What is Turmeric and Curcumin?
Turmeric is a member of the Curcuma botanical group, which is part of the ginger family of herbs, the Zingiberaceae. The root and rhizome stem of the Curcuma longa plant is crushed and powdered into ground Turmeric spice. Ground Turmeric is used worldwide as a seasoning and is the source of extracted Curcumin.

"One of the greatest beneficial medicinal plants in the entire world...one of the most researched medicinal plants in history.” - Chris Kilham. Curcumin is a natural component of the rhizome of Turmeric and one of the most studied phytochemicals in science. Turmeric contains approximately 3% Curcumin, which is extracted until it is 95% pure to be researched or supplemented.


  What are the researched properties of Curcumin? 

"Over 7,000 studies confirm turmeric’s health-protective effects." - Natural News, 2017

"As of January 2015, there are nearly 5,000 studies and articles on Curcumin or Turmeric listed in the National Institutes of Health PubMed database." - Fox News

"More than 7000 published articles have shed light on the various aspects of curcumin including its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer activities." - Food and Chemical Toxicology

"PubMed.com, a research database maintained by the National Institutes of Health, lists 7,728 studies involving curcumin and another 3,205 studies involving turmeric, with the large majority focused on their effectiveness against multiple medical conditions." - Post Gazette

"Curcumin alone has been subject to more than 1,000 studies in 2014." - Natural Products Insider

"More than 6.000 articles published within the past two decades have discussed the molecular basis for the antioxidant, anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer activities assigned to this nutraceutical.- MD Anderson Cancer Center

"Curcumin has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. - Cancer Research and Treatment

"Over 100 clinical trials on curcumin in various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer." - Cytokine Research Laboratory, The University of Texas

"Extensive research over the past 30 years has shown that Curcumin plays an important role in the prevention and treatment of various pro-inflammatory chronic diseases including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and malignant diseases." - Cancer Research and Treatment

"Curcumin is the most widely-studied plant-derived medicinal chemical in modern science...based on a statistical analysis of over three million published scientific studies, Curcumin is the most frequently mentioned phytonutrient." - NaturalNews.com

"The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive." - Science News Magazine

  Where can I purchase Curcumin?
Order direct from Turmeric-Curcumin.com, the largest supplier of Turmeric Curcumin supplements at wholesale prices to the general public, research institutions, physicians, and university medical centers since 2000. Quality control tests, laboratory analysis certification, and rigorous cGMP manufacturing standards all ensure freshness, potency, and purity of content material. Orders are shipped FedEx or USPS Priority for fast and secure delivery. Contact support@turmeric-curcumin.com for bulk ordering, private labeling or any other questions. Multiple bottle orders will receive quantity discounts listed below, 12-bottle case purchases will also receive free US shipping.


   500 mG OF Curcumin 95% extract per capsule.

When selecting a Curcumin extract product, consumers should know the difference between Curcumin and Turmeric: Turmeric contains only 3% Curcumin on average. Consumers may be misled by deceptive marketing to believe there is a higher Curcumin percentage than there really is, examples include:

"Doctors Curcumin" on the front of the label, but checking the ingredient finds that each capsule is 100% Turmeric (curcuma longa), an inexpensive spice found in supermarkets and grocery stores.

"500mg Enhanced Formula!" only contains 200mg Curcumin extract, and the remainder is 300mg Turmeric spice.

"1000mg Super Complex Curcumin (25%)" which is actually only 250mg of Curcumin extract and the remaining 750mg is Turmeric spice.

"1000mg per serving", except the serving size is 4 capsules, 250 mg each.

"Curcumin with Turmeric 1500mg" but the serving size is 2 capsules, each with only 150mg Curcumin while the rest of the capsule is filled with 600mg of Turmeric spice.

Unfortunatley these deceptions are not uncommon in the supplement industry. The solution is to compare labels. Our label clearly indicates the contents - Curcumin extracted from Turmeric root - the purity - 95% concentration - and the amount per each capsule - 500mg.  The source of our Curcumin extract is Turmeric grown in India, never China. Within India, we are extensively networked with selected farms in the Eastern Ghat highlands, known for Turmeric with the highest natural Curcumin content in the world, at 8.8%. From this high quality Turmeric (Curcuma longa) root, we extract Curcumin to a minimum 95% concentration. Within this extraction is the full spectrum of curcuminoids - Curcumin (C), Demethoxycurcumin (DMC), Bisdemethoxycurcumin (BDMC) -  in their natural composition ratio of 76:19:5 for maximum potency. This is the same extract used in clinical trials and medical studies, free of added chemicals, treatments, or "patented formulas". There is no claimed "enhancing" material to fill the capsule and lower the Curcumin percentage. Our product contains no starch, no sugars or sweeteners, no artificial colors or flavors, no sodium, no soy, no yeast, no wheat, no corn, no rice or other grains, no gluten, no dairy, no preservatives, no GMO, no dyes, no gums, and no black pepper extract, piperine, or "bioperine" which is actually a trademark of the Sabinsa corporation.


  200 capsules per bottle.

Each bottle contains 200 capsules, and every 12-bottle case contains over two and a half pounds of Curcumin extract. The suggested serving size is one (1) to four (4) capsules with each meal, preferably with beneficial oils and fats, to offset the inflammatory response during ingestion and digestion.


  Are there side effects of Curcumin or Turmeric?

The safety, tolerability, and nontoxicity of curcumin at high doses are well established by human clinical trials. The US FDA classifies Turmeric as GRAS (Generally Recognized As Safe). Pregnant women, individuals with gallstones or using blood thinners should consult a health care provider before using herbs or dietary supplements in amounts greater than usually found in foods.

"Curcumin, even in large quantities, does not produce any known side effects in humans."

"Curcumin is not toxic to humans up to 8,000 mg/day."- Anticancer Research

"Patients received 8 g curcumin by mouth daily...No toxicities were observed." - Clinical Cancer Research

"A phase 1 human trial with 25 subjects using up to 8000 mg of curcumin per day for 3 months found no toxicity from curcumin. Five other human trials using 1125-2500 mg of curcumin per day have also found it to be safe." - Journal of Alternative and Complementary Medicine

"Therapy using 8 g oral curcumin daily was safe and feasible in patients with pancreatic cancer."


  Has the absorption of Curcumin 95% been studied?

In most studies Curcumin 95% has been delivered orally whether the subject is human or animals. This orally delivered Curcumin 95% extract showed antioxidant, anti-inflammatory, antidiabetic, and anticancer beneficial effects.

"Orally administered curcumin inhibited inflammatory cytokines such as TNF, cyclooxygenase (COX)-2, inducible nitric oxide synthase in mice indicating its anti-inflammatory activity and further suppressing dextran sodium sulfate-induced colon carcinogenesis." - Biofactors

"Clinical trials have shown that orally delivered curcumin inhibited inflammatory molecules." - AAPS Journal

  Has the bioavailability of Curcumin 95% been studied?
"In a human clinical trial, 3.6 g of Curcumin via oral route was found to produce a plasma curcumin level of 11.1 nmol/L after an hour of dosing." - Clin Cancer Research.

"The average peak serum concentrations after taking 4,000 mg, 6,000 mg and 8,000 mg of curcumin were 0.51 microM, 0.63 microM and 1.77 microM, respectively." - Phase I Clinical Trial of Curcumin, Anticancer Research

"Traces of curcumin were detected in the plasma. Its concentration in the small intestinal mucosa, between 39 and 240 nmol/g of tissue, reflects differences in dietary concentration...The comparison of dose, resulting curcumin levels in the intestinal tract, and chemopreventive potency suggests tentatively that a daily dose of 1.6 g of curcumin is required for efficacy in humans." - Journal Cancer Epidemiol Biomarkers.

"The concentrations of curcumin in normal and malignant colorectal tissue of patients receiving 3,600 mg of curcumin were 12.7 +/- 5.7 and 7.7 +/- 1.8 nmol/g, respectively...The results suggest that a daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut." - Cancer Epidemiol Biomarkers Prev.

  Are there any natural Methods of INCREASing bioavailability?
"Buttermilk could be used as a carrier for curcuminoids especially if delivered with food...The most important and practical finding from the bioaccessibility data is that the incorporation of powdered curcuminoids with buttermilk results in a 15-fold increase in bioaccessibility of curcuminoids." - Food Chemistry

  What are the pharmacological actions of Curcumin?

"Extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric (Curcuma longa), can modulate multiple cell signaling pathways. Extensive clinical trials over the past quarter century have addressed the pharmacokinetics, safety, and efficacy of this nutraceutical against numerous diseases in humans. Some promising effects have been observed in patients with various pro-inflammatory diseases including cancer, cardiovascular disease, arthritis, uveitis, ulcerative proctitis, Crohn’s disease, ulcerative colitis, irritable bowel disease, tropical pancreatitis, peptic ulcer, gastric ulcer, idiopathic orbital inflammatory pseudotumor, oral lichen planus, gastric inflammation, vitiligo, psoriasis, acute coronary syndrome, atherosclerosis, diabetes, diabetic nephropathy, diabetic microangiopathy, lupus nephritis, renal conditions, acquired immunodeficiency syndrome, β-thalassemia, biliary dyskinesia, Dejerine-Sottas disease, cholecystitis, and chronic bacterial prostatitis. Curcumin has also shown protection against hepatic conditions, chronic arsenic exposure, and alcohol intoxication. Dose-escalating studies have indicated the safety of curcumin at doses as high as 12 g/day over 3 months. Extensive preclinical studies over the past three decades have indicated curcumin’s therapeutic potential against a wide range of human diseases (). In addition, curcumin has been shown to directly interact with numerous signaling molecules (). These preclinical studies have formed a solid basis for evaluating curcumin’s efficacy in clinical trials. As of July 2012, observations from almost 67 clinical trials have been published, whereas another 35 clinical trials are in progress. The clinical trials conducted thus far have indicated the therapeutic potential of curcumin against a wide range of human diseases." - Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials
  How may Curcumin work against Alzheimer's disease and cognitive decline?

Common brain disorders, including depression and Alzheimer’s disease, have been linked to diminished levels of an important neurologic growth hormone called brain-derived neurotrophic factor. An Australian study, in the Journal of Psychopharmacology in 2015, found that curcumin improved attention and working memory and reduced mental fatigue in older people who took it for four weeks, compared to a placebo. Several studies have shown that curcumin, the active medicinal compound in turmeric, can increase levels of BDNF in the human brain and therefore delay or even reverse a range of common neurological disorders. In addition, scientists are beginning to suspect that the neurologic powers of curcumin don’t just stop there, with research suggesting that this compound may improve memory and increase cognitive capacity. Curcumin, thanks to its wide range of effects, seems to help the brain resist buildup of harmful plaque in brains with Alzheimer's.  A study in the Annals of Indian Academy of Neurology explored curcumin's potential for use in the treatment for Alzheimer's disease. Some of the key points included: Curcumin may help the macrophages, which play an important role in our immune system, clear the amyloid plaques found in Alzheimer's disease. Curcumin has anti-proliferative actions on microglia. Microglia are immune cells of the central nervous system that become active in response to any number of stressors on the body. However, if the microglia have been stimulated to react too often, they become hyper-reactive, which can trigger system-wide inflammation that can be difficult to stop. Curcumin has powerful antioxidant and anti-inflammatory properties. "Overall, curcumin decreases the main chemical for inflammation and the transcription of inflammatory cytokines … The exposure to curcumin also impaired the production of pro-inflammatory cytokines (IL-1, IL-6 and TNF-)." As chronic neuro-inflammation is considered one of the major factors in the development of Alzheimer's, it's possible too that curcumin may help in the treatment of other inflammatory disorders.Researchers found that Curcumin not only reduces oxidative damage and inflammation, but also reduces amyloid accumulation and synaptic marker loss and promotes amyloid phagocytosis and clearance. Curcumin worked to prevent synaptic marker and cognitive deficits caused by amyloid peptide infusion and abeta oligomer toxicity in vitro, and may help the immune system clear the brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Clinical trials are in progress at UCLA with Curcumin for Alzheimer's. In the Alzheimer’s Disease Anti-Inflammatory Prevention Trial, researched showed that reducing inflammation has positive effects on patients with Alzheimer’s. Curcumin significantly lowered several inflammation markers, in addition to reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent. "Worldwide, there are over 1000 published animal and human studies, both in vivo and in vitro in which the effects of curcumin on various diseases have been examined. Studies include epidemiological, basic and clinical research on AD." - Acad Neurol. 2008 Jan-Mar; 11(1): 13–19. The effect of curcumin (turmeric) on Alzheimer's disease: An overview Neuroprotective activity has also been shown in curcumin. In Alzheimer’s disease (AD), a peptide called β-amyloid (Aβ peptide) aggregates into oligomers and fibrils and forms deposits known as amyloid (or senile) plaques outside neurons in the hippocampus and cerebral cortex of patients. Another feature of AD is the accumulation of intracellular neurofibrillary tangles formed by phosphorylated Tau protein. Abnormal microglial activation, oxidative stress, and neuronal death are also associated with the progression of the disease. Curcumin has been found to inhibit Aβ fibril formation and extension and to destabilize preformed fibrils in vitro (51-53). Metal chelation by curcumin might interfere with metal ion (Cu2+/Zn2+)-induced Aβ aggregation. Curcumin might also affect the trafficking of Aβ peptide precursor (APP) and the generation of Aβ peptides from APP. Abnormally activated microglia and hypertrophic astrocytes around amyloid plaques in AD brains release cytotoxic molecules, such as proinflammatory cytokines and ROS, which enhance Aβ formation and deposition and further damage neurons. Curcumin was found to reduce the inflammatory response triggered by Aβ peptide-induced microglial activation and increase neuronal cell survival. When injected into the carotid artery of a transgenic mouse model of AD, curcumin was found to cross the blood-brain barrier, bind to amyloid plaques, and block the formation of Aβ oligomers and fibrils. In other animal models of AD, dietary curcumin decreased biomarkers of inflammation and oxidative damage, increased Aβ peptide clearance by macrophages, dismantled amyloid plaques in the brain, stimulated neuronal cell growth in the hippocampus, and improved Aβ-induced memory deficits. As a result of promising findings in animal models. a few recent clinical trials have examined the effect of oral curcumin supplementation on cognition in healthy older adults and AD patients. A randomized, double-blind, placebo-controlled trial in 60 healthy older adults (mean age, 68.5 years) investigated whether acute (80 mg) or chronic (80 mg/day for 4 weeks) oral intake of curcumin could improve their ability to cope with the mental stress and change in mood usually associated with undergoing a battery of cognitive tests A significant reduction in mental fatigue and higher levels of calmness and contentedness following cognitive test sessions were observed in individuals who consumed curcumin (either acutely or chronically) compared to the placebo group. Additionally, the results of cognitive ability tests suggested that curcumin treatment had limited benefits on cognitive function, as shown by better scores in measures of sustained attention and working memory compared to placebo. The results of a six-month trial in 27 patients with AD found that oral supplementation with up to 4 g/day of curcumin - containing all three major curcuminoids - was safe.
  How may Curcumin work against diabetes?

Curcumin has been shown to equal in effectiveness to the drug metformin in the management of diabetes, but without negative side effects. In the study curcumin was shown to lower blood glucose levels and reverse insulin resistance by suppressing glucose production in the liver. Among those verging on type 2 diabetes, curcumin capsules seem to help stall the onset of the disease. The study that returned these results found that while a little more than 16% of people taking a placebo wound up with a diabetes diagnosis, no one taking curcumin received one. A clinical trial from Thailand, published in Diabetes Care in 2012, found that people with prediabetes who took curcumin for nine months had improved function of insulin-producing cells in the pancreas, along with a significantly reduced risk of developing type 2 diabetes. Other studies suggest that curcumin can improve insulin sensitivity. Another study found curcumin improved metabolic function and reduced the risk of plaque buildup in the arteries of type-2 diabetes patients. Curcumin also acts as an anti-diabetic and antioxidant in patients with type-1 diabetes. Curcumin acts directly on liver cells to help prevent them from becoming fatty, and studies have concluded that Curcumin may have an anti-diabetic effect by decreasing serum fatty acid through the promotion of fatty acid oxidation and utilization. Curcumin also works directly on pancreatic beta cells to help them produce insulin normally. By helping the liver and the pancreas, Curcumin is taking stress off the two most important organs whose function declines before the onset of type 2 diabetes. Curcumin also influences key hormones, supports major body organs, and regulates inflammatory signaling all in ways that help correct or prevent metabolic problems. Curcumin helps lower inappropriately high levels of leptin (reducing leptin resistance) while boosting the all-important levels of the adiponectin (which lowers insulin resistance). Curcumin also helps activate the fat-burning gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat cells. Curcumin directly reduces major inflammatory events from occurring inside white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte chemotactic protein-1). By lowering such inflammation, the source of overweight-induced disease is targeted. Oxidative stress and inflammation have been implicated in the pathogenesis of type 2 diabetes mellitus and related vascular complications. A large body of preclinical evidence suggests that the antioxidant, anti-inflammatory, and glucose-lowering activities of curcumin and its analogs may be useful in the prevention and/or treatment of type 2 diabetes. In a nine-month, randomized, double-blind, placebo-controlled study in 237 subjects with impaired glucose tolerance (pre-diabetes), no progression to overt diabetes was reported with a daily ingestion of a mixture of curcuminoids (0.5 g), while 16.4% of placebo-treated participants developed diabetes. In addition, curcumin supplementation was shown to reduce insulin resistance and improve measures of pancreatic β-cell function and glucose tolerance. Supplemental curcumin was found to be as effective as lipid-lowering drug atorvastatin (10 mg/day) in reducing circulating markers of oxidative stress (malondialdehyde) and inflammation (endothelin-1, TNFα, IL-6) and in improving endothelial function. Another randomized controlled trial also reported that oral curcumin supplementation (1.5 g/day) for six months improved endothelial function, insulin sensitivity, and metabolic markers associated with atherogenesis (plasma triglycerides, visceral fat, total body fat) in participants with type 2 diabetes. Finally, in a two-month randomized, double-blind, placebo-controlled study in 40 individuals with type 2 diabetic nephropathy (kidney disease), daily curcumin ingestion (66.3 mg) significantly reduced urinary concentrations of proteins and inflammation markers (TGF-β, IL-8), suggesting that curcumin might be helpful with slowing the progression of kidney damage and preventing kidney failure.
  How may Curcumin work against CANCER?

Over the years, cancer research has examined the role curcumin plays in treating this disease. A number of laboratory studies on cancer cells have shown that curcumin does have anticancer effects. These studies have found that curcumin can significantly inhibit the growth, development and movement of cancer throughout the body. It seems to be able to kill cancer cells and prevent more from growing. It has the best effects on breast cancer, bowel cancer, stomach cancer and skin cancer cells. A 2007 American study that combined curcumin with chemotherapy to treat bowel cancer cells in a laboratory showed that the combined treatment killed more cancer cells than the chemotherapy alone. A 2007 American study in mice seemed to show that curcumin helped to stop the spread of breast cancer cells to other parts of the body. Doctors think that curcumin stays in the digestive system and is absorbed by the cells in the bowel. Several studies have shown that curcumin taken as capsules does get absorbed by the gut and is present in the blood.  One of the mechanisms by which it does this is reducing the growth of new blood vessels in tumors (otherwise known as angiogenesis) and can also directly contribute to the death of cancerous cells. Scientists discovered that turmeric is effective in killing cancer cells and also preventing their growth. According to the American Cancer Society, tests indicate that curcumin "interferes with several important molecular pathways involved in cancer development, growth and spread" and has boosted the effects of chemotherapy in animals. Curcumin has the potential for treatment of cancers including colon, breast, prostate, lung, skin and bowel. Curcumin shows a strong ability to kill cancer cells as well as inhibit their growth, boost antioxidant levels and balance the immune system. It seems to work on improving mitochondrial function at a cellular level. Even against drug-resistant strains of leukemia, curcumin caused cell death of cancer cells. Curcumin has been shown to substitute chemotheraphy for colorectal cancers, and in miltidrug resistant cancers. The ability of curcumin to regulate a variety of signaling pathways involved in cell growth, apoptosis, invasion, metastasis, and angiogenesis in preclinical studies elicited scientific interest in its potential as an anticancer agent in tumor therapy. Curcumin is one of the most powerful and promising chemopreventive and anticancer agents, and epidemiological evidence demonstrates that people who incorporate high doses of this spice in their diets have a lower incidence of cancer. Curcumin's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic investigators around the world. Because of low toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology testing and has successively made it through the first stages (Phase I) of clinical testing abroad and is currently in clinical trials at several sites in the U.S. A phase I clinical trial looked at giving curcumin to 25 patients with pre cancerous changes in different organs. This study seemed to show that curcumin could stop the precancerous changes becoming cancer. Numerous mechanisms have been described for the anticancer activity of Curcumin. Researchers at M.D. Anderson Cancer Center in Houston, TX state that Curcumin has “enormous” potential to prevent and treat cancer. Curcumin was able to suppress tumor formation, growth, and even metastasis according to their review. Currently, there are clinical trials being conducted on the effects of Curcumin on patients with bowel cancer. According to the American Cancer Society, tests have shown that curcumin can kill cancer cells in laboratory dishes, and also slow the growth of the surviving cells. Furthermore, it has been found to reduce the development of several forms of cancer in lab animals, while also shrinking various animal tumors. A 2003 review - Anticancer Potential of Curcumin: Preclinical and Clinical Studies - in Anticancer Research concluded that, "…it is quite apparent that curcumin has tremendous potential for prevention and therapy of various cancers." Another study on the role of curcumin in cancer therapy found that, "Research over the last few decades has shown that curcumin is a potent anti-inflammatory agent with strong therapeutic potential against a variety of cancers. Curcumin has been shown to suppress transformation, proliferation and metastasis of tumors," and called for additional and larger controlled studies to determine its full potential. Inhibition of proliferation of tumor cells, induction of apoptosis (a mode of cell death), inhibition of transformation of cells from normal to tumor, inhibition of invasion and metastasis and suppression of inflammation have been linked with the activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules, inflammatory cytokines, chemokines, growth factor receptors, vascular endothelial growth factor (VEGF) and transcription factors by Curcumin have been linked to its antitumor activity. An American phase 2 study reported in 2008. 25 patients had curcumin treatment and 21 had tumours that could be measured. In 2 patients their tumours shrank or remained stable. In some patients their levels of particular immune system chemicals that destroy cancer cells went up. Curcumin also has been studied with regards to the core inflammatory gene signal, NF-kappaB,resulting in a beneficial domino effect throughout the body. One benefit of this domino effect is a direct reduction in the risk of cancer from overweight-induced inflammation. ollowing DNA damage, the cell cycle can be transiently arrested to allow for DNA repair or for activation of pathways leading to programmed cell death (apoptosis) if the damage is irreparable. Defective cell-cycle regulation may result in the propagation of mutations that contribute to the development of cancer. Unlike normal cells, cancer cells proliferate rapidly and are unable to respond to cell death signals that initiate apoptosis. Curcumin has been found to induce cell-cycle arrest and apoptosis by regulating a variety of cell-signaling pathways (3, 41-45). For example, the inhibition of cell proliferation by curcumin has been associated with the Nrf2-dependent downregulation of DNA repair-specific flap endonuclease 1 (Fen1) in breast cancer cells in culture. Curcumin has been shown to induce p53-dependent or -independent apoptosis depending on the cancer cell type. In a panel of cancer cell lines, p53-independent apoptosis induced by curcumin was mediated by the rapid increase of ROS and the activation of MAPK and c-jun kinase (JNK) signaling cascades. Inhibition of NF-κB signaling by curcumin also suppresses proliferation and induces apoptosis in cancer cells. Inhibition of tumor invasion and angiogenesis Malignant and aggressive forms of cancer can invade surrounding tissues and spread to distant tissues once cancer cells have acquired the ability to leave the primary site (reduced cell-to-cell adhesion and loss of polarity), migrate, and disseminate. Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells acquire the ability to migrate and invade through downregulating proteins like E-cadherin and γ-catenin and expressing mesenchymal markers like MMPs, N-cadherin, and vimentin. In breast cancer cells, curcumin prevented EMT-associated morphological changes induced by lipopolysaccharide (LPS) while upregulating E-cadherin and downregulating vimentin. It was further shown that curcumin inhibited NF-κB/Snail signaling involved in LPS-induced EMT. In another study, curcumin increased the expression of the small non-coding RNA miR181b, which then downregulated proinflammatory cytokines, CXCL1 and CXCL2, as well as MMPs, thereby reducing the metastatic potential of breast cancer cells. Curcumin inhibited IL-6-induced proliferation, migration, and invasiveness of human small cell lung cancer (SCLC) cells by reducing JAK/STAT3 phosphorylation (i.e., activation) and downstream genes coding for cyclin B1, survivin, Bcl-XL, MMPs, intercellular adhesion molecule 1 (ICAM-1), and vascular endothelial growth factor (VEGF). Curcumin was found to exert its anticancer activities in many different types of cancer cells by regulating a variety of signaling pathways. Combining curcumin with anticancer drugs like gemcitabine in pancreatic cancer, docetaxel in breast cancer, and imatinib in chronic myeloid leukemia may be safe and well tolerated. A recent single-arm, phase II trial combining three cycles of docetaxel/prednisone and curcumin (6 g/day) was carried out in 26 patients with castration-resistant prostate cancer. The level of prostate-specific antigen (PSA) was decreased in most patients and was normalized in 36% of them, and the co-administration of curcumin with drugs showed no toxicity beyond adverse effects already related to docetaxel monotherapy. Many registered phase I/II clinical trials designed to investigate the effectiveness of curcumin alone or with first-line treatment in patients with breast, prostate, pancreatic, lung, or colorectal cancer are under way. Research into preventing cancer: A phase I clinical trial looked at giving curcumin to 25 patients with pre cancerous changes in different organs. This study showed how curcumin could stop the precancerous changes becoming cancer. A number of laboratory studies on cancer cells have shown that curcumin does have anticancer effects. It kills cancer cells and prevent more from growing. It has the best effects on breast cancer, bowel cancer, stomach cancer and skin cancer cells. A 2007 American study that combined curcumin with chemotherapy to treat bowel cancer cells in a laboratory showed that the combined treatment killed more cancer cells than the chemotherapy alone. A 2007 American study in mice showed that curcumin helped to stop the spread of breast cancer cells to other parts of the body. Doctors think that curcumin stays in the digestive system and is absorbed by the cells in the bowel. Several studies have shown that curcumin taken as capsules does get absorbed by the gut and is present in the blood.A number of activities of curcumin, which are exerted in a chemopreventive and a directly therapeutic manner, indicate that it may be a potential anticancer remedy. Although the results have been obtained in animal models, curcumin has been demonstrated to be active in various other in vitro models, and the dosages are comparable to those used in humans. In vitro and in vivo studies have indicated that curcumin prevents carcinogenesis by affecting two primary processes: angiogenesis and tumor growth. Turmeric and curcuminoids influence tumor angiogenesis through multiple, interdependent processes (2): i) Action at the level of transcription factors associated with inflammatory processes and early growth response protein which reduces the expression of IL­8 in pancreatic and head and neck cancer cell lines and prevents the induction of VEGF synthesis; ii) inhibition of angiogenesis mediated by NO (nitric oxide) and iii) inhibition of COX­2 and 5­LOX; iv) action at the level of angiogenic factors: VEGF, the primary factor for migration, sprouting, survival and proliferation during angiogenesis, and basic fibroblast growth factor. Curcumin induces cell death in numerous animal and human cell lines, including leukemia, melanoma, and carcinomas of the breast, lung, colon, kidney, ovaries and liver. It appears to function by caspase­dependent and independent (mitochondrial) mechanisms, which are associated with the presence and absence of p53. Androgen­dependent LNCaP prostate cancer cells were injected subcutaneously into mice fed with a 2% curcumin containing diet for up to 6 weeks (11). Curcumin significantly increased the extent of apoptosis, as measured by an in situ cell death assay, and caused a reduction in cell proliferation, as measured by a BrdU incorporation assay. Curcumin alone induced a 49–55% reduction in mean ovarian cancer tumor growth compared with control animals, while the combination of curcumin with docetaxel resulted in a 77% reduction in mean tumor growth compared with the controls. In an animal study, the administration of curcumin decreased the number of lung tumor nodules and inhibited lung metastasis of melanoma. Therefore, it is possible to use curcumin in order to arrest the metastatic growth of tumor cells.
  How may Curcumin work against arthritis?
Arthritis is a pro-inflammatory disorder. A recent study out of Japan evaluated its relationship with the inflammatory cytokine known to be involved in in the rheumatoid arthritis process. Scientists discovered that curcumin “significantly reduced” these inflammatory markers. In fact its anti-inflammatory qualities are so strong a 2007 study compared curcumin and cortisone and found they were equal in potency. A few studies have found that curcumin can reduce pain from rheumatoid arthritis or osteoarthritis, sometimes as much as anti-inflammatory drugs. An Iranian clinical trial in Phytotherapy Research in 2014 found that curcumin taken for six weeks, improved symptoms of knee osteoarthritis, compared to a placebo. Most pharmaceutical anti-inflammatories are contraindicated to use over the long-term, but turmeric is not only safe but beneficial for your overall wellbeing. Curcumin's anti-inflammatory properties also make it a strong candidate for treating inflammatory diseases such as osteoarthritis. A 2014 study in the Clinical Interventions in Aging found that curcumin extracts "were as effective as ibuprofen for the treatment of knee osteoarthritis." All current drugs approved for arthritis have anti-inflammatory activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production, block the action of TNF, and have activity against arthritis. When inflammation is reduced, the added benefit is pain relief. A double-blind, crossover study showed that Curcumin may be  effective in relieving pain and improvements in morning stiffness, walking time, and joint swelling. A preliminary intervention trial that compared curcumin with a nonsteroidal anti-inflammatory drug (NSAID) in 18 patients with rheumatoid arthritis (RA) found that improvements in morning stiffness, walking time, and joint swelling after two weeks of curcumin supplementation (1.2 g/day) were comparable to those experienced after two weeks of phenylbutazone (NSAID) therapy (300 mg/day). In a more recent randomized, open-label study in 45 RA patients, supplementation with a mixture of all three major curcuminoids (0.5 g/day for eight weeks) was found to be as effective as diclofenac (NSAID; 50 mg/day) in reducing measures of disease activity, tenderness, and swelling joints.
  How may Curcumin work against Crohn's disease and Ulcerative Colitis?
Crohn’s disease is a pro-inflammatory disease. All current drugs approved for this disease have anti-inflammatory activity. Anti-TNF therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production and the TNF action. Several clinical trials suggest that curcumin can help people with this inflammatory bowel disease. Clinical Gastroenterology and Hepatology featured a study in 2015 which found that in people with mild to moderate ulcerative colitis who took standard medication (mesalamine), the addition of a high-dose curcumin supplement helped half of them achieve remission after four weeks; none of those given a placebo benefited. Curcumin taken orally has been shown to have activity against inflammatory bowel disease. Study results suggest that Curcumin could have a protective role in ulcerative colitis via regulation of oxidant/anti-oxidant balance and modulation of the release of some inflammatory endocoids, namely TNF-alpha and NO. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial.  The development of DSS-induced colitis was significantly attenuated by curcumin. Inhibition of p38 MAPK signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and the nitrite production in colonic mucosa, reducing the development of chronic experimental colitis. In addition, Curcumin seems promising with regards to remission in patients with quiescent Ulcerative Colitis. Preliminary evidence suggests that curcumin might be useful as an add-on therapy to control disease activity. One multicenter, randomized, double-blind, placebo-controlled study has examined the efficacy of curcumin enema (2 g/day) in the prevention of relapse in 82 patients with quiescent UC . Six-month treatment with curcumin significantly reduced measures of disease activity and severity and resulted in a lower relapse rate than with placebo in subjects on standard-of-care medication (sulfasalazine or mesalamine). In another randomized controlled trial in active UC patients treated with mesalamine, the percentage of patients in clinical remission was significantly higher after a one-month treatment with oral curcumin (3 g/day) than with placebo. Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial.
  How may Curcumin work against obesity AND metabolic syndrome?
Obesity is Inflammatory Disease. "Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans. PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself." In the prevention and treatment of obesity and metabolic syndrome, Curcumin has been reported to modulate numerous targets that have been linked to obesity and insulin resistance. 1) Curcumin has been shown to downregulate the expression of TNF in various tissues. 2) Curcumin can suppress NF-κB activation induced by a wide variety of inflammatory agents through inhibition of degradation of IκBα. 3) Curcumin can inhibit the activation of IKK linked to the activation of NF-κB, and this leads to the suppression of expression of inflammatory biomarkers such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor. 4) Curcumin has been shown to downregulate the expression of various NF-κB-regulated proinflammatory adipocytokines including chemokines (such as MCP-1, MCP-4, and eotaxin) (199) and interleukins (IL-1, IL-6, and IL-8). Curcumin also suppressed the expression of plasminogen activator inhibitor type-1 through the inhibition of the transcription factor early growth response (Egr)-1 gene product that has been closely linked with insulin resistance and obesity. 5) Curcumin has been reported to mimic most antidiabetic drugs in that it activates PPAR-γ in hepatic stellate cells. 6) Curcumin has been shown to downregulate activation of c-Jun NH2 terminal kinase. 7) Curcumin has been shown to inhibit the Wnt/β-catenin pathway, which is closely linked to obesity. Later studies have indicated that Curcumin inhibits Wnt pathway signaling through downregulation of the transcription coactivator p300. Another potential mechanism by which Curcumin could inhibit β-catenin signaling is through inhibition of glycogen synthase kinase (GSK)-3β, which directly causes the phosphorylation of β-catenin. Curcumin was found to inhibit GSK-3β with as little as 66 nM IC50 (32). 8) Curcumin has been shown to induce the expression of hemeoxygenase (HO)-1 through the activation of Nrf2 in pancreatic cells and thus mediate the survival of these cells. 9) Curcumin downregulates the secretion of insulin-like growth factor-1 but induces the expression of insulin-like growth factor binding protein-3. 10) Curcumin interrupts leptin signaling by reducing phosphorylation levels of the leptin receptor (Ob-R) and its downstream targets. 11) Curcumin suppresses gene expression of Ob-R in HSCs. 12) Curcumin has been reported to increase the expression of adiponectin, which negatively controls obesity.
  How may Curcumin work against psoriasis?
Psoriasis is another pro-inflammatory disease. Considerable evidence, both in animals and humans, indicates that Curcumin may be effective against psoriasis. Curcumin protects skin by quenching free radicals and reducing inflammation. Unlike many antioxidants, Curcumin is capable of both preventing free radical formation, as well as neutralizing existing free radicals, and is considered an effective bioprotectant due to this dual activity. Curcumin is known for neutralizing free radicals, chemicals that damage healthy cells and membranes. That's what makes it a powerful antioxidant. It was also found to reduce wound-healing time, increase collagen growth and increase blood flow to the skin. This study on curcumin and skin found it is highly beneficial for scleroderma, psoriasis and skin cancer.
  How may Curcumin work against depression and major depressive disorder?
The core issue of depression has finally been identified as inflammation, and curcumin has been found to be comparable to prescription antidepressant drugs. In one 2014 study published in Phytotherapy Research, scientists studied 60 patients with serious depression over a six-week trial and found that turmeric was as effective at treating depression as Prozac.  This randomized control trial took 60 volunteers diagnosed with major depressive disorder (MDD) and compared the effect of curcumin to fluoxetine (Prozac). Researchers discovered that the principal curcuminoid in turmeric is not only as effective as Prozac in managing depression, but it doesn’t carry with it all the dangerous side effects as anti-depressive drugs do. One-third of the participants in the study were given 20 mg of fluoxetine (which is sold under the prescription names Prozac and Sarafem), one-third were given 1,000 mg of curcumin (the active ingredient in turmeric), and one one-third were given a combination of both. “Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential antidepressant-like activity in animal studies,” the researchers wrote. “The objectives of this trial were to compare the efficacy and safety of curcumin with fluoxetine in patients with Major Depressive Disorder (MDD).” They concluded that curcumin was “well tolerated” by all the patients. All three groups showed approximately equal improvement in their depression, whether they were taking the turmeric, the antidepressant or a combination of both.“This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders. A new study, published online ahead of print in the Journal of Affective Disorders, finds that the spice curcumin, a derivative of turmeric, may be an effective treatment for depression. The study was a randomized, placebo-controlled trial (the gold standard methodology for medication studies). The researchers found that curcumin was better than a placebo treatment, and those with atypical depression were far more likely to improve.The use of curcumin appeared especially effective for those with atypical depression. Atypical depression, despite its name, is relatively common (around 40% of MDD cases). The “atypical” moniker refers to its particular features: excessive sleep, weight gain, mood improvement in response to positive events, heavy, immovable feelings in the limbs, and interpersonal rejection sensitivity. Atypical depression is considered to have a more chronic course, with worse outcomes overall, so the potential for a viable treatment with fewer side effects than current medications provides hope for an improved prognosis. Previous studies have shown evidence that curcumin could be an effective treatment for depression and found minimal side effects. This study adds to the literature by comparing several doses of curcumin as well as a curcumin/saffron combination treatment. A 2006 study published in Brain Research examined the effects of curcumin administration to laboratory rats after exposure to a chronic stress protocol. Researchers found that curcumin supplementation had a beneficial effect on reducing stress-related symptoms of depression. A 2008 study in Psychopharmacology showed curcumin increased serotonin production and had an antidepressant effect on laboratory mice exposed to several lab tests. In a six-week, randomized, single-blinded, placebo-controlled study in 60 MDD patients, supplemental curcumin (~880 mg/day of curcuminoids) alone yielded a similar response rate to the antidepressant, fluoxetine (a serotonin reuptake inhibitor [Prozac]; 20 mg/day) in terms of depressive symptoms. A 2009 review published in Scientific World Journal hypothesizes that curcumin from turmeric may provide benefits for depression by assisting with the regulation of brain neurotransmitters like dopamine and serotonin and inhibiting the monoamine oxidase enzyme, which plays a role in breaking down these neurotransmitters.  The neurotransmitters are also what Prozac treats, helping serotonin be used effectively by the brain.  Major depressive disorder (MDD) is a neuropsychiatric disorder associated with abnormal neurotransmission; it is primarily treated with drugs that improve the bioavailability of neurotransmitters like serotonin, noradrenaline, and dopamine in the brain. Characteristics of MDD also include alterations in the hypothalamus-pituitary-adrenal axis, increased neuroinflammation, defective neurogenesis, and neuronal death. A few clinical studies have examined the effect of curcumin alone or with conventional antidepressant drugs in MDD patients. A recent meta-analysis of six randomized controlled trials found that supplementation with curcumin significantly reduced depression symptoms. Moreover, in a randomized controlled study in 100 participants taking escitalopram (a serotonin reuptake inhibitor [Lexapro]; 5 to 15 mg/week), supplemental curcumin (1,000 mg/day) for six weeks increased the antidepressant effect of the medication. Curcumin also induced a reduction in plasma concentrations of inflammatory markers and an increase in plasma concentrations of brain-derived neurotrophic factor compared to placebo (antidepressant drug alone).
  How may Curcumin work as an Anti-inflammatory?

Did evolution give us inflammatory disease? Researchers demonstrate that some variants in our genes that could put a person at risk for inflammatory diseases such as multiple sclerosis, Crohn's disease or rheumatoid arthritis, have been the target of natural selection over the course of human history. -  Science Daily Magazine. One 10-day “study of origin” suggests that a short period of return to the “conditions of existence” similar to those on which our genome is based may improve anthropometrics and metabolism by favorably challenging the immune system in apparently healthy subjects. The “return” may come with some costs in more active infection, as a trade-off for the “chronic systemic low-grade inflammation” typical of our current lifestyle of affluence. Chronic inflammation may be the engine that drives many of the most feared illnesses of middle and old age. This concept suggests a new and possibly much simpler way of warding off disease. Instead of different treatments for, say, heart disease, Alzheimer's and colon cancer, there might be a single, inflammation-reducing remedy that would prevent all three. This 'inflammation theory' explains how immune-system errors are linked to more illnesses. Medical researchers are becoming increasingly convinced that the most primitive part of the immune system (inflammation), may play a crucial role in some of the most devastating afflictions of modern humans, including heart disease, cancer, diabetes and possibly Alzheimer's. In another study, findings suggest that in the past, gene variants rose in frequency in the human population to help protect us against viruses, bacteria and other pathogens. But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely. These results are consistent with the hygiene hypothesis in which our cleaner environment is thought to contribute to the increasing prevalence of inflammatory diseases.  While short-term inflammation in the body is a necessary component of a functioning system, helping to fight off pathogenic invasion and repairing tissue and muscle damage, chronic inflammation is widely attributed with almost every disease known to the Western world. This includes heart disease, cancer and a whole host of neurological disorders. The high concentrations of curcumin contained in turmeric act to target multiple steps in the inflammatory pathway, blocking inflammatory markers at the molecular level and thereby significantly lowering long-term inflammation in your body. Whether we are healing from an injury or an autoimmune disease, inflammation is a common health challenge. Nutritionists, functional medicine GP’s and physiotherapists commonly use curcumin for it’s anti-inflammatory qualities. And it’s no wonder considering six major scientific trials all found curcumin to possess a potent anti-inflammatory action, which is completely non-toxic in nature. A study evaluating several pharmaceutical anti-inflammatories found that aspirin and ibuprofen are the least potent, while curcumin is among the most potent anti-inflammatory and anti-proliferative agents available. Inflammation is thought to be one of the major factors in all kinds of diseases, and turmeric contains loads of curcumin, a powerful anti-inflammatory substance. No word on whether it works on politicians' speeches (hah!). It's been shown to alleviate joint pain, and can even help with heartburn and indigestion. Researchers are also looking at curcumin for its anti-aging properties. Turmeric is safe and non-toxic and has been studied for anti-inflammatory properties, inhibiting various molecules that contribute to inflammation such as lipooxygenase, COX-2, leukotrienes, prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis factor (TNF), and interleukin-12 (IL-12).  One study compared the effectiveness of Curcumin – the active ingredient in turmeric – and a popular non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone. At the end of the six days, those taking the Curcumin and the NSAID enjoyed a significantly better anti-inflammatory response than placebo. The spice worked as well as the drug, but without the negative side effects. "Because of the crucial role of inflammation in most chronic diseases, the potential of Curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of Curcumin have been examined in animals and in humans." - Trends Pharmacol Sci. 2009 Feb;30(2):85-94. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Curcumin has also been shown to inhibit mediators of the inflammatory response, including cytokines, chemokines, adhesion molecules, growth factors, and enzymes like cyclooxygenase (COX), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). Nuclear factor-kappa B (NF-κB) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, and genes involved in cell proliferation, adhesion, survival, and differentiation. The anti-inflammatory effects of curcumin result from its ability to inhibit the NF-κB pathway, as well as other pro-inflammatory pathways like the mitogen-activated protein kinase (MAPK)- and the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT)-dependent signaling pathways. Inhibition of dextran sulfate sodium (DSS)-induced colitis by curcumin in mice has been associated with a downregulation of the expression of p38-MAPK and pro-inflammatory cytokine TNF-α and a reduction of myeloperoxidase (MPO) activity, a marker of neutrophil infiltration in intestinal mucosa. Curcumin has also been shown to improve colitis by preventing STAT3 activation and STAT3-dependent induction of cell proliferation in mouse colon. Moreover, curcumin was shown to attenuate the immune response triggered by collagen injections in a mouse model of rheumatoid arthritis, partly by blocking the proliferation of T lymphocytes in mouse splenocytes. In addition, curcumin has been found to reduce the secretion of TNF-α and IL-1β and the production of COX-2-induced prostaglandin G2. In one study, curcumin inhibited the secretion of matrix metalloproteins (MMPs) — responsible for the degradation of the synovial joints — in human fibroblast-like synoviocytes and in human articular chondrocytes. Curcumin has also been found to alleviate neuro-inflammation in a mouse model of traumatic brain injury, reducing macrophage and microglial activation and increasing neuronal survival. A placebo-controlled trial in 40 men who had surgery to repair an inguinal hernia or hydrocele found that oral curcumin supplementation (1.2 g/day) for five days was more effective than placebo in reducing post-surgical edema, tenderness and pain, and was comparable to phenylbutazone therapy (300 mg/day).
  How may Curcumin work against CARDIOVASCULAR HEART Disease?
 In a Japanese study in Nutrition Research in 2012, postmenopausal women who took curcumin for eight weeks had an improvement in arterial function, comparable to that seen in women who engaged in aerobic exercise. An Iranian study in Phytotherapy Research in 2013 found that curcumin reduced triglycerides, while a Taiwanese study in 2014 found that curcumin significantly reduced LDL (“bad”) cholesterol and triglycerides in people with metabolic syndrome. Curcumin also helps the endothelium (the lining of blood vessels) to function at its optimum level, similar to the effect found during intense exercise. Studies have shown that endothelial dysfunction is a common cause of heart disease, occurring when the endothelium is no longer able to regulate blood pressure, clotting and a number of other factors. Therefore, by improving endothelial function, curcumin lowers your risk of heart disease. In addition to helping out the endothelium, curcumin also reduces inflammation and oxidative damage, two factors that are also common contributors to heart disease.
  What are the scientific properties of Curcumin?
Chemical Name Diferuloylmethane
Definition A β-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups
Systemic Name (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)
Molecular Formula C21H20O
Molar mass 368.38 g/mol
Appearance Bright yellow-orange powder
Melting Point 183 °C, 361 °F
PubChem 969516
Biofunction Enzyme cofactor
Chemical Taxonomy Organic Chemicals / Hydrocarbons / Aromatic Compounds /  Phenols / Catechols / Curcuminoids
Chemical Structure
Organic Taxonomy Kingdom
Plantae (Plants) 
Tracheobionta (Vascular plants)
Spermatophyta  (Seed plants) 
Magnoliophyta  (Flowering plants)
Liliopsida  (Monocotyledons) 
Zingiberaceae  (Ginger family) 
Curcuma (Curcuma)
Curcuma longa  (Turmeric)

   Why Turmeric root extract Curcumin may provide health benefits?

Certain plants manufacture chemicals that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of organic compounds that deter attackers become more successful, because of their advanced protection. In nature's never-ending interaction between predator and prey, insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring this evolution between plants and insects represents an important field of ecological research. Scientists have discovered that many phytochemicals manufactured in plants and roots not only prevent insect attack or fight plant infections, but also provide human health benefits. Many cultures create their own botanical pharmacies as the lore of medicinal plants and remedies is handed down through generations of healers. With the advent of sophisticated laboratory testing, biologists are finding that the many indigenous plants and roots from around the world provide medicinal value, and their metabolites are candidates for research. Curcumin’s structure is similar to other natural polyphenolics (chemicals containing multiple "phenol" groups) produced by plants in response to infectious attack. These natural polyphenols often have potent anti-oxidant and anti-inflammatory properties as well as immune support health benefits. Curcumin from Turmeric, resveratrol from grapes, pterostilbene from blueberries, and catechins from green tea all contain polyphenolic antioxidants and have been studied for medicinal or preventive value. Every medicinal molecule in all of botany is made out of carbon dioxide. CO2 is the key source of carbon used by plants to synthesize everything from Cucumin to resveratrol. Every healing nutrient in basil, oregano, cinnamon, turmeric, garlic and pomegranate fruit is made out of carbon dioxide. Curcumin, a powerful anti-cancer nutrient found in turmeric, is made from carbon dioxide, with 21 carbon molecules manufactured from atmospheric carbon dioxide. Curcumin has been studied for anti-oxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities, mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered TNF blockers (humira, remicade and enbrel), vascular endothelial cell growth factor blocker (avastin), human epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib), and HER2 blocker (herceptin). Considering the recent scientific bandwagon that multi-targeted therapy is better than mono-targeted therapy for most diseases, Curcumin is a phytonutrient that can be considered an ideal "Spice for Life". More than 5000 papers published within the past two decades have revealed that Curcumin has extraordinary potential in promoting health through modulation of numerous molecular targets.


   What is the history of Curcumin and Turmeric?

Turmeric is an ancient spice and a traditional remedy. It has been used in food and as medicine for at least 4,000 years, first in India (Ayuverdic) and other parts of Asia, and later in Africa and the Caribbean. Researchers in India recently identified mineral remnants of turmeric and ginger on the cooking pots of ancient Indus River remains, one of the first urban civilizations.These ancient civilizations have vast trial and error experience with many different herbal remedies and food preparations and they selected Curcumin as a food additive and major tool for medicinal use based on efficacy. Numerous therapeutic activities have been assigned to Turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastro-intestinal systems, aches, pains, wounds  and disorders. Marco Polo, writing of his travels in China, described Turmeric in the 13th century: "There is also a vegetable which has all the properties of the true saffron, as well as the color, and yet it is not really saffron. Turmeric is held in great estimation, and being an ingredient in all their dishes, it bears, on that account, a high price."  The high degree of reverence for Turmeric is established by the fact that it is used in many cultures, each having its own name for the spice: Burmese: fa nwin. Chinese: wong geung fun, yüchiu. Danish: gurkemeje. Dutch: geelwortel. Finnish: keltajuuri. French: curcuma, saffron des Indes. German: gelbwurz, kurkuma. Icelandic: turmerik. Italian: curcuma tumeric Indian: haldee, haridra, haldi, huldee, huldie. Indonesian: kunjit, kunyit. Japanese: ukon circumin Malay: kunjit. Norwegian: gurkemeie, Polish: klacze kurkumy. Portuguese: açafrão-da-Índia. Russian: zholtymbir. Spanish: azafrán de la India, azafran arabe. Sinhalese: kaha. Swedish: gurkmeja. Tamil: munjal. Thai: ka min. Vietnamese: botnghe
  Why hasn't the pharmaceutical industry patented Curcumin?
Pharmaceutical corporations tried registering patents for Curcumin and Turmeric because of the much heralded scientific evidence and the long history of its healing properties. However, that same evidence and history of Curcumin being used medicinally for centuries was the reason the United States Patent and Trademark Office rejected and revoked the rights for Turmeric patent 5401504 on the grounds that the claims were not new: "USPTO unequivocally rejected all six claims made on August 13, 2001 ruling that Turmeric's medicinal properties were not patentable."  University of Texas MD Anderson Cancer Center states "in the case of Curcumin, a natural compound, no company can reap the benefits if Turmeric shows itself to be an effective anti-cancer drug."
  news and published studies on Curcumin and Turmeric

February  2018

The Surprising Health Benefit Hiding In Turmeric, The bright yellow spice may help protect your brain, a new study finds
Mens Health, February 2018
At the end of the study, the curcumin group experienced a 28 percent improvement in their memory tests, while those popping the placebo didn’t see a significant change. What’s more, they also saw a slight boost in their mood compared to the placebo poppers. The researchers can’t say exactly why curcumin might have these effects. But after analyzing the brain scans, they noticed that people taking curcumin had lower levels of both abnormal proteins, specifically in areas of the brain that influence memory and emotion. Plus, curcumin is an antioxidant that might fight inflammation, explains study author Gary W. Small, M.D., director of the UCLA Longevity Center. The more inflammation you have in your brain, the more likely you are to experience cognitive problems and depression, he says.

Curcumin May Reverse Memory Problems, Improve Mood
Forbes,  February 2018
With more and more of the aging population affected by Alzheimer's disease, and clinical trials for new medications often providing underwhelming results, a new study in The American Journal of Geriatric Psychiatry may be especially promising. It finds that taking a daily dose of curcumin, the compound in turmeric root that gives curry its yellow color, may not only prevent memory problems from worsening over time, but actually improve them. And perhaps most noteworthy, these changes were seen not only in the participants' cognitive capacities, but also in their brain cells. It turned out that the memory function of those who’d taken curcumin improved by 28% on average over the 18 months. In contrast, the control group's scores rose slightly (possibly because they got more familiar with the tests) and then declined. The depression scores of those taking curcumin also improved; the control group's didn't change. And interestingly, brain scans revealed significantly less amyloid and tau accumulation in two brain regions of the participants taking curcumin—the amygdala and hypothalamus, which control anxiety, memory, decision-making, and emotion.

Is Turmeric Beneficial to Everyone? Dr. David Samadi Explains.
Reporter Expert,  February 2018
Renowned surgeon David Samadi is enthusiastic about people using turmeric to improve their own health. Dr. Samadi is the chairman of urology and the chief of robotic surgery at New York City’s Lenox Hill Hospital. He is a world leader in using cutting-edge technology to treat cancer patients. At the same time, he is passionate about educating people about what they can do for themselves to live a healthy and vibrant life. To that end, he makes frequent appearances in the media to spread his knowledge to as many people as possible. Dr. Samadi is a member of the Medical A-Team on Fox News and is the chief medical correspondent on AM 970, a popular radio station serving the New York City metropolitan area. According to Dr. Samadi, turmeric may be helpful in treating or preventing arthritis, inflammatory bowel disease, Alzheimer’s disease, cancer and depression. He explains the science behind turmeric’s beneficial effects in treating the following common conditions: Arthritis Studies show that curcumin, the active ingredient in turmeric that has anti-inflammatory properties, can help relieve the pain caused by joint inflammation. Inflammatory Bowel Disease Studies show that curcumin lowers the rate of relapse for people suffering from ulcerative colitis, which is a chronic form of inflammatory bowel disease. Alzheimer’s Disease Research shows promising results in using turmeric to help slow down the progression of this terrible disease. Scientists believe that curcumin may help destroy the plaque that causes Alzheimer’s patients to lose cognitive function. Countries where turmeric is frequently used in cooking have lower rates of Alzheimer’s disease. Cancer Research shows that curcumin may help reduce the spread of tumors in patients who have pancreatic and some other types of cancer. It is not a stand-alone treatment, but it may be useful as a supplement to other forms of treatment. Depression Several studies have shown that curcumin can help reduce the symptoms of depression. How to Use Turmeric for Your Health If you are not used to cooking with turmeric, you may wonder how to incorporate it into your daily life. You can buy turmeric as a whole root or in dried and powdered form. Both are good, but the dried form has a higher concentration of curcumin, the component of turmeric most often studied for its anti-inflammatory health benefits. Dr. David Samadi points out that a standard dosage of turmeric hasn’t been established. However, he suggests that one to three grams per day of the dried form of turmeric is probably enough. How to Maximize the Absorption of Curcumin Dr. Samadi suggests that you consume turmeric when you are eating a meal. Taking turmeric with food helps your body better absorb the curcumin in the turmeric. You can help ensure you are absorbing the maximum amount by ingesting turmeric while you are eating a meal that contains healthy fats. These fats include fish oil, olive oil, avocado oil, coconut oil, nuts and seeds.

Turmeric Compound Boosts Cognitive Power, Reveals New Study
Sci-News,  February 2018
Curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance. “The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not,” Dr. Small said. “In memory tests, the people taking curcumin improved by 28% over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.”

Curcumin limits weight gain.
Journal of Applied Physiology,  February 2018
We investigated the effect of curcumin, a naturally occurring polyphenol known for its anti-inflammatory properties and inhibitory action on 11β-HSD1 activity, on preserving metabolic health and limiting adipose tissue growth following the cessation of daily exercise and caloric restriction (CR). Cessation of daily CR and exercise caused an increase in body mass, as well as a 9- to 14-fold increase in epididymal, perirenal, and inguinal adipose tissue mass, all of which were attenuated by curcumin ( P < 0.05). Insulin area under the curve (AUC) during an oral glucose tolerance test, HOMA-IR, and C-reactive protein (CRP) were elevated 6-, 9-, and 2-fold, respectively, in the Detrained + Placebo group vs. the Trained group (all P < 0.05). Curcumin reduced insulin AUC, HOMA-IR, and CRP vs. the placebo group (all P < 0.05). Our results indicate that curcumin has a protective effect against weight regain and impaired metabolic control following a successful period of weight loss through diet and exercise, perhaps via inhibition of glucocorticoid action and inflammation.

Lowering your risk of Alzheimer's disease
Express,  February 2018
Memory loss could also be prevented by eating more curry, scientists have claimed. The spice curcumin - which gives curry its bright colour - could boost patients' mood and memory. Eating curcumin everyday for 18 months improved memory by 28 per cent, a study claimed.

Natural supplements that you should be taking every day
Blasting News,  February 2018
Turmeric -- The spice that gives curry that yellow coloring. This powerful herb's main ingredient is curcumin, a natural anti-inflammatory which the body needs to fight off bacteria that are harmful. Along with the increased production of antioxidants and a great way to fight heart disease, another important benefit of taking Turmeric is the growth hormone called Brain-Derived Neurotrophic Factor. According to the US National Library of Medicine, decreased levels of BDNF can lead to brain disease and decreased functions in the brain. Curcumin can increase levels of BDNF, which can delay or even reverse many brain diseases or age-related decreases in brain function. You will want to add this to your supplement routine, as curcumin makes up only three percent of Turmeric, so taking it as a supplement is better.

Curcumin Improves Mood and Memory
Doctor Oz,  February 2018
UCLA researchers find consumption of curcumin helps mood and memory. Forty adults with mild memory complaints were randomly selected to ingest curcumin twice daily or a placebo for 18 months. They underwent cognitive assessments and PET scans to test amyloid in the brain, which is associated with negative effects on memory and emotional functions. Those taking curcumin improved their memory tests by twenty-eight percent, demonstrated mild mood improvements, and showed far smaller levels of amyloid than the placebo group. A follow-up study will explore the possibility of curcumin possessing antidepressant effects and whether it can help your genetic risk for Alzheimer’s. These findings back up the far lower rate of Alzheimer’s in India’s senior citizens, whose diet is high in curcumin.

Curry Ingredient May Improve Memory
GKMan,  February 2018
Participants who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not. Therefore it has been proven that curcumin can contribute to the improvement of memory and disposition of people suffering from moderate memory loss cause by aging. A new study has been published, confirming that curcumin, the chemical that gives curry its intense yellow color, has important health benefits, in the context of long-term consumption.

The healing power of turmeric: Curcumin may lower Alzheimer’s disease risk by boosting memory and mood
Times Now News,  February 2018
Earlier, a report published in the British Medical Journal Case Reports, noted that a 57-year-old woman, who was diagnosed with blood cancer in 2007 after complaining of high blood pressure, curcumin helped her recover from the deadly condition after conventional medicine failed to work on her body. The report said the woman started taking 8g of curcumin a day - one of the main compounds in turmeric - as a last resort after research online. With no further treatment, over the last five years, doctors said her cancer had remained stable and her blood counts are within the normal range with daily curcumin. The findings revealed that people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not. Turmeric is one of the most traditional and versatile of spices used in Indian cooking. It has been suggested as a possible reason that senior citizens in India have a lower prevalence of Alzheimer’s and better cognitive performance.

Curcumin's Anti-Inflammatory Properties Might Improve Memory, Attention
Ask Men,  February 2018
Turmeric is on a tear right now. In recent years it’s been connected to everything from healthier skin to helping control pain and inflammation. But new research suggests it can also aid with memory and happiness. The paper, published last week in the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed supplement of curcumin — the substance that gives turmeric its bright orange colour — on the performance of memory in people without dementia. The study also looked at curcumin’s potential impact on the microscopic plaques and tangles that occur in the brains of those with Alzheimer’s disease. The heavy use of turmeric in cooking has already been raised as a possible reason for the lower rates of Alzheimer’s disease and better cognitive performances among senior citizens in India compared to the rest of the world. Why? Most likely because of its capacity to reduce brain inflammation, “which has been linked to both Alzheimer’s disease and major depression,” said the study’s author, Doctor Gary Small of UCLA, in a news release. The study involved a double-blind, placebo-controlled group of 40 adults between ages 50 and 90. They were Alzheimer’s and dementia free, but all reported mild memory complaints. The participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months. They were then monitored at six month intervals throughout the test using a standardized cognitive assessment. After 18 months, those who had been taking curcumin were reporting significant improvements in memory and attention abilities. On average, their memory tests improved by a whopping 28%. The curcumin takers also reported a slight improvement in mood when compared to those on the placebo.

Striking with the Root: Turmeric Curcumin and Ulcerative Colitis
Care2,  February 2018
Despite evidence going back 40 years that the turmeric spice component curcumin possesses significant anti-inflammatory activity, it wasn’t until 2005 that it was first tested on inflammatory bowel disease. Why did it take so long? Well, who’s going to fund such a study? Big curry? Even without corporate backing, individual physicians from New York decided to ask the next five patients with ulcerative colitis who walked through their office doors to start curcumin supplements. And, researchers obliged. They took a bunch of people with quiescent ulcerative colitis and gave them either turmeric curcumin along with their typical anti-inflammatory drugs, or a placebo and their drugs. In the placebo group, 8 out of 39 patients relapsed, meaning their disease flared back up. In the curcumin group, however, only 2 out of 43 relapsed, significantly fewer. And, relapse or not, clinically, the placebo group got worse, while the curcumin group got better. Endoscopically, which is objectively visualizing the inside of their colons, doctors saw the same thing: a trend towards worse or better. The results were stunning: a 5 percent relapse rate in the curcumin group compared with a 20 percent relapse rate in the conventional care group. It was such a dramatic difference that the researchers wondered if it was some kind of fluke. Even though patients were randomized to each group, perhaps the curcumin group just ended up being much healthier through some chance coincidence, so maybe it was some freak occurrence rather than curcumin that accounted for the results. So, the researchers extended the study for another six months but put everyone on the placebo to ensure the initial findings were not some aberration. The curcumin was stopped to see if that group would then start relapsing, too—and that’s exactly what happened. Suddenly, they became just as bad as the original placebo group. The researchers concluded: “Curcumin seems to be a promising and safe medication for maintaining remission in patients with quiescent ulcerative colitis.” Indeed, no side effects were reported at all. So, “Curry for the cure?” asked an accompanying editorial in the journal of the Crohn’s and Colitis Foundation of America. “Can curcumin be added to our list of options with respect to maintaining remission in ulcerative colitis? What is noteworthy about this trial is the fact that not only did the authors demonstrate a statistically significant decrease in relapse at 6 months, but a statistically significant improvement in the endoscopic index as well. Equally telling is the fact that upon withdrawal of curcumin the relapse rate quickly paralleled that of patients treated initially with placebo, implying that curcumin was, in fact, exerting some important biologic effect.” Similarly, a Cochrane review concluded in 2013 that curcumin may be a safe and effective adjunct therapy.

Curcumin Shown to Improve Memory
Whole Foods Magazine,  February 2018
Results of the study are as follows: Memory function of those who’d taken curcumin improved by 28% on average over the 18 months. In contrast, the control group’s scores rose slightly (possibly because they got more familiar with the tests) and then declined. The depression scores of those taking curcumin also improved; the control group’s didn’t change. Brain scans revealed significantly less amyloid and tau accumulation in two brain regions of the participants taking curcumin — the amygdala and hypothalamus, which control anxiety, memory, decision-making, and emotion.

Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury
Molecules,  February 2018
Curcumin pre-treatment significantly decreased CCl4-induced inflammation. Furthermore, curcumin pre-treatment significantly down-regulated the expression of TGF-β1 and Smad3 mRNAs (both p < 0.01), and up-regulated the expression of nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p < 0.01) in the liver. Inhibition of HO-1 attenuated the protective effect of curcumin on CCl4-induced acute liver injury. Given these outcomes, curcumin could protect against CCl4-induced acute liver injury by inhibiting oxidative stress and inflammation, which may partly involve the activation of Nrf2/HO-1 and inhibition of TGF-β1/Smad3 pathways.

Curcumin ‘improves mood and memory
Health Spectator,  February 2018
Daily consumption of curcumin improves the memory and mood of people with mild, age-related memory loss, according to a new study by the University of California, Los Angeles. The research, which has been published the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed curcumin supplement on memory performance in people without dementia, as well as curcumin’s impact on the microscopic plaques and tangles in the brains of people with Alzheimer’s. Found in turmeric, curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s and better cognitive performance. The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not. In memory tests, the people taking curcumin improved by 28 per cent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.

How turmeric can help treat irritable bowel syndrome (IBS)
The Health Site,  February 2018
The active ingredient in the spice, curcumin, has a laundry list of health benefits. A recent case study in the BMJ showed how a cancer-stricken 57-year-old woman who was given only a few months to live cured herself with turmeric. Currently, there is enough evidence to make a case for turmeric as complementary therapy also for irritable bowel syndrome or IBS. The beneficial effects of turmeric on IBS could be attributed to its anti-inflammatory, antioxidant, antibacterial and spasmolytic effects. Another 2010 study conducted on animals showed that curcumin in the turmeric could be beneficial in curbing stomach disorders such as diarrhoea, cramps and IBS.

How a Nutritionist Uses Turmeric For Health
Pop Sugar,  February 2018
Research published in the journal Oncogene found that turmeric is actually a more effective anti-inflammatory than over-the-counter pain relievers like aspirin and ibuprofen. ADVERTISEMENT This is a modal window. The media could not be loaded, either because the server or network failed or because the format is not supported. Turmeric can also be used to increase levels of brain-derived neurotrophic factor (BDNF), which is a growth hormone in the brain that, when low, is responsible for increased risk of Alzheimer's disease, depression, and a host of other mental ailments. The curcumin in turmeric has also been proven to reverse symptoms of heart disease. Many other studies have found a parallel function and effect of the substance on your heart as compared to exercise.

Health benefits of turmeric
Philstar,  February 2018
Antidepressants. Curcumin the main substance in turmeric may be used as an effective and safe therapy for treatment in patients with mild depression. Arthritis management. Because curcumin is known for its powerful anti-inflammatory and pain-reducing characteristics, it has an amazing effects on people suffering from various types of arthritis. Cancer treatment. A number of laboratory studies on cancer cells have shown that curcumin does have anticancer effects. It seems to be able to kill cancer cells and prevent more from growing. It has the best effects on breast cancer, bowel cancer, stomach cancer, and skin cancer cells. Diabetes management. For lowering blood sugar and reversing insulin resistance, there’s arguably no better natural treatment than adding turmeric into your diet. Obesity. A study published in the journal “Biofactors” showed that curcumin can help promote weight loss. The researchers found that the anti- inflammatory properties in curcumin were effective at suppressing the inflammatory process of obesity, therefore helping to reduce obesity and its “adverse health effects.” Cholesterol regulators. One of the reasons heart disease is such a problem in the U.S. is that people are developing pre-diabetes (high blood sugar) at an alarming rate. A study done by “Drugs in R & D found that curcumin was equal, or more effective than diabetes medication at reducing oxidative stress and inflammation in the treatment of high cholesterol. Painkillers. One of the more widely accepted properties of curcumin in scientific communities is its ability to manage pain. Therapeutic use of turmeric and other curcumin-rich plants are displacing conventional medical treatments and proving it’s a legitimate natural pain killer.

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy
Medical Sciences,  February 2018
Curcumin (diferuloylmethane), the natural polyphenol responsible for the characteristic yellow pigment of the spice turmeric (Curcuma longa), is traditionally known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression of carcinogenesis through multiple mechanisms, curcumin has potential utility for both chemoprevention and chemotherapy. In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues. Numerous studies have demonstrated that pretreatment with curcumin can abrogate carcinogen-induced ODC activity and tumor development in rodent tumorigenesis models targeting various organs. This review summarizes the results of curcumin exposure with regard to the modulation of polyamine metabolism and discusses the potential utility of this natural compound in conjunction with the exploitation of dysregulated polyamine metabolism in chemopreventive and chemotherapeutic settings.

Supplements That Enhance Detoxification
Newsmax,  February 2018
Curcumin, quercetin, hesperidin, ellagic acid, naringenin and other flavonoids enhance phase II detoxification. They also protect liver cells and other tissues and organs. They are all powerful antioxidants and more versatile than the antioxidant vitamins.

Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer
Oncology Reports,  February 2018
Curcumin is known to exhibit anticancer effects on various cancers with selective cytotoxicity in tumor cells. Our results showed that curcumin inhibited the viability of A549 cells time‑ and dose‑dependently. In addition, a dosage-dependent A549 cell apoptosis‑induction phenomena was observed by the curcumin intervention. Moreover, obvious autophagy was induced after curcumin‑treatment, characterized by the formation of fluorescent particles [autophagic vesicles (AVs)] and significant increase in ratio of LC3‑Ⅱ/LC3‑Ⅰ and Beclin1 as well as decreased p62 expression. Furthermore, the effect of curcumin on a substantial downregulation of phosphatidylinositol 3‑kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was observed. It is worth noting that the inhibition of mTOR by rapamycin or of PI3K/Akt by LY294002 augmented curcumin‑induced apoptosis and autophagy, leading to significant inhibition of cell proliferation. From these findings, it can be speculated that curcumin potently inhibit the cell growth of NSCLC A549 cells through inducing both apoptosis and autophagy by inhibition of the PI3K/Akt/mTOR pathway. These results support the potential use of curcumin as a novel candidate in treatment of human lung cancer.

Diabetes and Obesity Linked to Higher Cancer Risk: 4 Foods That Reduce This Risk
NDTV,  February 2018
Turmeric: The principle component of turmeric is curcumin which is a potent antioxidant scavenging free radicals and inhibiting the growth of cancerous cells. Almost 2000 published scientific papers have shown that curcumin has the ability to kill cancer cells while not harming the healthy cells.

Curcumin Protects against Atherosclerosis
Journal of Agricultural and Food Chemistry,  February 2018
Curcumin supplementation significantly reduced TLR4 expression and macrophage infiltration in atherosclerotic plaques. Curcumin also reduced aortic interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-κB (NF-κB) activity, and plasma IL-1β, TNF-α, soluble VCAM-1 and ICAM-1 levels. In addition, aortic sinus sections revealed that curcumin treatment reduced the extent of atherosclerotic lesions and inhibited atherosclerosis development. In vitro, curcumin inhibited NF-κB activation in macrophages and reduced TLR4 expression induced by lipopolysaccharide. Our results indicate that curcumin protects against atherosclerosis at least partially by inhibiting TLR4 expression and its related inflammatory reaction.

Turmeric pills help woman survive blood cancer
Los Angeles Times, January 2018
In 2011, Ferguson decided to take daily supplements of curcumin, the beneficial compound in turmeric, every night. A couple of months after she began the regimen, she started on a weekly course of hyperbaric oxygen therapy. The non-traditional treatment involves breathing in pure oxygen from an enclosed chamber with specific atmospheric pressure adjustments. Since then, Ferguson's cancer has remained stable and her blood counts are within a safe and normal range. Of course, due to the close proximity of her introduction of turmeric and the hyperbaric oxygen therapy, it's uncertain whether it was the turmeric that cured the progression of her disease. "The fact that our patient, who had advanced stage disease and was effectively salvaged while exclusively on curcumin, suggests a potential antimyeloma effect," the report concludes. "We would recommend further evaluation of curcumin in myeloma patients in the context of a clinical trial."

British Woman Beats Rare Cancer With 2 Teaspoons Of This Per Day
The Alternative Daily, January 2018
Ferguson decided to try treating herself with a “golden spice” called curcumin, which is a naturally occurring chemical compound in the herb turmeric after she had heard about how another woman (named Margaret) had used it successfully to treat her myeloma. Ferguson began taking eight grams (about two teaspoons) of curcumin per day for about five years. As a result, she is now vastly improved to the point where her cancer count is considered both manageable and negligible. Jamie Cavenagh, professor of blood diseases at London’s Barts Hospital, who has subsequently co-authored a report on Ferguson’s case, believes curcumin was a decisive part of her amazing recovery. As Cavenagh explains, “When you review her chart, there’s no alternative explanation for her recovery other than we’re seeing a response to curcumin.” Dr. Abbas Zaidi, a hematologist at Barts NHS Health Trust, who contributed to the report on Ferguson, also believes that curcumin played an important role in her improvement.

Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”
Journal of Neuroinflammation, January 2018
Oral administration of curcumin restored the imbalance between the sympathetic and parasympathetic tones in CIA rats and increased ChAT activity and expression of ChAT and VAChT in the gut, brain, and synovium. Additionally, VGX eliminated the effects of curcumin on arthritis and ACh biosynthesis and transport. Electrophysiological data showed that curcumin markedly increased neuronal excitability of the vagus nerve. Furthermore, selective α7 nAChR antagonists abolished the effects of curcumin on CIA. Our results demonstrate that curcumin attenuates CIA through the “gut-brain axis” by modulating the function of the cholinergic system. These findings provide a novel approach for mechanistic studies of anti-arthritic compounds with low oral absorption and bioavailability.

Healing foods
Navhindtimes.in January 2018
Curcumin is a powerful antioxidant with powerful anti-inflammatory effects. Studies have shown that curcumin and turmeric have antimutagenic and anticancer properties and have also been shown to be effective against Alzheimer’s disease in animal models. A glass of hot milk with a pinch of haldi is a common household remedy for a cold and sore throat. Curcumin is fat soluble and needs to be absorbed in the presence of fat. Hence haldi should be fried along with the seasonings in oil. Black pepper has also been found to increase the absorption of cucurmin. Supplements containing haldi extracts or curcumin should be taken after a meal as the fat in the meal helps in its absorption.

The miracle of turmeric: How can this golden spice help reinvigorate your health
Express, January 2018
The 67-year-old, who had battled blood cancer for five years, began taking daily doses of curcumin, one of the main compounds of turmeric. More familiar as an ingredient in curries the spice is also an ancient remedy for a variety of ailments. While this natural approach won’t work for everyone the Londoner’s cancer-cell count is now negligible. As Dieneke’s doctors hail the remarkable results we take a look at turmeric and the ways in which it may boost health. The spice, recognisable by its golden colour, is ground from the dried root of a plant called Curcuma longa. A relative of ginger it thrives in warm, moist conditions and has long been used as a medicine in Chinese and Indian cultures. Turmeric’s healing powers are attributed to phytochemicals, compounds which are present in many plants. Curcumin, which is found in turmeric, is claimed to be one of the most powerful remedies in nature’s medicine cabinet. Another benefit of turmeric may be combating depression, stress and anxiety. It is claimed curcumin can be used as a natural alternative to drugs such as Prozac, working by inhibiting an enzyme in the brain that is responsible for depression. There may be a double whammy as it is claimed curcumin can also increase levels of serotonin and dopamine – chemicals that boost happiness. The powers of curcumin could even extend to improving the sex life of men by improving blood flow to the genitals.

Wonder curry spice could be used to treat cancer after stunning doctors
Leicester Mercury, January 2018
Ms Ferguson began taking 8 grams of curcumin - one of the main compounds in turmeric - each day in tablet form. It’s the equivalent of about two teaspoons. Her illness has an average survival of just over five years - making it one of the most fatal forms of the disease. It was rapidly spreading - causing increasing back pain - and she had already had a second relapse. Dr Abbas Zaidi, a haematologist at Barts NHS Health Trust, said: "Here we describe a myeloma patient who started a daily dietary supplement of curcumin when approaching her third relapse. "In the absence of further antimyeloma treatment the patient plateaued and has remained stable for the last five years with good quality of life." The remarkable improvement described in BMJ Case Reports follows previous research into the health benefits of turmeric which is packed with antioxidants.

Cancer patient, 67, ‘beats the disease with the help of TURMERIC’ after five years of chemo failed
The Sun, January 2018
In 2011 she began taking daily doses of curcumin, a key component of the spice turmeric, after another two rounds of stem cell therapy failed. Dieneke took eight grams of curcumin each night on an empty stomach. Dieneke took eight grams of turmeric every night and her blood cancer stabilised. Over the last five years her cancer has remained stable and her blood counts are within the normal range, doctors report. She has also maintained a good quality of life during this period, according to the report. Curcumin is a micronutrient derived from the herb turmeric, and has been used as a traditional Indian medicine for centuries.

Foods That Can Help You Prevent from Getting Cancer
Your Health Mag, January 2018
Curcumin, a major component of curry, contains curcumin, which blocks or reduces tumors.

Woman Halts Cancer in Its Tracks With Turmeric
Metro, January 2018
She took 8g of turmeric tablets every day for years without further treatment, and has now shocked doctors. ‘To the best of our knowledge, this is the first report in which curcumin has demonstrated an objective response in progressive disease in the absence of conventional treatment,’ her doctors, from Barts Health NHS Trust in London, wrote in the British Medical Journal Case Reports. ‘In the absence of further antimyeloma treatment the patient plateaued and has remained stable for the past five years with good quality of life.’ Turmeric is widely used in Asian cuisine and helps create distinctive colour in curries – but it would be impossible to cure myeloma with regular cooking turmeric. It would be impossible to treat cancer with regular kitchen turmeric, as it contains just 2% curcumin.

What is curcumin? Brit woman claims the wonder spice halted incurable blood cancer for a decade
International Business Times, January 2018
Dieneke Ferguson said she takes 8gram curcumin every day in a tablet form to fight the incurable myeloma. After all other treatments failed, North London resident Ferguson decided to fight back and began using curcumin — a component derived from a popular Indian spice turmeric. She said she has been taking 8gram of the compound every day in a tablet form and the result has been nothing less than a miracle. "I have been on all sorts of toxic drugs and the side-effects were terrifying. At one point I lost my memory for three days, and in 2008 two of the vertebrae in my spine collapsed so I couldn't walk," the cancer survivor said, as quoted by the Daily Mail. "They injected some kind of concrete into my spine to keep it stable." Her recovery has since baffled doctors who are yet to come to a conclusion on the effectiveness of curcumin. "Here we describe a myeloma patient who started a daily dietary supplement of curcumin when approaching her third relapse. In the absence of further antimyeloma treatment the patient plateaued and has remained stable for the last five years with good quality of life," Dr Abbas Zaidi, a haematologist at Barts NHS Health Trust said in a report, which mentions that her cancer cell count is currently negligible."Curcumin is a polyphenol derived from the perennial herb turmeric and has - for centuries - been used as a traditional Indian medicine," explains Zaidi in the case study. "The biological activity of curcumin is indeed remarkable." He added that the pigment produces multiple effects through its "natural antioxidant, anti-inflammatory, antiseptic and analgesic properties"

Curcumin targets gut-brain axis in reducing inflammation, study finds
Horsetalk, January 2018
The research team from the China Pharmaceutical University in Nanjing said many studies in recent years had shown that taking curcumin by mouth eased collagen-induced arthritis. A clinical trial, they noted, had shown that curcumin was safe and effective for patients with rheumatoid arthritis. However, studies had shown that its bioavailability was poor, which raised questions about how it produced its anti-inflammatory effect. They set out to explore whether the gut-brain axis was involved in its therapeutic action. The researchers found that curcumin did indeed reduce collagen-induced arthritis through the gut-brain axis by regulating the function of the cholinergic system.

Chemopreventive and Antitumor Efficacy of Curcumin in a Spontaneously Developing Hen Ovarian Cancer Model
Cancer Prevention Research, December 2017
Our results demonstrated for the first time that daily curcumin intake leads to a significant and dose-dependent reduction in spontaneous ovarian cancer incidence and tumor growth, indicating a tremendous role for curcumin as a chemopreventive strategy for ovarian cancer.

The Effect Of Curcumin On Plasma Metabolomic Profile In Atherogenic Diet Induced Rat Model Of Alzheimer’s Disease
Nutrition and Food Science, December 2017
Curcumin, a polyphenol extricated from the plant Curcuma longa, has demonstrated its remedial advantages in Alzheimer's ailment and was utilized as a positive control. Curcumin exhibited a potential therapeutic effect in high cholesterol diet induced AD.

Curcumin reverses tobacco smoke‑induced epithelial‑mesenchymal transition
Molecular Medicine Reports, December 2017
Tobacco smoke is a major risk factor for lung cancer. Epithelial‑mesenchymal transition (EMT) is decisive in cancer invasion and metastasis, and therefore promotes cancer progression. The chemopreventive effect of curcumin on carcinogenesis has been reported in vivo and in vitro. Curcumin treatment inhibited tobacco smoke‑induced MAPK/AP‑1 activation, including ERK1/2, JNK and p38 MAPK pathways, and AP‑1 proteins, and reversed EMT alterations in lung tissue. The results of the present study provide new insights into the molecular mechanisms of tobacco smoke‑associated lung cancer and may open up new avenues in the search for potential therapeutic targets in lung tumorigenesis.

Potent Remedies That Support the Liver
Care 2, December 2017
Turmeric is a potent spice with many health benefits. Recent studies show it can improve circulation, prevent cancer, reduce pain and detoxify the body. Thanks to curcumin, a bioactive compound found in turmeric, this herb helps the liver remove toxins and wastes from the body. It’s also worth mentioning that curcumin increases production of bile, and as a result improves liver function.

Exactly How Much Turmeric to Have a Day to Reap Its Anti-Inflammatory Benefits
Pop Sugar, December 2017
"Turmeric is recommended for many patients with inflammatory conditions such as Crohn's disease, ulcerative colitis, autoimmune conditions like psoriasis, rheumatoid arthritis, osteoarthritis, Parkinson's disease, Alzheimer's disease, dementia, and cancers. Curcumin is the compound found in turmeric," said Atlanta-based integrative medicine physician Dr. Bindiya Gandhi. Arguably, the most powerful aspect of curcumin is its ability to control inflammation. "The journal Oncogene published the results of a study that evaluated several anti-inflammatory compounds and found that aspirin and ibuprofen are least effective, while curcumin is among the most effective anti-inflammatory compounds in the world," said Dr. Josh Axe, DNM, CNS, DC, bestselling author of Eat Dirt. "This news should have reached every household in the world after the study was conducted, because inflammation puts people at risk for almost every disease process known to man," he said. You can find turmeric in powder culinary spice form and in its whole root form, as well as in tincture, tablets, and capsules. "A good starting dose for its anti-inflammatory benefits is 400 to 600 mg of standardised powder or curcumin turmeric extract three times a day as tolerated," Dr. Gandhi said.

Curcumin: common dietary supplement turned anti-cancer compound?
Oxford University Press, December 2017
Over the past few decades, curcumin, a common food additive, has been identified as a potential anti-inflmmatory and anti-cancer compound. Curcumin is a phenolic compound extracted from the Curcuma longa plant, and was traditionally used as a spice for improving flavor and color into dishes of various Asian countries. Curcumin’s health benefits are not a new or surprising finding — the brightly colored compound has been used in Ayurvedic medicine for centuries for its potent anti-inflammatory and anti-tumor properties — but the fundamental mechanisms underlying its anti-cancer potential still remain an active area of interrogation. Intriguingly, curcumin has been shown to sensitize multiple cancers to chemotherapy drugs, and several recent studies have reported that curcumin is able to specifically target cancer stem cells. . As suggested by other groups, not only did we demonstrate that curcumin was able to enhance the sensitivity of gemcitabine in these resistant cells, we found that curcumin was also able to inhibit the growth of cancer stem cells. In our study, we also discovered that curcumin was regulating a class of non-coding RNA called “long non-coding RNAs” (lncRNAs). LncRNA is a relatively newly discovered type of non-coding RNA — RNA which does not make protein — found to be dysregulated in most cancers. We discovered that curcumin inhibits the expression of one of the most well-known lncRNA-based oncogenes, a gene that drives cancer, called PVT1. This lncRNA drives tumor progression through the regulation of another well-recognized oncogene, called EZH2. EZH2 is one of the oncogenes known to be involved in drug resistance and is identified to be a potential drug-able target. Though the generation of specific EZH2 inhibitors remains challenging, the findings from our study indicate that curcumin could be used to inhibit the expression of EZH2, as well as the non-coding RNA that regulates EZH2. Considering that curcumin is a commonly available health supplement, it presents itself as a non-toxic compound and incredibly cost-effective compound for the potential treatment of cancer patients.

Curcumin improves diabetes mellitus‑associated cerebral infarction by increasing the expression of GLUT1 and GLUT3
Molecular Medicine Reports, December 2017
Curcumin is characterized by anti‑inflammatory, anti‑oxidative, antiviral, antifibrotic, anticoagulation and glucose regulatory functions. Curcumin markedly decreased cell apoptosis, indicating an anti‑apoptotic role of curcumin in the brain. To further evaluate whether curcumin prevented cell apoptosis by modulating the expression of GLUT1 and GLUT3, small interfering RNAs targeting GLUT1 and GLUT3 were selected. It was found that the knockdown of GLUT1 and GLUT3 inhibited the abundance of GLUT1, GLUT3 and B‑cell lymphoma 2, even following incubation with curcumin. These data showed that curcumin protected brain cells from apoptosis and cerebral infarction, predominantly by upregulating GLUT1 and GLUT3.

Natural Remedies for Tendonitis
Care 2, December 2017
An extract of the spice turmeric, which is often used in curries to give them a yellowish color, curcumin is an excellent choice in dealing with any type of inflammation. While there are few studies on its use for tendonitis, preliminary research published in the Journal of Biological Chemistry showed that curcumin has a place in the healing of tendonitis.

Curcumin Enhances the Efficacy of 5-FU in Colo205 Cell Lines
Proceedings, December 2017
Curcumin was observed to increase the efficacy of 5-FU and accelerate the cytotoxic effect by removing the cytostatic period seen in the first 6 h. The study results show that the combination of 5-FU and curcumin in Colo205 can reduce the dose by increasing the cytotoxic activity of 5-FU and reducing the resistance to the anticancer drug.

Health benefits of the humble turmeric
Hindustan Times, December 2017
Turmeric is a root that is as popular as ginger in Ayurveda. Many of its beneficial aspects are due to its active compound, curcumin. Curcumin has a profoundly anti-inflammatory effect on the body, and provides a good defence system against diseases. Inflammation is the body’s reaction to toxic elements in our environment, such as water with heavy chlorine, air pollution, unhealthy oil (trans fats), stress, lack of sleep, and overuse of chemical aromas, deodorants, cleaning agents, etc.

Can Curcumin be Employed to Promote the Integration of Oncology and Natural Products?
Proceedings, December 2017
Curcumin inhibits NF-kB activation pathway at a step before inhibitor kappa B alfa (IKBα) phosphorylation. Preclinical in vivo and in vitro trials that combine curcumin with tyrosine kinase inhibitors (TKIs) have shown that this combination shows better results than each treatment alone. Retrospectively evaluated seventeen NF-kB overexpressed cancer patients were treated with i.v. and oral bioavailable formulation of curcumin and appropriate TKIs. TKIs decision was made according to genetic profiling (FoundationOne®). Toxicities and response was evaluated according to RECIST and common toxicities criteria. All patients are stage IV and heavily pretreated. Our longest experience comes from adenoid cystic carcinoma and he has treated for 72 months by oral curcumin and 8 months by i.v curcumin. Disease control rate was 89.3% (15/17) and no any grade III-IV toxicities was observed related to curcumin. Curcumin is multitargeted molecule with pleotrophic nature. Curcumin inhibits NF-κB and related proteins which promotes effectiveness of TKIs. And might be considered as long as we have to use chemotherapy, radiotherapy and TKI.

Which spice wins for its medicinal properties?
Daily Sabah Health, December 2017
What makes turmeric, which is quite rich in iron and manganese, a key ingredient in alternative medicine is its active ingredient curcumin. Curcumin is one of the best herbs for good health due to large amounts of vitamins C and E. Turmeric is a lightened version of curcumin that can be used in kitchens. Thanks to the curcumin in it, turmeric regulates sleep patterns. It also prevents muscles from getting tired very quickly and boosts sports performance. Some studies indicate that by using turmeric, symptoms can be decreased and inflammation-related conditions, including arthritis, can be eased. Moreover, scientists have proven that consuming turmeric helps to slow down the symptoms of Alzheimer's disease. However, the signature benefit of turmeric is in the treatment of inflammation.

Curcumin, quercetin and atorvastatin protected against the hepatic fibrosis by activating AMP-activated protein kinase
Journal of Functional Foods, December 2017
Curcumin, quercetin, and atorvastatin protected against the hepatic fibrosis by reducing hepatic fat accumulation via AMPK up-regulation.

Curcumin Beats Diabetes Drug at Lowering Blood Sugar: Study
News Max, December 2017
Natural remedies, however, can be very effective,” he adds. “A large number of studies have shown that curcumin can be very helpful at decreasing blood sugar as well as the complications of diabetes.” Other studies have shown its effectiveness in treating other aspects of diabetes, both in Type 1 and Type 2 according to the Website, Diabetes Self Management. David Spero, R.N., says that research conducted by Beijing University of Chinese Medicine and McGill University showed that curcumin reduced both blood sugar and cholesterol levels. Curcumin suppressed the activities of white blood cells called macrophages that cause inflammation as well as slowed down many of the complications of diabetes, in which inflammation plays a role. Curcumin improved insulin function by helping the hormone get into the cells thus reducing insulin resistance. In a study of 240 people in Thailand, curcumin prevented prediabetes from developing into full blown diabetes. Roughly 16 percent of the people studied in the placebo group progressed to Type 2 diabetes within 9 months while nobody in the group receiving 250 milligrams of curcuminoids from supplements progressed. Curcumin protects beta cells, which produce insulin. Studies have found that beta cells grew faster and lived longer in rats who consumed curcumin. In addition to its diabetes-fighting properties turmeric has been found to be an effective anti-inflammatory — even more effective than aspirin or ibuprofen and even Celebrex without the potentially deadly side effects of these drugs. As a cancer treatment, multiple studies have shown that curcumin holds promise in fighting against skin cancer, breast cancer, bowel and stomach cancers. A 2007 study found that curcumin combined with chemotherapy killed more cancer cells than chemotherapy alone. The American Cancer Society states that curcumin interferes with the development, growth, and spread of cancer cells. Curcumin has also been shown in multiple studies to be more effective than the popular drug Zoloft to beat depression,” adds Teitelbaum. “And if that’s not enough, current research suggests it may also decrease the risk of developing Alzheimer’s disease. The only side effect reported to my knowledge is that you start feeling fantastic.”

Studies that prove Curcumin can kill at least 3 types of cancer
emaxhealth, November 2017
Lung cancer: The effects of curcumin in chronic obstructive pulmonary disease (COPD) airway inflammation and lung cancer progression, were tested in an animal model study. Scientists administered to mice, the natural anti-inflammatory agent curcumin, 1% in diet before and during weekly non-typeable Hemophilus influenzae (NTHi ) exposure, which has been associated with the pathology of COPD. It was observed that curcumin significantly reduced the number of visible lung tumors in the absence of NTHi exposure by 85% and in the presence of NTHi exposures by 53%. It is important to note that Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions, and the effect of curcumin in decreasing the migratory and invasive ability of A549 ( lung carcinoma cells) cells by inhibiting adiponectin expression is probably mediated through NF-κB/MMP pathways. Ovarian carcinoma: In vitro and in vivo experiments of curcumin with and without docetaxel (chemotherapy medication) were done using human ovarian cancer cell lines. It was observed that Curcumin inhibited inducible NF-kappaB activation and suppressed proliferation in vitro. In vivo dose-finding experiments revealed that 500 mg/kg orally was the optimal dose needed to suppress NF-kappaB and signal transducers and activators of transcription 3 activation and decrease angiogenic cytokine expression. Colorectal cancer::Cyclo-oxygenase 2 (COX2), which mediates prostaglandin synthesis during inflammation, and which is selectively overexpressed in colon tumours, is thought to play an important role in colon carcinogenesis. But, a study that tested Human colon epithelial cells (HCEC) and SW480 colon carcinoma against curcumin, concluded that curcumin inhibits COX2 induction by the colon tumour promoters, tumour necrosis factor alpha or fecapentaene-12, which are fecal mutagens that are naturally produced in the human colon and have a role in neoplastic transformation of the colon. It is important to note that curcumin, not only affects signaling of proteins like tumor necrosis factor-(TNF) or the nuclear factor NF-κB. Curcumin also blocks interleukin-1 (IL-1) signalling, which as previously mentioned has been associated with the pathology of different types cancer. Therefore, the powerful ability to interfere in the mechanisms involved in cancer, make curcumin a natural cancer killer.

Drastically Reduce Your Colon Cancer Risk
Care2.com, November 2017
Curcumin, one of the phytonutrients found in the spice turmeric, has been found in numerous studies to reduce colon cancer risk. A study found in Cancer Prevention Research showed that curcumin suppresses the ability of colon cancer cells to proliferate, suggesting it is helpful both in the prevention and treatment of the condition.

Curcumin Exerts Effects on the Pathophysiology of Alzheimer's Disease
Frontiers in Neurology,
November 2017
Curcumin, a major polyphenol from curry spice (Curcuma longa), has been reported to inhibit Aβ aggregation, Aβ-induced inflammation, and the activities of β-secretase and acetylcholinesterase in in vitro studies (12, 13). Moreover, in in vivo studies, oral administration of curcumin has resulted in the inhibition of Aβ oligomerization, Aβ deposition, and tau phosphorylation in the brains of AD animal models, as well as led to the improvements in behavioral impairment in animal models (12). In our previous study, we found that chronic curcumin administration ameliorates Aβ1-42 induced AD-related cognitive deficits (13). However, more information underlying the mechanism should be explored. Based on these research results, we speculated that curcumin may ameliorate AD pathogenesis by regulating PI(3,5)P2 and TRPML1 expression levels. To validate it, we first detect the effects of curcumin on lysosomes and the cell viability of hippocampal HT-22 cells that treated with Aβ1-42. Sequencing technique was then used and TRPML1 was identified as the most upregulated gene that affected by curcumin. Afterward, the effects of curcumin on the autophagy-related proteins were also analyzed in vitro. Besides, we also determined that curcumin ameliorated autophagy–lysosome dysfunction by regulating PI(3,5)P2 and TRPML1 in vivo. Our study suggests that curcumin might be one of the most promising compounds for the interference of AD therapies.

Turmeric is the spice of the year
Lifestyle.ynaija.com, November 2017
Turmeric's major component is curcumin, a powerful, medicinal substance that has anti-inflammatory properties, helps fight cancer and diabetes, aids digestion, combats heart diseases, works as an anti-oxidant, works magic on the skin, reduces bloating, calms severe menstrual pain and essentially, solves more than a handful of life’s problems. Turmeric tea has potential to ease health conditions such as Alzheimers, athritis, obesity and chest pain. Its anti-inflammatory properties help boost the immune system and protect the brain. Its principal component, curcumin also contains anticancer properties and has been found useful in the treatment of brain, bone and breast cancer.

The anti-inflammatory activity of curcumin
Journal of Biological Chemistry, November 2017
The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory remedy in traditional Asian medicine for centuries. Many cellular targets of curcumin have been identified, but how such a wide range of targets can be affected by a single compound is unclear. We conclude that the paradigm of metabolic bioactivation uncovered here should be considered for the evaluation and design of clinical trials of curcumin and other polyphenols of medicinal interest.

Turmeric may reduce inflammation from osteoarthritis
Daily Herald, November 2017
Over the past two decades there have been many medical studies evaluating the effect of turmeric extracts including curcumin and reducing the pain and inflammation associated with osteoarthritis. The overall results of these studies strongly indicate that curcumin and other extracts of turmeric reduce inflammation as well as pain levels in patients with osteoarthritis. A recent study published in the Journal of Medicinal Food demonstrated that extracts of turmeric have a significant impact on the inflammation and pain associated with osteoarthritis. The study was a meta-analysis, which means that it combined the data from many smaller studies and the final result indicated that an ancient spice is very effective at reducing the inflammation and associated symptoms of osteoarthritis. This meta-analysis included middle-aged and elderly people who have symptoms of osteoarthritis in five or more joints. All of the studies demonstrated a significant reduction in pain and stiffness. They also concluded that approximately 1000 mg of curcumin a day gave a reduction in symptoms equivalent to over-the-counter analgesics. This is important because turmeric extracts and curcumin do not have the same gastrointestinal and heart-related side effects (bleeding, high blood pressure and increased risk of heart attack) associated with commonly used pain medications. The side effects seem to be increased in the elderly -- the very people most affected by osteoarthritis.

Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor
Proceedings, November 2017
Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study showed that curcumin suppresses tumor progression, and alleviates the lipid peroxidation and improves antioxidant status in the tissues of solid tumor-bearing mice.

Turmeric's Anti-Inflammatory Properties
Science Trends, November 2017
It has been suggested that the compound curcumin helps the immune system destroy amyloid plaque, reducing the production of inflammatory cytokines. In doing so, brain function deterioration is reduced, slowing down the development of Alzheimer's disease. Epidemiological studies have looked at the neuroprotective effect of curcumin and have demonstrated that regular consumption has reduced other cognitive deficits in the elderly. Over the years curcumin has been a main focus for research regarding its strong anti-tumor effects. In fact, several preclinical trials have demonstrated curcumin to have both chemopreventive and anti-tumor effects against certain types of cancer. This naturally occurring polyphenolic compound recently has shown promise as a dietary therapy for pancreatic cancer. Of course, it shouldn't be thought of as a primary means for treating cancer, but it may reduce tumor promotion and minimize the spread of cancer. Turmeric has anti-inflammatory abilities containing more than two dozen compounds which may help relieve osteoarthritis pain. Again, it’s the compound curcumin that works as an anti-inflammatory agent. Clinical studies have found that curcumin provided protection to joint inflammation in individuals with osteoarthritis. Ulcerative colitis is a chronic, inflammatory bowel disease causing inflammation in the digestive tract. The disease tends to flare up and subside at random. Studies have shown people with ulcerative colitis who took curcumin had a significantly lower relapse rate than people who did not take curcumin. A meta-analysis showed curcumin had a high effect in reducing symptoms of depression, such as irritable mood, reduced interest in pleasurable activities, fatigue or feelings of worthlessness. The analysis suggests that curcumin could possibly have a role in treating the symptoms of major depression.

Curcumin suppresses Notch‑1 signaling: Improvements in fatty liver and insulin resistance in rats
Molecular Medicine Report, November 2017
Curcumin is a well‑known phenolic substance and has many pharmacological effects associated with metabolism. Curcumin administration led to a downregulation in the expression of lipogenic genes, including sterol regulatory element‑binding protein, fatty acid synthase and acetyl‑CoA carboxylase (P<0.05). The expression of inflammation‑associated genes, including nuclear factor‑κB, tumor necrosis factor‑α and prostaglandin‑endoperoxide synthase 2 were also suppressed. The results of the present study suggest that the hepatic Notch‑1 pathway can be suppressed via curcumin treatment, which may ameliorate fatty liver and insulin resistance in rats subjected to a high fat diet.

Foods for brain memory and function
The Medium, November 2017
According to Uma Naidoo, turmeric is an ingredient found in curry that appears to be responsible for de-plaguing the brain. Naidoo also explains that turmeric, also referred to as "Indian gold," has properties that benefit the brain, making you almost as bright as its own fiery complexion. The ingredient responsible for this powerful herb's effects on the brain is known as curcumin. Naidoo says, “Curcumin has been found to possess neuroprotective properties, and may help shield the brain against Alzheimer’s disease (AD) by binding to and eliminating toxic beta-amyloid plaques, which are a hallmark of AD."

Anti-neuroinflammatory effect of curcumin
International Journal of Molecular Medicine, November 2017
Curcumin is the main curcuminoid present in Curcuma longa and it has been previously reported to exhibit a wide range of pharmacological activities. Curcumin suppressed the secretion of inflammatory mediators through an increase in the expression of HO-1. Curcumin induced HO-1 transcription and translation through the Nrf2/antioxidant response element signaling pathway. Inhibitory experiments revealed that HO-1 was required for the anti-inflammatory effects of curcumin. Further mechanistic studies demonstrated that curcumin inhibited neuroinflammation by suppressing NF-κB and MAPK signaling pathways in Pam3CSK4-activated microglial cells. The results of the present study suggest that curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders.

Terrific Turmeric
Steinbach Online, November 2017
Due to recent research, curcumin has been nicknamed the "master off-switch for inflammation." It has been shown to help relieve pain and inflammation by modulating the inflammatory pathways that affect heart, joints, liver, gastrointestinal tract, brain, cellular health and the immune system! This makes curcumin useful for relieving the pain in osteoarthritis, rheumatoid arthritis and bursitis as well as in digestive conditions such as ulcerative colitis, Crohn's disease, celiac disease, gastritis and gastric ulcers. Curcumin has the ability to block more than 30 different inflammation pathways! Curcumin also protects against inflammatory calcium loss from our bones and has been shown to slow prostate cell proliferation in addition to supporting healthy cholesterol and blood pressure levels. Curcumin has liver-protective effects and is a powerful liver detoxifier. It helps to prevent the build-up of toxins, enhance glutathione levels, supports bile production and solubility as well as improve digestive function. Curcumin may help reverse certain forms of liver cirrhosis to some degree, and is thought to be especially helpful for people who regularly drink alcohol or use common painkillers, both of which damage cause liver damage. Studies suggest that curcumin can also reduce the severity of liver injury induced by iron overdose, cholestasis and carbon tetrachloride intoxication. In addition to supporting the liver processes, managing inflammation is also vital in aiding detoxification. Inflammation control is needed because the detoxification process involves the release of toxic metabolites from our cells and tissues in order to expel them from the body. On the way to being eliminated, these toxins can trigger inflammatory reactions and cause tissue damage. 
Curcumin, was originally researched for Alzheimer's disease because studies found there is a much lower incidence and prevalence of Alzheimer's in India than in North America. The association between curry consumption and cognitive level in certain populations were researched and it was found that those who ate curry foods performed better on a standard test than those who never or rarely ate curry! Alzheimer's disease degrades the nerve cells in the brain through inflammation in glial cells, the formation of beta-amyloid plaques, metal toxicity, and oxidative damage. Curcumin acts as a powerful anti-inflammatory and antioxidant in the brain. It can also break down plaques and has the potential to guard against their development, plus it supports healthy neurotransmitter function, improving memory and helping to prevent cognitive decline. 

Curcumin alleviates liver oxidative stress in type 1 diabetic rats
Molecular Medicine Reports, November 2017
The aim of the present study was to determine the effects of curcumin on antioxidants using a rat model of type 1 diabetes. The results provide evidence that oxidative stress in the STZ‑induced diabetic rat model may be attenuated by curcumin via the activation of the Keap1‑Nrf2‑ARE signaling pathway, as evidenced by a decrease in the blood glucose concentration and an increase in the transcription of several antioxidant genes.

Natural ingredients to help manage aches and pains
Body and Soul, November 2017
Turmeric is best known as a powdered spice used to give foods flavour and colour – think curries. It contains a natural chemical compound called curcumin that scientists have found to have anti-inflammatory and antioxidant properties. Research suggests turmeric and its components can potentially alleviate arthritis inflammation and pain. With curcumin accounting for only 3-5% of turmeric, you’re unlikely to get enough from diet alone, so consider a supplement to help boost levels.

Protective Effect of Curcumin Against Oxidative Stress-Induced Injury in Rats with Parkinson's Disease
Cellular Physiology and Biochemistry, November 2017
Background/Aims: The study aimed to investigate the protective effect of curcumin against oxidative stress-induced injury of Parkinson’s disease (PD) through the Wnt/β-catenin signaling pathway in rats. This study suggests that curcumin could protect against oxidative stress-induced injury in PD rats via the Wnt/β-catenin signaling pathway.

Keep breast cancer at bay
Telangana Today, November 2017
The spice that gives curry its beautiful yellow colour contains a chemical called curcumin. The studies have shown that curcumin supplements could play a role in helping fight breast cancer tumours.

Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats
Nutrients, November 2017
Curcumin has been proven to have a weight-loss effect in a menopausal rat model induced by ovariectomy. In conclusion, estrogen deficiency induced by ovariectomy caused changes in the distribution and structure of intestinal microflora in rats, and curcumin could partially reverse changes in the diversity of gut microbiota.

Reduce Inflammation with an Ancient Wonder Herb
Huffington Post, November 2017
Curmeric is a spice and a part of the ginger family that has been used for thousands of years. It's rich in a powerful natural phenol called curcumin. This wonder herb has been shown to be effective in treating low moods, either alone or in combination with an antidepressant. Curcumin contains powerful phytochemicals that reverse inflammation, and chronic inflammation has been shown to contribute to the development of a wide variety of disorders, depression being one that may be closely linked. A 2014 randomized control study compared three groups of 20 participants each. The three groups were given curcumin alone, Prozac® + 1g of oil based curcumin, or Prozac alone for a six-week period. They then had their low moods measured on a common scale. Surprisingly, the group on curcumin alone did just as well as those on Prozac alone. While there was not a major statistical significance among any of the three groups, the group on the combination scored best. The researchers found no safety concerns with the daily curcumin usage and concluded "This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD [major depressive disorder] without concurrent suicidal ideation or other psychotic disorders.”

Curcumin modulates covalent histone modification and TIMP1 gene activation to protect against vascular injury in a hypertension rat model
Experimental and Therapeutic Medicine, November 2017
Hypertension is a leading risk factor for morbidity and mortality. Previous studies have reported that curcumin has anti‑oxidation and anti‑aging effects and inhibits histone deacetylase activity. In conclusion, curcumin could relieve extracellular matrix degradation and interstitial fibrosis induced by hypertension, and lower blood pressure. It could also serve a function in improving vascular structure through inhibiting the expression of HDAC1, thereby promoting TIMP1 transcription activation and suppressing the expression of MMP‑2 and TGFβ.

Turmeric Is a Top Culinary Medicine
Natural Products Insider, November 2017
Nutritionists, functional medicine GP's and physiotherapists commonly use curcumin for it's anti-inflammatory qualities. And it's no wonder considering six major scientific trials all found curcumin to possess a potent anti-inflammatory action, which is completely non-toxic in nature.  A study evaluating several pharmaceutical anti-inflammatory drugs, found that aspirin and ibuprofen are the least potent, while curcumin is among the most potent anti-inflammatory and anti-proliferative agents available.. Arthritis is a debilitating inflammatory disorder. Thankfully curcumin has been found to help. A recent study out of Japan evaluated its relationship with the inflammatory cytokine known to be involved in in the rheumatoid arthritis process. Scientists discovered that curcumin "significantly reduced" these inflammatory markers. In fact its anti-inflammatory qualities are so strong a 2007 study compared curcumin and cortisone and found they were equal in potency! Most pharmaceutical anti-inflammatory drugs are contraindicated to use over the long-term, but turmeric is not only safe but beneficial for your overall well-being. Curcumin has been shown to equal in effectiveness to the drug metformin in the management of diabetes, but without negative side effects. (5) In the study curcumin was shown to lower blood glucose levels and reverse insulin resistance by suppressing glucose production in the liver. Another study found curcumin improved metabolic function and reduced the risk of plaque buildup in the arteries of type-2 diabetes patients. (6) Curcumin also acts as an anti-diabetic and antioxidant in patients with type-1 diabetes. With anti depressants prescriptions on an all time high, there has been a flood or recent trials attempting to get to the cause of depression. The core issue has finally been identified as inflammation. And curcumin has been found to be comparable to prescription antidepressant drugs.. In 2014 a randomized control trial took 60 volunteers diagnosed with major depressive disorder (MDD) and compared the effect of curcumin to fluoxetine (Prozac). (9) Researchers discovered that the principal curcuminoid in turmeric is not only as effective as Prozac in managing depression, but it doesn't carry with it all the dangerous side effects as anti-depressive drugs do. According to the paper, "This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD.”

Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors
Nutrition Journal, November 2017
Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs.

Curcumin Shrinks Aggressive Mesothelioma Tumors in New Study
Surviving Mesothelioma, November 2017
The latest study of cucumin in malignant mesothelioma treatment was conducted by French scientists at several different research centers. The team used cells taken from rats that had been induced to develop one of the deadliest and most aggressive subtypes of asbestos cancer called sarcomatoid mesothelioma. The rats began to develop sarcomatoid mesothelioma tumors in their abdomens within weeks of being injected with asbestos. The French scientists tested curcumin on cells from these tumors to determine the ideal killing dose. The team then used the sarcomatoid mesothelioma rats to test the treatment in vivo, in living animals. Compared with an epigenetic drug called SAHA, curcumin injected directly into the peritoneal cavities of sick rats was more effective and started to destroy their tumors in less two weeks. "The treatment of tumor-bearing rats with 1.5 mg/kg curcumin on days 7, 9, 11 and 14 after tumor challenge dramatically reduced the mean total tumor mass at day 16," reports Dr. Daniel L. Pouliquen, lead author on the report in Oncotarget. Earlier this year, scientists in the Department of Experimental Medicine at the University of Rome conducted a similar experiment and that found that intraperitoneal curcumin extended survival in mice with mesothelioma. In 2015, mesothelioma researchers with Flinders University in Australia determined that curcumin had the ability to keep mesothelioma tumors from giving rise to their own new blood vessels. That study suggested that curcumin could become a supplemental treatment for certain mesothelioma patients.

Curcumin is able to inhibit breast cancer cells
Oncology Letters, October 2017
The present study investigated the inhibitory effect of curcumin on human breast cancer MCF‑7 cells and investigated the potential underlying molecular mechanisms. MCF‑7 cells were cultured with curcumin at different concentrations and time points.  The proliferation of MCF‑7 cells in the group treated with curcumin was markedly decreased compared with the control, with the greatest inhibitory effect at a concentration of 20 µM. The expression of Bax mRNA was increased and Bcl‑2 mRNA expression was decreased compared with the control. Additionally, protein expression of NF‑κB and IκB was increased. The data indicate that curcumin is able to inhibit breast cancer cell proliferation, possibly by regulating the NF‑κB signaling pathway.

The Remarkable Anti-Cancer Activities of Curcumin
Experiment.com October 2017
Curcumin, a  diferuloylmethane, is a phytochemical derived from the rhizome of Curcuma longa, a member of the ginger family. It has been  used orally and safely as a spice and for medicinal purposes for many thousands of years in southern Asia and India. There are
 numerous published articles on laboratory, animal, and human studies examining its  effect as an anti-proliferative and anti-inflammatory on a wide variety of diseases.     It enhances induction of tumor antigen-specific, PD-1-positive,,    Cytotoxic T Lymphocytes [the Death Receptor] (1,2);,,    It arrests cancer, cells in various phases of the cell cycle, and induces apoptosis primarily through a,     mitochondrial pathway involving,, caspase-8-dependent BID cleavage (3);,,    It has been shown,     to inhibit constitutive NF-kB activation, induce G1/S arrest,,, suppress proliferation, and induce apoptosis in mantle cell lymphoma (4);,,    It induces apoptosis in human melanoma cells  through a Fas Receptor/Caspase-8 pathway,     independent of p53 (5);,,    It suppresses the proliferation of human vascular endothelial cells,,    in vitro and inhibits the Fibroblast Growth Factor-2-induced angiogenic,,    response in-vivo (6);,,    It induces apoptosis in the human acute myelogenous leukemia cell, line HL-60, believed to,     occur through the mitochondrial pathway involving caspase-8, BID cleavage,,     cytochrome C release, and caspase-3 activation (7);,,    It downregulates action of NF-kB and the antiapoptotic genes,,    regulated by NF-kB,,     a critical role in inhibiting cancer cell survival and proliferation in pancreatic cancer (8);,,    It suppresses expression of NF-kB, Bcl-2 and Bcl-XL in multiple,,    myeloma cell lines (9);,,    It potentiates the antitumor activity of gemcitabine in an in-vivo,, pancreatic cancer model through,     suppression of proliferation, angiogenesis, and inhibition of NF-kB -regulated,     gene products (10);,,    It induces gemcitabine sensitivity in pancreatic cancer cells through modulation of miR-200 and miR-21,     expression (11);,,    It inhibits tumor growth and angiogenesis in an orthotopic mouse model of,,    human pancreatic cancer (12);,,,    A liposomal-encased,     formulation of curcumin was studied in pancreatic cancer cell lines in vitro and in vivo, by, intravenous infusion, in athymic mice at the M.D. Anderson Cancer Center in,     Houston, Texas. Liposomal Curcumin was shown to down-regulate the NF-kB,     machinery, suppress tumor growth, and induce apoptosis in vitro, and demonstrated a reduction in, tumor burden and angiogenesis in vivo (13);,,    It inhibits growth and survival of human head and neck squamous carcinoma cells with modulation of of,     NF-kB signalling (14).

A Powerful And Cheap Supplement That You Aren't Using Enough
MensXP.com October 2017
The effects of curcumin are very similar to any synthetic anti-inflammatory drug. While synthetic drugs have side effects and may only be prescribed when needed, curcumin on the other hand, is a natural substance without side effects. Inflammation is an essential physiological function. Without our body's inflammation mechanism we would have no protection against pathogens. Although, short term (acute) inflammation works in our favor, but prolonged (chronic) inflammation which is a result of modern day stressful lifestyle is a key contributor to many western diseases. This includes heart disease, cancer, metabolic syndrome, Alzheimer's and much other health detrimental conditions. Including curcumin in the diet ensures the prevention of chronic inflammation. This is one benefit that our grandmother knew well before science confirmed it. This is the reason why you got a glass of hot milk mixed with turmeric every time you got injured. Curcumin is proven to relieve pain significantly at higher doses of 400-500mg. The pain relief benefits were found in post-operative patients and people suffering from arthritis and osteoporosis. This is comparable to 2g acetaminophen in potency. (a powerful painkiller).

Turmeric is a potential aid against precancerous cells
The Plaid Zebra, October 2017
Curcumin is one of the most powerful non-pharmaceutical anti-inflammatory compounds out there. It may provide the greatest benefits for stomach, breast, skin, bowel, brain, ovarian, colon, and prostate cancers. In fact, The American Cancer Society says that turmeric can be a potential treatment. It works by protecting the body from free radicals. Studies have also shown that curcumin also interrupts the progression, spread, and growth of cancerous cells. It also helps with the inflammation that is associated with the progression of cancer. The American Cancer Society mentions a study in which curcumin kills cancer cells in isolation, as noted in laboratory dishes.,,Curcumin inhibits COX-2, the enzyme that leads to negative inflammation that eventually leads to cancer. It also takes away the oxygen that fuels cancer cells. Additionally, it kills large cell B-cell lymphoma cells, and prevents the rebirth of cancer stem cells. Turmeric and curcumin have anti-carcinogenic agents. Carcinogens are greatly impactful to the development of cancerous cells. It mediates anti-carcinogenic action by raising levels of antioxidant enzymes. Curcumin and its derivatives are associated with anti-tumour activity.

Curcumin and Pancreatic Cancer Treatments
HealthProfessionalRadio.com October 2017
Ajay Goel, PhD., is Director of Translational Genomics and Oncology, and the Director of the Center for Gastrointestinal Research at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, TX. He is currently researching the prevention of gastrointestinal cancers using integrative and alternative approaches, including botanical products. Two of the primary botanicals he is investigating are curcumin (from turmeric) and boswellia.  Dr. Goel is a member of the American Association for Cancer Research and the American Gastroenterology Association and is on the international editorial boards of World Journal of Gastroenterology and World Journal of Gastrointestinal Oncology. Segment overview: Dr. Ajay Goel, PhD, senior author on a recent study published in the Oxford University Press’ journal “Carcinogenesis” that shows clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in pancreatic cancer patients.

Neuroprotective effects of curcumin
Molecular Medicine Reports, October 2017
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. The results of the present study suggest that pretreatment with curcumin can prevent the development of LIDD in rats. It was revealed that treatment with curcumin significantly reduced interleukin (IL)‑1β and IL‑6, iNOS, COX‑2 and MMP‑9 levels in rats with LIDD. In addition, treatment with curcumin reduced the mRNA expression levels of TGF‑β1 and TGF‑β2, whereas it increased the mRNA expression levels of BDNF in rats with LIDD. In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF.

A compound in turmeric could make cancer cells more sensitive to radiation
 Scroll, September 2017
Pre-treatment with curcumin – a safe herbal compound derived from turmeric – makes cancer stem cells sensitive to radiation therapy. It has found that combined effect of curcumin and exposure to radiation was markedly more effective in lowering AP-1 levels thereby rendering cells unviable for growth and replication. When treated with radiation alone, there was delayed but increased rate of proliferation and tumor formation. The mechanism of curcumin-induced inhibition lends credibility to AP-1 as a drug target and therapeutic utility of curcumin for radio-sensitisation of cervical cancer stem cells for better treatment outcomes.

Natural ways to support a healthy liver
News-Medical.net September 2017
Turmeric is a bright orange spice which has been long used in Indian cuisine and Ayurvedic medicine. Turmeric is reported to have the ability to protect the liver from damage. Animal studies have shown that mice fed curcumin, one of the active ingredients in Turmeric, suffered less liver damage over time compared with those on a normal diet. Curcumin has even been found to have a beneficial effect in the treatment of liver disorders

Investigating the effect an over-the-counter anti-inflammatory supplement called Curcumin has on the onset of Alzheimer’s.
AustralianAgeingAgenda.com September 2017
The preliminary findings suggested a longer period of time taking the supplement was required and the study has been extended for two years, Dr Goozee said. “We believe having people on the long-term Curcumin may have some benefit in being able to slow their accumulation or reduce what’s already there.”

Curcumin inhibits endoplasmic reticulum stress
Experimental and Therapeutic Medicine, September 2017
The aim of the present study was to observe the dynamic changes of the growth arrest and DNA damage‑inducible 153 (GADD153) gene and caspase‑12 in the brain tissue of rats with cerebral ischemia‑reperfusion injury (CIRI) and the impact of curcumin pretreatment. A total of 60 rats were randomly divided into the normal group (N), the sham operation group (S), the dimethyl sulfoxide control group (D) and the curcumin treatment group (C). For group D and C, 12 (T1), 24 (T2) and 72 h (T3) of reperfusion were performed after 2 h ischemia. The expression levels of GADD153 and caspase‑12 in the brain tissue were detected and compared among the groups by immunohistochemistry, immunofluorescence double staining and western blotting. The expression levels of GADD153 and caspase‑12 were increased at T1compared with groups N and S, and the expression of caspase‑12 peaked at T2 in group D, while GADD153 was increased until T3 in group D. Compared with group D, the expression levels of GADD153 and caspase‑12 in group C at T2 and T3 were significantly decreased (P<0.05). Endoplasmic reticulum stress is involved in the pathological process of CIRI. Curcumin may decrease the expression levels of the above two factors, thus exhibiting protective effects against CIRI in rats.

Can curry spice really help banish your aches and pains? Yes - and women may benefit from nature's painkiller the most
DailyMail, September 2017
Curcumin is a strong anti-inflammatory agent and chronic inflammation is the precursor of the vast majority of cancers.,,Turmeric helps cells regulate their growth and survival, including the recycling of worn out cells, and the self-destruction of abnormal cells which have the potential to form tumours. Turmeric is traditionally used to support weight loss. Curcumin boosts the metabolic rate of ‘good’ brown fat cells so they burn more fat as a fuel – this is one reason why you may find yourself sweating after eating a spicy curry.,,The latest news is that curcumin also helps to regulate the production of hormones linked with obesity, such as resistin (which links obesity with insulin resistance and type 2 diabetes), leptin (the satiety hormone) and adiponectin (a hormone involved in fat breakdown). Curcumin has beneficial effects against skin inflammation by quenching free radicals, reducing inflammation.,,In psoriasis, this helps to slow the over-production of cells that lead to plaque formation.

Curcumin Alleviates the Functional Gastrointestinal Disorders of Mice In Vivo
Journal of Medicinal Food, September 2017
Curcumin is a natural polyphenol extracted from the turmeric rhizome, which has a wide range of biological activities, but until now the effects of curcumin on the gastrointestinal peristalsis have not been fully understood. In vivo study, we observed the effects of curcumin on gastric emptying and intestinal propulsion rates of mice in normal state and in delayed state by atropine (ATR) or nitric oxide precursor L-arginine (L-Arg). An in vitro study explored the direct effects of curcumin on the intestinal contractility, but were studied through measuring spontaneous contraction of isolated jejunum of mice. Our results showed that intragastric administration of curcumin (200 mg/kg/day) for 10-20 days significantly improved gastric emptying and intestinal propulsion rates of mice delayed by ATR. Moreover, intragastric administration of curcumin (200 mg/kg/day) for 15 days also significantly improved mice gastric emptying and intestinal propulsion rates delayed by L-Arg.

Potential Role of Curcumin Against Biofilm-Producing Organisms on the Skin: A Review
Phytotherapy Research, September 2017
Turmeric root (Curcuma longa) is predominantly used as a spice, but has also long been known to possess antimicrobial, analgesic, antiinflammatory, and anticancer properties. One predominant group of active compounds in turmeric are curcuminoids, namely bright yellow-pigmented curcumin. While modern science has yet to fully investigate the therapeutic claims of turmeric and its derivatives, results have proven promising in decreasing pain and inflammation in arthritis, improving insulin sensitivity in diabetes, and even curing a variety of infections.  Curcumin has demonstrated bactericidal efficacy against a variety of infections when administered with antibiotics in several clinical studies, with consistent antimicrobial activity demonstrated in vitro, as well as in urinary tract infections, gingival infections, and chronic wound infections. Hypothesized mechanisms of action include curcumin's ability to perturb bacterial membranes, disturb protofillament assembly, and even impair bacterial virulence factors.

Shield against Alzheimer's dementia
Times of India, September 2017
"Turmeric contains a curcumin, the bright yellow chemical that gives turmeric its colour, which acts like a protective shield towards the problem," he added. There is a great body of evidence to prove the positive impact of turmeric on prevention and treatment of AD. As per Antioxidants-2016 - an academic publication of Multidisciplinary Digital Publishing Institute (open-access publisher), termed turmeric as an alternative therapy for AD. Similarly, London based Alzheimer's society noted that curcumin in turmeric can break down Amyloid-beta plaques (amino acids that play a key role in development of dementia).

Health Benefits of Turmeric: 5 Proven Benefits of Turmeric
India.com September 2017
Curcumin present in turmeric improves the brain function by boosting Brain-Derives Neurotrophic Factor (BDNF), a growth hormone present in the brain. It drives the process of formation of new neuron connections. Neurons develop new connections in a specific area of the brain. Turmeric also helps lower the risk of brain diseases by boosting BDNF in the brain. The increased levels of BDNF delays or reverses several age-related brain damages and brain diseases. Turmeric contains curcumin, which is beneficial for your heart. Curcumin improves your heart health by improving the function of the blood vessel lining called endothelium. According to some studies, curcumin improves the endothelium function. Studies showed that it is as effective as the drug Atorvastatin or works as well as exercises. Curcumin also reduces oxidation and inflammation, which in turn improve the heart health.

Long-term stabilisation of myeloma with curcumin
British Medical Journal, August 2017
Here, we describe a myeloma patient who started a daily dietary supplement of curcumin when approaching her third relapse. In the absence of further antimyeloma treatment, the patient plateaued and has remained stable for the last 5 years with good quality of life. Curcumin is a polyphenol derived from the perennial herb Curcuma longa (turmeric) and has, for centuries, been used as a traditional Indian medicine. Several reports published over the two decades have claimed various health benefits of curcumin and this has led to its increasing popularity as a dietary supplement to prevent or treat a number of different diseases. The biological activity of curcumin is indeed remarkable. It is a highly pleiotropic molecule which possesses natural antioxidant, anti-inflammatory, antiseptic and analgesic properties. More recently, it has demonstrated antiproliferative effects in a wide variety of tumour cells including myeloma cells and exerts its antiproliferative effects through multiple cellular targets that regulate cell growth and survival.

New science confirms curcumin every day reverses cancer
Natural News, August 2017
A report in the British Medical Journal illustrates how a woman has beaten blood cancer with the help of turmeric. In 2007, 67-year-old Dieneke Ferguson was diagnosed with myeloma and she progressed to stage three within 15 months. Three failed rounds of chemotherapy and four failed stem cell transplants later, doctors told her she had very little hope. Four years after her initial diagnosis, she took matters into her own hands and started taking a daily dose of curcumin, the key component of turmeric. She took eight grams every evening on an empty stomach.
Since then, her cancer has stabilized and her blood counts have returned to normal. The BMJ report says that Ferguson’s results suggest that turmeric could be used to help myeloma patients in the future, adding: “The fact that our patient, who had advanced stage disease and was effectively salvaged while exclusively on curcumin, suggests a potential antimyeloma effect of curcumin.” No other possible explanation for her recovery. The report’s co-author, Jamie Cavenagh, said that there is no other possible explanation for her remarkable recovery beyond the curcumin. She continues to take the tablets to this day. The scientists are recommending further evaluation in clinical trials to pursue the possibility of using it as an official treatment. This could prove difficult, however, because doctors cannot prescribe it until it has been tested in wide-scale trials that cost millions. Natural compounds cannot be patented, so finding an investor would be extremely difficult.

Turmeric helped cancer patient, 57, beat myeloma after five years of treatment
The Sun, August 2017
Dieneke Ferguson took eight grams of curcumin each night for five years and her cancer has remained stable. Curcumin is a polyphenol derived from the perennial herb turmeric and has been used as a traditional Indian medicine for centuries.  Curcumin is a natural antioxidant, anti-inflammatory, antiseptic and has analgesic properties, according to the BMJ report.  More recently, it has demonstrated an ability to slow or inhibit cell growth in a wide variety of tumour cells, including myeloma.  It has also been found to help alleviate a range of other health problems.

Turmeric may help fight the most common type of cancer found in infants
Mic.com August 2017
A popular spice frequently used in curries may be combatting the most common cancer cells afflicting infants, according to a recent study. Turmeric, a vibrant yellow spice seen in dishes such as roasted vegetables and soups, contains a chemical called curcumin. Recent research suggests that curcumin helps destroy neuroblastoma tumor cells, which often start in the embryo or fetus. These particular tumor cells can become resistant to drug treatments, scientists say, meaning that a new treatment plan involving turmeric could make all the difference. For children, neuroblastoma can be a severe health obstacle. About 700 new cases appear each year in the U.S., mostly diagnosed in kids younger than age 5. This type of cancer can delay development and cause hearing loss or other disabilities. That aside, the medical treatment itself can be difficult: Kids can suffer serious side effects or damage from traditional methods such as chemotherapy, for example. “This research demonstrates a novel method of treating this tumor without the toxicity of aggressive therapy that can also have late effects on the patient’s health,” Tamarah J. Westmoreland, a lead researcher on the study, said in a release.

Chemical from turmeric helps treat cancer in children: Study
TheHindu.com August 2017
Scientists in the U.S. have found yet another use for curcumin, the bioactive component of turmeric that is widely used in Indian cuisine, this time to treat cancer in children. Researchers at Nemours Children’s Hospital and the University of Central Florida (UCF) have found that nanoparticles loaded with curcumin can target and destroy neuroblastoma tumour cells. Children aged five or less are most commonly affected. In their study, the researchers attached curcumin to cerium oxide nanoparticles and tested the nano-curcumin formulation in cell lines of a high-risk form of neuroblastoma. “This formulation induced substantial cell death in neuroblastoma cells while producing no or only minor toxicity in healthy cells,” says the report published in Nanoscale . Curcumin has been shown to have substantial anti-cancer ability, but its low solubility and poor stability have restricted its use in therapeutic applications. The study demonstrates a treatment method “without the toxicity of agressive therapy” and shows that nanoparticles can be “an effective delivery vehicle” for cancer drugs, said a statement from UCF.

Starving Prostate Cancer With What You Eat for Dinner
University of Texas, August 2017
Curcumin combined with other nutrients has anti-cancer properties. The researchers first tested 142 natural compounds on mouse and human cell lines to see which inhibited prostate cancer cell growth when administered alone or in combination with another nutrient. The most promising active ingredients were then tested on model animals: ursolic acid, a waxy natural chemical found in apple peels and rosemary; curcumin, the bright yellow plant compound in turmeric; and resveratrol, a natural compound common to red grapes or berries. “These nutrients have potential anti-cancer properties and are readily available,” says Tiziani. “We only need to increase concentration beyond levels found in a healthy diet for an effect on prostate cancer cells.” The new research paper also demonstrates how the plant-based chemicals work together. Combining ursolic acid with either curcumin or resveratrol prevents cancer cells from gobbling something that they need to grow, glutamine. This is a neat solution: blocking the uptake of a nutrient needed by prostate cancer cells with nutrients that are commonly in the human diet.

Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation
Molecular Medicine Reports, August 2017
curcumin exerts a marked effect on aortic aneurysm development. In rat tissues, treatment with curcumin resulted in reduced aneurysm size and restored the wavy structure of the elastic lamellae. In addition, curcumin decreased neovascularization and the expression of VEGF. Immunohistochemical analysis indicated that curcumin significantly inhibited infiltration of cluster of differentiation (CD)3+ and CD68+ cells in TAA. Furthermore, curcumin treatment decreased the expression of vascular cell adhesion molecule‑1, intracellular adhesion molecule‑1, monocyte chemoattractant protein‑1 and tumor necrosis factor‑α. Collectively, the results demonstrated that angiogenesis and VEGF expression were increased in the aortic wall in TAA. Treatment with curcumin inhibited TAA development in rats, which was associated with suppression of VEGF expression. In addition, curcumin attenuated inflammatory cell infiltration and suppressed inflammatory factor expression in the periaortic tissue of TAA.

Underlying Mechanisms ID'd in Curcumin Resensitization of CA Cells
HealthDay News, August 2017
Curcumin can resensitize chemoresistant pancreatic ductal adenocarcinoma (PDAC) cells through inhibition of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis, according to a study published online July 17 in Carcinogenesis. The researchers reported the resensitization of chemoresistant PDAC cells by curcumin through inhibition of the PRC2-PVT1-c-Myc axis. Curcumin sensitized chemoresistant cancer cells inhibited expression of the PRC2 subunit enhancer of zeste homolog-2 and its related long non-coding RNA PVT1 using gemcitabine-resistant PDAC cell lines. Curcumin also prevented spheroid formation and down-regulated several genes driving self-renewal. In vitro findings were confirmed in a xenograft mouse model, with inhibition of gemcitabine-resistant tumor growth by curcumin. "Overall, this study establishes clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC," the authors write.

Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression
Carcinogenesis, August 2017
Accumulating evidence indicates that curcumin, a phenolic compound extracted from turmeric, can overcome de novo chemoresistance and re-sensitize tumors to various chemotherapeutic agents. Using gemcitabine-resistant PDAC cell lines, we found that curcumin sensitized chemoresistant cancer cells by inhibiting the expression of the PRC2 subunit EZH2 and its related lncRNA PVT1. Curcumin was also found to prevent the formation of spheroids, a hallmark of CSCs, and to down-regulate several self-renewal driving genes. In addition, we confirmed our in vitro findings in a xenograft mouse model where curcumin inhibited gemcitabine-resistant tumor growth. Overall, this study indicates clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC.

Kitchen spice helps woman beat cancer
israelnationalnews.com August 2017
Dieneke Ferguson, 67, battled myeloma for five years, thought she had lost, and then tried a key component of a common kitchen spice: curcumin. Now, five years later, her cancer cell count is negligible, the Daily Mail reported.  Her recovery was so remarkable it was featured in the British Medical Journal. However, the report emphasized that few - if any - of myeloma sufferers used curcumin on its own, without conventional treatments.  And co-author Jamie Cavenagh, who works at London’s Barts Hospital as a specialist in blood disease, said many of his patients take curcumin at some point, but it doesn't work for everyone.  "A lot of my patients take curcumin at different stages of their treatment. I don’t object to it," Cavenagh said. " Dieneke’s is the best response I have observed and it is clear-cut because we had stopped all other treatment. I have not seen such a convincing response before."  "When you review her chart, there’s no alternative explanation [for her recovery] other than we’re seeing a response to curcumin."  Myeloma is a type of blood cancer, and to treat it, Ferguson first tried three rounds of chemotherapy and four stem cell transplants.  Ferguson currently takes 8 grams of curcumin a day (equivalent to two teaspoons of powered curcumin), mostly to ensure the disease does not come back.

Cancer breakthrough: Trendy spice could be key to killing tumours
Express, August 2017
The curcumin chemical in turmeric has shown promise destroying neuroblastoma tumour cells.

Could a turmeric extract help to treat pancreatic cancer?
Medical News Today, August 2017
A common obstacle in the treatment of pancreatic cancer is drug resistance. However, new research has shown that curcumin - a compound that can be found in turmeric - can help to overcome the resistance to chemotherapy. Curcumin is the active compound found in plants such as turmeric, and more and more studies have been pointing to the therapeutic potential of the compound for various conditions, ranging from cancer to diabetes. Preclinical studies have suggested that the compound has various antioxidant, neuroprotective, anti-inflammatory, and anticarcinogenic properties. "By treating certain cells with small doses of curcumin, we were able to reverse the pathways that lead to chemoresistance," says Dr. Goel.   "This is an important breakthrough that could lead to better prognosis and longer lives for patients with chemoresistant pancreatic cancer." Previous studies have shown that curcumin has preventative benefits, but to the authors' knowledge, this is the first study that shows the beneficial effect of the plant extract in combination with chemotherapy and its advantages in overcoming drug resistance.

Baylor Scott & White Research Institute Shows Curcumin Protects Against Chemoresistant Pancreatic Cancer
Healthcare Magazine, August 2017
Baylor Scott & White Research Institute scientists found curcumin, a plant-based medicinal compound, can help overcome chemotherapy resistance in pancreatic ductal adenocarcinoma, the country’s fourth leading cause of cancer-related deaths.  According to researchers, resistance to chemotherapeutic drugs is a major challenge for PDAC patients. Initially, patients may respond to chemotherapy but, as cancer stem cells form, patients’ bodies may become immune to chemotherapy drugs. The Baylor Scott & White study stated curcumin can act as an adjunct to chemotherapy to battle this.  “By treating certain cells with small doses of curcumin, we were able to reverse the pathways that lead to chemoresistance,” Dr. Ajay Goel, director of gastrointestinal research and translational genomics and oncology at Baylor Scott & White Research Institute, said in a statement. “This is an important breakthrough that could lead to better prognosis and longer lives for patients with chemoresistant pancreatic cancer.”  Goel said his team had identified two key players in regulating drug resistance. Researchers found that when pancreatic cancer cells were treated with curcumin, the natural compound inhibited pathways associated with chemotherapy drug resistance—increasing reception to first-line drug therapy. Researchers also found curcumin can prevent the formation of spheroids, in turn reducing tumor growth and recurrence.  Currently, Goel and his research team are continuing to explore the benefits of curcumin. There are clinical trials underway studying the role of curcumin in cervical, breast, and colorectal cancers.

Curcumin Compound in Turmeric May be Used to Help Fight Cancer in Children: Scientists
NDTV.com, August 2017
A team of scientists from the United States of America have found that a bioactive compound in turmeric known as curcumin can also cure cancer in children. Neuroblastoma is one of the most common cancers in children below the age of five years. The cancer starts in early nerve cells and commonly forms in the tissue of the adrenal glands, near the kidneys. It is also associated with developmental delays, hearing loss and other disabilities.

Turmeric can be used to fight cancer in children, find US scientists
Economic Times, August 2017
Researchers at Nemours Children's Hospital and the University of Central Florida (UCF) have recently found that the nanoparticles loaded with curcumin can offer a novel treatment to target and destroy neuroblastoma tumor cells.

Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation.
PubMed, August 2017
Studies on proliferation, antioxidant activity and scratch wound healing carried out in human keratinocyte cells revealed that HA-conjugated curcumin treatment enhanced cell proliferation, decreased oxidative damage induced by H2O2 and also improved migration of cells in scratch wounds as compared to treatment with native curcumin. HA conjugated curcumin exhibited bactericidal activity in dark and phototoxicity when irradiated with blue light against antibiotic resistant bacteria. Furthermore, wound healing efficacy studied in diabetic mice demonstrated that topical application of the conjugate on wounds led to better healing as compared to treatment with HA-free curcumin and HA alone. These results suggest that HA conjugation is a promising formulation of curcumin for enhancing its healing efficacy.

Researchers Show Curcumin Protects Against Chemoresistant Pancreatic Cancer
NewsWise.com August 2017
Curcumin is known for its powerful anti-inflammatory and antioxidant benefits, but a new study by researchers at Baylor Scott & White Research Institute reveals an additional benefit: its potential to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC), a common but aggressive form of cancer in the pancreas. The study, “Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression,” recently was published in Carcinogenesis, an integrative cancer research journal. Previous research demonstrated the advantages of taking curcumin preventatively, but this is the first study of its kind to demonstrate benefits of curcumin as an adjunct to chemotherapy. Resistance to chemotherapeutic drugs is a major challenge in caring for patients with PDAC, the fourth leading cause of cancer-related U.S. deaths. Patients may respond to chemotherapy initially, but as cancer stem cells form, the body can develop drug resistance. Now, researchers have developed an improved understanding of the molecular events underlying the development of pancreatic stem cells and the role that curcumin—the main component of turmeric—plays in overcoming resistance to vital chemotherapy drugs.

Curry spice helped woman, 67, to beat blood cancer
Metro, August 2017
Dieneke Ferguson, 67, thought she had exhausted all options available after undergoing three rounds of chemotherapy and four stem cell transplants as she battled myeloma. However, she then turned to a product called curcumin, which is an ingredient of the spice turmeric, and her recovery was so incredible it has been featured in the British Medical Journal. Although curcumin features in kitchen turmeric, it only makes up around 2%, so Dieneke takes the ingredient in tablet form so she can get 8g a day. After five years of taking the tablet, that she heard about on a cancer support group, her cancer cell count is negligible.

The Benefits Turmeric Has on Your Skin
The Weekly Challenger, August 2017
Scientific studies as recent as 2017 preach the anti-inflammatory and wound-healing properties of turmeric, due to the curcumin inside the plant. Other studies have found that turmeric can help reduce skin damage, including damage due to sun exposure, pollution, smoking, aging, and acne.

How curry spice helped a dying woman beat cancer: Sufferer, 67, turned to kitchen cupboard staple turmeric after five years of failed treatment
Mail Online, August 2017
How curry spice helped a dying woman beat cancer: Sufferer, 67, turned to kitchen cupboard staple turmeric after five years of failed treatment. Dieneke Ferguson was diagnosed with the blood cancer myeloma in 2007 and underwent three rounds of chemotherapy as well as four stem cell transplants. She tried Curcumin, a component of turmeric, and five years on, her cancer cell count is negligible, with her recovery featuring in the British Medical Journal.  Curcumin has been linked to a host of benefits, including for heart disease.

5 Foods That Help Fight Cancer
The Quint, August 2017
Curcumin (turmeric extract) works brilliantly with cancer patients and balances the side effects of chemo by boosting immunity. Its highly anti-microbial and anti-inflammatory and that helps because cancer is an inflammatory disease.

Synergistic Interplay between Curcumin and Polyphenol-Rich Foods in the Mediterranean Diet: Therapeutic Prospects for Neurofibromatosis 1 Patients
Nutrients, August 2017
After six months, patients adopting a traditional MedDiet enriched with 1200 mg curcumin per day presented a significant reduction in the number and volume of cutaneous neurofibromas; these results were confirmed in subsequent evaluations. Notably, in one patient, a large cranial plexiform neurofibroma exhibited a reduction in volume (28%) confirmed by Magnetic Resonance Imaging. We hypothesize that the combination of a polyphenol-rich Mediterranean diet and curcumin was responsible for the beneficial effect observed on NF1. This is, to the best of our knowledge, the first experience with curcumin supplementation in NF1 patients. Our report suggests that an integrated nutritional approach may effectively aid in the management of NF1.

The best immune system-boosting foods
Coach, August 2017
A component of turmeric called curcumin, which gives the spice its orange-yellow colour, has been shown to have a potent stimulatory effect on the immune system. A study carried out by American and Chinese researchers last year found the consumption of curcumin resulted in the body producing more white blood cells, which then removed a tuberculosis causing bacteria from infected cells.

Family Living Focus: Turmeric
Lancaster Farming, August 2017
Curcumin, the active substance in turmeric, is a powerful antioxidant. Antioxidants aid against cell damage.  Curcumin lowers the level of two enzymes in the body that cause inflammation.  Curcumin stops platelets from clumping together to form blood clots.  Curcumin has been found to reduce the symptoms of bloating and gas in people suffering with indigestion.

Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer
Journal of Cellular Biochemistry, August 2017
The effect of curcumin on inhibiting cancer has been recognized, but the mechanism remains elusive. This study tests a hypothesis that administration of curcumin down regulates Tregs in lung cancer (LC) patients. In this study, a group of LC patients was treated with curcumin. The peripheral Tregs and T helper (Th) 1 cells were analyzed by flow cytometry. The mechanism by which curcumin regulated the Tregs was observed by cell culture approaches. The results showed that the frequency of peripheral Treg was markedly higher in LC patients than that in healthy subjects, which was suppressed after treating with curcumin for 2 weeks. The peripheral Th1 cells were increased in LC patients after the curcumin therapy. The data of the in vitro experiments showed that curcumin converted the LC patient-isolated Tregs to Th1 cells via repressing the gene transcription of forkhead protein-3 and increasing the expression of interferon-γ. In conclusion, curcumin can convert LC patient-isolated Tregs to Th1 cells. The results suggest that curcumin may improve the antitumor immunity by regulating the tumor specific immune tolerance.

Compounds in Apples, Grapes and Other Plant Foods Stop Prostate Cancer in Mice, Study Shows
Prostate Cancer News, July 2017
Researchers tested 142 natural compounds in food for prostate-cancer-fighting properties. They discovered that combinations of ursolic acid, resveratrol and curcumin stopped the disease. Ursolic acid is found in apple peels and the herb rosemary, resveratrol in red grapes and berries, and curcumin in the spice turmeric.  The study, “Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism,” was published in the journal npj Precision Oncology.  To start with, the University of Texas researchers tested the compounds on prostate cancer cells in a lab. They evaluated the substances alone and in combinations.  When the team discovered that ursolic acid, resveratrol and curcumin might inhibit prostate cancer growth, they tested all possible combinations of the compounds in mice with prostate cancer. Some combinations prevented tumor growth in the animals, with no toxic effects.  Scientists already know that chemicals in apple peels, turmeric and green tea reduce inflammation, a risk factor for cancer because it damages normal cells.  The researchers also wanted to know how the compounds inhibited tumor growth. They studied metabolic pathways, or chemical transformations needed to nourish cancer cells.  They found that ursolic acid, combined with either resveratrol or curcumin, kept cancer cells from consuming glutamine, a compound the cells need to grow. Denying the cells glutamine starved them.

Natural Compounds in Ordinary Foods Beat Prostate Cancer
News Max, July 2017
They first tested 142 natural compounds on mouse and human cell lines to see which inhibited prostate cancer cell growth when administered alone or in combination with another nutrient. The most promising active ingredients were then tested on model animals: ursolic acid, a waxy natural chemical found in apple peels and rosemary; curcumin, the bright yellow plant compound in turmeric; and resveratrol, found in red grapes and berries.,,The found that when combined with either curcumin or resveratrol, ursolic acid prevented the uptake of glutamine, a nutrient necessary for cancer growth.,,"These nutrients have potential anti-cancer properties and are readily available," says Stafano Tiziani. Combinations of the nutrients, he says, "have a better effect on prostate cancer than existing drugs.,,"The beauty of this study is that we were able to inhibit tumor growth in mice without toxicity," Tiziani said.,,The study was published in Precision Oncology.

Pre-treatment with curcumin - a safe herbal compound derived from turmeric – makes cancer stem cells sensitive to radiation therapy.
Down To Earth, July 2017
The study builds upon earlier findings that pre-treatment with curcumin - a safe herbal compound derived from turmeric – makes cancer stem cells sensitive to radiation therapy. It has found that combined effect of curcumin and exposure to radiation was markedly more effective in lowering AP-1 levels thereby rendering cells unviable for growth and replication. When treated with radiation alone, there was delayed but increased rate of proliferation and tumor formation.  The mechanism of curcumin-induced inhibition lends credibility to AP-1 as a drug target and therapeutic utility of curcumin for radio-sensitization of cervical cancer stem cells for better treatment outcomes.

Natural Ways to Lower Your Cholesterol
FitCommerce.com July 2017
Turmeric, the spicy yellow ingredient found in Indian food, contains the active ingredient, curcumin. Recent research suggests that curcumin may reduce cholesterol by interfering with intestinal cholesterol uptake, increasing the conversion of cholesterol into bile acids, and increasing the excretion of bile acids. Curcumin has powerful antioxidant and anti-inflammatory properties and may help prevent the oxidation of LDL cholesterol to a more dangerous form that is more likely to end up in your arteries.

Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats
Experimental and Therapeutic Medicine, July 2017
The results showed that curcumin significantly decreased serum amylase, Cr and BUN levels, and alleviated pancreatic and renal histological changes in SAP rats. Furthermore, curcumin markedly decreased serum TNF‑α and IL‑6 levels and downregulated renal protein levels of JAK2/STAT3 pathway components. These results proved that curcumin ameliorates acute renal injury in a rat model of SAP. The molecular mechanism of its effect may be associated with the suppression of the JAK2/STAT3 pathway to reduce TNF‑α and IL‑6 levels in SAP‑induced acute renal injury. Therefore, the findings of the present study revealed the potential use of curcumin for the prevention and treatment of SAP and the associated renal injury.

Prostate Cancer Cells Can Be Treated With Natural Compounds Present In Apple, Red Grape & Turmeric
The Science Times, July 2017
The researchers performed the tests of the compounds individually and also in combination. They identified three key compounds that played effectively in halting the growth of the prostate cancer cells. The three effective compounds are curcumin, ursolic and resveratrol.  A bright yellow curcumin is a natural compound present in turmeric, and ursolic acid can be found in the apple peel. Another important natural compound resveratrol is present in berries and red grapes. The researchers combined the ursolic acid with either resveratrol or curcumin and tested it in the mice with induced prostate cancer. They noticed that the compounds stopped the necessary uptake of the important amino acid glutamine by the prostate cancer cells.  The uptake of this amino acid helped the prostate cancer cells to grow. Now the prevention of the glutamine's uptake forced the cells to starve. This starvation ultimately led to the death of the prostate cancer cells and simultaneously halted the growth of the tumor in the mice.  One important fact is natural compounds curcumin, resveratrol, and ursolic acid caused no toxic effects on mice. The researchers found that the concentrations of the natural compounds in the mice were higher than they are normally present and consumed through the diet. However, the findings of the study have indicated promising outcome to prevent and treat the prostate cancer cells.

Life-Changing Benefits Of Turmeric
Elite Daily, July 2017
 Studies show that, in India, diagnoses of Alzheimer's disease are pretty low, and it appears to be due to turmeric's major role in the Indian diet. Curcumin helps to improve working memory, as well as attention span and mood in elderly adults.  According to a 2014 study, 60 healthy adults showed significantly improved performance on attention and working memory tasks only one hour after receiving a single dose of 400 mg of curcumin, compared with those who received a placebo. Curcumin can kill damaged cells while still leaving other cells healthy and intact, unlike chemotherapy. According to GreenMedInfo, turmeric reduces post-bypass heart risk by 56 percent.  Not only that, but the effects it has on heart health are similar to the effects that aerobic exercise has on heart health, and it improves vascular function in post-menopausal women. Curcumin can possibly be just as effective as an antidepressant.Its work with depression is related to its anti-inflammatory properties because people with depression have greater inflammation and oxidative stress, which can affect all major organs in the body, including the brain, according to Psychiatry Advisor.

Apples and Curry May Starve Prostate Cancer Cells
Vital Updates, July 2017
The study authors discovered cancer-limiting effects with curcumin, which is found in the “wonder spice” turmeric, as well.  “These nutrients have potential anti-cancer properties and are readily available,” said corresponding author Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at University of Texas at Austin. One of the most important findings that the researchers uncovered was how chemical combinations could limit glutamine metabolism in cancer cells, which need the substance to survive. Specifically, the researchers found that combining ursolic acid with resveratrol or curcumen made the biggest impact.

Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells
PLoS One, July 2017
The mechanisms by which curcumin promoted cell death in these cells were associated with cell cycle arrest, increased reactive oxygen species, autophagy and the Unfolded Protein Response. Furthermore, the upregulation of ER stress was measured using key indicators of ER stress: Glucose-Regulated Protein 78, Inositol-Requiring Enzyme 1 alpha, Protein Disulfide isomerase and Calreticulin. Chronic ER stress induction was concomitant with the upregulation of pro-apoptotic markers (caspases 3,9,12) and Poly (ADP-ribose) polymerase. The downregulated proteins include anti-apoptotic and anti-tumor markers, supporting their curcumin-induced pro-apoptotic role in prostate cancer cells. Taken together, these data suggest that curcumin may serve as a promising anticancer agent by inducing a chronic ER stress mediated cell death and activation of cell cycle arrest, UPR, autophagy and oxidative stress responses.

Relieve Pain Naturally
The Alternative Daily, July 2017
Curcumin is now one of the most effective anti-inflammatory agents known to man, and you’ll see curcumin supplements on most health store shelves across the globe. Ancient civilizations came to refer turmeric, and hence it’s active ingredient curcumin, as an almost holy plant, in large part because of it’s amazing healing powers.  Curcumin works by regulating cytokines, proteins and enzymes that are linked to inflammation. This has lead many scientists to conclude that curcumin may be one of the most effective ways to treat chronic neurodegenerative, cardiovascular, metabolic and neoplastic diseases.

Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
Science Direct, July 2017
Curcuminoids supplementation can reduce serum levels of atherogenic lipid indices including non-HDL-C and Lp(a). Therefore, curcuminoids supplementation could contribute to a reduced risk of cardiovascular events in dyslipidemic patients with T2D.

Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's disease: protecting spatial learning and memory
Journal of Neurorestoratology, July 2017
Curcumin relieved spatial learning and memory deficits, hippocampus neuronal apoptosis, and reduced JNK-3 and p-JNK-3 levels (all P<0.05). In conclusion, curcumin may inhibit JNK-3 phosphorylation to protect against hippocampal neuron apoptosis after Aβ injection.

Topical Curcumin for Precancer Cervical Lesions
ClinicalTrials.gov July 2017
The purpose of this study is to see if curcumin can reverse a cervical precancerous state by looking at people who have the condition and intervening with a study drug or placebo (an inactive drug), prior to planned therapeutic loop electrosurgical excision procedure (LEEP) which is a treatment procedure for removing cervical cancer.

Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A549
Oncology Letters, July 2017
The anticancer effects of curcumin on A549 cells can be reduced using autophagy inhibitors. This suggests a possible cancer therapeutic application of curcumin through the activation of autophagy. These findings have improved the understanding of the mechanism underlying the anticancer property of curcumin.

Food Derived Compounds Block Prostate Cancer Growth
Specialty Pharmacy Times, July 2017
 The investigators identified ursolic acid, a natural chemical found in apple peels and rosemary; curcumin, a compound in turmeric; and resveratrol, a natural compound in red grapes or berries, as the most promising active ingredients and tested them on animal models.   “These nutrients have potential anti-cancer properties and are readily available,” Tiziani said. “We only need to increase concentration beyond levels found in a healthy diet for an effect on prostate cancer cells.”   The study also showed that combining ursolic acid with either curcumin or resveratrol can prevent cancer cells from accessing crucial nutrients needed to survive. In other words, through nutrients commonly found in the human diet, the compounds can block the uptake of glutamine, which prostate cancer cells need to grow.

Turmeric And Ginger Make My Top Local “Superfood”
Longevity, July 2017
There is literally no nutrient more effective than curcumin at promoting a healthy inflammatory response in your brain, heart and body. Multiple studies say that the spice naturally detoxes the body and supports, pain-free joints, balanced moods and strong immune systems. Curcumin even improves metabolic function and reduces the risk of plaque buildup in the arteries of type-2 diabetes patients. Lastly it acts as an anti-diabetic and antioxidant in patients with type-1 diabetes. FYI, studies even say that it’s just as effective as over-the-counter anti-inflammatory medications. Moreover that the spice may also be helpful in treating osteoarthritis, viral and bacterial infections, stomach ulcers, cancer and other conditions. And because of its antioxidant properties its even being called “the natural remedy of the century.”

Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis
The American Society for Biochemistry and Molecular Biology, July 2017
This approach revealed that a curcumin-based intervention shifts the oncogenic RAS-induced MEK/ERK pro-proliferative pathway toward p38MAPK/JNK1 pro-death signaling.

Curcumin pretreatment protects against PM2.5‑induced oxidized low‑density lipoprotein‑mediated oxidative stress and inflammation in human microvascular endothelial cells
Molecular Medicine Reports, July 2017
Curcumin induced NF‑κB, cell adhesion molecule 1 and vascular cell adhesion protein 1 expression. Thus, curcumin treatment may reduce PM2.5‑induced oxidative stress and inflammation in HMEC‑1. In summary, it was indicated that the effects of PM2.5 are associated with oxLDL via the NF‑κB signaling pathway, thereby inducing PM2.5 mediated oxidative and inflammatory responses. The results also suggested that curcumin may be able to reduce the oxidative and inflammatory effects of PM2.5 in HMEC‑1.

Curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through induction of nuclear factor erythroid‑2‑related factor 2 and heme oxygenase‑1
Experimental and Therapeutic Medicine, July 2017
Treatment with curcumin effectively reduced the brain injury score, increased myelin basic protein (MBP) expression and increased the quantity of neuronal cells in neonatal rats with hypoxic‑ischemic brain injury. Furthermore, treatment with curcumin significantly attenuated the changes in SOD activity and MDA levels and suppressed the iNOS protein expression induced in neonatal rats by hypoxic‑ischemic brain injury. Treatment with curcumin significantly increased Nrf2 and HO‑1 expression in the neonatal rats with hypoxic‑ischemic brain injury. The present study indicated that curcumin attenuates hypoxic‑ischemic brain injury in neonatal rats through the induction of Nrf2 and HO‑1.

Turmeric and Curcumin: A Primer
Psychology Today, June 2017
According to lab studies, there is evidence that turmeric curcumin may help both prevent and treat certain cancers, including: prostate, breast, skin, lung, pancreatic, and colon cancers.[1,14] It is also useful in the treatment of the symptoms and inflammation associated with chemotherapy for the treatment of cancer. (Goel, 2017) There are over 2,000 published studies on the subject, and the general centire onclusion is that curcumin supplementation may be beneficial for both cancer prevention and better treatment results.[14] In this sort of situation, taking pure curcumin extract instead of turmeric is preferred, because of the dosage requirements for maximum benefit. Many of these studies in the laboratory have shown that curcumin can actually stop cancer cells from dividing.[14] Cancer occurs when the DNA in cells get damaged, which causes them to divide uncontrollably, forming tumors. These can spread across your body if left untreated.[15] Keeping these cells from dividing helps stop cancer development in its tracks. Curcumin has also been shown to trigger programmed cell death, or apoptosis. This is a healthy and natural way for our bodies to eliminate damaged cells, and it’s helpful for getting rid of cancer cells. In many ways, curcumin is a good adjunct to chemotherapy. There have been no reported toxicities associated with curcumin consumption in this setting, and significant benefit. (Goel, 2017) For many people, this is an extremely attractive option when dealing with cancer treatment. Medicinal Uses for Turmeric Curcumin But as impressive as the results are in those undergoing cancer treatment and chemotherapy; the medicinal uses of turmeric are broad. It has been shown to alleviate pain and improve knee functioning in patients with osteoarthritis.[1] Many people suffer from arthritis, which involves inflammation of the joints. It can cause not only pain and swelling, but also limited mobility.[16] A study of 107 participants found that curcumin had roughly the same effect on patients as ibuprofen.[17] Turmeric is also able to assist in maintaining a healthy digestive tract as well. Its medicinal properties help regulate healthy digestion. Turmeric is especially effective against diarrhea from many causes, including infection, or inflammatory diseases like irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD) like Crohn’s disease or ulcerative colitis. One study on turmeric’s effect on ulcerative colitis showed that patients who consumed turmeric curcumin had significantly lower relapse rates than patients who did not consume it. This was a double-blind placebo-controlled study, which is the gold standard of clinical study design and methods; and one of the most reliable scientific ways to gather scientifically valid information.[24] Another sign of turmeric curcumin’s major health benefits is the fact that rural India’s population houses the lowest rates of Alzheimer’s disease (AD) in the entire world.[32] Adults in India are 4.4 times less likely to develop AD than comparably aged cohorts in other industrialized countries. Epidemiological and animal studies suggest an important role for turmeric and curcumin in potential prevention and treatment of neurodegenerative diseases like Alzheimer’s disease. (Ringman, Frautschy, Cole, Masterman, & Cummings, 2005, ) (Sikora, Scapagnini, & Barbagallo, 2010)

Curcumin induces apoptotic cell death in human pancreatic cancer cells
Oncology Letters, June 2017
The natural compound curcumin has previously been reported to inhibit pancreatic cancer cell growth. miR‑340 was identified to be significantly upregulated following curcumin treatment. In addition, treatment with curcumin or miR‑340 induced pancreatic cancer cell apoptosis, whereas silencing endogenous miR‑340 significantly inhibited the proapoptotic effect of curcumin. Furthermore, curcumin treatment significantly reduced XIAP expression, an effect that was rescued by treatment with anti‑miR‑340. The results of the present study suggest that the miR‑340/XIAP signaling pathway is a downstream target of curcumin that mediates its proapoptotic effects on pancreatic cancer cells. This may provide the basis for novel treatment strategies for patients with pancreatic cancer.

Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells
Oncology Reports, June 2017
Curcumin possesses an anticancer effect against a wide assortment of tumors with selective cytotoxicity for tumor cells. Our results demonstrated that curcumin inhibited the viabilities of gastric cancer cell lines BGC-823, SGC-7901 and MKN-28 in both a time- and dose-dependent manner. In addition, curcumin treatment induced gastric cancer cell apoptosis in a dose‑responsive manner. Western blotting of apoptosis‑related proteins further confirmed the pro-apoptotic potential of curcumin. After exposure to curcumin, a robust induction of autophagy was observed in gastric cancer cells, which was characterized by the formation of acidic vesicular organelles (AVOs), conversion of LC3-I to LC3-II and an increase in the levels of autophagy‑related proteins. Activation of the PI3K/Akt/mTOR signaling pathway was suppressed in gastric cancer cells with curcumin treatment. Collectively, our findings provide new evidence that curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells in vitro. Autophagy inhibitor treatment may provide a novel and effective strategy for improving the anticancer effect of curcumin against gastric cancer.

Turmeric (Curcumin),The Healing Root
blastingnews.com June 2017
Curcumin or curcuma longa, is a powerful antioxidant, adaptogen, antiviral, antibacterial, anti inflammatory, anti carcinogen and contains many beneficial vitamins and minerals including zinc, protein, niacin, fibre, vitamin C, vitamin E, vitamin K, iron and magnesium. Turmeric according to over 6000 #Peer Reviewed scientific studies, is beneficial for all sorts of ailments including inflammation, skin disorders, gastrointestinal disorders such as IBS, arthritis, viral infections, nausea, hormonal imbalances, obesity, hypertension, glaucoma, Helicobacter pylori, diabetes, high cholesterol, cancer and depression.

Antitumor effects of curcumin in human bladder cancer in vitro
Oncology Letters, June 2017
Curcumin was identified to decrease the growth of T24 and 5637 cells in a dose‑ and time‑dependent manner. The present study confirmed that curcumin is able to inhibit cell migration and promote apoptosis of bladder cancer through suppression of matrix metalloproteinase signaling pathways in vitro. The anticancer effects of curcumin on bladder cancer cells may benefit clinical practice in the future.

JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells
Experimental and Therapeutic Medicine, June 2017
In the current study, it was determined that curcumin was able to significantly induce apoptosis, and lead to autophagy in MG63 cells. Notably, inhibition of apoptosis enhanced curcumin‑induced autophagy due to upregulation of the c‑Jun N‑terminal kinase (JNK) signaling pathway. This finding was confirmed by the use of JNK‑specific inhibitor, SP600125. Furthermore, our data showed that curcumin‑induced apoptosis was increased when autophagy was completely inhibited by 3‑methyladenine in MG63 cells. These results suggest that autophagy may have an important role in resistance to apoptosis when MG63 cells are incubated with curcumin. Thus, these results provide important insights into the interaction between apoptosis and autophagy in osteosarcoma cells and clinical treatment strategies using curcumin.

Compound in turmeric found to suppress viruses, including hepatitis, herpes, chikungunya, influenza-A, HIV and HPV
Natural News, June 2017
The turmeric compound curcumin was found to effectively suppress a large number of viruses, recent studies showed. The compound was previously known to defer cancer growth, resolve Lichen Panus, reduce type-2 diabetes and prevent Alzheimer’s disease and dementia onset. However, a new article published in GreenMedInfo.com listed several other studies indicating that the compound was able to inhibit the growth of a plethora of viruses including zika virus, hepatitis, herpes, chikungunya virus, influenza-A, HIV and HPV. Curcumin was found to affect the virus; ability to bind with other cells. Another study published in the journal Gut showed that curcumin hindered the hepatitis C virus from entering the human liver cells. According to the researchers, this effect proved especially beneficial — as exposure to the HCV virus caused severe liver disease and was known to affect more than 160 million people around the world. Membrane fluidity experiments indicated that curcumin affected the fluidity of the HCV envelope resulting in impairment of viral binding and fusion. Curcumin has also been found to inhibit cell-to-cell transmission and to be effective in combination with other antiviral agents," the researchers concluded. Turmeric compound impedes more viruses Curcumin was also known to suppress the influenza-A virus in a number of studies. Researchers at the Graduate Institute of Microbiology and Public Health at the National Chung Hsing University in Taiwan found that the turmeric compound interfered with the virus' haemagglutination activity by blocking its ability to bind with red blood cells in patients. In addition, a study published in the Italian Journal of Biochemistry revealed that curcumin prompted hemeoxygenase-1 gene stimulation in the hippocampus of the brain. In turn, this activation triggered the production of bilirubin, a potent antioxidant essential for the immune system’s health. According to researchers at the Michigan State University, curcumin inhibited the herpes virus from spreading by affecting its early gene expression. “Curcumin is a potent compound with various biological properties. We have shown that curcumin significantly affects HSV-1 IE gene expression which thereby diminishes the ability of the virus to launch the lytic infectious cycle,” the researchers wrote. A study published in the Asia Pacific Journal of Cancer Prevention also found that curcumin was able to clear human papillomavirus in women. As part of the study, researchers at the Chittaranjan National Cancer Institute in India examined 287 HPV-positive women. The experts noted that women who were given curcumin-based treatments had HPV clearance rates between 81 percent and 87 percent.

Effective Natural Pain Relief for Fibromyalgia
nationalpainreport.com June 2017
More recently researchers have called curcumin, the active ingredient in turmeric, the “herbal ibuprofen.” [https://www.ncbi.nlm.nih.gov/m/pubmed/7390600/] One study found that curcumin was actually more effective at reducing pain and swelling in arthritic joints than anti-inflammatory medications. [http://onlinelibrary.wiley.com/doi/10.1002/ptr.4639/abstract;jsessionid=A768F9AF39A7EE0BC525EC80EC1A6861.f04t04]

Curcumin touted for metabolic benefits in people with fatty liver disease: RCT data
Drug Research, June 2017
Curcumin is a dietary polyphenol with lipid-modifying, antioxidant and anti-inflammatory properties. Supplementation with curcumin was associated with a reduction in body mass index (−0.99±1.25 vs.  − 0.15±1.31 in the curcumin and placebo groups, respectively; p=0.003) and waist circumference (−1.74±2.58 vs. −0.23±3.49 in the curcumin and placebo groups, respectively; p=0.024). Ultrasonographic findings were improved in 75.0% of subjects in the curcumin group, while the rate of improvement in the control group was 4.7% (p<0.001). Serum levels of aspartate aminotransferase and alanine aminotransferase were reduced by the end of trial in the curcumin group (p<0.001) but elevated in the control group (p<0.001). Curcumin was safe and well tolerated during the course of trial. Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.

Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage
Nutrients, June 2017
Curcumin, the active substance of Curcuma longa which is attributed most of the beneficial properties of turmeric, is chemically classified among the polyphenols. The many beneficial properties attributed to curcumin, as antioxidant, anti-inflammatory, anti-infective, anti-tumor, and preventive agent, are closely correlated with each other and could be associated with the ability to modulate the molecules involved in inflammation, programmed cell death, and morphology.In the present work, we demonstrated that pre-treatment with curcumin is able to reduce the levels of apoptosis in intestinal epithelial cells exposed to IFNγ.

Can turmeric help manage diabetes? What the evidence says
WXYZ Detroit, June 2017
Research focuses on the main component of turmeric called curcumin. A review of 13 years of research suggest curcumin may help in different ways. Adding it to your diet may reduce your chance of developing diabetes as curcumin appears to improve the cells that create insulin in the pancreas. Taking curcumin orally may reduce blood sugar levels, however more research is needed in humans. Other studies have shown those with prediabetes may not develop full diabetes when taking curcumin in capsule form.Taking curcumin may also help to prevent diabetic-related nerve damage, prevent diabetic cataracts and kidney disease.

Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
Nature.com June 2017
Curcumin exerts anti-inflammatory effects in DSS-induced colitis

Turmeric: From humble root to golden goddess
Vancouver Sun, June 2017
The active ingredient, curcumin has also been investigated by western science as a cancer-fighting agent. Studies have shown that curcumin is an anti-cancer agent and an anti-inflammatory. It inhibits an enzyme called COX-2 that is activated in various inflammation cascades. It works similarly to non-steroidal anti-inflammatory drugs.

Anticancer effect of curcumin inhibits cell growth in breast cancer cell
Oncology Letters, May 2017
Curcumin is a polyphenol extracted from turmeric, which that belongs to the Zingiberaceae family. Curcumin has numerous effects, including anti-inflammatory, antitumor, anti‑oxidative and antimicrobial effects. Curcumin inhibited cell viability and induced cytotoxicity of MCF‑7 cells in a concentration‑ and time‑dependent manner, by inducing apoptosis and increasing caspase‑3/9 activities. In addition, curcumin downregulated miR‑21 expression in MCF‑7 cells by upregulating the PTEN/Ak
t signaling pathway. The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth.

How Turmeric Shows Great Promise as a Natural Remedy for the Prevention and Healing of Symptoms of Type 2 Diabetes
EmaxHealth, May 2017
The science on curcumin, an Indian spice and anti-inflammatory has shown promise in reducing and even preventing complication of diabetes with it's effects on insulin resistance and by regulating blood sugar. The systematic review published in the peer-reviewed journal, Evidence-Based Complementary and Alternative Medicine looked at curcumin and its effect on diabetes in the prevention and treatment of diabetes and its associated disorders. The review concluded that curcumin could favorably affect most of the leading aspects of diabetes, including insulin resistance, hyperglycemia, hyperlipidemia, or high concentrations of lipids in the blood, and islet apoptosis and necrosis, or organ failure. In addition, curcumin showed promise in preventing the injurious complications of diabetes.

Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism
Complementary and Alternative Medicine, May 2017
Curcumin plays a significant therapeutic role in attenuating brain damage that has been induced by prenatal VPA exposure in rats; however, its therapeutic role as a dietary supplement still must be certified for use in humans.

Curcumin: A naturally occurring modulator of adipokines in diabetes
Journal of Cellular Biochemistry, May 2017
Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes.

This Could Be The Greatest Spice For Men's Health
Huffingtonpost.com May 2017
Curcumin extracts have been shown to reduce the pain and improve function in knee osteoarthritis “with an efficiency equivalent to ibuprofen, but with fewer gastrointestinal side effects.” Combining curcumin and Boswellia serrata also has been shown to be more effective than the COX-2 inhibitor celecoxib in the treatment of osteoarthritis.A number of studies have found that turmeric/curcumin is effective in reducing depression, especially mild cases. One study noted that patients with major depressive disorder who took curcumin fared just as well as their peers who took Prozac (fluoxetine). A more recent meta-analysis of six clinical trials reported that curcumin “appears to be safe, well-tolerated, and efficacious among depressed patients.” Curcumin has been shown to improve glucose tolerance in animal research as well as significantly lower hemoglobin A1c in patients with type 2 diabetes. Free-radical fighting antioxidants called curcuminoids are abundant in turmeric. Curcumin is the most prominent of these polyphenols. In addition to helping destroy disease-causing free radicals, curcuminoids also facilitate the activity of antioxidant enzymes (e.g., catalase, superoxide dismutase). Antioxidants can help slow the aging process, protect against chronic disease (including cancer and heart disease), reduce oxidative stress, and fighting inflammation.

Healing The Body, Naturally
Elle Magazine, May 2017
There is good research to support the ability of curcumin to reduce cellular damage and risk of chronic disease; decrease pain and inflammation (effects have been shown to be similar to paracetamol); [and] it may reduce the risk of heart disease. Curcumin intake is also associated with a decreased risk of colon cancer and reduced symptoms associated with ulcerative colitis.

Curcumin sensitizes prostate cancer cells to radiation
J Drug Target, May 2017
Curcumin has been reported as a radiosensitizer in prostate cancer. Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.

Turmeric: The Golden Herb
Hamlet Hub, May 2017
Anti-inflammatory: the constituent curcumin is responsible for the anti-inflammatory action thus reducing inflammation and making it useful in the treatment of muscle pain, joint pain, arthritis, fibromyalgia, ulcerative colitis, Chrohn’s disease, rheumatoid arthritis, cancer, irritable bowel syndrome (IBS), headaches, SLE, bronchitis, autoimmune diseases, cardiovascular diseases. Anti-oxidant: curcumin can protect the DNA against breaks and oxidation which makes it useful in the treatment of different types of cancer, autoimmune diseases, cardiovascular health, protective for the body. Anti-neoplastic: curcumin has been proven to have anti-cancer properties in the body. Either as part of a treatment protocol or as preventative. Lipid modulation: curcumin has shown positive results in decreasing total plasma cholesterol levels, decreasing LDL, decreasing triglycerides and increasing HDL levels. It also helps decrease inflammation in the vessels hence improving cardiovascular health and decreasing risks. Anti-platelet: curcumin has been shown to prevent thrombus formation from platelet aggregation hence being beneficial for cardiovascular health. Anti-bacterial: curcumin has also shown effectiveness with treating infections. Anti-hepatotoxic: curcumin has been shown to stimulate Phase II detox activity in the liver helping excrete toxins out of the body.

New Prospects for Treating Malignant Mesothelioma with Curcumin
SurvivingMesothelioma.com May 2017
There is more evidence that the active ingredient in turmeric may have the power to help combat malignant mesothelioma. A new French study on curcumin finds that the compound not only slowed the growth of one of the rarest types of mesothelioma tumor cells in the laboratory but also reduced total tumor mass in lab rats in just two weeks. Curcumin, the plant polyphenol that gives turmeric its yellow hue and pungent flavor, has been the subject of numerous malignant mesothelioma studies in recent years, in part because of its powerful anti-inflammatory properties. In addition, curcumin appeared to attract cancer-fighting CD8+ T lymphocytes to the area which clustered around small residual mesothelioma tumors in the peritoneal cavity after treatment. “These data open up interesting new prospects for the therapy of sarcomatoid mesothelioma with curcumin and its derivatives,” concludes Dr. Pouliquen. Earlier this year, scientists in the Department of Experimental Medicine at the University of Rome conducted a similar experiment and that found that intraperitoneal curcumin extended survival in mice with mesothelioma. In 2015, mesothelioma researchers with Flinders University in Australia determined that curcumin had the ability to keep mesothelioma tumors from giving rise to their own new blood vessels. That study suggested that curcumin could become a supplemental treatment for certain mesothelioma patients.

Why are so many scientists studying this spice?
Stuff, May 2017
Curcumin is also an antioxidant which helps prevent free radical damage -studies have found that people with depression have greater free radical damage to brain cells. Curcumin appears to help protect brain cells - which is why other studies are looking at whether curcumin might help prevent dementia. There's a huge demand for an anti-inflammatory substance that doesn't have side effects and curcumin stands out. More than 60 studies of curcumin worldwide are looking at its potential role with a number of cancers.

Curcumin improves bone density by up to 7%, study reveals
Daily Mail, May 2017
A compound in turmeric, known as curcumin, is thought to balance out cells that remove ageing parts of bone before it is replaced, according to previous findings. Curcumin blocks rogue proteins called beta amyloid, which clump together and destroy neurons, according to researchers from Edith Cowan University, Perth. In the study 96 participants aged between 40 and 90 were given either a daily placebo or 1,500 mg of curcumin for 12 months. In tests of verbal and memory skills, those taking the dummy pill suffered a decline in mental function after just six months that was not observed in those having curcumin.

Curcumin exerts antitumor activity
OncoTargets and Therapy, May 2017
Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. Curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target. Our results identified that upregulation of miR-7 by curcumin could benefit nasopharyngeal carcinoma patients.

Curcumin, Found in Turmeric Plants, Seen to Shrink Sarcomatoid Mesothelioma Tumors in Rat Study
MesotheliomaResearchNews.com May 2017
When curcumin was administered to rats one week after the injection of tumor cells, the size of the tumors dropped dramatically by the 16th day. The researchers also found that curcumin appeared to stimulate the immune system, observing a type of white blood cell surrounding remaining tumors in rats treated with curcumin. This white blood cell, known as a CD8+ T-cell, is known to kill cancer cells under the right conditions. “In conclusion, these data open up interesting new prospects for the therapy of malignant mesothelioma with curcumin, in particular the sarcomatoid subtype,” the research team wrote. “Future studies will determine the best sequence/dose(s) of curcumin or its many derivatives to use to optimize the specific immune response directed against M5-T1 cells. A complementary approach would also be the combination of curcumin/derivatives with current chemotherapeutic agents to reduce the dose used and the associated systemic toxicity of the latter.”

Superfood focus: Healthy properties give turmeric a golden touch
The National, May 2017
The benefits are primarily due to curcumin, the active compound in turmeric that is not only responsible for its bright hue, but also a powerful antioxidant with anti-inflammatory and antibacterial qualities.

Turmeric may help ease the symptoms of Lyme disease
EmaxHealth, May 2017
The secret is turmeric’s curcumin, a plant chemical that has many healing capabilities, and has been scientifically proven to counter skin rashes, fatigue, bacterial infections and pain in joints and muscle, all of which are symptoms of Lyme disease. Research has proven that curcuminoids can improve the pain and physical function of patients suffering from knee osteoarthritis, an extremely debilitating and painful disease that is characterized by the degeneration of joint cartilage and the underlying bone causing inflammation. In an animal model study on immunologically induced fatigued mice, scientists were able to observe that oral administration of curcumin, reduced oxidative stress, increased in mobility ( mice were less tired), and also reduced abnormal sensitivity to pain. Curcumin protects skin by quenching free radicals and reducing inflammation through nuclear factor-KB inhibition. A study trying to establish the effectiveness of curcumin against 4 types of bacteria, namely Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginos, has confirmed that turmeric is effective against all the bacterias tested and the extent of bacteria killing showed an increase with dosage and incubation time.

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.
BMC Complementary and Alternative Medicine, May 2017
Resveratrol and curcumin, as natural flavones products, have good therapeutic effect in acute and chronic inflammation; on the other hand, tetramethylpyrazine (TMP) has angiogenesis and vessel protection effect as well as anti-inflammatory function. In this paper, the anti-inflammatory effect of the tetramethylpyrazine, resveratrol and curcumin (TRC) combination in acute and chronic inflammation was reported in vivo.

Curcumin Inhibits Apoptosis of Chondrocytes
Nutrients, May 2017
Osteoarthritis (OA) is an inflammatory disease of load-bearing synovial joints that is currently treated with drugs that exhibit numerous side effects and are only temporarily effective in treating pain, the main symptom of the disease. Curcumin, the principal curcuminoid and the most active component in turmeric, is a biologically active phytochemical. Evidence from several recent in vitro studies suggests that curcumin may exert a chondroprotective effect through actions such as anti-inflammatory, anti-oxidative stress, and anti-catabolic activity that are critical for mitigating OA disease pathogenesis and symptoms. Curcumin should be explored further for the prophylactic treatment of osteoarthritis in humans and companion animals.

Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells
Oncotarget, May 2017
Studies have demonstrated that curcumin exerts its tumor suppressor function in a variety of human cancers including glioma. Curcumin significantly inhibited cell growth, suppressed cell migration and invasion, induced apoptosis and cell cycle arrest in glioma cells. Curcumin exerts its antitumor activity through inhibition of Skp2 pathway. Collectively, our findings suggest that targeting Skp2 by curcumin could be a promising therapeutic approach for glioma prevention and therapy.

Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma.
Oncotarget, May 2017
The treatment of tumor-bearing rats with 1.5 mg/kg curcumin on days 7, 9, 11 and 14 after tumor challenge dramatically reduced the mean total tumor mass at day 16. .These data open up interesting new prospects for the therapy of sarcomatoid mesothelioma with curcumin.

Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts
International Journal of Molecular Medicine, April 2017
Curcumin suppress cell proliferation in the pterygium by inducing HPF apoptosis and inhibiting VEGF expression. Thus, curcumin has potential for use as a novel agent for the treatment of pterygium in the near future.

History and Origins of Turmeric
DESIblitz, April 2017
Elderly villagers in India appear to have the lowest rate of Alzheimer’s disease in the world, and researchers have speculated that the anti-inflammatory effects of curcumin may be partly responsible,” states Dr Andrew Weil.  Curcumin may kill and prevent cancer cells of the breast, bowel, stomach and skin from growing. Curcumin also acts as an antioxidant, which protects the body from free radical damage (free radicals contribute to increased cancer risk).  Curcumin can help sustain healthy blood pressure. This ultimately, promotes heart health and reduces the likelihood of developing heart disease. The spice may also prevent the clogging of arteries, which is a risk factor for strokes and heart attacks. Curcumin also seems to reduce the risk of developing diabetes among pre-diabetic individuals.

Medicinal Herbs for Cancer
Liberty Voice, April 2017
Curcumin, in turmeric, is a powerful anti-inflammatory agent. Additionally, it contains broad anti-parasitic and antimicrobial features. Turmeric has properties to support the fight against cancer by preventing cells from dividing quickly to form tumors, and prevents the development of capillaries that feed tumors. The active ingredient in turmeric, curcumin, kills diseased cells without damaging the healthy cells. It does this by removing the activation path of most diseases caused by inflammation, which is linked to cancer. Turmeric is effective in preventing cancer of the stomach, lung, colon, breast, and skin.

Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation
School of Pharmaceutical Sciences, São Paulo State University, April 2017
Treatments with mixtures of curcumin and lycopene or bixin had combined effects, decreasing biomarkers of carbohydrate and lipid disturbances (curcumin effect), increasing the HDL levels (carotenoids effects) and mitigating oxidative stress (curcumin and carotenoids effects). The combined effects also led to prevention of the LDL oxidation, thereby mitigating the cardiovascular risk in diabetes. These findings provide evidence for the beneficial effect of curcumin and carotenoid mixtures as a supplementation having antioxidant and antiatherogenic potentials, thus appearing as an interesting strategy to be studied as a complementary therapy for diabetic complications.

Proven Health Benefits of Turmeric and Dosage
Belair Daily, April 2017
Turmeric has a powerful active ingredient called curcumin that is known to be a natural antioxidant and has been used for generations as a treatment for digestive and liver problems. Now, turmeric and diabetes have been linked through several studies.

Foods that flush the body
JamaicaObserver.com April 2017
Curcumin is a component that stimulates the production of bile by the gall bladder. Bile is used by the kidneys, not just to eliminate toxins, but also to restore and revitalise liver cells that are central to the deconstruction of harmful compounds.

The science on curcumin
Mind Body Green, April 201
Curcumin is a powerful antioxidant within turmeric and the center of most of the research about turmeric. Because of the evidence of curcumin's powerful anti-inflammatory benefits, it's extracted and standardized in higher doses to be put into supplements. What's the science on curcumin? The commonality between just about all the research done on turmeric and curcumin boils down to one thing: inflammation. Inflammation is a buzzword of late and something we have talked about in functional medicine for years. Curcumin and turmeric are known for their ability to tame chronic inflammation; here's a roundup of health problems for which they seem to be beneficial: Alzheimer's Autoimmune inflammation Brain inflammation (brain fog and memory loss) Cancer Candida Cataracts Depression Diabetes Erectile dysfunction Gallbladder problems Heavy metal toxicity Inflammatory bowel disorders Insulin resistance Lupus Pneumonia Rheumatoid arthritis Viral infections Weight-loss resistance.

10 Ways Turmeric Might Be Superior To Modern Medicine
The Alternative Daily, April 2017
The active compound in turmeric — curcumin — is on par with over-the-counter anti-inflammatories, without all the harmful side effects. In one study, researchers tested stressed-out lab rats displaying depression-like symptoms along with adrenal issues, caused by a prolonged elevation in stress hormones. Surprisingly, they found that curcumin helped to alleviate negative physiological effects. “These results provide compelling evidence that the behavioral effects of curcumin in chronically stressed animals, and by extension humans, may be related to their modulating effects on the HPA axis and neurotrophin factor expressions,” wrote the authors. Several studies have found that curcumin can significantly inhibit the development and movement of cancer cells through the body. It does this by reducing the growth of new blood vessels in tumors, called angiogenesis. Curcumin may also contribute to the cancer cell death directly.

Anti-inflammatory efficacy of turmeric oil and curcumin in colitis
Nature.com April 2017
Considering that curcumin is a readily available, safe and a cost-effective botanical, there is a growing interest in exploring its clinical efficacy individually or as an adjunctive treatment for managing and/or treating UC and subsequently improving the overall quality of life for patients with this inflammatory disease. Although curcumin is a well-established anti-inflammatory agent, the exact mechanism(s) by which it attenuates inflammatory burden in diseases such as UC remains unclear. Herein, we demonstrated that curcumin exhibited significant anti-inflammatory effects in a mouse model of dextran sodium sulfate (DSS)-induced colitis.

Go for the gold with turmeric
SC Now, April 2017
Turmeric contains a phytochemical nutrient named curcumin, which is an antioxidant known for anti-inflammatory, anti-microbial and anti-cancer properties. With more than 100 clinical studies, curcumin has been shown to be active against several chronic diseases, including various types of cancers, diabetes, obesity, cardiovascular, pulmonary, neurological and autoimmune diseases, such as inflammatory bowel disease.

Rescue, April 2017
Turmeric contains Curcumin as the main active ingredient, which has antioxidant and anti-inflammatory properties. As an anti-inflammatory curcumin is powerful, matching the effectiveness of some drugs. Low level inflammation is involved in almost every chronic condition; cancer, Alzheimer’s, metabolic syndrome as examples. Curcumin actually targets the inflammatory pathway at a molecular level. In addition to protecting against free radical damage (antioxidant) and chronic inflammation (anti-inflammatory), curcumin has shown promise in treating depression and could be considered an anti-ageing supplement.

Clinical Use of Curcumin in Depression: A Meta-Analysis
Journal of the American Medical Directors Association, March 2017
Six clinical trials with a total of 377 patients were reviewed, comparing the use of curcumin to placebo. In patients with depression, the pooled standardized mean difference from baseline Hamilton Rating Scale for Depression scores (pooled standardized mean difference −0.344, 95% confidence interval −0.558 to −0.129; P = .002) support the significant clinical efficacy of curcumin in ameliorating depressive symptoms. Significant anti-anxiety effects were also reported in 3 of the trials. Notably, no adverse events were reported in any of the trials. Most trials had a generally low risk of bias, except for an open trial of curcumin and a single-blinded study.

10 Health Benefits Of Turmeric And Curcumin You Need To Know
Global Health Clinics, March 2017
Curcumin has been shown to reduce inflammation by lowering levels of two inflammation enzymes in the body. Inflammation is a complicated immunological process that takes places in the cell. Curcumin works at a cellular level to block out bioactive molecules that trigger the inflammation process common in most chronic diseases such as arthritis and gastrointestinal disorders. One of the mechanisms behind ageing and many diseases is oxidative damage. Curcumin is a potent antioxidant that can neutralize free radicals in the body helping to prevent aging and disease. It can also stimulate the body’s own antioxidant properties. Brain derived neurotrophic factor (BDNF) is a type of growth hormone that functions in the brain. Curcumin has been shown to increase neurogenesis, potentially via modulation of the hypothalamic-pituitary-adrenal (HPA) axis and by increasing (BDNF) production in the brain. Depression has been linked to reduced levels of BDNF. Studies have confirmed that curcumin, found in turmeric, has a similar effect as antidepressants on patients suffering from depression by boosting levels of BDNF. Curcumin has also been shown to boost the brains neurotransmitters serotonin and dopamine. Due to its high antioxidant and anti-inflammatory properties curcumin can lower the chance of heart diseases. Curcumin improves the lining of the blood vessels, regulate blood pressure and reduce blood clotting. One study found that curcumin is just as effective as exercise at improving blood flow to the heart. Curcumin contains anti-cancer compounds that can strengthen the body providing cancer protection. Given that curcumin is a potent anti-inflammatory, it makes sense that it could help with arthritis as it has a positive effect on joint swelling and pain-reduction. Some studies suggest that patients with rheumatoid arthritis, curcumin was even more effective than an anti-inflammatory drug.Curcumin is known for its anti-inflammatory properties that can pass through the blood/brain barrier, unlike other substances and has been shown to lead to various improvements in the pathological process of Alzheimer’s disease. Due to all of curcumins potent health benefits listed above such as reducing inflammation in the body and being a potent antioxidant curcumin provides compounds that kill off free-radicals that cause the ageing process and prevent disease.

Spice Compound Extends Mesothelioma Survival in Mice
Surviving Mesothelioma, March 2017
Curcumin has been the subject of numerous mesothelioma studies. The latest one, conducted by scientists at the Department of Experimental Medicine at the University of Rome, finds that the compound has the power to not only kill mesothelioma cells in the lab, but to also extend survival in mice infected with the asbestos cancer.

The ancient wisdom of turmeric
Lacrosse Tribune, March 2017
“Curcumin is the compound in turmeric that gives it its bright yellow hue,” says Rachael Hartley, R.D., L.D., C.D.E. It has been shown to block enzymes in the inflammatory pathways, potentially fighting inflammation at the molecular level, and it’s being actively studied for relief of swelling and pain in both osteoarthritis and rheumatoid arthritis. Curcumin is also a powerful antioxidant, and lab and animal studies have reported that curcumin inhibits cancer at multiple stages of development, although we don’t yet know how that might work in the body. The anti-inflammatory and anti-oxidant effects could help reduce heart disease risk, and this potent turmeric component also may help keep the lining of veins and arteries healthy and reduce cholesterol levels.

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
Drug Design, Development and Therapy, March 2017
Curcumin induces apoptosis and autophagy in different cancer cells. Moreover, chemical and biological experiments have evidenced that curcumin is a biologically active iron chelator and induces cytotoxicity through iron chelation. Our results indicate that curcumin induces apoptosis and protective autophagy in CRPC cells.

Turmeric’s anti-aging effects
EmaxHealth, March 2017
Recent studies have observed in animal and human trials that Turmeric’s natural chemical knows as Curcumin, (the yellow pigment from the rhizoma of Curcuma longa), exerts powerful anti-oxidant, photo-protective and anti - inflammatory activities. This leads scientists to believe that curcumin has anti-ageing effects. A review of the literature on the effects of Curcumin in the body, published by the journal of alternative medicine, found that a high dose of Curcumin is not toxic for humans. In one of the studies 25 subjects used up to 8000 mg of curcumin per day for 3 months, and five other subjects used 1125-2500 mg of curcumin, which was also found to be safe. There are three main aspects of ageing: oxidative stress, inflammation and sun damage. Experts at the Deparment of Neuroscience and Neurology in Finland, explain that during aging, adaptive immunity significantly declines, while innate immunity seems to be activated which induces a characteristic pro-inflammatory profile. The first way in which Turmeric works is by inhibiting the number of different molecules that play a role in inflammation. In 2010 an article published at Current Design, has measured the molecular targets of curcumin in the body. The researchers found that that curcumin directly affects a few major targets, such the NF-κB signaling pathways, which can in turn suppresses the pro-inflammatory state involved in the etiology of ageing and age-related diseases. Therefore, Curcumin’s anti- ageing results are compelling.

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice
Oncotarget, March 2017
Curcumin is a "multifunctional drug". Intraperitoneal administration of curcumin increased the median survival of C57BL/6 mice intraperitoneally transplanted with #40a cells and reduced the risk of developing tumors. Our findings may have important implications for the design of MM treatment using curcumin.

Turmeric is effective in treating various types of cancer
Kashmir Monitor, March 2017
Curcumin, the principal curcuminoid of turmeric, has been intensely studied as a cancer protective agent. Its potential has been tapped in head and neck cancers, breast, lung, gastro-intestinal cancer, ovarian cancer, melanoma, neurological cancers, sarcoma, leukemias and lymphoma.

Compound in Turmeric Shows Promise for Treating Mesothelioma
Mesothelioma.com, March 2017
Curcumin, a compound in the spice turmeric, has shown promise as a possible treatment for malignant mesothelioma. A recent study discovered the compound blocked intracellular degradation and activated the death of mesothelioma cells. Plus, it increased the survival of mice given the mesothelioma cell line.

Benefits of Turmeric
Verge Campus, March 2017
The compound curcumin is naturally occurring in turmeric, and it is responsible for the many benefits of the plant. However, curcumin makes up only around 3% of the make-up of turmeric by weight. For that reason, supplements are the best way to get curcumin in your system. Curcumin is proven to reduce chronic inflammation, helping to prevent its negative long-term effects. Curcumin happens to be a powerful antioxidant, capable of neutralizing free radicals. Curcumin also stimulates the production of our body’s own natural antioxidant enzymes.Studies have shown that curcumin can help prevent cancerous cells from growing, multiplying, and spreading. It has even been found to kill some cancerous cells. For example, in a study of 44 men with lesions in the colon, which could possibly turn cancerous, curcumin was administered. The men were given 4 grams of curcumen per day for 30 days. At the end of the trial, the amount of lesions had decreased by 40%. A controlled study took 60 patients and divided them into three groups. One group was given Prozac, the other Prozac and curcumin, and the third just curcumin. The purely curcumin group experienced positive benefits, but the most effective treatment was found in the combination of Prozac and Curcumin.In a study, patients with rheumatoid arthritis experience better results from taking curcumin supplements as opposed to arthritis medication. This is likely due to curcumin’s anti-inflammatory properties The active chemical in turmeric, curcumin, is a wonder-molecule. Its many uses testify to its presence in human culture and Ayurvedic traditions dating back thousands of years. Its potentials are continuing to be studied, so that in the future we may learn even more about this magical molecule.

Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network
Public Library of Science (PLOS) , March 2017
The present study was aimed to unravel the inhibitory mechanisms of curcumin for lung cancer metastasis via constructing a miRNA-transcription factor (TF)-target gene network. We suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.

The power of turmeric
inews880.com, March 2017
The active ingredient that we’re also concerned about – or really interested in – is actually curcumin. It’s the main active ingredient which holds the most inflammatory and anti-oxidant potential. The beautiful thing about turmeric is that in all the recent studies and journalism and medical information that we have, it’s really effective against inflammatory conditions, like arthritis.

This centuries-old spice is the superfood of 2017
USA Today, March 2017
Turmeric fights inflammation, helps balance blood sugar and cholesterol levels. The University of Maryland Medical Center said it has been used for centuries to battle medical conditions and research suggests it may help treat cancer and colitis.

Turmeric trumps meds
Mirror, March 2017
Turmeric contains curcumin, a power antioxidant which has antiinflammatory properties. It is loaded with dietary fiber, niacin and the vitamins C, E and K, as well as potassium, calcium, copper, iron, magnesium and zinc. It acts as an immuno-booster, and helps in developing resistance towards many bacterial, viral and fungal infections. It also works like a muscle-relaxant by neutralising the extra gases and toxins produced in the body. Being rich in fibre and an antiinflammatory agent, curcumin also helps in weight reduction by reducing hunger pangs and raising the metabolic rate.

Curcumin decreases malignant characteristics
BioMedCentral.com February 2017
These findings indicate that curcumin may be a safe future chemotherapeutic agent.

 Environmental Nutrition
Orlando Sentinel, February 2017
"Curcumin is the compound in turmeric that gives it its bright yellow hue," says Rachael Hartley, R.D., L.D., C.D.E. It has been shown to block enzymes in the inflammatory pathways, potentially fighting inflammation at the molecular level, and it's being actively studied for relief of swelling and pain in both osteoarthritis and rheumatoid arthritis. Curcumin is also a powerful antioxidant, and lab and animal studies have reported that curcumin inhibits cancer at multiple stages of development, although we don't yet know how that might work in the body. The anti-inflammatory and anti-oxidant effects could help reduce heart disease risk, and this potent turmeric component also may help keep the lining of veins and arteries healthy and reduce cholesterol levels.

Curcumin Is Associated with Downregulation of Cell Division Cycle 20 in Pancreatic Cancer
Nutrients, February 2017
Curcumin could be useful for the treatment of pancreatic cancer patients.

Turmeric and Curcumin
Food.ndtv.com February 2017
 Curcumin belongs to a family of chemicals that are known as curcuminoid and which have a bright yellow colour. It is this compounds that lends the distinctive colour to the spice. Curcumin was first identified as a compound back in 1815. Since then, there have been several studies conducted to learn more about its abilities. It is believed that curcumin works on multiple functions and processes at the same time which is why it has been touted to cure everything from pain and inflammation to fighting tumours and promoting brain health.

Cancer prevention
inUth.com February 2017
Curcumin with chemotherapy can treat bowel cancer cells. The results were based on a laboratory test that showed that the combined treatment killed more cancer cells than the chemotherapy alone.

How Turmeric Upgrades Your Organ Systems & Treats Cancer, Inflammatory Disease
Collective-Evolution.com February 2017
Researchers have found that curcumin has a positive effect on multiple systems in the body. For one, curcumin has been found to modulate around 700 of our genes. Furthermore, it modulates over 160 physiological pathways. Curcumin also regulates our cell membranes, allowing for more efficient transport of molecules in and out of the cell. But one of the most amazing aspects of curcumin is its positive effect on signalling molecules, which, if gone awry, can lead to chronic inflammatory responses, autoimmune responses, issues with DNA and RNA regulation, and more. In short, curcumin is a vastly important ingredient in the prevention of almost all types of diseases.

Inhibitory Effect of Astragaloside and Curcumin on Tumor Growth
Anticancer Research, February 2017
The combination of AS-IV and curcumin demonstrated significant synergistic effects on microvessel count as well as on expression of angiogenic and thrombosis-related factors and microRNAs. Conclusion: The present study indicates future clinical potential of combination therapy with AS-IV and curcumin.

Over 7,000 studies confirm turmeric’s health-protective effects
Natural News, February 2017
A 2015 review published by the journal Molecules states that curcumin — a key component of turmeric — can inhibit the initiation, progression and metastasis of a number of different kinds of tumors. The review authors also note that curcumin halts disease progression by inducing apoptosis, or cell death. The team notes that at the time their review was completed, some 6,850 studies of turmeric had been published, noting that many of these were indicative of the spice’s potential health benefits. In their conclusion, the authors write, “A plethora of in vitro and in vivo research together with clinical trials conducted over the past few decades substantiate the potential of curcumin as an anti-cancer agent.”

Active compounds in turmeric, onion help fight colon cancer
Business Line, February 2017
Global research studies in the past decade have also thrown up positive results on the impact of curcumin in preventing colon and breast cancers. In a clinical trial, researchers in the US have shown that people who eat large amounts of curries with ingredients like turmeric and an antioxidant found in Onions called quercetin have beneficial effects. There is a growing body of scientific literature from across the world, including studies from the Hyderabad-based National Institute of Nutrition, which highlight properties such as anti-inflammation, antioxidant and anti-tumour attributed to curcumin.

Turmeric compound may treat colon cancer
Kashmir Monitor, January 2017
The researchers found that combination of two plant compounds that have medicinal properties - curcumin and silymarin - holds promise in treating colon cancer. Curcumin is the active ingredient in the spice turmeric. The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death.

Health Benefits of Curcumin
foods4betterhealth.com January 2017
Turmeric spice contains the healing compound, Curcumin, and studies have proved that it is more advantageous than many prescription drugs. Curcumin has a good ability to control inflammation. Oncogene published the results of a study stating that among all the anti-inflammatory medications in the world, aspirin and ibuprofen are the least effective, while curcumin is the most effective. Inflammation causes diseases like cancer, ulcerative colitis, arthritis, high cholesterol, and chronic pain. With arthritis drugs (diclofenac sodium), people may develop a leaky gut and heart disease, whereas with curcumin, treatment is safe and doesn’t have any adverse side-effects. The countless benefits of curcumin helps to treat people suffering from different types of arthritis.

Spice health benefits
The Gazette, January 2017
The active ingredient in turmeric is a powerful antioxidant called curcumin. The American Cancer Society notes that a number of studies have found curcumin kills cancer cells in vitro and reduces the size of tumors in animals.

Curcumin improves glucose tolerance
Mol Nutr Food Res., January 2017
These findings demonstrate the biological function of curcumin as a GLP-1 secretagogue and the possible molecular target that mediates GLP-1 secretion. Increases in the secretion of endogenous GLP-1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes.

Health Benefits of Turmeric
Factskeeper.com January 2017
One recent study actually found that curcumin from turmeric was more beneficial than some medications in reducing oxidative stress in the body, inflammation in the body, and treating high cholesterol.

Turmeric, the spice of life
CBS News, January 2017
The very thing that makes turmeric so colorful -- a compound called curcumin -- is what some researchers say also makes it a powerful weapon against disease. Biophysicist Ajay Goel has been studying its medicinal qualities at Baylor University Medical Center in Dallas. “We’re doing clinical trials on Alzheimer’s disease, Parkinson’s disease, arthritis, diabetes,” said Goel. “And it seems to have an effect on all these different conditions?” Cowan asked. “Absolutely. It is such a wonderful compound that has been shown to work in every single instance people have tried.” Goel says thousands of studies have shown that, in a concentrated-enough dose, the curcumin in turmeric has not only proven to be an effective antioxidant and anti-inflammatory, but also shows promise in preventing and even treating something as serious as cancer.

Study finds spices can help fight cancer
ABC News, January 2017
There's now a volume of scientific evidence showing that curcumin is a safe, and powerful anti-inflammatory. "What we were missing at that time, we didn't have the science behind it, we just knew that somebody took this and felt better," said Dr. Goel. After seeing an integrative medicine physician, she started on curcumin capsules daily to reduce inflammation. "So I tried it and it worked. There was nothing else I changed. No other variables whatsoever," Jones said. "It's a passion for me and I feel privileged in a sense that I can see the science and I can see the anecdotal evidence, and I can see the limitations. I can see the positive things," said Dr. Goel. Like possible cancer prevention someday on a plate. A previous study by Professor Goel found that taking curcumin while undergoing chemotherapy increased the effectiveness of the treatment. If you are shopping for supplements and want the full benefit of curcumin, buy curcumin capsules, not turmeric. Remember turmeric is the spice, curcumin is the medicine.

The medicinal properties of turmeric
Seattle Times, January 2017
The National Library of Medicine (PubMed.gov) contains thousands of research articles on turmeric or its active ingredient curcumin. That’s because there is intense interest in the medicinal properties of this Indian spice. Curcumin is being studied for its activity against psoriasis, diabetes, Alzheimer’s disease and a range of cancers. All of this research is being conducted in animal models, but the anti-inflammatory activity of curcumin has been shown to help nasal congestion in humans (Annals of Allergy, Asthma and Immunology online, Oct. 24, 2016). It also has been shown to help knee pain due to arthritis when taken as a supplement (Nutrition Journal, Jan. 5, 2016).

Curcumin sensitizes human gastric cancer cells
Chemical Biology Research Center, Wenzhou Medical University, December 2016
The combination of 5-FU and curcumin could be further developed as a potential therapy for human GC.

4 Ways Food Can Fight Muscle Soreness
IronMan.com December 2016
For centuries, curcumin has been prized in Asia for its purported benefits in health. Curcumin, like quercetin, has been investigated in a variety of exercise recovery models, including its impact on exercise-induced muscle soreness. A recent study compared the effects of 2.5 g curcumin or placebo taken twice daily for two days before and three days following a bout of heavy eccentric exercise. When subjects consumed curcumin, muscle soreness was lower at 24 and 48 hours after exercise with some evidence for enhanced recovery of muscle performance compared to placebo. In another study, subjects given 200 mg curcumin two times per day for 48 hours prior to and following a single bout of downhill running experienced less muscle soreness than subjects given placebo. Collectively, these findings suggest curcumin supplementation may dampen exercise-induced muscle soreness and support recovery.

Spice may help fight cancer
Vindi.com December 2016
The evidence is especially strong for curcumin, an active component of turmeric. It has the ability to interrupt metabolic pathways that cancer cells use to survive and spread (Anticancer Research, November 2016). Curcumin also may have activity against lung, breast, stomach, colorectal and uterine cancer.

The 7 Foods That Relieve Joint Pain
Tthe Weekly Challenger, December 2016
Curcumin, a compound found in turmeric, has been shown to help suppress cancer, reduce blood pressure, and have a positive impact on inflammation, just to name a few. One University of Arizona study found that the curcumin can help protect against joint deterioration and inflammation caused by rheumatoid arthritis. Another study researched how well ibuprofen eased pain over curcumin, and found that the benefits were about the same for both.

Study Finds the Spice Curcumin Fights Depression
MadeInAmerica.com December 2016
A new study, published online ahead of print in the Journal of Affective Disorders, finds that the spice curcumin, a derivative of turmeric, may be an effective treatment for depression. The study was a randomized, placebo-controlled trial (the gold standard methodology for medication studies). The researchers found that curcumin was better than a placebo treatment, and those with atypical depression were far more likely to improve.

 Compound in turmeric may treat colon cancer: study
The Hindu, December 2016
Researchers studied a line of colon cancer cells in a laboratory model. They found treating the cells initially with curcumin, then with silymarin was more effective in fighting cancer than treating the cells with either phytochemical alone. “The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death,” said Uthayashanker Ezekiel from Saint Louis University.

 The health benefits of tumeric
HanfordSentinel.com December 2016
Health benefits of curcurmin: Reduces whole body inflammation Reduces joint pain from arthritis Helps maintain healthy cholesterol levels Helps maintain body weight and may delay or reduce the onset of type 2 diabetes Reduces heartburn and stomach upsets Improves memory and brain function Good for skin problems Cancer prevention

Dietary inflammatory index and telomere length
American Society for Nutrition, December 2016
Lifestyle factors could affect the health and longevity of an individual by modifying telomere length (TL)12 (1), a molecular proxy for estimating cellular aging (2). In this context, several studies in humans have looked into the effects of dietary components on TL (1, 3–6). The 2 main mechanisms implicated in the association between diet and leukocyte TL are oxidative stress and inflammation (7). Therefore, it is expected that an antioxidant or an anti-inflammatory diet could lessen the rate of telomere shortening, which may delay aging. Indeed, a higher intake of specific antioxidants and anti-inflammatory dietary components such as vitamin C or E, polyphenols, curcumin, or omega-3 (n–3) fatty acids have been associated with longer telomeres.

Can You Spice Up Your Antidepressant? The evidence for curcumin in depression
Psychology Today, December 2016
Curcumin is more interesting than many other alternative-medicine highly-touted phytochemical compounds as an anti-inflammatory because there’s already about a decade of human data for adjunctive and/or remission stability improvement from curcumin in
autoimmune diseases such as ulcerative colitis. These studies show some benefit and very few side effects at fairly high doses, double or quadruple those used in the depression studies.

The 7 Incredible Health Benefits of Turmeric
ClapWay.com December 2016
With curcumin’s anti-inflammatory properties, turmeric helps stimulate the body’s natural defense mechanisms, which helps the body to heal and preserve itself naturally. The reputation of turmeric for reducing inflammation actually owes to its active ingredient, curcumin. You also may want to start adding ginger to your pain or inflammation tonics for an even more potent effect. Turmeric can assist in the lowering of cholesterol and also prevent the blockage of arteries that can cause heart attacks and strokes. Curcumin can lower cholesterol levels and also inhibit the oxidation of LDL.

6 Reasons to Always Have Turmeric
VozdeguanaCaste.com December 2016
Curcumin has substances that regenerate and protect the liver. A study by the Medical Association of Thailand links this substance to an effective fight against cancer and an improvement of the organ’s fibrous tissue, as well as to the regeneration of affected hepatic cells. Curcumin also is linked to improvements in gallbladder health.  Curcumin is important nourishment against cancer, as it blocks the development of cells and promotes apoptosis (cell self-destruction), differentiating between carcinogenic cells and normal ones. At the same time, it can halt metastasis (spreading of cancer from one organ to another), according to the findings of a 2011 study by the University of Texas Anderson Cancer Center.  According to the Arthritis Foundation, curcumin eases pain, swelling and stiffness associated with rheumatoid arthritis and osteoarthritis. Curcumin’s antioxidant and anti-inflammatory properties can be used as a complementary tool in the treatment of depression, according to a 2014 study published in the Journal of Affective Disorders.  According to the 2014 edition of the magazine BioMed Research International, several studies have shown that curcumin acts against a range of bacteria and microbes. Consuming it has antiviral, antimicrobial and antifungal effects.

Boost brain performance, reduce cognitive decline
BonnerCountyDailyBee.com December 2016
Curcumin, extracted from the spice turmeric, helps remove toxic waste, disrupt formation of plaques, and has anti-inflammatory properties. It tweaks a major control point that regulates many other activities in brain cells by encouraging them to operate in a balanced matter.

 The best supplements to take for over-60s
Startsat60.com December 2016
Due to its ability to block inflammation, curcumin could help stop disease-causing inflammation found in cancer, diabetes, cardiovascular disease, cystic fibrosis, and depression. Turmeric can also treat rheumatoid arthritis. Dr Greg Cole, associate director of UCLA’s Mary S Easton, spent years studying curcumin as a treatment for brain diseases specifically Alzheimer’s disease and dementia. In his long time studying curcumin as a cure, he has observed that it reduces the build-up of this disease in the brain.

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study
Journal of Affective Disorders, November 2016
Active drug treatments comprising differing doses of curcumin and combined curcumin/saffron were effective in reducing depressive and anxiolytic symptoms in people with major depressive disorder.

Study Says This SPICE Might Be As Effective For Depression As Prozac
inquisitr.com November 2016
This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders.

Healthy Living: Curcumin To Fight Cancer?
9and10news.com November 2016
A previous study found taking curcumin while undergoing chemotherapy increased the effectiveness of the treatment. If you are shopping for supplements and want the full benefit of curcumin, buy curcumin capsules, not turmeric. Remember turmeric is the spice, curcumin is the medicine.

The mood and cognitive effects of curcumin from turmeric
The Fiji Times, November 2016
Curcumin is the component of turmeric (Curcuma longa) that gives the spice — and many curries — its bright yellow colour. It is one of more than 5000 flavonoids, a group of plant-based compounds thought to contribute to the health benefits of fruit and vegetables. While any meaningful clinical effects are far from proven, at least the trials have a scientific foundation. Curcumin has significant anti-inflammatory properties that are said to rival those found in ibuprofen, the active ingredient in Nurofen. Unlike over-the-counter drugs though, turmeric has no known toxic effects on the body. Curcumin's powerful antioxidant advantages have been shown to protect healthy cells in research, particularly those found in the colon, from cancer-causing agents. It aids the body in destroying mutated cancer cells before they have a chance to spread to other areas.

5 Top Natural Cancer-Fighting Supplements
NewsMax Health, November 2016
Curcumin. Turmeric is a spice used to flavor traditional Indian dishes, and its active component is curcumin, a potent anti-inflammatory that gives turmeric its bright yellow color. Studies show it can fight even the deadliest cancer — pancreatic, which has a 5-year survival rate of only 7 percent. A Phase II clinical trial at MD Anderson Center gave 25 pancreatic cancer patients 8 grams of turmeric a day for two months. Tumor growth stopped in two patients, one for eight months and another for two-and-a-half years. Another patient's tumor temporarily regressed by 73 percent. The only two drugs approved by the FDA are effective in no more than 10 percent of patients, and turmeric's effectiveness was similar with no side effects. In another study, turmeric reduced tumor growth in mice with pancreatic cancer by 43 percent. When combined with fish oil, which helps the body absorb turmeric, tumor growth was reduced by 70 percent. A study at the University of Missouri found that curcumin decreased the incidence of progestin-accelerated breast tumors in animals. It also delayed onset of the disease and reduced the incidence of multiple tumors.

Let turmeric color your life
DELANO News, November 2016
Curcumin is also protective of the liver, it lowers blood fat levels and it reduces weight gain. In some cases it is effective against hay fever and it can help treat inflammatory skin conditions, too. Of course, as it is a bitter, it also stimulates digestion and keeps the digestive muscular system working smoothly.

The Healing Properties Of The Eastern Diet Explained
Luxury London, November 2016
Curcumin in turmeric works to fight free radicals and aid with blood flow and circulation.

Turmeric and Exercise: a Magic Combination for Heart Health
Care2.com November 2016
The magnitude of the improvement achieved by curcumin treatment was comparable to that obtained with exercise. Therefore, regular ingestion of curcumin could be a preventive measure against cardiovascular disease. Furthermore, results suggest that curcumin may be a potential alternative treatment for patients who are unable to exercise.

The 7 Foods That Relieve Joint Pain
The Huffington Post,November 2016
The health benefits of turmeric—the yellow spice that flavors curries—are vast. Curcumin, a compound found in turmeric, has been shown to help suppress cancer, reduce blood pressure, and have a positive impact on inflammation, just to name a few. One University of Arizona study found that the curcumin can help protect against joint deterioration and inflammation caused by rheumatoid arthritis. Another study researched how well ibuprofen eased pain over curcumin, and found that the benefits were about the same for both.

Curcumin modulates the effect of histone modification
International Journal of Chronic Obstructive Pulmonary Disease, November 2016
Curcumin may suppress chemokines and restore corticosteroid resistance in COPD through modulating HDAC2 expression and its effect on histone modification.

9 amazing health benefits of turmeric curcumin
BT.com October 2016
1. Kill cancer: The curcumin in turmeric has been found capable of killing cancer cells and able to slow the growth of tumours. 2. Soothe arthritis: “In a 2013 study, turmeric was shown to significantly reduce the severity of chronic joint inflammation in those with rheumatoid arthritis,” notes Abby Sauer, registered dietitian at Abbott. “In addition, turmeric has been considered as a promising treatment to reduce osteoarthritis pain due to its anti-inflammatory benefits.” 3. Fight diabetes: “When taken daily, turmeric’s most prominent component, curcumin, has been shown to delay the development of type 2 diabetes in patients who were at high risk of developing the disease,” says Sauer. 4. Deal with depression: Along with certified medical and psychological help, “turmeric has been shown to reduce depressive symptoms, and boost patient’s treatment success,” explains Sauer. 5. Avoid heart attacks: Those at risk of heart attack tent to suffer plaque build-up, known as atherosclerosis, in their arteries. “Turmeric has been found in animal studies to prevent blood clots from building up along artery walls, which could give patients with atherosclerosis a significant chance to reduce their risk of a heart attack,” says Sauer. 6. Tackle gut conditions: In patients with ulcerative colitis in remission, says Sauer, “turmeric was found to noticeably assist conventional medical treatment to keep patients in remission”. 7. Limit reflux: “Turmeric’s antioxidant and anti-inflammatory properties have been shown to reduce inflammation in the oesophagus,” which can cut the effects of reflux after eating, says Sauer. 8. Lower your cholesterol: That good old curcumin in turmeric has also been found to help balance out cholesterol levels. 9. Pain relief: Traditionally turmeric has been used as a natural painkiller, and have even been shown to mimic the effects of steroids.

Turmeric Beats Depression, Active Ingredient Curcumin Works As Well As Prozac
inquisitr.com October 2016
Multiple studies have now shown that the active ingredient in turmeric, curcumin, is an effective treatment against clinical depression and is as effective in treating serious depression as Prozac — perhaps even more so. Turmeric, a member of the ginger family, is probably best known for its culinary uses. It is frequently used in Indian dishes and as a natural food coloring because of its distinctive yellow color. Turmeric has been also used for thousands of years in treating a multitude of health conditions. Green Med Info, which compiles research studies on natural health products, lists over 2,000 research studies that proved benefits of turmeric ranging from treating arthritis to helping with weight loss to relieving symptoms of Irritable Bowel Syndrome, just to name a few. Hundreds of other health benefits of turmeric have also been reported.

If You Are Prone To Allergy, Make Sure You Regularly Eat These 10 Superfoods
Boldsky.com October 2016
The curcumin content in turmeric makes it a strong anti-allergic agent. Curcumin is an antioxidant and anti-inflammatory compound that equips our immune system to fight allergies.

Popular ingredient in Indian food may help fight cancer
WNDU.com October 2016
Taking curcumin while undergoing chemotherapy increased the effectiveness of the treatment. If you're shopping for supplements and want the full benefit of curcumin, buy curcumin capsules, not turmeric.

Spices with benefits
Food in Canada, October 2016
The active ingredient of turmeric, called curcumin, is a type of polyphenol. Among other things, curcumin has been shown to help prevent depression in mice, and scientists are studying its impact on treating Alzheimer’s disease. Studies on rats from a few years ago showed that turmeric could help prevent and maybe even reverse liver damage, and there are ongoing studies looking into its impact on treating or preventing cancer, particularly colon cancer. It’s also been studied as an anti-inflammatory, a treatment for arthritis, a preventative measure for people at risk of developing diabetes, and more.

Curcumin Can Protect Your Brain from Dementia and Alzheimer’s Disease
MensFitness.com October 2016
Curcumin—a bright orangeish chemical compound that’s found in turmeric and is integral to most curries and many other Asian foods (not to mention good old American mustard!) has already been shown to be a powerful anti-inflammatory. Now evidence is growing that it also stymies the destruction of brain neurons—meaning it may combat dementia and even Alzheimer’s disease. Researchers in a year long study at Australia’s Edith Cowan University gave cognition tests to 96 middle-aged and elderly subjects, then sent half of them home with concentrated curcumin pills, and the other half with a placebo. When all were retested just six months later, those who’d been taking the placebo showed a decline in verbal and memory skills—but the ones taking curcumin showed no such decline.

How Turmeric Wards Off Infectious Diseases
AllAfrica.com October 2016
Several medical properties have been attributed to Curcumin (Curcuma longa). The rhizome is known to possess therapeutic activities and has been used by medical practitioners as an anti-diabetic, hypo-lipidemic, anti-inflammatory, anti-diarrhoeal, hepato-protective, anti-asthmatic and anti-cancerous drug. Curcuma longa is widely used in cosmetology.

Curcumin fights ovarian cancer
ScienceDirect.com October 2016
Curcumin increases cytosolic Ca2+ concentration through inhibition of SERCA activity, causing apoptosis in ovarian cancer cells.

The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis
US National Library of Medicine, October 2016
Osteoarthritis is a significant medical condition for the aging population worldwide. Curcumin, a NF-κB suppressor, demonstrates potential as a treatment agent for osteoarthritis, a disease with an underlying inflammatory cause. Its efficacy in reducing pain, physical function, and quality of life among osteoarthritic patients has been demonstrated in many clinical trials. The effects of curcumin on osteoarthritis can be attributed to its ability to prevent apoptosis of chondrocytes due to inflammation predominantly, and oxidative stress to a lesser extent. Randomized controlled trials involving larger sample size and longer treatment, proper selection of patients, and improved formulation could better justify the use of curcumin as an alternative treatment for osteoarthritis.

Curcumin for Anti-Cancer and Other Profound Benefits
Natural Products Insider, October 2016
Curcumin is a naturally occurring chemical compound that is found in the spice turmeric. Several studies suggest curcumin might ease symptoms of osteoarthritis and rheumatoid arthritis, including pain and inflammation. Moreover, these potent anti-inflammatory benefits seem to be quite protective against some forms of cancer progression. However, curcumin has additional anti-cancer effects that are independent of its anti-inflammatory effects and thus is a heavily researched molecule for both cancer prevention and treatment. Studies have shown curcumin helps prevent several forms of cancer including breast, lung, stomach, liver and colon. It stops development of cancer by interfering with the cellular signaling aspects of this chronic disease. Interestingly, my research unveiled curcumin has "smart kill" properties that actually work to inhibit the growth of tumors and the spread of cancer in fundamental ways at the cellular level. It has the laboratory-proven capability to inhibit a particular cancer-promoting enzyme (COX-2), impede blood supply to cancer cells, induce tumor-suppressing genes, stop metastasis, kill lymphoma cells and prevent the regrowth of cancer stem cells. The ability to target cancer stem cells is one of curcumin’s most powerful anti-cancer properties. In fact, according to GreenMedInfo.com, a recent study describes the wide range of molecular mechanisms presently identified by which curcumin attacks cancer stem cells (CSCs), which are the minority subpopulation of self-renewing cells, within a tumor colony. These stem cells alone are capable of producing all the other cells within a tumor, making them the most lethal, tumoriogenic of all cells within most, if not all, cancers. Because CSCs are resistant to chemotherapy, radiation, and may even be provoked toward increased invasiveness through surgery, they are widely believed to be responsible for tumor recurrence and the failure of conventional cancer treatments. These are compelling findings, indeed. Furthermore, some of the most fascinating curcumin research also dovetails with what I experience so much of: muscle soreness. A new, double-blind, randomized-controlled study published in the European Journal of Applied Physiology in March 2015 indicated curcumin can help reduce pain associated with delayed onset muscle soreness (DOMS) and aid muscle recovery in physically active people.

This Is Why Turmeric Should Be In Your Kitchen Cupboard
Grazia Daily, October 2016
A new study published in the journal Phytotherapy Research has confirmed that the chemical curcumin found in turmeric is safe and effective in treating depression. Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumors.

Curcumin prevents muscle damage
Journal of Inflammation Research, September 2016
Exercise (Ex) increases reactive oxygen species and impairs antioxidant defense systems. Recent data suggest that curcumin (CW) possesses peroxisome proliferator-activated receptor gamma activity and anti-inflammatory properties. Therefore, this study was designed to investigate the effects of CW supplementation on Ex performance, endurance, and changes in serum and muscle proteins in rats after exhaustive Ex.

Curcumin and silymarin form promising pair for colon cancer treatment
Yahoo.com, September 2016
The Journal of Cancer has published a study revealing the therapeutic effects of two antioxidant compounds when combined to fight colon cancer. Curcumin is the active ingredient in turmeric, already known for its anti-inflammatory properties, whereas silymarin, a component of milk thistle, has been used to treat liver disease. In laboratory tests, researchers from Saint-Louis University in the USA found that colon cancer cells stopped multiplying and spreading, and that cell death increased when exposed to the two natural compounds.

Curcumin helps lung cancer
Foodconsumer.org September 2016
The scientists found curcumin supplementation down-regulates the expression of inflammation biomarkers and promotes apoptosis in cancer cells.

Colon Cancer Treatment: Turmeric Compound ‘Curcumin’ Highly Effective, New Study Finds
Science World Report, August 2016
A new study has found that curcumin, a compound present in spice turmeric, has the potential to treat and prevent colon cancer.

To add some spice
The Daily Star, August 2016
Curcumin, the active component of turmeric, is an object of research owing to its properties that have the potential to turn off certain genes that cause scarring and enlargement of the heart. Regular intake may help reduce low-density lipoprotein (LDL) or bad cholesterol and high blood pressure, increase blood circulation and prevent blood clotting, helping to prevent heart attack. Curcumin also kills cancer cells and reduces the size of tumours. Turmeric aids in treating arthritis, heartburn, stomach pain, diarrhoea, intestinal gas, stomach bloating, and loss of appetite. Turmeric is also used as a topical treatment for issues like skin inflammation, infected wounds, and ringworm.

Naturally Detox
PopSugar, August 2016
This super spice contains high levels of a compound called curcumin, which has powerful antioxidant and anti-inflammatory actions. According to a study in the Journal of the Medical Association of Thailand, curcumin enhances liver health and offers protection from liver cancer and disease. This powerful antioxidant can also repair and regenerate damaged liver cells. It's basically magic in a spice.

5 reasons why you must include ‘haldi’ in your diet
Tribune, August 2016
Curcumin supplements showed that root can potentially prevent heart attacks. This particular study was conducted on a group of patients that had previously undergone bypass procedures. It was proved that 30% of the individuals from the placebo group experienced heart attacks during their hospital stay, compared to only 12% of the ones from the supplement group. Keep in mind that this does not mean you start swallowing large spoonfuls of the spice to avail all these health benefits. The powdered spice in your kitchen contains less than 10% of Curcumin. Consult your physician to learn about FDA recommended supplements for best results.

Suffering from colon cancer? Turmeric may be the cure
Science Daily, August 2016
A preliminary cell study finds combining curcumin, the active ingredient in spicy curry dishes, and silymarin, a component of milk thistle, inhibited the spread of colon cancer cells and increased cancer cell death.

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Turmeric-Curcumin.com is our company and website, dedicated since 2000 to offering the highest quality Curcumin 95% extract, the best customer service, the lowest prices in the industry, and none of the marketing hype. We are not like retailers selling 500 products, or even 5 products. We are the manufacturer, dedicated and focused on the most powerful, healthful and important compound in botanical medicine; Curcumin, concentrated and standardized to 95% purified extract. This extraordinary spice extract has generated such interest that universities and medical centers around the world are continually conducting research studies and discovering new benefits, with multiple ongoing human clinical trials. Due to it's potent antioxidant power, Curcumin has been recognized as one of the most promising food-derived compounds in fighting a variety of degenerative diseases. The scientific evidence remains overwhelming, demonstrating the many health benefits via in vitro, in vivo and human clinical studies. You will receive a 100% additive free product: no starch, no sugars or sweeteners, no artificial colors or flavors, no sodium, no soy, no yeast, no wheat, no corn, no rice or other grains, no gluten, no dairy, no preservatives, no GMO, no dyes, no gums, and no black pepper extract, piperine, or "bioperine" which is actually a trademark of the Sabinsa corporation. For any questions or comments, feel free to email support@turmeric-curcumin.com (or call and leave a message with your email) and we will respond as quickly as possible.

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