"Curcumin has a long established safety record. For example, according to JECFA (The Joint United Nations and World Health Organization Expert Committee on Food Additives) and EFSA (European Food Safety Authority) reports, the Allowable Daily Intake (ADI) value of curcumin is 0–3 mg/kg body weight. Several trials on healthy subjects have supported the safety and efficacy of curcumin." - Curcumin, an active component of turmeric (Curcuma longa), and its effects on health | Critical Reviews in Food Science and Nutrition
"Curcumin has been one of the most studied herbal remedies, attracting strong pharmaceutical attention due to its diverse biological activities. Curcumin is one of the most studied phytochemicals used as anticancer molecules. This polyphenol has been used in traditional medicine in Asia since ancient times and it has been shown to have extensive cytotoxic effects against cancer cells. In addition, curcumin has also shown beneficial and protective functions in acute myocardial infarction and cardiovascular diseases, chronic atherosclerosis, neurodegenerative diseases and autoimmune diseases. Interest in curcumin has gradually increased after several studies demonstrated its chemotherapeutic and chemopreventive effects." - International Journal of Molecular Sciences | 2023
"Curcumin is the most important chemical component of turmeric, which can exert antioxidant, anti-inflammatory, anti-angiogenic and anti-tumor pharmacological effects without significant adverse effects. Studies have shown that curcumin and curcuminoids in turmeric could provide good protection against many chronic diseases in the body by inhibiting inflammatory responses, lowering blood lipids, and improving blood sugar. Curcumin in turmeric can effectively inhibit inflammatory reactions and reduce symptoms such as pain and swelling. In recent years, it was found that curcumin could alleviate some symptoms in some autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease" - Frontiers in Immunology | 2023
"For thousands of years, turmeric has been used to treat common colds, fevers, stomachaches, liver diseases, open wounds, skin diseases, and chronic inflammations. After epidemiological studies, turmeric may have the ability to lower cancer incidence rates by 10-50% among those who regularly consume the spice. Considered pharmacologically safe, curcumin possesses various effects, including antioxidant, anti-inflammatory, and anti-septic properties, and also modifies its influence on the expression of genes involved in cytotoxicity, angiogenesis, metastasis, and drug resistance. Curcumin mediates its promising activities by regulating several key molecular targets." - International Journal of Biological Sciences | 2023
"Curcumin is characterized by many desirable properties. It has anti-inflammatory, antioxidant, and anticancer properties, among others. Furthermore, importantly, it is safe and rarely causes adverse symptoms. For this reason, it is used to treat or support the treatment of many diseases, e.g., cardiovascular diseases, inflammatory bowel diseases, breast, stomach, pancreatic and lung tumors, dermatoses, allergic asthma, and liver diseases." - International Journal of Environmental Research and Public Health | 2023
"According to the results of preclinical and clinical studies conducted in vitro and in vivo, curcumin may be helpful in the prevention and treatment of many diseases, including cardiovascular diseases, diabetes mellitus, obesity, allergy, asthma, inflammatory diseases, and neurodegenerative disorders, e.g., Alzheimer’s, Parkinson’s, multiple sclerosis, and Huntington’s disease by affecting different molecular targets. Over the few current decades, considerable studies have been conducted on curcumin due to its beneficial health properties, including potent antioxidant properties, antimicrobial, anti-inflammation, anticancer effects, cardio-protectiveness, and hypoglycemic action. Compared to other medications, curcumin is viewed as a very cost-effective and safe natural substance that can be used to prevent and treat many disorders." - Impacts of turmeric and its principal bioactive curcumin on human health: A comprehensive review | 2023
"Research suggests that curcumin can help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety,,and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and subsequent performance in active people. In addition, a relatively low dose can provide health benefits for people that do not have diagnosed health conditions." - Department of Nutrition, Central Michigan University | 2023
"Curcumin has been approved as a food additive by the World Health Organization and the US Food and Drug Administration and has been listed as a third-generation cancer chemoprevention drug by the National Cancer Institute of the United States due to its safety, non-toxicity, and lack of adverse effects." - Curcumin Targeting Non-Coding RNAs in Colorectal Cancer: Therapeutic and Biomarker Implications, Biomolecules | 2022
"Curcumin may not fit medical chemists’ definition of the perfect drug, but many in vitro, in vivo and clinical trials have irrefutably confirmed its medicinal potential. Curcumin, as a natural product with low price, has received increasing attention in recent years. Many studies have indicated that it has multiple biological activities." - Frontiers in Pharmacology | 2022 "Curcumin has been selected as a third-generation cancer chemopreventive agent by the National Cancer Institute" - Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review | 2022
"One of the most commonly used herbal supplements is curcumin, which has been extensively studied in cancer prevention and treatment. In fact, a plethora of preclinical studies have demonstrated the anti-cancer properties of curcumin as well as its role as a chemosensitizer agent." - International Journal of Molecular Sciences | 2022
"Curcumin, the key bioactive phytochemical present in turmeric (Curcuma longa L.), is the most studied natural compound in cancer. Preclinical studies (in vitro and in vitro) and clinical trials have demonstrated curcumin's effectiveness as an anti-inflammatory agent. The existing evidence supports that curcumin inhibits the proliferation of many types of cancer cells related to the effect on different types of cancers, such as chronic myeloid leukemia, multiple myeloma, prostate, colorectal and pancreatic cancer as well as cancer therapy-related complications, including oral mucositis and radiation dermatitis." - The golden spice curcumin in cancer: A perspective on finalized clinical trials during the last 10 years, Journal of Cancer Research and Therapeutics | 2022
"Curcumin, the active ingredient of Curcuma longa L., is the most studied compound described as a potential anticancer agent due to its multi-targeted signaling/molecular pathways." - Frontiers in Pharmacology | 2022
"The most extensively studied plant material is turmeric, Curcuma longa, which is the chief source of curcumin. Based on the findings, it can be said that curcumin, a natural substance, has good therapeutic qualities when it is isolated." - Applied Biochemistry and Biotechnology | 2022
"Curcumin, a multi-targeted compound, has traditionally been used as a dietary spice and a medicinal herb in Asian countries for a variety of pathologies due to its anti-inflammatory properties, and antioxidant properties. Moreover, curcumin possesses antibacterial, antiviral, antifungal, anti-arthritic, hepatoprotective, anti-thrombotic, cardio-protective, hypoglycemic, anti-allergic, wound-healing, and chemo-preventive and anticancer properties. Curcumin’s anti-inflammatory and antioxidant effects, among others, form the basis of curcumin’s critical neuroprotective effects in a variety of neurological diseases affecting both the central and peripheral nervous systems. Several molecular targets of curcumin have been identified based on extensive evidence from in vitro and in vivo studies." - Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature | 2021
"During the last decade, pharmacokinetics, pharmacodynamics and pharmacological properties of curcumin, a yellow-orange polyphenolic compound, have been extensively studied. Significant antitumor, antioxidant, antiviral, lipid-lowering, chemopreventive, hepatoprotective and neuroprotective properties of curcumin have been confirmed. Recent studies have also confirmed the pharmacological activity of curcumin as anti-inflammatory and immunomodulatory agent. Due to its pronounced anti-inflammatory activity, curcumin is considered to be a potential mediator of accelerating the healing process." - Curcumin: Natural Antimicrobial and Anti Inflammatory Agent, Journal of Pharmaceutical Research International | 2021
"We found 12,595 papers on curcumin and 4738 on curcumin and cancer; that means 37% of the published papers on curcumin has cancer as the major targeted disease. The therapeutic benefits of curcumin have been demonstrated in multiple chronic diseases: inflammation, arthritis, metabolic syndrome, liver disease, obesity, neurodegenerative diseases and, above all, in several cancers." - Nutrients Journal "Most studies have classified curcumin as a non-toxic and safe material with a safe dose for human clinical trials greater than 120 mg/m2" - Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential | Biomedicine & Pharmacotherapy
"Curcuminoids have been approved by the US Food and Drug Administration (FDA) as “Generally Recognized As Safe” (GRAS), and good tolerability and safety profiles have been shown by clinical trials, even at doses between 4000 and 8000 mg/day and of doses up to 12,000 mg/day of 95% concentration of three curcuminoids: curcumin, bisdemethoxycurcumin, and demethoxycurcumin." - Curcumin: A Review of Its’ Effects on Human Health
"A phase 1 human trial with 25 subjects using up to 8000 mg of curcumin per day for 3 months found no toxicity from curcumin. Five other human trials using 1125-2500 mg of curcumin per day have also found it to be safe." - The Journal of Alternative and Complementary Medicine
"Patients received 8 grams curcumin by mouth daily, no toxicities were observed. Phase II trial demonstrates that 8 g/day curcumin for 2 months is well tolerated and exhibits biological effects in patients with advanced pancreatic cancer. " - Phase II trial of curcumin in patients with advanced pancreatic cancer | Clinical Cancer Research
"Oral curcumin 6 g/day for 4–7 weeks during radiotherapy reduced the severity of radiation dermatitis without any toxicity in breast cancer patients." - Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients | Radiation Research
"Studies on human did not show toxic effects, and curcumin was safe at the dose of 6 g/day orally for 4-7 weeks. Curcumin is known as a generally recognized as safe substance. Turmeric and curcumin are nontoxic for human especially in oral administration. Based on the numerous experimental and clinical evidences, curcumin is well tolerated in humans without significant side effects." - Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances | Phytotherapy Research
"3.6 g/day oral curcumin for 6 months was well tolerated and safe in leucoplakia patients demonstrating significant clinical response." - A Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia | Cancer Prevention Research
"Phase I trials reported that curcumin extract in doses between 440 and 2200 mg/day for up to 4 months was well tolerated and is devoid of dose limiting toxicity in patients with advanced colorectal cancer, substantiating the safety of curcumin." - Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer | Clinical Cancer Research
"Therapy using 8000 mg oral curcumin daily was safe and feasible in patients with pancreatic cancer." - A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer | Cancer Chemotherapy and Pharmacology
"Curcumin at a dose of 2 g/day for 6 months as oral maintenance therapy proved to be safe in patients with ulcerative colitis." - Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial | Clinical Gastroenterology and Hepatology
"A six month randomized, placebo controlled, double blind pilot trial of 4 g/day curcumin in Alzheimer’s patients was found to be tolerated well." - Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease | Journal of Clinical Psychopharmacology
"3 mg per kg curcumin is generally regarded as a safe accepted daily intake in healthy humans." - Curcumin, an active component of turmeric (Curcuma longa), and its effects on health | Critical Reviews in Food Science and Nutrition
"Six months curcumin administration at a dose of 1.5 g/ day orally to type 2 diabetes mellitus patients was well tolerated." - Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus | Phytotherapy Research
"Regular oral intake of 1 g/day of curcumin for 3 months in osteoarthritic patients shows no sign of toxicity." - The efficacy of Curcuma longa extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial | Journal of the Medical Association of Thailand
"A good safety profile of curcumin was observed in patients with cardiovascular risk factors and patients affected by high risk conditions or pre-malignant lesions of internal organs taking a dose of curcumin ranging from 500 to 8000 mg/day for 3 months. This safety has been observed also in patients with advanced colorectal cancer, in breast cancer patients undergoing radiotherapy while taking up to 6000 mg/day of curcumin, and advanced pancreatic cancer patients taking 8000 mg/day of curcumin for 2 months." - Potential of Curcumin in Skin Disorders | Nutrients