuroprotective effects against ischemia-reperfusion, which is
associated with
the regulation of the reciprocal function between autophagy and
HIF-1α.
Curcumin supplementation mitigates NASH development Physiological
Reports, May
2019
Curcumin, a naturally occurring plant polyphenolic compound, may have
beneficial effects in nonalcoholic steatohepatitis (NASH) development.
Curcumin
treatment (12WD vs. 12WD+C) reduced (P < 0.05) hepatocellular
inflammation,
steatosis, NAFLD Activity Scores, and serum markers of liver injury
(AST, ALP).
Moreover, curcumin treatment also increased hepatic pACC/ACC, ApoB100,
and SOD1
protein, and decreased hepatic FGFâ€21 levels; whereas, curcumin
prevention
increased hepatic glutathione levels. Both curcumin prevention and
treatment
reduced molecular markers of hepatic fibrosis (Col1a1 mRNA) and
inflammation
(TNFâ€Î±, SPP1 mRNA). Curcumin supplementation beneficially altered
the NASH
phenotype in female Wistar rats, particularly the reversal of
hepatocellular
inflammation. The study identifies the possible therapeutic effects of
curcumin
on gastric cancer Onties.com May
2019
"We made a huge overview of the scientific literature on all nutrients
and
bioactive compounds with the potential to prevent or treat stomach
cancer and
found that curcumin is one of them," said Daniel Ciroz Calgano, a
professor at
UFPA. What Are Nootropics? Your Guide To The Best Brain-Boosting
Nutrients Mind
Body Green, May
2019
You may have 99 problems, but curcumin has probably already solved 98
of
them—and you can add improved cognitive performance to that list.
This
compound in turmeric has been shown to improve working memory with
consistent
long-term supplementation. Curcumin can also increase BDNF, reduce
oxidative
stress, and inhibit inflammatory cytokines. Daily dose of turmeric
could boost
memory, mood: study Pan Armenian, May
2019
Curcumin, the compound that gives the spice its rich dark yellow
colour, is
widely established to have anti-inflammatory and antioxidant
properties. The
research, published in the American Journal of Geriatric Psychiatry,
examined
the effects of curcumin on memory performance in people without
dementia, as
well as its impact on people already suffering from Alzheimer’s
disease.
“Exactly how curcumin exerts its effects is not certain, but it may
be due to
its ability to reduce brain inflammation, which has been linked to
both
Alzheimer’s disease and major depression,â€. Memory tests showed
that those
taking curcumin improved by 28 percent over the 18 months and
experienced mild
improvements in mood. "These results suggest that taking this
relatively safe
form of curcumin could provide meaningful cognitive benefits over the
years,â€
said Dr Small. Study reveals turmeric is more effective at killing
cancer cells
than chemo or radiation El Reportero, May
2019
One aspect of curcumin’s intelligent approach is its ability to
downregulate
interleukin-6. The over-expression of this cytokine has been linked to
inflammation progressing to cancer, and curcumin stops it from being
released
and stimulating cancer stem cells. It also directly and indirectly
downregulates interleukin-1, which plays a vital role in the growth of
cancer
cells, and interleukin-8, which stimulates the regrowth of
tumor-forming cancer
stem cells. Another way curcumin can fight cancer is by decreasing the
binding
of CXCR1 and CXCR2 and modulating pathways like the Wnt Signaling
Pathway, the
Notch Pathway, the FAK/AKT/FOXo3A Pathway, and the Hedgehog Pathways.
If those
terms are unfamiliar to you, you’re not alone – cancer is a
complicated
disease, but the bottom line is that curcumin targets deadly cancer
stem cells
in eight different and very powerful ways. Curcumin is a very efficient
cancer
fighter, targeting the most dangerous cells of all, cancer stem cells,
without
touching normal cells. Contrast this with chemotherapy, which damages
the DNA
of quickly-replicating cells while they’re vulnerable during the
mitosis
stage of cell division. It does this without determining if the cells
are
cancerous or completely healthy. Healthy Options: Root Plants And
Herbal Leaves
For Stress And Anxiety Management TG Daily, May
2019
Turmeric root, on the other hand, also has very promising benefits for
the
effective management of stress and anxiety disorders. Both animal
studies and
human studies conclude that the oral intake of curcumin can
significantly
prevent anxiety-like behavior and improve mobility. Study: Curcumin,
Resveratrol Possible Anti-Cancer Compounds Whole Foods Magazine, May
2019
Curcumin can play a role in preventing stomach cancer, according to a
new study
from researchers at the Federal University of São Paulo (UNIFESP) and
the
Federal University of Pará (UFPA). High blood pressure - best spices
to
prevent deadly hypertension symptoms Express, May
2019
Turmeric’s active ingredient, curcumin, could play a role in lowering
blood
pressure, according to cardiologist Dr Stephen Sinatra.Curcumin is a
powerful
antioxidant the helps to break-up big clumps of platelets in the blood,
he
said. If you’d prefer to take curcumin as a supplement, aim for
around 500mg
in a single day. ou may not have heard of curcumin before, but you have
probably heard of turmeric, the spice that is best known as an
ingredient in
Indian curry and yellow mustard. Turmeric has been my number one
natural blood
pressure reducer and cardiovascular spice for years, and its yellow
colour
comes from curcumin — a powerful antioxidant and anti-inflammatory
compound
that’s been found to reduce blood pressure by lowering the excess
platelet
aggregation that occurs in sticky, clot-forming blood. Is the Curcumin
in
Turmeric More Effective Than Prozac for Depression? Tmd.org May
2019
Curcumin is the main compound in the spice, turmeric. This spice is
known for
its bright yellow or orange color, flavorful taste, and is a great
addition to
curries. It is also well known in traditional medicine for its healing
properties and has been used for centuries to heal many conditions.
Curcumin
possesses both anti-inflammatory and antioxidant properties. Beyond
fighting
common inflammatory-related conditions, such as arthritis and cancer,
curcumin
has been researched for its potential role in treating depression. One
study
found that curcumin therapy successfully reduces depressive symptoms
when
compared to the leading antidepressant medication, Prozac. What set
curcumin
apart was the fact that little to no side effects were reported.
Antidepressants can cause any number of side effects including nausea,
vomiting, blood pressure changes, dizziness, anxiety, and weight gain.
With
curcumin being more natural, these side effects can be avoided, and the
depression itself can be successfully treated. Studies continue to
research the
effectiveness of curcumin on depression. With all this said,
antidepressant
medication is still preferred for good reasons, and these should be
discussed
with your physician. Do not stop taking prescribed medication before
consulting
with your doctor. The Natural Approach to Fighting Depression Curcumin
is a
strong antioxidant which means it scavenges and rids the body of
harmful free
radicals. The reduction of oxidative damage also reduces inflammation,
and this
can alleviate depressive symptoms. Studies have found a link between
inflammation and depression but are not entirely which is the cause and
which
the result. The relationship does, however, tell us that by reducing
inflammation, you can also reduce the symptoms of depression.
Depression has
also been scientifically linked to reduced production of BDNF
(brain-derived
neurotrophic factor), a growth hormone that impacts the function of
your brain.
Curcumin increases the presence of BDNF in the brain, which can lead to
a
reduction is depressive symptoms or a reduced risk of developing the
disease.
Curcumin has also been linked to increased production of the
neurotransmitters
serotonin and dopamine. Anxiety is another common mental disease that
exists
alongside depression in many cases. Curcumin has been found to increase
the
production of DHA, an essential omega-3 fatty acid. Deficiency in this
omega-3
has been linked to increased anxiety, which can trigger or cause
depression. By
reducing anxious thoughts or behaviors, curcumin can also help reduce
depression. Why you should be adding turmeric daily to your life
Mustafa Mehar,
May
2019
There have been over 50 clinical trials done on the health benefits of
turmeric
and curcumin and it seems there are only more coming our way. Below is a
summary of some of the studies and their claims. The major health
benefits of
Turmeric 1. It plays a major role in cancer prevention, including
myeloma,
pancreatic, colon, breast, brain, blood, kidney, liver, pancreas and
skin
cancer. This is due to the fact that it can help prevent the initial
processes
that lead to mutations within our DNA. 2. It has major
anti-inflammatory
effects, according to a study which researched the efficacy of curcumin
in the
treatment for rheumatoid arthritis. It has been found to treat other
inflammatory conditions effectively as well. 3. Turmeric plays a
preventative
role in the development of multiple diseases, such as lung disease and
brain
disease, and has been found to improve brain function. 4. It is
beneficial for
your cardiovascular health, supplementing daily with turmeric has been
found to
have as many benefits in improving our cell function in the arteries as
one
hour of aerobic exercise. 5. It is believed that turmeric may play a
role in
preventing Alzheimers disease. This condition is related to a build up
of
Amyloid-Plaques in the brain, and curcumin has been found to aid in
removing
these build ups. 6. Curcumin acts as a natural anti-depressant, where
studies
show it increases the brain’s serotonin and dopamine levels, as well
as
increasing brain-derived neurotrophic factor levels (BDNF). Low levels
of BDNF
has been associated with depression. 7. It offers anti-aging benefits.
Oxidation and inflammation within the body are linked to aging and
curcumin, a
powerful anti-oxidant, potentially preventing these processes from
occurring
within the body. 8. Turmeric may also benefit your skin. The
anti-inflammatory
and antioxidant properties can aid with skin health, such as eczema or
psoriasis. Protective effects of curcumin in embryonic fibroblast cells
Journal
of Biochemical and Molecular Toxicology, May
2019
The study indicated that curcumin might be a potential ameliorative
antioxidant
to protect the fibroblast cell toxicity induced by sodium arsenite.
Revealing
the Effects of Curcumin on SH-SY5Y Neuronal Cells: A Combined Study
from
Cellular Viability, Morphology, and Biomechanics Journal of
Agricultural and
Food Chemistry, May
2019
The present study provides insights into the effects of curcumin on
neuronal
cells from both biological and biophysical aspects, which can help more
comprehensively understand the interactions between curcumin and
SH-SY5Y cells.
Safety and efficacy of curcumin versus diclofenac in knee
osteoarthritis: a
randomized open-label parallel-arm study Trials, May
2019
At days 14 and 28, patients receiving curcumin showed similar
improvement in
severity of pain and KOOS scale when compared with diclofenac, and the
difference was not statistically significant. At day 7, the patients
who
received curcumin experienced a significantly greater reduction in the
number
of episodes of flatulence compared with diclofenac (P <0.01). At day
28, a
weight-lowering effect (P <0.01) and anti-ulcer effect (P <0.01)
of curcumin
were observed. None of the patients required H2 blockers in the
curcumin group,
and 19 patients required H2 blockers in the diclofenac group (0% versus
28%,
respectively; P <0.01). Adverse effects were significantly less in
the curcumin
group (13% versus 38% in the diclofenac group; P <0.01). Patient’s
and
physician’s global assessment of therapy was similar in the two
treatment
groups. Curcumin has similar efficacy to diclofenac but demonstrated
better
tolerance among patients with knee OA. Curcumin can be an alternative
treatment
option in the patients with knee OA who are intolerant to the side
effects of
non-steroidal anti-inflammatory drugs. How Curcumin Can Help with
Memory and
Conditions Like Dementia and Alzheimer’s Life News, May
2019
The most beneficial compound found in turmeric is curcumin, and it can
help
support memory functions and contribute to a feeling of calmness and
bring
relief from mental stress or strain. It has also been shown to lessen
fatigue
as well as promote better heart health. Curcumin is also known to
contribute to
the increase of BDNF (a brain hormone), which then enhances the
function of the
brain’s neurons, encouraging growth and promoting strength. Also, one
of the
features of diseases such as dementia and Alzheimer’s is the buildup
of
amyloid-beta proteins or plaque. In some studies, curcumin was found to
have
the potential to obstruct the development of this plaque. The major
health
benefits of Turmeric Power Living, May
2019
Curcumin has major anti-inflammatory effects, according to a study
which
researched the efficacy of curcumin in the treatment for rheumatoid
arthritis.
It has been found to treat other inflammatory conditions effectively as
well.
It is beneficial for your cardiovascular health, supplementing daily
with
turmeric has been found to have as many benefits in improving our cell
function
in the arteries as one hour of aerobic exercise. It is believed that
turmeric
may play a role in preventing Alzheimers disease. This condition is
related to
a build up of Amyloid-Plaques in the brain, and curcumin has been found
to aid
in removing these build ups. Curcumin acts as a natural
anti-depressant, where
studies show it increases the brain’s serotonin and dopamine levels,
as well
as increasing brain-derived neurotrophic factor levels (BDNF). Low
levels of
BDNF has been associated with depression. It offers anti-aging
benefits.
Oxidation and inflammation within the body are linked to aging and
curcumin, a
powerful anti-oxidant, potentially preventing these processes from
occurring
within the body. Remedies To Help Reduce Inflammation Romper, May
2019
It's almost impossible to look at inflammatory remedies without
mentioning this
particular spice. "Turmeric has been used in India for thousands of
years as a
medicinal herb," says LA-based naturopath Dr. Saman Faramarzi. As it
turns out,
turmeric contains curcumin, which has anti-oxidant and
anti-inflammatory
properties, according to Foods. If you want to give this spice a try,
then
making turmeric milk (AKA golden milk) at home is a simple
introduction,
according to Elite Daily. The Golden Spice: 5 Incredible Haldi Benefits
That
Would Take You By Surprise NDTV, May
2019
Curcumin with its amazing anti-inflammatory abilities helps suppress
chronic
inflammation. Scientific research has shown a positive co-relation
between
curcumin and weight loss by preventing the growth of fat cells and it
also
protects against the negative impact of obesity on our health. Curcumin
has
been documented to improve insulin sensitivity, reducing elevated BP,
and
controlling triglyceride and cholesterol levels while improving HDL
cholesterol. Antioxidant and anti-inflammatory activity of curcumin is
the main
reason of the health benefits of turmeric. It has been shown to reduce
oxidative stress and increase the activity of our body's antioxidants.
Curcumin
has been found to have the strongest antioxidant effects when compared
with
other compounds. Prevent Autoimmune Diseases Medical Daily, May
2019
People are obsessed with turmeric supplements to fight pain and
inflammation.
Scientific evidence shows that curcumin, a pigment from turmeric root,
regulates your immune system’s health and suppresses autoimmune
diseases.
Anti-inflammatory foods that reduce pain Baltimore Post Examiner, May
2019
Turmeric has a compound known as curcumin which has been found to be as
effective as anti-inflammatory medications. Curcumin has powerful
anti-inflammatory effects and antioxidants. It’s a better alternative
because
it has no side effects like the medication itself. Best supplements for
diabetes Express, May
2019
Turmeric’s active ingredient, curcumin, could help to reduce insulin
resistance, and subsequently protect against diabetes, said registered
nurse
David Spero. It improves insulin function, which allows more insulin to
get
into cells, he claimed. Adding turmeric to your diet could also lower
your
cholesterol and even prevent some types of cancer, added the nurse.
“One
diabetes medicine may lower blood sugar and cholesterol, protect your
eyes and
kidneys, relieve pain, prevent cancer, and improve your sex life. It
also
tastes good,†Spero wrote on Diabetes Self-Management. “This
medicine is
turmeric, made from the root Curcuma longa, a member of the ginger
family.
“Curcumin may also help treat aspects of diabetes, both type 1 and
type 2.
Best supplements for arthritis Expess, May
2019
Turmeric contains a chemical called curcumin, which can reduce pain and
swelling by blocking inflammatory cytokines and enzymes. A clinical
trial using
a turmeric supplement in
2010
showed long-term improvement in pain and function in patients with
osteoarthritis of the knee, A small study in
2012
using a curcumin product also showed more reduced joint pain and
swelling in
patients with active rheumatoid arthritis, when compared to diclofenac
sodium.
Foods that Help Anxiety Care2, May
2019
Turmeric has been shown in numerous studies to soothe both depression
and
anxiety. Not only do turmeric’s powerful phytochemicals do a stellar
job of
counteracting inflammation, but turmeric can help balance the
chronically
activated stress response that is associated with anxiety. Supplements
of
curcumin extract will be the most therapeutic source, but it definitely
doesn’t hurt to enjoy a golden latte once in a while, either. The One
Supplement That Will Take Your Recovery To The Next Level Mind Body
Green, May
2019
Turmeric has proven its weight in (literal) gold with regards to
fighting
inflammation. That’s because its active compound, curcumin, is
anti-inflammatory and has many preventative health benefits. And given
that the
root cause of many diseases is inflammation, turmeric has risen in
popularity
in both its whole, ground, and supplement form. Reasons to Add Turmeric
to Your
Diet IBC News, May
2019
Turmeric can help you reduce inflammation. The presence of curcumin in
turmeric
makes it a good remedy to fight inflammation. It is extremely good for
arthritis patients. It can help arthritis patients treat inflammation
naturally. There are several risk factors which can contribute to
cancer.
Various studies indicate that curcumin can reduce the growth of
cancerous
cells. According to the studies, turmeric consumption can help you
reduce the
risk of pancreatic cancer, prostate cancer and many others. Curcumin
can also
stimulate brain function and improve memory. According to studies,
turmeric can
help you boost brain power. It can also reduce the risk of
Alzheimer’s
disease and depression. It will also stimulate logical thinking. More
muscles
in old age thanks to curcumin supplementation Ergo-Log.com, April
2019
More muscles in old age thanks to curcumin supplementation. As you get
older,
your body loses more and more muscle mass. Initially the decay of your
muscles
is so slow that you hardly notice it, but every year the decay process
runs a
little faster than the year before. Supplementation with curcumin, the
most
important bioactive substance in turmeric, can block this process. This
is
evident from an animal study that will shortly appear in the
International
Journal of Molecular Sciences. Natural food for the prevention of
cancer The
Indian Talks, April
2019
Curcumin is a component of turmeric. Studies in mice have shown that
curcumin
prevents the occurrence of tumors caused by various carcinogenic
factors.
Angiogenesis is the process of forming capillaries. In the case of a
cancer
that may have occurred due to earlier DNA damage, it is a process that
makes it
possible to feed the cancer so that it can develop. In this way,
micro-gas is
transformed into a cancer capable of growing and attacking tissues. The
purpose
of curcumin is to inhibit the formation of new blood vessels that feed
the
cancer, depriving it of the possibility of taking nutrients and
developing
cancer. Turmeric outperforms chemotherapies in treating cancer Reports
Health
Care, April
2019
Curcumin is one of the active compounds in turmeric. It is responsible
for most
of the health-promoting effects offered by the spice. Curcumin,
reportedly,
benefits conditions like obesity, diabetes, cardiovascular diseases,
neurological issues, cancer, and other chronic, inflammatory diseases.
One
research team analyzed a total of 19 test tube and five animal studies.
They
evaluated the ability of turmeric extracts to fight or prevent
glioblastoma.
The researchers found that curcumin inhibits the growth of cancer cells
and
induce cell death in certain subpopulations of glioblastoma tumors.
Thus, it
can serve as a potent therapeutic agent for treating cancer. The other
study
was published in the journal Nutrition and Cancer. It discovered the
possibility to get a bioactive dose of curcumin into human glioblastoma
cancer
cells via oral delivery methods. Four days before surgical removal of
brain
tumors, the human volunteers for the study were given 70 milligrams of a
curcuminoid combination three times in a day. During the surgery tumor
and
blood samples were collected for analyzing the curcuminoid
concentrations. The
tumors were found to have detectable levels of curcuminoids. This made
the
researchers conclude that oral treatments alter the energy metabolism
of
tumors. Many other studies also reveal the potent anti-cancer
properties of
curcumin. However, curcumin extracts are still not being used in cancer
therapy. Researchers suggest the pharmaceutical industries to make use
of this
wonder spice for treating cancer. It can serve as a convenient, natural
and
safe treatment for the condition. How To Use Turmeric To Fight Diabetes
Post
News, April
2019
Hundreds of studies have been conducted on curcumin (the most important
component of turmeric) and its effects on diabetes. The results about
using
turmeric for diabetes have been extremely encouraging. In this post, we
talk
about everything you possibly need to know about turmeric and turmeric
for
diabetes can be helpful. The curcumin in turmeric has been credited
with most
of its anti-diabetic effects. It was found to lower blood glucose
levels and
even fight inflammation – which is one severe effect of diabetes. One
2013
study conducted by the Beijing University of Chinese Medicine showed
how
curcumin could lower the glucose levels and help improve other
diabetes-related
conditions . Even turmeric extracts (often found in pharmacies) were
found to
make diabetes more manageable. And they also prevented other
diabetes-related
complications like nerve damage and cataracts. Protective effects of
amifostine, curcumin, and melatonin against cisplatin-induced acute
kidney
injury Naunyn-Schmiedeberg's Archives of Pharmacology, April
2019
Amifostine, curcumin, and melatonin reduced the increases in serum urea
and
serum creatinine levels following cisplatin administration and reduced
the
levels of TNS, HPS, NF-κB/p65, 8-OHdG, and caspase-3 expressions
(p < 0.05). ROS-scavenging antioxidants may be a promising means
of
preventing acute kidney disease in patients using cisplatin in the
treatment of
malignant tumors. Nutrition: Get the protective power of phytonutrients
Duluth
News Tribune, April
2019
Curcuminoids are phytonutrients found in turmeric root, which is a
spice
traditionally used in Indian cuisine. Curcumin offers anti-inflammatory
benefits and may help prevent or treat colorectal cancer. Health
Benefits of
Turmeric Akhabar News, April
2019
Turmeric contains curcumin, a substance with powerful anti-inflammatory
and
antioxidant properties. Most studies used turmeric extracts that are
standardized to include large amounts of curcumin. Chronic inflammation
contributes to many common Western diseases. Curcumin can suppress many
molecules known to play major roles in inflammation. Curcumin has
powerful
antioxidant effects. It neutralizes free radicals on its own but also
stimulates your body’s own antioxidant enzymes. Curcumin boosts
levels of the
brain hormone BDNF, which increases the growth of new neurons and
fights
various degenerative processes in your brain. Curcumin leads to several
changes
on the molecular level that may help prevent and perhaps even treat
cancer. Due
to its many positive health effects, such as the potential to prevent
heart
disease, Alzheimer’s and cancer, curcumin may aid longevity. Herbs
& spices
with the most powerful health benefits New Times, April
2019
First and foremost, turmeric is an incredible inflammation fighter. It
can even
make a significant difference in individuals who suffer from rheumatic
pain.
This is because of constituent curcumin – its active constituent and
yellow
bioactive compound, lending turmeric its colour. Curcumin has a wide
variety of
biological interactions when consumed. Its anti-inflammatory benefits
make it a
good choice for healing leaky gut, improving digestion, and addressing
autoimmune issues with inflammatory side effects. Due to curcumin’s
anti-inflammatory properties, it has the ability to slow down
inflammation-related ageing processes and diseases. Curcumin is also
effective
at increasing antioxidant capacity in the body. It’s one of the most
concentrated antioxidant foods you can consume! This means an overall
reduction
of oxidative stress. Finally, curcumin can increase immunity with its
antibacterial and anti-viral properties, protect against cancer and the
development of tumours, and improve heart health. Here's How Turmeric
Could
Help Keep Inflammation At Bay NDTV, April
2019
"Curcumin has a medicinal effect comparable to drugs, such as
hydrocortisone
and phenylbutazone, and can be used to provide relief from rheumatoid
arthritis, treat inflammatory bowel disease, protect against diabetes,
and even
avoid heart disease and stroke by preventing the build-up of plaque in
the
arteries," notes the book 'Healing Foods'. Super foods every woman
should
include in her diet The Hans India, April
2019
Turmeric may be the most effective nutritional supplement in existence.
Many
high-quality studies show that it has major benefits for your body and
brain.
Curcumin, a plant nutrient that gives turmeric its deep golden hue, has
long
been used in Eastern medicine to treat infections and help speed wound
healing.
Turmeric: This must-have spice found in your kitchen is full of
benefits Times
of India, April
2019
Turmeric comes from the root of Curcuma longa, a plant of the ginger
family and
contains compounds with medicinal properties. These compounds are
called
curcuminoids, the most important of which is curcumin. Numerous studies
suggest
that this spice is beneficial for both body and brain. Foods to keep
your
brain, memory sharp Daily Sabah, April
2019
Turmeric: With its active ingredient curcumin, turmeric is a strong yet
natural
antioxidant. This plant, which has been used for its medical benefits
throughout history, helps your brain receive more oxygen, learn and
process
information easier. Effects of turmeric and curcumin on oral mucositis:
A
systematic review Phytotherapy Research, April
2019
The aim of this study was to evaluate the effects of turmeric and
curcumin in
the management of oral mucositis in cancer patients undergoing chemo
and/or
radiotherapy. Patients treated with turmeric/curcumin experienced
reduced grade
of mucositis, pain, erythema intensity, and ulcerative area. Current
evidence
suggests that topical application of turmeric or curcumin is effective
in
controlling signs and symptoms of oral mucositis. Thus, further
investigation
is required to confirm the promising effect of turmeric and curcumin in
oral
inflammatory lesions. Effects of Prolonged Dietary Curcumin Exposure on
Skeletal Muscle International Journal of Molecular Sciences, April
2019
Curcumin is a phenolic compound shown to upregulate antioxidant
defenses and
directly quench RONS in vivo. Consumption of curcumin coupled with
reduced food
intake imparted beneficial effects on aged skeletal muscle. The benefit
of
curcumin on aging skeletal muscle should be explored further. Curcumin
and
tetrahydrocurcumin induce cell death in Araâ€Câ€resistant acute
myeloid
leukemia Phytotherapy Research, April
2019
The effective use of curcumin as an anticancer agent has been
demonstrated in
clinical trials. Tetrahydrocurcumin, a major curcumin metabolite,
exhibits
pharmacological activities similar to those of curcumin. Curcumin
induces cell
death mainly through the apoptosis pathway, and tetrahydrocurcumin
induces cell
death mainly via an autophagy pathway in HL60 cells. The results
demonstrated
that curcumin and tetrahydrocurcumin induced cell death by apoptosis
and
autophagy, respectively, in Araâ€Câ€resistant HL60 cells. Thus,
curcumin and
tetrahydrocurcumin have potential applications in the treatment of
acute
myeloid leukemia with Araâ€C resistance. Curcumin inhibits the
proliferation
and invasion of MG-63 cells OncoTargets and Therapy, April
2019
The aims of this study were to determine the effect of curcumin on
osteosarcoma
(OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and
evaluate the
prognostic value of this pathway in OS. Curcumin-mediated inhibition of
the
proliferation and migration of MG-63 cells was associated with
inactivation of
JAK/STAT signaling. Dietary curcumin enhances intestinal antioxidant
capacity
Poultry Science, April
2019
The study investigated the effects of dietary curcumin supplementation
on
tissue distribution of curcumin and its metabolites, intestinal
antioxidant
capacity, and expression of detoxification-related genes in ducks. In
conclusion, dietary supplementation with 200 to 800 mg/kg curcumin
enhanced the
accumulation of curcumin and its metabolites in jejunum as well as
increasing
the antioxidant capacity and detoxification potential, which play major
roles
in the protection of duck intestines against damage. Histopathological
and
biochemical studies on the effect of curcumin and taurine against
bisphenol A
toxicity Environmental Science and Pollution Research, April
2019
Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. In
the
present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA,
and
taurine plus BPA were exposed to rats for 4 weeks via gavage. Content
of
malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD,
CAT) and
also histopathological and cytopathological changes of heart were
studied. No
significant changes in all studied parameters were seen between
control, olive
oil, curcumin, and taurine-treated groups. However, there were
significant
differences in levels of malondialdehyde and activities of antioxidant
enzymes
in BPA-exposed rats and some histo/cytopathological changes determined.
In
curcumin plus BPA-exposed and taurine plus BPA-exposed groups, we
measured the
preventive effects on some parameters but not exactly. As a result,
curcumin
and taurine significantly minimized BPA-induced cardiotoxicity in rats.
Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in
the
Nervous System Molecular Neurobiology, March
2019
Curcumin, an active ingredient of turmeric, can affect all these
pathways and
exert neuroprotective activity culminating in the amelioration of I/R
injury in
the nervous system. In this review, we discuss the protective effects
of
curcumin against I/R injury in the nervous system and highlight the
studies
that have linked biological functions of curcumin and I/R injury
improvement.
Top 5 Benefits of Turmeric for your Health The Frisky, March
2019
Curcumin, a recognized anti-inflammatory, is the main component of
turmeric.
Curcumin is said to be as effective as drugstore anti-inflammatories
like
ibuprofen and aspirin. Curcumin present in turmeric boosts the body’s
metabolism, reduces stress as an adaptogen, and enhances weight loss.
All these
factors combined increase the levels of good cholesterol in the body,
and
decrease the effects of bad cholesterol. It also helps in keeping blood
sugar
levels in check by stabilizing the glucose levels in the body. Curcumin
boosts
the production of a protein called BDNF, which is vital to the health
of the
brain. High BDNF levels generally result in better memory and mood.
Curcumin
ameliorated myocardial infarction by inhibition of cardiotoxicity in
the rat
model Journal of Cellular Biochemistry, March
2019
Curcumin is touted as a polyphenol phytocompound with appropriate
cardioprotective properties. Curcumin was found to reduce oxidative
status by
reducing SOD and MDA contents ( P < 0.05). Gross and microscopic
examinations revealed that the decrease of infarct area, inflammation
response
and collagen deposition in rats given ISO plus curcumin (
P < 0.05). We
noted the superior effect of curcumin to reduce the number of apoptotic
cardiomyocytes after 9 days. Data point the cardioprotective effect of
curcumin
to diminish the complication of infarction by the reduction of cell
necrosis
and apoptosis in a rat model of experimental infarction. How to Stop
Suffering
from Chemo Brain Care2, March
2019
The yellow-colored compound found in the curry ingredient turmeric,
known as
curcumin, offers more than delicious taste. It is a well-established
brain-healer and memory booster. In a study published in the Journal of
Psychopharmacology researchers found that in just one hour after taking
curcumin supplements, study participants showed significant performance
improvement on memory and attention tasks compared to the placebo
group.
Ideally choose a standardized extract of curcumin. I usually recommend
400 mg
of curcumin three times daily for people suffering from brain
disorders.
Curcumin reduces development of seizurelike events Journal of Cellular
Biochemistry, March
2019
The percentage of recorded CA1 neurons displaying SLEs was lower in
curcuminâ€treated slice cultures compared to vehicleâ€treated slices
(25.8%
vs 72.5%), whereas rapamycin did not reduce SLE occurrence
significantly (52%).
Western blot for phosphorylatedâ€S6 (pS6) and phosphorylated S6K
confirmed
that rapamycin inhibited the mTOR pathway, whereas curcumin only
lowered pS6
expression at one phosphorylation site. Realâ€time quantitative
polymerase
chain reaction results indicated a trend toward lower expression of
inflammatory markers ILâ€1β and ILâ€6 and transforming growth factor
β
after 3 weeks of treatment with rapamycin and curcumin compared to
vehicle. Our
results show that curcumin suppresses SLEs in the combined
hippocampalâ€entorhinal cortex slice culture model and suggest that
its
antiepileptogenic effects should be further investigated in
experimental models
of TLE. Which herbs help reduce inflammation? Granite Gazette, March
2019
Turmeric typically comes in the form of a yellow powder from the root
of the
turmeric plant. It contains a chemical called curcumin, which may have
anti-inflammatory properties. Several have shown that turmeric can help
reduce
inflammation and discomfort in people with . It works by limiting the
production of molecules called cytokines, which cause inflammation.
Researchers
continue to how curcumin affects inflammation in a range of other
conditions,
such as inflammatory bowel disease. Curcumin has the evidence base for
its
anti-inflammatory effects compared with other herbal remedies. Effects
of
curcumin on hypoxia-inducible factor Pharmacological Research Journal,
March
2019
A growing body of evidence indicates that curcumin, a natural bioactive
compound of turmeric root, significantly targets both HIF-1 subunits,
but is
more potent against HIF-1α. In this review, we have summarized the
knowledge
about the pharmacological effects of curcumin on HIF-1 and the related
molecular mechanisms that may be effective candidates for the
development of
multi-targeted therapy for several human diseases. Foods to unclog
arteries
Femina, March
2019
While the anti-cancer benefits of turmeric have been well-documented,
the key
ingredient curcumin is also beneficial to heart health. This is
primarily
because of its anti-inflammatory benefits, which directly impacts
arterial
health, reducing the damage to arterial walls. Vitamin B6 can control
damage
caused to blood vessels. Turmeric: A Secret Weapon to Lose Weight &
Keep It Off
Dr. Cesar Lara, March
2019
Curcumin appears to modulate several cellular pathways that contribute
to this
ongoing, damaging process. Indeed, curcumin's anti-obesity effects may
be in
part due to its inflammation-reducing properties. One additional
relevant
mechanism of action not discussed in this study is curcumin's capacity
to cause
programmed cell death in white fat cells. This may contribute to
decreasing the
overall ability of the body to store unhealthy fat. Curcumin's Health
Benefits
Given the research above and the plethora of studies on distinct health
conditions, it would be unethical not to use curcumin. Its safety
profile is
documented, and it has been time-tested for thousands of years in a
wide range
of cultures. In fact, curcumin has shown to be at least as effective
for
depression(8) as the antidepressant Prozac and is capable of preventing
the
progression of prediabetes to diabetes. It is also known to strengthen
and
improve your digestion(9) and support healthy liver function. Which
Type of
Curcumin (Turmeric Extract) is Best? When cooking, choose a pure
turmeric
powder rather than a curry powder. The curry powder may contain very
little
curcumin when compared to turmeric. You can also take curcumin in
supplement
form, which is a more convenient method to achieve the dosage needed
for the
health benefits discussed above. Protective effects of curcumin on
radioiodineâ€induced salivary gland dysfunction in mice Journal of
Tissue
Engineering and Regenerative Medicine, March
2019
Curcumin and RI + amifostine groups showed evidence of tissue
remodeling, with
a greater number of salivary epithelial cells (AQPâ€5â€positive), SG
ductal
cells (CK18â€positive), endothelial cells (CD31â€positive), and
myoepithelial
cells (αâ€SMAâ€positive). RI + curcumin and RI + amifostine groups
alleviated RIâ€induced cell death, demonstrating antiâ€apoptotic
effect,
compared to the RI group. Both SOD activity and the protein expression
levels
of SOD2 were higher in the RI + curcumin and RI + amifostine groups
than in the
RI group. Our results demonstrate that curcumin ameliorates
RIâ€induced SG
dysfunction in mice. Top 5 Health Benefits Of Turmeric And Its
Compounds You
Need To Know NB Post Gazette, March
2019
Turmeric has anti-inflammatory properties because of the compound
Curcumin.
Moreover, it helps in cutting out all the bacterial infection that has
covered
the wound. Curcumin can effectively cure and improve endothelium.
Moreover,
oxidation and inflammation is a major partner of heart diseases. As
mentioned
earlier, this spice has compounds which have anti-inflammatory and
antioxidative properties. 'Golden Elixir" made from turmeric Press
Republican,
March
2019
Turmeric and especially its most active compound curcumin have many
scientifically-proven health benefits, such as the potential to prevent
heart
disease, Alzheimer’s and cancer, according to a July 13,
2018
article on www.healthline.com It’s a potent anti-inflammatory and
antioxidant
and may also help improve symptoms of depression and arthritis.
Anti-Inflammatory Herbs Care2, March
2019
If you’re thinking that turmeric seems to be good for just about
everything,
you’d be right. That’s because the curry ingredient contains a
potent
anti-inflammatory known as curcumin. In a study published in the
Journal of
Biological Chemistry researchers found that curcumin improved the
healing of
tendonitis, which involves inflammation of the tendons that help
maintain our
body’s structural integrity. Advantages of Curcumin Most Inside,
March
2019
Curcumin is a naturally occurring antioxidant abundantly found in the
popular
spice turmeric that has been used since ages in cooking and Ayurvedic
medicines
for its incredible health benefits. Turmeric holds a pious place in
Ayurvedic
medicine and is applied on cuts and burns due to its anti-septic
properties.
Turmeric milk is extensively consumed in India as turmeric is studied
to cure
gastrointestinal discomfort, respiratory issues and helps in treating
various
bodily disorders. The Indian food culture places peculiar importance
for spices
and it is mainly used for making curry dishes as it renders distinct
colour,
flavour and nutrition to the food. Being such a valued spice on the
health
front, people across the world now understand the health benefits of
Curcumin.
Various medical researchers worldwide have investigated on how
consuming
turmeric or curcumin supplements can alleviate various health issues.
Know your
mesonutrients Times of India, March
2019
The world has recognised the medicinal use of curcumin and now curcumin
milk,
also known as turmeric latte, and it is part of café menus
internationally.
Curcumin is the active ingredient in turmeric, and when you look at all
the
research, it’s curcumin that delivers the anti-inflammatory and
anti-ageing
benefits that the super-spice is famed for. So, up your curcumin
quotient.
Ayurvedic Herbs May Help Slow Down Ageing NDTV, March
2019
Turmeric, or haldi, is one kitchen ingredient that is widely used in a
number
of dishes across the world. Curcumin, an essential compound found in
turmeric,
is shown to possess powerful anti-ageing effect. According to the book,
'Healing Foods' by DK Publishing House, "Curcumin reduces the build-up
of the
protein amyloid-b in the brain. Amyloid-b causes oxidative (free
radical)
damage and inflammation in the brain and is one of the main causes of
Alzheimer's disease. Antioxidants in turmeric help to fight this
free-radical
damage." Best supplements for arthritis: The Ayurveda plant supplement
proven
to support joints Express, March
2019
Curcumin’s effect on reducing inflammation means it can also help
protect
your joints from wear and tear. “This includes easing symptoms of
arthritis
like joint movement and stiffness, according to a
2016
study in Journal of Medicinal Food.†Best supplements for diabetes
type 2 to
avoid high blood sugar symptoms Express, March
2019
Turmeric could help to lower your risk of high blood sugar, according
to The
Diabetes Council. Its active ingredient, curcumin, could help patients
to
improve their insulin sensitivity, it said. Diabetes patients that take
turmeric supplements could significantly lower their blood sugar levels
and
insulin resistance, it added. “Curcumin is the yellowish/orangish
powder
which gives turmeric its beautiful colour in curry powder,†said The
Diabetes
Council. “It is widely used in many regions of the world for its
pain-relieving features, improving digestion and liver functions. “A
study
discovered that curcumin decreases blood [sugar] levels and improved
the
sensitivity of insulin by reducing serum free fatty acids and
increasing fatty
acid oxidation.“Supplements containing curcumin significantly
decreased
fasting blood levels and insulin resistance in type 2 patients. “Use
of
curcumin also led to a significant decrease in serum, triglyceride
fats, and an
increase in lipoprotein lipase.†Crusade against cancer: New
treatment and
nutrients you can rely on The Heath Site, March
2019
Turmeric: It is rich in curcumin, a compound that is responsible for
its yellow
pigment. Being a powerful antioxidant, curcumin can potentially prevent
chronic
inflammation, responsible for some cancers. Just like ursolic acid, it
also
inhibits cancer cell growth. Curcumin is helpful in cancers pertaining
to
breast, ovary, uterus, kidney, bladder, brain, blood, colon and rectum,
liver,
pancreas, lung, etc. Add curcumin to your meals by sprinkling turmeric
in your
favourite dishes. In vitro effect of curcumin on Schistosoma species
viability
Experimental Parasitology, March
2019
Curcumin (CUR), the major phenolic compound present in rhizome of
turmeric
(Curcuma longa L.), has been traditionally used against various
diseases
including parasitic infections. CUR was found to affect the
antigenicity of
surface membrane molecules of S. haematobium, but not S. mansoni. Of
importance, CUR significantly (P < 0.05 to < 0.0001)
affected S.
mansoni eggs hatchability and viability, a ground for its use in
chemotherapy
of schistosomiasis mansoni and japonicum because of its increased
bioavailability in the gastrointestinal tract. The data together
emphasize that
CUR is a promising potential schistosomicidal drug. 20 Health benefits
of
Turmeric InfoLoving.com February
2019
Turmeric (Curcuma longa) is the root of a plant that belongs to the
same family
as ginger. It is even less known in western cuisine, except as part of
the
spice mixture curry. The specific orange-yellow color is what gives
curry
powder its yellow color. There are 3 different yellow pigments
(curcuminoids)
in the turmeric root and these are also the substances that give
turmeric its
beneficial effects. These curcuminoids all work anti-oxidatively,
anti-inflammatory, and are toxic to tumor cells. The most bioactive and
tested
substance of the three is curcumin that also has antiviral and
antifungal
properties. About 3% (in weight) of the turmeric root is curcumin.
Health
benefits of Turmeric is unlimited according to its uses. Most studies
on the
curative effect of turmeric are done with the extracted curcumin and
high doses
of 500 mg to 4 grams per day. To get that kind of quantities you have
to use
supplements with curcumin. This is especially true for people who are
really
sick or suffer from a specific condition. Curcumin Antidiabetic and
Anticancer
Potential Anticancer Research, February
2019
Curcumin and cinnamaldehyde have been previously reported to have
antidiabetic
and anticancer potentials. Curcumin and cinnamaldehyde decreased the
activity
of PTP1B, and had inhibitory effects on the viability of MCF-7 cancer
cells.
Curcumin had a significantly higher inhibitory effect than
cinnamaldehyde.
Conclusion: Curcumin can be considered a potential agent for the
treatment of
type-2 diabetes or cancer. Does turmeric/curcumin supplementation
improve
nonalcoholic fatty liver disease? Phytotherapy Research, February
2019
We performed a metaâ€analysis to evaluate the efficacy of
turmeric/curcumin
supplementation on serum alanine aminotransferase (ALT) and aspartate
aminotransferase (AST) in patients with nonalcoholic fatty liver
disease
(NAFLD). We searched PubMed, Scopus, Cochrane Library, ISI Web of
Science, and
Google Scholar up to November 20,
2018
. Results from pooled analysis revealed that turmeric/curcumin
supplementation
reduced ALT (MD: −7.31 UL/L, 95% CI [−13.16, −1.47], p = 0.014)
and AST
(MD: −4.68 UL/L, 95% CI [−8.75 −0.60], p = 0.026). When RCTs
stratified
on the basis of their treatment duration, the significant reduction in
serum
concentrations of ALT and AST was observed only in studies lasting less
than 12
weeks. This review suggests that turmeric/curcumin might have a
favorable
effect on serum concentrations of ALT and AST in patients with NAFLD.
Amazing
Health Benefits of Curcumin/Turmeric Supplements JottedLines.com,
February
2019
Turmeric is biologically closely related to Ginger and is a very common
ingredient in South Asian cuisines. Also called the Golden Spice, this
lustrous
golden-yellow spice is also treated as a herb whose properties are
associated
with purity and auspiciousness. One of the important compounds in
Turmeric is
Curcumin, which is credited for giving the spice its distinct color.
Recent
research has also revealed a gamut of health benefits that Curcumin
offers. We
all know that aging and debility are caused in part due to oxidative
damage
incurred by our cells. Free radicals that are ingested via the food we
eat
react with proteins, fatty acids & can even damage our DNA.
Curcumin capsules
essentially negate the action of free radicals on top of augmenting the
body’s own antioxidant enzymes. This way, Curcumin/Turmeric deals a
double
blow to free radicals. Curcumin supplements are found to instigate the
production of neurons in adults. Conventional wisdom had it that our
brain does
not create any more neurons once we are past childhood. But recent
theories
pertaining to neuroplasticity and neuroadaptibility have shown how our
brains
have amazing abilities to regenerate and restructure in constructive
ways to
enhance the survival potential of brain-injured patients. But this
process does
not happen in a vacuum. Under a regimen of certain nootropics like
Curcumin/Turmeric, BDNF levels were observed to increase significantly.
BDNF is
in essence a growth hormone that acts in the central nervous system.
Since BDNF
is found to be subdued in people suffering from various psychiatric and
neurological disorders, an increase in BDNF is expected to improve
these
conditions. A randomized, double-blind, placebo-controlled trial to
evaluate
the role of curcumin in prostate cancer patients Prostate, February
2019
The anti-cancer activities of curcumin are well-documented from
preclinical
studies using prostate cancer models. Our objective was to evaluate the
anti-cancer activity of oral curcumin in patients with prostate cancer.
The
proportion of patients with PSA progression during the active curcumin
treatment period (6 months) was significantly lower in the curcumin
group than
the placebo group (10.3% vs 30.2%, P = 0.0259). PSA elevation was
suppressed with curcumin intake during the curcumin administration
period.
Curcumin at this dose was well tolerated and safe. Turmeric is an
excellent aid
for digestion because it already contains many of the minerals,
vitamins,
antioxidants, fiber, and anti-inflammatory compounds you need to "help
acid
production, muscle movement, and nutrient absorption to keep things
moving like
they should." The curcumin in turmeric: • helps the muscle walls of
the
intestines relax • balances gut flora in the colon • increases
production
of stomach mucous • eliminates cholesterol • prevents gas and
bloating
during digestion • relieves IBS symptoms. Taking curcumin can
actually boost
BDNF levels back up over time and even reverse the damage. Higher
serotonin and
dopamine may also be side effects of taking curcumin. A study actually
found
that people that took curcumin in addition to Prozac fared better than
those
just on Prozac or just taking curcumin for depression. Curcumin: Can it
slow
cancer growth? Mayo Clinic, February
2019
Curcumin, a substance found in the spice turmeric, has long been used
in Asian
medicine to treat a variety of maladies. Now some research suggests
that
curcumin may help prevent or treat cancer. Curcumin is thought to have
antioxidant properties, which means it may decrease swelling and
inflammation.
It's being explored as a cancer treatment in part because inflammation
appears
to play a role in cancer. Laboratory and animal research suggests that
curcumin
may prevent cancer, slow the spread of cancer, make chemotherapy more
effective
and protect healthy cells from damage by radiation therapy. Curcumin is
being
studied for use in many types of cancer. Curcumin a known anti
inflammatory and
antioxidant agent International Journal of Molecular Biology: Open
Access,
February
2019
Curcumin is an active yellow color curcuminoid compound which is a
naturally
occurring plant pigment that is mostly found in turmeric and is native
to
Southeast Asia and India.1 It has an earthy odor and somewhat bitter
taste and
is mostly used in culinary.2 It is reported that pure turmeric residues
contains about 3 percent of curcumin by weight.3 However curcumin is
also
available in the form of turmeric extract supplements which contains
higher
concentration of curcumin.4 It exhibits strong anti-inflammatory and
antioxidant properties.5 In addition to that it is an excellent healing
agent.6Health benefits of curcuminSome health benefits of curcumin are
as
follows:Relieves inflammationCurcumin is well known for its
anti-inflammatory
property that reduces chronic inflammation occurring in a number of
medical
conditions such as arthritis, bowel disease, heart disease, cancer, and
diabetes etc.7 It has the ability to effectively block the function of
those
enzymes that contributes in inflammatory pathway.8Supports skin
healthAntioxidant property of curcuminhelps in neutralizing free
radicals that
causes cell damage.9 In addition to that it accelerates healing of the
wounds
and collagen deposition in the skin.10 Curcumin is found to effective
in
treating psoriasis, dermatitis and scabies.11Lowers high blood
sugarDiabetes
associated symptoms such as impaired wound healing, increased thirst,
vision
loss, nerve damage, weight loss etc could be overcome by the use of
curcumin
which increases insulin secretion to reduce high glucose level in the
blood.12,13Treatment of cancersCurcumin has an anti-cancerous effect on
the
growth of cancerous and tumour cells.14 It inhibits the function of
cancer
inducing growth factors and enzymes and blocks the signaling pathway
hat is
involved in the development of cancer in organs like breast, colon,
pancreas
and lungs.15,16Treatment of mental illnessesCurcumin aids in the
treatment of
depression and anxiety by reducing its associated symptoms.17 It
increase the
levels of omega-3 fatty acid that promotes the development of
brain.18Prevents
blood clottingCurcumin reduces platelet aggregation in the blood by
inhibiting
the formation of thromboxanes that causes clot formation in conditions
like
pulmonary embolism, stroke and deep vein thrombosis.19Reduces joint
painRelieve
rheumatoid arthritis related symptoms like stiffness, pain, swelling
etc.20Regulates high cholesterol levelCurcumin boost cardiac health by
lowering
high cholesterol levels in blood.21Improves detoxificationCurcumin
stimulates
detoxification in order to protect the liver from diseases, allowing
removal of
toxins and cancer causing substances from the body.22Enhance brain
functionCurcumin maintains cognitive function and prevent the risks of
neurodegenerative diseases such as Parkinson’s and Alzheimer’s.23
It
elevates the amount of brain derived neuro tropic factors which is
involved in
enhancing brain function, improving memory and reduces oxidative
damage.24,2
Nootropic Supplements to Boost Memory & Brain Function SD
Entertainer, February
2019
Found in turmeric, curcumin has been shown to increase mental focus
while
reducing brain fog. The curcuminoids found in curcumin are effective at
fighting oxidative stress caused by free radicals, boosting neural
connections
in the process. Curcumin and Cancer Cancer Therapy Advisor, February
2019
Curcumin inhibits cell proliferation and induces cell cycle arrest,
apoptosis,
and senescence — through various mechanisms, across multiple
different types
of cancer cell lines. Curcumin has been shown to decrease the
expression of
multiple different enzymes, transcription factors, inflammatory
cytokines,
growth factors, and other cell-signaling components that are important
for
cancer growth and progression. Curcumin downregulates the expression of
the
transcription factor NF-κB, which is commonly highly expressed by
cancer cells
and is known to promote the development of cancer, metastasis, and
tumor
growth.2 In addition, curcumin arrests the cell cycle at the G1/S or
G2/M
phases by inhibition of different cyclins. Curcumin also induces
apoptosis
through caspase-dependent pathways, and decreases the expression of
antiapoptotic proteins. Curcumin has been evaluated in animal models of
different cancer types.3 These studies have generally shown that
curcumin has
antiproliferative effects. For example, a mouse model of colorectal
cancer
(CRC) that was treated by intraperitoneal injection of curcumin or
vehicle
control demonstrated that curcumin prolonged life and inhibited tumor
growth.4
These data also suggest that curcumin upregulated the miRNA miR-130a,
which
decreased the Wnt/β-catenin pathway and led to prolonged survival.
Studies in
animal models of breast cancer demonstrated that curcumin also
downregulates
NF-κB, reduces metastasis, and inhibits angiogenic signaling resulting
in
decreased microvessel formation.5 Animal studies of pancreatic cancer
have also
demonstrated that curcumin inhibits tumor growth, suppresses
proliferation, and
reduces angiogenesis. A powerful antioxidant: Curcumin protects your
heart from
damage caused by diabetes and smoking Plant Medicine, February
2019
To protect your heart from damage caused by diabetes and smoking, take
curcumin
supplements. A study published in the African Journal of Traditional,
Complementary and Alternative Medicines found that curcumin protects
the heart
from the combined oxidative stress induced by diabetes and nicotine. In
the
study, researchers from King Saud University in Saudi Arabia assessed
the
ability of curcumin to ameliorate the combined oxidative stress induced
by
diabetes and smoking which can cause diabetic cardiomyopathy. Diabetes
and
cigarette smoking, which both cause oxidative stress, are primary
factors that
cause cardiovascular diseases. Curcumin is known to have protective
effects
against hyperglycemia-induced oxidative stress. When curcumin was
administered,
it inhibited the diabetic and nicotine-induced oxidative stress, which
was seen
by the normalization of the plasma cardiac marker troponin I and CK-MB.
Based
on these findings, the researchers concluded that curcumin has a
protective
effect on heart tissues against the combined oxidative stress induced
by
diabetes and nicotine. Curcumin can also keep the heart healthy and
protect it
from diseases by improving the function of the endothelium or blood
vessel
lining. According to Healthline, this improvement in the blood vessel
lining
can significantly reduce the risk of endothelial dysfunction, which is a
primary risk factor of heart disease. It prevents the endothelium from
regulating blood pressure and blood clotting properly. Many other
studies have
confirmed this beneficial effect of curcumin. One study even suggested
that
curcumin is as effective as exercise in this respect. Another study
suggested
daily supplementation of curcumin can improve heart health by improving
cholesterol levels and reducing inflammation. This, in turn, may
prevent the
onset of atherosclerosis, which is a disease in which plaque builds up
inside
the arteries. Spice may protect against breast cancer MiceTimes,
February
2019
Studies have shown that curcumin (the main chemical component of
turmeric) has
a number of valuable properties. In particular, curcumin can play a
supportive
role in the prevention of Alzheimer’s disease – it starts the
process of
protein production, which is struggling with brain damage by free
radicals. In
addition, it was revealed that curcumin can help in the treatment of
skin
cancer. The study, conducted by researchers from the cancer Center to
them.
Andersen at Texas a & m University (USA), curcumin was administered
in the
affected melanoma cell line, stimulated the destruction of malignant
cells in
tumors. There is also reason to believe that curcumin prevents the
development
of breast cancer. Expressive about this show in particular, experiments
on mice
conducted in the same the University of Texas. Now scientists are
actively
exploring other potential therapeutic properties of curcumin, in
particular,
for the treatment of multiple myeloma and pancreatic cancer, and the
prevention
of oral cancer. Which herbs help reduce inflammation? Medical News
Today,
February
2019
Turmeric typically comes in the form of a yellow powder from the root
of the
turmeric plant. It contains a chemical called curcumin, which may have
anti-inflammatory properties. Several studies have shown that turmeric
can help
reduce inflammation and discomfort in people with arthritis. It works
by
limiting the production of molecules called cytokines, which cause
inflammation. Researchers continue to investigate how curcumin affects
inflammation in a range of other conditions, such as inflammatory bowel
disease. Curcumin has the most substantial evidence base for its
anti-inflammatory effects compared with other herbal remedies. Turmeric
helps
prevent diabetes Orissa Post, February
2019
Curcumin which is a component of turmeric helps prevent fatty deposits
in blood
vessels and development of fat tissues. So, adding turmeric in diet
helps one
maintain a healthy weight. Turmeric also promotes healthy bones by
decreasing
loss of bone minerals in the body. Curcumin shows heart health benefits
by
‘multiple mechanisms’ Nutra Ingredients, February
2019
In addition to the total and LDL cholesterol reductions, the
researchers noted
that HDL cholesterol was unaffected by curcumin addition to the diet.
“These
results support our hypothesis and indicate that curcumin may prevent
the
progression of atherosclerosis by reducing lipid accumulation. It
appears that
curcumin may prevent the progression of atherosclerosis by reducing
lipid
accumulation on the aortic endothelium. Can curcumin improve exercise
performance in those with heart failure? Medical News Bulletin,
February
2019
Curcumin administration restored muscle force and prevented rapid
fatigue.
Finally, the authors demonstrated that the positive effects of curcumin
on CHF
mice were attributed to improved Nrf2 signaling and not due to improved
cardiac
function. In conclusion, the data reaffirmed the authors’ hypothesis
that
impaired Nrf2 signaling in skeletal muscle of CHF mice contributes to
exercise
intolerance. More specifically, impaired Nrf2 signaling prevents the
skeletal
muscle from defending itself against CHF-associated oxidative stress,
which
likely affects skeletal muscle performance and reduces exercise
capacity. These
findings were further strengthened by the notion that curcumin, a Nrf2
signaling promoter, improved exercise capacity in mice with chronic
failure
without noticeable improvements in heart function and blood flow.
Collectively,
the authors found that targeting the Nrf2 signaling pathway may improve
exercise capacity and overall quality of life in patients with chronic
heart
failure. Can ginger, turmeric and lemon juice reduce blood sugar?
Legit.ng
February
2019
The component of the popular curry spice, turmeric, also can help to
lower the
high index to normal blood sugar level. Curcumin, polyphenol and
antioxidants
play a vital role in this process. They reduce the amount of glucose in
blood
by slowing down its formation the liver. Diabetes mellitus: Blood
sugar-lowering ginger + other root vegetables for type 2 diabetes The
Health
Site, February
2019
Turmeric root: Curcumin, found in turmeric exerts helps moderate
insulin levels
and enhance the efficacy of anti-diabetic drugs. Antioxidant-rich
turmeric
fights free radicals and reduces insulin resistance in the body. A
study
conducted by Department of Pediatrics, Louisiana State University
Health
Sciences Center revealed that curcumin present in turmeric prevents
protein
glycosylation (where the protein molecule is altered) and lipid
peroxidation
(oxidative degradation of lipids), thereby increasing the person’s
sensitivity to lower blood sugar levels. Three lesser known facts of
turmeric
Baltimore Post Examiner, February
2019
Turmeric is an anti-inflammatory- The active ingredient in turmeric is
something call curcumin, which is known for fighting inflammation and
being
full of antioxidants. The curcumin in turmeric fights inflammation at
the
molecular level, blocking a molecule called NF-kB, which is linked to
many
different inflammatory diseases like arthritis and IBD. 2. It helps
with
depression - Taking curcumin can actually boost BDNF levels back up
over time
and even reverse the damage. Higher serotonin and dopamine may also be
side
effects of taking curcumin. 3. Turmeric helps with digestion - Turmeric
is an
excellent aid for digestion because it already contains many of the
minerals,
vitamins, antioxidants, fiber, and anti-inflammatory compounds you need
to
"help acid production. The curcumin in turmeric has many benefits which
includes the muscle walls of the intestines relax, balances gut flora
in the
colon increases production of stomach mucous, eliminates cholesterol,
prevents
gas and bloating during digestion and relieves IBS symptoms. Foods that
can
boost your brain power Savannah Now, February
2019
This spice, commonly found in Indian food, turns out to have an almost
endless
list of health benefits. It has been tied to improving gastrointestinal
issues,
and reducing the chances of getting heart disease, cancer and
Alzheimer’s.
Turmeric has also been found to reduce inflammation, primarily due to a
compound in it called curcumin. Diseases like depression and
Alzheimer’s have
been linked to lower levels of brain-derived neurotrophic factor
(BDNF), a type
of growth hormone that helps with the formation of new neural
connections in
the brain. Turns out curcumin has been found to increase brain levels
of BDNF.
So by adding turmeric to soups and other dishes, you’ll be delaying
or even
reversing the effects of declining brain function. Inhibition mechanism
of
cathepsin B by curcumin molecule: a DFT study Theoretical Chemistry,
February
2019
One of the natural compounds named curcumin has a well-documented
history of
medicine in India, which is currently in clinical trials for the
treatment of
various cancers. However, the inhibition mechanism of the curcumin
molecule is
not yet clear. In this present study, the inhibition of cathepsin B by
the
curcumin has been studied by quantum chemical methods using DFT method
at
M062X/6-31 + g(d,p)//B3LYP/6-31g(d) level of theory to obtain a
complete
picture of possible reaction paths. Based on the obtained results, the
Cys29
can undergo nucleophilic attack at any one of the four reactive sites
of the
curcumin. The low activation energy 1.43 kcal/mol along with low
negative
reaction energy − 6.82 kcal/mol suggests that attack of Cys29 at
C63 atom
is the most feasible reaction path. These results suggest that curcumin
can be
used to develop less toxic cathepsin B inhibitors for the treatment of
cancer
disease. Science confirms turmeric as effective as 14 drugs Health Nut
News,
February
2019
If ever there were an herb that puts existential fear into the bottom
line of
pharmaceutical companies, its turmeric. Are mesonutrients the new
macronutrients? Femina, February
2019
Mesonutrients are the active compounds that are present in each food,
which are
responsible for good health. Typically found in foods that are
classified as
superfoods, it is not just important to eat these foods – it is
important to
eat them the right way, so as to obtain the maximum benefits of the
mesonutrients. One of the key mesonutrients is a staple in the Indian
kitchen
– turmeric. It has over 200 active compounds, and the key compound to
watch
out for is curcumin, which has anti-cancer and anti-inflammatory
benefits. The
Unsung Benefits of Turmeric... and Why You Should Use It Women.com,
February
2019
The active ingredient in turmeric is something call curcumin, which is
known
for fighting inflammation and being full of antioxidants. The curcumin
in
turmeric fights inflammation at the molecular level, blocking a
molecule called
NF-kB, which is linked to many different inflammatory diseases like
arthritis
and IBD. Studies have found turmeric to be just as effective as
medication but
without the side effects that many anti-inflammatory medications have.
In fact,
one study found of rheumatoid arthritis found 500 mg a day of curcumin
was more
beneficial than diclofenac, an anti-inflammatory drug. Impact of
curcumin on
energy metabolism in HIV infection: A case study. Phytother Res,
February
2019
Curcumin is a natural bioactive compound, which interacts with
molecular
targets and holds important metabolic properties. Oral curcumin
supplementation
can positively modulate the energy metabolism of people living with
HIV/AIDS
using the ART. Efficacy of curcumin for management of oral submucous
fibrosis:
a systematic review of randomized clinical trials Science Direct,
February
2019
Six clinical trials comprising 298 patients were included. All studies
found
curcumin to be effective in the management of OSF. Three studies found
significantly higher improvement in burning sensation in the curcumin
group
compared to controls, whereas three studies found comparable results.
With
regards to clinical signs, two studies showed better improvement in
mouth
opening in the curcumin group; three studies reported no differences in
effectiveness; and only one study found curcumin to be inferior to
conventional
therapy. The available evidence remains inconclusive but suggests that
curcumin
is a promising effective treatment option for the management of
patients with
OSF. Further well-designed clinical trials with large sample sizes and
adequate
follow-up periods are highly warranted. Curcumin improves the effect of
a
reduced insulin dose on glycemic control and oxidative stress in
streptozotocinâ€diabetic rats Phytotherapy Research, February
2019
Isolated treatments using curcumin or insulin in a reduced dose (1
U/day)
decreased glycemia, dyslipidemia, and biomarkers of liver and kidney
damage and
increased the activity of hepatic antioxidants (superoxide dismutase
and
glutathione peroxidase), however, only to a lesser extent than
4â€U/day
insulin, without improvements in catalase activity or plasma lipid
peroxidation. Decreases in glycemia, dyslipidemia, and tissue damage
markers
were more evident in the curcumin + 1â€U/day insulin treatment than
those seen
in isolated treatments. The activity of hepatic antioxidants, including
catalase, was further increased, and biomarkers of oxidative damage
were
decreased. Curcumin with a reduced insulin dose appears to be a
promising
strategy for combating the complications associated with diabetes and
oxidative
stress. Curcumin Suppresses Hepatic Stellate Cell-Induced
Hepatocarcinoma
Angiogenesis Oxidative Medicine and Cellular Longevity, February
2019
Curcumin could significantly suppress the HSC-induced effects in HCC
and could
abrogate ROS and HIF-1α expression in HCC. HIF-1α or connective
tissue growth
factor (CTGF) knockdown could abolish the aforementioned curcumin
affection.
Moreover, CTGF is a downstream gene of HIF-1α. In addition, nuclear
factor
E2-related factor 2 (Nrf2) and glutathione (GSH) are involved in
curcumin
protection of HCC. These data indicate that curcumin may induce ROS
scavenging
by upregulating Nrf2 and GSH, thus inhibiting HIF-1α stabilization to
suppress
CTGF expression to exhibit its protection on HCC. Curcumin has a
promising
therapeutic effect on HCC. CTGF is responsible for curcumin-induced
protection
in HCC. Curcumin ameliorates glyoxylate-induced calcium oxalate
deposition and
renal injuries in mice Sciene Direct, February
2019
Curcumin, the predominant active component of turmeric, has been shown
to have
pleiotropic biological and pharmacological properties, such as
antioxidant,
anti-inflammatory and antifibrotic effects. Curcumin could
significantly
alleviate CaOx crystal deposition in the mouse kidney and the
concurrent renal
tissue injury. The underlying mechanism involved the combination of
antioxidant, anti-apoptotic, inhibiting autophagy, anti-inflammatory,
and
antifibrotic activity and the ability to decrease expression of OPN and
CD44
through the Nrf2 signaling pathway. The pleiotropic antilithic
properties,
combined with the minimal side effects, make curcumin a good potential
choice
to prevent and treat new or recurrent nephrolithiasis. Curcumin
supplementation
reduces insulin resistance and blood lipids in individuals with high
risk of
type 2 diabetes Lipids in Health and Disease, February
2019
nsulin sensitivity was significantly improved in the CC supplemented
group
(32.7 ± 10.3%) compared to PL (P = 0.009). FO and CC-Curcumin
tended
to improve insulin sensitivity by 14.6 ± 8.5% and 8.8 ± 7.7%
respectively, but the difference did not reach significance.
Triglyceride
levels were further increased in the PL (26.9 ± 7.4%), however, CC
and
CC-Curcumin supplementation reduced the triglycerides, Curcumin
resulted in the
greatest reduction in triglycerides (− 16.4 ± 4.5%,
P < 0.001).
Conclusion Reduction in insulin resistance and triglycerides by
curcumin and
LCn-3PUFA appears to be attractive strategies for lowering the risk of
developing T2D Curcumin attenuates adhesion molecules and matrix
metalloproteinase expression in hypercholesterolemic rabbits Science
Direct,
February
2019
Curcumin, the yellow substance found in turmeric, possesses
antioxidant,
anti-inflammation, anticancer, and lipid-lowering properties. Curcumin
reduced
the levels of total cholesterol, triglyceride, low-density lipoprotein
cholesterol, and oxidized low-density lipoprotein cholesterol in serum
by
30.7%, 41.3%, 30.4%, and 66.9% (all P < .05), respectively, but did
not affect
high-density lipoprotein cholesterol levels. In addition, curcumin
attenuated
HCD-induced CD36 expression, circulating inflammatory cytokines, and
soluble
adhesive molecule levels. Curcumin reduced the mRNA and protein
expression of
intracellular adhesion molecule-1, vascular cell adhesion molecule-1,
P-selectin, and monocyte chemotactic protein-1, and it inhibited
HCD-induced
up-regulation of MMP-1, MMP-2, and MMP-9. Our results demonstrate that
curcumin
exerts an antiatherosclerotic effect, which is mediated by multiple
mechanisms
that include lowering serum lipids and oxidized low-density
lipoprotein, thus
modulating the proinflammatory cytokine levels and altering adhesion
molecules
and MMP gene expression. 4 Health Benefits Of Turmeric Medical Daily,
January
2019
"Turmeric has natural anti-inflammatory compounds called curcuminoids,
and
these curcuminoids have been associated with a positive effect on
various
diseases," said Anya Guy, a Mayo Clinic dietitian. Inflammation, as you
may
know, it the cause of several long-term health conditions. As a result,
many
studies have examined the potential of turmeric to ward off heart
disease or
reduce the risk of certain cancers. It is said that curcumin can help
in
reducing inflammation in pancreatic, fat and muscle cells. While most
research
on the link has involved rats, there was a clinical study in
2015
which saw 44 human participants experiencing a healthy weight loss over
the
course of two months. In a review published in
2016
, participants from many trials reported that their
osteoarthritis-related pain
had reduced after taking curcumin. "Its efficacy in reducing pain,
physical
function, and quality of life among osteoarthritic patients has been
demonstrated in many clinical trials," the authors wrote. Effects of
oral
curcumin ingested before or after eccentric exercise on markers of
muscle
damage and inflammation. Scand J Med Sci Sports, January
2019
We examined the effect of curcumin (CUR) ingestion before or after
exercise on
changes in muscle damage and inflammatory responses after exercise.
Increases
in IL-8 were significantly reduced 12 h after exercise when curcumin
was
ingested before exercise. In Exp. 2, compared to the PLA subjects, MVC
torque
and ROM were higher 3-7 days and 2-7 days after exercise (P<0.05),
respectively, whereas muscle soreness and CK activity were lower 3-6
days and
5-7 days after exercise (P<0.05), respectively, in curcumin
subjects. Curcumin
ingestion before exercise could attenuate acute inflammation, and after
exercise could attenuate muscle damage and facilitate faster recovery. 6
Things
That Happen To Your Body When You Eat Turmeric Every Day Healthy Food
House,
January
2019
Turmeric is a potent anti-inflammatory, due to the presence of numerous
anti-inflammatory compounds, such as curcumin, one of its most abundant
compounds. After reviewing more than 700 studies, Dr. James Duke, a
well-respected ethnobotanist, found that turmeric effectively
outperformed many
pharmaceutical drugs prescribed for various chronic, debilitative
conditions,
without causing any significant side effects. Curcumin eliminates
plaque
buildup in the arteries, and thus lowers the risk of atherosclerosis,
which can
cause a heart attack or stroke. It also lowers bad cholesterol known as
LDL and
prevents the formation of blood clots. Researchers have shown that
curcumin
triggers the production of bile in the gallbladder, and turmeric acts
as a
potential safeguard against remission in the case of ulcerative
colitis.
Turmeric has excellent anti-inflammatory properties, and rheumatoid
arthritis
patients who supplemented curcumin into their diets found that it led
to a
“reduction in tenderness†and a reduction in “disease
activityâ€.
Curcumin improves our ability to learn and process in different
environments
and prevents the development of neurodegenerative conditions, such as
–
dementia disorders and Alzheimer’s. Scientists have even proven that
turmeric
may aid in neuroplasticity, which is the development of new brain
connections.
According to Dr.Mercola: Curcumin is capable of crossing your
blood-brain
barrier, which is one factor that has led researchers to investigate
its
potential as a neuroprotective agent for neurological disorders such as
Parkinson’s and Alzheimer’s disease. The potent antioxidant and
anti-inflammatory properties of curcumin suggest it may also promote
brain
health in general. In the case of Alzheimer’s, recent animal
research14 has
discovered another bioactive ingredient in turmeric, besides curcumin,
that
adds to its neuroprotective effects. According to researchers at the
American
Cancer Society, curcumin“ interferes with several important molecular
pathways involved in cancer development, growth, and spread.â€
Moreover, the
US National Library of Medicine and National Institutes of Health
published a
study which showed that curcumin has potent cancer-fighting properties:
“The
activity of curcumin reported against leukemia and lymphoma,
gastrointestinal
cancers, genitourinary cancers, breast cancer, ovarian cancer, head and
neck
squamous cell carcinoma, lung cancer, melanoma, neurological cancers,
and
sarcoma reflects its ability to affect multiple targets. Thus, an
“old-ageâ€
disease such as cancer requires an “age-old†treatment.†“As
noted by
Dr. William LaValley—one of the leading natural medicine cancer
physicians
whom I’ve previously interviewed on this topic—curcumin is unique
in that
it appears to be universally useful for just about every type of
cancer. This
is odd, considering the fact that cancer consists of a wide variety of
different molecular pathologies. One reason for this universal
anti-cancer
proclivity is curcumin’s ability to affect multiple molecular
targets, via
multiple pathways. Once it gets into a cell, it affects more than 100
different
molecular pathways. And, as explained by Dr. LaValley, whether the
curcumin
molecule causes an increase in activity of a particular molecular
target, or
decrease/inhibition of activity, studies repeatedly show that the end
result is
a potent anti-cancer activity.†How to live longer Express, January
2019
Turmeric is packed with curcumin, which helps relieve long-term
inflammation.
Several studies have shown signs of inflammation are reduced in people
who have
taken capsules containing curcumin. Long-term inflammation can lead to
health
problems like inflammatory bowel disease, some cancers, dementia and
arthritis.
Turmeric may also help brain health, as curcumin may prevent
amyloid-beta
plaques forming in the brain - one of the hallmarks of Alzheimer’s
disease -
and may also help break them down. In addition, some lab-based studies
have
suggested curcumin may be able to kill cancer cells, particularly in
the
breast, bowel, stomach and skin, and prevent them from growing. 11
Health
Benefits of Turmeric and Curcumin HealthSky, January
2019
Research shows that curcumin binds to toxic metals and acts as an
anti-inflammatory agent. Curcumin is also a strong antioxidant that
captures
and neutralizes free radicals (that are pathogenic particles). This
brings all
kinds of health benefits. Research shows that the curcumin in turmeric
has a
powerful anti-inflammatory effect. In some cases, it works better than
an
anti-inflammatory drug. The antioxidant effect of curcumin is very
strong:
animal research even shows that the antioxidant curcumin has a
detoxifying
effect in mercury poisoning. There are strong indications that the
substance
curcumin in yellow root has an inhibitory effect on the development of
cancer
cells. For example, research in rats has shown that curcumin can
partially
neutralize damage to cells in the liver, kidneys and brain, and thus
prevent
cancer in these organs. Research in humans shows that a curcumin
supplement
fights the pain better than the drug diclofenac. This is very
beneficial,
because the pain-relieving medication can cause serious side effects,
while the
natural substance curcumin does not damage the body. Alzheimer’s is
caused by
the fact that certain proteins (such as tau protein) clump in the
brain,
causing brain cells to die off. Studies in rats show that curcumin can
prevent
tau protein from coagulating. This keeps the brain healthy. Curcumin
plays a
major role in preventing and curing stomach ulcers, and supports a
poorly
functioning liver. Animal research shows that curcumin can reduce the
risk of
liver damage. Rats that were also given curcumin in their diet were
less likely
to suffer from liver disease than rats who did not. Research in rats
shows that
curcumin stimulates spatial memory. The rats given curcumin were
significantly
better at solving spatial puzzles than the rats that did not. In a
study with
121 people undergoing cardiac surgery, participants were given 4 grams
of
curcumin or placebo, a few days before they were operated. The
participants who
received curcumin were 65% less likely to have a heart attack in the
hospital.
A recent article from
2017
looked at all the research done on turmeric and depression. This
meta-analysis
shows that the substance curcumin is indeed a safe and effective
natural means
to reduce depressive feelings. Curcumin can reduce the symptoms of
depression,
both on its own and in combination with other herbs. A very interesting
outcome
is that curcumin can strengthen the effect of antidepressants: the
drugs for
depression work better if curcumin is taken as a supplement. Turmeric
capsules
also contain much more of the active ingredient curcumin than the spice
turmeric itself. In curcuma is about 3% curcumin, while that in
turmeric
capsules is 95%. Curcumin attenuates collagen-induced inflammatory
response
through the "gut-brain axis" J Neuroinflammation, January
2019
Previous studies have demonstrated that oral administration of curcumin
exhibited an anti-arthritic effect despite its poor bioavailability.
The
present study aimed to explore whether the gut-brain axis is involved
in the
therapeutic effect of curcumin. Oral administration of curcumin
restored the
imbalance between the sympathetic and parasympathetic tones in CIA rats
and
increased ChAT activity and expression of ChAT and VAChT in the gut,
brain, and
synovium. Additionally, VGX eliminated the effects of curcumin on
arthritis and
ACh biosynthesis and transport. Electrophysiological data showed that
curcumin
markedly increased neuronal excitability of the vagus nerve.
Furthermore,
selective α7 nAChR antagonists abolished the effects of curcumin on
CIA. Our
results demonstrate that curcumin attenuates CIA through the "gut-brain
axis"
by modulating the function of the cholinergic system. These findings
provide a
novel approach for mechanistic studies of anti-arthritic compounds with
low
oral absorption and bioavailability. This Is How Much Turmeric You Need
to
Reduce Inflammation Readers Digest, January
2019
Curcumin—the main active component which gives turmeric its
anti-inflammatory
and antioxidant properties—only makes up 3 percent of dry turmeric,
according
to Ali Webster PhD, RD, Associate Director of Nutrition Communications,
International Food Information Council Foundation. “Turmeric extracts
or
isolated curcumin found in dietary supplements are much higher in
curcumin, so
they’re more likely to have an impact on inflammation than the dried
spice,†she says. So a dash of turmeric in the occasional recipe may
not have
lasting anti-inflammatory effects—unless a person consumes turmeric
or
curcumin supplements on a regular basis, too. Here are 10 proven ways
to fight
inflammation. Most research says that taking in at least one gram of
curcumin
per day is necessary for measurable anti-inflammatory effects, Webster
says
Turmeric benefits: Use this yellow-colored powder for easing arthritis
pain The
Heath Site, January
2019
Many studies have vouched that a key compound in turmeric known as
‘curcumin’ fight against inflammation and it is helpful in treating
joint
disorders like arthritis. It has the ability to improve joint health
and reduce
arthritis pain as well. Curcumin attenuates hyperglycemia-driven
EGF-induced
invasive and migratory abilities of pancreatic cancer Oncology Report,
January
2019
Effects of high glucose were counter-balanced by curcumin. EGF-induced
proliferative, invasive and migratory abilities of BxPC-3 cells were
abrogated
by curcumin, LY 294002 and PD 98059. In addition, EGF-modulated
activation of
EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were
inhibited by curcumin. Taken together, the present study indicates that
curcumin suppresses hyperglycemia-driven EGF-induced invasion and
migration of
pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway
and its
downstream signaling molecules including ERK and Akt. Curcumin is a
potential
anticancer agent for pancreatic cancer. A Computational Study of the
Driving
Forces and Dynamics of Curcumin Binding to Amyloid-β Protofibrils
Journal of
Physical Chemistry, January
2019
We have recently shown that curcumin exerts a neuroprotective effect
against
Aβ40 induced toxicity on cultured neuronal cells through two possible
concerted pathways – ameliorating Aβ oligomer-induced toxicity and
inducing
the formation of nontoxic Aβ oligomers, both of which involve curcumin
binding
to Aβ oligomers. Our results show that curcumin binds to specific
hydrophobic
sites on the protofibril surface and that binding is generally
associated with
the concomitant complexation of curcumin into dimers, trimers, or
tetramers.
Curcumin also binds to the protofibril growth axis ends, but without
complexation. Analysis of the energetics of the binding process
revealed that
curcumin complexation contributes in an additive fashion to curcumin -
Aβ
protofibril interactions. Favorable curcumin-protofibril binding is
driven by a
combination of hydrophobic interactions between curcumin and
protofibril,
curcumin self-aggregation, and solvation effects. Benefits of Turmeric
Curcumin
for Inflammatory Orbital Pseudotumor Care 2, January
2019
Curcumin, the yellow pigment in turmeric thought to be responsible in
part for
the spice’s anti-inflammatory effects. Eighteen patients were given
curcumin
alone, and every one improved, showing “efficacy…comparable to
corticosteroid therapy,†but without any side effects. A larger,
follow-up
study was similarly encouraging. A total of 106 patients who had had a
uveitis
relapse in the year before starting curcumin were followed for a year.
As you
can see at 1:10 in my video in my video, only 19 had relapses in the
year after
starting curcumin. Altogether, the 106 patients had had multiple
relapses—a
total of 275 times—in the year before starting curcumin, but, in the
year on
curcumin, they had only 36 relapses. If turmeric curcumin works for
mild eye
inflammation and serious eye inflammation, what about really serious
eye
inflammation, like idiopathic inflammatory orbital pseudotumours.
Let’s break
that down: “Idiopathic†means doctors have no idea what causes
it—from
the Greek idios, as in idiot. “Orbital†refers to the bony cavity
that
houses our eyeball, and “pseudotumor,†as in not really a tumor. A
lot has
changed since the study was published in 2000. “[I]nflammatory
orbital
pseudotumour is now generally attributed to low-grade non-Hodgkin’s
lymphoma,†so it does appear to be a form of cancer. Well, what can
curcumin
do about it? The researchers decided to look at curcumin because the
available
treatments are so toxic—steroids, radiation, and chemotherapy. In
fact, all
of the patients in the study were initially put on steroids but had to
stop
them because they either did not work or they had to be withdrawn
because of
complications. The researchers didn’t want to use radiation because
they
didn’t want to blind anyone. But they had to do something. All of the
patients had so much swelling that they couldn’t move their eye as
they
normally would. If only there were some cheap, simple, and safe
solution. Four
out of the five patients who completed the study with curcumin therapy
had a
full response, defined as complete recovery with no residual signs or
symptoms.
In fact, complete regression of the eye dislocation and swelling
occurred in
all five out of five patients, but one patient continued to suffer some
residual effects. Curcumin ameliorates monosodium urate-induced gouty
arthritis
through Nod-like receptor 3 inflammasome mediation via inhibiting
nuclear
factor-kappa B signaling. Journal of Cellular Biochemisty, January
2019
Curcumin is an active ingredient possessing anti-inflammatory efficacy.
Curcumin regulated the production of cytokines by suppressing the
expression of
inflammasome key components, including NLRP3, caspase-1. Further
studies showed
that the suppressive efficacy of curcumin on inflammasome was mediated
by
inhibiting MSU-induced NF-κB signaling activation. Intraperitoneal
administration of curcumin could ameliorate symptoms of MSU-induced
gouty
arthritis, including the joint circumference, infiltration of
neutrophils in
knee joints, and production of IL-1β, TNF-α, and elastase. Western
blot
analysis revealed that the levels of NLRP3, procaspase-1, caspase-1,
pro-IL-1β, and IL-1β were downregulated by curcumin in vivo. These
results
indicated that curcumin could effectively ameliorate MSU
crystal-induced gouty
arthritis through NLRP3 inflammasome mediation via inhibiting NF-κB
signaling
both in vitro and in vivo, suggesting a promising active ingredient for
the
prevention and treatment of gouty arthritis. Impact of dietary
supplements,
diet on metabolic health explored in review Nutritional Outlook,
January
2019
Previous research indicates that curcumin (Curcuma longa), resveratrol,
and
quercetin, one of major flavonoids found in many plants, may exert a
beneficial
effect on the above metabolic parameters. Curcumin, specifically, has a
polyphenolic structure with antioxidant and anti-inflammatory
properties,
according to a number of the studies analyzed. Inflammation and
oxidative
stress are key contributors to metabolic syndrome and NAFLD. Curry
spice boosts
exercise performance Science Daily, December
2018
New research suggests that curcumin, a main ingredient in curry, may
improve
exercise intolerance related to heart failure. The study is published
ahead of
print in the Journal of Applied Physiology. Curcumin, a chemical that
comes
from the turmeric plant, has been used as a traditional Asian medicine
for
centuries, primarily to treat gastrointestinal ailments and skin
wounds.
Studies increasingly suggest that the compound may prevent or limit
muscle
wasting associated with a number of health conditions, including heart
failure.
Researchers from the University of Nebraska Medical Center theorized
that a
reduction in the normal signaling of Nrf2, a protein that regulates the
expression of antioxidant enzymes, may play a role in the impaired
expression
of antioxidant enzymes. They examined the effects of curcumin, which is
known
to promote activation of Nrf2, on a mouse model of heart failure with
reduced
ejection fraction. One group of mice with heart failure received daily
doses of
curcumin for 12 weeks, and another group did not receive treatment. The
heart
failure groups were compared to a control group of healthy mice that
received
curcumin and an untreated control group. The research team measured the
exercise capacity of all the mice before and after curcumin treatment.
The
researchers also examined muscle fiber samples to assess enzyme
expression
levels. They found that expression of Nrf2 increased and levels of
antioxidant
enzymes improved in the animals with heart failure that were given
curcumin. In
addition, both groups that received curcumin -- even the animals
without heart
failure -- had improved exercise capacity when compared with the
untreated
groups, suggesting the effects of curcumin on skeletal muscle is not
exclusive
to heart failure. "These data suggest that activation of Nrf2 in
skeletal
muscle may represent a novel therapeutic strategy to improve ...
quality of
life" in people with heart failure with reduced ejection fraction, the
researchers wrote. Curcumin Showing Promise In Alzheimer’s Research
World
Health, December
2018
Curcumin/Turmeric has been used for thousands of years as both food and
medicine. Growing bodies of research are showing it can help to fight
Alzheimer’s disease, not only as a preventive but possibly as a cure.
The
potential of turmeric to help combat this debilitating disease cannot
be
ignored by mainstream medicine any longer, effects of this and others
like it
must be investigated more thoroughly; and experts are describing the
effects of
turmeric on Alzheimer’s patients as being remarkable. Much like most
plant
medicines turmeric has been largely ignored thanks to big pharma and
the
pharmaceutical industry’s all consuming grip on modern medicine and
the
blindly obedient public who follow by shunning those who dare think
outside the
sheepeople approved box. Scientists are beginning to wake up to the
fact that
medicinal plants do exist, and some even outperform big pharma’s
concoctions.
Recent research has shown that daily turmeric supplements taken for 12
weeks
produced sizeable benefits in Alzheimer’s patients. Within one year
patients
began to recognize family members again according the the researchers.
In all
the study yielded impressive and promising results. Curcumin/turmeric
has been
studied for ability to help obliterate cancer, ward off
neurodegenerative
diseases and more, it is believed that curcumin extracts its benefits
by
enhancing processes associated with chemical signalling in cells and
genes
while boosting resistance to inflammation and stress. Curcumin/turmeric
is also
thought to help protect brain cells against premature aging, by binding
to
toxic proteins to help prevent forming of dangerous plaques while
reducing
oxidative stress and damage, lowering cholesterol, reducing
inflammation
signaling molecules, promoting clean up, and inducing protective
mechanisms
within the brain. University of Southern California researchers have
also
identified curcumin as prime source of improvement in Alzheimer’s
patients
via its antioxidant, anti-inflammatory and lipophilic action. Due to
the
various effects of curcumin including delayed degradation of neurons,
metal-chelation, anti-inflammatory, antioxidant and decreased microglia
formation, and decreased beta amyloid plaques overall memory in
Alzheimer’s
patients has improved. The team has concluded that curcumin is a
promising
treatment for Alzheimer’s disease. The natural polyphenol curcumin
induces
apoptosis in esophageal squamous cell cancer Journal of Experimental
& Clinical
Cancer Research, December
2018
Curcumin is able to exert anti-tumor action through inhibiting the
STAT3
signaling pathway. Giving its wide use in traditional medicines with
low
toxicity and few adverse reactions, it is conceivable that curcumin
might be
further explored as a unique STAT3 inhibitor for anti-cancer therapies.
New
research on curcumin’s health benefits Natural Products Insider,
December
2018
Sports nutrition is an up-and-coming benefit sector for curcumin,
especially in
light of its potential to reduce inflammation and soreness caused by
strenuous
exercise. The antioxidant benefits of curcumin and its ability to
modulate
inflammatory pathways underscores its potential as an adjunct to
recovery.1 In
a recent randomized, double-blind, placebo-controlled study, curcumin
was shown
to be an effective supplement for recovery after strenuous exercise.2
An
additional study also reported a reduction in 24-hour pain scores as
well as
increased muscle performance after a muscle-damaging exercise.3
Curcumin is
also finding potential in heart health, where the effects of its
anti-inflammatory properties are being researched. Recently, a highly
bioavailable form of curcumin was studied in a healthy population to
examine
its role in endothelial function, which plays a critical role in
cardiovascular
health.4 Curcumin’s direct impact on healthy circulation was measured
using
flow mediated dilation (FMD). The randomized, double-blind,
placebo-controlled
study showed supplementing with 200 mg of curcumin had a clinically
meaningful
impact on potentially reducing cardiovascular disease by up to 50
percent in
healthy individuals. Curcumin and Vitamin D Treatment May Stabilize
Disease in
Patients with CLL and SLL Cure Today, December
2018
In patients with chronic lymphocytic leukemia (CLL) or small
lymphocytic
lymphoma (SLL), high doses of curcumin and vitamin D could help
stabilize the
disease, according to new research presented at the American Society of
Hematology’s (ASH) Annual Meeting in San Diego. Previous clinical
studies
have shown that curcumin, a chemical derived from turmeric, and vitamin
D are
both safe in high doses for patients with solid tumors. Additionally,
the
research presented at ASH notes that curcumin has been found to disrupt
CLL
cell interactions, induce cell death independent of DNA damage and
upregulate
vitamin D receptor levels in malignant cells. Given this, the
researchers set
out to examine whether the combination of curcumin and vitamin D could
safely
delay disease progression in patients with CLL/SLL. In their phase 2,
open-label trial, the team enrolled a total of 35 previously untreated
patients
with asymptomatic, stage 0 to 2 CLL/SLL. The majority of patients (51
percent)
were males with CLL (97 percent); 51 percent were stage 0, and 49
percent were
stage 1. The median age was 60 years old. The 30 evaluable patients
started out
by receiving 8 grams of curcumin daily for one week, then added 10,000
IU of
vitamin D3 orally. Both treatments were taken for up to six 4-week
cycles.
Patients received a median of five cycles, and the treatment was well
tolerated. The most frequent side effects were
diarrhea/gastrointestinal upset
in 69 percent of patients, 14 percent of which experienced this at a
grade 3.
Eighteen patients completed all six cycles, while 10 withdrew consent,
four
discontinued treatment due to adverse effects and three patients’
disease
progressed while on treatment. The primary endpoint of the study was
the
overall response rate (ORR), while secondary endpoints included
event-free
survival (EFS), time to next treatment overall survival (OS) and time
to next
treatment. Researchers also evaluated the levels of curcumin and
vitamin D
activity within CLL cells by using flow cytometry. The best response
was stable
disease in 28 of the 30 evaluable patients (93 percent). After a median
follow
up of 29 months, EFS was 72 percent, 74.1 percent had not started new
CLL
treatment, and OS was 100 percent. While no responses were seen, the
majority
of evaluable patients maintained stable disease while in treatment. The
researchers concluded that because the combination of curcumin and
high-dose
vitamin D is safe and well-tolerated, additional extended follow up is
now
planned to examine how this treatment impacts the long-term progression
of
disease in patients with CLL/SLL. Curcumin prevented human autocrine
growth
hormone in breast cancer cells Molecular Biology Reports, December
2018
Curcumin (diferuloylmethane), a polyphenol derived from turmeric
(Curcuma
longa), has anti-proliferative, anti-carcinogenic, anti-hormonal effect
via
acting on PI3K/Akt, NF-κB and JAK/STAT signaling. This study aimed to
investigate the role of NF-κB signaling and miR-182-96-183 cluster
expression
profile on autocrine GH-mediated curcumin resistance, which was
prevented by
time-dependent curcumin treatment in T47D breast cancer cells. Dose-
and
time-dependent effect of curcumin on T47D wt and GH+ breast cancer
cells were
evaluated by MTT cell viability and trypan blue assay. Apoptotic effect
of
curcumin was determined by PI and Annexin V/PI FACS flow analysis.
Immunoblotting performed to investigate the effect of curcumin on
PI3K/Akt/MAPK, NF-κB signaling. miR182-96-183 cluster expression
profile was
observed by qRT-PCR. Overexpression of GH triggered resistant profile
against
curcumin (20 µM) treatment for 24 h, but this resistance was
accomplished
following 48 h curcumin exposure. Concomitantly, forced GH induced
invasion and
metastasis through EMT and NF-κB activation were prevented by
long-term
curcumin exposure in T47D cells. Moreover, 48 h curcumin treatment
prevented
the autocrine GH-mediated miR-182-96-183 cluster expression stimulation
in T47D
cells. In consequence, curcumin treatment for 48 h, prevented autocrine
GH-triggered invasion-metastasis, EMT activation through inhibiting
NF-κB
signaling and miR-182-96-183 cluster expression and induced apoptotic
cell
death by modulating Bcl-2 family members in T47D breast cancer cells.
Curcumin
targets aggressive and lethal forms of cancer while leaving
noncancerous cells
unharmed Natural News, November
2018
Curcumin, the most active constituent in turmeric, is a powerful
antioxidant
and is responsible for most of the spice’s magical health benefits.
Studies
have already shown, for example, that curcumin can cut the growth rate
of
prostate cancer tumor progression in half. Other studies have found
that
supplementing with curcumin can lead to a 36 percent decline in lung
tumor size
and a 40 percent reduction in colon tumor development. In a new study
published
in the Proceedings of the National Academy of Sciences, researchers
used models
to show how turmeric can inhibit the DYRK2 enzyme. With the help of
x-ray
crystallography, they obtained 3-D images that show curcumin binding to
this
enzyme atomically. You might be wondering why we should be excited
about this.
It turns out that inhibiting the DYRK2 enzyme stops protein complexes
known as
proteasomes that are involved in cancer development. This action
interferes
with the proliferation of cancer cells, reducing tumors and slowing the
cancer’s growth. This is great news for sufferers of
proteasome-addicted
cancers, such as triple-negative breast cancer and multiple myeloma.
These
cancers depend on the proteasomes that curcumin inhibits for their
survival.
While pharmaceutical proteasome inhibitors do exist, they have the
undesirable
effect of also damaging noncancerous cells at the same time. Curcumin,
on the
other hand, does this without damaging any healthy cells. Moreover, it
carries
very few side effects and can get the job done in smaller dosages.
Perhaps even
more excitingly, this isn’t the only way that curcumin helps fight
cancer. It
can also stop the blood vessels that give tumors life from growing and
developing, and it can turn off the genes that promote the development
of
tumors. At the same time, it can help your body’s immune system to
find and
destroy any malignant cells. In addition, it can stop the production of
the
adhesion molecules that enable cancer cells to stick to cell walls. It
also
protects cell DNA from incurring cancerous mutations from environmental
toxins
and radiation. In other words, curcumin takes a multi-pronged approach
to
fighting cancer, seemingly trying to stop it at every turn. Curcumin
Inhibits
Age Related Vascular Changes WorldHealth.net November
2018
This study investigated effects of long term use of curcumin on
vascular aging
and chronic inflammation which is the cause of arteriosclerotic
disease. 8 week
old C57BL/6J mice were fed high fat diets or curcumin mixed high fat
diets
until the animals reached 80 weeks of age. Expression of antioxidant
enzymes,
heme oxygenase-1, oxidative stress, vascular aging, and inflammatory
changes in
the aorta were examined. Oxidative stress increased with decreases in
sirt1
expression in the aorta, followed by increased amounts of senescent
cells and
enhanced inflammation in the animals fed the high fat diets alone. In
the
animals fed curcumin mixed high fat diets heme oxygenase-1 was induced
in the
aorta with suppression of oxidative stress; sirt1 expression was shown
in the
aorta to remain at a level comparable to that of 8 week old mice with
suppression of increased senescent cells and enhanced inflammation
resolving
issues associated with high fat diets. According to the researchers
curcumin
may be a food with prophylactic functions against arteriosclerotic
diseases,
helping to control weight gain, increases in blood glucose levels and
blood
cholesterol levels associated with long term consumption of high fat
diets; as
well as multifaceted benefits such as anti-cancer effects,
anti-inflammatory
action, and antioxidative action, along with various physiological
activities
in vivo. Curcumin Targets Cancer Cells WorldHealth.net November
2018
Curcumin is a powerful antioxidant that is attributed to most of the
health
benefits. It has been shown to cut growth rates of prostate cancer
tumor
progression by 50%; supplementation can lead to 36% decline in lung
cancer
tumor size, and 40% reduction in colon tumor development. In this study
researchers used models to show how turmeric can inhibit DYRK2 enzymes
using
x-ray crystallography to obtain 3D images to demonstrate curcumin
binding to
this enzyme atomically. Inhibiting these enzymes stops proteasome
protein
complexes involved in cancer development, which interferes with cancer
cell
proliferation reducing and slowing cancer growth. Proteasome addicted
cancer
cells such as triple negative breast cancer and multiple myeloma depend
on
proteasomes for survival that curcumin inhibits. Pharmaceutical
inhibitors do
exist, but they also damage healthy cells along with the cancerous
cells at the
same time. Curcumin can do this while leaving healthy cells
undisturbed, which
is great news. Not only can curcumin target and help to fight cancer,
it helps
to stop blood vessels that give tumors life from growing and
developing, and
turns off genes that promote development of tumors. Curcumin also
protects DNA
from incurring cancerous mutations from radiation and environmental
toxins. It
would seem curcumin takes multipronged approaches to fighting cancer by
trying
to stop it at every turn. Curcumin very effective senolytic affects
Scienceblog.com November
2018
Recent data suggest that curcumin, a phytochemical with cancer
chemopreventive
potential, might be useful in the treatment of several solid and
hematological
malignancies. Overall, this work shows that curcumin is capable of
inducing
topo−DNA complexes in cells with both topo I and topo II and
increases the
evidence suggesting that this dietary agent has potential to be tested
in
cancer chemotherapy. This spice helps against tumors BobrTimes.com
November
2018
Curcumin has the property to engage in connection with a specific
enzyme DYRK2
– this combined substance slows down the activity of cancer cells,
preventing
their rapid growth and uncontrolled reproduction in the body.
Laboratory tests
have shown that when curcumin is combined with medicinal substances for
the
treatment of specific varieties of tumors of blood, it greatly enhances
their
effectiveness and even reduces the side effects. Curcumin Inhibits
Age-Related
Vascular Changes in Aged Mice Fed a High-Fat Diet Nutrients, November
2018
Inhibiting the onset of arteriosclerotic disease, which has been
increasing due
to the westernized diet and aging, is a significant social challenge.
Curcumin,
a type of polyphenol, has anti-oxidative effects and anti-inflammatory
action
and is expected to treat and to have prophylactic effects on different
diseases. In this study, we examined the effects of long-term
administration of
curcumin on vascular aging and chronic inflammation—the causes of
arteriosclerotic disease. These results suggest that curcumin might be a
food
with a prophylactic function against arteriosclerotic disease. Ancient
drug
curcumin impedes 26S proteasome activity by direct inhibition of
dual-specificity tyrosine-regulated kinase 2 PNAS, November
2018
Curcumin, the active ingredient in Curcuma longa, has been in medicinal
use
since ancient times. Interestingly, curcumin synergizes with the
therapeutic
proteasome inhibitor carfilzomib to induce apoptosis in a variety of
proteasome-addicted cancer cells, while this drug combination exhibits
modest
to no cytotoxicity to noncancerous cells. In a breast cancer xenograft
model,
curcumin treatment significantly reduces tumor burden in
immunocompromised
mice, showing a similar antitumor effect as CRISPR/Cas9-mediated DYRK2
depletion. These results reveal an unexpected role of curcumin in
DYRK2-proteasome inhibition and provide a proof-of-concept that
pharmacological
manipulation of proteasome regulators may offer new opportunities for
anticancer treatment. Benefits of Golden Turmeric Healthline.com
October
2018
Research shows that ginger, cinnamon and curcumin — the active
ingredient in
turmeric — have potent anti-inflammatory properties (6, 7, 8).
Studies even
suggest that the anti-inflammatory effects of curcumin are comparable
to those
of some pharmaceutical drugs with none of the side effects (9, 10).
These
anti-inflammatory effects may reduce joint pain from osteoarthritis and
rheumatoid arthritis.For instance, one study in 45 people with
rheumatoid
arthritis found that 500 grams of curcumin daily reduced joint pain
more than
50 grams of a common arthritis drug or a combination of curcumin and
the drug
(11). Similarly, in a 6-week study in 247 people with osteoarthritis,
those
given ginger extract experienced less pain and required less pain
medication
than those given a placebo (12). Studies show that curcumin may
increase levels
of brain-derived neurotrophic factor (BDNF). BDNF is a compound that
helps your
brain form new connections and promotes the growth of brain cells (13).
Low
levels of BDNF may be linked to brain disorders, including
Alzheimer’s
disease (14, 15). In a 6-week study, 60 individuals with major
depressive
disorders took either curcumin, an antidepressant or a combination.
Those given
only curcumin experienced similar improvements as those given
antidepressants,
while the combination group noticed the most benefits (23). Depression
may also
be linked to low levels of brain-derived neurotrophic factor (BDNF). As
curcumin appears to boost levels of BDNF, it may have the potential to
reduce
symptoms of depression (24). curcumin may improve the function of your
blood
vessel linings — known as endothelial function. Proper endothelial
function
is important for a healthy heart (28). In one study, people undergoing
heart
surgery were given either 4 grams of curcumin or a placebo a few days
before
and after their surgery. Those given curcumin were 65% less likely to
experience a heart attack during their hospital stay than people in the
placebo
group (29). Curcumin, the active ingredient in turmeric, may also kill
cancerous cells and prevent the growth of new blood vessels in tumors,
limiting
their ability to spread (44, 45). Health Benefits of Turmeric and
Curcumin
Mommyish.com October
2018
Turmeric and curcumin are believed to be as effective, if not more
effective,
than the most powerful anti-inflammatory drugs. Curcumin can increase
brain-derived neurotrophic factor (BDNF), a growth hormone that
functions in
your brain. Low levels of BDNF have been linked to brain diseases like
Alzheimer’s and depression. Turmeric and curcumin may be effective at
delaying some of those brain diseases, or even reversing them. Curcumin
is a
powerful antioxidant that can protect your body from free radicals, and
boost
your body’s own antioxidant enzymes. In addition to improving
inflammation
and oxidation, turmeric and curcumin improves the function of the
endothelium,
which is the lining of your blood vessels. Endothelial dysfunction is a
major
driving force behind heart disease, as it affects your body’s blood
clotting
and ability and blood pressure. In one of the most highly-regarded
studies on
curcumin, the group who received a curcumin supplement lowered their
risk of
heart attack by 65%. Several studies have shown that curcumin was more
effective at managing the painful symptoms of arthritis than the
strongest
anti-inflammatory drugs. In an interesting controlled study,
participants were
put into three groups. One group took Prozac, one group took a curcumin
supplement, and one group took both in conjunction. After six weeks,
the group
that took curcumin showed as much improvement as the group that took
Prozac.
The group that fared the best in the study was the one that took both.
10
Things That Happen When You Eat More Turmeric Readers Digest, October
2018
We all know turmeric is an anti-inflammatory powerhouse, but do you
know which
parts of the body it can benefit the most? Is it Time for a
Curcumin-Based
Mesothelioma Treatment? Surviving Mesotheliom, October
2018
Yet another scientific study appears to confirm the power of the
spice-derived
compound curcumin as a weapon against malignant pleural mesothelioma.
The
Chinese researchers who conducted the latest study say the substance
has the
potential to be the basis of a whole new way of treating this
aggressive
asbestos cancer. This team tested curcumin on a line of mouse
mesothelioma
cells, both in the lab and in live animals, and published their
promising
results in the prestigious International Journal of Oncology. As a
plant
polyphenol, curcumin has powerful anti-inflammatory and antioxidant
properties
and has been the subject of numerous mesothelioma studies around the
world in
just the last three years. Curcumin appears to work in several ways,
including
disrupting mesothelioma cell DNA, inducing programmed cell death, and
preventing the formation of a tumor-supporting blood supply
(angiogenesis).
Just as importantly — and in sharp contrast to other types of
mesothelioma
treatments — curcumin has very low toxicity. In the current study,
Chinese
researchers used a variety of sophisticated testing tools to assess the
impact
of curcumin on a mouse mesothelioma cell line. They applied the
compound to
cells in the lab and in mesothelioma tumors implanted under the skin of
live
mice. They found that curcumin exerted a range damaging effects on the
mesothelioma cells including: Disruption of vital signaling pathways
Induction
of apoptosis Inhibition of blood vessel formation Prevention of
proliferation
signals The results prompted lead author Chengke Zhang of the
Department of
Thoracic Surgery at The Second Hospital of Shandong University to
conclude,
“Curcumin may be potent enough to be developed as a novel therapeutic
agent
for the treatment of malignant pleural mesothelioma.†A number of
previous
studies have also suggested that curcumin has merit as an alternative
therapy
for mesothelioma. A study conducted last year at the University of Rome
found
that mice infected with peritoneal mesothelioma lived longer when they
were
given curcumin. A few months later, French researchers used curcumin to
shrink
sarcomatoid tumors in lab rats. In
2015
, researchers in Australia conducted the first experiments of curcumin
on human
mesothelioma cells and concluded that the compound could be a helpful
supplement to standard treatment for certain mesothelioma patients. In
another
2015
study, Italian researchers found that curcumin was even more effective
against
mesothelioma when delivered into cells via nanoparticles which overcame
cells’ natural resistance to the compound. Curcumin is of particular
interest
to mesothelioma researchers because there are so few viable treatment
options
for this deadly cancer. Curcumin Helping To Prevent Fluoride Induced
Damage In
The Brain Worldhealth.net, October
2018
Adding supplementation of curcumin significantly reduced toxic effects
of
fluoride to close to normal levels by augmenting antioxidant defense
via its
scavenging properties, and provided evidence of having therapeutic
roles
against oxidative stress mediated neurodegeneration. This is not the
only study
to demonstrate the remarkable brain saving properties curcumin
possesses; there
are over 200 peer reviewed published studies indicating curcumin is a
neuroprotective agent. When one takes into consideration the many
chemical
insults faced on a daily basis in the post industrial world,
turmeric/curcumin
may very well be one of the world’s most important herbs, which has
over 800
evidence based health applications. Curcumin, Commonly Found In Indian
Food,
Improves Memory, Mood, Attention Studyfinds.com September
2018
Those who took the curcumin performed better on the cognitive tests,
showing
better memory recall and attention spans compared to those who took the
placebo. In fact, individuals in the curcumin group showed an average
of 28
percent improvement on the memory test at 18 months. Thirty
participants also
agreed to undergo brain scans to test for levels of amyloid and tau —
which
are key markers for Alzheimer’s disease — at the beginning of the
study and
at the follow-up period. After 18 months, those who took curcumin
showed much
lower levels of the two proteins than those in the placebo group. This
Spice
Can Protect Your Liver Belmarra Health, September
2018
The latest research findings uncovered that curcumin may have the
potential to
protect the liver from non-alcoholic fatty liver disease (NAFLD) and
may even
be a form of treatment. In rat studies, researchers uncovered that
curcumin
reduced hepatocellular inflammation along with providing other
benefits. Role
of Curcumin and Gallic acid as antioxidants PLOS One, September
2018
Curcumin and/or Gallic acid alleviated the adverse effects caused by
tramadol.
In addition, patients should be advice to take Curcumin and/or Gallic
acid
prior to tramadol treatment to alleviate the hepatic and renal
toxicities
caused by tramadol. Enhanced anticancer effects of low-dose curcumin
with
non-invasive pulsed electric field on PANC-1 cells Dovepress, September
2018
A non-contact approach using low intensity electric field in a pulsed
waveform
could enhance the anticancer effect of low-dose curcumin on PANC-1
cells
through triggering both extrinsic and intrinsic pathways. The findings
highlight the potential of this alternative treatment, non-invasive
electric
field and curcumin, to increase therapeutic efficacy with minimum
cytotoxicity
and side effects, which may provide a new aspect of cancer treatment in
combination of PEF and other anticancer agents. Chemoprevention of
inflammation-related colorectal cancer by curcumin- and
maltodextrin-enriched
dietetic formulation in animal model Carcinogenesis, September
2018
Seventy were treated with azoxymethane (AOM)/dextran sulfate sodium and
divided
into two groups: 35 received standard diet and 35 enriched formulation
(curcumin, boswellic acids, silymarin and maltodextrins). Our results
are
promising for a successful anti-inflammatory and chemopreventive effect
of
enriched formulation in CRC arising from inflamed tissue. Benefits of
the
Golden Spice Herb: Turmeric SD Entertainer, August
2018
Turmeric, used in traditional Chinese medicine, can also be an aid in
the
stagnation of blood or even epilepsy, due to its ability to lower blood
pressure. These properties are aided by healing compounds curcuminoids,
or
Curcumin which is the active substance in turmeric. In the article
Curcumin: A
Review of It’s Effects on Human Health, Susan Hewlings and Douglas
Kalman
write, “Curcumin has been shown to improve systemic markers of
oxidative
stress. There is evidence that it can increase serum activities of
antioxidants
such as superoxide dismutase.†The possibilities are endless and this
little
spice that can help your body heal as well as be a special tool that
can
transform your overall health, allowing you to explore the options of
natural
remedies when it comes to your well-being. This popular spice may
prevent
diabetes Bobr Times, August
2018
Curcumin as antioxidant component of the plant has properties to
normalize
insulin production, thus preventing type II diabetes. According to them
the
action of curcumin is associated with the reduction of fat content in
tissues
– mice this effect was observed even though high-calorie foods.
Preliminary
research has also demonstrated anti-cancer properties of curcumin.
Experts from
Saint Louis University in Missouri it was found that part of the
substance
turmeric curcumin and silymarin do not allow cancer cells to divide and
thus
can help in the treatment and prevention of colon cancer. Priyanka
Chopra is
Obsessed With Turmeric Because, Well, Who Isn’t? Organic Authority,
August
2018
Rich in bioflavonoids, beta-carotene, and vitamins C and A, as well as a
host
of other nutrients, its main claim to fame is the active compound
curcumin,
which may be responsible for many of the spices noted health benefits,
including anticarcinogenic properties. A new study seemed to reaffirm
the
turmeric’s reputation as an anti-cancer fighter, in addition to being
beneficial in the prevention of chronic disease and inflammatory
conditions
like rheumatoid arthritis, IBD and asthma. Protect Against 'Evolving
Stroke'
NewsMax, August
2018
One type of stroke event is “evolving stroke.†In these cases, the
neurological damage — weakness, speech impairment — gradually gets
worse
after the first few days. When this happens, the penumbra neurons,
instead of
returning to normal, start dying off and expanding the damage. This can
occur
for a number of reasons, but most often it is because of a burst of
free
radicals when the blood supply is re-established. We call this
reperfusion
injury. This happens because of the high oxygen content of the
returning blood
flooding the penumbra region, which generates high levels of new free
radicals.
Numerous studies have shown that such things as magnesium, curcumin,
quercetin,
baicalein, hesperidin, resveratrol, naringenin, DHA, vitamin E, vitamin
C, and
anthocyanadins can prevent this damage and protect the brain during a
stroke.
Not only do these compounds suppress free radicals and lipid
peroxidation, they
are also powerful inhibitors of microglial activation and
immunoexcitotoxicity.
Adaptogens That Will Improve Your Brain Function Care2, August
2018
If you haven’t heard, turmeric contains a compound known as curcumin,
which
acts as a powerful anti-inflammatory in the body. What’s more,
curcumin also
has neuron stimulating, healing, and protective properties, which is
why it is
being researched as a potential healer for those who have suffered from
Alzheimer’s or a stroke. Other research has shown that curcumin may
possess
powerful antidepressant properties, potentially making it a natural,
side
effect-free option for those suffering from mild and moderate
depression.
Pretty much, if you have an inflammatory condition, curcumin is on the
case.
Curcumin supplementation regulates lipid metabolism in broiler chickens
Academic, August
2018
Curcumin plays an important role in reduction abdominal fat deposition
by
decreasing the hepatic and plasma lipid profile and affecting the
expression
levels of genes related to lipogenesis and lipolysis including ACC,
FAS,
SREBP-1c, ACLY, PPARα, and CPT-I. X-ray Crystallography Reveals How
Curcumin
Inhibits Cancer WorldHealth.net August
2018
X-ray crystallography and kinase-inhibitor specificity profiling has
revealed
that curcumin binds to the kinase enzyme dual specificity tyrosine
regulated
kinase at the atomic level, an interaction that impairs cell
proliferation and
reduces cancer burden, as published in the Proceedings of the National
Academy
of Sciences. Researchers from the University of California in
collaboration
with Peking University and Zhejiang University discovered the
previously
unreported co-crystal structure of curcumin to bind to protein kinase
target
biochemical interaction of the naturally occurring turmeric compound
binding to
and inhibiting DYRK2 leading to impediment of proteasome; who also note
that
curcurmin alone may not be the answer as it is expelled from the body
quickly,
to be an effective drug it needs to be modified to enter the
bloodstream and
stay long enough to target cancer. Kinases IKK and GSK3 enzymes were
thought to
be curcumin targets leading to anticancer effects, but the co-crystal
structure
of curcumin with DYRK2 along with an 140 panel kinase inhibitor
profiling has
revealed curcumin binds strongly to active sites of DYRK2 inhibiting it
500
times more potently than GSK3 or IKK, showing anticancer potential for
chemo-sensitive and proteasome inhibitor resistant and adapted cancers.
Curcumin: More Powerful Than Drugs NewsMax, August
2018
Curcumin, an organic compound extracted from the spice turmeric, is a
flavonoid. It is the curcumin that gives the spice its bright yellow
color.
Turmeric, a relative of ginger, is in the family of plants called
Zingiberaceae. The spice turmeric contains a number of beneficial
compounds,
but the most important are the curcuminoids: curcumin,
demethyoxycurcumin, and
bisdemethoxycurcumin. • Antimalarial • Antibacterial • Antiviral
•
Antioxidant • Antiseptic •Anticancer It is also neuroprotective,
lowers
cholesterol, and reduces hardening of the arteries. Studies have shown
that
this increases curcumin absorption by 11 times in plasma (the liquid
component
of blood in which cells are suspended) and fourfold in the brain.
Mixing with
oil also allows concentrations of curcumin to become high enough in the
brain
to provide protection against inflammation. Human studies have shown
that even
in very high doses (as much as 10,000 mg per day), curcumin has little
toxicity. It is very safe and can even be given intravenously. Curry
powder
slows cancer growth New Telegraph, August
2018
Scientists from the University of California said a chemical in curry
powder
could fight cancer. The scientists have suggested that curcumin, the
chemical
in turmeric, could slow the growth of tumours in breast and blood
cancers.
Curcumin is a bright yellow chemical produced by some plants. It is the
principal curcuminoid of turmeric, a member of the ginger family,
Zingiberaceae. It is sold as an herbal supplement, cosmetics
ingredient, food
flavouring, and food colouring. It does this by making cancer cells
less able
to break down or destroy other cells. Curcumin could be used to fight
cancer
because when in the blood stream, it binds to a specific type of enzyme
called
DYRK2 and, when the two are connected, cells cannot reproduce as
quickly.
Co-author, Jack Dixon, said curcumin may offer new opportunities for
hard-to-treat triple-negative breast cancer and multiple myeloma
treatment.
Evidence-based complementary treatment of pancreatic cancer: a review
of
adjunct therapies including curcumin Cancer Management and Research,
August
2018
Curcumin is the most studied of the nutraceuticals that are considered
anticancer agents found in natural plants. Curcumin, from the plant
Curcuma
longa and a component of turmeric, has exhibited multiple anticancer
effects in
numerous studies in pancreatic cell lines and mice studies.95–114
When used
in combination, curcumin has also been shown to potentiate the effects
of other
cytotoxic agents, including gemcitabine, cisplatin, oxaliplatin, and
5-fluorouracil, in preclinical models of a variety of cancers.96,105
Most
importantly, it seems to prevent chemoresistance especially to
gemcitabine.102,104–109 A low incidence of cancer has been documented
in
countries that incorporate high consumption of turmeric root, of which
curcumin
is believed to be the active ingredient.110,111 After testing >1,000
different
potential agents for cancer prevention, the National Cancer Institute
has
chosen only 40, of which curcumin was included, to be moved to clinical
trials.112 In several mice studies, curcumin has been shown to prevent
cancer
including mammary adenocarcinoma, esophageal cancer, and familial
adenomatous
polyposis.113–115Curcumin has demonstrated a plethora of functions
affecting
various cell signaling pathways at multiple levels, as shown in Figure
3.
Studies have identified numerous factors inhibited by curcumin related
to
cancer cell survival, proliferation, invasion, angiogenesis, and
metastasis,
suppression of apoptosis, and chemoresistance. Curcumin has been shown
to
inhibit a variety of factors including STAT3,100 COX-2,117 survivin,100
miR-200, and miR-21,111 the hedgehog pathway,118 and IAP proteins.119
Additionally, it has been demonstrated to activate the cell cycle
inhibitors,
p27 and p27,94 and upregulate the p53 modulator of apoptosis.112
Curcumin has
been shown to inhibit pancreatic tumor growth and angiogenesis in mouse
models.120 Curcumin’s most important effect seems to stem from
inhibition of
the transcription factor NF-κB and all its downstream
products.96,97,110,117,118 Many lines of evidence suggest that NF-κB
plays a
major role in growth, proliferation, angiogenesis, and most
importantly,
chemoresistance.104–106,117,121 Becoming resistant to chemotherapy is
the
main cause of death in most pancreatic patients. Curcumin seems to
block this
resistance.122 For example, one study showed that resistance to
gemcitabine is
induced by NF-κB activity and that curcumin inhibits this process.107 A
recent
study demonstrated curcumin restores sensitivity in
gemcitabine-resistant
cancer cells and confirmed this finding in a xenograft mouse model.108
Curcumin
suppresses the progression of laryngeal squamous cell carcinoma
OncoTargets and
Therapy, July
2018
Curcumin is a polyphenol extracted from the rhizomes of Curcuma longa
with
extensive biological and pharmacological effects. Curcumin
administration
upregulated miR-145 expression in LSCC cells in a dose-dependent
manner.
miR-145 overexpression and curcumin treatment both markedly suppressed
cell
proliferation, migration and invasion and induced cell cycle arrest and
apoptosis in LSCC cells. Moreover, curcumin treatment reversed the
enhanced
effects on cell viability, migration and invasion and the inhibitory
effects on
apoptosis conferred by anti-miR-145 in LSCC cells. Curcumin treatment
dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR
pathway
and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR
pathway in
LSCC cells. Conclusion: Curcumin suppressed LSCC progression through
the
upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.
Conditions
Curcumin Helps Fight Care2, July
2018
Obesity: If you’re having trouble losing weight you might want to
consider
adding more turmeric to your diet and supplementing with curcumin.
That’s
because research in the journal Biofactors found that the spice
alleviated the
inflammation isolated as a cause in overweight and obesity. It not only
helped
with obesity, it helped to protect against some of the health-damaging
effects
of obesity. Ideally choose a standardized extract of curcumin. Memory
Boosting:
Research published in the Journal of Psychopharmacology showed that
within only
one hour after taking a supplement containing one of turmeric’s
active
ingredients, curcumin, study participants had a significant improvement
in
memory and attention tasks compared to the placebo group. Alzheimer’s
Protection: Research shows that the curcumin may even help to protect
the brain
against the plaque-formation found in Alzheimer’s disease. It seems
to work
by preventing the formation of beta amyloid plaques—which are key
factors in
Alzheimer’s disease. Even Alzheimer’s patients who exhibited severe
symptoms, including: dementia, irritability, agitation, anxiety and
apathy, had
excellent therapeutic results when taking curcumin, according to
another study
published in the Japanese medical journal known as Ayu. Colon Cancer
Prevention
and Treatment: Curcumin not only shows benefits for prostate cancer, it
has
been found in multiple studies to reduce colon cancer risk. In one
study
published in Cancer Prevention Research researchers found that curcumin
suppressed the ability of colon cancer cells to proliferate, suggesting
it may
be beneficial in preventing and treating the disease. Tendonitis: A
root
similar to gingerroot, turmeric contains a potent compound that, not
only gives
it its signature yellow color, but also its anti-inflammatory
properties. In a
study published in the Journal of Biological Chemistry researchers
found that
curcumin improved the healing of tendonitis, which involves
inflammation of the
tendons that help maintain our structural integrity. Urinary Tract
Infections:
Recent research in the Journal of International Molecular Sciences
found that
curcumin helps to prevent kidney stones from forming in the urinary
tract. It
appears to prevent them from crystallizing in the first place. Curcumin
increases glutathione production Inside Tucson, July
2018
The UA College of Nursing recently received a 1.6 million dollar grant
to
research the potential of curcumin at combatting the acute lung injury.
This
five-year grant from the National Institutes of Health allows
researchers to
study whether the non-pharmacological supplement curcumin can be used
as
medicine against the disease. Alcohol abuse depletes cells’
glutathione, an
important antioxidant in the lung. Research shows when glutathione
combines
with oxygen, it can result in fatal respiratory failure. Curcumin,
naturally
found in turmeric, has proven effective as a non-pharmacological
treatment for
a variety of inflammatory diseases, and increases glutathione
production.
Anti-Cancer Mechanism of Curcumin Outlined MedicalResearch.com July
2018
Curcumin is good for cancer prevention since it blocks inflammation and
tumor
cell metabolism. These two activities are likely to prevent cancer or
at least
to delay its development. Consider that delaying cancer development
means years
of healthy life while cancer therapy means life with cancer, which is
not the
same. We are working with pure curcumin, no derivates, no additives
with
commercial interest. University of Arizona Awarded Grant To Research
Healing
Powers Of Curcumin KJZZ, July
2018
The University of Arizona College of Nursing was awarded a $1.6 million
grant
to research the healing potential of the substance curcumin for acute
lung
injury. Acute respiratory distress syndrome can be lethal and is
expensive to
treat. Researcher Dr. Charles Downs said he hopes the study will lead
to the
development of a cure. “It looks like it may hold some promise in
this area
primarily because of its antioxidants and beneficial effects,†said
Downs.
Curcumin is a compound found in the spice turmeric and has been used to
reduce
inflammation. What exactly is curcumin and what is it good for? Mind
Body
Green, July
2018
Turmeric is a rhizome (underground root stem) of the leafy Curcuma
longa plant.
Also known as Indian saffron, turmeric has been a must-have ingredient
in
Indian cooking and medicine for thousands of years. Curcumin, the
powerful
medicinal compound that gives turmeric its health benefits, is best
consumed in
food, with fat and pepper. Curcumin can shrink tumors San Diego
Tribune, July
2018
In one clinical study on pancreatic cancer, two patients out of 25 had
good
responses to large, daily doses of curcumin. Those two experienced
tumor
shrinkage for three years. “That doesn’t sound like a lot but most
drugs
won’t work very well for pancreatic cancer.†Curcumin turns off
something
called NF-kappa B that increases the production of several types of
proteins
that promote tumor growth. Second, it promotes apoptosis, which is the
programmed death of cells in our bodies. Apopstosis is halted in cancer
cells,
allowing them to flourish. Curcumin reinvigorates that programmed cell
death.
Can curcumin really help with arthritis, inflammation and headaches?
WKTR, July
2018
"Turmeric contains the chemical curcumin, found safe in six human
trials,"
explained Dr. Light. "Curcumin, when studied, demonstrated
anti-inflammatory
activity inhibiting different parts of the inflammatory system.
Turmeric can be
used as an anti-inflammatory and may lessen the symptoms of arthritis
and
headache caused by inflammation." UA receives $1.6m grant to examine
the
healing potential of curcumin for acute lung injury Eureka Alert, July
2018
Curcumin, a compound found in turmeric, has proven effective as a
nonpharmacological treatment for a variety of inflammatory diseases,
and an
increase of GSH synthesis. Looking to evaluate curcumin's effectiveness
in
facilitating the normal production of GSH, University of Arizona
College of
Nursing Assistant Professor Charles Downs, PhD, ACNP-BC, FAAN, has
received a
five-year $1.6M RO1 grant from the National Institutes of Health. Using
a
carefully designed murine model in his study, "Using Proteomics to
Develop
Personalized Health Strategies to Prevent Lung Injury in Model
Systems," Dr.
Downs hopes to demonstrate that curcumin reverses impaired protein
function to
restore lung fluid balance. Acute respiratory distress syndrome occurs
in
response to inflammatory stresses such as pneumonia and is
characterized by
profound inflammation and a build-up of excess fluid in the lungs that
culminates in respiratory failure. Although researchers are aware of
the
physiological disorders associated with the syndrome, current therapies
are
supportive rather than curative, Dr. Downs said. Value Your Memory?
These
Nutrients Will Keep It Strong ZME Science, June
2018
Curcumin, the compound that makes turmeric bright yellow, has been in
the news
a lot lately because of its health benefits, and many of those benefits
center
on the brain. In particular, curcumin can reduce brain inflammation and
increase the availability of the antioxidant glutathione. Brain
inflammation is
a leading cause of neurological damage and degeneration, so find a way
to work
it into your diet, whether in curry, golden milk, or as a stand-alone
supplement. If you are going to take curcumin as a supplement, consider
mixing
it with coconut oil, olive oil, or even that brain health booster fish
oil for
improved absorption. Muscle Atrophy Cures Found At The Supermarket The
Eagle,
June
2018
Our lab has shown a causal role that reactive oxygen species (ROS) play
in
starting and maintaining this atrophy process. ROS are generated
through
metabolic and chemical reactions in the body and are normally referred
to as
free radicals in the general population. Disuse results in a spike of
ROS and
this causes movement of an enzyme nNOS (neuronal nitric oxide synthase)
from
the cell membrane to the interior of the cell. This movement of a
molecule that
normally resides at the cell membrane sets off a cascade of
intracellular
events that lead to the breakdown of the muscle cell. Our interventions
of fish
oil and curcumin aim at scavenging these excess ROS. By dealing with
the high
levels of ROS we can mitigate the cellular processes that lead to
muscle
breakdown and preserve muscle mass. It’s also important to note that
these
two interventions have been shown to diminish muscle atrophy when used
alone
and our lab wanted to see if combining both treatments would result in a
more
profound “rescue effect.†This intervention experiment is also
important
because many drugs created to combat muscle atrophy are quite expensive
and
often times have negative side effects. Fish oil and curcumin are not
toxic and
are easily available to any average person shopping at the local
Wal-Mart.
Curcumin Health Benefits SimpleMost.com June
2018
One of the star ingredients here is turmeric, and specifically the
curcumin
present in the golden spice. A
2013
study showed that curcumin has therapeutic properties for human
diseases such
as cancer and Alzheimer’s. Curcumin also offers a number of other
health
benefits, including increased antioxidant capacity of the body and the
ability
to neutralize free radicals. It’s also said to improve brain
function, lower
the risk of heart disease and help those suffering from arthritis by
reducing
inflammation. Plants That Help Your Brain and Memory Care2, June
2018
Curcumin, the active ingredient in turmeric, has been linked to a wide
variety
of health benefits. One study found that participants had significantly
improved memory and attention within one hour after taking a curcumin
supplement. Four weeks on the supplement enhanced their working memory,
energy
levels and calmness as well as lowered their stress levels. Turmeric
– What
is That? Kiowa County Press, June
2018
Curcumin is what gives turmeric its yellow-orange coloring. Curcumin is
the
active ingredient found in turmeric. It has been said that it may be a
contributor to helping break down fat cells in your body; and, because
of its
natural anti-inflammatory agents, turmeric may help reduce joint and
muscle
pain. Other positive effects of curcumin include aiding in digestion,
lower
cholesterol, relief of arthritis and cystic fibrosis symptoms,
prevention of
some cancers, and lower blood pressure. Reduce your risk of getting
cancer NZ
Herald, May
2018
Healthista's nutrition director, Rick Hay, has shared what foods are
best for a
cancer awareness diet and 10 tips to help boost your health. "Top of my
herb
and spice list is turmeric," says Hay. "The active ingredient is
curcumin which
is a key anti-inflammatory agent." Curcumin can stop cancer cells and
tumours
from growing, especially in regards to breast, bowel and skin cancer
cells.
Black pepper is also beneficial in helping the body to absorb curcumin.
Anti-inflammatory Turmeric Protects Against Diabetes ReliaWire.com May
2018
Curcumin is the main active ingredient in turmeric, which has proven
anti-inflammatory and anti-oxidant properties. This naturally sourced
and
bioactive compound is easy to produce, has no side effects and can help
to
reduce inflammation in an array of inflammatory diseases; including
obesity and
diabetes. Scientists from Shandong University in Jinan, China found
that
curcumin improved glucose tolerance and insulin sensitivity in mice
that were
fed a high fat diet; and that blocking activation of the NLRP3
inflammasome was
key to preventing high fat diet-induced insulin resistance. Top 3 Signs
of
Ageing: Why This Spice Could Be You Best Anti-Ageing Companion NDTV May
2018
Curcumin In Turmeric May Boost Memory and Uplift Mood too, claimed a
recent
study. The study, published in the American Journal of Geriatric
Psychiatry,
examined 40 adults between the ages of 50 and 90 years who had mild
memory
complaints.For the study, they were randomly assigned to receive either
a
placebo or 90 milligrammes of curcumin twice daily for 18 months.
People taking
curcumin improved by 28 per cent over the 18 months in their memory
tests.
There were mild improvements in mood for people taking curcumin.
According to
the researchers, taking this relatively safe form of curcumin could
provide
meaningful cognitive benefits over the years. One of the bets way to
include
Haldi in your diet is through Haldi doodh. According to Ayurveda expert
Ashutosh Gautam, "It is because curcumin has the ability to get
absorbed in the
fat and tissues of our body and that is how it benefits the body. Milk
becomes
a smooth medium through which curcumin travels better and speedier to
those
fats and tissues facilitating its better absorption". Why Turmeric Is
the
Golden Spice That'll Make Your Health Nice PopSugar, May
2018
The active compound in turmeric, curcumin, is great at decreasing
exercise-related muscle soreness due to its antioxidant properties. It
also
helps boost muscle recovery so you can get back to the gym right away.
If your
gut is easily irritated by certain foods, adding turmeric to your dish
or
having it as a shot before will help a lot with any bloat. Curcumin
works by
inhibiting enzymes that increase inflammation in the body. Healthy
Living:
Turmeric, more than a spice News Tribune, May
2018
Several studies on the effects of turmeric's active compound curcumin
found
reduced inflammation in people with osteoarthritis of the knee. Both
pain and
C-reactive protein levels were lowered. Testing showed collagen
breakdown and
overall disease activity was reduced. Additionally, research on
rheumatoid
arthritis found some patients found the anti-inflammatory properties as
beneficial as cortisone. How? Turmeric inhibits the breakdown of
arachidonic
acid. Turmeric's combination of antioxidant and anti-inflammatory
effects
explains why many people with joint disease find relief when they use
the spice
regularly. Turmeric can offer help with several digestive issues. The
University of Maryland Medical Center reported the curcumin in turmeric
stimulates the gallbladder to produce more bile. This may help improve
gas,
bloating, nausea, appetite loss, belching and stomach discomfort. The
curcumin
may also be beneficial in inflammatory bowel diseases, including
Crohn's
disease and ulcerative colitis. However, turmeric should not be used
with
stomach ulcers, as it may increase stomach acid in some people.
Turmeric also
has been shown to lower blood sugar and LDL cholesterol. It also keeps
platelets from clumping together, meaning it might stop blood clots
from
forming on your artery walls. Because of this people currently using
blood-thinning drugs should be aware the effect might be intensified
with
turmeric. Interactions of curcumin within the body improve insulin
resistance,
hyperglycemia, hyperlipidemia and other inflammatory symptoms
associated with
obesity and metabolic disorders. In addition, studies show curcumin
seems to
delay liver damage that can eventually lead to cirrhosis. Clinical
studies have
shown frequent use of turmeric to lower rates of breast, prostate, lung
and
colon cancer. Herbs that can give your weight loss plan a boost Times
of India,
May
2018
According to a
2009
study by Tufts University, turmeric can help your body burn fat. In the
study,
there were two groups of mice, one was fed curcumin while the other
wasn’t.
The results were that the group of mice that had curcumin lost more
weight than
the other group that did not have it. Turmeric is a warming spice, it
increases
the body heat which can boost your metabolism and provide other health
benefits. Healthy haldi Times of India, May
2018
Curcumin’s anti-inflammatory properties make it an effective immunity
booster, mitigating incidences of infection, disease. Curcumin helps
block the
conditions that lead to cardiovascular damage, which helps manage blood
pressure and reduces the formation of clots. More and more studies are
making
linkages between haldi and its positive effect on anxiety. Curcumin
seems to
boost serotonin – the happy hormone, while lowering cortisol – the
stress
hormone. It is the curcumin in turmeric that gives it its antioxidant
properties. Oxidative damage (the chemical reactions that oxygen
performs
inside our bodies) leads to the development and proliferation of free
radicals,
which are highly reactive molecules. Free radicals have the potential
to damage
organs and also create a crazy, disease-prone, inflamed environment
inside our
body. Antioxidants help flush out free radicals and also work as a
brilliant
anti-inflammatory. 5 Foods for Joint Pain Relief NewsMax, May
2018
The active ingredient in turmeric is curcumin, which has been shown to
suppress
the action of a number of chemical signals in the body, such as tumor
necrosis
factor, that attack joints. Curcumin also blocks other inflammatory
signals,
including those in the pro-inflammatory COX-2 pathway. A study
presented in the
journal, Experimental Neurology
(2016
), revealed that curcumin counteracted the outcome of traumatic brain
injury by
decreasing oxidative stress, and increasing synaptic simplicity and
cognition.
Turmeric also stimulates a key antioxidant pathway called Nrf2. A
healthy heart
diet MVariety.com May
2018
“A study of about 121 patients undergoing coronary artery bypass
disease
showed a positive response to turmeric. There was a 65 percent
decreased heart
attack rate for patients who were given a dose every day.†Forsyth
said
curcumin, a substance in turmeric, has a positive effect on your
endothelium,
which is the lining of your blood vessels. Endothelium is responsible
for
regulating blood clots, blood pressure, and all other factors that lead
to many
heart diseases. Researchers at the University of Toronto found that
curcumin
blocks a wide range of biochemical reactions involved in cardiac
hypertrophy
(enlargement of the heart chambers), inflammation, and fibrosis. Feed
your
brain well Times of India, May
2018
Curcumin: It is the active ingredient in turmeric. Curcumin has been
shown to
boost BDNF (Brain-Derived Neurotrophic Factor), which helps lower the
risk of
brain diseases. Curcumin works best when heated with food. It is known
to add
to brain clarity and reduce mind fogginess. To stay healthy, include
natural
spices in your diet Daily Nation, May
2018
der. Curcumin is a chemical compound found in turmeric, this compound
is
responsible for the anti-inflammatory, anti-cancer and antioxidant
properties
of turmeric. In isolation, absorption of curcumin in blood stream is
low,
however, the absorption can be enhanced by piperine found in black
pepper. As
an anti-inflammatory agent, curcumin attacks the inflammatory pathway,
on this
pathway, it blocks the NF-kB molecule from accessing the cell nuclei.
It is in
the nuclei where the NF-Kb molecule triggers the gene associated
inflammation,
which causes chronic diseases. Curcumin has a chemical structure that
has the
ability to inhibit the three major enzymes (lipoxygenase,
cyclooxygenase-2 and
inducible nitric oxide synthase) that promote inflammatory process.
Other
disorders whose risks can be reduced by curcumin include heart and
brain
diseases, osteoarthritis, depression, eye swelling, skin cancer and
age-related
ailments. Here's how Turmeric can help you lose weight E Times, May
2018
The primary antioxidant present in turmeric is curcumin. Turmeric is
said to
help one deal with stomach issues, metabolic disorders, obesity and
many more
problems. Though having huge quantities of turmeric is surely not a way
to lose
weight, but turmeric is said to reduce the inflammation associated with
obesity. Thus, it can give your weight loss plan a boost. Obesity leads
to
inflammation, which increases your risk of developing chronic diseases,
including diabetes and heart disease. Curcumin, which is an
antioxidant,
suppresses the inflammatory messaging in fat, pancreatic and muscle
cells. This
can help reduce high blood pressure, high cholesterol, high blood sugar
and
other metabolic conditions, says a study published in European Journal
of
Nutrition. Turmeric use linked to weight loss Citizen Digital, May
2018
Curcumin, an active ingredient in Turmeric, has a strong anti-oxidant
property.
This article highlights the various benefits of using the spice:
prevents heart
diseases improves immunity aids in weight loss and metabolism prevents
neurological diseases promotes brain health prevents cancer offers
excellent
anti-oxidant properties delays aging can be used as a natural
painkiller treats
skin pigmentation prevents hair loss helps treat dandruff cures stretch
marks
soothes burns heals cracked feet aids in exfoliation aids in diabetes
treatment
works as a natural antiseptic detoxifies the liver reduces menstrual
pain
treats digestive disorders. Want to fight your everyday blues? These
kitchen
ingredients may be the perfect solution for you TimesNowNews, April
2018
Turmeric is a widely used spice in Indian households. Apart from its
anti-inflammatory nature, the spice also brings a distinct flavour and
aroma to
your meal which has mood-lifting properties. There is a compound called
curcumin that has been linked to improving mood, according to a study
conducted
by UCLA. “Exactly how curcumin exerts its effects is not certain, but
it may
be due to its ability to reduce brain inflammation, which has been
linked to
both Alzheimer’s disease and major depression,†said Dr Gary Small,
director of geriatric psychiatry at UCLA’s Longevity Center and of
the
geriatric psychiatry division. Curcumin and a good book News Miner,
April
2018
Cumin and curcumin, which is found in turmeric, are both important
ingredients
in cuisines from North Africa to India, and both possess powerful
medicinal
qualities. Research at UCLA has shown curcumin has “improved memory
and mood
in people with mild, age-related memory loss.†Already known for its
anti-inflammatory and antioxidant properties, eating lots of
curcumin-rich
turmeric “has been suggested as a possible reason that senior
citizens in
India, where curcumin is a dietary staple, have a lower prevalence of
Alzheimer’s disease and better cognitive performance.†Is turmeric
really a
'wonder drug' for migraines? Daily Mail, April
2018
Good brands for curcumin will give you the milligram dosage of curcumin
specifically listed on the bottle which is why she recommends people
buy
curcumin supplements as opposed to turmeric. Although more research is
needed
to prove curcumin's effectiveness, Dr Green said that in addition to
other
prescriptions, she prescribes it to her patients to treat migraines.
She said
it does make her patients feel better. She said she uses it as a
preventive
measure for patients who experience 14 migraines or less per month.
'Prevention
then becomes imperative for many of these patients, and while there are
a slew
of prescription medications we can use for prevention, increasingly
people are
looking for alternatives,' Dr Green said. Rissetto said other health
benefits
associated with curcumin includes, a boost in brain function and a
lower risk
of developing brain diseases like Alzheimer's disease. A
2008
study published in the Annals of Indian Academy of Neurology found that
curcumin decreased Beta-amyloid plaques, which is a hallmark of
Alzheimer's.
She said it has also been linked to improved heart function. Spice is
able to
prevent dementia Siv Times, April
2018
Curcumin is a component of well-known condiments, recently conducted a
lot of
research about its positive and negative effects on health, reports the
Chronicle.info with reference to ladyhealth.com.ua. Scientists from
Israel have
also contributed, showing that curcumin helps to maintain brain health
and
reduces the risk of development of Alzheimer’s and Parkinson’s.
Scientists
from an Israeli hospital Hadassah has tested the potential of dietary
supplements to strengthen the intestinal cells to prevent uncontrolled
leakage
of intestinal contents into the bloodstream. In combination with
phospholipids,
curcumin showed anti-inflammatory properties, ability to reduce the
intervals
between the cells and make the intestines less permeable. The
disadvantage of
curcumin is rapid decomposition and removal within two hours. However,
its
positive effect lasts for 72 hours even after complete removal. Key
curry
ingredient could have amazing health benefits – and improve memory
Mirror,
April
2018
Curcumin has been analysed in a study published in the American Journal
of
Geriatric Psychiatry. Scientists at the University of California in Los
Angeles
examined the effects of the ingredient on people with mild and
age-related
memory loss. "Exactly how curcumin exerts its effects is not certain,
but it
may be due to its ability to reduce brain inflammation, which has been
linked
to both Alzheimer's disease and major depression," said Dr. Gary Small,
study
author and the director of geriatric psychiatry at UCLA's Longevity
Center. In
total, 40 participants aged between 50 and 90-years-old, each with mild
memory
loss and/or complaints, were brought in. Half were assigned 90
milligrams of
curcumin twice daily for 18 months; the rest were given a placebo.
Researchers
found that those who took curcumin saw improvement in both memory and
mood. The
substance levels in their blood was monitored, while cognitive
assessments and
PET scans were undertaken too. The study says that memory tests show
people
taking curcumin improved by as much as 28 per cent over the timeframe.
Their
overall disposition also improved, according to scientists. The
university
plans to continue its research and conduct a second study with a
greater number
of participants. Also to be explored is whether curcumin works better
in
certain ages, its impact on those with a genetic risk of dementia, and
if it
can be used to treat people with depression. Dr Small said: "These
results
suggest that taking this relatively safe form of curcumin could provide
meaningful cognitive benefits over the years." Fighting for those who
fought
The Batt, April
2018
The study, funded by the Department of Veteran Affairs (VA) and the
Department
of Defense, focused on a curcumin, a component of turmeric. Turmeric is
a spice
found in curry and has many health benefits that could help with the
disease
long term. The spice has been used in animal models and has shown signs
of
reversing GWI. “We were very pleased in our tests that curcumin
showed better
signs of reactions among animals than the true control group,†Shetty
said.
“That can lead us to believe there is good ahead in or long road of
discoveries and studies.†Can Turmeric Bring the Fight to
Mesothelioma?
Asbestos.com April
2018
There are two aspects to the
2017
turmeric and mesothelioma experiment. In both parts, the researchers
focused on
curcumin, a substance found in abundance in turmeric. First, they
studied how
curcumin curbs cell growth in mesothelioma cancer. The researchers
found the
spice component thwarted mesothelioma. Next, researchers examined how
curcumin
protected mice against mesothelioma tumor development. Compared with
the mice
who received plain corn oil, the mice who received the intraperitoneal
curcumin
and corn oil mixture: Experienced reduced risk of developing tumors
overall,
Developed fewer tumors, Had much smaller tumors, Lived significantly
longer.
Add turmeric to your diet to improve your well-being The Gauntlet,
April
2018
Kris Gunnars of the health-care blog Authority Nutrition says that
turmeric is
rich in a powerful anti-inflammatory called curcumin. Gunnars says that
curcumin is equally as effective at fighting inflammation as
pharmaceuticals
— but without the nasty headaches and stomach pain that they
typically cause.
Why Turmeric Is Good For High Blood Pressure NDTV, April
2018
Turmeric is popular for its antioxidant curcumin which helps in
lowering blood
pressure. Its antioxidant properties are the responsible for regulating
blood
pressure in the body. Curcumin also protects against vascular
dysfunction in
the body. Having high blood pressure in this case, causes further
damage to
tissues in arteries. LDL (or bad) cholesterol begins to deposit in
arteries in
the form of plaque in the walls of arteries. Curcumin in turmeric can
help in
preventing further damage caused to arteries because of high blood
pressure.
The anti-inflammatory property of turmeric is another reason which
contributes
to the popularity of the spice. Curcumin has anti-inflammatory
properties which
help in keeping hypertension at bay. Inflammation in the body is risky
because
it can contribute to stiffness in heart's arteries - which in turn may
raise
blood pressure. Consuming turmeric regularly can help in keeping blood
pressure
under control. Focus on Fitness: Boosting memory and avoiding obesity
Plant
City Observer, April
2018
Scientists at UCLA worked with 40 volunteers, age 50 through 90, who
all had
memory loss complaints. Their study, published in January in the
American
Journal of Geriatric Psychiatry, found using curcumin twice a day for
18 months
improved memory and mood tests, as well as brain scans. Curcumin is the
active
ingredient in the Indian spice turmeric. Besides cooking applications,
turmeric
has been used by ancient cultures for brain health for many centuries.
Turmeric
gives Indian curry its color and flavor. Manufacturers often use
turmeric to
color cheese, butter and prepared mustard. Known as a powerful
antioxidant,
curcumin scavenges free radicals in the human body to stop cell
membrane
damage. Curcumin lowers inflammation by reducing the enzymes that cause
it.
Chinese and Ayurvedic medicine systems also use turmeric to treat
digestive and
liver conditions as well as wounds and skin diseases. If you decide to
take
curcumin vitamin capsules, select a quality product from a reputable
manufacturer. Arthritis symptoms, spice could prevent joint pain
Express, April
2018
One compound within the spice - curcumin - has pain-relieving
characteristics
that may help to relieve arthritis suffering. Curcumin is also one of
the most
effective anti-inflammatory compounds in the world, researchers said.
The
compound may even be beneficial for Alzheimer’s disease patients.
Turmeric is
a yellow powder that works an an anti-inflammatory, scientists have
claimed.
One compound within the spice - curcumin - has pain-relieving
characteristics
that may help to relieve arthritis suffering. Curcumin is also one of
the most
effective anti-inflammatory compounds in the world, researchers said.
“While
arthritis cannot be cured, it seems that a high dose of curcumin can be
just as
[or more] effective than at least the most common medication prescribed
for the
condition. “Turmeric comes from India and other Southeast Asian
countries.
The dried root of the Curcuma longa plant is ground into the
distinctive yellow
turmeric powder. “The best part about turmeric? Not only is it
well-researched, incredibly potent and historically significant, it’s
also
safe.†Curcumin Suppresses IL-1β Secretion and Prevents Inflammation
Journal
of Immunology, April
2018
Turmeric is traditionally used as a spice and coloring in foods.
Curcumin is
the primary active ingredient in the turmeric, and compelling evidence
has
shown that it has the ability to inhibit inflammation. We report that
curcumin
inhibited caspase-1 activation and IL-1β secretion through suppressing
LPS
priming and the inflammasome activation pathway in mouse bone
marrow–derived
macrophages. The inhibitory effect of curcumin on inflammasome
activation was
specific to the NLRP3, not to the NLRC4 or the AIM2 inflammasomes.
Curcumin
inhibited the NLRP3 inflammasome by preventing K+ efflux and disturbing
the
downstream events, including the efficient spatial arrangement of
mitochondria,
ASC oligomerization, and speckle formation. Reactive oxygen species,
autophagy,
sirtuin-2, or acetylated α-tubulin was ruled out as the mechanism by
which
curcumin inhibits the inflammasome. Importantly, in vivo data show that
curcumin attenuated IL-1β secretion and prevented high-fat
diet–induced
insulin resistance in wide-type C57BL/6 mice but not in Nlrp3-deficient
mice.
Curcumin also repressed monosodium urate crystal–induced peritoneal
inflammation in vivo. Taken together, we identified curcumin as a
common NLRP3
inflammasome activation inhibitor. Our findings reveal a mechanism
through
which curcumin represses inflammation and suggest the potential
clinical use of
curcumin in NLRP3-driven diseases. Turmeric linked to avert the risk of
cardiovascular diseases, the recent study claims AskTelegraph.com March
2018
Benefits of curcumin: Curcumin has anti-inflammatory, anti-allergic,
anti-microbial, and antioxidant properties that help in blood clotting.
It can
act as a substitute for aspirin. Helps in treating of bone or joint
disorders
such as arthritis, osteoarthritis and rheumatoid arthritis at the
faster rate.
It also helps in fighting against skin infections and skin disorders.
“Clinical trials reveal that consuming 4 grams of turmeric
continuously for 4
days before surgery and 5 days’ post-surgery can reduce the risk of
myocardial infarction and chances of by-pass surgery by 56 percent as
compared
to placeboâ€, discloses Natural Medicines Database. Since curcumin
compound
found in turmeric has antioxidant properties, it can help in the
oxidation of
vital body parts thus dropping the chances of deadly cancer.
Additionally,
consuming 1.4 grams of turmeric on daily basis can help to thwart
low-density
lipoprotein (LDL), total cholesterol, triglyceride and very low-density
lipoprotein (VLDL) cholesterol in individuals. How this spice can give
you an
added health boost Belfast Telegraph, March
2018
Researchers have found that curcumin, the bright yellow chemical
produced by
turmeric, is capable of interacting with a variety of molecules
involved in
inflammation, easing swelling, aches and pains in the joints and
muscles. In
fact, a study published in the National Center for Biotechnology
Information
found that cucurmin may be just as effective as aspirin and ibuprofen
at
suppressing the body’s inflammatory response. As well as bolstering
the
body’s natural antioxidant function by increasing glutathione levels,
studies
found curcumin’s molecular structure can neutralise harmful free
radicals in
the body, lessening the chances of disease. Multiple studies have found
that
the yellow pigment in turmeric root can help to maintain the function
of the
interior lining of your blood vessels. One study published in the
Nutrition
Research journal in
2012
even found that curcumin may be as effective in improving vascular
function in
post-menopausal women as a moderate exercise routine. Turmeric
component may
ease Gulf War illness for vets Futurity March
2018
We found the individuals with GWI treated with curcumin for 30 days
showed
better cognitive function and mood than the control group did.†The
improvements were more than just functional. “Curcumin treatment
helped in
alleviating the brain inflammation seen in GWI,†says first author
Maheedhar
Kodali, a postdoctoral fellow. “It also enhanced the expression of
genes that
encode for antioxidants and normalized the expression of genes related
to the
function of mitochondria in the hippocampus.†“Particularly, the
ability of
curcumin to reduce the occurrence of activated microglia, a sign of
eased brain
inflammation, is remarkable,†Shetty says. The compound also seemed
to
enhance the formation of new neurons in the hippocampus, the part of
the brain
responsible for learning, memory, and mood and the region where new
neurons are
added throughout life in normal individuals. Could a spice be the key
to
helping Gulf War Illness vets? KCEN TV, March
2018
"Curcumin has been known to have antioxidant, anti-inflammatory and
neurogenic
properties, so that's why we thought it's a good candidate for
testing," Shetty
said. Doctor Shetty said, based on their recent studies, the bright
yellow
chemical in the spice is shown to improve cognitive function, reduce
brain
inflammation and act as an antioxidant. He went on to say it helped
create new
neurons in the brain. There is not one specific treatment for Gulf War
Illness
at this time. "We tested the efficacy of circumin immediately after the
exposure to Gulf War illness-related chemicals. And we found the
animals can
maintain better cognitive function and reduce depressor-like behavior,"
Shetty
said. The scientist went as far to say curcumin may even have the
potential to
prevent Alzheimer's disease, according to recent studies. Curcumin
treatment
leads to better cognitive and mood function in a model of Gulf War
Illness with
enhanced neurogenesis, and alleviation of inflammation and
mitochondrial
dysfunction in the hippocampus Science Direct, March
2018
This study showed that curcumin can mediate anti-inflammatory,
antioxidant,
neurogenic, and cognitive and mood enhancing effects in a condition
such as
GWI,†Shetty says. The findings correspond well with those of a
separate
study in humans from the University of California, Los Angeles, which
recently
showed curcumin improved the cognitive function of older adults by 28
percent.
Curcumin maintains better cognitive and mood function in a model of
Gulf War
Illness. Curcumin alleviates neuroinflammation in a model of Gulf War
Illness.
Curcumin enhances hippocampal neurogenesis in a model of Gulf War
Illness.
Curcumin normalizes mitochondrial function in a model of Gulf War
Illness.
Curcumin enhances the expression of genes that encode antioxidant
activity.
Eating Healthy And Natural May Keep Cancer At Bay NDTV, March
2018
Curcumin, an active compound found in turmeric may help keep cancer at
bay to a
certain extent. Curcumin helps inhibit the growth of various cancer
cells in
most parts of the body. It is known to have anti-cancerous properties.
Natural
supplements to stop lower back pain Express, March
2018
Turmeric is the spice that gives curry its yellow colour. It contains
the
anti-inflammatory compound curcumin, that could help to relieve a
painful back.
Try taking up to 1,000mg of turmeric supplements everyday to reduce
pain.
“Turmeric contains curcumin, which is the active ingredient that has
powerful
anti-inflammatory abilities, anti-aging effects and reduces pain.â€
Eating
Curry May Improve Memory and Happiness, New Study Says Newsweek, March
2018
The study was also double-blind, which means neither the doctor nor
patient
knew whether they were taking a placebo or the curcumin supplement. The
participants received cognitive tests at the beginning of the study
every six
months and blood tests that monitored their curcumin levels. Memory
improved by
28 percent over the course of 18 months among participants taking
curcumin.
There were mild improvements in mood, too, and brain scans revealed
fewer signs
of amyloid and tau, which are two abnormal proteins that form clumps in
the
brains of patients with Alzheimer's disease. The secret behind Julianne
Hough's
white teeth is common household spice turmeric Business Insider, March
2018
Turmeric has a key component called curcumin, which is a natural
anti-inflammatory that clears bacteria. Turmeric itself has been around
for a
very long time. It’s the spice that gives curry its color and Indians
have
been using it as a cooking aid and medicinal herb for thousands of
years. What
makes it so beneficial to our bodies is its key component: curcumin,
which is a
natural anti-inflammatory that repairs damage and clears away bacteria.
Curcumin prevents strokes in stroke-prone spontaneously hypertensive
rats by
improving vascular endothelial function BMC Cardiovascular Disorders,
March
2018
Administration of curcumin significantly delayed the onset of stroke
and
increased the survival of SHRsp, which was ascribed to decreased ROS
and
improved endothelial dependent relaxation of carotid arteries. In the
presence
of UCP2 inhibitor genipin, both curcumin-mediated decrease of ROS and
increase
of NO production were blocked. Our study suggests that curcumin exerts a
stroke
preventive effect by attenuating oxidative stress to improve vascular
endothelial function, which might be associated with UCP2 signaling.
Curcumin
shows promise for treating Gulf War illness Tamhsc.edu, March
2018
Turmeric, a spice commonly found in curry, has long been touted for its
health
benefits. Now, evidence in animal models suggests that one of its
components,
called curcumin, may be able to reverse some of the effects of Gulf War
illness
(GWI), according to recent research published in the journal Brain,
Behavior,
and Immunity. This research was funded by the Department of Veterans
Affairs
and the Department of Defense. Reasons why turmeric is scientifically
good for
you TV3, March
2018
Researchers have found that curcumin, the bright yellow chemical
produced by
turmeric, is capable of interacting with a variety of molecules
involved in
inflammation, easing swelling, aches and pains in the joints and
muscles. In
fact, a study published in the National Center for Biotechnology
Information
found that cucurmin may be just as effective as aspirin and ibuprofen
at
suppressing the body’s inflammatory response. As well as bolstering
the
body’s natural antioxidant function by increasing glutathione levels,
studies
have found curcumin’s molecular structure can even neutralise harmful
free
radicals in the body, lessening the chances of disease. One study
published in
the Nutrition Research journal in
2012
even found that curcumin may be as effective in improving vascular
function in
post-menopausal women as a moderate exercise routine. Research has
shown that
curcumin has a similar effect as antidepressants on patients suffering
from
depression, mood swings and anxiety, and studies on mice found that
daily doses
of turmeric can even increase the amount of happy hormones (serotonin
and
dopamine) in the brain. Curcumin inhibits superoxide dismutase-induced
epithelial-to-mesenchymal transition via the PI3K/Akt/NF-κB pathway in
pancreatic cancer cells International Journal of Oncology, March
2018
Curcumin is a natural polyphenol compound derived from turmeric. It
possesses
multiple pharmacological properties, including antioxidant,
anti-inflammatory
and anti-tumor progression properties. To summarize, these results
demonstrated
that curcumin was able to prevent SOD-driven H2O2-induced pancreatic
cancer
metastasis by blocking the PI3K/Akt/NF-κB signaling pathway. The use
of
curcumin to inhibit the H2O2/Akt/NF-κB axis may be a promising
therapeutic
approach to the treatment of patients with pancreatic cancer. Natural
Ways to
Help Prevent Alzheimer’s Disease Care2, March
2018
Research shows that the compound curcumin, found in the curry spice
turmeric,
not only protects the brain against memory loss, it may even help to
protect it
against Alzheimer’s disease. Curcumin is the plant nutrient that
gives
turmeric its golden-yellow hue. It turns out this vibrant compound also
holds
tremendous promise against serious brain disease by preventing the
formation of
beta amyloid plaques, which are involved in Alzheimer’s.
Alzheimer’s
patients with severe symptoms, including dementia, irritability,
agitation,
anxiety and apathy, have shown excellent therapeutic results when
taking
curcumin, according to a study published in the Japanese medical
journal Ayu.
Curry ingredient more effective than paracetamol at easing painful
injuries
Guardian, March
2018
Turmeric is more effective than popular painkillers at easing the agony
of
sports injuries, new research suggests. After less than three weeks,
taking a
key component of the Indian staple spice, known as curcumin, eases
injured
rugby players’ discomfort just as much paracetamol or ibuprofen, but
without
their side effects, a study found. Those opting for medication over the
curry
ingredient are four times more likely to suffer gastro-related
complications,
the research adds. This study suggests the naturally-derived,
curcumin-based
product could represent a promising safe, analgesic remedy in painful
osteo-muscular conditions associated with intense, high impact,
physical
activities. Turmeric is more effective than paracetamol or ibuprofen at
healing
injuries Deccan Chronicle, March
2018
A new study now suggests that turmeric is more effective than popular
painkillers at easing the agony of sports injuries. The study found
that after
less than three weeks, taking a key component of the Indian staple
spice, known
as curcumin, eases injured rugby players' discomfort just as much
paracetamol
or ibuprofen, but without their side effects.. The researchers further
believe
that curcumin may also benefit sufferers of inflammatory conditions,
such as
arthritis patients, without causing the complications associated with
many
existing treatments. Results further reveal those taking curcumin are
more
likely to stick to their treatment regimen. The researchers analysed 50
rugby
players from the Italian premier Piacenza club south of Milan who were
suffering bone or muscle problems as a result of incidents, such as
repeated
tackling. Half of the study's participants were given the one gram
curcumin-extract tablet Algocur, which is known as Turmeric+ in the UK,
twice a
day for up to 10 days. The remainder took painkillers. The findings
were
published in the European Review for Medical and Pharmacological
Sciences
journal. This comes after research released last month suggested
turmeric may
boost people's memories by nearly 30 per cent, as well as easing
depression.
Taking curcumin causes people to have significantly less protein
build-up in
the regions of the brain associated with memory and emotion, a study
found.
Past studies have also linked the onset of Alzheimer's disease to the
accumulation of protein plaques in the brain. Curcumin, which gives
turmeric
its yellow color, is thought to improve memory and boost mental health
due to
its anti-inflammatory properties. Inflammation has previously been
linked to
both dementia and severe depression. Curry ingredient turmeric is MORE
effective than paracetamol or ibuprofen at easing painful injuries,
study finds
Daily Mail, March
2018
Indian spice staple eases discomfort just as much as paracetamol or
ibuprofen.
Yet its key component curcumin does not cause their gastro side
effects.
Curcumin is a safe alternative to drugs after intense, high-impact
exercise.
Inflammatory-condition sufferers, like arthritis patients, may also
benefit.
Curcumin has been used as a herbal remedy in arthritis and heart
disease.
Curcumin differentially affects cell cycle and cell death in acute and
chronic
myeloid leukemia cells Oncology Letters, March
2018
Curcumin is a phytochemical with potent anti-neoplastic properties. The
antitumoral effects of curcumin in cells derived from chronic or acute
myeloid
leukemia have been already described. In conclusion, curcumin elicits
different
cellular mechanisms in chronic or acute myeloid leukemia cells and the
powerful
antitumoral effect was more potent in K562 compared with HL-60 cells.
Herbal
cures for uterine fibroids Guardian, March
2018
The results showed the mean diameter of leiomyoma were statistically
different
at before and after three and six month’s curcumin intake. And both
mean
volume of leiomyoma was statistically different at before and after
three and
six month’s curcumin intake. Adverse effect of curcumin was not
found. Also,
Egyptian researchers have successfully used turmeric, in clinical
studies, to
decrease the volume of uterine fibroids in women. The study published
in
Journal of American Science is titled “Curcumin a New Modality for
Treatment
of Uterine Myoma.†The results of the study found statistically
significant
decrease in the uterine volume and myoma volume (cm3), “again we find
statistically significant increases in Hb percentage after treatment
the
bleeding stop completely in 88 per cent after two weeks treatment and
after
four weeks in 12 per cent of the cases.†The researchers concluded:
“Curcumin is a new drug with multiple pharmacological actions, no
reported
side effects of significances for treatment of myoma.†Also, another
study
published in Gynecological Endocrinology showed curcumin suppressing
fibroid
cell replication by interacting with Peroxisome Proliferator-Activated
Receptor-Gamma (PPARg). PPARg is a cell receptor that plays a role in
controlling the cell cycle and cell division. It also has been found to
suppress inflammation. Nutritionist Says Everyone Over 30 Should Be on
These
Supplements New Beauty, March
2018
“I love CoQ10 and a curcumin—they're both antioxidants, so they
work great
if you’re looking to anti-age,†LeVeque says. “CoQ10 is known to
help
mitochondrial health and boost cellular energy, and as we age, you want
to keep
your mitochondria working efficiently because they're the energy
powerhouse
inside every cell in your body.†Additionally, coQ10 can protect skin
against
environmental stressors and free radicals, deterring any damage that
can
accelerate the aging process. “Curcumin—another good option—is
the active
ingredient inside turmeric and super anti-inflammatory,†adds
LeVeque.
Furthermore, curcumin has been proven to have a few under-the-radar
health
perks; most notably that it might be able to reduce the risk of
Alzheimer’s.
Know the various health benefits of everyday spices and herbs Review
Online,
March
2018
Turmeric. This yellow spice gets a lot of hype, and for good reason.
It’s a
good source of curcumin, an antioxidant that eases inflammation.
Research
suggests curcumin may help ease pain and lower the chances of heart
attacks.
Other research shows eating even small amounts of turmeric regularly
may help
prevent or slow down Alzheimer’s disease, possibly by helping prevent
the
brain plaques that lead to dementia. Curcumin induces apoptosis and
inhibits
proliferation in infantile hemangioma endothelial cells Medicine, March
2018
Curcumin has been used as an alternative medicine for the treatment of
infantile hemangiomas (IHs). We found that curcumin potently inhibited
proliferation in HemECs, achieving low-micromolar IC50 (the half
maximal
inhibitory concentration) value. We also observed that treatment with
curcumin
induced apoptosis in HemECs, as evidenced by positively Annexin-V-FITC
staining, caspase-3 activation, and cleavage of poly(adenosine
diphosphate-ribose) polymerase (PARP) in the treated cells. Moreover,
we showed
that curcumin suppressed the expression of antiapoptotic protein
myeloid cell
leukemia-1 (MCL-1), hypoxia-inducible factor 1α (HIF-1α), and
vascular
endothelial growth factor (VEGF).Altogether, our study suggests that
the
effectiveness of curcumin in IHs may be associated with its potent
antiproliferative and apoptotic activities in HemECs. Turmeric Can Help
Prevent
Heart Attacks, Doctor Says Tech Times, March
2018
"The main active ingredient in turmeric is curcumin and it's used as an
antioxidant, anti-inflammatory and has some action as an antiplatelet
agent
that can slow blood clotting, in a similar but more gentle way than
aspirin,"
said Cotterel. Aspirin has also been used to help prevent heart
attacks. Dr.
Cotterel expressed turmeric can be used similarly, although there are
no
clinical trials to back up this up other than in people who have just
gotten
coronary artery bypass grafts. "Clinical research suggests that taking
the
turmeric constituent, curcuminoids, 4 grams daily beginning 3 days
prior to
surgery and continuing for 5 days post-surgery can decrease the
relative risk
of myocardial infarction following coronary artery bypass grafting by
approximately 56 percent compared to placebo," according to the Natural
Medicines Database. Turmeric's anti-inflammatory effects can help
reduce joint
pain, osteoarthritis, and may help pain related to rheumatoid
arthritis.
"Curcumin is another great way to get a higher dose of it so if used
therapeutically, it's best to do for arthritis. You wouldn't overdose
on it,"
said Dr. Cotterel. "Since it is an antioxidant, the spice can be
sometimes used
to help prevent some of the diseases associated with oxidation in the
body such
as cancer. It has also been found to be effective in itching from
various
sources," said Dr. Cotterel. In addition, other research suggests
taking
turmeric extract at 1.4 grams/day orally in two different doses over 3
months
have the ability to reduce levels of total cholesterol, low-density
lipoprotein
(LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and
triglyceride in patients aged 15-45 years-old. Curcumin may serve an
anticancer
role in human osteosarcoma cell line U-2 OS by targeting ITPR1 Oncology
Letters, March
2018
Treatment with curcumin was able to significantly increase the levels
of CLTC
and ITPR1 mRNA in curcumin‑treated cells compared with control. In
addition,
targeting ITPR1 with curcumin significantly promoted apoptosis and
suppressed
proliferation, migration and invasion. Targeting ITPR1 via curcumin may
serve
an anticancer role by mediating apoptosis, proliferation, migration and
invasion in U-2 OS cells. Turmeric Could Help Treat Endometriosis, Says
Study
Womens Health, March
2018
A review of relevant studies published in the journal Biomedicine &
Pharmacotherapy, examined the effect that curcumin, a compound found in
turmeric, has on the disease. Results of in vitro and animal studies
showed
that curcumin reduced pain and inflammation through the suppression of
inflammatory cytokines expression. It was also found to repress the
invasion,
attachment, and angiogenesis of endometrial lesions, inhibiting the
disease's
progression. Curcumin and endometriosis: Review on potential roles and
molecular mechanisms Science Direct, March
2018
Turmeric, an important spice all around the world, is obtained from the
rhizomes of Curcuma longa, a member of the Zingiberaceae family. It has
been
used in the prevention and treatment of many diseases since ancient
times.
Curcumin is the principal polyphenol isolated from turmeric. Several
evidences
have shown the anti-inflammatory, antioxidant, anti-tumor,
anti-angiogenesis,
and anti-metastatic activities of curcumin. In this review, relevant
articles
on the effect of curcumin on endometriosis and possible molecular
mechanisms
are discussed. The results of related in vitro and animal studies have
shown
that treatment with curcumin reduces inflammation through suppression
of
inflammatory cytokines expression. It also can inhibit invasion,
attachment,
and angiogenesis of endometrial lesions. Moreover, curcumin inhibits
cell
proliferation and causes cell cycle arrest and apoptosis. Thus, it may
has
potential benefits as a dietary and pharmacological agent for the
prevention
and treatment of endometriosis. Turmeric is great, but look for
curcumin Herald
Dispatch, March
2018
Finding a high-potency curcumin supplement can unfortunately be tougher
than it
sounds. Curcumin only occurs at a pretty low percentage in standard
turmeric
powder, somewhere roughly between 2 to 4 percent by weight. Many
products on
the market will claim to be "turmeric with curcumin." That sounds
great, but
doesn't really mean much, being that all turmeric contains curcumin.
Instead of
a somewhat vague label claim, pay attention to the supplement facts
panel to
see what percentage of curcumin is guaranteed per serving. The
most-studied
curcumin products on the market can range anywhere from 30 to 95
percent
curcumin. It is also a pretty common trick to see a product claiming
"made with
95 percent curcumin" on the front of the bottle, but after a glance at
the
supplement facts, it may only use a small amount of that curcumin
extract in a
base of regular turmeric powder. The high-potency extraction process
takes a
lot of raw material, therefore quality supplements can be a little on
the
expensive side. In certain curcumin supplements, one capsule can equal
the
absorption of up to 500 regular turmeric powder capsules, so it can be
worth
the extra price for the extra potency. Curcumin inhibits hepatocellular
carcinoma growth by targeting VEGF expression Oncology Letters, March
2018
Curcumin is a polyphenol compound that has been demonstrated to exert
effective
antiangiogenic, anti‑inflammatory, antioxidant, and antitumor
effects.
Curcumin treatment inhibited H22 cell proliferation and promoted H22
cell
apoptosis in a dose‑dependent manner in vitro. In addition, curcumin
treatment inhibited tumor growth in vivo at the concentrations of 50
and 100
mg/kg. Furthermore, curcumin treatment significantly decreased VEGF
expression
and PI3K/AKT signaling. The present findings demonstrated that curcumin
inhibited HCC proliferation in vitro and in vivo by reducing VEGF
expression.
Turmeric helps eliminate depression, alleviate pain, slow the aging
process,
protect the digestive tract, and prevent cancer Pulse, March
2018
As a matter of fact, a number of laboratory studies on cancer cells
have shown
that curcumin, which is the principal curcuminoid of turmeric, does
have
anticancer effects. It has been observed to have the ability to kill
cancer
cells as well preventing more from growing. In addition, turmeric also
has the
best effects on breast cancer, bowel cancer, and stomach cancer and
skin cancer
cells. And curcumin, which is the principal curcuminoid of turmeric,
happens to
be a potent antioxidant that neutralizes free radicals due to its
chemical
structure as well as boosting the activity of the body's own
antioxidant
enzymes. Study backs daily consumption of curcumin for your memory,
mood
Jakarta Post, March
2018
The research study involved 40 adults aged between 50 and 90 years old
who
experience "mild memory complaints." They were randomly given "either a
placebo
or 90 mg of curcumin" twice a day. After 18 months, those who consumed
curcumin
were reported to experience "significant improvements in their memory
and
attention abilities," while those who were given the placebo did not.
In
addition to a 28 percent increase in their memory, the curcumin group
were also
found to enjoy "mild improvements in mood." “These results suggest
that
taking this relatively safe form of curcumin could provide meaningful
cognitive
benefits over the years,†said Small. Turmeric and Curcumin Pop
Sugar, March
2018
Curcumin is the most active ingredient in turmeric. It's the chemical
compound
that naturally occurs in turmeric. Curcumin makes up 2 percent to 6
percent of
the turmeric spice found in your cabinet, according to Andrew Weil, MD.
In
fact, curcumin gives turmeric its distinct yellow color. That color is
passed
on to curry, since turmeric is a main ingredient in that spice. But
curcumin
isn't just part of spices; it has powerful health benefits all its own,
such as
being an antioxidant and having antitumor properties. In addition, at
least one
study has found that curcumin can be effective as a treatment for
depression.
Even more recently, a
2018
study from UCLA found that curcumin can help improve mood and memory
loss.
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supported.
Just like turmeric, curcumin also has anti-inflammatory properties,
making it a
viable way to ease arthritis pain and discomfort. It also can ease
muscle
soreness after a workout, help you sleep better, and combat bloating.
If those
aren't enough benefits for you, in an animal study, curcumin was shown
to
prevent fat tissue growth. There's also a parallel between curcumin and
the
prevention of cardiovascular diseases, diabetes management, and
protection from
cancer, and it can be used as a therapeutic aid with gastrointestinal
issues,
like ulcerative colitis. Turmeric could improve memory The Chronicle
Herald,
March
2018
A new study published late January in the American Journal of Geriatric
Psychiatry investigated the effect of a highly-absorbable curcumin
supplement
on the memory of healthy people with mild memory complaints. This study
also
examined the effect of this curcumin supplement on the plaques and
tangles
which form in the brains of people with Alzheimer’s disease. This
study was
small with just 40 subjects between the ages of 50 to 90 years old. All
study
participants were randomly given either daily placebo or a highly-
absorbable
curcumin supplement over the course of the 18-month study. By the end
of the
18-month study, the people who took the curcumin supplement were found
to have
improved memory and mood compared to those who took the placebo. The
memory
tests administered by the researchers at the study’s end showed a 28
per cent
improvement in those taking the curcumin supplement, compared to those
taking
placebo. Additionally, Positron emission tomography (PET) brain scans
performed
at the end of the study showed a significant reduction in amyloid and
tau
signals in the amygdala and hypothalamus of the participants who took
the
curcumin supplement, compared to those who took the placebo. These two
markers
are important indicators of brain health and risk of developing
Alzheimer’s.
What does the evidence say about turmeric's health benefits? ABC, March
2018
It's not the spice itself that's key, rather it's an active compound
within
turmeric called curcumin. Research has found that curcumin has some
anti-oxidant and anti-inflammatory properties. "Curcumin is a very
powerful
anti-inflammatory agent," said Professor Manohar Garg, director of the
nutraceuticals research program at the University of Newcastle. Because
inflammation is linked to a range of chronic conditions and diseases,
among
them arthritis, Alzheimer's and heart disease, researchers argue
curcumin could
help reduce the risk of those diseases by limiting inflammation in the
body.
"It's very powerful, the most powerful food I know of, for fighting
inflammation in the body," Professor Garg said. Research conducted by
the
professor and his team found those people taking a combination of
curcumin and
a phytosterol (a naturally occurring steroid found in plants) reduced
their
cholesterol levels over a four-week period compared to a group who
received a
placebo. "There's some cholesterol-lowering effect from curcumin, and
some
cholesterol-lowering effect from phytosterols, but if you combine them
together
it's a synergistic effect. It's beyond what you expect from the two
compounds
separately," Professor Garg said. Other research into curcumin has
focused on
its potential to improve cognitive function, particularly in older
people. The
researchers found those in the group given curcumin supplements had
better
working memory and an improved mood while taking the cognitive tests
over a
28-day period. Professor Scholey said it was possible the curcumin was
improving blood flow to the brain in those who took the supplements.
"There is
some work showing that curcumin can improve what's called endothelial
function
— that refers to the cells that line blood vessels, which can be in
various
degrees of elasticity or stiffness," Professor Scholey said. Curcumin
May
Reverse Memory Problems, Improve Mood Forbes, March
2018
Memory function of those who’d taken curcumin improved by 28% on
average over
the 18 months. In contrast, the control group's scores rose slightly
(possibly
because they got more familiar with the tests) and then declined. The
depression scores of those taking curcumin also improved; the control
group's
didn't change. And interestingly, brain scans revealed significantly
less
amyloid and tau accumulation in two brain regions of the participants
taking
curcumin—the amygdala and hypothalamus, which control anxiety,
memory,
decision-making, and emotion. Best Foods That Could Calm The Symptoms
Of Acid
Reflux Inquisitr, March
2018
Turmeric contains anti-inflammatory and antioxidant properties. It also
has
curcumin, which is its most active ingredient. It is known that
curcumin has
antibacterial and anticancer properties. In a
2007
study, it indicated that GERD should be treated with antioxidants and
anti-inflammatories. In another study, it suggested that curcumin with
its
anti-inflammatory effects could prevent esophageal inflammation. Indian
spice
may help improve memory WNYT, March
2018
The spice turmeric, commonly used in Indian food, may help to improve
memory.
It's actually a compound within the spice called curcumin. Researchers
at UCLA
looked at 40 older adults with mild memory problems. Patients who took
curcumin
tablets for 18 months scored higher on memory tests and had fewer brain
plaques
than those who took a placebo. The curcumin group also reported small
improvements in mood. Experts believe curcumin may reduce brain
inflammation,
which has been linked to Alzheimer's disease and depression. New Study
Shows
Turmeric May Improve Brain Health Cooking Light, March
2018
Curcumin, the bright yellow polyphenol compound found in turmeric, has
been the
focus of research due to its potential to prevent chronic diseases such
as
cancer, heart disease, arthritis, diabetes, and Alzheimer’s disease.
Clinical
studies support curcumin’s anti-inflammatory and antioxidant effects
on
obesity and associated inflammation, leading to outcomes such as weight
loss,
improved blood lipids, reduced risk of atherosclerosis, and improved
insulin
sensitivity. Daily consumption of curcumin has been shown to improve
memory and
mood in people with mild, age-related memory loss, according to a study
by UCLA
that was recently published in the American Journal of Geriatric
Psychiatry.
Researchers examined the effects of curcumin supplements in people ages
51-84
who had mild memory complaints, but no dementia, as well as those ages
51-84
who were diagnosed with Alzheimer's disease. Participants took either a
placebo
or 90 milligrams of curcumin two times a day for 18 months. At the end
of the
experiment, PET scans determined those who took curcumin experienced
significant improvement in their memory, mood, attention span, while
those who
took the placebo did not experience any of these positive effects.
Researchers
have identified chronic infections and inflammation as major risk
factors for
various types of cancer. As such, regular consumption of turmeric has
been
touted as a possible contributor to lower cancer rates. Results from
several
studies suggest that curcumin may reduce tumor promotion, block cell
transformation, and minimize the spread of certain types of cancer.
Curcumin’s role in the treatment of arthritis also shows promise.
Studies
show that patients supplementing with curcumin had reduced arthritis
pain and
swelling due to the inhibition of COX-2 activity. This is typically
what NSAIDs
are prescribed for. Curcumin and derivatives function through protein
phosphatase 2A and presenilin orthologues Biologists.org March
2018
Curcumin, the main curcuminoid of turmeric, is a complex molecule
possessing
wide-ranging biological activities, cellular mechanisms and roles in
potential
therapeutic treatment, including Alzheimer's disease and cancer. Here,
we
investigate the physiological effects and molecular targets of curcumin
in
Dictyostelium discoideum. We show that curcumin exerts acute effects on
cell
behaviour, reduces cell growth and slows multicellular development.
Using in
silico docking analysis, we then showed that curcumin might function
through
direct binding to a key regulatory region of PsrA. These findings
reveal novel
cellular and molecular mechanisms for the function of curcumin and
related
compounds. Is Turmeric Good For You? Science Says It Can Improve Your
Memory,
So Eat Up Elite Daily, March
2018
Curcumin and turmeric are sometimes used interchangeably, but they
actually
aren’t the same thing. Turmeric is a spice, while curcumin is a
chemical
compound that is found in turmeric. In other words, curcumin can be
taken
separately from turmeric in supplement form, but turmeric doesn’t
exist
without curcumin. For example, in addition to improving memory,
turmeric yields
a decent amount of medicinal properties. According to Healthline,
curcumin is
also a strong antioxidant and contains anti-inflammatory properties. It
also
has been noted to potentially prevent heart disease by strengthening
blood
vessel lining. Curcumin May Help Improve Memory: Other Potential Health
Benefits Of This Turmeric Compound Tech Times, March
2018
The researchers found less signals of tau and amyloid proteins in those
who
were given curcumin supplements. These proteins are linked to the
development
of Alzheimer's Disease. "Exactly how curcumin may exert cognitive and
mood
effects is not certain, but several potential mechanisms could explain
our
findings," researchers wrote in their study. "Curcumin reduces
inflammation,
and heightened brain inflammation has been linked to both Alzheimer
disease and
major depression." Countries such as India, where people eat curcumin
at levels
of about 100 mg to 200 mg a day over long periods of time, have low
prevalence
of cancer. Researchers suspect this may have something to do with the
health
benefits of turmeric. Earlier studies have shown other possible
beneficial
effects of consuming curcumin on health. In a
2001
study involving patients with precancerous changes, investigators found
that
curcumin could stop precancerous changes in organs from developing into
cancer.
"Our results also suggest a biologic effect of curcumin in the
chemoprevention
of cancer," the researchers wrote in their study. Lab tests also showed
that
turmeric extract that contains curcumin may help stabilize colorectal
cancer
that did not benefit from other forms of treatment. Study says Increase
your
memory and mood by eating turmeric Week Facts, March
2018
Found in turmeric, curcumin is hailed as a mitigating with cancer
prevention
agent properties, and it has additionally been recommended as a
conceivable
reason that senior residents in India – where curcumin is to some
degree a
staple – have bring down rates of Alzheimer’s malady and better
psychological execution. The examination directed by the University of
California Los Angeles set out to inspect the impacts of the fixing on
individuals with mellow, age-related memory misfortune. “Precisely
how
curcumin applies its belongings isn’t sure, however it might be
because of
its capacity to lessen mind aggravation, which has been connected to
both
Alzheimer’s ailment and real sorrow,†said Dr. Gary Small. Is
Turmeric an
Effective Treatment for Endometriosis? Medical News Bulletin, March
2018
The spice turmeric, which contains the polyphenol curcumin, has long
been
thought to contain antioxidant and strong anti-inflammatory properties.
However, few studies have investigated the effects of curcumin on
endometriosis. In a recent study published in Biomedicine &
Pharmacotherapy,
researchers from Iran reviewed the effects. Studies Show Curcumin as
Generally
Safe and Effective The limited in-vitro and animal studies indicate
that
curcumin can reduce inflammation by suppressing inflammatory cytokine
expression. In addition, there is some evidence that curcumin may
reduce the
disease progression by inhibiting the invasion, attachment, and
angiogenesis of
endometrial lesions. Curcumin is generally recognized as safe to use by
the US
Food and Drug Administration, and studies have demonstrated its safety
up to at
least 15 mg per day. Dietary Curcumin Intervention Targets Mouse White
Adipose
Tissue Inflammation and Brown Adipose Tissue UCP1 Expression Obesity,
March
2018
Curcumin intervention reduced WAT macrophage infiltration and altered
macrophage functional polarity, as the ratio of M2-like versus M1-like
macrophages increased after curcumin intervention. Curcumin treatment
reduced
M1-like macrophage markers or proinflammation cytokine expression in
both
macrophages and adipocytes. Curcumin intervention also increased energy
expenditure and body temperature in response to a cold challenge.
Finally, the
in vivo and in vitro investigations suggested that curcumin increased
expression of uncoupling protein 1 (UCP1), possibly involving
PPAR-dependent
and -independent mechanisms. Curcumin intervention targets both WAT
inflammation and BAT UCP1 expression. These observations advanced our
knowledge
on the metabolic beneficial effects of the curry compound curcumin,
bringing us
a novel perspective on dietary polyphenol research. Molecular targets
of
Curcumin Advances in Experimental Medicine and Biology, March
2018
Curcumin possesses anti-inflammatory activity and is a potent inhibitor
of
reactive-oxygen-generating enzymes such as lipoxygenase/cyclooxygenase,
xanthine dehydrogenase/oxidase, and inducible nitric oxide synthase
(iNOS); it
is an effective inducer of heme oxygenase-1. t has been demonstrated
that
curcumin- induced apoptosis is mediated through the impairment of the
ubiquitin–proteasome pathway. Curcumin attenuates heat-stress-induced
oxidant
damage by simultaneous activation of GSH-related antioxidant enzymes
Academic.oup.com, March
2018
It was concluded that curcumin supplementation enhanced the resistance
of
broilers to heat stress, as evidenced by reversing the FC, increasing
the GSH
content and GSH-related enzyme activities, and inducing the expression
of Nrf2
and Nrf2-mediated phase II detoxifying enzyme genes. Dietary curcumin
may boost
egg quality, hen health Feed Navigator.com, March
2018
We can conclude that curcumin added in the diet of laying hens was able
to
increase egg antioxidant levels, as well as to reduce lipid
peroxidation in
fresh and stored eggs, contributing to the improvement of egg quality.
Moreover, the curcumin exerted beneficial effects on an animal health
by
stimulating the immune response and controlling coccidiosis. Dietary
curcumin
may boost fish survival, performance Feed Navigator.com, March
2018
Our results demonstrated that curcumin dietary supplement exerts potent
bactericidal action against S. agalactiae, presenting 100% of
therapeutic
efficacy when compared to infected and non-supplemented animals. Also,
the
treatment prevented the occurrence of clinical signs of disease. The
Surprising
Health Benefit Hiding In Turmeric, The bright yellow spice may help
protect
your brain, a new study finds Mens Health, February
2018
At the end of the study, the curcumin group experienced a 28 percent
improvement in their memory tests, while those popping the placebo
didn’t see
a significant change. What’s more, they also saw a slight boost in
their mood
compared to the placebo poppers. The researchers can’t say exactly
why
curcumin might have these effects. But after analyzing the brain scans,
they
noticed that people taking curcumin had lower levels of both abnormal
proteins,
specifically in areas of the brain that influence memory and emotion.
Plus,
curcumin is an antioxidant that might fight inflammation, explains
study author
Gary W. Small, M.D., director of the UCLA Longevity Center. The more
inflammation you have in your brain, the more likely you are to
experience
cognitive problems and depression, he says. Curcumin May Reverse Memory
Problems, Improve Mood Forbes, February
2018
With more and more of the aging population affected by Alzheimer's
disease, and
clinical trials for new medications often providing underwhelming
results, a
new study in The American Journal of Geriatric Psychiatry may be
especially
promising. It finds that taking a daily dose of curcumin, the compound
in
turmeric root that gives curry its yellow color, may not only prevent
memory
problems from worsening over time, but actually improve them. And
perhaps most
noteworthy, these changes were seen not only in the participants'
cognitive
capacities, but also in their brain cells. It turned out that the
memory
function of those who’d taken curcumin improved by 28% on average
over the 18
months. In contrast, the control group's scores rose slightly (possibly
because
they got more familiar with the tests) and then declined. The
depression scores
of those taking curcumin also improved; the control group's didn't
change. And
interestingly, brain scans revealed significantly less amyloid and tau
accumulation in two brain regions of the participants taking
curcumin—the
amygdala and hypothalamus, which control anxiety, memory,
decision-making, and
emotion. Is Turmeric Beneficial to Everyone? Dr. David Samadi Explains.
Reporter Expert, February
2018
Renowned surgeon David Samadi is enthusiastic about people using
turmeric to
improve their own health. Dr. Samadi is the chairman of urology and the
chief
of robotic surgery at New York City’s Lenox Hill Hospital. He is a
world
leader in using cutting-edge technology to treat cancer patients. At
the same
time, he is passionate about educating people about what they can do
for
themselves to live a healthy and vibrant life. To that end, he makes
frequent
appearances in the media to spread his knowledge to as many people as
possible.
Dr. Samadi is a member of the Medical A-Team on Fox News and is the
chief
medical correspondent on AM 970, a popular radio station serving the
New York
City metropolitan area. According to Dr. Samadi, turmeric may be
helpful in
treating or preventing arthritis, inflammatory bowel disease,
Alzheimer’s
disease, cancer and depression. He explains the science behind
turmeric’s
beneficial effects in treating the following common conditions:
Arthritis
Studies show that curcumin, the active ingredient in turmeric that has
anti-inflammatory properties, can help relieve the pain caused by joint
inflammation. Inflammatory Bowel Disease Studies show that curcumin
lowers the
rate of relapse for people suffering from ulcerative colitis, which is a
chronic form of inflammatory bowel disease. Alzheimer’s Disease
Research
shows promising results in using turmeric to help slow down the
progression of
this terrible disease. Scientists believe that curcumin may help
destroy the
plaque that causes Alzheimer’s patients to lose cognitive function.
Countries
where turmeric is frequently used in cooking have lower rates of
Alzheimer’s
disease. Cancer Research shows that curcumin may help reduce the spread
of
tumors in patients who have pancreatic and some other types of cancer.
It is
not a stand-alone treatment, but it may be useful as a supplement to
other
forms of treatment. Depression Several studies have shown that curcumin
can
help reduce the symptoms of depression. How to Use Turmeric for Your
Health If
you are not used to cooking with turmeric, you may wonder how to
incorporate it
into your daily life. You can buy turmeric as a whole root or in dried
and
powdered form. Both are good, but the dried form has a higher
concentration of
curcumin, the component of turmeric most often studied for its
anti-inflammatory health benefits. Dr. David Samadi points out that a
standard
dosage of turmeric hasn’t been established. However, he suggests that
one to
three grams per day of the dried form of turmeric is probably enough.
How to
Maximize the Absorption of Curcumin Dr. Samadi suggests that you
consume
turmeric when you are eating a meal. Taking turmeric with food helps
your body
better absorb the curcumin in the turmeric. You can help ensure you are
absorbing the maximum amount by ingesting turmeric while you are eating
a meal
that contains healthy fats. These fats include fish oil, olive oil,
avocado
oil, coconut oil, nuts and seeds. Turmeric Compound Boosts Cognitive
Power,
Reveals New Study Sci-News, February
2018
Curcumin has previously been shown to have anti-inflammatory and
antioxidant
properties in lab studies. It also has been suggested as a possible
reason that
senior citizens in India, where curcumin is a dietary staple, have a
lower
prevalence of Alzheimer’s disease and better cognitive performance.
“The
people who took curcumin experienced significant improvements in their
memory
and attention abilities, while the subjects who received placebo did
not,â€
Dr. Small said. “In memory tests, the people taking curcumin improved
by 28%
over the 18 months. Those taking curcumin also had mild improvements in
mood,
and their brain PET scans showed significantly less amyloid and tau
signals in
the amygdala and hypothalamus than those who took placebos.†Curcumin
limits
weight gain. Journal of Applied Physiology, February
2018
We investigated the effect of curcumin, a naturally occurring
polyphenol known
for its anti-inflammatory properties and inhibitory action on 11β-HSD1
activity, on preserving metabolic health and limiting adipose tissue
growth
following the cessation of daily exercise and caloric restriction (CR).
Cessation of daily CR and exercise caused an increase in body mass, as
well as
a 9- to 14-fold increase in epididymal, perirenal, and inguinal adipose
tissue
mass, all of which were attenuated by curcumin ( P < 0.05). Insulin
area under
the curve (AUC) during an oral glucose tolerance test, HOMA-IR, and
C-reactive
protein (CRP) were elevated 6-, 9-, and 2-fold, respectively, in the
Detrained
+ Placebo group vs. the Trained group (all P < 0.05). Curcumin
reduced insulin
AUC, HOMA-IR, and CRP vs. the placebo group (all P < 0.05). Our
results
indicate that curcumin has a protective effect against weight regain
and
impaired metabolic control following a successful period of weight loss
through
diet and exercise, perhaps via inhibition of glucocorticoid action and
inflammation. Lowering your risk of Alzheimer's disease Express,
February
2018
Memory loss could also be prevented by eating more curry, scientists
have
claimed. The spice curcumin - which gives curry its bright colour -
could boost
patients' mood and memory. Eating curcumin everyday for 18 months
improved
memory by 28 per cent, a study claimed. Natural supplements that you
should be
taking every day Blasting News, February
2018
Turmeric -- The spice that gives curry that yellow coloring. This
powerful
herb's main ingredient is curcumin, a natural anti-inflammatory which
the body
needs to fight off bacteria that are harmful. Along with the increased
production of antioxidants and a great way to fight heart disease,
another
important benefit of taking Turmeric is the growth hormone called
Brain-Derived
Neurotrophic Factor. According to the US National Library of Medicine,
decreased levels of BDNF can lead to brain disease and decreased
functions in
the brain. Curcumin can increase levels of BDNF, which can delay or
even
reverse many brain diseases or age-related decreases in brain function.
You
will want to add this to your supplement routine, as curcumin makes up
only
three percent of Turmeric, so taking it as a supplement is better.
Curcumin
Improves Mood and Memory Doctor Oz, February
2018
UCLA researchers find consumption of curcumin helps mood and memory.
Forty
adults with mild memory complaints were randomly selected to ingest
curcumin
twice daily or a placebo for 18 months. They underwent cognitive
assessments
and PET scans to test amyloid in the brain, which is associated with
negative
effects on memory and emotional functions. Those taking curcumin
improved their
memory tests by twenty-eight percent, demonstrated mild mood
improvements, and
showed far smaller levels of amyloid than the placebo group. A
follow-up study
will explore the possibility of curcumin possessing antidepressant
effects and
whether it can help your genetic risk for Alzheimer’s. These findings
back up
the far lower rate of Alzheimer’s in India’s senior citizens, whose
diet is
high in curcumin. Curry Ingredient May Improve Memory GKMan, February
2018
Participants who took curcumin experienced significant improvements in
their
memory and attention abilities, while the subjects who received placebo
did
not. Therefore it has been proven that curcumin can contribute to the
improvement of memory and disposition of people suffering from moderate
memory
loss cause by aging. A new study has been published, confirming that
curcumin,
the chemical that gives curry its intense yellow color, has important
health
benefits, in the context of long-term consumption. The healing power of
turmeric: Curcumin may lower Alzheimer’s disease risk by boosting
memory and
mood Times Now News, February
2018
Earlier, a report published in the British Medical Journal Case
Reports, noted
that a 57-year-old woman, who was diagnosed with blood cancer in
2007
after complaining of high blood pressure, curcumin helped her recover
from the
deadly condition after conventional medicine failed to work on her
body. The
report said the woman started taking 8g of curcumin a day - one of the
main
compounds in turmeric - as a last resort after research online. With no
further
treatment, over the last five years, doctors said her cancer had
remained
stable and her blood counts are within the normal range with daily
curcumin.
The findings revealed that people who took curcumin experienced
significant
improvements in their memory and attention abilities, while the
subjects who
received placebo did not. Turmeric is one of the most traditional and
versatile
of spices used in Indian cooking. It has been suggested as a possible
reason
that senior citizens in India have a lower prevalence of Alzheimer’s
and
better cognitive performance. Curcumin's Anti-Inflammatory Properties
Might
Improve Memory, Attention Ask Men, February
2018
Turmeric is on a tear right now. In recent years it’s been connected
to
everything from healthier skin to helping control pain and
inflammation. But
new research suggests it can also aid with memory and happiness. The
paper,
published last week in the American Journal of Geriatric Psychiatry,
examined
the effects of an easily absorbed supplement of curcumin — the
substance that
gives turmeric its bright orange colour — on the performance of
memory in
people without dementia. The study also looked at curcumin’s
potential impact
on the microscopic plaques and tangles that occur in the brains of
those with
Alzheimer’s disease. The heavy use of turmeric in cooking has already
been
raised as a possible reason for the lower rates of Alzheimer’s
disease and
better cognitive performances among senior citizens in India compared
to the
rest of the world. Why? Most likely because of its capacity to reduce
brain
inflammation, “which has been linked to both Alzheimer’s disease
and major
depression,†said the study’s author, Doctor Gary Small of UCLA, in
a news
release. The study involved a double-blind, placebo-controlled group of
40
adults between ages 50 and 90. They were Alzheimer’s and dementia
free, but
all reported mild memory complaints. The participants were randomly
assigned to
receive either a placebo or 90 milligrams of curcumin twice daily for
18
months. They were then monitored at six month intervals throughout the
test
using a standardized cognitive assessment. After 18 months, those who
had been
taking curcumin were reporting significant improvements in memory and
attention
abilities. On average, their memory tests improved by a whopping 28%.
The
curcumin takers also reported a slight improvement in mood when
compared to
those on the placebo. Striking with the Root: Turmeric Curcumin and
Ulcerative
Colitis Care2, February
2018
Despite evidence going back 40 years that the turmeric spice component
curcumin
possesses significant anti-inflammatory activity, it wasn’t until
2005
that it was first tested on inflammatory bowel disease. Why did it take
so
long? Well, who’s going to fund such a study? Big curry? Even without
corporate backing, individual physicians from New York decided to ask
the next
five patients with ulcerative colitis who walked through their office
doors to
start curcumin supplements. And, researchers obliged. They took a bunch
of
people with quiescent ulcerative colitis and gave them either turmeric
curcumin
along with their typical anti-inflammatory drugs, or a placebo and
their drugs.
In the placebo group, 8 out of 39 patients relapsed, meaning their
disease
flared back up. In the curcumin group, however, only 2 out of 43
relapsed,
significantly fewer. And, relapse or not, clinically, the placebo group
got
worse, while the curcumin group got better. Endoscopically, which is
objectively visualizing the inside of their colons, doctors saw the
same thing:
a trend towards worse or better. The results were stunning: a 5 percent
relapse
rate in the curcumin group compared with a 20 percent relapse rate in
the
conventional care group. It was such a dramatic difference that the
researchers
wondered if it was some kind of fluke. Even though patients were
randomized to
each group, perhaps the curcumin group just ended up being much
healthier
through some chance coincidence, so maybe it was some freak occurrence
rather
than curcumin that accounted for the results. So, the researchers
extended the
study for another six months but put everyone on the placebo to ensure
the
initial findings were not some aberration. The curcumin was stopped to
see if
that group would then start relapsing, too—and that’s exactly what
happened. Suddenly, they became just as bad as the original placebo
group. The
researchers concluded: “Curcumin seems to be a promising and safe
medication
for maintaining remission in patients with quiescent ulcerative
colitis.â€
Indeed, no side effects were reported at all. So, “Curry for the
cure?â€
asked an accompanying editorial in the journal of the Crohn’s and
Colitis
Foundation of America. “Can curcumin be added to our list of options
with
respect to maintaining remission in ulcerative colitis? What is
noteworthy
about this trial is the fact that not only did the authors demonstrate a
statistically significant decrease in relapse at 6 months, but a
statistically
significant improvement in the endoscopic index as well. Equally
telling is the
fact that upon withdrawal of curcumin the relapse rate quickly
paralleled that
of patients treated initially with placebo, implying that curcumin was,
in
fact, exerting some important biologic effect.†Similarly, a Cochrane
review
concluded in
2013
that curcumin may be a safe and effective adjunct therapy. Curcumin
Shown to
Improve Memory Whole Foods Magazine, February
2018
Results of the study are as follows: Memory function of those who’d
taken
curcumin improved by 28% on average over the 18 months. In contrast,
the
control group’s scores rose slightly (possibly because they got more
familiar
with the tests) and then declined. The depression scores of those
taking
curcumin also improved; the control group’s didn’t change. Brain
scans
revealed significantly less amyloid and tau accumulation in two brain
regions
of the participants taking curcumin — the amygdala and hypothalamus,
which
control anxiety, memory, decision-making, and emotion. Curcumin
Attenuates on
Carbon Tetrachloride-Induced Acute Liver Injury Molecules, February
2018
Curcumin pre-treatment significantly decreased CCl4-induced
inflammation.
Furthermore, curcumin pre-treatment significantly down-regulated the
expression
of TGF-β1 and Smad3 mRNAs (both p < 0.01), and up-regulated the
expression of
nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p
<
0.01) in the liver. Inhibition of HO-1 attenuated the protective effect
of
curcumin on CCl4-induced acute liver injury. Given these outcomes,
curcumin
could protect against CCl4-induced acute liver injury by inhibiting
oxidative
stress and inflammation, which may partly involve the activation of
Nrf2/HO-1
and inhibition of TGF-β1/Smad3 pathways. Curcumin ‘improves mood and
memory
Health Spectator, February
2018
Daily consumption of curcumin improves the memory and mood of people
with mild,
age-related memory loss, according to a new study by the University of
California, Los Angeles. The research, which has been published the
American
Journal of Geriatric Psychiatry, examined the effects of an easily
absorbed
curcumin supplement on memory performance in people without dementia,
as well
as curcumin’s impact on the microscopic plaques and tangles in the
brains of
people with Alzheimer’s. Found in turmeric, curcumin has previously
been
shown to have anti-inflammatory and antioxidant properties in lab
studies. It
also has been suggested as a possible reason that senior citizens in
India,
where curcumin is a dietary staple, have a lower prevalence of
Alzheimer’s
and better cognitive performance. The people who took curcumin
experienced
significant improvements in their memory and attention abilities, while
the
subjects who received placebo did not. In memory tests, the people
taking
curcumin improved by 28 per cent over the 18 months. Those taking
curcumin also
had mild improvements in mood, and their brain PET scans showed
significantly
less amyloid and tau signals in the amygdala and hypothalamus than
those who
took placebos. How turmeric can help treat irritable bowel syndrome
(IBS) The
Health Site, February
2018
The active ingredient in the spice, curcumin, has a laundry list of
health
benefits. A recent case study in the BMJ showed how a cancer-stricken
57-year-old woman who was given only a few months to live cured herself
with
turmeric. Currently, there is enough evidence to make a case for
turmeric as
complementary therapy also for irritable bowel syndrome or IBS. The
beneficial
effects of turmeric on IBS could be attributed to its
anti-inflammatory,
antioxidant, antibacterial and spasmolytic effects. Another
2010
study conducted on animals showed that curcumin in the turmeric could
be
beneficial in curbing stomach disorders such as diarrhoea, cramps and
IBS. How
a Nutritionist Uses Turmeric For Health Pop Sugar, February
2018
Research published in the journal Oncogene found that turmeric is
actually a
more effective anti-inflammatory than over-the-counter pain relievers
like
aspirin and ibuprofen. ADVERTISEMENT This is a modal window. The media
could
not be loaded, either because the server or network failed or because
the
format is not supported. Turmeric can also be used to increase levels
of
brain-derived neurotrophic factor (BDNF), which is a growth hormone in
the
brain that, when low, is responsible for increased risk of Alzheimer's
disease,
depression, and a host of other mental ailments. The curcumin in
turmeric has
also been proven to reverse symptoms of heart disease. Many other
studies have
found a parallel function and effect of the substance on your heart as
compared
to exercise. Health benefits of turmeric Philstar, February
2018
Antidepressants. Curcumin the main substance in turmeric may be used as
an
effective and safe therapy for treatment in patients with mild
depression.
Arthritis management. Because curcumin is known for its powerful
anti-inflammatory and pain-reducing characteristics, it has an amazing
effects
on people suffering from various types of arthritis. Cancer treatment. A
number
of laboratory studies on cancer cells have shown that curcumin does
have
anticancer effects. It seems to be able to kill cancer cells and
prevent more
from growing. It has the best effects on breast cancer, bowel cancer,
stomach
cancer, and skin cancer cells. Diabetes management. For lowering blood
sugar
and reversing insulin resistance, there’s arguably no better natural
treatment than adding turmeric into your diet. Obesity. A study
published in
the journal “Biofactors†showed that curcumin can help promote
weight loss.
The researchers found that the anti- inflammatory properties in
curcumin were
effective at suppressing the inflammatory process of obesity, therefore
helping
to reduce obesity and its “adverse health effects.†Cholesterol
regulators.
One of the reasons heart disease is such a problem in the U.S. is that
people
are developing pre-diabetes (high blood sugar) at an alarming rate. A
study
done by “Drugs in R & D found that curcumin was equal, or more
effective than
diabetes medication at reducing oxidative stress and inflammation in
the
treatment of high cholesterol. Painkillers. One of the more widely
accepted
properties of curcumin in scientific communities is its ability to
manage pain.
Therapeutic use of turmeric and other curcumin-rich plants are
displacing
conventional medical treatments and proving it’s a legitimate natural
pain
killer. Regulation of Polyamine Metabolism by Curcumin for Cancer
Prevention
and Therapy Medical Sciences, February
2018
Curcumin (diferuloylmethane), the natural polyphenol responsible for
the
characteristic yellow pigment of the spice turmeric (Curcuma longa), is
traditionally known for its antioxidant, anti-inflammatory, and
anticarcinogenic properties. Capable of affecting the initiation,
promotion,
and progression of carcinogenesis through multiple mechanisms, curcumin
has
potential utility for both chemoprevention and chemotherapy. In human
cancer
cell lines, curcumin has been shown to decrease ornithine decarboxylase
(ODC)
activity, a rate-limiting enzyme in polyamine biosynthesis that is
frequently
upregulated in cancer and other rapidly proliferating tissues. Numerous
studies
have demonstrated that pretreatment with curcumin can abrogate
carcinogen-induced ODC activity and tumor development in rodent
tumorigenesis
models targeting various organs. This review summarizes the results of
curcumin
exposure with regard to the modulation of polyamine metabolism and
discusses
the potential utility of this natural compound in conjunction with the
exploitation of dysregulated polyamine metabolism in chemopreventive
and
chemotherapeutic settings. Supplements That Enhance Detoxification
Newsmax,
February
2018
Curcumin, quercetin, hesperidin, ellagic acid, naringenin and other
flavonoids
enhance phase II detoxification. They also protect liver cells and
other
tissues and organs. They are all powerful antioxidants and more
versatile than
the antioxidant vitamins. Antitumor activity of curcumin by modulation
of
apoptosis and autophagy in human lung cancer Oncology Reports, February
2018
Curcumin is known to exhibit anticancer effects on various cancers with
selective cytotoxicity in tumor cells. Our results showed that curcumin
inhibited the viability of A549 cells time‑ and dose‑dependently.
In
addition, a dosage-dependent A549 cell apoptosis‑induction phenomena
was
observed by the curcumin intervention. Moreover, obvious autophagy was
induced
after curcumin‑treatment, characterized by the formation of
fluorescent
particles [autophagic vesicles (AVs)] and significant increase in ratio
of
LC3‑Ⅱ/LC3â€‘â… and Beclin1 as well as decreased p62
expression.
Furthermore, the effect of curcumin on a substantial downregulation of
phosphatidylinositol 3‑kinase (PI3K)/Akt/mammalian target of
rapamycin (mTOR)
pathway was observed. It is worth noting that the inhibition of mTOR by
rapamycin or of PI3K/Akt by LY294002 augmented curcumin‑induced
apoptosis and
autophagy, leading to significant inhibition of cell proliferation.
From these
findings, it can be speculated that curcumin potently inhibit the cell
growth
of NSCLC A549 cells through inducing both apoptosis and autophagy by
inhibition
of the PI3K/Akt/mTOR pathway. These results support the potential use
of
curcumin as a novel candidate in treatment of human lung cancer.
Diabetes and
Obesity Linked to Higher Cancer Risk: 4 Foods That Reduce This Risk
NDTV,
February
2018
Turmeric: The principle component of turmeric is curcumin which is a
potent
antioxidant scavenging free radicals and inhibiting the growth of
cancerous
cells. Almost 2000 published scientific papers have shown that curcumin
has the
ability to kill cancer cells while not harming the healthy cells.
Curcumin
Protects against Atherosclerosis Journal of Agricultural and Food
Chemistry,
February
2018
Curcumin supplementation significantly reduced TLR4 expression and
macrophage
infiltration in atherosclerotic plaques. Curcumin also reduced aortic
interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), vascular
cell
adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1
(ICAM-1)
expression, nuclear factor-κB (NF-κB) activity, and plasma IL-1β,
TNF-α,
soluble VCAM-1 and ICAM-1 levels. In addition, aortic sinus sections
revealed
that curcumin treatment reduced the extent of atherosclerotic lesions
and
inhibited atherosclerosis development. In vitro, curcumin inhibited
NF-κB
activation in macrophages and reduced TLR4 expression induced by
lipopolysaccharide. Our results indicate that curcumin protects against
atherosclerosis at least partially by inhibiting TLR4 expression and
its
related inflammatory reaction Turmeric pills help woman survive blood
cancer
Los Angeles Times, January
2018
In
2011
, Ferguson decided to take daily supplements of curcumin, the
beneficial
compound in turmeric, every night. A couple of months after she began
the
regimen, she started on a weekly course of hyperbaric oxygen therapy.
The
non-traditional treatment involves breathing in pure oxygen from an
enclosed
chamber with specific atmospheric pressure adjustments. Since then,
Ferguson's
cancer has remained stable and her blood counts are within a safe and
normal
range. Of course, due to the close proximity of her introduction of
turmeric
and the hyperbaric oxygen therapy, it's uncertain whether it was the
turmeric
that cured the progression of her disease. "The fact that our patient,
who had
advanced stage disease and was effectively salvaged while exclusively
on
curcumin, suggests a potential antimyeloma effect," the report
concludes. "We
would recommend further evaluation of curcumin in myeloma patients in
the
context of a clinical trial." British Woman Beats Rare Cancer With 2
Teaspoons
Of This Per Day The Alternative Daily, January
2018
Ferguson decided to try treating herself with a “golden spiceâ€
called
curcumin, which is a naturally occurring chemical compound in the herb
turmeric
after she had heard about how another woman (named Margaret) had used
it
successfully to treat her myeloma. Ferguson began taking eight grams
(about two
teaspoons) of curcumin per day for about five years. As a result, she
is now
vastly improved to the point where her cancer count is considered both
manageable and negligible. Jamie Cavenagh, professor of blood diseases
at
London’s Barts Hospital, who has subsequently co-authored a report on
Ferguson’s case, believes curcumin was a decisive part of her amazing
recovery. As Cavenagh explains, “When you review her chart, there’s
no
alternative explanation for her recovery other than we’re seeing a
response
to curcumin.†Dr. Abbas Zaidi, a hematologist at Barts NHS Health
Trust, who
contributed to the report on Ferguson, also believes that curcumin
played an
important role in her improvement. Curcumin attenuates collagen-induced
inflammatory response through the “gut-brain axis†Journal of
Neuroinflammation, January
2018
Oral administration of curcumin restored the imbalance between the
sympathetic
and parasympathetic tones in CIA rats and increased ChAT activity and
expression of ChAT and VAChT in the gut, brain, and synovium.
Additionally, VGX
eliminated the effects of curcumin on arthritis and ACh biosynthesis
and
transport. Electrophysiological data showed that curcumin markedly
increased
neuronal excitability of the vagus nerve. Furthermore, selective α7
nAChR
antagonists abolished the effects of curcumin on CIA. Our results
demonstrate
that curcumin attenuates CIA through the “gut-brain axis†by
modulating the
function of the cholinergic system. These findings provide a novel
approach for
mechanistic studies of anti-arthritic compounds with low oral
absorption and
bioavailability. Healing foods Navhindtimes.in January
2018
Curcumin is a powerful antioxidant with powerful anti-inflammatory
effects.
Studies have shown that curcumin and turmeric have antimutagenic and
anticancer
properties and have also been shown to be effective against
Alzheimer’s
disease in animal models. A glass of hot milk with a pinch of haldi is a
common
household remedy for a cold and sore throat. Curcumin is fat soluble
and needs
to be absorbed in the presence of fat. Hence haldi should be fried
along with
the seasonings in oil. Black pepper has also been found to increase the
absorption of cucurmin. Supplements containing haldi extracts or
curcumin
should be taken after a meal as the fat in the meal helps in its
absorption.
The miracle of turmeric: How can this golden spice help reinvigorate
your
health Express, January
2018
The 67-year-old, who had battled blood cancer for five years, began
taking
daily doses of curcumin, one of the main compounds of turmeric. More
familiar
as an ingredient in curries the spice is also an ancient remedy for a
variety
of ailments. While this natural approach won’t work for everyone the
Londoner’s cancer-cell count is now negligible. As Dieneke’s
doctors hail
the remarkable results we take a look at turmeric and the ways in which
it may
boost health. The spice, recognisable by its golden colour, is ground
from the
dried root of a plant called Curcuma longa. A relative of ginger it
thrives in
warm, moist conditions and has long been used as a medicine in Chinese
and
Indian cultures. Turmeric’s healing powers are attributed to
phytochemicals,
compounds which are present in many plants. Curcumin, which is found in
turmeric, is claimed to be one of the most powerful remedies in
nature’s
medicine cabinet. Another benefit of turmeric may be combating
depression,
stress and anxiety. It is claimed curcumin can be used as a natural
alternative
to drugs such as Prozac, working by inhibiting an enzyme in the brain
that is
responsible for depression. There may be a double whammy as it is
claimed
curcumin can also increase levels of serotonin and dopamine –
chemicals that
boost happiness. The powers of curcumin could even extend to improving
the sex
life of men by improving blood flow to the genitals. Wonder curry spice
could
be used to treat cancer after stunning doctors Leicester Mercury,
January
2018
Ms Ferguson began taking 8 grams of curcumin - one of the main
compounds in
turmeric - each day in tablet form. It’s the equivalent of about two
teaspoons. Her illness has an average survival of just over five years -
making
it one of the most fatal forms of the disease. It was rapidly spreading
-
causing increasing back pain - and she had already had a second
relapse. Dr
Abbas Zaidi, a haematologist at Barts NHS Health Trust, said: "Here we
describe
a myeloma patient who started a daily dietary supplement of curcumin
when
approaching her third relapse. "In the absence of further antimyeloma
treatment
the patient plateaued and has remained stable for the last five years
with good
quality of life." The remarkable improvement described in BMJ Case
Reports
follows previous research into the health benefits of turmeric which is
packed
with antioxidants. Cancer patient, 67, ‘beats the disease with the
help of
TURMERIC’ after five years of chemo failed The Sun, January
2018
In
2011
she began taking daily doses of curcumin, a key component of the spice
turmeric, after another two rounds of stem cell therapy failed. Dieneke
took
eight grams of curcumin each night on an empty stomach. Dieneke took
eight
grams of turmeric every night and her blood cancer stabilised. Over the
last
five years her cancer has remained stable and her blood counts are
within the
normal range, doctors report. She has also maintained a good quality of
life
during this period, according to the report. Curcumin is a
micronutrient
derived from the herb turmeric, and has been used as a traditional
Indian
medicine for centuries. Foods That Can Help You Prevent from Getting
Cancer
Your Health Mag, January
2018
Curcumin, a major component of curry, contains curcumin, which blocks
or
reduces tumors. Woman Halts Cancer in Its Tracks With Turmeric Metro,
January
2018
She took 8g of turmeric tablets every day for years without further
treatment,
and has now shocked doctors. ‘To the best of our knowledge, this is
the first
report in which curcumin has demonstrated an objective response in
progressive
disease in the absence of conventional treatment,’ her doctors, from
Barts
Health NHS Trust in London, wrote in the British Medical Journal Case
Reports.
‘In the absence of further antimyeloma treatment the patient
plateaued and
has remained stable for the past five years with good quality of
life.’
Turmeric is widely used in Asian cuisine and helps create distinctive
colour in
curries – but it would be impossible to cure myeloma with regular
cooking
turmeric. It would be impossible to treat cancer with regular kitchen
turmeric,
as it contains just 2% curcumin. What is curcumin? Brit woman claims
the wonder
spice halted incurable blood cancer for a decade International Business
Times,
January
2018
Dieneke Ferguson said she takes 8gram curcumin every day in a tablet
form to
fight the incurable myeloma. After all other treatments failed, North
London
resident Ferguson decided to fight back and began using curcumin — a
component derived from a popular Indian spice turmeric. She said she
has been
taking 8gram of the compound every day in a tablet form and the result
has been
nothing less than a miracle. "I have been on all sorts of toxic drugs
and the
side-effects were terrifying. At one point I lost my memory for three
days, and
in
2008
two of the vertebrae in my spine collapsed so I couldn't walk," the
cancer
survivor said, as quoted by the Daily Mail. "They injected some kind of
concrete into my spine to keep it stable." Her recovery has since
baffled
doctors who are yet to come to a conclusion on the effectiveness of
curcumin.
"Here we describe a myeloma patient who started a daily dietary
supplement of
curcumin when approaching her third relapse. In the absence of further
antimyeloma treatment the patient plateaued and has remained stable for
the
last five years with good quality of life," Dr Abbas Zaidi, a
haematologist at
Barts NHS Health Trust said in a report, which mentions that her cancer
cell
count is currently negligible."Curcumin is a polyphenol derived from
the
perennial herb turmeric and has - for centuries - been used as a
traditional
Indian medicine," explains Zaidi in the case study. "The biological
activity of
curcumin is indeed remarkable." He added that the pigment produces
multiple
effects through its "natural antioxidant, anti-inflammatory, antiseptic
and
analgesic properties" Curcumin targets gut-brain axis in reducing
inflammation,
study finds Horsetalk, January
2018
The research team from the China Pharmaceutical University in Nanjing
said many
studies in recent years had shown that taking curcumin by mouth eased
collagen-induced arthritis. A clinical trial, they noted, had shown
that
curcumin was safe and effective for patients with rheumatoid arthritis.
However, studies had shown that its bioavailability was poor, which
raised
questions about how it produced its anti-inflammatory effect. They set
out to
explore whether the gut-brain axis was involved in its therapeutic
action. The
researchers found that curcumin did indeed reduce collagen-induced
arthritis
through the gut-brain axis by regulating the function of the
cholinergic system
Chemopreventive and Antitumor Efficacy of Curcumin in a Spontaneously
Developing Hen Ovarian Cancer Model Cancer Prevention Research,
December
2017
Our results demonstrated for the first time that daily curcumin intake
leads to
a significant and dose-dependent reduction in spontaneous ovarian
cancer
incidence and tumor growth, indicating a tremendous role for curcumin
as a
chemopreventive strategy for ovarian cancer. The Effect Of Curcumin On
Plasma
Metabolomic Profile In Atherogenic Diet Induced Rat Model Of
Alzheimer’s
Disease Nutrition and Food Science, December
2017
Curcumin, a polyphenol extricated from the plant Curcuma longa, has
demonstrated its remedial advantages in Alzheimer's ailment and was
utilized as
a positive control. Curcumin exhibited a potential therapeutic effect
in high
cholesterol diet induced AD. Curcumin reverses tobacco smoke‑induced
epithelial‑mesenchymal transition Molecular Medicine Reports,
December
2017
Tobacco smoke is a major risk factor for lung cancer.
Epithelial‑mesenchymal
transition (EMT) is decisive in cancer invasion and metastasis, and
therefore
promotes cancer progression. The chemopreventive effect of curcumin on
carcinogenesis has been reported in vivo and in vitro. Curcumin
treatment
inhibited tobacco smoke‑induced MAPK/AP‑1 activation, including
ERK1/2, JNK
and p38 MAPK pathways, and AP‑1 proteins, and reversed EMT
alterations in
lung tissue. The results of the present study provide new insights into
the
molecular mechanisms of tobacco smoke‑associated lung cancer and may
open up
new avenues in the search for potential therapeutic targets in lung
tumorigenesis. Potent Remedies That Support the Liver Care 2, December
2017
Turmeric is a potent spice with many health benefits. Recent studies
show it
can improve circulation, prevent cancer, reduce pain and detoxify the
body.
Thanks to curcumin, a bioactive compound found in turmeric, this herb
helps the
liver remove toxins and wastes from the body. It’s also worth
mentioning that
curcumin increases production of bile, and as a result improves liver
function.
Exactly How Much Turmeric to Have a Day to Reap Its Anti-Inflammatory
Benefits
Pop Sugar, December
2017
"Turmeric is recommended for many patients with inflammatory conditions
such as
Crohn's disease, ulcerative colitis, autoimmune conditions like
psoriasis,
rheumatoid arthritis, osteoarthritis, Parkinson's disease, Alzheimer's
disease,
dementia, and cancers. Curcumin is the compound found in turmeric,"
said
Atlanta-based integrative medicine physician Dr. Bindiya Gandhi.
Arguably, the
most powerful aspect of curcumin is its ability to control
inflammation. "The
journal Oncogene published the results of a study that evaluated
several
anti-inflammatory compounds and found that aspirin and ibuprofen are
least
effective, while curcumin is among the most effective anti-inflammatory
compounds in the world," said Dr. Josh Axe, DNM, CNS, DC, bestselling
author of
Eat Dirt. "This news should have reached every household in the world
after the
study was conducted, because inflammation puts people at risk for
almost every
disease process known to man," he said. You can find turmeric in powder
culinary spice form and in its whole root form, as well as in tincture,
tablets, and capsules. "A good starting dose for its anti-inflammatory
benefits
is 400 to 600 mg of standardised powder or curcumin turmeric extract
three
times a day as tolerated," Dr. Gandhi said. Curcumin: common dietary
supplement
turned anti-cancer compound? Oxford University Press, December
2017
Over the past few decades, curcumin, a common food additive, has been
identified as a potential anti-inflmmatory and anti-cancer compound.
Curcumin
is a phenolic compound extracted from the Curcuma longa plant, and was
traditionally used as a spice for improving flavor and color into
dishes of
various Asian countries. Curcumin’s health benefits are not a new or
surprising finding — the brightly colored compound has been used in
Ayurvedic
medicine for centuries for its potent anti-inflammatory and anti-tumor
properties — but the fundamental mechanisms underlying its
anti-cancer
potential still remain an active area of interrogation. Intriguingly,
curcumin
has been shown to sensitize multiple cancers to chemotherapy drugs, and
several
recent studies have reported that curcumin is able to specifically
target
cancer stem cells. . As suggested by other groups, not only did we
demonstrate
that curcumin was able to enhance the sensitivity of gemcitabine in
these
resistant cells, we found that curcumin was also able to inhibit the
growth of
cancer stem cells. In our study, we also discovered that curcumin was
regulating a class of non-coding RNA called “long non-coding RNAsâ€
(lncRNAs). LncRNA is a relatively newly discovered type of non-coding
RNA —
RNA which does not make protein — found to be dysregulated in most
cancers.
We discovered that curcumin inhibits the expression of one of the most
well-known lncRNA-based oncogenes, a gene that drives cancer, called
PVT1. This
lncRNA drives tumor progression through the regulation of another
well-recognized oncogene, called EZH2. EZH2 is one of the oncogenes
known to be
involved in drug resistance and is identified to be a potential
drug-able
target. Though the generation of specific EZH2 inhibitors remains
challenging,
the findings from our study indicate that curcumin could be used to
inhibit the
expression of EZH2, as well as the non-coding RNA that regulates EZH2.
Considering that curcumin is a commonly available health supplement, it
presents itself as a non-toxic compound and incredibly cost-effective
compound
for the potential treatment of cancer patients. Curcumin improves
diabetes
mellitus‑associated cerebral infarction by increasing the expression
of GLUT1
and GLUT3 Molecular Medicine Reports, December
2017
Curcumin is characterized by anti‑inflammatory, anti‑oxidative,
antiviral,
antifibrotic, anticoagulation and glucose regulatory functions.
Curcumin
markedly decreased cell apoptosis, indicating an anti‑apoptotic role
of
curcumin in the brain. To further evaluate whether curcumin prevented
cell
apoptosis by modulating the expression of GLUT1 and GLUT3, small
interfering
RNAs targeting GLUT1 and GLUT3 were selected. It was found that the
knockdown
of GLUT1 and GLUT3 inhibited the abundance of GLUT1, GLUT3 and B‑cell
lymphoma 2, even following incubation with curcumin. These data showed
that
curcumin protected brain cells from apoptosis and cerebral infarction,
predominantly by upregulating GLUT1 and GLUT3. Natural Remedies for
Tendonitis
Care 2, December
2017
An extract of the spice turmeric, which is often used in curries to
give them a
yellowish color, curcumin is an excellent choice in dealing with any
type of
inflammation. While there are few studies on its use for tendonitis,
preliminary research published in the Journal of Biological Chemistry
showed
that curcumin has a place in the healing of tendonitis. Curcumin
Enhances the
Efficacy of 5-FU in Colo205 Cell Lines Proceedings, December
2017
Curcumin was observed to increase the efficacy of 5-FU and accelerate
the
cytotoxic effect by removing the cytostatic period seen in the first 6
h. The
study results show that the combination of 5-FU and curcumin in Colo205
can
reduce the dose by increasing the cytotoxic activity of 5-FU and
reducing the
resistance to the anticancer drug. Health benefits of the humble
turmeric
Hindustan Times, December
2017
Turmeric is a root that is as popular as ginger in Ayurveda. Many of
its
beneficial aspects are due to its active compound, curcumin. Curcumin
has a
profoundly anti-inflammatory effect on the body, and provides a good
defence
system against diseases. Inflammation is the body’s reaction to toxic
elements in our environment, such as water with heavy chlorine, air
pollution,
unhealthy oil (trans fats), stress, lack of sleep, and overuse of
chemical
aromas, deodorants, cleaning agents, etc. Can Curcumin be Employed to
Promote
the Integration of Oncology and Natural Products? Proceedings, December
2017
Curcumin inhibits NF-kB activation pathway at a step before inhibitor
kappa B
alfa (IKBα) phosphorylation. Preclinical in vivo and in vitro trials
that
combine curcumin with tyrosine kinase inhibitors (TKIs) have shown that
this
combination shows better results than each treatment alone.
Retrospectively
evaluated seventeen NF-kB overexpressed cancer patients were treated
with i.v.
and oral bioavailable formulation of curcumin and appropriate TKIs.
TKIs
decision was made according to genetic profiling (FoundationOne®).
Toxicities
and response was evaluated according to RECIST and common toxicities
criteria.
All patients are stage IV and heavily pretreated. Our longest
experience comes
from adenoid cystic carcinoma and he has treated for 72 months by oral
curcumin
and 8 months by i.v curcumin. Disease control rate was 89.3% (15/17)
and no any
grade III-IV toxicities was observed related to curcumin. Curcumin is
multitargeted molecule with pleotrophic nature. Curcumin inhibits
NF-κB and
related proteins which promotes effectiveness of TKIs. And might be
considered
as long as we have to use chemotherapy, radiotherapy and TKI. Which
spice wins
for its medicinal properties? Daily Sabah Health, December
2017
What makes turmeric, which is quite rich in iron and manganese, a key
ingredient in alternative medicine is its active ingredient curcumin.
Curcumin
is one of the best herbs for good health due to large amounts of
vitamins C and
E. Turmeric is a lightened version of curcumin that can be used in
kitchens.
Thanks to the curcumin in it, turmeric regulates sleep patterns. It
also
prevents muscles from getting tired very quickly and boosts sports
performance.
Some studies indicate that by using turmeric, symptoms can be decreased
and
inflammation-related conditions, including arthritis, can be eased.
Moreover,
scientists have proven that consuming turmeric helps to slow down the
symptoms
of Alzheimer's disease. However, the signature benefit of turmeric is
in the
treatment of inflammation. Curcumin, quercetin and atorvastatin
protected
against the hepatic fibrosis by activating AMP-activated protein kinase
Journal
of Functional Foods, December
2017
Curcumin, quercetin, and atorvastatin protected against the hepatic
fibrosis by
reducing hepatic fat accumulation via AMPK up-regulation. Curcumin
Beats
Diabetes Drug at Lowering Blood Sugar: Study News Max, December
2017
“Natural remedies, however, can be very effective,†he adds. “A
large
number of studies have shown that curcumin can be very helpful at
decreasing
blood sugar as well as the complications of diabetes.†Other studies
have
shown its effectiveness in treating other aspects of diabetes, both in
Type 1
and Type 2 according to the Website, Diabetes Self Management. David
Spero,
R.N., says that research conducted by Beijing University of Chinese
Medicine
and McGill University showed that curcumin reduced both blood sugar and
cholesterol levels. Curcumin suppressed the activities of white blood
cells
called macrophages that cause inflammation as well as slowed down many
of the
complications of diabetes, in which inflammation plays a role. Curcumin
improved insulin function by helping the hormone get into the cells
thus
reducing insulin resistance. In a study of 240 people in Thailand,
curcumin
prevented prediabetes from developing into full blown diabetes. Roughly
16
percent of the people studied in the placebo group progressed to Type 2
diabetes within 9 months while nobody in the group receiving 250
milligrams of
curcuminoids from supplements progressed. Curcumin protects beta cells,
which
produce insulin. Studies have found that beta cells grew faster and
lived
longer in rats who consumed curcumin. In addition to its
diabetes-fighting
properties turmeric has been found to be an effective anti-inflammatory
—
even more effective than aspirin or ibuprofen and even Celebrex without
the
potentially deadly side effects of these drugs. As a cancer treatment,
multiple
studies have shown that curcumin holds promise in fighting against skin
cancer,
breast cancer, bowel and stomach cancers. A
2007
study found that curcumin combined with chemotherapy killed more cancer
cells
than chemotherapy alone. The American Cancer Society states that
curcumin
interferes with the development, growth, and spread of cancer cells.
Curcumin
has also been shown in multiple studies to be more effective than the
popular
drug Zoloft to beat depression,†adds Teitelbaum. “And if that’s
not
enough, current research suggests it may also decrease the risk of
developing
Alzheimer’s disease. The only side effect reported to my knowledge is
that
you start feeling fantastic.†Studies that prove Curcumin can kill at
least 3
types of cancer emaxhealth, November
2017
Lung cancer: The effects of curcumin in chronic obstructive pulmonary
disease
(COPD) airway inflammation and lung cancer progression, were tested in
an
animal model study. Scientists administered to mice, the natural
anti-inflammatory agent curcumin, 1% in diet before and during weekly
non-typeable Hemophilus influenzae (NTHi ) exposure, which has been
associated
with the pathology of COPD. It was observed that curcumin significantly
reduced
the number of visible lung tumors in the absence of NTHi exposure by
85% and in
the presence of NTHi exposures by 53%. It is important to note that
Nuclear
factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and
preneoplastic lesions, and the effect of curcumin in decreasing the
migratory
and invasive ability of A549 ( lung carcinoma cells) cells by
inhibiting
adiponectin expression is probably mediated through NF-κB/MMP
pathways.
Ovarian carcinoma: In vitro and in vivo experiments of curcumin with
and
without docetaxel (chemotherapy medication) were done using human
ovarian
cancer cell lines. It was observed that Curcumin inhibited inducible
NF-kappaB
activation and suppressed proliferation in vitro. In vivo dose-finding
experiments revealed that 500 mg/kg orally was the optimal dose needed
to
suppress NF-kappaB and signal transducers and activators of
transcription 3
activation and decrease angiogenic cytokine expression. Colorectal
cancer::Cyclo-oxygenase 2 (COX2), which mediates prostaglandin
synthesis during
inflammation, and which is selectively overexpressed in colon tumours,
is
thought to play an important role in colon carcinogenesis. But, a study
that
tested Human colon epithelial cells (HCEC) and SW480 colon carcinoma
against
curcumin, concluded that curcumin inhibits COX2 induction by the colon
tumour
promoters, tumour necrosis factor alpha or fecapentaene-12, which are
fecal
mutagens that are naturally produced in the human colon and have a role
in
neoplastic transformation of the colon. It is important to note that
curcumin,
not only affects signaling of proteins like tumor necrosis factor-(TNF)
or the
nuclear factor NF-κB. Curcumin also blocks interleukin-1 (IL-1)
signalling,
which as previously mentioned has been associated with the pathology of
different types cancer. Therefore, the powerful ability to interfere in
the
mechanisms involved in cancer, make curcumin a natural cancer killer.
Drastically Reduce Your Colon Cancer Risk Care2.com, November
2017
Curcumin, one of the phytonutrients found in the spice turmeric, has
been found
in numerous studies to reduce colon cancer risk. A study found in
Cancer
Prevention Research showed that curcumin suppresses the ability of
colon cancer
cells to proliferate, suggesting it is helpful both in the prevention
and
treatment of the condition. Curcumin Exerts Effects on the
Pathophysiology of
Alzheimer's Disease Frontiers in Neurology, November
2017
Curcumin, a major polyphenol from curry spice (Curcuma longa), has been
reported to inhibit Aβ aggregation, Aβ-induced inflammation, and the
activities of β-secretase and acetylcholinesterase in in vitro studies
(12,
13). Moreover, in in vivo studies, oral administration of curcumin has
resulted
in the inhibition of Aβ oligomerization, Aβ deposition, and tau
phosphorylation in the brains of AD animal models, as well as led to
the
improvements in behavioral impairment in animal models (12). In our
previous
study, we found that chronic curcumin administration ameliorates
Aβ1-42
induced AD-related cognitive deficits (13). However, more information
underlying the mechanism should be explored. Based on these research
results,
we speculated that curcumin may ameliorate AD pathogenesis by
regulating
PI(3,5)P2 and TRPML1 expression levels. To validate it, we first detect
the
effects of curcumin on lysosomes and the cell viability of hippocampal
HT-22
cells that treated with Aβ1-42. Sequencing technique was then used and
TRPML1
was identified as the most upregulated gene that affected by curcumin.
Afterward, the effects of curcumin on the autophagy-related proteins
were also
analyzed in vitro. Besides, we also determined that curcumin
ameliorated
autophagy–lysosome dysfunction by regulating PI(3,5)P2 and TRPML1 in
vivo.
Our study suggests that curcumin might be one of the most promising
compounds
for the interference of AD therapies. Turmeric is the spice of the year
Lifestyle.ynaija.com, November
2017
Turmeric's major component is curcumin, a powerful, medicinal substance
that
has anti-inflammatory properties, helps fight cancer and diabetes, aids
digestion, combats heart diseases, works as an anti-oxidant, works
magic on the
skin, reduces bloating, calms severe menstrual pain and essentially,
solves
more than a handful of life’s problems. Turmeric tea has potential to
ease
health conditions such as Alzheimers, athritis, obesity and chest pain.
Its
anti-inflammatory properties help boost the immune system and protect
the
brain. Its principal component, curcumin also contains anticancer
properties
and has been found useful in the treatment of brain, bone and breast
cancer.
The anti-inflammatory activity of curcumin Journal of Biological
Chemistry,
November
2017
The spice turmeric, with its active polyphenol curcumin, has been used
as
anti-inflammatory remedy in traditional Asian medicine for centuries.
Many
cellular targets of curcumin have been identified, but how such a wide
range of
targets can be affected by a single compound is unclear. We conclude
that the
paradigm of metabolic bioactivation uncovered here should be considered
for the
evaluation and design of clinical trials of curcumin and other
polyphenols of
medicinal interest. Turmeric may reduce inflammation from
osteoarthritis Daily
Herald, November
2017
Over the past two decades there have been many medical studies
evaluating the
effect of turmeric extracts including curcumin and reducing the pain
and
inflammation associated with osteoarthritis. The overall results of
these
studies strongly indicate that curcumin and other extracts of turmeric
reduce
inflammation as well as pain levels in patients with osteoarthritis. A
recent
study published in the Journal of Medicinal Food demonstrated that
extracts of
turmeric have a significant impact on the inflammation and pain
associated with
osteoarthritis. The study was a meta-analysis, which means that it
combined the
data from many smaller studies and the final result indicated that an
ancient
spice is very effective at reducing the inflammation and associated
symptoms of
osteoarthritis. This meta-analysis included middle-aged and elderly
people who
have symptoms of osteoarthritis in five or more joints. All of the
studies
demonstrated a significant reduction in pain and stiffness. They also
concluded
that approximately 1000 mg of curcumin a day gave a reduction in
symptoms
equivalent to over-the-counter analgesics. This is important because
turmeric
extracts and curcumin do not have the same gastrointestinal and
heart-related
side effects (bleeding, high blood pressure and increased risk of heart
attack)
associated with commonly used pain medications. The side effects seem
to be
increased in the elderly -- the very people most affected by
osteoarthritis.
Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in
Kidney,
Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor
Proceedings,
November
2017
Cancer is the second most common cause of death in the world. Several
natural
products have been studied for anticancer activity and for prevention
or repair
of oxidative injury. Curcumin is one of the natural products of high
medicinal
interest. This study showed that curcumin suppresses tumor progression,
and
alleviates the lipid peroxidation and improves antioxidant status in
the
tissues of solid tumor-bearing mice. Turmeric's Anti-Inflammatory
Properties
Science Trends, November
2017
It has been suggested that the compound curcumin helps the immune
system
destroy amyloid plaque, reducing the production of inflammatory
cytokines. In
doing so, brain function deterioration is reduced, slowing down the
development
of Alzheimer's disease. Epidemiological studies have looked at the
neuroprotective effect of curcumin and have demonstrated that regular
consumption has reduced other cognitive deficits in the elderly. Over
the years
curcumin has been a main focus for research regarding its strong
anti-tumor
effects. In fact, several preclinical trials have demonstrated curcumin
to have
both chemopreventive and anti-tumor effects against certain types of
cancer.
This naturally occurring polyphenolic compound recently has shown
promise as a
dietary therapy for pancreatic cancer. Of course, it shouldn't be
thought of as
a primary means for treating cancer, but it may reduce tumor promotion
and
minimize the spread of cancer. Turmeric has anti-inflammatory abilities
containing more than two dozen compounds which may help relieve
osteoarthritis
pain. Again, it’s the compound curcumin that works as an
anti-inflammatory
agent. Clinical studies have found that curcumin provided protection to
joint
inflammation in individuals with osteoarthritis. Ulcerative colitis is a
chronic, inflammatory bowel disease causing inflammation in the
digestive
tract. The disease tends to flare up and subside at random. Studies
have shown
people with ulcerative colitis who took curcumin had a significantly
lower
relapse rate than people who did not take curcumin. A meta-analysis
showed
curcumin had a high effect in reducing symptoms of depression, such as
irritable mood, reduced interest in pleasurable activities, fatigue or
feelings
of worthlessness. The analysis suggests that curcumin could possibly
have a
role in treating the symptoms of major depression. Curcumin suppresses
Notch‑1 signaling: Improvements in fatty liver and insulin resistance
in rats
Molecular Medicine Report, November
2017
Curcumin is a well‑known phenolic substance and has many
pharmacological
effects associated with metabolism. Curcumin administration led to a
downregulation in the expression of lipogenic genes, including sterol
regulatory element‑binding protein, fatty acid synthase and
acetyl‑CoA
carboxylase (P<0.05). The expression of inflammation‑associated
genes,
including nuclear factor‑κB, tumor necrosis factor‑α and
prostaglandin‑endoperoxide synthase 2 were also suppressed. The
results of
the present study suggest that the hepatic Notch‑1 pathway can be
suppressed
via curcumin treatment, which may ameliorate fatty liver and insulin
resistance
in rats subjected to a high fat diet. Foods for brain memory and
function The
Medium, November
2017
According to Uma Naidoo, turmeric is an ingredient found in curry that
appears
to be responsible for de-plaguing the brain. Naidoo also explains that
turmeric, also referred to as "Indian gold," has properties that
benefit the
brain, making you almost as bright as its own fiery complexion. The
ingredient
responsible for this powerful herb's effects on the brain is known as
curcumin.
Naidoo says, “Curcumin has been found to possess neuroprotective
properties,
and may help shield the brain against Alzheimer’s disease (AD) by
binding to
and eliminating toxic beta-amyloid plaques, which are a hallmark of
AD."
Anti-neuroinflammatory effect of curcumin International Journal of
Molecular
Medicine, November
2017
Curcumin is the main curcuminoid present in Curcuma longa and it has
been
previously reported to exhibit a wide range of pharmacological
activities.
Curcumin suppressed the secretion of inflammatory mediators through an
increase
in the expression of HO-1. Curcumin induced HO-1 transcription and
translation
through the Nrf2/antioxidant response element signaling pathway.
Inhibitory
experiments revealed that HO-1 was required for the anti-inflammatory
effects
of curcumin. Further mechanistic studies demonstrated that curcumin
inhibited
neuroinflammation by suppressing NF-κB and MAPK signaling pathways in
Pam3CSK4-activated microglial cells. The results of the present study
suggest
that curcumin may be a novel treatment for neuroinflammation-mediated
neurodegenerative disorders. Terrific Turmeric Steinbach Online,
November
2017
Due to recent research, curcumin has been nicknamed the "master
off-switch for
inflammation." It has been shown to help relieve pain and inflammation
by
modulating the inflammatory pathways that affect heart, joints, liver,
gastrointestinal tract, brain, cellular health and the immune system!
This
makes curcumin useful for relieving the pain in osteoarthritis,
rheumatoid
arthritis and bursitis as well as in digestive conditions such as
ulcerative
colitis, Crohn's disease, celiac disease, gastritis and gastric ulcers.
Curcumin has the ability to block more than 30 different inflammation
pathways!
Curcumin also protects against inflammatory calcium loss from our bones
and has
been shown to slow prostate cell proliferation in addition to
supporting
healthy cholesterol and blood pressure levels. Curcumin has
liver-protective
effects and is a powerful liver detoxifier. It helps to prevent the
build-up of
toxins, enhance glutathione levels, supports bile production and
solubility as
well as improve digestive function. Curcumin may help reverse certain
forms of
liver cirrhosis to some degree, and is thought to be especially helpful
for
people who regularly drink alcohol or use common painkillers, both of
which
damage cause liver damage. Studies suggest that curcumin can also
reduce the
severity of liver injury induced by iron overdose, cholestasis and
carbon
tetrachloride intoxication. In addition to supporting the liver
processes,
managing inflammation is also vital in aiding detoxification.
Inflammation
control is needed because the detoxification process involves the
release of
toxic metabolites from our cells and tissues in order to expel them
from the
body. On the way to being eliminated, these toxins can trigger
inflammatory
reactions and cause tissue damage. Curcumin, was originally researched
for
Alzheimer's disease because studies found there is a much lower
incidence and
prevalence of Alzheimer's in India than in North America. The
association
between curry consumption and cognitive level in certain populations
were
researched and it was found that those who ate curry foods performed
better on
a standard test than those who never or rarely ate curry! Alzheimer's
disease
degrades the nerve cells in the brain through inflammation in glial
cells, the
formation of beta-amyloid plaques, metal toxicity, and oxidative
damage.
Curcumin acts as a powerful anti-inflammatory and antioxidant in the
brain. It
can also break down plaques and has the potential to guard against
their
development, plus it supports healthy neurotransmitter function,
improving
memory and helping to prevent cognitive decline. Curcumin alleviates
liver
oxidative stress in type 1 diabetic rats Molecular Medicine Reports,
November
2017
The aim of the present study was to determine the effects of curcumin
on
antioxidants using a rat model of type 1 diabetes. The results provide
evidence
that oxidative stress in the STZ‑induced diabetic rat model may be
attenuated
by curcumin via the activation of the Keap1‑Nrf2‑ARE signaling
pathway, as
evidenced by a decrease in the blood glucose concentration and an
increase in
the transcription of several antioxidant genes. Natural ingredients to
help
manage aches and pains Body and Soul, November
2017
Turmeric is best known as a powdered spice used to give foods flavour
and
colour – think curries. It contains a natural chemical compound
called
curcumin that scientists have found to have anti-inflammatory and
antioxidant
properties. Research suggests turmeric and its components can
potentially
alleviate arthritis inflammation and pain. With curcumin accounting for
only
3-5% of turmeric, you’re unlikely to get enough from diet alone, so
consider
a supplement to help boost levels. Protective Effect of Curcumin
Against
Oxidative Stress-Induced Injury in Rats with Parkinson's Disease
Cellular
Physiology and Biochemistry, November
2017
Background/Aims: The study aimed to investigate the protective effect
of
curcumin against oxidative stress-induced injury of Parkinson’s
disease (PD)
through the Wnt/β-catenin signaling pathway in rats. This study
suggests that
curcumin could protect against oxidative stress-induced injury in PD
rats via
the Wnt/β-catenin signaling pathway. Keep breast cancer at bay
Telangana
Today, November
2017
The spice that gives curry its beautiful yellow colour contains a
chemical
called curcumin. The studies have shown that curcumin supplements could
play a
role in helping fight breast cancer tumours. Effect of Curcumin on the
Diversity of Gut Microbiota in Ovariectomized Rats Nutrients, November
2017
Curcumin has been proven to have a weight-loss effect in a menopausal
rat model
induced by ovariectomy. In conclusion, estrogen deficiency induced by
ovariectomy caused changes in the distribution and structure of
intestinal
microflora in rats, and curcumin could partially reverse changes in the
diversity of gut microbiota. Reduce Inflammation with an Ancient Wonder
Herb
Huffington Post, November
2017
Curmeric is a spice and a part of the ginger family that has been used
for
thousands of years. It's rich in a powerful natural phenol called
curcumin.
This wonder herb has been shown to be effective in treating low moods,
either
alone or in combination with an antidepressant. Curcumin contains
powerful
phytochemicals that reverse inflammation, and chronic inflammation has
been
shown to contribute to the development of a wide variety of disorders,
depression being one that may be closely linked. A
2014
randomized control study compared three groups of 20 participants each.
The
three groups were given curcumin alone, Prozac® + 1g of oil based
curcumin, or
Prozac alone for a six-week period. They then had their low moods
measured on a
common scale. Surprisingly, the group on curcumin alone did just as
well as
those on Prozac alone. While there was not a major statistical
significance
among any of the three groups, the group on the combination scored
best. The
researchers found no safety concerns with the daily curcumin usage and
concluded "This study provides first clinical evidence that curcumin
may be
used as an effective and safe modality for treatment in patients with
MDD
[major depressive disorder] without concurrent suicidal ideation or
other
psychotic disorders.†Curcumin modulates covalent histone
modification and
TIMP1 gene activation to protect against vascular injury in a
hypertension rat
model Experimental and Therapeutic Medicine, November
2017
Hypertension is a leading risk factor for morbidity and mortality.
Previous
studies have reported that curcumin has anti‑oxidation and
anti‑aging
effects and inhibits histone deacetylase activity. In conclusion,
curcumin
could relieve extracellular matrix degradation and interstitial
fibrosis
induced by hypertension, and lower blood pressure. It could also serve a
function in improving vascular structure through inhibiting the
expression of
HDAC1, thereby promoting TIMP1 transcription activation and suppressing
the
expression of MMP‑2 and TGFβ. Turmeric Is a Top Culinary Medicine
Natural
Products Insider, November
2017
Nutritionists, functional medicine GP's and physiotherapists commonly
use
curcumin for it's anti-inflammatory qualities. And it's no wonder
considering
six major scientific trials all found curcumin to possess a potent
anti-inflammatory action, which is completely non-toxic in nature. A
study
evaluating several pharmaceutical anti-inflammatory drugs, found that
aspirin
and ibuprofen are the least potent, while curcumin is among the most
potent
anti-inflammatory and anti-proliferative agents available.. Arthritis
is a
debilitating inflammatory disorder. Thankfully curcumin has been found
to help.
A recent study out of Japan evaluated its relationship with the
inflammatory
cytokine known to be involved in in the rheumatoid arthritis process.
Scientists discovered that curcumin "significantly reduced" these
inflammatory
markers. In fact its anti-inflammatory qualities are so strong a
2007
study compared curcumin and cortisone and found they were equal in
potency!
Most pharmaceutical anti-inflammatory drugs are contraindicated to use
over the
long-term, but turmeric is not only safe but beneficial for your
overall
well-being. Curcumin has been shown to equal in effectiveness to the
drug
metformin in the management of diabetes, but without negative side
effects. (5)
In the study curcumin was shown to lower blood glucose levels and
reverse
insulin resistance by suppressing glucose production in the liver.
Another
study found curcumin improved metabolic function and reduced the risk
of plaque
buildup in the arteries of type-2 diabetes patients. (6) Curcumin also
acts as
an anti-diabetic and antioxidant in patients with type-1 diabetes. With
anti
depressants prescriptions on an all time high, there has been a flood
or recent
trials attempting to get to the cause of depression. The core issue has
finally
been identified as inflammation. And curcumin has been found to be
comparable
to prescription antidepressant drugs.. In
2014
a randomized control trial took 60 volunteers diagnosed with major
depressive
disorder (MDD) and compared the effect of curcumin to fluoxetine
(Prozac). (9)
Researchers discovered that the principal curcuminoid in turmeric is
not only
as effective as Prozac in managing depression, but it doesn't carry
with it all
the dangerous side effects as anti-depressive drugs do. According to
the paper,
"This study provides first clinical evidence that curcumin may be used
as an
effective and safe modality for treatment in patients with MDD.â€
Efficacy and
safety of turmeric and curcumin in lowering blood lipid levels in
patients with
cardiovascular risk factors Nutrition Journal, November
2017
Turmeric and curcumin may protect patients at risk of CVD through
improving
serum lipid levels. Curcumin may be used as a well-tolerated dietary
adjunct to
conventional drugs. Curcumin Shrinks Aggressive Mesothelioma Tumors in
New
Study Surviving Mesothelioma, November
2017
The latest study of cucumin in malignant mesothelioma treatment was
conducted
by French scientists at several different research centers. The team
used cells
taken from rats that had been induced to develop one of the deadliest
and most
aggressive subtypes of asbestos cancer called sarcomatoid mesothelioma.
The
rats began to develop sarcomatoid mesothelioma tumors in their abdomens
within
weeks of being injected with asbestos. The French scientists tested
curcumin on
cells from these tumors to determine the ideal killing dose. The team
then used
the sarcomatoid mesothelioma rats to test the treatment in vivo, in
living
animals. Compared with an epigenetic drug called SAHA, curcumin
injected
directly into the peritoneal cavities of sick rats was more effective
and
started to destroy their tumors in less two weeks. "The treatment of
tumor-bearing rats with 1.5 mg/kg curcumin on days 7, 9, 11 and 14
after tumor
challenge dramatically reduced the mean total tumor mass at day 16,"
reports
Dr. Daniel L. Pouliquen, lead author on the report in Oncotarget.
Earlier this
year, scientists in the Department of Experimental Medicine at the
University
of Rome conducted a similar experiment and that found that
intraperitoneal
curcumin extended survival in mice with mesothelioma. In
2015
, mesothelioma researchers with Flinders University in Australia
determined
that curcumin had the ability to keep mesothelioma tumors from giving
rise to
their own new blood vessels. That study suggested that curcumin could
become a
supplemental treatment for certain mesothelioma patients. Curcumin is
able to
inhibit breast cancer cells Oncology Letters, October
2017
The present study investigated the inhibitory effect of curcumin on
human
breast cancer MCF‑7 cells and investigated the potential underlying
molecular
mechanisms. MCF‑7 cells were cultured with curcumin at different
concentrations and time points. The proliferation of MCF‑7 cells in
the group
treated with curcumin was markedly decreased compared with the control,
with
the greatest inhibitory effect at a concentration of 20 µM. The
expression of
Bax mRNA was increased and Bcl‑2 mRNA expression was decreased
compared with
the control. Additionally, protein expression of NF‑κB and IκB was
increased. The data indicate that curcumin is able to inhibit breast
cancer
cell proliferation, possibly by regulating the NF‑κB signaling
pathway. The
Remarkable Anti-Cancer Activities of Curcumin Experiment.com October
2017
Curcumin, a diferuloylmethane, is a phytochemical derived from the
rhizome of
Curcuma longa, a member of the ginger family. It has been used orally
and
safely as a spice and for medicinal purposes for many thousands of
years in
southern Asia and India. There are numerous published articles on
laboratory,
animal, and human studies examining its effect as an anti-proliferative
and
anti-inflammatory on a wide variety of diseases. It enhances induction
of tumor
antigen-specific, PD-1-positive,, Cytotoxic T Lymphocytes [the Death
Receptor]
(1,2);,, It arrests cancer, cells in various phases of the cell cycle,
and
induces apoptosis primarily through a, mitochondrial pathway
involving,,
caspase-8-dependent BID cleavage (3);,, It has been shown, to inhibit
constitutive NF-kB activation, induce G1/S arrest,,, suppress
proliferation,
and induce apoptosis in mantle cell lymphoma (4);,, It induces
apoptosis in
human melanoma cells through a Fas Receptor/Caspase-8 pathway,
independent of
p53 (5);,, It suppresses the proliferation of human vascular
endothelial
cells,, in vitro and inhibits the Fibroblast Growth Factor-2-induced
angiogenic,, response in-vivo (6);,, It induces apoptosis in the human
acute
myelogenous leukemia cell, line HL-60, believed to, occur through the
mitochondrial pathway involving caspase-8, BID cleavage,, cytochrome C
release,
and caspase-3 activation (7);,, It downregulates action of NF-kB and
the
antiapoptotic genes,, regulated by NF-kB,, a critical role in
inhibiting cancer
cell survival and proliferation in pancreatic cancer (8);,, It
suppresses
expression of NF-kB, Bcl-2 and Bcl-XL in multiple,, myeloma cell lines
(9);,,
It potentiates the antitumor activity of gemcitabine in an in-vivo,,
pancreatic
cancer model through, suppression of proliferation, angiogenesis, and
inhibition of NF-kB -regulated, gene products (10);,, It induces
gemcitabine
sensitivity in pancreatic cancer cells through modulation of miR-200
and
miR-21, expression (11);,, It inhibits tumor growth and angiogenesis in
an
orthotopic mouse model of,, human pancreatic cancer (12);,,, A
liposomal-encased, formulation of curcumin was studied in pancreatic
cancer
cell lines in vitro and in vivo, by, intravenous infusion, in athymic
mice at
the M.D. Anderson Cancer Center in, Houston, Texas. Liposomal Curcumin
was
shown to down-regulate the NF-kB, machinery, suppress tumor growth, and
induce
apoptosis in vitro, and demonstrated a reduction in, tumor burden and
angiogenesis in vivo (13);,, It inhibits growth and survival of human
head and
neck squamous carcinoma cells with modulation of of, NF-kB signalling
(14). A
Powerful And Cheap Supplement That You Aren't Using Enough MensXP.com
October
2017
The effects of curcumin are very similar to any synthetic
anti-inflammatory
drug. While synthetic drugs have side effects and may only be
prescribed when
needed, curcumin on the other hand, is a natural substance without side
effects. Inflammation is an essential physiological function. Without
our
body's inflammation mechanism we would have no protection against
pathogens.
Although, short term (acute) inflammation works in our favor, but
prolonged
(chronic) inflammation which is a result of modern day stressful
lifestyle is a
key contributor to many western diseases. This includes heart disease,
cancer,
metabolic syndrome, Alzheimer's and much other health detrimental
conditions.
Including curcumin in the diet ensures the prevention of chronic
inflammation.
This is one benefit that our grandmother knew well before science
confirmed it.
This is the reason why you got a glass of hot milk mixed with turmeric
every
time you got injured. Curcumin is proven to relieve pain significantly
at
higher doses of 400-500mg. The pain relief benefits were found in
post-operative patients and people suffering from arthritis and
osteoporosis.
This is comparable to 2g acetaminophen in potency. (a powerful
painkiller).
Turmeric is a potential aid against precancerous cells The Plaid Zebra,
October
2017
Curcumin is one of the most powerful non-pharmaceutical
anti-inflammatory
compounds out there. It may provide the greatest benefits for stomach,
breast,
skin, bowel, brain, ovarian, colon, and prostate cancers. In fact, The
American
Cancer Society says that turmeric can be a potential treatment. It
works by
protecting the body from free radicals. Studies have also shown that
curcumin
also interrupts the progression, spread, and growth of cancerous cells.
It also
helps with the inflammation that is associated with the progression of
cancer.
The American Cancer Society mentions a study in which curcumin kills
cancer
cells in isolation, as noted in laboratory dishes.,,Curcumin inhibits
COX-2,
the enzyme that leads to negative inflammation that eventually leads to
cancer.
It also takes away the oxygen that fuels cancer cells. Additionally, it
kills
large cell B-cell lymphoma cells, and prevents the rebirth of cancer
stem
cells. Turmeric and curcumin have anti-carcinogenic agents. Carcinogens
are
greatly impactful to the development of cancerous cells. It mediates
anti-carcinogenic action by raising levels of antioxidant enzymes.
Curcumin and
its derivatives are associated with anti-tumour activity. Curcumin and
Pancreatic Cancer Treatments HealthProfessionalRadio.com October
2017
Ajay Goel, PhD., is Director of Translational Genomics and Oncology,
and the
Director of the Center for Gastrointestinal Research at the Baylor
Scott &
White Research Institute, Baylor University Medical Center in Dallas,
TX. He is
currently researching the prevention of gastrointestinal cancers using
integrative and alternative approaches, including botanical products.
Two of
the primary botanicals he is investigating are curcumin (from turmeric)
and
boswellia. Dr. Goel is a member of the American Association for Cancer
Research
and the American Gastroenterology Association and is on the
international
editorial boards of World Journal of Gastroenterology and World Journal
of
Gastrointestinal Oncology. Segment overview: Dr. Ajay Goel, PhD, senior
author
on a recent study published in the Oxford University Press’ journal
“Carcinogenesis†that shows clinical relevance for combining
curcumin with
chemotherapy to overcome chemoresistance in pancreatic cancer patients.
Neuroprotective effects of curcumin Molecular Medicine Reports, October
2017
Curcumin is a natural product with antimutagenic, antitumor,
antioxidant and
neuroprotective properties. The results of the present study suggest
that
pretreatment with curcumin can prevent the development of LIDD in rats.
It was
revealed that treatment with curcumin significantly reduced interleukin
(IL)‑1β and IL‑6, iNOS, COX‑2 and MMP‑9 levels in rats with
LIDD. In
addition, treatment with curcumin reduced the mRNA expression levels of
TGF‑β1 and TGF‑β2, whereas it increased the mRNA expression
levels of
BDNF in rats with LIDD. In conclusion, the present findings indicate
that
curcumin may exert protective effects on LIDD development, exerting its
action
through the regulation of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF.
A
compound in turmeric could make cancer cells more sensitive to
radiation
Scroll, September
2017
Pre-treatment with curcumin – a safe herbal compound derived from
turmeric
– makes cancer stem cells sensitive to radiation therapy. It has
found that
combined effect of curcumin and exposure to radiation was markedly more
effective in lowering AP-1 levels thereby rendering cells unviable for
growth
and replication. When treated with radiation alone, there was delayed
but
increased rate of proliferation and tumor formation. The mechanism of
curcumin-induced inhibition lends credibility to AP-1 as a drug target
and
therapeutic utility of curcumin for radio-sensitisation of cervical
cancer stem
cells for better treatment outcomes. Natural ways to support a healthy
liver
News-Medical.net September
2017
Turmeric is a bright orange spice which has been long used in Indian
cuisine
and Ayurvedic medicine. Turmeric is reported to have the ability to
protect the
liver from damage. Animal studies have shown that mice fed curcumin,
one of the
active ingredients in Turmeric, suffered less liver damage over time
compared
with those on a normal diet. Curcumin has even been found to have a
beneficial
effect in the treatment of liver disorders. Investigating the effect an
over-the-counter anti-inflammatory supplement called Curcumin has on
the onset
of Alzheimer’s. AustralianAgeingAgenda.com September
2017
The preliminary findings suggested a longer period of time taking the
supplement was required and the study has been extended for two years,
Dr
Goozee said. “We believe having people on the long-term Curcumin may
have
some benefit in being able to slow their accumulation or reduce
what’s
already there.†Curcumin inhibits endoplasmic reticulum stress
Experimental
and Therapeutic Medicine, September
2017
The aim of the present study was to observe the dynamic changes of the
growth
arrest and DNA damage‑inducible 153 (GADD153) gene and caspase‑12
in the
brain tissue of rats with cerebral ischemia‑reperfusion injury (CIRI)
and the
impact of curcumin pretreatment. A total of 60 rats were randomly
divided into
the normal group (N), the sham operation group (S), the dimethyl
sulfoxide
control group (D) and the curcumin treatment group (C). For group D and
C, 12
(T1), 24 (T2) and 72 h (T3) of reperfusion were performed after 2 h
ischemia.
The expression levels of GADD153 and caspase‑12 in the brain tissue
were
detected and compared among the groups by immunohistochemistry,
immunofluorescence double staining and western blotting. The expression
levels
of GADD153 and caspase‑12 were increased at T1compared with groups N
and S,
and the expression of caspase‑12 peaked at T2 in group D, while
GADD153 was
increased until T3 in group D. Compared with group D, the expression
levels of
GADD153 and caspase‑12 in group C at T2 and T3 were significantly
decreased
(P<0.05). Endoplasmic reticulum stress is involved in the
pathological process
of CIRI. Curcumin may decrease the expression levels of the above two
factors,
thus exhibiting protective effects against CIRI in rats. Can curry
spice really
help banish your aches and pains? Yes - and women may benefit from
nature's
painkiller the most DailyMail, September
2017
Curcumin is a strong anti-inflammatory agent and chronic inflammation
is the
precursor of the vast majority of cancers.,,Turmeric helps cells
regulate their
growth and survival, including the recycling of worn out cells, and the
self-destruction of abnormal cells which have the potential to form
tumours.
Turmeric is traditionally used to support weight loss. Curcumin boosts
the
metabolic rate of ‘good’ brown fat cells so they burn more fat as a
fuel
– this is one reason why you may find yourself sweating after eating a
spicy
curry.,,The latest news is that curcumin also helps to regulate the
production
of hormones linked with obesity, such as resistin (which links obesity
with
insulin resistance and type 2 diabetes), leptin (the satiety hormone)
and
adiponectin (a hormone involved in fat breakdown). Curcumin has
beneficial
effects against skin inflammation by quenching free radicals, reducing
inflammation.,,In psoriasis, this helps to slow the over-production of
cells
that lead to plaque formation. Curcumin Alleviates the Functional
Gastrointestinal Disorders of Mice In Vivo Journal of Medicinal Food,
September
2017
Curcumin is a natural polyphenol extracted from the turmeric rhizome,
which has
a wide range of biological activities, but until now the effects of
curcumin on
the gastrointestinal peristalsis have not been fully understood. In
vivo study,
we observed the effects of curcumin on gastric emptying and intestinal
propulsion rates of mice in normal state and in delayed state by
atropine (ATR)
or nitric oxide precursor L-arginine (L-Arg). An in vitro study
explored the
direct effects of curcumin on the intestinal contractility, but were
studied
through measuring spontaneous contraction of isolated jejunum of mice.
Our
results showed that intragastric administration of curcumin
(200 mg/kg/day)
for 10-20 days significantly improved gastric emptying and intestinal
propulsion rates of mice delayed by ATR. Moreover, intragastric
administration
of curcumin (200 mg/kg/day) for 15 days also significantly improved
mice
gastric emptying and intestinal propulsion rates delayed by L-Arg.
Potential
Role of Curcumin Against Biofilm-Producing Organisms on the Skin: A
Review
Phytotherapy Research, September
2017
Turmeric root (Curcuma longa) is predominantly used as a spice, but has
also
long been known to possess antimicrobial, analgesic, antiinflammatory,
and
anticancer properties. One predominant group of active compounds in
turmeric
are curcuminoids, namely bright yellow-pigmented curcumin. While modern
science
has yet to fully investigate the therapeutic claims of turmeric and its
derivatives, results have proven promising in decreasing pain and
inflammation
in arthritis, improving insulin sensitivity in diabetes, and even
curing a
variety of infections. Curcumin has demonstrated bactericidal efficacy
against
a variety of infections when administered with antibiotics in several
clinical
studies, with consistent antimicrobial activity demonstrated in vitro,
as well
as in urinary tract infections, gingival infections, and chronic wound
infections. Hypothesized mechanisms of action include curcumin's
ability to
perturb bacterial membranes, disturb protofillament assembly, and even
impair
bacterial virulence factors. Shield against Alzheimer's dementia Times
of
India, September
2017
"Turmeric contains a curcumin, the bright yellow chemical that gives
turmeric
its colour, which acts like a protective shield towards the problem,"
he added.
There is a great body of evidence to prove the positive impact of
turmeric on
prevention and treatment of AD. As per
Antioxidants-2016
- an academic publication of Multidisciplinary Digital Publishing
Institute
(open-access publisher), termed turmeric as an alternative therapy for
AD.
Similarly, London based Alzheimer's society noted that curcumin in
turmeric can
break down Amyloid-beta plaques (amino acids that play a key role in
development of dementia). Health Benefits of Turmeric: 5 Proven
Benefits of
Turmeric India.com September
2017
Curcumin present in turmeric improves the brain function by boosting
Brain-Derives Neurotrophic Factor (BDNF), a growth hormone present in
the
brain. It drives the process of formation of new neuron connections.
Neurons
develop new connections in a specific area of the brain. Turmeric also
helps
lower the risk of brain diseases by boosting BDNF in the brain. The
increased
levels of BDNF delays or reverses several age-related brain damages and
brain
diseases. Turmeric contains curcumin, which is beneficial for your
heart.
Curcumin improves your heart health by improving the function of the
blood
vessel lining called endothelium. According to some studies, curcumin
improves
the endothelium function. Studies showed that it is as effective as the
drug
Atorvastatin or works as well as exercises. Curcumin also reduces
oxidation and
inflammation, which in turn improve the heart health. Long-term
stabilisation
of myeloma with curcumin British Medical Journal, August
2017
Here, we describe a myeloma patient who started a daily dietary
supplement of
curcumin when approaching her third relapse. In the absence of further
antimyeloma treatment, the patient plateaued and has remained stable
for the
last 5 years with good quality of life. Curcumin is a polyphenol
derived from
the perennial herb Curcuma longa (turmeric) and has, for centuries,
been used
as a traditional Indian medicine. Several reports published over the
two
decades have claimed various health benefits of curcumin and this has
led to
its increasing popularity as a dietary supplement to prevent or treat a
number
of different diseases. The biological activity of curcumin is indeed
remarkable. It is a highly pleiotropic molecule which possesses natural
antioxidant, anti-inflammatory, antiseptic and analgesic properties.
More
recently, it has demonstrated antiproliferative effects in a wide
variety of
tumour cells including myeloma cells and exerts its antiproliferative
effects
through multiple cellular targets that regulate cell growth and
survival. New
science confirms curcumin every day reverses cancer Natural News,
August
2017
A report in the British Medical Journal illustrates how a woman has
beaten
blood cancer with the help of turmeric. In
2007
, 67-year-old Dieneke Ferguson was diagnosed with myeloma and she
progressed to
stage three within 15 months. Three failed rounds of chemotherapy and
four
failed stem cell transplants later, doctors told her she had very
little hope.
Four years after her initial diagnosis, she took matters into her own
hands and
started taking a daily dose of curcumin, the key component of turmeric.
She
took eight grams every evening on an empty stomach. Since then, her
cancer has
stabilized and her blood counts have returned to normal. The BMJ report
says
that Ferguson’s results suggest that turmeric could be used to help
myeloma
patients in the future, adding: “The fact that our patient, who had
advanced
stage disease and was effectively salvaged while exclusively on
curcumin,
suggests a potential antimyeloma effect of curcumin.†No other
possible
explanation for her recovery. The report’s co-author, Jamie Cavenagh,
said
that there is no other possible explanation for her remarkable recovery
beyond
the curcumin. She continues to take the tablets to this day. The
scientists are
recommending further evaluation in clinical trials to pursue the
possibility of
using it as an official treatment. This could prove difficult, however,
because
doctors cannot prescribe it until it has been tested in wide-scale
trials that
cost millions. Natural compounds cannot be patented, so finding an
investor
would be extremely difficult. Turmeric helped cancer patient, 57, beat
myeloma
after five years of treatment The Sun, August
2017
Dieneke Ferguson took eight grams of curcumin each night for five years
and her
cancer has remained stable. Curcumin is a polyphenol derived from the
perennial
herb turmeric and has been used as a traditional Indian medicine for
centuries.
Curcumin is a natural antioxidant, anti-inflammatory, antiseptic and
has
analgesic properties, according to the BMJ report. More recently, it
has
demonstrated an ability to slow or inhibit cell growth in a wide
variety of
tumour cells, including myeloma. It has also been found to help
alleviate a
range of other health problems. Turmeric may help fight the most common
type of
cancer found in infants Mic.com August
2017
A popular spice frequently used in curries may be combatting the most
common
cancer cells afflicting infants, according to a recent study. Turmeric,
a
vibrant yellow spice seen in dishes such as roasted vegetables and
soups,
contains a chemical called curcumin. Recent research suggests that
curcumin
helps destroy neuroblastoma tumor cells, which often start in the
embryo or
fetus. These particular tumor cells can become resistant to drug
treatments,
scientists say, meaning that a new treatment plan involving turmeric
could make
all the difference. For children, neuroblastoma can be a severe health
obstacle. About 700 new cases appear each year in the U.S., mostly
diagnosed in
kids younger than age 5. This type of cancer can delay development and
cause
hearing loss or other disabilities. That aside, the medical treatment
itself
can be difficult: Kids can suffer serious side effects or damage from
traditional methods such as chemotherapy, for example. “This research
demonstrates a novel method of treating this tumor without the toxicity
of
aggressive therapy that can also have late effects on the patient’s
health,†Tamarah J. Westmoreland, a lead researcher on the study,
said in a
release. Chemical from turmeric helps treat cancer in children: Study
TheHindu.com August
2017
Scientists in the U.S. have found yet another use for curcumin, the
bioactive
component of turmeric that is widely used in Indian cuisine, this time
to treat
cancer in children. Researchers at Nemours Children’s Hospital and
the
University of Central Florida (UCF) have found that nanoparticles
loaded with
curcumin can target and destroy neuroblastoma tumour cells. Children
aged five
or less are most commonly affected. In their study, the researchers
attached
curcumin to cerium oxide nanoparticles and tested the nano-curcumin
formulation
in cell lines of a high-risk form of neuroblastoma. “This formulation
induced
substantial cell death in neuroblastoma cells while producing no or
only minor
toxicity in healthy cells,†says the report published in Nanoscale .
Curcumin
has been shown to have substantial anti-cancer ability, but its low
solubility
and poor stability have restricted its use in therapeutic applications.
The
study demonstrates a treatment method “without the toxicity of
agressive
therapy†and shows that nanoparticles can be “an effective delivery
vehicle†for cancer drugs, said a statement from UCF. Starving
Prostate
Cancer With What You Eat for Dinner University of Texas, August
2017
Curcumin combined with other nutrients has anti-cancer properties. The
researchers first tested 142 natural compounds on mouse and human cell
lines to
see which inhibited prostate cancer cell growth when administered alone
or in
combination with another nutrient. The most promising active
ingredients were
then tested on model animals: ursolic acid, a waxy natural chemical
found in
apple peels and rosemary; curcumin, the bright yellow plant compound in
turmeric; and resveratrol, a natural compound common to red grapes or
berries.
“These nutrients have potential anti-cancer properties and are
readily
available,†says Tiziani. “We only need to increase concentration
beyond
levels found in a healthy diet for an effect on prostate cancer
cells.†The
new research paper also demonstrates how the plant-based chemicals work
together. Combining ursolic acid with either curcumin or resveratrol
prevents
cancer cells from gobbling something that they need to grow, glutamine.
This is
a neat solution: blocking the uptake of a nutrient needed by prostate
cancer
cells with nutrients that are commonly in the human diet. Curcumin
attenuates
the development of thoracic aortic aneurysm by inhibiting VEGF
expression and
inflammation Molecular Medicine Reports, August
2017
curcumin exerts a marked effect on aortic aneurysm development. In rat
tissues,
treatment with curcumin resulted in reduced aneurysm size and restored
the wavy
structure of the elastic lamellae. In addition, curcumin decreased
neovascularization and the expression of VEGF. Immunohistochemical
analysis
indicated that curcumin significantly inhibited infiltration of cluster
of
differentiation (CD)3+ and CD68+ cells in TAA. Furthermore, curcumin
treatment
decreased the expression of vascular cell adhesion molecule‑1,
intracellular
adhesion molecule‑1, monocyte chemoattractant protein‑1 and tumor
necrosis
factor‑α. Collectively, the results demonstrated that angiogenesis
and VEGF
expression were increased in the aortic wall in TAA. Treatment with
curcumin
inhibited TAA development in rats, which was associated with
suppression of
VEGF expression. In addition, curcumin attenuated inflammatory cell
infiltration and suppressed inflammatory factor expression in the
periaortic
tissue of TAA. Underlying Mechanisms ID'd in Curcumin Resensitization
of CA
Cells HealthDay News, August
2017
Curcumin can resensitize chemoresistant pancreatic ductal
adenocarcinoma (PDAC)
cells through inhibition of the polycomb repressive complex 2
(PRC2)-PVT1-c-Myc
axis, according to a study published online July 17 in Carcinogenesis.
The
researchers reported the resensitization of chemoresistant PDAC cells
by
curcumin through inhibition of the PRC2-PVT1-c-Myc axis. Curcumin
sensitized
chemoresistant cancer cells inhibited expression of the PRC2 subunit
enhancer
of zeste homolog-2 and its related long non-coding RNA PVT1 using
gemcitabine-resistant PDAC cell lines. Curcumin also prevented spheroid
formation and down-regulated several genes driving self-renewal. In
vitro
findings were confirmed in a xenograft mouse model, with inhibition of
gemcitabine-resistant tumor growth by curcumin. "Overall, this study
establishes clinical relevance for combining curcumin with chemotherapy
to
overcome chemoresistance in PDAC," the authors write. Curcumin
sensitizes
pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit
EZH2, and
the lncRNA PVT1 expression Carcinogenesis, August
2017
Accumulating evidence indicates that curcumin, a phenolic compound
extracted
from turmeric, can overcome de novo chemoresistance and re-sensitize
tumors to
various chemotherapeutic agents. Using gemcitabine-resistant PDAC cell
lines,
we found that curcumin sensitized chemoresistant cancer cells by
inhibiting the
expression of the PRC2 subunit EZH2 and its related lncRNA PVT1.
Curcumin was
also found to prevent the formation of spheroids, a hallmark of CSCs,
and to
down-regulate several self-renewal driving genes. In addition, we
confirmed our
in vitro findings in a xenograft mouse model where curcumin inhibited
gemcitabine-resistant tumor growth. Overall, this study indicates
clinical
relevance for combining curcumin with chemotherapy to overcome
chemoresistance
in PDAC. Kitchen spice helps woman beat cancer israelnationalnews.com
August
2017
Dieneke Ferguson, 67, battled myeloma for five years, thought she had
lost, and
then tried a key component of a common kitchen spice: curcumin. Now,
five years
later, her cancer cell count is negligible, the Daily Mail reported.
Her
recovery was so remarkable it was featured in the British Medical
Journal.
However, the report emphasized that few - if any - of myeloma sufferers
used
curcumin on its own, without conventional treatments. And co-author
Jamie
Cavenagh, who works at London’s Barts Hospital as a specialist in
blood
disease, said many of his patients take curcumin at some point, but it
doesn't
work for everyone. "A lot of my patients take curcumin at different
stages of
their treatment. I don’t object to it," Cavenagh said. " Dieneke’s
is the
best response I have observed and it is clear-cut because we had
stopped all
other treatment. I have not seen such a convincing response before."
"When you
review her chart, there’s no alternative explanation [for her
recovery] other
than we’re seeing a response to curcumin." Myeloma is a type of blood
cancer,
and to treat it, Ferguson first tried three rounds of chemotherapy and
four
stem cell transplants. Ferguson currently takes 8 grams of curcumin a
day
(equivalent to two teaspoons of powered curcumin), mostly to ensure the
disease
does not come back. Cancer breakthrough: Trendy spice could be key to
killing
tumours Express, August
2017
The curcumin chemical in turmeric has shown promise destroying
neuroblastoma
tumour cells. Could a turmeric extract help to treat pancreatic cancer?
Medical
News Today, August
2017
A common obstacle in the treatment of pancreatic cancer is drug
resistance.
However, new research has shown that curcumin - a compound that can be
found in
turmeric - can help to overcome the resistance to chemotherapy.
Curcumin is the
active compound found in plants such as turmeric, and more and more
studies
have been pointing to the therapeutic potential of the compound for
various
conditions, ranging from cancer to diabetes. Preclinical studies have
suggested
that the compound has various antioxidant, neuroprotective,
anti-inflammatory,
and anticarcinogenic properties. "By treating certain cells with small
doses of
curcumin, we were able to reverse the pathways that lead to
chemoresistance,"
says Dr. Goel. "This is an important breakthrough that could lead to
better
prognosis and longer lives for patients with chemoresistant pancreatic
cancer."
Previous studies have shown that curcumin has preventative benefits,
but to the
authors' knowledge, this is the first study that shows the beneficial
effect of
the plant extract in combination with chemotherapy and its advantages
in
overcoming drug resistance. Baylor Scott & White Research Institute
Shows
Curcumin Protects Against Chemoresistant Pancreatic Cancer Healthcare
Magazine,
August
2017
Baylor Scott & White Research Institute scientists found curcumin, a
plant-based medicinal compound, can help overcome chemotherapy
resistance in
pancreatic ductal adenocarcinoma, the country’s fourth leading cause
of
cancer-related deaths. According to researchers, resistance to
chemotherapeutic
drugs is a major challenge for PDAC patients. Initially, patients may
respond
to chemotherapy but, as cancer stem cells form, patients’ bodies may
become
immune to chemotherapy drugs. The Baylor Scott & White study stated
curcumin
can act as an adjunct to chemotherapy to battle this. “By treating
certain
cells with small doses of curcumin, we were able to reverse the
pathways that
lead to chemoresistance,†Dr. Ajay Goel, director of gastrointestinal
research and translational genomics and oncology at Baylor Scott &
White
Research Institute, said in a statement. “This is an important
breakthrough
that could lead to better prognosis and longer lives for patients with
chemoresistant pancreatic cancer.†Goel said his team had identified
two key
players in regulating drug resistance. Researchers found that when
pancreatic
cancer cells were treated with curcumin, the natural compound inhibited
pathways associated with chemotherapy drug resistance—increasing
reception to
first-line drug therapy. Researchers also found curcumin can prevent
the
formation of spheroids, in turn reducing tumor growth and recurrence.
Currently, Goel and his research team are continuing to explore the
benefits of
curcumin. There are clinical trials underway studying the role of
curcumin in
cervical, breast, and colorectal cancers. Curcumin Compound in Turmeric
May be
Used to Help Fight Cancer in Children: Scientists NDTV.com, August
2017
A team of scientists from the United States of America have found that a
bioactive compound in turmeric known as curcumin can also cure cancer
in
children. Neuroblastoma is one of the most common cancers in children
below the
age of five years. The cancer starts in early nerve cells and commonly
forms in
the tissue of the adrenal glands, near the kidneys. It is also
associated with
developmental delays, hearing loss and other disabilities. Turmeric can
be used
to fight cancer in children, find US scientists Economic Times, August
2017
Researchers at Nemours Children's Hospital and the University of
Central
Florida (UCF) have recently found that the nanoparticles loaded with
curcumin
can offer a novel treatment to target and destroy neuroblastoma tumor
cells.
Wound healing activity of curcumin conjugated to hyaluronic acid: in
vitro and
in vivo evaluation. PubMed, August
2017
Studies on proliferation, antioxidant activity and scratch wound
healing
carried out in human keratinocyte cells revealed that HA-conjugated
curcumin
treatment enhanced cell proliferation, decreased oxidative damage
induced by
H2O2 and also improved migration of cells in scratch wounds as compared
to
treatment with native curcumin. HA conjugated curcumin exhibited
bactericidal
activity in dark and phototoxicity when irradiated with blue light
against
antibiotic resistant bacteria. Furthermore, wound healing efficacy
studied in
diabetic mice demonstrated that topical application of the conjugate on
wounds
led to better healing as compared to treatment with HA-free curcumin
and HA
alone. These results suggest that HA conjugation is a promising
formulation of
curcumin for enhancing its healing efficacy. Researchers Show Curcumin
Protects
Against Chemoresistant Pancreatic Cancer NewsWise.com August
2017
Curcumin is known for its powerful anti-inflammatory and antioxidant
benefits,
but a new study by researchers at Baylor Scott & White Research
Institute
reveals an additional benefit: its potential to overcome
chemoresistance in
pancreatic ductal adenocarcinoma (PDAC), a common but aggressive form
of cancer
in the pancreas. The study, “Curcumin sensitizes pancreatic cancer
cells to
gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1
expression,†recently was published in Carcinogenesis, an integrative
cancer
research journal. Previous research demonstrated the advantages of
taking
curcumin preventatively, but this is the first study of its kind to
demonstrate
benefits of curcumin as an adjunct to chemotherapy. Resistance to
chemotherapeutic drugs is a major challenge in caring for patients with
PDAC,
the fourth leading cause of cancer-related U.S. deaths. Patients may
respond to
chemotherapy initially, but as cancer stem cells form, the body can
develop
drug resistance. Now, researchers have developed an improved
understanding of
the molecular events underlying the development of pancreatic stem
cells and
the role that curcumin—the main component of turmeric—plays in
overcoming
resistance to vital chemotherapy drugs. Curry spice helped woman, 67,
to beat
blood cancer Metro, August
2017
Dieneke Ferguson, 67, thought she had exhausted all options available
after
undergoing three rounds of chemotherapy and four stem cell transplants
as she
battled myeloma. However, she then turned to a product called curcumin,
which
is an ingredient of the spice turmeric, and her recovery was so
incredible it
has been featured in the British Medical Journal. Although curcumin
features in
kitchen turmeric, it only makes up around 2%, so Dieneke takes the
ingredient
in tablet form so she can get 8g a day. After five years of taking the
tablet,
that she heard about on a cancer support group, her cancer cell count
is
negligible. The Benefits Turmeric Has on Your Skin The Weekly
Challenger,
August
2017
Scientific studies as recent as
2017
preach the anti-inflammatory and wound-healing properties of turmeric,
due to
the curcumin inside the plant. Other studies have found that turmeric
can help
reduce skin damage, including damage due to sun exposure, pollution,
smoking,
aging, and acne. How curry spice helped a dying woman beat cancer:
Sufferer,
67, turned to kitchen cupboard staple turmeric after five years of
failed
treatment Mail Online, August
2017
How curry spice helped a dying woman beat cancer: Sufferer, 67, turned
to
kitchen cupboard staple turmeric after five years of failed treatment.
Dieneke
Ferguson was diagnosed with the blood cancer myeloma in
2007
and underwent three rounds of chemotherapy as well as four stem cell
transplants. She tried Curcumin, a component of turmeric, and five
years on,
her cancer cell count is negligible, with her recovery featuring in the
British
Medical Journal. Curcumin has been linked to a host of benefits,
including for
heart disease. 5 Foods That Help Fight Cancer The Quint, August
2017
Curcumin (turmeric extract) works brilliantly with cancer patients and
balances
the side effects of chemo by boosting immunity. Its highly
anti-microbial and
anti-inflammatory and that helps because cancer is an inflammatory
disease.
Synergistic Interplay between Curcumin and Polyphenol-Rich Foods in the
Mediterranean Diet: Therapeutic Prospects for Neurofibromatosis 1
Patients
Nutrients, August
2017
After six months, patients adopting a traditional MedDiet enriched with
1200 mg
curcumin per day presented a significant reduction in the number and
volume of
cutaneous neurofibromas; these results were confirmed in subsequent
evaluations. Notably, in one patient, a large cranial plexiform
neurofibroma
exhibited a reduction in volume (28%) confirmed by Magnetic Resonance
Imaging.
We hypothesize that the combination of a polyphenol-rich Mediterranean
diet and
curcumin was responsible for the beneficial effect observed on NF1.
This is, to
the best of our knowledge, the first experience with curcumin
supplementation
in NF1 patients. Our report suggests that an integrated nutritional
approach
may effectively aid in the management of NF1. The best immune
system-boosting
foods Coach, August
2017
A component of turmeric called curcumin, which gives the spice its
orange-yellow colour, has been shown to have a potent stimulatory
effect on the
immune system. A study carried out by American and Chinese researchers
last
year found the consumption of curcumin resulted in the body producing
more
white blood cells, which then removed a tuberculosis causing bacteria
from
infected cells. Family Living Focus: Turmeric Lancaster Farming, August
2017
Curcumin, the active substance in turmeric, is a powerful antioxidant.
Antioxidants aid against cell damage. Curcumin lowers the level of two
enzymes
in the body that cause inflammation. Curcumin stops platelets from
clumping
together to form blood clots. Curcumin has been found to reduce the
symptoms of
bloating and gas in people suffering with indigestion. Curcumin
converts Foxp3+
regulatory T cells to T helper 1 cells in patients with lung cancer
Journal of
Cellular Biochemistry, August
2017
The effect of curcumin on inhibiting cancer has been recognized, but
the
mechanism remains elusive. This study tests a hypothesis that
administration of
curcumin down regulates Tregs in lung cancer (LC) patients. In this
study, a
group of LC patients was treated with curcumin. The peripheral Tregs
and T
helper (Th) 1 cells were analyzed by flow cytometry. The mechanism by
which
curcumin regulated the Tregs was observed by cell culture approaches.
The
results showed that the frequency of peripheral Treg was markedly
higher in LC
patients than that in healthy subjects, which was suppressed after
treating
with curcumin for 2 weeks. The peripheral Th1 cells were increased in
LC
patients after the curcumin therapy. The data of the in vitro
experiments
showed that curcumin converted the LC patient-isolated Tregs to Th1
cells via
repressing the gene transcription of forkhead protein-3 and increasing
the
expression of interferon-γ. In conclusion, curcumin can convert LC
patient-isolated Tregs to Th1 cells. The results suggest that curcumin
may
improve the antitumor immunity by regulating the tumor specific immune
tolerance. Compounds in Apples, Grapes and Other Plant Foods Stop
Prostate
Cancer in Mice, Study Shows Prostate Cancer News, July
2017
Researchers tested 142 natural compounds in food for
prostate-cancer-fighting
properties. They discovered that combinations of ursolic acid,
resveratrol and
curcumin stopped the disease. Ursolic acid is found in apple peels and
the herb
rosemary, resveratrol in red grapes and berries, and curcumin in the
spice
turmeric. The study, “Combinatorial treatment with natural compounds
in
prostate cancer inhibits prostate tumor growth and leads to key
modulations of
cancer cell metabolism,†was published in the journal npj Precision
Oncology.
To start with, the University of Texas researchers tested the compounds
on
prostate cancer cells in a lab. They evaluated the substances alone and
in
combinations. When the team discovered that ursolic acid, resveratrol
and
curcumin might inhibit prostate cancer growth, they tested all possible
combinations of the compounds in mice with prostate cancer. Some
combinations
prevented tumor growth in the animals, with no toxic effects.
Scientists
already know that chemicals in apple peels, turmeric and green tea
reduce
inflammation, a risk factor for cancer because it damages normal cells.
The
researchers also wanted to know how the compounds inhibited tumor
growth. They
studied metabolic pathways, or chemical transformations needed to
nourish
cancer cells. They found that ursolic acid, combined with either
resveratrol or
curcumin, kept cancer cells from consuming glutamine, a compound the
cells need
to grow. Denying the cells glutamine starved them. Natural Compounds in
Ordinary Foods Beat Prostate Cancer News Max, July
2017
They first tested 142 natural compounds on mouse and human cell lines
to see
which inhibited prostate cancer cell growth when administered alone or
in
combination with another nutrient. The most promising active
ingredients were
then tested on model animals: ursolic acid, a waxy natural chemical
found in
apple peels and rosemary; curcumin, the bright yellow plant compound in
turmeric; and resveratrol, found in red grapes and berries.,,The found
that
when combined with either curcumin or resveratrol, ursolic acid
prevented the
uptake of glutamine, a nutrient necessary for cancer growth.,,"These
nutrients
have potential anti-cancer properties and are readily available," says
Stafano
Tiziani. Combinations of the nutrients, he says, "have a better effect
on
prostate cancer than existing drugs.,,"The beauty of this study is that
we were
able to inhibit tumor growth in mice without toxicity," Tiziani
said.,,The
study was published in Precision Oncology. Pre-treatment with curcumin -
a safe
herbal compound derived from turmeric – makes cancer stem cells
sensitive to
radiation therapy. Down To Earth, July
2017
The study builds upon earlier findings that pre-treatment with curcumin
- a
safe herbal compound derived from turmeric – makes cancer stem cells
sensitive to radiation therapy. It has found that combined effect of
curcumin
and exposure to radiation was markedly more effective in lowering AP-1
levels
thereby rendering cells unviable for growth and replication. When
treated with
radiation alone, there was delayed but increased rate of proliferation
and
tumor formation. The mechanism of curcumin-induced inhibition lends
credibility
to AP-1 as a drug target and therapeutic utility of curcumin for
radio-sensitization of cervical cancer stem cells for better treatment
outcomes. Natural Ways to Lower Your Cholesterol FitCommerce.com July
2017
Turmeric, the spicy yellow ingredient found in Indian food, contains
the active
ingredient, curcumin. Recent research suggests that curcumin may reduce
cholesterol by interfering with intestinal cholesterol uptake,
increasing the
conversion of cholesterol into bile acids, and increasing the excretion
of bile
acids. Curcumin has powerful antioxidant and anti-inflammatory
properties and
may help prevent the oxidation of LDL cholesterol to a more dangerous
form that
is more likely to end up in your arteries. Curcumin protects against
acute
renal injury by suppressing JAK2/STAT3 pathway in severe acute
pancreatitis in
rats Experimental and Therapeutic Medicine, July
2017
The results showed that curcumin significantly decreased serum amylase,
Cr and
BUN levels, and alleviated pancreatic and renal histological changes in
SAP
rats. Furthermore, curcumin markedly decreased serum TNF‑α and
IL‑6 levels
and downregulated renal protein levels of JAK2/STAT3 pathway
components. These
results proved that curcumin ameliorates acute renal injury in a rat
model of
SAP. The molecular mechanism of its effect may be associated with the
suppression of the JAK2/STAT3 pathway to reduce TNF‑α and IL‑6
levels in
SAP‑induced acute renal injury. Therefore, the findings of the
present study
revealed the potential use of curcumin for the prevention and treatment
of SAP
and the associated renal injury. Prostate Cancer Cells Can Be Treated
With
Natural Compounds Present In Apple, Red Grape & Turmeric The
Science Times,
July
2017
The researchers performed the tests of the compounds individually and
also in
combination. They identified three key compounds that played
effectively in
halting the growth of the prostate cancer cells. The three effective
compounds
are curcumin, ursolic and resveratrol. A bright yellow curcumin is a
natural
compound present in turmeric, and ursolic acid can be found in the
apple peel.
Another important natural compound resveratrol is present in berries
and red
grapes. The researchers combined the ursolic acid with either
resveratrol or
curcumin and tested it in the mice with induced prostate cancer. They
noticed
that the compounds stopped the necessary uptake of the important amino
acid
glutamine by the prostate cancer cells. The uptake of this amino acid
helped
the prostate cancer cells to grow. Now the prevention of the
glutamine's uptake
forced the cells to starve. This starvation ultimately led to the death
of the
prostate cancer cells and simultaneously halted the growth of the tumor
in the
mice. One important fact is natural compounds curcumin, resveratrol,
and
ursolic acid caused no toxic effects on mice. The researchers found
that the
concentrations of the natural compounds in the mice were higher than
they are
normally present and consumed through the diet. However, the findings
of the
study have indicated promising outcome to prevent and treat the
prostate cancer
cells. Life-Changing Benefits Of Turmeric Elite Daily, July
2017
Studies show that, in India, diagnoses of Alzheimer's disease are
pretty low,
and it appears to be due to turmeric's major role in the Indian diet.
Curcumin
helps to improve working memory, as well as attention span and mood in
elderly
adults. According to a
2014
study, 60 healthy adults showed significantly improved performance on
attention
and working memory tasks only one hour after receiving a single dose of
400 mg
of curcumin, compared with those who received a placebo. Curcumin can
kill
damaged cells while still leaving other cells healthy and intact,
unlike
chemotherapy. According to GreenMedInfo, turmeric reduces post-bypass
heart
risk by 56 percent. Not only that, but the effects it has on heart
health are
similar to the effects that aerobic exercise has on heart health, and
it
improves vascular function in post-menopausal women. Curcumin can
possibly be
just as effective as an antidepressant.Its work with depression is
related to
its anti-inflammatory properties because people with depression have
greater
inflammation and oxidative stress, which can affect all major organs in
the
body, including the brain, according to Psychiatry Advisor. Apples and
Curry
May Starve Prostate Cancer Cells Vital Updates, July
2017
The study authors discovered cancer-limiting effects with curcumin,
which is
found in the “wonder spice†turmeric, as well. “These nutrients
have
potential anti-cancer properties and are readily available,†said
corresponding author Stefano Tiziani, assistant professor in the
Department of
Nutritional Sciences and Dell Pediatric Research Institute at
University of
Texas at Austin. One of the most important findings that the
researchers
uncovered was how chemical combinations could limit glutamine
metabolism in
cancer cells, which need the substance to survive. Specifically, the
researchers found that combining ursolic acid with resveratrol or
curcumen made
the biggest impact. Targeting multiple pro-apoptotic signaling pathways
with
curcumin in prostate cancer cells PLoS One, July
2017
The mechanisms by which curcumin promoted cell death in these cells
were
associated with cell cycle arrest, increased reactive oxygen species,
autophagy
and the Unfolded Protein Response. Furthermore, the upregulation of ER
stress
was measured using key indicators of ER stress: Glucose-Regulated
Protein 78,
Inositol-Requiring Enzyme 1 alpha, Protein Disulfide isomerase and
Calreticulin. Chronic ER stress induction was concomitant with the
upregulation
of pro-apoptotic markers (caspases 3,9,12) and Poly (ADP-ribose)
polymerase.
The downregulated proteins include anti-apoptotic and anti-tumor
markers,
supporting their curcumin-induced pro-apoptotic role in prostate cancer
cells.
Taken together, these data suggest that curcumin may serve as a
promising
anticancer agent by inducing a chronic ER stress mediated cell death
and
activation of cell cycle arrest, UPR, autophagy and oxidative stress
responses.
Relieve Pain Naturally The Alternative Daily, July
2017
Curcumin is now one of the most effective anti-inflammatory agents
known to
man, and you’ll see curcumin supplements on most health store shelves
across
the globe. Ancient civilizations came to refer turmeric, and hence
it’s
active ingredient curcumin, as an almost holy plant, in large part
because of
it’s amazing healing powers. Curcumin works by regulating cytokines,
proteins
and enzymes that are linked to inflammation. This has lead many
scientists to
conclude that curcumin may be one of the most effective ways to treat
chronic
neurodegenerative, cardiovascular, metabolic and neoplastic diseases.
Curcuminoids modify lipid profile in type 2 diabetes mellitus: A
randomized
controlled trial Science Direct, July
2017
Curcuminoids supplementation can reduce serum levels of atherogenic
lipid
indices including non-HDL-C and Lp(a). Therefore, curcuminoids
supplementation
could contribute to a reduced risk of cardiovascular events in
dyslipidemic
patients with T2D. Curcumin reduces hippocampal neuron apoptosis and
JNK-3
phosphorylation in rats with Aβ-induced Alzheimer's disease:
protecting
spatial learning and memory Journal of Neurorestoratology, July
2017
Curcumin relieved spatial learning and memory deficits, hippocampus
neuronal
apoptosis, and reduced JNK-3 and p-JNK-3 levels (all P<0.05). In
conclusion,
curcumin may inhibit JNK-3 phosphorylation to protect against
hippocampal
neuron apoptosis after Aβ injection. Topical Curcumin for Precancer
Cervical
Lesions ClinicalTrials.gov July
2017
The purpose of this study is to see if curcumin can reverse a cervical
precancerous state by looking at people who have the condition and
intervening
with a study drug or placebo (an inactive drug), prior to planned
therapeutic
loop electrosurgical excision procedure (LEEP) which is a treatment
procedure
for removing cervical cancer. Curcumin induced autophagy anticancer
effects on
human lung adenocarcinoma cell line A549 Oncology Letters, July
2017