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"Curcumin is not toxic to humans up to 8,000 mg/day.
A Phase I clinical trial of curcumin is well tolerated, when
administered in patients with high risk conditions or
pre-malignant lesions of the bladder, skin, cervix, stomach, or
oral mucosa as a single daily oral dose ranging from 500,to 8000
mg/day for 3 months. "-
Phase I clinical trial of curcumin, a chemopreventive agent, in
patients with high-risk or pre-malignant lesions | Anticancer
Research
" Curcumin has a
long established safety record. For example, according to JECFA
(The Joint United Nations and World Health Organization Expert
Committee on Food Additives) and EFSA (European Food Safety
Authority) reports, the Allowable Daily Intake (ADI) value of
curcumin is 0–3 mg/kg body weight. Several trials on healthy
subjects have supported the safety and efficacy of curcumin." - Curcumin, an active component of turmeric (Curcuma longa), and
its effects on health | Critical Reviews in Food Science
and Nutrition
"Curcumin has been one of the most studied herbal remedies,
attracting strong pharmaceutical attention due to its diverse
biological activities. Curcumin is one of the most studied
phytochemicals used as anticancer molecules. This polyphenol has
been used in traditional medicine in Asia since ancient times
and it has been shown to have extensive cytotoxic effects
against cancer cells. In addition, curcumin has also shown
beneficial and protective functions in acute myocardial
infarction and cardiovascular diseases, chronic atherosclerosis,
neurodegenerative diseases and autoimmune diseases. Interest in
curcumin has gradually increased after several studies
demonstrated its chemotherapeutic and chemopreventive effects."
-
International Journal of Molecular Sciences | 2023
"Curcumin is the most important chemical component of
turmeric, which can exert antioxidant, anti-inflammatory,
anti-angiogenic and anti-tumor pharmacological effects without
significant adverse effects. Studies have shown that curcumin
and curcuminoids in turmeric could provide good protection
against many chronic diseases in the body by inhibiting
inflammatory responses, lowering blood lipids, and improving
blood sugar. Curcumin in turmeric can effectively inhibit
inflammatory reactions and reduce symptoms such as pain and
swelling. In recent years, it was found that curcumin could
alleviate some symptoms in some autoimmune diseases such as
rheumatoid arthritis and inflammatory bowel disease" -
Frontiers in Immunology | 2023
"For thousands of years, turmeric has been used to treat
common colds, fevers, stomachaches, liver diseases, open wounds,
skin diseases, and chronic inflammations. After epidemiological
studies, turmeric may have the ability to lower cancer incidence
rates by 10-50% among those who regularly consume the spice.
Considered pharmacologically safe, curcumin possesses various
effects, including antioxidant, anti-inflammatory, and
anti-septic properties, and also modifies its influence on the
expression of genes involved in cytotoxicity, angiogenesis,
metastasis, and drug resistance. Curcumin mediates its promising
activities by regulating several key molecular targets." -
International Journal of Biological Sciences | 2023
"Curcumin is characterized by many desirable properties. It
has anti-inflammatory, antioxidant, and anticancer properties,
among others. Furthermore, importantly, it is safe and rarely
causes adverse symptoms. For this reason, it is used to treat or
support the treatment of many diseases, e.g., cardiovascular
diseases, inflammatory bowel diseases, breast, stomach,
pancreatic and lung tumors, dermatoses, allergic asthma, and
liver diseases." -
International Journal of Environmental Research and Public
Health | 2023
"According to the results of preclinical and clinical studies
conducted in vitro and in vivo, curcumin may be helpful in the
prevention and treatment of many diseases, including
cardiovascular diseases, diabetes mellitus, obesity, allergy,
asthma, inflammatory diseases, and neurodegenerative disorders,
e.g., Alzheimer’s, Parkinson’s, multiple sclerosis, and
Huntington’s disease by affecting different molecular targets.
Over the few current decades, considerable studies have been
conducted on curcumin due to its beneficial health properties,
including potent antioxidant properties, antimicrobial,
anti-inflammation, anticancer effects, cardio-protectiveness,
and hypoglycemic action. Compared to other medications, curcumin
is viewed as a very cost-effective and safe natural substance
that can be used to prevent and treat many disorders." -
Impacts of turmeric and its principal bioactive curcumin on
human health: A comprehensive review | 2023
"Research suggests that curcumin can help in the management of
oxidative and inflammatory conditions, metabolic syndrome,
arthritis, anxiety,,and hyperlipidemia. It may also help in the
management of exercise-induced inflammation and muscle soreness,
thus enhancing recovery and subsequent performance in active
people. In addition, a relatively low dose can provide health
benefits for people that do not have diagnosed health
conditions." -
Department of Nutrition, Central Michigan University | 2023
"Curcumin has been approved as a food additive by the World
Health Organization and the US Food and Drug Administration and
has been listed as a third-generation cancer chemoprevention
drug by the National Cancer Institute of the United States due
to its safety, non-toxicity, and lack of adverse effects." -
Curcumin
Targeting Non-Coding RNAs in Colorectal Cancer: Therapeutic and
Biomarker Implications, Biomolecules | 2022
"Curcumin may not fit medical chemists’ definition of the
perfect drug, but many in vitro, in vivo and clinical
trials have irrefutably confirmed its medicinal potential.
Curcumin, as a natural product with low price, has received
increasing attention in recent years. Many studies have
indicated that it has multiple biological activities." -
Frontiers in Pharmacology | 2022
"Curcumin has
been selected as a third-generation cancer chemopreventive agent
by the National Cancer Institute" -
Effects and Mechanisms of Curcumin for the Prevention and
Management of Cancers: An Updated Review | 2022
"One of the most commonly used herbal supplements is
curcumin, which has been extensively studied in cancer
prevention and treatment. In fact, a plethora of preclinical
studies have demonstrated the anti-cancer properties of curcumin
as well as its role as a chemosensitizer agent." -
International Journal of Molecular Sciences | 2022
"Curcumin, the key bioactive phytochemical present in
turmeric (Curcuma longa L.), is the most studied
natural compound in cancer. Preclinical studies (in vitro
and in vitro) and clinical trials have demonstrated
curcumin's effectiveness as an anti-inflammatory agent. The
existing evidence supports that curcumin inhibits the
proliferation of many types of cancer cells related to the
effect on different types of cancers, such as chronic myeloid
leukemia, multiple myeloma, prostate, colorectal and pancreatic
cancer as well as cancer therapy-related complications,
including oral mucositis and radiation dermatitis." -
The golden
spice curcumin in cancer: A perspective on finalized clinical
trials during the last 10 years, Journal of Cancer Research and
Therapeutics | 2022
"Curcumin, the active
ingredient of Curcuma longa L., is the most studied
compound described as a potential anticancer agent due to its
multi-targeted signaling/molecular pathways." -
Frontiers in Pharmacology | 2022
"The
most extensively studied plant material is
turmeric, Curcuma longa, which is the chief source of
curcumin. Based on the findings, it can be said that curcumin, a
natural substance, has good therapeutic qualities when it is
isolated." -
Applied Biochemistry and Biotechnology | 2022
"Curcumin, a multi-targeted compound, has traditionally been
used as a dietary spice and a medicinal herb in Asian countries
for a variety of pathologies due to its anti-inflammatory
properties, and antioxidant properties. Moreover, curcumin
possesses antibacterial, antiviral, antifungal, anti-arthritic,
hepatoprotective, anti-thrombotic, cardio-protective,
hypoglycemic, anti-allergic, wound-healing, and chemo-preventive
and anticancer properties. Curcumin’s anti-inflammatory and
antioxidant effects, among others, form the basis of curcumin’s
critical neuroprotective effects in a variety of neurological
diseases affecting both the central and peripheral nervous
systems. Several molecular targets of curcumin have been
identified based on extensive evidence from in vitro and in vivo
studies." -
Neuroprotective Activities of Curcumin in Parkinson’s Disease: A
Review of the Literature | 2021
"During the last decade, pharmacokinetics, pharmacodynamics and pharmacological
properties of curcumin, a yellow-orange polyphenolic compound, have been
extensively studied. Significant antitumor, antioxidant, antiviral,
lipid-lowering, chemopreventive, hepatoprotective and neuroprotective properties
of curcumin have been confirmed. Recent studies have also confirmed the
pharmacological activity of curcumin as anti-inflammatory and immunomodulatory
agent. Due to its pronounced anti-inflammatory activity, curcumin is
considered to be a potential mediator of accelerating the healing process." -
Curcumin: Natural Antimicrobial and Anti Inflammatory Agent, Journal of
Pharmaceutical Research International | 2021
"We found 12,595
papers on curcumin and 4738 on curcumin
and cancer; that means 37% of the published papers on curcumin has cancer as the
major targeted disease. The therapeutic
benefits of curcumin have been demonstrated in multiple chronic diseases:
inflammation, arthritis, metabolic syndrome, liver disease, obesity,
neurodegenerative diseases and, above all, in several cancers." -
Nutrients Journal
"Most studies have
classified curcumin as a non-toxic and safe material with a safe
dose for human clinical trials greater than 120 mg/m2" -
Pharmacological properties and underlying mechanisms of curcumin
and prospects in medicinal potential | Biomedicine &
Pharmacotherapy
"Curcuminoids have been approved by
the US Food and Drug Administration (FDA) as “Generally
Recognized As Safe” (GRAS), and good tolerability and safety
profiles have been shown by clinical trials, even at doses
between 4000 and 8000 mg/day and of doses up to 12,000 mg/day of
95% concentration of three curcuminoids: curcumin,
bisdemethoxycurcumin, and demethoxycurcumin." -
Curcumin: A Review of Its’ Effects on Human Health "A
phase 1 human trial with 25 subjects using up to 8000 mg of
curcumin per day for 3 months found no toxicity from curcumin.
Five other human trials using 1125-2500 mg of curcumin per day
have also found it to be safe."
-
The Journal of Alternative and Complementary Medicine
"Patients
received 8 grams curcumin by mouth daily, no toxicities were observed. Phase II
trial demonstrates that 8 g/day curcumin for 2 months is well
tolerated and exhibits biological effects in patients with
advanced pancreatic cancer. " -
Phase II
trial of curcumin in patients with advanced pancreatic cancer |
Clinical Cancer Research
"Oral
curcumin 6 g/day for 4–7 weeks during radiotherapy reduced the
severity of radiation dermatitis without any toxicity in breast
cancer patients." -
Curcumin for radiation
dermatitis: a randomized, double-blind, placebo-controlled
clinical trial of thirty breast cancer patients | Radiation
Research
"Studies
on human did not show toxic effects, and curcumin was safe at
the dose of 6 g/day orally for 4-7 weeks. Curcumin is known as a
generally recognized as safe substance. Turmeric and curcumin
are nontoxic for human especially in oral administration. Based
on the numerous experimental and clinical evidences, curcumin is
well tolerated in humans without significant side effects."
-
Turmeric (Curcuma longa) and its major constituent (curcumin)
as nontoxic and safe substances | Phytotherapy Research
"3.6
g/day oral curcumin for 6 months was well tolerated and safe in
leucoplakia patients demonstrating significant clinical
response." -
A Randomized Double-Blind
Placebo-Controlled Phase IIB Trial of Curcumin in Oral
Leukoplakia | Cancer Prevention Research
"Phase I
trials reported that curcumin extract in doses between 440 and
2200 mg/day for up to 4 months was well tolerated and is devoid
of dose limiting toxicity in patients with advanced colorectal
cancer, substantiating the safety of curcumin." -
Pharmacodynamic and pharmacokinetic study of oral Curcuma
extract in patients with colorectal cancer | Clinical Cancer
Research
"Therapy using 8000
mg
oral curcumin daily was safe and feasible in patients with pancreatic
cancer."
-
A phase I/II study of
gemcitabine-based chemotherapy plus curcumin for patients with
gemcitabine-resistant pancreatic cancer | Cancer Chemotherapy and Pharmacology
"Curcumin at a dose of 2 g/day for 6 months as oral maintenance
therapy proved to be safe in patients with ulcerative colitis."
-
Curcumin maintenance therapy for ulcerative colitis:
randomized, multicenter, double-blind, placebo-controlled trial
| Clinical Gastroenterology and Hepatology
"A
six month randomized, placebo controlled, double blind pilot
trial of 4 g/day curcumin in Alzheimer’s patients was found to
be tolerated well." -
Six-month randomized,
placebo-controlled, double-blind, pilot clinical trial of
curcumin in patients with Alzheimer disease | Journal of
Clinical Psychopharmacology
"3 mg per kg
curcumin is generally regarded as a safe accepted daily intake
in healthy humans." -
Curcumin, an active component
of turmeric (Curcuma longa), and its effects on health |
Critical Reviews in Food Science and Nutrition
"Six
months curcumin administration at a dose of 1.5 g/ day orally to
type 2 diabetes mellitus patients was well tolerated."
-
Evaluation of the effect of curcumin capsules on glyburide
therapy in patients with type-2 diabetes mellitus | Phytotherapy
Research "Regular
oral intake of 1 g/day of curcumin for 3 months in
osteoarthritic patients shows no sign of toxicity." -
The efficacy of Curcuma longa extract as an adjuvant therapy
in primary knee osteoarthritis: a randomized control trial |
Journal of the Medical Association of Thailand
"A good
safety profile of curcumin was observed in patients with
cardiovascular risk factors and patients affected by high risk
conditions or pre-malignant lesions of internal organs taking a
dose of curcumin ranging from 500 to 8000 mg/day for 3 months.
This safety has been observed also in patients with advanced
colorectal cancer, in breast cancer patients undergoing
radiotherapy while taking up to 6000 mg/day of curcumin, and
advanced pancreatic cancer patients taking 8000 mg/day of
curcumin for 2 months." -
Potential of Curcumin
in Skin Disorders | Nutrients
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