The most powerful compound in botanical medicine,
the worlds most important herbal extract.

 

  What is Turmeric and Curcumin?
Turmeric is a member of the Curcuma botanical group, which is part of the ginger family of herbs, the Zingiberaceae. The root and rhizome stem of the Curcuma longa plant is crushed and powdered into ground Turmeric. Ground Turmeric is used worldwide as a seasoning and is the source of Curcumin.
curcumin turmeric

curcumin turmeric
Curcumin is a natural component of the rhizome of Turmeric (Curcuma longa) and one of the most studied phytochemicals. It is extracted, concentrated, standardized and researched in supplement form.

 

  What are the researched properties of Curcumin? 

"Curcumin is the most widely-studied plant-derived medicinal chemical in modern science. Based on a statistical analysis of over three million published scientific studies, Curcumin is the most frequently mentioned phytonutrient." - NaturalNews.com, July 2013
 

"The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive." - Science News Magazine
 

"Worldwide, there are over 1000 published animal and human studies, both in vivo and in vitro in which the effects of curcumin on various diseases have been examined. Studies include epidemiological, basic and clinical research on AD." - Acad Neurol. 2008 Jan-Mar; 11(1): 13–19. The effect of curcumin (turmeric) on Alzheimer's disease: An overview
 

"Because of the crucial role of inflammation in most chronic diseases, the potential of Curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of Curcumin have been examined in animals and in humans." - Trends Pharmacol Sci. 2009 Feb;30(2):85-94. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
 

"Six hundred and eighty-eight studies, more than 400 of them published within the last four years, confirm Curcumin's remarkable anticarcinogenic, anti-inflammatory, and antioxidant properties. Within the last year, interest in Curcumin's potential as a neuroprotective agent have been rising." - Worlds Healthiest Foods

 
  Where can I purchase Curcumin?
Order direct from Turmeric-Curcumin.com, the largest supplier of Curcumin supplements at wholesale prices to the general public, research institutions, physicians, and university medical centers for over thirteen years. Quality control tests, laboratory analysis certification, and rigorous cGMP manufacturing standards all ensure freshness, potency,and purity of content material. Orders are shipped FedEx or USPS Priority for fast and secure delivery. Contact support@turmeric-curcumin.com for bulk ordering, private labeling or any other questions. Multiple bottle orders will receive quantity discounts listed below, 12-bottle case purchases will also receive free US shipping.


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  Curcumin 95% standardized herb extract.
Health-conscious consumers should be careful in selecting a Curcumin extract product, making sure that they know what they’re getting. Some buyers may have heard about Curcumin but may not be familiar with the difference between it and Turmeric, and may confuse the two. Our extract is standardized to contain a minimum of 95% Curcuminoids: Curcumin (C), Demethoxycurcumin (DMC), Bisdemethoxycurcumin (BDMC) - the complete range in their natural composition ratio of 76:19:5. Thus, in our product the full spectrum of Curcumin antioxidant Curcuminoids are extracted from Turmeric (Curcuma longa root) and represented in their natural arrangement for maximum potency. This is the same material used in clinical trials and medical studies, free of added chemicals, 'enhancements', or treatments. Unlike many antioxidants, Curcumin is capable of both preventing free radical formation, as well as neutralizing existing free radicals, and is considered an effective bioprotectant due to this dual activity. We supply the purest Curcumin available, standardized to minimum 95% extract
 

  500 milligrams per capsule.

Consumers may be misled by deceptive labels, believing there is much more true Curcumin in a product than there really is. Some examples of these misleading claims which make it difficult to tell how much active Curcumin extract is actually included are "1000 mg per serving" but the serving size is 4 capsules; 500 mg "enhanced formula" but contains only 200 mg Curcumin extract, and the remainder is 300 mg Turmeric spice; 1000 mg "super complex" which contains only 250 grams of Curcumin extract and the remaining 750 grams is just Turmeric spice. The amount of "Curcumin complex" is listed on the label rather than the amount of active Curcumin extract. Thus, a product labeled "1000 mg Curcumin (25%)" does not even deliver 300 mg of Curcumin, since Turmeric powder averages only 3.14% Curcumin by weight. - 55(2):126-31. These deceptions are not uncommon in the supplement industry, even by the largest vitamin shops. The solution is to compare; look for a label that clearly indicates the contents (Curcumin extracted from Turmeric root), the concentration (95%) and the amount (500mg) for each capsule, not per serving. Our product contains 500 milligrams per capsule of 95% standardized Curcumin extract. There is no claimed "enhancing" material to fill the capsule up and lower the Curcumin percentage. Our product contains no sugars or other sweeteners, no artificial colors or flavors, no starch, no sodium, no soy, no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa corporation), no GMO, no dyes, no gums or any other unnecessary compounds.
 

  200 capsules per bottle.

For the environment as well as your finances, we don't require purchasing two or three bottles to obtain 200 capsules. Each bottle contains the full 200 capsules, with every 12-bottle case totaling over two and a half pounds of pure Curcumin extract. The suggested serving size is one (1) to four (4) capsules with each meal, preferably with beneficial oils and fats, potentially offsetting the inflammatory response process that occurs during ingestion and digestion.
 

  Are there any side effects or interactions related to Curcumin or Turmeric?

"Curcumin is not toxic to humans up to 8,000 mg/day."- Phase I Clinical Trial of Curcumin, 21(4B):2895-900. 

"Patients received 8 g curcumin by mouth daily...No toxicities were observed." -  Phase II ClinicalTrial of Curcumin, Clin Cancer Res. 14(14):4491-9.

"Curcumin, even in large quantities, does not produce any known side effects in humans." - Blood.101(3):1053-62. Turmeric has been used in large quantities as a condiment for thousands of years with no adverse reactions.  The US FDA classifies Turmeric as GRAS (Generally Recognized As Safe). Pregnant women, individuals with gallstones or using blood thinners should consult a health care provider before using herbs or dietary supplements in amounts greater than usually found in foods.

 

  Has the absorption and bioavailability of Curcumin 95% powder been studied?

"The average peak serum concentrations after taking 4,000 mg, 6,000 mg and 8,000 mg of curcumin were 0.51 microM, 0.63 microM and 1.77 microM, respectively." - Phase I Clinical Trial of Curcumin, 21(4B):2895-900

"Traces of curcumin were detected in the plasma. Its concentration in the small intestinal mucosa, between 39 and 240 nmol/g of tissue, reflects differences in dietary concentration...The comparison of dose, resulting curcumin levels in the intestinal tract, and chemopreventive potency suggests tentatively that a daily dose of 1.6 g of curcumin is required for efficacy in humans." - Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):535-40

"One hour after administration, the levels of curcumin in the intestines, spleen, liver, and kidneys were 177.04, 26.06, 26.90, and 7.51 microg/g, respectively." - Drug Metab Dispos. 1999 Apr;27(4):486-94

 
  What are the chemical properties of Curcumin?
Chemical Name Diferuloylmethane
Definition A β-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups
Systemic Name (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)
Molecular Formula C21H20O
Molar mass 368.38 g/mol
Appearance Bright yellow-orange powder
Melting Point 183 °C, 361 °F
PubChem 969516
Biofunction Enzyme cofactor
Chemical Taxonomy Organic Chemicals / Hydrocarbons / Aromatic Compounds /  Phenols / Catechols / Curcuminoids
Chemical Structure 3D
Chemical Structure

   

Organic Source Taxonomy Kingdom
Subkingdom
Superdivision
Division
Class
Subclass
Order
Family
Genus
Species
Plantae (Plants) 
Tracheobionta (Vascular plants)
Spermatophyta  (Seed plants) 
Magnoliophyta  (Flowering plants)
Liliopsida  (Monocotyledons) 
Zingiberidae
Zingiberales
Zingiberaceae  (Ginger family) 
Curcuma (Curcuma)
Curcuma longa  (Turmeric)
 

  Why Turmeric root extract Curcumin may provide health benefits?

Certain plants manufacture chemicals that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of organic compounds that deter attackers become more successful, because of their advanced protection. In nature's never-ending interaction between predator and prey, insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring this evolution between plants and insects represents an important field of ecological research. Scientists have discovered that many phytochemicals manufactured in plants and roots not only prevent insect attack or fight plant infections, but also provide human health benefits. Many cultures create their own botanical pharmacies as the lore of medicinal plants and remedies is handed down through generations of healers. With the advent of sophisticated laboratory testing, biologists are finding that the many indigenous plants and roots from around the world provide medicinal value, and their metabolites are candidates for research. Curcumin’s structure is similar to other natural polyphenolics (chemicals containing multiple "phenol" groups) produced by plants in response to infectious attack. These natural polyphenols often have potent anti-oxidant and anti-inflammatory properties as well as immune support health benefits. Curcumin from Turmeric, resveratrol from grapes, pterostilbene from blueberries, and catechins from green tea all contain polyphenolic antioxidants and have been studied for medicinal or preventive value. Curcumin has been studied for anti-oxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities, mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered TNF blockers (humira, remicade and enbrel), vascular endothelial cell growth factor blocker (avastin), human epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib), and HER2 blocker (herceptin). Considering the recent scientific bandwagon that multi-targeted therapy is better than mono-targeted therapy for most diseases, Curcumin is a phytonutrient that can be considered an ideal "Spice for Life". More than 5000 papers published within the past two decades have revealed that Curcumin has extraordinary potential in promoting health through modulation of numerous molecular targets.

 

  What is the history of Curcumin and Turmeric?

Turmeric is an ancient spice and a traditional remedy. Its health benefits have been described for thousands of years in traditional Indian (Ayruvedic) and Chinese medicine largely because of its proven efficacy in treating conditions with inflammation. These ancient civilizations have vast trial and error experience with many different herbal remedies and food preparations and they selected curcumin as a food additive and major tool for medicinal use based on efficacy. Since 1900 BC numerous therapeutic activities have been assigned to Turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastro-intestinal systems, aches, pains, wounds  and disorders. Marco Polo, writing of his travels in China, described Turmeric in the 13th century: "There is also a vegetable which has all the properties of the true saffron, as well as the color, and yet it is not really saffron. Turmeric is held in great estimation, and being an ingredient in all their dishes, it bears, on that account, a high price."  The high degree of reverence for Turmeric is established by the fact that it is used in many cultures, each having its own name for the spice: Burmese:fa nwin.  Chinese:wong geung fun, yü chiu.  Danish:gurkemeje.  Dutch:geelwortel.  Finnish:keltajuuri.   French: curcuma, saffron des Indes.  German:gelbwurz, kurkuma.   Icelandic:turmerik.  Italian: curcuma tumeric  Indian:haldee, haridra, haldi, huldee, huldie. Indonesian:kunjit, kunyit.   Japanese:ukon circumin   Malay:kunjit.  Norwegian:gurkemeie,  Polish:klacze kurkumyPortuguese:açafrão-da-Índia.   Russian:zholty imbir.  Spanish:azafrán de la India, azafran arabe.   Sinhalese:kaha. Swedish:gurkmeja.  Tamil:munjal.   Thai:ka min.  Vietnamese:bot nghe
 
  Why hasn't the pharmaceutical industry patented Curcumin?
Multinational pharmaceutical corporations tried registering patents for Curcumin and Turmeric because of the much heralded scientific evidence and the long history of its healing properties. However, that same evidence and history of Turmeric and Curcumin being used medicinally for centuries was the reason the United States Patent and Trademark Office rejected and revoked the rights for Turmeric patent 5401504 on the grounds that the claims were not new: "USPTO unequivocally rejected all six claims made on August 13, 2001 ruling that Turmeric's medicinal properties were not patentable."  University of Texas MD Anderson Cancer Center states "in the case of Curcumin, a natural compound, no company can reap the benefits if Turmeric shows itself to be an effective anti-cancer drug." This loss to Big Pharma is a gain for educated consumers.
 

  What are the studied pharmacological actions of Curcumin?

Cancer (46), Ovarian cancer (42), pituitary (41), Tumor (40), Cirrhosis (39), radiation (38), blood (38), Inflammatory (37), colon cancer (37), prostate (37), Cytotoxicity (36), Melanoma (36), Hypothyroid (36), prostate cancer (36), Colitis (36), Anti-Inflammatory (35), Chemopreventive (34), breast cancer (34), Seizures (34), HPV (34), Antiviral (34), Granuloma (34), Pulmonary fibrosis (33), Leukemia (33), Osteosarcoma (33), Apoptotic (33), diabetes (34), Allergy (33), endometriosis (33), skin (33), Antioxidants (33), Squamous cell carcinoma (33), Liver damage (32), Colorectal cancer (32), chemotherapy (32), lymphoma (32), neurons (32), Neuroprotective (32), Anti-Apoptotic (32), Antimicrobial (32), Oxidant (32), Neurogenesis (32), Gastric cancer (32), Schistosomiasis (31), Neuroblastoma (31), Sepsis (31), Death (31), Emphysema (31), alzheimer's (31), Proteasome Inhibitors (31), Hepatoma (31), cartilage (31), Cytotoxic (31), Antifungal (33), spinal cord (31), Pancreatitis (30), Anti-Tumor (30), Antiproliferative (30), Tumorigenic (30), arthritis (30), dementia (30), Periodontal disease (30), Cardiovascular (30), Contraceptive (30), Insulin Resistance (30), Radiosensitizer (30), Multiple myeloma (30), Cyclooxygenase Inhibitors (30). Helicobacter pylori infection (30), Myeloma (30), Cervical tumor (30), Diabetic nephropathy (29), Herpes simplex (29), Dopaminergic (29), Telomerase Inhibition (29), Cell cycle arrest (29), Serotonergic (29), pain (29), Immunomodulatory (29), Genotoxic (29), flu (29), Bladder tumor (29), Proliferative (29), Carcinogenic (29), Caspase-3 Activation (29), hepatic injury (29), Chemotherapeutic (29), Meningitis (29), Anxiety (28), Atherosclerosis (28). Uveitis (28). Parkinson's disease (28), Gastroprotective (28), Testes (28), Inflammatory Bowel Disease (28), hypothalamus (28), Chronic Renal Failure (28), cervical cancer (28), Human papillomavirus (28), COPD (28), Carcinogen (28), NF-kappaB Inhibitor (28), Hepatocellular carcinoma (27), Cataractogenic (27), cystic fibrosis (27), Sarcoma (27), Immune system (27), Chemosensitizer (27), Anti-Angiogenic (27)Small intestine (27), Antineoplastic (27), Osteoarthritis (27), Chondroprotective (26), Mesenteric Ischemia (26), Oxidants (26), Imbalance (26), Phototoxicity (26), Fever (26), chronic fatigue (26), Encephalitis (26), hepatitis (26), Hepatitis C (26), Hypoglycemic (26), Hematologic (26), Diabetic retinopathy (26), Hodgkin's lymphoma (25), Ulcerative colitis (25), anemia (25), Vitiligo (25), Uncoupling (25), Bile duct cancer (25), Parkinsonism (25), Hematopoietic (24), Atrioventricular (24), Cholinergic (24), Subarachnoid Hemorrhage (24), HIV (24), Anti-Proliferative (24), Prostatitis (24), Glycine (31), Anti-Bacterial (23), Anti-Ulcer (23), liver disease (23), Hyperthyroidism (23), Tongue (23), Hepatoprotective (23), Ewing's sarcoma (23), Stroke (23), Malaria (23), Hepatitis B (22), depression (21), Amnesia (21), Dopamine (20), pharynx (19), Leptin resistance (17)

   
  How may Curcumin work against cancer?
Studies on Curcumin and Cancer. Independent research studies on suggest that Curcumin has the potential for treatment of cancers including colon, breast, prostate, lung, skin and bowel. Curcumin is one of the most powerful and promising chemopreventive and anticancer agents, and epidemiological evidence demonstrates that people who incorporate high doses of this spice in their diets have a lower incidence of cancer. Curcumin's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic investigators around the world. Because of low toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology testing and has successively made it through the first stages (Phase I) of clinical testing abroad and is currently in clinical trials at several sites in the U.S. Numerous mechanisms have been described for the anticancer activity of Curcumin. >Researchers at M.D. Anderson Cancer Center in Houston, TX state that Curcumin has “enormous” potential to prevent and treat cancer. Curcumin was able to suppress tumor formation, growth, and even metastasis according to their review. Currently, there are clinical trials being conducted on the effects of Curcumin on patients with bowel cancer. Inhibition of proliferation of tumor cells, induction of apoptosis (a mode of cell death), inhibition of transformation of cells from normal to tumor, inhibition of invasion and metastasis and suppression of inflammation have been linked with the activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules, inflammatory cytokines, chemokines, growth factor receptors, vascular endothelial growth factor (VEGF) and transcription factors by Curcumin have been linked to its antitumor activity. Curcumin also has been studied with regards to the core inflammatory gene signal, NF-kappaB,resulting in a beneficial domino effect throughout the body. One benefit of this domino effect is a direct reduction in the risk of cancer from overweight-induced inflammation.
 
  How may Curcumin work against arthritis?
Arthritis is also a proinflammatory disease. All current drugs approved for arthritis have anti-inflammatory activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production, block the action of TNF, and have activity against arthritis. When inflammation is reduced, the added benefit is pain relief. A double-blind, crossover study showed that Curcumin may be  effective in relieving pain and improvements in morning stiffness, walking time, and joint swelling.
 
  How may Curcumin work against Crohn's disease and Ulcerative Colitis?
Crohn’s disease is also a pro-inflammatory disease. All current drugs approved for this disease have anti-inflammatory activity. Anti-TNF therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production and the TNF action. Curcumin taken orally has been shown to have activity against inflammatory bowel disease. Study results suggest that Curcumin could have a protective role in ulcerative colitis via regulation of oxidant/anti-oxidant balance and modulation of the release of some inflammatory endocoids, namely TNF-alpha and NO. The development of DSS-induced colitis was significantly attenuated by curcumin. Inhibition of p38 MAPK signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and the nitrite production in colonic mucosa, reducing the development of chronic experimental colitis. In addition, Curcumin seems promising with regards to remission in patients with quiescent Ulcerative Colitis.
 
  How may Curcumin work against against diabetes?
Curcumin acts directly on liver cells to help prevent them from becoming fatty, and studies have concluded that Curcumin may have an anti-diabetic effect by decreasing serum fatty acid through the promotion of fatty acid oxidation and utilization. Curcumin also works directly on pancreatic beta cells to help them produce insulin normally. By helping the liver and the pancreas, Curcumin is taking stress off the two most important organs whose function declines before the onset of type 2 diabetes. Curcumin also influences key hormones, supports major body organs, and regulates inflammatory signaling all in ways that help correct or prevent metabolic problems. Curcumin helps lower inappropriately high levels of leptin (reducing leptin resistance) while boosting the all-important levels of the adiponectin (which lowers insulin resistance). Curcumin also helps activate the fat-burning gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat cells. Curcumin directly reduces major inflammatory events from occurring inside white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte chemotactic protein-1). By lowering such inflammation, the source of overweight-induced disease is targeted.
 
  How may Curcumin work against obesity AND metabolic syndrome?
In the prevention and treatment of obesity and metabolic syndrome, Curcumin has been reported to modulate numerous targets that have been linked to obesity and insulin resistance. 1) Curcumin has been shown to downregulate the expression of TNF in various tissues. 2) Curcumin can suppress NF-κB activation induced by a wide variety of inflammatory agents through inhibition of degradation of IκBα. 3) Curcumin can inhibit the activation of IKK linked to the activation of NF-κB, and this leads to the suppression of expression of inflammatory biomarkers such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor. 4) Curcumin has been shown to downregulate the expression of various NF-κB-regulated proinflammatory adipocytokines including chemokines (such as MCP-1, MCP-4, and eotaxin) (199) and interleukins (IL-1, IL-6, and IL-8). Curcumin also suppressed the expression of plasminogen activator inhibitor type-1 through the inhibition of the transcription factor early growth response (Egr)-1 gene product that has been closely linked with insulin resistance and obesity. 5) Curcumin has been reported to mimic most antidiabetic drugs in that it activates PPAR-γ in hepatic stellate cells. 6) Curcumin has been shown to downregulate activation of c-Jun NH2 terminal kinase. 7) Curcumin has been shown to inhibit the Wnt/β-catenin pathway, which is closely linked to obesity. Later studies have indicated that Curcumin inhibits Wnt pathway signaling through downregulation of the transcription coactivator p300. Another potential mechanism by which Curcumin could inhibit β-catenin signaling is through inhibition of glycogen synthase kinase (GSK)-3β, which directly causes the phosphorylation of β-catenin. Curcumin was found to inhibit GSK-3β with as little as 66 nM IC50 (32). 8) Curcumin has been shown to induce the expression of hemeoxygenase (HO)-1 through the activation of Nrf2 in pancreatic cells and thus mediate the survival of these cells. 9) Curcumin downregulates the secretion of insulin-like growth factor-1 but induces the expression of insulin-like growth factor binding protein-3. 10) Curcumin interrupts leptin signaling by reducing phosphorylation levels of the leptin receptor (Ob-R) and its downstream targets. 11) Curcumin suppresses gene expression of Ob-R in HSCs. 12) Curcumin has been reported to increase the expression of adiponectin, which negatively controls obesity.
 
  How may Curcumin work against psoriasis?
Psoriasis is another pro-inflammatory disease. Considerable evidence, both in animals and humans, indicates that Curcumin may be effective against psoriasis.
 
  How may Curcumin work against Alzheimer's disease?
Researchers found that Curcumin not only reduces oxidative damage and inflammation, but also reduces amyloid accumulation and synaptic marker loss and promotes amyloid phagocytosis and clearance. Curcumin worked to prevent synaptic marker and cognitive deficits caused by amyloid peptide infusion and abeta oligomer toxicity in vitro, and may help the immune system clear the brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Clinical trials are in progress at UCLA with Curcumin for Alzheimer's. In the Alzheimer’s Disease Anti-Inflammatory Prevention Trial, researched showed that reducing inflammation has positive effects on patients with Alzheimer’s. Curcumin significantly lowered several inflammation markers, in addition to reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent.
 
  How may Curcumin work as an Anti-inflammatory?
Turmeric is safe and non-toxic and has been studied for anti-inflammatory properties, inhibiting various molecules that contribute to inflammation such as lipooxygenase, COX-2, leukotrienes, prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis factor (TNF), and interleukin-12 (IL-12).  One study compared the effectiveness of Curcumin – the active ingredient in turmeric – and a popular non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone. At the end of the six days, those taking the Curcumin and the NSAID enjoyed a significantly better anti-inflammatory response than placebo. The spice worked as well as the drug, but without the negative side effects.
 
  Recent news and published studies on Curcumin and Turmeric

March  2014

Herbal supplements have anti-cancer activity

Ocala.com March 2014
Curcumin, one of the active compounds in turmeric spice, popular in Indian cuisine. Many studies prove curcumin slows down the growth of different types of cancer. Curcumin may be helpful for pancreatitis because it reduces inflammation in the pancreas and reduces inflammatory pain-causing chemicals. Wonderful, but you may need special IVs or supplements to get it to work.

Using certain spices may improve health

CapeGazette.com March 2014
In animal studies, turmeric’s bright yellow pigment, curcumin, has been effective in preventing tumor formation. Observational studies in populations that consume large amounts of curry have strongly suggested that curcumin may help prevent cancer in the lower intestine.

Turmeric can fight colon cancer

Paktribune.com March 2014
Curcumin, an active ingredient of turmeric, can fight colon cancer when used in combination with a popular anti-inflammatory drug, say researchers...Curcumin increases the anti-cancer and anti-inflammatory effects of Celecoxib while reducing its dose, thus reducing its toxic side-effects, including the rate of heart attack and stroke.

WonderWoman.in March 2014
"We studied the effects of curcumin on patients with major depressive disorder," says study author Ajay Goel, PhD, director of epigenetics and cancer prevention at Baylor University Medical Center. "It's possible it may help alleviate short-term mood issues, too." Curcumin inhibits the production of monoamine oxidase, an enzyme that at high levels is linked to depression.

New Study Confirms Turmeric Can Benefit Diabetes

GuardianLV.com March 2014
Over a series of six months the study revealed the involvement of turmeric extract, curcumin does stop the fatty deposits forming on the inner surfaces of the arteries obstructing the blood flow...The trials results in curcumin being used without any serious unwanted effects and revealed lasting benefits for diabetes patients. Turmeric is well-known for its liver healing properties Curcumin is the active ingredient that gives turmeric its orange-yellow color. Along with related chemicals, it comprises the extraction of curcuminoid.

Spice Up Your Health With Seasonings That Fight Diseases

CharismaNews.com March 2014
“Turmeric contains curcumin, which can inhibit the growth of cancer cells,” she says. “It reduces inflammation. It supports your immune system, it’s great for your liver function, and, as you know, it’s used in Indian cooking.”

Memory-enhancing tips and supplements

Ocala.com March 2014
Put curcumin, the active ingredient of the common spice, turmeric, at the top of your list of Alzheimer's preventives. Seriously. Researchers have published 1,000 scientific studies on the antioxidant and anti-inflammatory properties of curcumin. A recent Japanese study showed symptom improvement for those who supplemented with turmeric capsules for one year. Two participants who had severe cases were even able to recognize family members by the study's conclusion. Back in 2008, researchers in India published a paper reviewing the major research done on curcumin as a treatment for Alzheimer's. They noted that curcumin apparently has the ability to help a component of the immune system (macrophages) clear away amyloid plaques from the brain. They concluded, “…based on the main findings above, curcumin will lead to a promising treatment for Alzheimer's.”

Now, tumeric powder drug to help beat breast cancer

NewsTrackIndia.com March 2014
Curcumin, a spice used in the preparation of tumeric powder, reduced the size of tumours in mice by a third while slowing the reproduction rate of rogue cells, the Daily Express reported.

Natural Products for Good Health

News.am February 2014
A study at Baylor University found that curcumin, the main compound in the spice turmeric, worked as well as the popular antidepressant Prozac. Study participants were divided into three groups: one took 500 milligrams of curcumin twice a day; the second took a standard dose of Prozac, and the third group took a combination of both. After six weeks, curcumin relieved symptoms of depression as effectively as Prozac. 

Natural Superfoods May Help Fight Prostate Cancer

Atlantablackstar.com February 2014
Curcumin is a natural carotenoid and polyphenol which may be isolated from Curcuma longa or turmeric, a rhizome. Owing to their structure, carotenoids are scavengers of free radicals, which make them great anti-oxidants and boosters of the immune system of vertebrates, humans included. Curcumin is also an effective antibacterial agent and anti-carcinogenic. Studies have demonstrated that curcumin inhibits the growth of a number of tumors when used in combination with radiation therapy. In prostate cancer, curcumin overcomes the effect of prosurvival gene expression induced by the exposure of cancer cells to radiation.

WorldBulletin.com February 2014
The curcumin diet significantly reduced bile duct blockage and curbed liver cell damage and scarring by interfering with chemical signalling pathways involved in inflammation.

Curcumin: A Double Hit Against Mesothelioma

February 2014
Curcumin, the primary component in the dietary spice turmeric, may be a powerful ally in the fight against malignant mesothelioma. The new study, published in the journal Cancer Prevention Research, finds that curcumin may both attack existing mesothelioma cells and protect against the development of new ones. Curcumin is a polyphenol with anti-inflammatory properties. Numerous studies have confirmed its ability to help fight cancer, including mesothelioma. In the newest study, a team at the University of Vermont tested curcumin on human mesothelioma cell lines as well as cells derived from infected mice.

Fighting cancer with plant molecules: Indian scientists show the way

TwoCircles.net January 2014
Curcumin has been shown to be particularly beneficial in this aspect. "These phytochemicals showed their efficiency to counter DNA damage caused by arsenic. This DNA damage initiates the process of cancer development; therefore reduction of such damage may pave a way to cancer prevention. Apart from this, phytochemicals also play a role in repair of DNA damage. We conducted a field study where curcumin has been found to be of great value in combating the problem with arsenic at the genetic level."

Six Ways Curcumin Can Help You Sleep More and Stress Less

Huffington Post December 2013
Take advantage of curcumin (the substance that gives turmeric it's bright yellow colour) because it can dramatically improve your health. The anti-inflammatory and antioxidant powers of curcumin prevent and fight a wide variety of conditions ranging from sleep deprivation to stress, and beyond.

Spices, a valuable addition to a heart-healthy diet

The Financial Express January 2014
The benefits for heart health arise from curcumin, an active principle which is anti-oxidant, anti-clotting, anti-inflammatory and anti-proliferative. Several scientific studies have documented the effect of curcumin in decreasing blood cholesterol levels. Anti-oxidant properties of curcumin may also help prevent cardiovascular complications among diabetics.

2013 Dec 24
The administration of curcumin to diabetic rats normalized significantly their blood sugar level and TBARS values and increased the activities of all antioxidant enzymes and reduced glutathione concentration.

Curcumin prevents fatty diet induced obesity, fatty liver, dyslipidemia

FoodConsumer.org December 2013
Curcumin has bee known to prevent Alzheimer's disease, diabetes mellitus, skin cancer, diabetic foot ulcers, triple negative breast cancer, radiation dermatitis, fluoride-induced renal injury, Parkinson's disease, colorectal cancer, and heart failure.

Data from Affiliated Hospital Advance Knowledge in Cancer Gene Therapy

World Journal of Gastroenterology December 2013
Curcumin shows enhanced cytotoxicity toward PTEN-deficient cancer cells, suggesting that it might be a potential chemotherapeutic agent for cancers harboring PTEN mutations

High Cholesterol and Clogged Arteries May be Treated Naturally with Curcumin

Atlanta Blackstar, December 2013
Researchers found 26 percent fewer fatty artery deposits in the mice fed the curcumin-enhanced diet. Fewer atherosclerotic lesions were seen in these mice. In addition, the researchers found that curcumin seemed to actually change the expression of genes related to plaque buildup in arteries...After 18 weeks, the researchers found that just like lovastatin, curcumin lowered blood levels of cholesterol, triglycerides and LDL cholesterol, while increasing levels of HDL (“good”) cholesterol. It also led to changes in gene expression that could be expected to reduce the risk of artery damage and heart disease.“Long-term curcumin treatment lowers plasma and hepatic cholesterol and suppresses early atherosclerotic lesions comparable to the protective effects of lovastatin,” the researchers concluded. “The anti-atherogenic effect of curcumin is mediated via multiple mechanisms including altered lipid, cholesterol and immune gene expression.”

Curcumin prevents fatty liver

FoodConsumer.org December 2013
Curcumin has already been known to prevent obesity and diabetes mellitus in animal studies and human trials...Curcumin was found to suppress oleic acid induced lipid accumulation and lower triglycerides and total cholesterol levels...."These results indicated that curcumin has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability. In this report, we found curcumin exerted a regulatory effect on lipid accumulation by decreasing lipogenesis in hepatocyte. Therefore, curcumin extract may be active in the prevention of fatty liver."

Turmeric spice trial for depression

ioL Lifestyle December 2013
Previous research has shown curcumin acts on a compound called brain-derived neurotrophic factor (BDNF), which helps in the development and functioning of nerve cells.

Curcumin obliterates colon cancer cells

NaturalNews.com December 2013
Cancer cell death was observed through curcumin’s ability to reduce pro-caspase-3 levels, polymerase-1 cleavage and chromatin condensation. In a time- and dosage-dependent manner, curcumin caused wild-type p53 HCT-116 cells to self-destruct, while obliterating mutant p53 HT-29 cells in their tracks. The researchers were so astounded that they proposed that curcumin may actually have therapeutic potential in the management of colon cancer.

A Grocery Bag of Beneficial Antioxidants

HeatlhNewsDigest.com
Curcumin is found in the spice turmeric, the main spice used to prepare curry. Curcumin is thought to have antioxidant properties, as it may decrease swelling and inflammation. Preliminary research suggests that curcumin may prevent cancer and possibly slow the spread of cancer.

Curcumin as a regulator of epigenetic events.

HispanicBusiness.com December 2013
The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that enters into the composition of curry, already described for its diverse and broad biological activities, is nowadays well described as an inhibitor of DNA methyltransferase so that it is considered as a DNA hypomethylating agent...This dietary compound is able to restore the epigenetic regulation balance and appears as an attractive preventive and/or therapeutic approach against human cancer."

Turmeric spice could benefit those with Alzheimer’s disease

utSanDiego.com November 2013
Some research found that curcumin may help clear the amyloid plaques found in Alzheimer's disease. Other studies documented curcumin as a powerful anti-inflammatory that may have a role in the cure of Alzheimer’s. Some research has found curcumin to be a robust antioxidant, which helps ease Alzheimer's symptoms caused by oxidation and inflammation.

Curcumin, L-arginine and Vitamin E help diabetic foot ulcers

Foodconsumer.org November 2013
H.M. Maier from The Florida State University in Tallahassee, Florida, USA and colleagues reviewed studies and found evidence from animal studies indicating that curcumin, L-arginine and vitamin E as dietary supplements can help wound healing in people with type 2 diabetes mellitus.

Science Confirms Turmeric As Effective As 14 Drugs

ProHealth.com October 2013
Turmeric is one the most thoroughly researched plants in existence today.  Its medicinal properties and components (primarily curcumin) have been the subject of over 5600 peer-reviewed and published biomedical studies.  In fact, our five-year long research project on this sacred plant has revealed over 600 potential preventive and therapeutic applications, as well as 175 distinct beneficial physiological effects.

A natural alternative to antidepressants?

FoxNews.com October 2013
The compound curcumin is found in turmeric, a spice commonly used in the Indian curry. It’s packed with antioxidants, which help reduce inflammation and free radicals in the body, and now it may help to ease depression symptoms as well.

Curcumin dietary supplements help fight Alzheimer's disease

Foodconsumer.org October 2013
Curcumin has been known to have protective effects against cancer and type 2 diabetes mellitus.  It should not be a surprise that curcumin has antidiabetic and anticancer bioactivities because it is a polyphenol that may render the protection as an antioxidant against a range of disease-associated medical conditions including tumorigenesis, oxidation, inflammation, apoptosis and hyperlipemia. In addition to Alzheimer's disease and diabetes, taking curcumin dietary supplements may help prevent or treat multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, and psoriasis, according to early studies.

Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells.

2013;14(6):3449-53
Inhibitory effects of silibinin and curcumin, two herbal substances, on telomerase gene expression in breast cancer cells.

10 Top Foods To Boost Brainpower

Forbes.com October 2013
Turmeric, the spice that gives curry and mustard their yellow color, contains a chemical called curcumin that’s the subject of numerous neurologic studies right now. Research has shown curcumin’s ability to boost memory, slow the progression of Alzheimer’s and stimulate neurogenesis, which is the process of creating new brain cells. Studies suggest curcumin may also clear out amyloid plaques, the brain gunk thought to be a cause of Alzheimer’s, and calm inflammation of brain and nerve cells.

Curcumin Protects Against Lurking Dangers of Mercury Poisoning

NaturalNews.com October 2013
When the researchers administered daily oral curcumin treatments of 80 mg for three days, significant changes occurred. The mercury induced serum biochemical changes were reversed, as the liver and kidneys began showing signs of repair.

Is Turmeric As Effective As Fourteen Other Drugs? Sacred Plant’s Ingredient, Curcumin, Holds Key To Health Benefits
MedicalDaily.com October 2013
Curcumin -- have gained attention in both the medical and media worlds, due to research that points to the herb's preventative and therapeutic qualities for diseases like arthritis, Alzheimer's and even cancer.

Turmeric spice may have role in multiple myeloma therapy
OncologyNurseAdvisor.com October 2013
Curcumin, an active ingredient in the common kitchen spice turmeric, destroyed multiple myeloma cells in recent lab experiments.

Put Some Spice in Your Life
DocGiff.com October 5, 2013
Researchers have tested this spice as a cure for cancer and Alzheimer’s disease. It’s actually the cause of the yellow color, curcumin in turmeric, which interests scientists. Dr. Bharat Aggarwal, professor of cancer research at the Anderson Cancer Center in Houston, said curcumin induced a programmed death of cancer cells. In addition, it suppressed formation of new blood vessels that nourished tumors. Rats, for instance, got fewer cancers of the breast and colon when given curcumin.Researchers at Harvard went a step further and injected curcumin into the bloodstream of mice with Alzheimer disease-like plaques. A week later, studies showed a 30 percent decrease in these plaques. Research into how this spice affects humans with Alzheimer’s disease is only in preliminary stages.

No cure for Alzheimer’s disease, but curcumin may help
Foodconsumer.org October 2013

Epidemiological studies have shown that people who eat a diet high in curcumin were at a lower risk of Alzheimer's disease, suggesting that taking curcumin supplements may help prevent the disease. Indian studies have already suggested that a high dose of curcumin like 6 grams of curcumin per day can be used to prevent type 2 diabetes mellitus in people living with prediabetes.  Curcumin as an antioxidant has an antiinflammatory effect and may potentially help prevent a variety of cancer.

Curcumin was a component of the spice Tumeric, and had been shown to decrease the concentration of antioxidant defence substances within a cell.

Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo
Cancer Gene Therapy Week October 2013
Curcumin has strong reversal effects on the multidrug resistance of human colon carcinoma in vitro and in vivo.

Suppository of wisdom
Journal of Crohn's and Colitis October 2013
Curcumin enemas may be effective in controlling disease activity in ulcerative colitis.

Superfoods
ThirdAge.com September 2013
Canadian researchers reported that curcumin, found naturally in the spice turmeric, may have “antitumor activity” and “continues to receive considerable attention as a potent antioxidant and anti-cancer agent”. According to the Mayo Clinic, “At this time, there isn't enough evidence to recommend curcumin for preventing or treating cancer, but research is ongoing. Curcumin, a substance found in the spice turmeric, has long been used in Asian medicine to treat a variety of maladies. Now some research suggests that curcumin may help prevent or treat cancer.

Antitumor activity of novel curcumin analogs in hepatocarcinoma (HepG2) cells
Phys.org September 2013
Curcumin, a natural polyphenol of turmeric, continues to receive considerable attention as potent antioxidant and anti-cancer agent. Numerous analogues of curcumin have been synthesized and screened for their improved biological activities.

Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics
Int J Oncol.
2013 Sep
Curcumin, the principal bioactive component in turmeric, has demonstrated versatile capabilities to modify the therapeutic efficacy of a wide range of anticancer agents...Our results show that curcumin substantially improves the pharmacokinetics of PS leading to synergistic inhibition of the growth of human lung cancer xenografts, representing a promising drug combination.

Anti-cancer effects of docosahexaenoic acid and curcumin
BMC Cancer
September 2013
The combination of DHA and CCM is potentially a dietary supplemental treatment for some breast cancers, likely dependent upon the molecular phenotype of the cancer.

Sun-protective foods

FoxNews.com Chris Kilham Medicine Hunter, September 01, 2013
Turmeric root This yellow root contains a profoundly beneficial compound called curcumin that possesses superior anti-inflammatory activity, aids the immune system, enhances the brain, and protects your skin. Curcumin from turmeric is a very popular anti-inflammatory remedy. You can sprinkle turmeric on food, cook with it, or use curcumin supplements.

Curcumin-Induced Apoptosis of Breast Cancer Cells

Korean J Physiol Pharmacol. 2013 August
Curcumin (diferuloylmethane), a polyphenol derived from the plant turmeric (Curcuma longa Linn), is known for its antioxidant and anti-inflammatory properties. Moreover, quite a few studies, including our own, have shown that curcumin exhibits anticancer activities against various tumors, including pancreatic, colon, ovarian, and breast cancers, by modulating multiple signaling pathways. Curcumin has been reported to increase p53 signaling, which upregulates the transcription of downstream genes such as p21 and Bax to induce apoptosis in a variety of cancer cells. In addition, curcumin causes cancer cell apoptosis, in part via suppression of Notch1 signaling.

Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs

Korean J Physiol Pharmacol. 2013 August
long-term curcumin administration may reduce lung inflammation and fibrosis caused by radiation treatment.

Effects of curcumin on glucose metabolism in the brains of rats subjected to chronic unpredictable stress

BMC Complement Altern Med. August 2013
Curcumin was found to ameliorate the abnormalities in the behavior and brain glucose metabolism caused by CUS, which may account for its antidepressive effects.

Curcumin shows promise in hepatitis C

Curcumin as effective as Prozac in treating depression, without harmful side effects, Dallas researcher says


Curcumin can aid in many illnesses associated with inflammation, from cancer to arthritis, and even Alzheimer’s disease. Now he has a study, published in July’s Phytotherapy Research, that suggests curcumin is just as effective as Prozac, an anti-depressant fluoxetine, in treating clinical depression.

Effects of curcumin on glucose metabolism in the brains of rats subjected to chronic unpredictable stress

BMC Complementary and Alternative Medicine 1 August 2013
Curcumin was found to ameliorate the abnormalities in the behavior and brain glucose metabolism caused by CUS, which may account for its antidepressive effects.

Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.

2013 Jul
This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with major depressive disorder.

“SPICE UP YOUR HEALTH” The Solid Science of Turmeric and Curcumin

NYSE Post
Many studies now prove that turmeric/curcumin contain over 150 potentially therapeutic traits, which include antioxidant, anti-inflammatory and anti-cancer properties. Remarkably, curcumin is capable of crossing the blood-brain barrier, which is one reason why it holds promise as a neuroprotective agent in a wide range of neurological disorders. Researchers have investigated curcumin for its potential role in improving Parkinson’s disease as well.  Studies have shown that it may even hold more promise than the drugs currently used for this disorder. 

The Healing Powers of Curcumin

Charles Poliquin

The many healing properties of curcumin are some of the most exciting discoveries in the field of functional medicine. Curcumin counters inflammation, detoxifies excess estrogen, supports the body’s antioxidant system, helps deal with abnormal blood fat ratios (dyslipidemia) and offers protection against colds and flu.

Kitchen spice as good as some prescriptions

eMaxHealth-by Kathleen Blanchard-Jul 14, 2013
Health benefits of curcumin in the spice turmeric include, but may not be limited to the following, based on research studies.Liver health, Heart health, Pain relief,  Colon cancer, Breast cancer prevention, Alzheimer’s disease, Obesity, Dental health, Acne,
Depression

Can Turmeric Relieve Pain? One Doctor's Opinion

TIME-Jul 4, 2013
Four in the morning, four more at night. That's eight big mustard-yellow capsules every day. They contain nothing but turmeric, a spice. But for ...

Curcumin Provides Long-Term Protection Against Lung Damage ...

Science World Report-Jul 3, 2013
An interesting study on 'turmeric,' one of the key ingredient in many Asian dishes, reveals that curcumin, a naturally occurring compound in ...

Role of curcumin in radiation therapy

Oncology Nurse Advisor-Jul 2, 2013
Can curcumin (the main component of turmeric) help minimize side effects related to radiation therapy
 

Why Turmeric Might Just Be The Healthiest Spice Of All Time

Refinery29-June 25, 2013
Turmeric is anti-viral, anti-fungal, and anti-inflammatory. Inflammation is the root of many chronic diseases that cause our health to deteriorate — and curcumin...

The dust mite allergy is one of the leading triggers of breathing ...

Daily Mail-June 17, 2013
New research shows the spice curcumin can ease symptoms in benign prostatic hyperplasia, an age-related non-cancerous condition which affects around 2.5 ...

Find relief from those joint pains

Times of India-by Debarati S Sen-Jun 13, 2013
A recent research claims that curcumin, a compound of haldi, can relieve pain in ... Curcumin is the principal curcuminoid of the popular Indian spice turmeric.

Curcumin as a regulator of epigenetic events

Molecular Nutrition & Food Research 2013 June
The polyphenolic compound curcumin (diferuloylmethane), a yellow spice that enters into the composition of curry, already described for its diverse and broad biological activities...is able to restore the epigenetic regulation balance and appears as an attractive preventive and/or therapeutic approach against human cancer.

Curcumin, Anti-Oxidant, and Pioglitazone Therapy with Inclusion of Vitamin E in Non Alcoholic Fatty Liver Disease

Gut 2013 June
Curcumin is a pan-antioxidant with anti-inflammatory, anti-apoptotic, anti-microbial, and anti-fibrogenic properties...This study postulates the effects of Curcumin plus vitamin E in NAFLD may prevent NASH with a modest anti-fibrotic effects and necroinflammatory score; with impressive changes in adipokines levels. Additive effects of Curcumin with vitamin E has significant effects on Serum lipids and insulin sensitivity. Unavailability of Pre and post liver biopsy was the limitation A large control trial needs to validate..

Curcumin Shows Antiaging Potential in New Studies

eMaxHealth-by Deborah Mitchell- June 14, 2013
If you like curried food, then you may be fighting aging while you eat. Two new studies suggest that curcumin, the ingredient in turmeric that ...

Breast Cancer News: Curcumin relieves radiation dermatitis

Food Consumer-June 10, 2013
Monday June 19, 2013 (foodconsumer.org) -- A new study in Radiation Research suggests that women who are diagnosed with breast cancer ...

Spicing it Up with Turmeric: Health Benefits, Tips, and Recipes

One Green Planet-May 31, 2013
Turmeric is full of powerful antioxidants, including curcumin, which are known to fight cancer-causing free radicals. Most research done on the ...

Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus

Phytomedicine 2013 June
Curcumin, a natural polyphenolic flavonoid isolated from the rhizome of a plant, Curcuma longa Linné., has been found to possess many beneficial biological activities. The aim of this study was to investigate the synergistic effect of curcumin and antibiotics as well as to determine the antibacterial activity of Curcumin against specific MRSA strains.

Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumor cells

J Cell Biochem. 2013 June
Curcumin, a polyphenolic compound isolated from Curcuma longa (Turmeric) is widely used in traditional Ayurvedic medicine. Its potential therapeutic effects on a variety of diseases have long been known. Though anti-tumour effects of curcumin have been reported earlier, its mode of action and telomerase inhibitory effects are not clearly determined in brain tumour cells. In the present study, we demonstrate that curcumin binds to cell surface membrane and infiltrates into cytoplasm to initiate apoptotic events.

Curcumin prevents obesity, diabetes and fatty liver

Food Consumer 2013 May
Curcumin an ingredient found in turmeric has been used to prevent many chronic diseases including obesity, type type 2 diabetes and liver disease.  Recent studies show that this dietary supplement possesses potent antioxidant, anticarcinogenic, antiinflammatory and hypoglycemic properties.

Citrus limonoids and curcumin additively inhibit human colon cancer cells

Food Funct. 2013 April
This study provides compelling evidence of the pharmacodynamic additive effect of limonoids and curcumin in inhibiting human colon cancer cells. These results suggest that consumption of curcumin and limonoids together may offer greater protection against colon cancer.

Antidepressant-Like Effects of Curcumin

CNS Neurol Disord Drug Targets. 2013 April
Curcumin, the major constituent of the spice turmeric produces a plethora of biological actions that have translated in vivo into behavioral and neurochemical effects in rodents that are also produced by clinically-used antidepressants.

Curcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMPK

Basic Clin Pharmacol Toxicol. 2013 April
Curcumin is a well-known component of traditional turmeric (Curcuma longa), which has been reported to prevent obesity and diabetes. The levels of total cholesterol, fasting glucose and insulin in serum were decreased, and HFD-induced impairment of insulin sensitivity was improved by curcumin supplementation

Curcumin inhibits UVB

Exp Dermatol. 2013 April
Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities.... Curcumin prevented UVB-induced MMP expression

Curcumin improves spatial memory and decreases oxidative damage in aged female rats

Biogerontology. 2013 April
Curcumin is the active component of curcuma longa and has shown antioxidant, antiinflamatory and neuroprotective properties...curcumin supplementation improves cognitive functions by decreasing the lipid peroxidation in brain tissue of aged female rats.

Curcumin And Curcumin-Like Molecules: From Spice To Drugs

Curr Med Chem. 2013 April
Curcumin is the major yellow pigment extracted from turmeric, a commonly used spice in Asian cuisine that is used extensively in ayurvedic herbal remedies. A number of studies have shown that curcumin can be a prevention agent and a chemotherapeutic agent for colon, skin, oral and intestinal cancers. Curcumin is also well-known for its anti-inflammatory and antioxidant properties, showing high reactivity towards peroxyl radicals, and thus acting as a free radical scavenger.

Genetic And Epigenetic Studies For Determining Molecular Targets Of Natural Product Anticancer Agents

Curr Cancer Drug Targets. 2013 April
Accumulating evidence has demonstrated that some common natural products (such as epigallocatechin-3-gallate (EGCG), curcumin, genistein, sulforaphane (SFN) and resveratrol) have anticancer properties through the mechanisms of altering epigenetic processes and targeting cancer stem cells (CSCs). These bioactive compounds are able to revert epigenetic alterations in a variety of cancers in vitro and in vivo. They exert the anticancer effects by targeting various signaling pathways related to the initiation, progression and metastasis of cancer. It appears that natural products hold great promise for cancer prevention and treatment by altering various epigenetic modifications.

Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin

Mol Cell Biochem. 2013 April
Curcumin, a phytochemical, has a wide variety of biological actions including anti-inflammatory and antioxidative....the formation of protein carbonyls in the liver of the aging mice can be prevented by the antioxidative effects of melatonin and curcumin, which may provide health benefits in aging animals.

Curcumin inhibits invasion and metastasis in K1 papillary thyroid cancer cells

Food Chem. 2013 April
Curcumin, the active constituent of dietary spice turmeric, possesses a strong potential for cancer prevention and treatment...The findings showed that curcumin might be an effective tumouristatic agent for the treatment of aggressive papillary thyroid carcinomas.

Neuroprotection by curcumin in ischemic brain injury

PLoS One. 2013 April
Curcumin administration significantly reduced infarct size. Curcumin also markedly reduced oxidative stress levels in middle cerebral artery occlusion (MCAO) rats; Taken together, these findings provide evidence that curcumin protects neurons against ischemic injury, and this neuroprotective effect involves the Akt/Nrf2 pathway. In addition, Nrf2 is involved in the neuroprotective effects of curcumin against oxidative damage.

Anti-Obesity Agents Have the Potential to Inhibit Fat Gain Right at the Cellular Level

Suppversity 2013 April
The stimulatory effect curcumin exerts on the AMPK expression of adipocytes results in a down-regulation of PPAR-gamma in 3T3-L1 adipocytes

Supplement Your Health With Curcumin

Wayne County Journal Banner 2013 April
Curcumin may have the power to ease inflammation, promote healthy cell growth, protect against ... The main bioactive compound in turmeric is called curcumin.

Curcumin is a complete well-being tonic – it benefits every organ in the body… It shows promise of fighting nearly every disease

Marks Daily Apple 2013 April
Curcumin Controls Blood Sugar: It switches on the liver genes that keep glucose levels in check. It improves the pancreas’s ability to make insulin and helps slow down the metabolism of carbohydrates after meals. Curcumin Fights Cancer: It inhibits the genetic switches that allow for cancerous cell growth to occur. Curcumin Speeds Up Metabolism: USDA research shows that is enhances cellular energy to speed metabolism. Curcumin Clears Plaque: It removes amyloyd plaque buildup in the brain that can cause Alzheimer’s.
  • The anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases
    Eur J Nutr. 2011 Apr;50(3):151-61. Epub 2011
    School of Life Sciences, College of Natural Sciences
    Researchers reviewed the last ten years of curcumin science as it applies to supporting weight loss and preventing obesity-related disease. Their conclusion is, “The modulation of several cellular transduction pathways by curcumin has recently been extended to elucidate the molecular basis for obesity and obesity-related metabolic diseases. These findings might enable novel phytochemical treatment strategies as well as curcumin translation to the clinical practice for the treatment and prevention of obesity-related chronic diseases. Furthermore, the relatively low cost, safety and proven efficacy of curcumin make it advisable to include curcumin as part of healthy diet.”

    Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
    Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.
     

  • Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern target- Bokyung Sung 
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor κB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail.Trends Pharmacol Sci. 2009 Feb;30(2):85-94. Epub 2008 Dec 26
    Spice Rack...Or Medicine Chest?
    Nutrition Action Health Letter
    "Curcumin protects the brain cells in every animal model of traumatic brain injury, whether it's stroke, Alzheimer's disease, Huntington's disease, or mad cow disease," says Gregory Cole, associate director of the Alzheimer's Disease Center at the University of California, Los Angeles. "What's unique about Curcumin," Cole notes, "is that it binds directly to beta-amyloid deposits in the brain and reduces their size." Beta-amyloid is a protein fragment that builds up between brain cells of people with Alzheimer's disease....
    Science Daily Magazine
    How Plants Protect Us From Disease
    "Everyday foods, beverages, and spices contain healthful compounds that help us fight harmful inflammation. And, in doing that, these phytochemicals may also reduce our risk of diseases associated with chronic inflammation, including cancer and diabetes."
    Curcumin Curry Power
    Science News Magazine
    "The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive."

    Health: The Fires Within
    Time Magazine
    Chronic inflammation may be the engine that drives many of the most feared illnesses of middle and old age. This concept is so intriguing because it suggests a new and possibly much simpler way of warding off disease. Instead of different treatments for, say, heart disease, Alzheimer's and colon cancer, there might be a single, inflammation-reducing remedy that would prevent all three.

    Science Daily Magazine
    Did evolution give us inflammatory disease?
    Researchers demonstrate that some variants in our genes which could put a person at risk for inflammatory diseases -- such as multiple sclerosis, Crohn's disease or rheumatoid arthritis -- have been the target of natural selection over the course of human history.
    The 'inflammation theory': Immune-system errors linked to more illnesses
    The Seattle Times
    "Medical researchers are becoming increasingly convinced that the most primitive part of the immune system (inflammation), may play a crucial role in some of the most devastating afflictions of modern humans, including heart disease, cancer, diabetes and possibly Alzheimer's."

    Obesity is Inflammatory Disease, Rat Study Shows
    Sci-News.com
    "
    Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans. PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself."

    Did evolution give us inflammatory disease?
    American Journal of Human Genetics
    Researchers demonstrate that some variants in our genes that could put a person at risk for inflammatory diseases such as multiple sclerosis, Crohn's disease or rheumatoid arthritis, have been the target of natural selection over the course of human history. The findings suggest that in the past these variants rose in frequency in the human population to help protect us against viruses, bacteria and other pathogens. But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely.
    Curcumin at M.D. Anderson Cancer Center
    The University of Texas, MD Anderson Cancer Center
    Curcumin has been shown to prevent a large of number of cancers in animal studies. Laboratory data indicate that Curcumin can inhibit tumor initiation, promotion, invasion, angiogenesis and metastasis. Epidemiological evidence indicate that incidence of certain cancers is less in people who consume Curcumin than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and anti-inflammatory effects at M. D. Anderson Cancer Center and other medical institutions.
    Curcumin Spice Healer
    Scientific American Magazine
    An ingredient in curry shows promise for treating Alzheimer's, cancer and other diseases.
    "A chapter in a forthcoming book, for instance, describes the biologically active components of Turmeric--Curcumin and related compounds called Curcuminoids--as having antioxidant, anti-inflammatory, antiviral, antibacterial and antifungal properties, with potential activity against cancer, diabetes, arthritis, Alzheimer's disease and other chronic maladies. And in 2005 nearly 300 scientific and technical papers referenced Curcumin in the National Library of Medicine's PubMed database, compared with about 100 just five years earlier. Scientists who sometimes jokingly label themselves Curcuminologists are drawn to the compound both because of its many possible valuable effects in the body and its apparent low toxicity. They ponder how the spice or its derivatives might be used, not just as a treatment but as a low-cost preventive medication for some of the most feared ailments. As a treatment, it also has some enticing attributes. Because Curcumin targets so many biological pathways, it could have benefits for cancer therapy: malignant cells may be slow to acquire resistance to it and so might have to go through multiple mutations to avoid the substance's multipronged attack." 1 2 3 4
  •   Previous news and studies on Curcumin and Turmeric.
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      Scientific journals with published studies of Curcumin and Turmeric.

    American Journal of Physiology - 277: 320-29
    Age - 18:167-9
    Agents and Actions - 28:298-303
    Alimentary Pharmacology and Therapeutics - 13(2):245-249
    Alternative Medicine Review - 4(3):178-88, 6(2):167-187, 7(5):404-9
    American Journal of Clinical Nutrition - 64(5):761-766
    American Journal of Physiology: Gastrointestinal and Liver Physiology 284(1):85-95, 284(2):321-7
    American Surgeon - 64(1):47-51
    Annals of the New York Academy of Sciences - 973:250-4
    Anticancer Drugs - 8(5):470-81
    Anti Cancer Research - 11: 593-596,  19(5A):3675-80, 20(3a):1733-8,

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      What is Turmeric-Curcumin.com?

    Turmeric-Curcumin.com is our company and website, dedicated since 2000 to offering the highest quality Curcumin 95% extract, the best customer service, the lowest prices in the industry, and none of the marketing hype. Unlike other suppliers, we do not sell 500 products, or even 5 products. We remain dedicated and focused on the most powerful, healthful and important compound in botanical medicine; Curcumin, concentrated and standardized to 95% purified extract. This extraordinary spice extract has generated such interest that universities and medical centers around the world are continually conducting research studies and discovering new benefits, with multiple ongoing human clinical trials. Due to it's potent antioxidant power, Curcumin has been recognized as one of the most promising food-derived compounds in fighting a variety of degenerative diseases. The scientific evidence remains overwhelming, demonstrating the many health benefits via in vitro, in vivo and human clinical studies. You will receive 100% additive free products; no sugars or other sweeteners, no artificial colors or flavors, no starch, no sodium, no soy, no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa corporation), no GMO, no dyes, no gums or any other unnecessary compounds. You may contact support@turmeric-curcumin.com or call with any questions or comments and we will respond as quickly as possible.

     

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