What is Turmeric and Curcumin?
Turmeric is a member of the Curcuma botanical group, which is part of the ginger family of herbs, the Zingiberaceae. The root and rhizome stem of the Curcuma longa plant is crushed and powdered into ground Turmeric spice. Ground Turmeric is used worldwide as a seasoning and is the source of extracted Curcumin.

"One of the greatest beneficial medicinal plants in the entire world...one of the most researched medicinal plants in history.” - Chris Kilham. Curcumin is a natural component of the rhizome of Turmeric and one of the most studied phytochemicals in science. Turmeric contains approximately 3% Curcumin, which is extracted until it is 95% pure to be researched or supplemented.


  What are the researched properties of Curcumin? 

"As of January 2015, there are nearly 5,000 studies and articles on Curcumin or Turmeric listed in the National Institutes of Health PubMed database." - Fox News, 2015

"More than 7000 published articles have shed light on the various aspects of curcumin including its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer activities." - Food and Chemical Toxicology, 2015

"PubMed.com, a research database maintained by the National Institutes of Health, lists 7,728 studies involving curcumin and another 3,205 studies involving turmeric, with the large majority focused on their effectiveness against multiple medical conditions." - Post Gazette, 2015

"Curcumin alone has been subject to more than 1,000 studies in 2014." - Natural Products Insider, December 2014

"More than 6.000 articles published within the past two decades have discussed the molecular basis for the antioxidant, anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer activities assigned to this nutraceutical.- MD Anderson Cancer Center, Houston, TX, December 2014

"Curcumin has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. - Cancer Research and Treatment, 2014

"Over 100 clinical trials on curcumin in various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer." - Cytokine Research Laboratory, The University of Texas, December 2014

"Extensive research over the past 30 years has shown that Curcumin plays an important role in the prevention and treatment of various pro-inflammatory chronic diseases including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and malignant diseases." - Cancer Research and Treatment, 2014

"Curcumin is the most widely-studied plant-derived medicinal chemical in modern science...based on a statistical analysis of over three million published scientific studies, Curcumin is the most frequently mentioned phytonutrient." - NaturalNews.com, 2013

"The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive." - Science News Magazine

  Where can I purchase Curcumin?
Order direct from Turmeric-Curcumin.com, the largest supplier of Curcumin supplements at wholesale prices to the general public, research institutions, physicians, and university medical centers since 2000. Quality control tests, laboratory analysis certification, and rigorous cGMP manufacturing standards all ensure freshness, potency, and purity of content material. Orders are shipped FedEx or USPS Priority for fast and secure delivery. Contact support@turmeric-curcumin.com for bulk ordering, private labeling or any other questions. Multiple bottle orders will receive quantity discounts listed below, 12-bottle case purchases will also receive free US shipping.


  500 mG OF Curcumin 95% extract per capsule.

Health-conscious consumers should be careful in selecting a Curcumin extract product, specifically knowing the difference between Curcumin and Turmeric. Consumers may be misled by deceptive labels, believing there is much more true Curcumin extract in a product than there really is. Some examples of these misleading claims make it difficult to tell how much active Curcumin extract is actually included, because they are substituting Turmeric spice powder, which averages only 3% Curcumin by weight. - 55(2):126-31. Some examples of these deceptions are:

"Doctors Turmeric Curcumin" on the front of the label, but checking the ingredient finds that each capsule is 100% Turmeric (curcuma longa), a common and inexpensive spice found in supermarkets and grocery stores.

"500 mg Enhanced Formula" but only contains 200 mg Curcumin extract, and the remainder is 300 mg Turmeric spice.

"1000 mg Super Complex Curcumin (25%)" which is actually only 250 mg of Curcumin extract and the remaining 750 mg is Turmeric spice.

"1000 mg per serving" but one serving size is 4 capsules, 250 mg each.

These deceptions are not uncommon in the supplement industry, even by the largest vitamin shops. The solution is to compare. Our label clearly indicates the contents (Curcumin extracted from Turmeric root), the purity concentration (95%) and the amount (500mg) for each capsule, not per serving. Our product contains 500 milligrams per capsule of 95% standardized Curcumin extract. Our extract is standardized to contain a minimum of 95% Curcuminoids: Curcumin (C), Demethoxycurcumin (DMC), Bisdemethoxycurcumin (BDMC) - the complete range in their natural composition ratio of 76:19:5. Thus, in our product the full spectrum of Curcumin antioxidant Curcuminoids are extracted from Turmeric (Curcuma longa root) and represented in their natural arrangement for maximum potency. This is the same material used in clinical trials and medical studies, free of added chemicals, 'enhancements', or treatments. Unlike many antioxidants, Curcumin is capable of both preventing free radical formation, as well as neutralizing existing free radicals, and is considered an effective bioprotectant due to this dual activity. We supply the purest Curcumin available, standardized to minimum 95% extract.There is no claimed "enhancing" material to fill the capsule up and lower the Curcumin percentage. Our product contains no starch, nosugars or sweeteners, no artificial colors or flavors, no sodium, no soy, no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa corporation), no GMO, no dyes, no gums.


  200 capsules per bottle.

For the environment as well as your finances, we don't require purchasing two or three bottles to obtain 200 capsules. Each bottle contains the full 200 capsules, with every 12-bottle case totaling over two and a half pounds of pure Curcumin extract. The suggested serving size is one (1) to four (4) capsules with each meal, preferably with beneficial oils and fats, potentially offsetting the inflammatory response process that occurs during ingestion and digestion.

  Are there side effects of Curcumin or Turmeric?

Turmeric has been used in large quantities as a condiment for thousands of years with no adverse reactions. The US FDA classifies Turmeric as GRAS (Generally Recognized As Safe). Pregnant women, individuals with gallstones or using blood thinners should consult a health care provider before using herbs or dietary supplements in amounts greater than usually found in foods.

"Curcumin is not toxic to humans up to 8,000 mg/day."- Phase I Clinical Trial of Curcumin, Anticancer Res. 21(4B):2895-900. 

"Patients received 8 g curcumin by mouth daily...No toxicities were observed." -  Phase II ClinicalTrial of Curcumin, Clin Cancer Res. 14(14):4491-9.

"Curcumin, even in large quantities, does not produce any known side effects in humans." - Blood.101(3):1053-62.


  Has the absorption Curcumin 95% been studied?

In most studies Curcumin 95% has been delivered orally whether the subject is human or animals. This orally delivered Curcumin 95% extract showed several biological effects such as antioxidant, anti-inflammatory, antidiabetic, and anticancer beneficial effects in several types of cancer in patients.

"Orally administered curcumin inhibited inflammatory cytokines such as TNF, cyclooxygenase (COX)-2, inducible nitric oxide synthase in mice indicating its anti-inflammatory activity and further suppressing dextran sodium sulfate-induced colon carcinogenesis." - Biofactors. 2013

"Clinical trials have shown that orally delivered curcumin inhibited inflammatory molecules." - AAPS Journal. 2013

  Has the bioavailability of Curcumin 95% been studied?
"In a human clinical trial, 3.6 g of Curcumin via oral route was found to produce a plasma curcumin level of 11.1 nmol/L after an hour of dosing." - Clin Cancer Research.

"The average peak serum concentrations after taking 4,000 mg, 6,000 mg and 8,000 mg of curcumin were 0.51 microM, 0.63 microM and 1.77 microM, respectively." - Phase I Clinical Trial of Curcumin, Anticancer Research

"Traces of curcumin were detected in the plasma. Its concentration in the small intestinal mucosa, between 39 and 240 nmol/g of tissue, reflects differences in dietary concentration...The comparison of dose, resulting curcumin levels in the intestinal tract, and chemopreventive potency suggests tentatively that a daily dose of 1.6 g of curcumin is required for efficacy in humans." - Journal Cancer Epidemiol Biomarkers.

"The concentrations of curcumin in normal and malignant colorectal tissue of patients receiving 3,600 mg of curcumin were 12.7 +/- 5.7 and 7.7 +/- 1.8 nmol/g, respectively...The results suggest that a daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut." - Cancer Epidemiol Biomarkers Prev.

  Are there any natural Methods of INCREASing bioavailability?
"Buttermilk could be used as a carrier for curcuminoids especially if delivered with food...The most important and practical finding from the bioaccessibility data is that the incorporation of powdered curcuminoids with buttermilk results in a 15-fold increase in bioaccessibility of curcuminoids." - Food Chemistry, July 2015

  What are the pharmacological actions of Curcumin?

Cancer (46), Ovarian cancer (42), pituitary (41), Tumor (40), Cirrhosis (39), radiation (38), blood (38), Inflammatory (37), colon cancer (37), prostate (37), Cytotoxicity (36), Melanoma (36), Hypothyroid (36), prostate cancer (36), Colitis (36), Anti-Inflammatory (35), Chemopreventive (34), breast cancer (34), Seizures (34), HPV (34), Antiviral (34), Granuloma (34), Pulmonary fibrosis (33), Leukemia (33), Osteosarcoma (33), Apoptotic (33), diabetes (34), Allergy (33), endometriosis (33), skin (33), Antioxidants (33), Squamous cell carcinoma (33), Liver damage (32), Colorectal cancer (32), chemotherapy (32), lymphoma (32), neurons (32), Neuroprotective (32), Anti-Apoptotic (32), Antimicrobial (32), Oxidant (32), Neurogenesis (32), Gastric cancer (32), Schistosomiasis (31), Neuroblastoma (31), Sepsis (31), Death (31), Emphysema (31), alzheimer's (31), Proteasome Inhibitors (31), Hepatoma (31), cartilage (31), Cytotoxic (31), Antifungal (33), spinal cord (31), Pancreatitis (30), Anti-Tumor (30), Antiproliferative (30), Tumorigenic (30), arthritis (30), dementia (30), Periodontal disease (30), Cardiovascular (30), Contraceptive (30), Insulin Resistance (30), Radiosensitizer (30), Multiple myeloma (30), Cyclooxygenase Inhibitors (30). Helicobacter pylori infection (30), Myeloma (30), Cervical tumor (30), Diabetic nephropathy (29), Herpes simplex (29), Dopaminergic (29), Telomerase Inhibition (29), Cell cycle arrest (29), Serotonergic (29), pain (29), Immunomodulatory (29), Genotoxic (29), flu (29), Bladder tumor (29), Proliferative (29), Carcinogenic (29), Caspase-3 Activation (29), hepatic injury (29), Chemotherapeutic (29), Meningitis (29), Anxiety (28), Atherosclerosis (28). Uveitis (28). Parkinson's disease (28), Gastroprotective (28), Testes (28), Inflammatory Bowel Disease (28), hypothalamus (28), Chronic Renal Failure (28), cervical cancer (28), Human papillomavirus (28), COPD (28), Carcinogen (28), NF-kappaB Inhibitor (28), Hepatocellular carcinoma (27), Cataractogenic (27), cystic fibrosis (27), Sarcoma (27), Immune system (27), Chemosensitizer (27), Anti-Angiogenic (27)Small intestine (27), Antineoplastic (27), Osteoarthritis (27), Chondroprotective (26), Mesenteric Ischemia (26), Oxidants (26), Imbalance (26), Phototoxicity (26), Fever (26), chronic fatigue (26), Encephalitis (26), hepatitis (26), Hepatitis C (26), Hypoglycemic (26), Hematologic (26), Diabetic retinopathy (26), Hodgkin's lymphoma (25), Ulcerative colitis (25), anemia (25), Vitiligo (25), Uncoupling (25), Bile duct cancer (25), Parkinsonism (25), Hematopoietic (24), Atrioventricular (24), Cholinergic (24), Subarachnoid Hemorrhage (24), HIV (24), Anti-Proliferative (24), Prostatitis (24), Glycine (31), Anti-Bacterial (23), Anti-Ulcer (23), liver disease (23), Hyperthyroidism (23), Tongue (23), Hepatoprotective (23), Ewing's sarcoma (23), Stroke (23), Malaria (23), Hepatitis B (22), depression (21), Amnesia (21), Dopamine (20), pharynx (19), Leptin resistance (17)

  How may Curcumin work against cancer?
Studies on Curcumin and Cancer. Independent research studies on suggest that Curcumin has the potential for treatment of cancers including colon, breast, prostate, lung, skin and bowel. The ability of curcumin to regulate a variety of signaling pathways involved in cell growth, apoptosis, invasion, metastasis, and angiogenesis in preclinical studies elicited scientific interest in its potential as an anticancer agent in tumor therapy. Curcumin is one of the most powerful and promising chemopreventive and anticancer agents, and epidemiological evidence demonstrates that people who incorporate high doses of this spice in their diets have a lower incidence of cancer. Curcumin's epigenetic modulation has been studied by the US National Cancer Institute (NCI) and academic investigators around the world. Because of low toxicity and great efficacy in multiple in vitro and in vivo cancer models, Curcumin was selected for further development, put through extensive toxicology testing and has successively made it through the first stages (Phase I) of clinical testing abroad and is currently in clinical trials at several sites in the U.S. Numerous mechanisms have been described for the anticancer activity of Curcumin. Researchers at M.D. Anderson Cancer Center in Houston, TX state that Curcumin has “enormous” potential to prevent and treat cancer. Curcumin was able to suppress tumor formation, growth, and even metastasis according to their review. Currently, there are clinical trials being conducted on the effects of Curcumin on patients with bowel cancer. According to the American Cancer Society, tests have shown that curcumin can kill cancer cells in laboratory dishes, and also slow the growth of the surviving cells. Furthermore, it has been found to reduce the development of several forms of cancer in lab animals, while also shrinking various animal tumors. A 2003 review - Anticancer Potential of Curcumin: Preclinical and Clinical Studies - in Anticancer Research concluded that, "…it is quite apparent that curcumin has tremendous potential for prevention and therapy of various cancers." Another study on the role of curcumin in cancer therapy found that, "Research over the last few decades has shown that curcumin is a potent anti-inflammatory agent with strong therapeutic potential against a variety of cancers. Curcumin has been shown to suppress transformation, proliferation and metastasis of tumors," and called for additional and larger controlled studies to determine its full potential. Inhibition of proliferation of tumor cells, induction of apoptosis (a mode of cell death), inhibition of transformation of cells from normal to tumor, inhibition of invasion and metastasis and suppression of inflammation have been linked with the activity of Curcumin. Down-regulation of COX2, 5-LOX, adhesion molecules, inflammatory cytokines, chemokines, growth factor receptors, vascular endothelial growth factor (VEGF) and transcription factors by Curcumin have been linked to its antitumor activity. Curcumin also has been studied with regards to the core inflammatory gene signal, NF-kappaB,resulting in a beneficial domino effect throughout the body. One benefit of this domino effect is a direct reduction in the risk of cancer from overweight-induced inflammation. ollowing DNA damage, the cell cycle can be transiently arrested to allow for DNA repair or for activation of pathways leading to programmed cell death (apoptosis) if the damage is irreparable. Defective cell-cycle regulation may result in the propagation of mutations that contribute to the development of cancer. Unlike normal cells, cancer cells proliferate rapidly and are unable to respond to cell death signals that initiate apoptosis. Curcumin has been found to induce cell-cycle arrest and apoptosis by regulating a variety of cell-signaling pathways (3, 41-45). For example, the inhibition of cell proliferation by curcumin has been associated with the Nrf2-dependent downregulation of DNA repair-specific flap endonuclease 1 (Fen1) in breast cancer cells in culture. Curcumin has been shown to induce p53-dependent or -independent apoptosis depending on the cancer cell type. In a panel of cancer cell lines, p53-independent apoptosis induced by curcumin was mediated by the rapid increase of ROS and the activation of MAPK and c-jun kinase (JNK) signaling cascades. Inhibition of NF-κB signaling by curcumin also suppresses proliferation and induces apoptosis in cancer cells. Inhibition of tumor invasion and angiogenesis Malignant and aggressive forms of cancer can invade surrounding tissues and spread to distant tissues once cancer cells have acquired the ability to leave the primary site (reduced cell-to-cell adhesion and loss of polarity), migrate, and disseminate. Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells acquire the ability to migrate and invade through downregulating proteins like E-cadherin and γ-catenin and expressing mesenchymal markers like MMPs, N-cadherin, and vimentin. In breast cancer cells, curcumin prevented EMT-associated morphological changes induced by lipopolysaccharide (LPS) while upregulating E-cadherin and downregulating vimentin. It was further shown that curcumin inhibited NF-κB/Snail signaling involved in LPS-induced EMT. In another study, curcumin increased the expression of the small non-coding RNA miR181b, which then downregulated proinflammatory cytokines, CXCL1 and CXCL2, as well as MMPs, thereby reducing the metastatic potential of breast cancer cells. Curcumin inhibited IL-6-induced proliferation, migration, and invasiveness of human small cell lung cancer (SCLC) cells by reducing JAK/STAT3 phosphorylation (i.e., activation) and downstream genes coding for cyclin B1, survivin, Bcl-XL, MMPs, intercellular adhesion molecule 1 (ICAM-1), and vascular endothelial growth factor (VEGF). Curcumin was found to exert its anticancer activities in many different types of cancer cells by regulating a variety of signaling pathways. Combining curcumin with anticancer drugs like gemcitabine in pancreatic cancer, docetaxel in breast cancer, and imatinib in chronic myeloid leukemia may be safe and well tolerated. A recent single-arm, phase II trial combining three cycles of docetaxel/prednisone and curcumin (6 g/day) was carried out in 26 patients with castration-resistant prostate cancer. The level of prostate-specific antigen (PSA) was decreased in most patients and was normalized in 36% of them, and the co-administration of curcumin with drugs showed no toxicity beyond adverse effects already related to docetaxel monotherapy. Many registered phase I/II clinical trials designed to investigate the effectiveness of curcumin alone or with first-line treatment in patients with breast, prostate, pancreatic, lung, or colorectal cancer are under way.
  How may Curcumin work against arthritis?
Arthritis is also a proinflammatory disease. Curcumin's anti-inflammatory properties also make it a strong candidate for treating inflammatory diseases such as osteoarthritis. A 2014 study in the Clinical Interventions in Aging found that curcumin extracts "were as effective as ibuprofen for the treatment of knee osteoarthritis." All current drugs approved for arthritis have anti-inflammatory activity. Anti-TNF (tumor necrosis factor) therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production, block the action of TNF, and have activity against arthritis. When inflammation is reduced, the added benefit is pain relief. A double-blind, crossover study showed that Curcumin may be  effective in relieving pain and improvements in morning stiffness, walking time, and joint swelling. A preliminary intervention trial that compared curcumin with a nonsteroidal anti-inflammatory drug (NSAID) in 18 patients with rheumatoid arthritis (RA) found that improvements in morning stiffness, walking time, and joint swelling after two weeks of curcumin supplementation (1.2 g/day) were comparable to those experienced after two weeks of phenylbutazone (NSAID) therapy (300 mg/day). In a more recent randomized, open-label study in 45 RA patients, supplementation with a mixture of all three major curcuminoids (0.5 g/day for eight weeks) was found to be as effective as diclofenac (NSAID; 50 mg/day) in reducing measures of disease activity, tenderness, and swelling joints.
  How may Curcumin work against Crohn's disease and Ulcerative Colitis?
Crohn’s disease is also a pro-inflammatory disease. All current drugs approved for this disease have anti-inflammatory activity. Anti-TNF therapy has been approved for this disease. Curcumin has been shown to both suppress the TNF production and the TNF action. Curcumin taken orally has been shown to have activity against inflammatory bowel disease. Study results suggest that Curcumin could have a protective role in ulcerative colitis via regulation of oxidant/anti-oxidant balance and modulation of the release of some inflammatory endocoids, namely TNF-alpha and NO. The development of DSS-induced colitis was significantly attenuated by curcumin. Inhibition of p38 MAPK signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and the nitrite production in colonic mucosa, reducing the development of chronic experimental colitis. In addition, Curcumin seems promising with regards to remission in patients with quiescent Ulcerative Colitis. Preliminary evidence suggests that curcumin might be useful as an add-on therapy to control disease activity. One multicenter, randomized, double-blind, placebo-controlled study has examined the efficacy of curcumin enema (2 g/day) in the prevention of relapse in 82 patients with quiescent UC . Six-month treatment with curcumin significantly reduced measures of disease activity and severity and resulted in a lower relapse rate than with placebo in subjects on standard-of-care medication (sulfasalazine or mesalamine). In another randomized controlled trial in active UC patients treated with mesalamine, the percentage of patients in clinical remission was significantly higher after a one-month treatment with oral curcumin (3 g/day) than with placebo.
  How may Curcumin work against against diabetes?
Curcumin acts directly on liver cells to help prevent them from becoming fatty, and studies have concluded that Curcumin may have an anti-diabetic effect by decreasing serum fatty acid through the promotion of fatty acid oxidation and utilization. Curcumin also works directly on pancreatic beta cells to help them produce insulin normally. By helping the liver and the pancreas, Curcumin is taking stress off the two most important organs whose function declines before the onset of type 2 diabetes. Curcumin also influences key hormones, supports major body organs, and regulates inflammatory signaling all in ways that help correct or prevent metabolic problems. Curcumin helps lower inappropriately high levels of leptin (reducing leptin resistance) while boosting the all-important levels of the adiponectin (which lowers insulin resistance). Curcumin also helps activate the fat-burning gene signal PPAR gamma, which also helps to make more new, metabolically-fit fat cells. Curcumin directly reduces major inflammatory events from occurring inside white adipose tissue (tumor necrosis factor alpha, interleukin-6, and monocyte chemotactic protein-1). By lowering such inflammation, the source of overweight-induced disease is targeted. Oxidative stress and inflammation have been implicated in the pathogenesis of type 2 diabetes mellitus and related vascular complications. A large body of preclinical evidence suggests that the antioxidant, anti-inflammatory, and glucose-lowering activities of curcumin and its analogs may be useful in the prevention and/or treatment of type 2 diabetes. In a nine-month, randomized, double-blind, placebo-controlled study in 237 subjects with impaired glucose tolerance (pre-diabetes), no progression to overt diabetes was reported with a daily ingestion of a mixture of curcuminoids (0.5 g), while 16.4% of placebo-treated participants developed diabetes. In addition, curcumin supplementation was shown to reduce insulin resistance and improve measures of pancreatic β-cell function and glucose tolerance. Supplemental curcumin was found to be as effective as lipid-lowering drug atorvastatin (10 mg/day) in reducing circulating markers of oxidative stress (malondialdehyde) and inflammation (endothelin-1, TNFα, IL-6) and in improving endothelial function. Another randomized controlled trial also reported that oral curcumin supplementation (1.5 g/day) for six months improved endothelial function, insulin sensitivity, and metabolic markers associated with atherogenesis (plasma triglycerides, visceral fat, total body fat) in participants with type 2 diabetes. Finally, in a two-month randomized, double-blind, placebo-controlled study in 40 individuals with type 2 diabetic nephropathy (kidney disease), daily curcumin ingestion (66.3 mg) significantly reduced urinary concentrations of proteins and inflammation markers (TGF-β, IL-8), suggesting that curcumin might be helpful with slowing the progression of kidney damage and preventing kidney failure
  How may Curcumin work against obesity AND metabolic syndrome?
In the prevention and treatment of obesity and metabolic syndrome, Curcumin has been reported to modulate numerous targets that have been linked to obesity and insulin resistance. 1) Curcumin has been shown to downregulate the expression of TNF in various tissues. 2) Curcumin can suppress NF-κB activation induced by a wide variety of inflammatory agents through inhibition of degradation of IκBα. 3) Curcumin can inhibit the activation of IKK linked to the activation of NF-κB, and this leads to the suppression of expression of inflammatory biomarkers such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor. 4) Curcumin has been shown to downregulate the expression of various NF-κB-regulated proinflammatory adipocytokines including chemokines (such as MCP-1, MCP-4, and eotaxin) (199) and interleukins (IL-1, IL-6, and IL-8). Curcumin also suppressed the expression of plasminogen activator inhibitor type-1 through the inhibition of the transcription factor early growth response (Egr)-1 gene product that has been closely linked with insulin resistance and obesity. 5) Curcumin has been reported to mimic most antidiabetic drugs in that it activates PPAR-γ in hepatic stellate cells. 6) Curcumin has been shown to downregulate activation of c-Jun NH2 terminal kinase. 7) Curcumin has been shown to inhibit the Wnt/β-catenin pathway, which is closely linked to obesity. Later studies have indicated that Curcumin inhibits Wnt pathway signaling through downregulation of the transcription coactivator p300. Another potential mechanism by which Curcumin could inhibit β-catenin signaling is through inhibition of glycogen synthase kinase (GSK)-3β, which directly causes the phosphorylation of β-catenin. Curcumin was found to inhibit GSK-3β with as little as 66 nM IC50 (32). 8) Curcumin has been shown to induce the expression of hemeoxygenase (HO)-1 through the activation of Nrf2 in pancreatic cells and thus mediate the survival of these cells. 9) Curcumin downregulates the secretion of insulin-like growth factor-1 but induces the expression of insulin-like growth factor binding protein-3. 10) Curcumin interrupts leptin signaling by reducing phosphorylation levels of the leptin receptor (Ob-R) and its downstream targets. 11) Curcumin suppresses gene expression of Ob-R in HSCs. 12) Curcumin has been reported to increase the expression of adiponectin, which negatively controls obesity.
  How may Curcumin work against psoriasis?
Psoriasis is another pro-inflammatory disease. Considerable evidence, both in animals and humans, indicates that Curcumin may be effective against psoriasis.
  How may Curcumin work against depression and major depressive disorder?
Major depressive disorder (MDD) is a neuropsychiatric disorder associated with abnormal neurotransmission; it is primarily treated with drugs that improve the bioavailability of neurotransmitters like serotonin, noradrenaline, and dopamine in the brain. Characteristics of MDD also include alterations in the hypothalamus-pituitary-adrenal axis, increased neuroinflammation, defective neurogenesis, and neuronal death. A few clinical studies have examined the effect of curcumin alone or with conventional antidepressant drugs in MDD patients. A recent meta-analysis of six randomized controlled trials found that supplementation with curcumin significantly reduced depression symptoms. Significant improvements in the severity and frequency of specific depression-related symptoms occurred after four weeks of treatment, suggesting that a longer treatment period might be needed to uncover the antidepressant effects of curcumin. In a six-week, randomized, single-blinded, placebo-controlled study in 60 MDD patients, supplemental curcumin (~880 mg/day of curcuminoids) alone yielded a similar response rate to the antidepressant, fluoxetine (a serotonin reuptake inhibitor [Prozac]; 20 mg/day) in terms of depressive symptoms. Moreover, in a randomized controlled study in 100 participants taking escitalopram (a serotonin reuptake inhibitor [Lexapro]; 5 to 15 mg/week), supplemental curcumin (1,000 mg/day) for six weeks increased the antidepressant effect of the medication. Curcumin also induced a reduction in plasma concentrations of inflammatory markers and an increase in plasma concentrations of brain-derived neurotrophic factor compared to placebo (antidepressant drug alone).
  How may Curcumin work against Alzheimer's disease and cognitive decline?
A study in the Annals of Indian Academy of Neurology explored curcumin's potential for use in the treatment for Alzheimer's disease. Some of the key points included: Curcumin may help the macrophages, which play an important role in our immune system, clear the amyloid plaques found in Alzheimer's disease. Curcumin has anti-proliferative actions on microglia. Microglia are immune cells of the central nervous system that become active in response to any number of stressors on the body. However, if the microglia have been stimulated to react too often, they become hyper-reactive, which can trigger system-wide inflammation that can be difficult to stop. Curcumin has powerful antioxidant and anti-inflammatory properties. "Overall, curcumin decreases the main chemical for inflammation and the transcription of inflammatory cytokines … The exposure to curcumin also impaired the production of pro-inflammatory cytokines (IL-1, IL-6 and TNF-)." As chronic neuro-inflammation is considered one of the major factors in the development of Alzheimer's, it's possible too that curcumin may help in the treatment of other inflammatory disorders.Researchers found that Curcumin not only reduces oxidative damage and inflammation, but also reduces amyloid accumulation and synaptic marker loss and promotes amyloid phagocytosis and clearance. Curcumin worked to prevent synaptic marker and cognitive deficits caused by amyloid peptide infusion and abeta oligomer toxicity in vitro, and may help the immune system clear the brain of amyloid beta, which forms the plaques found in Alzheimer's disease. Clinical trials are in progress at UCLA with Curcumin for Alzheimer's. In the Alzheimer’s Disease Anti-Inflammatory Prevention Trial, researched showed that reducing inflammation has positive effects on patients with Alzheimer’s. Curcumin significantly lowered several inflammation markers, in addition to reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent. "Worldwide, there are over 1000 published animal and human studies, both in vivo and in vitro in which the effects of curcumin on various diseases have been examined. Studies include epidemiological, basic and clinical research on AD." - Acad Neurol. 2008 Jan-Mar; 11(1): 13–19. The effect of curcumin (turmeric) on Alzheimer's disease: An overview Neuroprotective activity has also been shown in curcumin. In Alzheimer’s disease (AD), a peptide called β-amyloid (Aβ peptide) aggregates into oligomers and fibrils and forms deposits known as amyloid (or senile) plaques outside neurons in the hippocampus and cerebral cortex of patients. Another feature of AD is the accumulation of intracellular neurofibrillary tangles formed by phosphorylated Tau protein. Abnormal microglial activation, oxidative stress, and neuronal death are also associated with the progression of the disease. Curcumin has been found to inhibit Aβ fibril formation and extension and to destabilize preformed fibrils in vitro (51-53). Metal chelation by curcumin might interfere with metal ion (Cu2+/Zn2+)-induced Aβ aggregation. Curcumin might also affect the trafficking of Aβ peptide precursor (APP) and the generation of Aβ peptides from APP. Abnormally activated microglia and hypertrophic astrocytes around amyloid plaques in AD brains release cytotoxic molecules, such as proinflammatory cytokines and ROS, which enhance Aβ formation and deposition and further damage neurons. Curcumin was found to reduce the inflammatory response triggered by Aβ peptide-induced microglial activation and increase neuronal cell survival. When injected into the carotid artery of a transgenic mouse model of AD, curcumin was found to cross the blood-brain barrier, bind to amyloid plaques, and block the formation of Aβ oligomers and fibrils. In other animal models of AD, dietary curcumin decreased biomarkers of inflammation and oxidative damage, increased Aβ peptide clearance by macrophages, dismantled amyloid plaques in the brain, stimulated neuronal cell growth in the hippocampus, and improved Aβ-induced memory deficits. As a result of promising findings in animal models. a few recent clinical trials have examined the effect of oral curcumin supplementation on cognition in healthy older adults and AD patients. A randomized, double-blind, placebo-controlled trial in 60 healthy older adults (mean age, 68.5 years) investigated whether acute (80 mg) or chronic (80 mg/day for 4 weeks) oral intake of curcumin could improve their ability to cope with the mental stress and change in mood usually associated with undergoing a battery of cognitive tests A significant reduction in mental fatigue and higher levels of calmness and contentedness following cognitive test sessions were observed in individuals who consumed curcumin (either acutely or chronically) compared to the placebo group. Additionally, the results of cognitive ability tests suggested that curcumin treatment had limited benefits on cognitive function, as shown by better scores in measures of sustained attention and working memory compared to placebo. The results of a six-month trial in 27 patients with AD found that oral supplementation with up to 4 g/day of curcumin - containing all three major curcuminoids - was safe.
  How may Curcumin work as an Anti-inflammatory?
Turmeric is safe and non-toxic and has been studied for anti-inflammatory properties, inhibiting various molecules that contribute to inflammation such as lipooxygenase, COX-2, leukotrienes, prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis factor (TNF), and interleukin-12 (IL-12).  One study compared the effectiveness of Curcumin – the active ingredient in turmeric – and a popular non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone. At the end of the six days, those taking the Curcumin and the NSAID enjoyed a significantly better anti-inflammatory response than placebo. The spice worked as well as the drug, but without the negative side effects. "Because of the crucial role of inflammation in most chronic diseases, the potential of Curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of Curcumin have been examined in animals and in humans." - Trends Pharmacol Sci. 2009 Feb;30(2):85-94. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Curcumin has also been shown to inhibit mediators of the inflammatory response, including cytokines, chemokines, adhesion molecules, growth factors, and enzymes like cyclooxygenase (COX), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). Nuclear factor-kappa B (NF-κB) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, and genes involved in cell proliferation, adhesion, survival, and differentiation. The anti-inflammatory effects of curcumin result from its ability to inhibit the NF-κB pathway, as well as other pro-inflammatory pathways like the mitogen-activated protein kinase (MAPK)- and the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT)-dependent signaling pathways. Inhibition of dextran sulfate sodium (DSS)-induced colitis by curcumin in mice has been associated with a downregulation of the expression of p38-MAPK and pro-inflammatory cytokine TNF-α and a reduction of myeloperoxidase (MPO) activity, a marker of neutrophil infiltration in intestinal mucosa. Curcumin has also been shown to improve colitis by preventing STAT3 activation and STAT3-dependent induction of cell proliferation in mouse colon. Moreover, curcumin was shown to attenuate the immune response triggered by collagen injections in a mouse model of rheumatoid arthritis, partly by blocking the proliferation of T lymphocytes in mouse splenocytes. In addition, curcumin has been found to reduce the secretion of TNF-α and IL-1β and the production of COX-2-induced prostaglandin G2. In one study, curcumin inhibited the secretion of matrix metalloproteins (MMPs) — responsible for the degradation of the synovial joints — in human fibroblast-like synoviocytes and in human articular chondrocytes. Curcumin has also been found to alleviate neuro-inflammation in a mouse model of traumatic brain injury, reducing macrophage and microglial activation and increasing neuronal survival. A placebo-controlled trial in 40 men who had surgery to repair an inguinal hernia or hydrocele found that oral curcumin supplementation (1.2 g/day) for five days was more effective than placebo in reducing post-surgical edema, tenderness and pain, and was comparable to phenylbutazone therapy (300 mg/day).
  What are the chemical properties of Curcumin?
Chemical Name Diferuloylmethane
Definition A β-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups
Systemic Name (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)
Molecular Formula C21H20O
Molar mass 368.38 g/mol
Appearance Bright yellow-orange powder
Melting Point 183 °C, 361 °F
PubChem 969516
Biofunction Enzyme cofactor
Chemical Taxonomy Organic Chemicals / Hydrocarbons / Aromatic Compounds /  Phenols / Catechols / Curcuminoids
Chemical Structure
Organic Source Taxonomy Kingdom
Plantae (Plants) 
Tracheobionta (Vascular plants)
Spermatophyta  (Seed plants) 
Magnoliophyta  (Flowering plants)
Liliopsida  (Monocotyledons) 
Zingiberaceae  (Ginger family) 
Curcuma (Curcuma)
Curcuma longa  (Turmeric)

  Why Turmeric root extract Curcumin may provide health benefits?

Certain plants manufacture chemicals that repel predators, parasites and diseases. Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense. Over time, plants with higher levels of organic compounds that deter attackers become more successful, because of their advanced protection. In nature's never-ending interaction between predator and prey, insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies. Monitoring this evolution between plants and insects represents an important field of ecological research. Scientists have discovered that many phytochemicals manufactured in plants and roots not only prevent insect attack or fight plant infections, but also provide human health benefits. Many cultures create their own botanical pharmacies as the lore of medicinal plants and remedies is handed down through generations of healers. With the advent of sophisticated laboratory testing, biologists are finding that the many indigenous plants and roots from around the world provide medicinal value, and their metabolites are candidates for research. Curcumin’s structure is similar to other natural polyphenolics (chemicals containing multiple "phenol" groups) produced by plants in response to infectious attack. These natural polyphenols often have potent anti-oxidant and anti-inflammatory properties as well as immune support health benefits. Curcumin from Turmeric, resveratrol from grapes, pterostilbene from blueberries, and catechins from green tea all contain polyphenolic antioxidants and have been studied for medicinal or preventive value. Curcumin has been studied for anti-oxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities, mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered TNF blockers (humira, remicade and enbrel), vascular endothelial cell growth factor blocker (avastin), human epidermal growth factor receptor blockers (erbitux, erlotinib, and geftinib), and HER2 blocker (herceptin). Considering the recent scientific bandwagon that multi-targeted therapy is better than mono-targeted therapy for most diseases, Curcumin is a phytonutrient that can be considered an ideal "Spice for Life". More than 5000 papers published within the past two decades have revealed that Curcumin has extraordinary potential in promoting health through modulation of numerous molecular targets.


  What is the history of Curcumin and Turmeric?

Turmeric is an ancient spice and a traditional remedy. It has been used in food and as medicine for at least 4,000 years, first in India (Ayuverdic) and other parts of Asia, and later in Africa and the Caribbean. Researchers in India recently identified mineral remnants of turmeric and ginger on the cooking pots of ancient Indus River remains, one of the first urban civilizations.These ancient civilizations have vast trial and error experience with many different herbal remedies and food preparations and they selected Curcumin as a food additive and major tool for medicinal use based on efficacy. Numerous therapeutic activities have been assigned to Turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastro-intestinal systems, aches, pains, wounds  and disorders. Marco Polo, writing of his travels in China, described Turmeric in the 13th century: "There is also a vegetable which has all the properties of the true saffron, as well as the color, and yet it is not really saffron. Turmeric is held in great estimation, and being an ingredient in all their dishes, it bears, on that account, a high price."  The high degree of reverence for Turmeric is established by the fact that it is used in many cultures, each having its own name for the spice: Burmese: fa nwin. Chinese: wong geung fun, yüchiu. Danish: gurkemeje. Dutch: geelwortel. Finnish: keltajuuri. French: curcuma, saffron des Indes. German: gelbwurz, kurkuma. Icelandic: turmerik. Italian: curcuma tumeric Indian: haldee, haridra, haldi, huldee, huldie. Indonesian: kunjit, kunyit. Japanese: ukon circumin Malay: kunjit. Norwegian: gurkemeie, Polish: klacze kurkumy. Portuguese: açafrão-da-Índia. Russian: zholtymbir. Spanish: azafrán de la India, azafran arabe. Sinhalese: kaha. Swedish: gurkmeja. Tamil: munjal. Thai: ka min. Vietnamese: botnghe
  Why hasn't the pharmaceutical industry patented Curcumin?
Pharmaceutical corporations tried registering patents for Curcumin and Turmeric because of the much heralded scientific evidence and the long history of its healing properties. However, that same evidence and history of Curcumin being used medicinally for centuries was the reason the United States Patent and Trademark Office rejected and revoked the rights for Turmeric patent 5401504 on the grounds that the claims were not new: "USPTO unequivocally rejected all six claims made on August 13, 2001 ruling that Turmeric's medicinal properties were not patentable."  University of Texas MD Anderson Cancer Center states "in the case of Curcumin, a natural compound, no company can reap the benefits if Turmeric shows itself to be an effective anti-cancer drug." This loss to Big Pharma is a gain for educated consumers.
  news and published studies on Curcumin and Turmeric

May  2016

Turmeric can improve memory and attention in old age, study finds
Science Alert, May 2016
"Curcumin has multiple physiological effects," said researcher Andrew Scholey, from Swinburne University of Technology. "It’s known to reduce inflammation and improve blood flow. It influences multiple processes that nudge brain function in a positive direction." In their initial research, Scholey and his team recruited 60 volunteers aged between 60 and 85, and split them into two groups. One group was given capsules with curcumin, and the other a placebo. The participants then completed a number of computerised mental tasks – such as word and picture recall, simple subtraction, and reaction time tasks - a few hours after taking the supplement, and then after taking it daily for four weeks. Overall, the participants who’d taken the curcumin capsules performed better at the computerised measures of working memory and vigilance. They also reported feeling reduced fatigue as well as improved calmness, contentedness, and stress during testing at the end of the four-week trial. "To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioural effects in humans," the researchers reported in the Journal of Psychopharmacology last year. They also found that there were benefits outside of cognitive improvements. "A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL (low-density lipoprotein) cholesterol and had no effect on haematological safety measures," they reported.

The Spice in Curry Can Improve Memory and Energy Levels
The Science Explorer, May 2016
Past studies have found that older people living in cultures where curry is a staple have better cognitive function and a lower prevalence of dementia, and curcumin was identified as a likely reason for this. A German study found that curcumin can act as part of the brain’s repair kit by stimulating the growth of nerve cells. Another study published in the National Center for Biotechnology found that curcumin can actually encourage the birth of new brain cells, particularly in the hippocampus, a brain region that regulates learning, memory, and mood. In a new study, the Australian researchers recruited 60 volunteers aged between 60 and 85 in order to explore how curcumin has its effects on cognition. The volunteers were split into two groups — one was given capsules with a curcumin formulation, and the other was given a placebo. A few hours after taking the curcumin pill or the placebo, the participants were asked to complete various computerized mental tasks — word and picture recall, simple subtraction, and reaction time tasks. Following this initial experiment, the volunteers took the curcumin supplement daily for four weeks. "To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioural effects in humans," the researchers report in the Journal of Psychopharmacology. At the end of the four-week trial, the participants who had taken the curcumin capsules performed better overall at the memory and vigilance tasks. Plus, they reported feeling a boost of energy levels as well as lower stress and improved calmness and contentedness. "Curcumin has multiple physiological effects," lead researcher Andrew Scholey, director of the University’s Centre for Human Psychopharmacology, said in a press release. "It’s known to reduce inflammation and improve blood flow. It influences multiple processes that nudge brain function in a positive direction."

The Health Benefits Of Turmeric: Better Than Ibuprofen?
Inquisitr.com May 2016
"Turmeric and curcumin, the most active constituent of the spice, have been the subject of thousands of studies. This research shows that curcumin has potent antioxidant and anti-inflammatory properties as well as antiviral, antibacterial, antifungal and immune modulating activities.By helping support the body’s inflammation levels, it is a valuable supplement for those active in sports. The repetitive trauma caused by athletic training causes inflammation and pain that can be controlled with curcumin (turmeric).” Turmeric grows naturally, of course, but is not well absorbed unless taken in supplement form, according to some herbalists. This could come by the way of teas, the roots being incorporated into smoothies, or true curcumin supplementation, which carries enough anti-inflammatory properties to be beneficial. As with many herbs, it is known that the benefits of turmeric are multi-faceted; it also has been shown to decrease the risk of cardiovascular disease and certain types of cancers. According to Shape, Maribeth Evezich, M.S., R.D., a dietitian based in New York City, says that the powerful anti-oxidant does have anti-inflammatory powers.

Curcumin controls MTB infection in model
Healio.com May 2016
Researchers in this study showed an ability to control Mycobacterium tuberculosis in a macrophage infection model using curcumin, according to recent research. “In summary, we have shown that curcumin can augment the ability of human macrophages to control Mycobacterium tuberculosis (MTB) infection,” Xiyuan Bai, PhD, from the Department of Medicine at the Denver Veterans Affairs Medical Center in Denver, Colorado, and colleagues wrote in their study.

Using turmeric for inflammation
Reflector.com May 2016
Curcumin is the major component of turmeric that provides an anti-inflammatory effect. It’s an interesting herbal because it also has antibacterial, antiviral, antifungal, antidiabetic, antifertility and antitumor properties. In an animal study, curcumin was found to give the same anti-inflammatory response as cortisone for acute inflammation. Taking curcumin may be beneficial for those with osteoarthritis, RA, fibromyalgia and ulcerative colitis.

Reasons Why Turmeric Is the Spice Nutritionists Swear By
DivineCarlone.com May 2016
A study shows that curcumin helps your liver metabolize cholesterol at a faster rate and also helps prevent it from accumulating on your arterial walls. A 2013 human trial concluded that curcumin's effectiveness in battling depression is, in fact, similar to that of prescription anti-depressants. By increasing the release of dopamine and serotonin—otherwise known as "feel good" neurotransmitters—concentrated doses of curcumin can help battle depression naturally.

Amber Wonder: The power of turmeric
On Manorama, May 2016
Studies around the world have found that curcumin has anti-arthritic, anti-cancer, anti-viral and anti-infl ammatory properties. “It is listed in superfoods because it is proven to be the healthiest food and has been a part of Asian medicine for centuries,” she says. “It acts on the biochemical processes in the body. Apart from having anti-cancer and anti-arthritic properties, curcumin is also said to promote fat loss and prevent cellular damage caused by the pesticides in food. “Curcumin is a powerhouse of antioxidants, hence it is labelled as a superfood. Consuming it reduces the risk of disease and prolongs life. It is also used in the treatment of Alzheimer’s disease and to improve brain function. It is used as an anti-depressant, too,” she says.

Chemical in turmeric 'stimulates the immune system to fight drug-resistant strain'
Mail Online, April 2016
By stimulating white blood cells - a key part of the immune system - curcumin was able to successfully remove Mycobacterium tuberculosis from infected cells. ‘Our study has provided basic evidence that curcumin protects against Mycobacterium tuberculosis infection in human cells. ‘The protective role of curcumin to fight drug-resistant tuberculosis still needs confirmation, but if validated, curcumin may become a novel treatment to modulate the host immune response to overcome drug-resistant tuberculosis.’

The Health Benefits of Turmeric
Shape, April 2016
Turmeric and curcumin, the most active constituent of the spice, have been the subject of thousands of studies," says Maribeth Evezich, M.S., R.D., a dietitian based in New York City. "This research shows that curcumin has potent antioxidant and anti-inflammatory properties as well as antiviral, antibacterial, antifungal and immune modulating activities." You could benefit from up to a teaspoon a day. Curcumin may also have artery-clearing effects. In one study from Taiwan, people who consumed curcumin extracts daily significantly reduced their levels of bad cholesterol (LDL) in just 12 weeks.

Why turmeric is being touted as ‘nature’s wonder drug’
JWeekly.com April 2016
The principal element in turmeric’s healing power is curcumin, a chemical compound that is gaining popularity (especially in dietary supplements and cosmetics) for its reported antioxidant and antiseptic qualities. People feel that it is an invaluable tool for staving off the signs and symptoms of aging. Curcumin also has great anti-inflammation properties and has been found to be highly effective in helping people manage pain and swelling. It’s used by those suffering from arthritis and joint pain, with some saying it’s even more powerful and effective than over-the-counter pain medications. Root and powder forms of turmeric, a relative of ginger Root and powder forms of turmeric, a relative of ginger Curcumin also has been found to protect the brain against diseases such as Alzheimer’s and Parkinson’s, and assist the body in managing heart disease. Even more, preliminary studies have found that curcumin can inhibit cancer and tumor cell growth.

Turmeric: The wonder spice?
Xpose.ie April 2016
Scientists found that by stimulating human immune cells called macrophages, curcumin was able to successfully remove mycobacterium tuberculosis, the bacteria that causes tuberculosis, from experimentally infected cells in culture. In Asia, turmeric, which comes from the root of the Curcuma longa plant, is used as anti-inflammatory agent to treat a wide variety of conditions, including flatulence, jaundice, menstrual difficulties, toothache, bruises, chest pain and colic.

Curcumin can kill the bacteria that cause drug-resistant TB
The Sun, April 2016
Turmeric is popular in Asia for treating a variety of health conditions – as well as having anti-inflammatory and antioxidant effects. Curcumin is a potent inducer of a mechanism used by human immune cells to kill bacteria. In the current study, researchers tried to determine the effects of curcumin on Mycobacterium TB and found that by stimulating white blood cells - a key part of the immune system - curcumin was able to successfully remove Mycobacterium tuberculosis from infected cells.

Curcumin protects against myocardial infarction-induced cardiac fibrosis
Drug Design, Development and Therapy, April 2016
Curcumin attenuated cardiac fibrosis following MI by regulating collagen deposition, ECM degradation, and CFs’ proliferation and migration. The protective effects of curcumin were attributed to SIRT1 activation. The present study provides new insights into the mechanism of the anti-fibrotic effects of curcumin in the heart. Therefore, curcumin could be tested as an auxiliary therapeutic agent, along with classic treatments, to improve the prognosis in patients with myocardial fibrosis after MI.

Curcumin May Defeat Drug-Resistant Tuberculosis
Medical Daily, April 2016
Curcumin is a substance found in turmeric, a root that’s in the ginger family and originally found in India. Curcumin is turmeric’s most active ingredient and offers anti-inflammatory and antioxidant properties. For centuries, turmeric has been used in both food and traditional medicine; it’s typically boiled down, baked, and ground into a yellow powder. Curcumin gives turmeric its yellow coloring, and as a separate entity from turmeric is often used as an herbal supplement, or added to cosmetics, spices, or food coloring. For thousands of years, turmeric has been used to treat arthritis, stomach problems, and other health issues in traditional medicine and spiritual rituals — more as an herbal supplement than anything else, of course. In 2014, curcumin was shown to reduce post-traumatic stress disorder (PTSD) symptoms, and another study found that curcumin also held potential to shrink cancer tumors or slow their growth. All in all, curcumin has been studied robustly over the years, but most of its health benefits have been played out in laboratory dishes and have yet to be transferred to animal or human trials.

The Health Benefits Of Curry Powder
Huffington Post, April 2016
The journal "Food and Chemical Toxicology" published a study that found that turmeric's active compound, curcumin prevented spikes in blood sugar and improved insulin sensitivity. They concluded that the benefits of turmeric might be due in part to anti-inflammatory effects.

Turmeric Spice Could Fight Drug-Resistant Strains of Tuberculosis
Headlines and Global News, April 2016
The researchers tested out the effects of curcumin in the laboratory setting and found that after stimulating macrophages, which are cells from the body's immune system, the substance was able to remove Mycobacterium tuberculosis, the bacterium that causes TB, through a process that involved preventing the activation of nuclear factor-kappa B. This process removed the bacterium from the cells that were infected during the experiment.

An addition to efficacy of turmeric, helps fight drug-resistant TB
Zee News, April 2016
The study has further revealed that curcumin, which is a substance in Turmeric can successfully remove Mycobacterium tuberculosis, which happens to be the causative bacterium of tuberculosis.

Turmeric may help overcome drug-resistant TB
The Times of India, April 2016
Curcumin--a substance in turmeric--may help fight drug-resistant tuberculosis. Turmeric is commonly used in Indian food and is considered to have anti-inflammatory, antioxidant, and even anticancer properties.

Turmeric May Help Fight Tuberculosis
NewsMax Health, April 2016
The ability of curcumin to modulate the immune response to Mycobacterium tuberculosis points to a potential new tuberculosis treatment that would be less prone to the development of drug resistance. Read more: Common Spice May Aid in Fight Against TB

Turmeric can help combat tuberculosis
LiveMint.com April 2016
According to a US study, turmeric contains a substance called curcumin which can help fight tuberculosis. Researchers from University of Nebraska believe curcumin, which is also responsible for the yellow orange colour of turmeric, by stimulating immune cells called macrophages, can successfully kill the bacteria (mycobacterium tuberculosis) which causes tuberculosis. Turmeric is known for its anti-inflammatory, antioxidant, and anti-cancer properties and is used for its medicinal properties in several Asian countries. The study was published in the journal Respirology here.

Turmeric Extract May Be Your Best Bet For Healing Knee Osteoarthritis
Collective Evolution, April 2016
Curcuminoid extract of turmeric reduced inflammation in patients suffering from knee osteoarthritis.

Tumeric Benefits: Turmeric Can Do Wonders In Your Heart and Body
Parent Herald, April 2016
The main ingredient of turmeric is the curcumin and its yellow color gives its curry spice. Turmeric can help in maintaining the heart health. It actually reduces the plaque build-up that can lead to the blood clot that causes stroke or heart attack. It also lessens the cholesterol oxidation by reducing the LDL or bad cholesterol by 56 percent and the serum triglyceride levels by 27 percent. In addition, tumeric also lowers the total cholesterol by 33.8 percent. Turmeric also has an anti-inflammatory and antioxidant properties. It suppresses the COX enzyme which eases the production of pro-inflammatory signals in the body. The antioxidants protect your body from free radicals.

Acupuncture Plus Curcumin Protects The Liver
Healthcare Medicine Institute, April 2016
Acupuncture combined with oral curcumin intake protects the liver from fibrosis. Curcumin is the chief curcuminoid in turmeric (Jiang Huang, Rhizoma Curcumae Longae). Curcumin is bright yellow, hence the name ginger yellow in Chinese. Jiang is translated as ginger and huang means yellow. Curcumin is a principle polyphenol in Jiang Huang, a member of the ginger family of herbs used for enhancing blood circulation in Traditional Chinese medicine (TCM). The researchers concluded that acupuncture plus curcumin “potently protected the liver” from injury and fibrogenesis. liver fibrosis.

Turmeric holds cancer related benefits
The News Tribe, April 2016
Curcumin, a bioactive ingredient found in turmeric (Curcuma longa) can prevent and cure bowel cancer (colorectal cancer). So far, anti-cancer properties of curcumin were well-known but the mechanism by which the bright yellow organic compound cures the cancer remained a mystery. The team, headed by R Baskaran, associate professor (biochemistry and molecular biology) at Pondicherry University, discovered the mechanism by which curcumin kills hereditary non-polyposis colorectal cancer cells and documented their findings. `Molecular and cellular biochemistry’, a and cellular biochemistry’, a peer-reviewed international journal brought out by Springer Science+Business Media, New York, published their research paper in its March, 2016 edition. The team included Hemanth Naick, a PhD student of Pondicherry University, and Shunqian Jin, a researcher at University of Pittsburgh cancer institute.

Curcumin in turmeric kills colon cancer cells
Times of India, March 2016
Studies on the effect of curcumin on cancer and normal cells will be useful for the ongoing preclinical and clinical investigations on this potential cancer chemo-preventive agent.

Researchers in Pondicherry University shed light on how curcumin kills tumors
The Hindu, March 2016
Curcumin, derived from the dietary turmeric (Curcuma longa) is an effective anti-cancer, anti-inflammatory, and antioxidant agent. Studies on the effect of curcumin on the entire cell death process, both in tumour and normal cells, are useful for the ongoing preclinical and clinical investigations on this potential chemo-preventive agent. While curcumin’s chemoprevention property is well documented, its ability to kill colorectal cancer cells is not as clearly known or understood. Although curcumin-induced cytotoxicity is due to superoxide anion production, the precise mechanism leading to cell death activation remains unknown. Towards this end, the research group previously reported in a series of publications that human non-polyposis colorectal cancer cells (HNPCC) arising due to genetic mutations in mismatch repair genes (MMR) are highly sensitive to curcumin due to unrepaired DNA damage. In a recent report, published in the international peer-reviewed journal “Molecular and Cellular Biochemistry” (Feb 2016), the authors now document that the protein levels of gadd45a (genes activated during DNA damage), are increased following curcumin treatment. The study demonstrated how the trigger of genes is required for cell death induced by curcumin in colorectal cancer cells and that the mismatch repair (MMR) status strongly influences curcumin sensitivity.

Curcumin prevents weight gain
eMaxHealth.com March 2016
Mohsen Meydani, DVM, PhD, director of the Vascular Biology Laboratory at the USDA HNRCA explained curcumin stopped new blood vessels from growing that make fat spread. The mice also had lower cholesterol and less liver fat.

Health Benefits of Turmeric
Science Mic, March 2016
Curcumin gives turmeric star qualities of being both anti-inflammatory and an antioxidant, which means its consumers will reap external and internal benefits, according to the Washington Post. "It is a known fact that curcumin is a strong antioxidant compound with great ability to scavenge the oxygen-derived free radicals," a 2013 study published in Current Neuropharmacology said. "Consequently, curcumin could be a potential neuroprotective agent." For joint and pain relief, these curcumin capsules were comparable to taking ibuprofen, a 2009 study found. Turmeric has been linked to treating a long list of diseases, such as Alzheimer's and Parkinson's due to its ability repairing brain cells and improving memory in lab rats, the 2013 study said. Another study found curcumin pills to assist in delaying Type 2 diabetes compared to taking a placebo.

The curry cure: Golden spice that could help fight cancer
Express, March 2016
“Curcumin can target a variety of processes which are important in breast cancer development,” he says. “These include reduced proliferation, reduction in potential to spread and increase in programmed cell death of tumour cells.” Recent studies have found that curcumin appears to prevent the formation of molecules that allow circulating tumour cells to spread and attach to other body parts. It is possible that curcumin could interfere with one of the important mechanisms of cancer development. However the benefits of curcumin as an anti-cancer agent may not be restricted to breast well-being. Some studies in humans and from laboratory experiments suggest potential benefit in pancreatic cancer, colorectal cancer and lung cancer.

Curcumin Helps Patients Tolerate Chemo
Newsmax.com March 2016
Studies have shown that curcumin not only enhances the effectiveness of radiation treatment against the cancer, but also protects surrounding normal cells within the treatment area.

Drug-Free Alternatives to Treating Back Pain
Newsmax.com March 2016
Curcumin from turmeric. While turmeric has received much attention in the alternative healthcare field, it’s actually curcumin that has the active compounds that are most effective. It acts on multiple inflammation pathways and neutralizes free radicals — the root causes of pain. Curcumin has been clinically studied on its own and in combination with boswellia for treating people with rheumatoid and osteoarthritis, as well as, or better than, prescription drugs. Scientific studies of human spinal discs treated with curcumin showed an 80 percent reduction in inflammatory compounds and a 70 percent reduction in cartilage-damaging enzyme activity.

Curcumin may prevent liver damage from acetaminophen / paracetemol
J Pharm Pharmacol. March 2016
Curcumin prevented acetaminophen-induced liver damage. Curcumin lessened acetaminophen-induced liver histological damage and increment in plasma alanine aminotransferase and aspartate aminotransferase activity. Additionally, curcumin reduced the decrease in oxygen consumption measured using either succinate or malate/glutamate as substrates (evaluated by state 3, respiratory control ratio, uncoupled respiration, and adenosine diphosphate/oxygen ratio), in membrane potential; in ATP synthesis; in aconitase activity; and in the activity of respiratory complexes I, III, and IV. These results indicate that the protective effect of curcumin in acetaminophen-induced hepatotoxicity is associated with attenuation of mitochondrial dysfunction.

Effect of turmeric on colon histology
BMC Complementary and Alternative Medicine, March 2016
 improved body weight gain, mean macroscopic and microscopic ulcer scores in the colon of rats suffering from acetic acid-induced IBD. CL reduced both MPO and IL-23 in the mucosa of the colon. The increase in the mean serum glutathione level may help in the reduction of oxidative stress associated with IBD.

Expert backs three spices in diet to keep cancer away
Times of India, February 2016
Curcumin proved to be more effective at reducing inflammation than over-the-counter aspirin and ibuprofen, and as effective as the more powerful drug Celebrex. It also proved as effective in thwarting breast cancer cells as tamoxifen, a drug widely used to stop its spread or recurrence.

7 ways turmeric can change your life
Daily O, February 2016
The general consensus is that curcumin, a component of turmeric is the protective agent here. It improves memory, focus and cognition too by increasing the growth of new neurons and fighting various degenerative processes in the brain.

Your Health: Why is everyone raving about turmeric?
NZ Herald, February 2016
Modern scientific research is now confirming what traditional medicine has known - turmeric (and curcumin, the active constituent) has beneficial actions on many bodily systems. Recent studies have revealed turmeric has a wide range of pharmacological and clinical properties, including as an antioxidant, digestive, anti-inflammatory, antiplatelet (decreases clotting), cholesterol lowering and anti-carcinogenic.

What Will Curcumin Do For Me? Stuart’s Dr. True Has The Answer
Stuart Magazine, February 2016
Curcumin is the active component of the spice called turmeric. It has been in use as a spice and traditional medicine for more than 2,500 years. Turmeric is found throughout the world and has a unique name in more than 60 languages. The curcumin extract of turmeric is not new; it was first isolated in 1842. Recent scientific discoveries have confirmed that curcumin may have amazing anti-inflammatory and disease-inhibiting properties. It has the potential to inhibit the growth of many types of cancer, reverse insulin resistance in Type 2 diabetes, inhibit plaque formation in atherosclerosis and address factors that stop the development of Alzheimer's disease. These are just a few of the diseases and maladies that have been researched in the last decade in which curcumin was found to have a positive impact.

Curcumin boosts effect of training on muscles
Ergo-Log.com February 2016
Athletes looking to extend their endurance capacity may achieve better results by taking high doses of curcumin. And curcumin supplementation may also help people who are trying to lose weight by doing intensive cardio training.

Turmeric offers a wide range of health benefits
ConsumerAffairs.com January 2016
As one of the most thoroughly researched plants ever, there are currently 8,421 peer-reviewed articles published which claim to prove the numerous benefits of turmeric. Benefits Packed with anti-inflammatories and antioxidants, turmeric has been shown to fight free radicals, rejuvenate the cells, cleanse the liver, protect the heart, boost mood, and support the brain. It may also be helpful in treating osteoarthritis, viral and bacterial infections, stomach ulcers, cancer, and other conditions. “It’s a very powerful plant,” says Natalie Kling, a Los Angeles-based nutritionist who recommends it to clients for joint pain. Kling says that when taken as a supplement, it helps quickly.

Curcumin Shows Promise as Depression Treatment
Psychiatric Advisor, January 2016
“Curcumin does have an effect on several physiological systems that are implicated in the causes of depression,” Roger S. McIntyre, MD, a professor of psychiatry and pharmacology and head of the Mood Disorders Psychopharmacology Unit at the University of Toronto, told Psychiatry Advisor. “It certainly would be a reasonable hypothesis that it could be in possession of antidepressant properties.” One recent study finding support for the antidepressant effects of curcumin was published in October 2014 in the Journal of Affective Disorders.2 In the randomized, double-blind, placebo-controlled trial, researchers from several universities in Australia assigned 56 patients with MDD to receive either curcumin or placebo capsules twice a day for 8 weeks. Until the fourth week, each group had similar improvements in scores on the Inventory of Depressive Symptomatology self-rated version (IDS-SR30). From the fourth week through the eighth week, however, there was a significantly greater improvement in scores in the curcumin group, especially among patients with atypical depression. “Curcumin can influence several mechanisms in the body; in particular, it is a powerful natural anti-inflammatory and antioxidant,” study co-author Adrian Lopresti, PhD, a clinical psychologist and researcher at the School of Psychology and Exercise Science at Murdoch University, told Psychiatry Advisor. “This has relevance to depression because people with depression have greater inflammation and oxidative stress, which can affect all major organs in the body, including the brain.” Chronic inflammation can decrease levels of serotonin and dopamine and lead to degeneration in certain brain areas. It is possible that the antioxidant and anti-inflammatory effects of curcumin can restore these neurotransmitters and protect the brain, eventually leading to improvements in mood.

Fight depression with turmeric
TheHealthSite.com January 2016
A dose of curcumin increases serotonin as well as dopamine levels in the brain. An imbalance in serotonin levels influences the mood, which can eventually lead to depression, while dopamine is a neurotransmitter that helps control the brain’s reward and pleasure centers.

Prevent Cancer, Heart Disease
NewsMax.com December 2015
Many studies have shown that curcumin, the active ingredient in turmeric, protects against many diseases including cancer and Alzheimer's. A study at the University of California, Los Angeles, found curcumin slows the buildup of amyloid plaques — one of the hallmarks of Alzheimer's — in the brain, and a laboratory study at the University of Illinois revealed that curcumin protected cells from damage caused by beta-amyloid. Latest News Update Get Newsmax TV At Home » Special: Researchers at Johns Hopkins University Medical School showed that curcumin protected against the nerve cell damage associated with Parkinson’s disease, and numerous studies have shown curcumin fights many types of cancer including colon, pancreatic, and breast. Read more: Prevent Cancer, Heart Disease With Ethnic Cuisine

Help for depression and anxiety
EveryDayHealth.com December 2015
Curcumin helps mitigate depression and anxiety. The abstract from a 2014 study in the Journal of Affective Disorders reads: Curcumin, the principal curcuminoid derived from the spice turmeric, influences several biological mechanisms associated with major depression, namely those associated with monoaminergic activity, immune-inflammatory and oxidative and nitrosative stress pathways, hypothalamus-pituitary-adrenal (HPA) axis activity and neuroprogression. We hypothesised that curcumin would be effective for the treatment of depressive symptoms in individuals with major depressive disorder.

Arthritis help may come from a surprising source
Clinton Herald, December 2015
Curcumin, the active chemical in the spice turmeric, has several potential uses. I wrote some months ago about its possible use in inflammatory bowel disease, but I was able to find several studies showing benefit in people with both osteoarthritis and rheumatoid arthritis. The usual dose was 500 mg (of curcumin) two or three times daily. There were few side effects in the studies, but there is the potential to worsen bleeding in people taking anticoagulants, such as warfarin. Curcumin seems a reasonable alternative to anti-inflammatories in people with arthritis, and it might be worth a trial, especially in people who experience side effects on the standard drugs. As always, finding a high-quality product is essential, since supplements are largely unregulated.

Turmeric for Alzheimer's Disease
About.com Health, December 2015
Turmeric contains a class of compounds called curcuminoids, which include a substance known as curcumin. Known to possess antioxidant properties, curcumin may play a key role in turmeric's potential effects against Alzheimer's disease. Preliminary research indicates that the curcumin found in turmeric may help curb inflammation and combat oxidative stress, two factors found to contribute to the development of Alzheimer's disease. What's more, some preliminary studies suggest that curcumin may help thwart the Alzheimer's-associated breakdown of nerve cells in the brain. There's also some evidence that turmeric may inhibit the formation of Alzheimer's-related brain plaques. Known to accumulate between nerve cells, these plaques form when protein fragments called beta-amyloid clump together. Beta-amyloid also appears to impair brain function by destroying synapses (structures through which nerve cells transmit signals to one another). In several animal-based studies, scientists have observed that turmeric may help clear beta-amyloid from the brain. For example, a mouse-based study published in Current Alzheimer Research in 2012 found that treatment with turmeric extract significantly reduced brain levels of beta-amyloid in mice genetically engineered to develop symptoms of Alzheimer's.

The link between cancer and diet
The News Tribe, December 2015
Curcumin, anti-ageing factor in this wonder spice. Renders anti-inflammatory and antioxidation benefits, hence used traditionally for a healthy glowing skin. Besides, it also destroys pro-carcinogens, thus protecting against cancer. It is also seen as that inclusion of turmeric in the diet reduces the incidences of senile diseases like Alzheimers.

Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS).
Eur J Appl Physiol, December 2015
Oral curcumin likely reduces pain associated with DOMS with some evidence for enhanced recovery of muscle performance. Further study is required on mechanisms and translational effects on sport or vocational performance.

Liver Health
LiveSupport.com November 2015
Turmeric’s primary chemical compound is curcumin, a yellow substance with a long history of aiding liver health. Numerous studies have linked curcumin to reductions in liver cancer and liver fibrosis. According to a study in a 2012 edition of the Journal of the Medical Association of Thailand, scientists found that the livers of diabetic rats were repaired and even regenerated with the help of turmeric. According to a 2009 study in the journal Liver International, curcumin showed an ability to inhibit several factors (like nuclear factor-kappaB) that helped reduce liver inflammation. In addition, the authors found that curcumin helped protect against liver injury from known liver cell toxins.

LiveScience.com November 2015
Curcumin is found primarily in turmeric, a member of the ginger family. It gives turmeric its distinctive yellow color. Because of its curcumin, turmeric has been used as a medicinal remedy in India for centuries, said Premkumar. “The claimed effects of curcumin range from relieving flatulence to curing Alzheimer’s disease and cancer,” said Premkumar. Animal studies have shown good results when looking at oral administration of curcumin and to inhibit the spread of mouth, stomach, liver and colon cancer. Studies are under way to investigate this effect in humans. Curcumin is an effective anti-inflammatory agent and antioxidant. It may also affect carcinogen metabolism, helping the body get rid of toxic compounds, and aid in combating cancer cell growth and tumors, according to the Linus Pauling Institute. All of these factors contribute to its being a potentially effective cancer-prevention agent. Based on successful animal trials, it has been suggested that curcumin could aid in inflammatory diseases like rheumatoid arthritis as well as cystic fibrosis and Alzheimer’s disease, but studies are either not yet under way or are inconclusive, according to the Linus Pauling Institute. According to Premkumar, curcumin can also be helpful in cardiovascular protection by lowering LDL cholesterol levels and increasing HDL (good) cholesterol levels. “Treatment with curcumin selectively increases the expression of low-density lipoprotein (LDL) receptor levels and is able to clear LDL, which is bad or lousy cholesterol,” he said.

Possible BPH Therapy Seen in Using Curcumin as Dietary Supplement
BPH News, November 2015
Recent research revealed curcumin significantly decreases prostate weight and volume in animal models of benign prostatic hyperplasia (BPH). The study entitled “Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model” was published in the journal BMC Complementary and Alternative Medicine. Benign prostatic hyperplasia (BPH) is a common condition affecting elderly men and is characterized by a hyperplastic growth of the prostate gland, causing pressure on the bladder and urethra. Curcumin, one of the primary ingredients in turmeric and curry powders, and with beneficial effects in several diseases including retinal diseases and Parkinson’s disease, was also suggested to enhance degradation of a key receptor in prostate cancer and induce cancer cell death. The team observed that curcumin inhibited the development of BPH, significantly lowering prostate weight and volume. Additionally, authors observed curcumin decreased expression of VEGF, TGF-ß1, and IGF1 when compared to the control group (important growth factors in prostate tissue). These findings suggest that curcumin could potentially be used as an herbal treatment or functional food for BPH management, this way bypassing the adverse side effects observed in commonly used treatments for the condition.

Maintain liver health with curcumin
ChiroEco.com November 2015
Curcumin is the main component of the spice turmeric, giving it a distinctive bright golden coloring. Turmeric is a member of the ginger family and often used as a staple in Indian cooking, particularly as a primary ingredient in curry. Curcumin is thought to prevent the accumulation of fatty acids in the liver, thereby staving off the possibility of NAFLD before it progresses to NASH as well as other liver diseases. Furthermore, curcumin is a powerful antioxidant, so it may also protect against the effects of age on the liver, as well as inhibit the formation of enzymes that can cause cellular death. A 2015 review discussed curcumin’s role in preventing NASH. The study found that curcumin inhibits the activation of hepatic stellate cells, which form scars in the liver following damage.

Turmeric for disease prevention
examiner.com November 2015
Turmeric is made up of compounds called curcuminoids, named for the most well known and main active compound, curcumin. Curcumin is a strong antioxidant and arguably the most effective anti-inflammatory compound, not only fighting inflammation when it occurs, but stopping at the source, before it even begins. It is now believed that every chronic disease, including heart disease, thyroid disease and diabetes, has a strong correlation with chronic internal inflammation that you may not know even exists in your body. That said, regulating your body’s silent inflammatory response by utilizing turmeric and curcumin not only helps manage chronic disease, but is an important disease preventative. In fact, curcumin is so powerful that it is said to rival some anti-inflammatory drugs, even preventing fat accumulation and rebound, a common symptom of chronic inflammation. That is because of it’s anti-angiogenic properties and it’s ability to lower cholesterol levels, thusly reducing overall weight loss.

Turmeric prevents fear from being stored in the brain
Mail Online, November 2015
A spice commonly used in curry could help erase bad memories, according to a study. Curcumin, a bright-yellow compound found in the root of the Indian spice turmeric, prevented new fear memories being stored in the brain, and also removed pre-existing fear memories, researchers found. It is hoped that the findings will help develop treatments for people suffering with psychological disorders. Psychologists from the City University of New York trained rats to become scared when they heard a particular sound. Scientists assumed the creatures were frightened when they froze. Hours later, when the same sound was played to the rats, those who had been given ordinary food froze. Yet the rats fed the curcumin-rich diet didn’t freeze, suggesting their fearful memories had been erased. Professor Glenn Schafe, who led the study, said: ‘This suggests that people suffering from post-traumatic stress disorder and other psychological disorders that are characterised by fearful memories may benefit substantially from a curcumin-enriched diet.’

Health Benefits of Curcumin
BT.com November 2015
Curcumin, a substance found in turmeric, is thought to reduce swelling and ease the pain associated with inflammation of the joints. Curries may help to prevent Alzheimer’s… Researchers have found that curcumin can also reduce the build-up of plaques on the brain that cause Alzeihmer's by as much as 50%. …And cancer Turmeric has been found to reduce the risk of several types of cancer; while a study found that people consuming high levels of cumin were less likely to develop prostate cancer.

Turmeric is hot and may benefit more than just your taste buds
Today, October 2015
Many of the studies have focused on curcumin, which researchers say is the active ingredient in turmeric. A Thai study published in 2014 found that curcumin capsules dulled the pain in arthritic knees just as well as the popular OTC NSAID ibuprofen. A 2015 study in a rat model of Alzheimer's disease found that the spice improved working memory. In fact, the more curcumin the rats consumed, the better their memories got.

The super healthy trendy root
Today, October 2015
Turmeric is getting lots of attention because the active ingredient in it, curcumin, has potent anti-inflammatory properties and has been shown to be beneficial in treating symptoms of Crohn's disease, Irritable Bowel Syndrome and stomach ulcers. There is also research (in both animals and humans) that shows that curcumin may help prevent and slow the spread of cancer, make chemotherapy more effective and protect healthy cells from radiation damage.

Health benefits of turmeric
The Gleaner, October 2015
Turmeric's unique contribution to prostate-cancer-fighting is its extraordinary anti-inflammatory properties, provided chiefly by its natural primary component, curcumin. Reducing inflammation with curcumin reduces the metastases that ultimately kill prostate cancer patients. Curcumin also down-regulates genes involved in adhesion, motility, and invasiveness that prostate-cancer cells need to invade and spread. Curcumin specifically inhibits prostate cancer-cell production of PSA by blocking its genetic expression. At the same time, it also reduces activation of the androgen receptors on cancer cells that trigger increased production of PSA. But the whole turmeric root also contains important oils and other substances that enhance curcumin's absorption and have health benefits of their own, including anti-cancer actions. Turmeric also inhibits the growth of stem cells that give rise to breast cancer without harming normal breast cells.

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update
Food and Chemical Toxicology, October 2015
Naturally occurring polyphenols (like curcumin, morin, resveratrol, etc.) have gained importance because of their minimal side effects, low cost and abundance. Curcumin (diferuloylmethane) is a component of turmeric isolated from the rhizome of Curcuma longa. Research for more than two decades has revealed the pleiotropic nature of the biological effects of this molecule. More than 7000 published articles have shed light on the various aspects of curcumin including its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer activities. Apart from these well-known activities, this natural polyphenolic compound also exerts its beneficial effects by modulating different signalling molecules including transcription factors, chemokines, cytokines, tumour suppressor genes, adhesion molecules, microRNAs, etc. Oxidative stress and inflammation play a pivotal role in various diseases like diabetes, cancer, arthritis, Alzheimer's disease and cardiovascular diseases.

Researchers make breakthrough in understanding cancer
The Eagle, October 2015
Long-chain omega-3 fatty acids found in fish oil, as well as curcumin, found in turmeric, are in a unique class of dietary bioactives that we have termed membrane-targeted dietary bioactives, or MTDBs. Previous studies suggest that dietary bioactives such as curcumin, as well as fish oil and omega-3 fatty acids, are effective as colorectal cancer preventive agents. Long-chain fatty acids found in fish oil, as well as curcumin and capsaicin, which is found in hot peppers, fall into this unique class because they have both hydrophilic, or water-loving, properties and lipophilic, or fat-loving, properties. Due to their characteristics, these are capable of disturbing cell membrane organization. Membrane-targeted dietary bioactives, such as curcumin and capsaicin, squeeze in between spaces within the membrane leading to disruption of lipid and protein interactions.

Curcumin supplementation: more glycogen, less lactic acid, more stamina, more strength
Ergo-log.com September 2015
Curcumin [structural formula shown below] has been the subject of heated interest from molecular nutritionists in recent years. That's not surprising if you look at the long list of the benefits of curcumin: it inhibits muscle breakdown, enhances the positive effects of exercise on the blood vessels, boosts testosterone levels, inhibits estradiol, strengthen bones

5 Secret Health Benefits of Spicy Food
Desi Blitz, September 2015
Curcumin in particular is said to have anti-inflammatory properties, which break down the bad brain cells linked to Alzheimer’s disease.

Turmeric Blocks Cancer Cells – Which Chemotherapy Can’t Do
Food World News, September 2015
A recent study published in the Asian Pacific Journal of Cancer Prevention, for instance, found that a dose-dependent administration of curcumin effectively activated apoptosis of liver cancer cells, meaning it prompted these harmful cells to die.

How to improve your circulation
Stuff.co.nz, September 2015
Ginger, similar to spicy peppers, can help blood flow, as can turmeric root, which also has anti-inflammatory properties. Turmeric contains curcumin, which is not only a wonderful antioxidant, it also assists blood flow.

Curcumin inhibits
Lab Invest,. September 2015
These findings characterized a novel mechanism by which curcumin modulated hepatocyte EMT implicated in treatment of liver fibrosis

A glass of turmeric
DailyTimes.com September 2015
The major medicinal value and health benefits of turmeric are due to its main ingredient curcumin. Curcumin serves as an anti-inflammatory agent and also possess anti-bacterial and anti-viral properties. These properties make it a powerful healing agent in conditions like common cold. The anti-inflammatory action of curcumin aids in relieving the chest congestion which typically accompanies common cold. Curcumin also helps in boosting immunity and hence makes children less susceptible to such infections. When taken with milk, the absorption of curcumin in the body is enhanced significantly leading to a quick relief from common cold.

Rediscovering the Cancer-Fighting Power of Turmeric
Asbestors.com August 2015
Historical evidence dating back thousands of years shows people in China and India often used curcumin to treat a number of conditions, from coughs and colds to skin diseases and wounds. Although it's been touted for its anti-inflammatory and antioxidant properties, tests to confirm further medicinal properties over the last few decades show mixed results. But the popular spice is back in the limelight thanks to modern clinical trials evaluating the compound's cancer-fighting properties. Clinical Trials Involving Curcumin and Cancer Many studies have shown curcumin can suppress tumor cells and is safe to consume even at high doses. Researchers at Case Western Reserve University School of Medicine in Ohio and Georg-Speyer-Haus research institute in Frankfurt, Germany, published a study in September 2014 titled, "Curcumin, Special Peptides Boost Cancer-Blocking PIAS3 to Neutralize Cancer-Activating STAT3 in Mesothelioma." The study on tissue samples showed how curcumin activates the specific protein that can slow or stop the growth of mesothelioma cells.

Focus on herbs that can treat diabetes
TheHindu.com August 2015
The most active component of turmeric is curcumin, a potential therapeutic agent used in diabetes and related complications. Curcumin could alleviate most aspects of diabetes including insulin resistance, hyperglycemia, hyperlipidemia, islet apoptosis and necrosis effectively. Moreover, Curcumin is safe and relatively inexpensive.

Three reasons turmeric is a boon for diabetics
TheHealthSite.com August 2015
The antioxidant, antimicrobial, anti-inflammatory, and anti-glycaemic properties of curcumin present in turmeric, helps to strengthen the immune system and fight various infections and viruses. Here are some natural remedies that help you boost immunity and stay safe. It helps in weight management: Obesity is a major risk factor of diabetes, accumulation of abdominal fat makes insulin production difficult. However, curcumin helps to control triglyceride and cholesterol levels in the body, improve digestion, prevent the accumulation of harmful fats. This helps in weight management, an important way to manage diabetes or prevent its onset.

Top 10 super-spices
Madison.com August 2015
Curcumin is more effective slowing down the development of Alzheimer’s disease than many medications, because it decreases inflammation and oxidation in the brain. This spice also speeds up the recovery time from strokes as well. Turmeric and its active ingredient, curcumin, are also highly effective against diseases like irritable bowel disease, ulcerative colitis, Crohn’s, and arthritis. Turmeric also improves liver function, lowers homocysteine and prevents heart disease.

Curcumin shows promise for treatment of mild-to-moderate ulcerative colitis
Healio.com August 2015
“The findings of this trial suggest that curcumin as add-on therapy with optimized mesalamine is superior to optimized mesalamine alone in inducing clinical remission in patients with active mild-to-moderate UC,” the researchers concluded.

New Findings Support Curcumin as Derivative for Use in Fighting Mesothelioma
MesotheliomaHelp.com August 2105
According to researchers from Flinders Medical Centre, a teaching hospital and medical school in South Australia, curcumin, the active ingredient in turmeric and the spice that gives curry its yellow color, inhibited the growth of mesothelioma tumor cells in human patient cells. Prior research was focused on animal models. “Curcumin – which can be taken orally in tablet form – has virtually no side effects, and could be used alone in patients too unwell to tolerate other therapies, or in conjunction with other drugs,” said lead researcher and Associate Professor Sonja Klebe, from the Department of Anatomical Pathology at Flinders, in a July 2 article in The Lead. “It may improve treatment response and allow reduction of standard drugs, improving quality of life,” added Klebe... The researchers found that the spice helps combat the cancer by directly affecting the blood supply to the tumors.

3 Reasons to Include Turmeric in Your Diet
US News & Health Report, August 2015
The magic of turmeric resides in the roots, specifically in the chemical compound called curcumin. Curcumin is a polyphenol – a chemical compound found in plants with antioxidant properties and myriad therapeutic attributes. In 2007, a study in Advances in Experimental Medicines and Biology, went so far as to state that, "Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal and anticancer activities, and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses."

Turmeric Rx: Centuries-old Indian spice may have multiple health benefits
Pittsburgh Post-Gazette, August 2015
Curcumin can help prevent or treat a wide spectrum of cancers, inflammatory conditions, autoimmune problems, neurological ailments including Alzheimer’s disease, cardiovascular disease, diabetes and diabetes neuropathy, among other metabolic diseases. Interest in turmeric and curcumin began decades ago when researchers began asking why India has some of the lowest rates of colorectal, prostate and lung cancer in the world, compared with the United States, whose rates are up to 13 times higher. They traced India’s advantages largely to its diet staple of curry powder, which is a combination of spices, with turmeric as a main ingredient. A recent review published in the journal Molecules said studies to date “suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases.” An M.D. Anderson Cancer Center review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that “plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.” Yet another M.D. Anderson study found that curcumin exhibits “antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities,” all bolstering its “potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease and other chronic illnesses.”

Exciting research shows curcumin spice could help treat mesothelioma
EmaxHealth.com July 2015
Curcumin is known for its anti-inflammatory and anti-cancer properties. The turmeric derivative has the ability to stop the growth of mesothelioma, found in animal lab experiments. Now researchers have taken things a step further by testing curcumin's anti-cancer effect in human mesothelioma cells Associate Professor Sonja Klebe, from the Department of Anatomical Pathology at Flinders Medical Centre said in a media release: “Importantly, this breakthrough allows us to predict if a certain patient is likely to benefit from therapy.” Advertisement Current therapy for mesothelioma involves trying to keep the cancer from growing and spreading to other organ. Surgery is not an option for everyone. Chemotherapy has been only partially successful. Curcumin halts blood supply to mesothelioma tumors Klebe explained curcumin has the ability to stop new blood vessels from growing. Cutting off the blood supply to cancer has been a focus of treatment. But the researchers were able to show for the first time that mesothelioma cells form 3-dimensional tubes. “This may explain the poor results of trials with the standard drugs, because they do not target this type of blood vessel formation," Klebe says. The researchers thinks curcumin has a direct affect on mesothelioma tumor growth in addition to stopping blood vessels from growing. “Curcumin – which can be taken orally in tablet form - has virtually no side effects, and could be used alone in patients too unwell to tolerate other therapies, or in conjunction with other drugs. It may improve treatment response and allow reduction of standard drugs, improving quality of life,"

Treating Mesothelioma with Curcumin: Success May Be Predictable
SurvivingMesothelioma.com July 2015
Curcumin is the plant polyphenol that gives turmeric its yellow hue and spicy flavor. It has anti-inflammatory properties and has been shown to inhibit the growth of mesothelioma cells from animal models in the laboratory. Now, for the first time, researchers in Australia say they have successfully done the same thing with human cells taken from their own mesothelioma patients. Researcher Sonja Klebe, an Associate Professor at Flinders Medical Centre in South Australia where the new research was conducted, says the breakthrough will allow doctors to predict whether or not a certain mesothelioma patient will benefit from treatment with curcumin. The research at Flinders may also help explain why curcumin may sometimes work even better than traditional drugs to fight mesothelioma. Dr. Klebe says she and her research colleagues have discovered, for the first time, that mesothelioma cells may be capable of giving rise to their own blood vessels to feed growing tumors. Traditional mesothelioma medications only target blood vessel growth arising from surrounding stromal cells. “This may explain the poor results of the standard drugs because they do not target this type of blood vessel formation,” explains Dr. Klebe. Unlike these drugs, curcumin does appear to impact this type of blood vessel formation, potentially slowing or even reversing the growth of mesothelioma tumors. Curcumin can be taken in a pill form and has virtually no side effects. If the new research findings can be confirmed, Dr. Klebe says curcumin could be added to the standard treatment regimen for some mesothelioma patients, making it possible to reduce the amount of side-effect producing medications they have to take. Mesothelioma is an extremely rare and hard-to-treat cancer affecting an estimated 2,500 American patients every year. It is directly liked to asbestos exposure.

Spicy treatment for aggressive cancer
Southern Health News, Flinders Medical Center Publication, July  2015
Scientists at Flinders Medical Centre say they have successfully used the plant polyphenol curcumin to slow the growth of mesothelioma cells taken from their own patients. To understand how this new research may impact future treatment, click here to read the article Surviving Mesothelioma has just posted. Curcumin comes from the plant that produces the spice turmeric. Although it has been used to slow the growth of mesothelioma cells taken from animal models, the new research represents the first time the same thing has been done with cells from human mesothelioma patients.

Rediscovering the Cancer-Fighting Power of Turmeric
Asbestos.com July 2015
Historical evidence dating back thousands of years shows people in China and India often used curcumin to treat a number of conditions, from coughs and colds to skin diseases and wounds. Although it's been touted for its anti-inflammatory and antioxidant properties, tests to confirm further medicinal properties over the last few decades show mixed results. But the popular spice is back in the limelight thanks to modern clinical trials evaluating the compound's cancer-fighting properties. Clinical Trials Involving Curcumin and Cancer Many studies have shown curcumin can suppress tumor cells and is safe to consume even at high doses. Researchers at Case Western Reserve University School of Medicine in Ohio and Georg-Speyer-Haus research institute in Frankfurt, Germany, published a study in September 2014 titled, "Curcumin, Special Peptides Boost Cancer-Blocking PIAS3 to Neutralize Cancer-Activating STAT3 in Mesothelioma." The study on tissue samples showed how curcumin activates the specific protein that can slow or stop the growth of mesothelioma cells. Professor of medicine at Case Western Reserve University and lead researcher of the study, Afshin Dowlati, M.D., told Asbestos.com the study "is very significant." Although the study wasn't performed on humans, Dowlati said curcumin "has shown clearly that it can reduce the cancer growth."

COX-2 inhibitors, conventional and natural, including curcumin
MyDigitalFC.com July 2015
Curcumin, the herbal aspirin, has been shown to inhibit certain growth factors. Every tumour needs blood supply and curcumin seems to impede them. Research suggests that curcumin ‘reawakens’ a key tumour-suppressor gene. It also inhibits metastases, especially in prostate and breast cancer, and quells other cancer cells, besides preventing the re-growth of cancer stem cells which populate the core of several tumours. New research hails curcumin as a ‘holistic’ anti-cancer herb, because of its success in not only halting cancer formation, replication and spread, but also providing the synergy to other anti-cancer drugs, while protecting healthy cells and organs. Research in the UK evidences that curcumin and chokeberry, for instance, can work together to induce cancer cell death (apoptosis) and prevent the spread of malignant cancer cells. Studies also suggest that curcumin can prevent cancer stem cells from re-growing the tumour. Recent research has shown curcumin can dexterously counter the dangerous effects of hormone replacement therapy (HRT) and its hazardous relationship with breast cancer. According to clinicians women could take curcumin supplements to protect themselves from developing progestin-accelerated tumours, primarily because synthetic progestin increases vascular endothelial growth factor (VEGF), a protein that helps form the blood supply to developing tumours. Curcumin inhibits VEGF and, thus, reduces the potential of breast cancer to proliferate.

Formation of Neural Tube Defects Reduced by Curcumin
EndocrinologyAdvisor.com July 2015
Curcumin appears to reduce high glucose-induced neural tube defect (NTD) formation by blocking cellular stress and activation of caspases, according to an experimental study published in the June 4 issue of the American Journal of Obstetrics & Gynecology... Under high-glucose conditions, curcumin suppressed oxidative stress in embryos. Treatment correlated with reductions in the levels of the lipid peroxidation marker, 4-hydroxynonenal, nitrotyrosine-modified protein, and lipid peroxides. In addition, curcumin blocked endoplasmic reticulum stress and abolished caspase 3 and 8 cleavage in embryos cultured under high-glucose conditions.

Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis
Am J Obstet Gynecol July 2015
Curcumin reduces high glucose-induced NTD formation by blocking cellular stress and caspase activation, suggesting that curcumin supplements could reduce the negative effects of diabetes on the embryo. Further investigation will be needed to determine if the experimental findings can translate into clinical settings.

5 supplements every man should take
Curcumin has been studied as a potential cancer-fighting agent and has demonstrated an ability to reduce prostate cancer tumors. The authors of a new study in Tumour Biology, for example, reported on a mechanism by which curcumin inhibits the growth of prostate cancer cells. Curcumin also helps support prostate health in men who have prostatitis and benign prostatic hyperplasia. In addition, the compound is a potent antioxidant valued for its ability to reduce inflammation and pain in conditions such as osteoarthritis, as well as act as a blood thinner and immune-system booster. Curcumin has shown anti-diabetic effects and reduced diabetic complications.
Curcumin inhibits growth of prostate carcinoma
Tumour Biology July 2015
Prostate cancer (PC) is a prevalent cancer in aged men. Curcumin is an active ingredient that has been extracted from the rhizome of the plant Curcuma longa. Recently, a potential of Curcumin against PC has been reported in PC

West discovers health benefits of Indian spice turmeric
 A recent review published in the journal Molecules said studies to date "suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases." An M.D. Anderson Cancer Center review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that "plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases." Another M.D. Anderson study found that curcumin exhibits "antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities," all bolstering its "potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses.

Agents for Treating Alzheimer's Disease
Scicasts June 2015
They investigated the specific interactions between a short APP peptide and curcumin derivatives for the first time worldwide, using protein-ligand ...
Turn to turmeric for better health, experts say
Dr Joseph Maroon, the noted University of Pittsburgh Medical Centre neurosurgeon, says he uses curcumin supplements as part of his health regimen as an ultra-marathon runner. He also recommends the use of curcumin and fish oil to his patients with pain and inflammation from degenerative conditions of the spine, neck and lower back. He said 17,000 Americans die each year from over-the-counter, non-steroidal pain medications. He was lead author of a 2006 study, Natural anti-inflammatory agents for pain relief in athletes, that concludes that "Curcumin's therapeutic effects are considered comparable to pharmaceutical nonsteroidal medications ... but with a major difference in that this compound is relatively nontoxic and free of side-effects.

More turmeric
An M.D. Anderson Cancer Centre review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that "plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases." Yet another M.D. Anderson study found that curcumin exhibits "antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities," all bolstering its "potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease and other chronic illnesses." .

Centuries-old Indian spice may have multiple health benefits
Interest in turmeric and curcumin began decades ago when researchers began asking why India has some of the lowest rates of colorectal, prostate and lung cancer in the world, compared with the United States, whose rates are up to 13 times higher. They traced India’s advantages largely to its diet staple of curry powder, which is a combination of spices, with turmeric as a main ingredient. A recent review published in the journal Molecules said studies to date “suggest that chronic inflammation, oxidative stress and most chronic diseases are closely linked, and that antioxidant properties of curcumin can play a key role in the prevention and treatment of chronic inflammation diseases.

Turmeric Rx: Spice is cited for health benefits
Hamilton Spectator June 2015
Over the centuries, the rootlike stem of the Curcuma longa plant has been used to make yellow dyes and spike food with some tasty zing. But an ever-growing mountain of evidence shows that boldly coloured turmeric with its earthy, bitter-gingery taste may offer a plethora of potential health benefits. Multiple studies — most originating in India, Europe and Australia — show that turmeric, and especially its colour-rich constituent of curcumin, can help prevent or treat a wide spectrum of cancers, inflammatory conditions, auto-immune problems, neurological ailments including Alzheimer's disease, cardiovascular disease, diabetes and diabetes neuropathy, among other metabolic diseases.
Getting to the Root of the Turmeric
In fact, one of the latest studies found that curcumin supplements (the active compound in turmeric) helped ease post-exercise muscle pain.
Research points to the health benefits of turmeric and curcumin in the diet
Multiple studies — most originating in India, Europe and Australia — show that turmeric, and especially its color-rich constituent of curcumin, can help ..
The real fountain of youth
Curcumin is currently the focus of much study for its ability to help repair DNA, especially epigenetic malfunction. Epigenetic mechanism is how the ...
Spices that prevent cancer
Curcumin: This is the king of spices when it comes to dealing with cancer diseases, besides it adding a zesty colour to our food on the platter.
The Possible Disease-Fighter in Your Spice Rack: The Many Benefits of Turmeric and Curcumin
Researchers have found that turmeric and curcumin fights the disease on a number of different levels. In a study published in the journal Clinical Cancer Research, scientists analyzed the saliva of people with head and neck cancers before and after they chewed curcumin tablets. They found that the compound suppressed two cell-signaling pathways known to stimulate the growth of these cancers.  Meanwhile, other laboratory research reveals that curcumin reduces the activity of epidermal growth factor receptors, which play a role in the spread of breast, prostate, and lung cancers. By blocking these receptors, proteins responsible for the proliferation cancerous cells aren't able to activate, thereby slowing the growth of tumors and the disease.
In a review of research published in the AAPS Journal, Jayaraj Ravindran, Ph.D., a researcher from MD Anderson Cancer Center in Houston writes, "Our review shows that curcumin can kill a wide variety of cancer cells through diverse mechanisms."  A growing stack of research indicates that curcumin can encourage apoptosis, or the death of cancerous cells, which can prevent the growth of cancerous tumors in the body. Curcumin binds to more than 30 different proteins, which may block cancer cells from transmitting factors important for their growth and activate pathways that lead to their death. What's more, Ravindran and his team identified more than 40 biomolecules involved with cell death that are influenced by curcumin.  Because curcumin fights cancer on so many different levels, it's able to outsmart the disease and prevent cancer cells from developing a resistance to treatment -- a common problem for cancer researchers. As Ravindran writes in his review, "Because of the numerous mechanisms of cell death employed by cucurmin, it is possible that cells may not develop resistance to curcumin-induced cell death."  In another review of research on curcumin, researcher Muthu K. Shanmugam, Ph.D., of the Yong Loo Lin School of Medicine at the National University of Singapore, agrees: "A plethora of in vitro and in vivo research together with clinical trials conducted over the past few decades substantiate the potential of curcumin as an anti-cancer agent ... Clinical trials with curcumin indicate safety, tolerability, non-toxicity (even up to doses of 8,000 milligrams per day), and efficacy."
Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate
Nature.com June 2015
We previously reported that curcumin has potent antifibrotic effects in vivo and in vitro, but the underlying mechanisms are not fully elucidated.
Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen
Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells...
Research is confirming benefits of curcumin
Among its active ingredients is curcumin, which is being actively studied for its anti-inflammatory, antioxidant, antimicrobial and cancer-fighting .
Study: Curcumin May Help Fight Oral and Cervical Cancer
According to Mishra, the natural antioxidant and the key ingredient of turmeric, curcumin, has the cancer-fighting properties. The research has claimed .
Study Finds Turmeric Can Help Treat Oral Cancers
India West May 2015
An antioxidant present in turmeric, called curcumin, has proven effective for the treatment of the human papillomavirus. (Simon A. Eugster/Wikipedia ..
Alternative Therapies to Prevent Diabetes
Newsmax May 2015
Curcumin, the substance in turmeric spice that gives Indian curry its distinctive yellow color, is an anti-inflammatory that bestows many health benefits
The Arthritis Foundation Has Identified 9 Supplements for Arthritis Symptoms
Curcumin supplements are very popular among arthritis patients. Curcumin is an active ingredient of the medicinal spice turmeric and is known for its ...
Which foods are known to reduce bowel cancer risk?
Curcumin is the substance found in turmeric that gives the spice its unmistakable yellow colour. Curcumin is a known anti-inflammatory, and it may ...
Relieve inflammation the natural way
Turmeric and curcumin supplements are available, though some healthcare experts recommend whole turmeric over the isolated form of curcumin.
Turmeric Can Fight Oral And Cervical Cancer, Says Study
The Inquisitr April 2015
According to a study published in the journal E Cancer Medical Science, an antioxidant found in turmeric called curcumin – an active ingredient in the ...
Circadian Responses to Chemo
The Scientist April 2015
Curcumin, a component of the spice turmeric, is known to have anti-cancer properties, and researchers are testing it out as a potential therapeutic ...
Cures and curcumin -- turmeric offers potential therapy for oral cancers
EurekAlert April 2015
One of the herb's key active ingredients - an antioxidant called curcumin - appears to have a quelling effect on the activity of human papillomavirus ...
Curcumin from turmeric can heal muscle injuries, reveals new study
Scientist have found that the household curry spice curcumin, a member of the ginger family can help players recover from muscle injuries and ...
Try turmeric today
TV3.ie April 2015
This is because it contains something called curcumin, which has multiple benefits. So with this in mind, we are taking a look at just some of the ways ...
Turmeric a golden addition
It is thought that the curcumin properties found in turmeric are responsible for the anti-inflammatory, anti-parasitic, anticancer and antiseptic abilities.
Curry spice to overcome aches and sore muscles
Bristol Post April 2015
Doctors based at the Olympic Training Centre, in Barcelona, Spain, have been testing a new formulation of curcumin, a member of the ginger family ...
MIND Protocol: Lifestyle Plan Beats Alzheimer's
Newsmax April 2015
"Alzheimer's is 70 percent less common in India than in the U.S., likely because of the large amounts of curcumin that are used in curries and other ...
A: There are more than 7,500 scientific publications on curcumin, but much of the research for human health is still preliminary. Curcumin has been ...
The Spice That May Help Fight Breast Cancer
The Epoch Times April 2015
Exciting new research released in the journal Clinical and Experiential Medicine found that curcumin, a naturally-occurring substance found in the ...
Dietary curcumin may boost brain DHA: Study
Increased intake of curcumin could boost levels of docosahexaenoic acid (DHA) in the brain by enhancing its conversion from other omega-3 ...
One of the Best Antibiotics Could Be in Your Kitchen
Dozens of studies have revealed many clinical benefits associated with curcumin. They include antioxidant properties, anti-inflammatory activity and protection against chronic diseases such as diabetes and cancer. The molecule also has antimicrobial activity and is effective against bacteria, viruses, and even fungi. For anyone looking for an antibiotic alternative, this particular chemical is a potential golden goose.
Curcumin may be promising treatment for cancer
Curcumin, a compound found in turmeric, may be a promising treatment for a variety of cancers and other inflammatory diseases, according to an ...
The life in your spice – the health benefits of flavor
Another star in the spice rack is turmeric, which contains curcumin, a compound now being studied for its potential to prevent cancer and Alzheimer's ...
Spice Proves Effective Against Cancer
Newsmax April 2015
A new study has found that curcumin, a chemical compound found in turmeric, is a safe and promising treatment for most cancers and other ...
Curcumin proved effective at combating cancer
WA SCIENTISTS have helped re-affirm that curcumin, a chemical compound found in turmeric, is a safe and promising treatment for most cancers and ...

Topical Application of Turmeric Curcumin for Cancer
Care2.com March 2015
In my video, Turmeric Curcumin and Colon Cancer, I talked about a study where researchers showed that, by taking curcumin, the yellow pigment in

The Spice that Stops Muscle Pain in its Tracks
Care2.com March 2015
Exciting new research in the Journal of the International Society for Sports Medicine found that curcumin, one of the active ingredients in the spice ...

Turmeric Curcumin and Colon Cancer
Care2.com March 2015
The low incidence of bowel cancer in India is often attributed to natural antioxidants such as curcumin, the yellow pigment in the spice turmeric, used ...
The Spice that May Help Fight Breast Cancer
Care2.com March 2015
Both turmeric and curcumin supplements are readily available in most health food stores or from your natural health professional.

4 Natural Supplements That Are as Powerful as Drugs
EcoWatch March 2015
Garlic and curcumin are two natural supplements that boost your immune health. ... Curcumin fights inflammation at the molecular level by blocking an ...
Turmeric May Reduce Brain Damage, Ease Memories in Alzheimer's, PTSD
The substance, called curcumin, may be helpful in treating Alzheimer's disease and various psychological conditions that stem from fearful memories.
These Are The Only 3 Supplements I'll Take
Care2.com March 2015
Curcumin: About three years ago, I began to notice all the studies reporting the broad, well-documented potential of curcumin, the active ingredient

Winter Depression
Newsmax Health March 2015
A study at Baylor University found that curcumin, the main compound in the spice turmeric, worked as well as the popular antidepressant Prozac.
Aussie researchers trial turmeric for Alzheimer's
6minutes March 2015
Sydney researchers are using brain amyloid imaging to test the effects of curcumin – the active ingredient of the spice turmeric

6 foods that help fight cancer
Cosmopolitan February 2015
This popular curry spice contains an active compound called curcumin (it's what gives turmeric its bright yellow-orange colour) which has been shown to display powerful anti-cancer activity. In fact, curcumin has the most evidence-based literature supporting its use against cancer of any nutrient. Professor Bharat Aggarwal, from the MD Anderson Cancer Center in Texas goes as far as saying, "No cancer has been found, to my knowledge, which is not affected by curcumin." Pretty powerful stuff then!

Turmenic Can Erase Bad Memories And Fight Mental Disorders
Wall Street OTC February 2015
The research stated that an ingredient found in turmenic, called curcumin is involved in the process of both helping the printing of the new fears a person is dealing with and also at erasing existent negative memories. This new discovery, might come in the help of researchers for developing treatments for people suffering from mental disorders.

Turmeric: The New Superfood
Inquisitr.com February 2015
Curcumin (not related to cumin) is an antioxidant and the active ingredient in turmeric. Although it is continuously being studied, curcumin has been shown to inhibit several types of cancer cells. According to the American Cancer Society, turmeric is mostly used as an anti-inflammatory herbal remedy, with fewer side effects than common pain relievers.

Top Herbs, Latest Research
naturalproductsinsider.com February 2015
Curcumin has sparked a variety of scientific exploration into new areas, as research has recently indicated the compound can boost levels of the omega-3 docosahexaenoic acid (DHA) in the brain, where it can positively affect cognitive health. Also, drug discovery scientists have focused on novel analogs of curcumin in an effort to find compounds that have similar health benefits and overcome some of the absorption and stability challenges with the herb.

Turmeric Beneficial for Brain Health
Newswire.net February 2015
A recent study showed that curcumin encourages the immune system to send macrophages to the brain. A clinical trial was performed that involved people with severe cognitive decline to test the effects of curcumin. The results showed that participants taking curcumin had significantly higher levels of dissolved abnormal proteins in their blood compared to those in the placebo group. This study showed that curcumin has the ability to effectively pass into the brain, bind to beta-amyloid plaques and assist the body in their breakdown. Curcumin is one of the only substances known to have such a profound protective effect on the brain.

Curcumin: This compound in turmeric can boost your heart health
TheStar.com February 2015
Adding spice – in the form of curcumin supplements – to the daily diets of people with risk factors for heart disease may lower inflammation, a new study suggests.

Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials
Sciencedirect.com February 2015
This meta-analysis showed a significant effect of curcuminoids in elevating serum SOD and catalase activities, GSH concentrations, and reduction of serum lipid peroxides.

Effect of curcumin supplementation on physiological fatigue and physical performance in mice
Nutrients. February 2015
Curcumin is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities....Curcumin supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

Turmeric Beneficial for Brain Health
NewsWire.net, February 2015
A recent study showed that curcumin encourages the immune system to send macrophages to the brain. A clinical trial was performed that involved people with severe cognitive decline to test the effects of curcumin. The results showed that participants taking curcumin had significantly higher levels of dissolved abnormal proteins in their blood compared to those in the placebo group. This study showed that curcumin has the ability to effectively pass into the brain, bind to beta-amyloid plaques and assist the body in their breakdown. Curcumin is one of the only substances known to have such a profound protective effect on the brain

Curry spice linked to improved memory
The Guardian, February 2015
Curcumin, a bright-yellow compound found in the root of the Indian spice turmeric, prevented new fear memories being stored in the brain, and also removed pre-existing fear memories, researchers found.

Curcumin prevented new fear memories being stored in the brain and removed pre-existing fear memories
Mail Online, February 2015
Curcumin is known to have an anti-inflammatory effect on the body, and this may be how it works on fearful memories, said Professor Schafe.‘Inflammatory processes have been implicated in a wide range of diseases ranging from allergies to cardiovascular disease to Alzheimer’s,’ he said.‘Inflammation has also been implicated in psychological disorders such as depression, anxiety and post-traumatic stress disorder.‘Some of these same inflammatory pathways have also been implicated in memory formation, so it all fits.

Curcumin's ability to fight Alzheimer's studied
Science Daily, January 2015
Curcumin, a natural product found in the spice turmeric, has been used by many Asian cultures for centuries, and a new study indicates a close chemical analog of curcumin has properties that may make it useful as a treatment for the brain disease. “Curcumin has demonstrated ability to enter the brain, bind and destroy the beta-amyloid plaques present in Alzheimer’s with reduced toxicity,” said Wellington Pham, Ph.D., assistant professor of Radiology and Radiological Sciences and Biomedical Engineering at Vanderbilt and senior author of the study, published recently in the Journal of Alzheimer’s Disease.

The Spice Ingredient That Can Block Bad Memories
Time Magazine, January 2015
Curcumin, a compound found in turmeric that may have protective effects against neurodegenerative diseases, might one day help those with PTSD let go of bad memories, suggests a new rat study published in the journal Neuropsychopharmacology.

Reduce Heart Disease with Turmeric – It’s Just as Effective as Exercise and Cholesterol-Reducing Drug
The Raw Food World, January 2015
One study found that curcumin contains anti-thrombotic, anti-proliferative, and anti-inflammatory effects and can decrease the serum cholesterol level and protect against atherosclerosis. Several studies show the major benefit of curcumin for heart disease is improving the endothelium function in the lining of the blood vessels. Endothelium dysfunction is the main cause of heart disease and causes the endothelium to inefficiently regulate blood pressure, blood clotting, and other factors. Not only did curcumin help endothelial function, but also one study found that it’s just as effective as exercise.In addition, another study showed that it works just as well as the drug Atorvastatin. One study showed that 121 patients who underwent coronary artery bypass surgery were randomized to ingest either 4 grams of curcumin per day, a few days before and after the surgery, or a placebo. The results show that the group who ingested curcumin had a 65% decreased risk of experiencing heart attack whilst in the hospital. The authors state, “The antioxidant and anti-inflammatory effects of curcuminoids may account for their cardioprotective effects shown in this study.”

Treat Rheumatoid Arthritis with the Natural Healing Effects of Turmeric
The Raw Food World, January 2015
Curcumin is used to treat everything from skin and stomach ailments to infections and inflammations. Other research shows curcumin helps reduce Alzheimer’s. Now modern researchers have been intrigued enough to put turmeric’s many historical benefits to the test – even rheumatoid arthritis.

Turmeric associated with fewer neural tube defects in mice
2minutemedicine, January 2015
In the present work, authors investigate the impact of curcumin, a substance found in the turmeric plant, on NTDs and markers of oxidative stress in mouse embryos cultured in normal and high glucose environments. They found that embryos cultured in high glucose environments and treated with 20μM curcumin were less likely to experience oxidative stress and develop NTDs.

Curcumin in turmeric fights BP, diabetes: Study
Times of India, January 2015
The health benefits of turmeric are due to the presence of a yellow compound named curcumin. This compound is especially beneficial for fighting high blood pressure. Remarkably, this compound is not only helpful in regulating blood pressure but also effective in treating several late complications of diabetes like affecting eyes, blood vessels, kidney and brain.

A Common Kitchen Item Could Cure All Your Fears And Bad Memories
Carbonated.tv January 2015
Curcumin (a compound found in turmeric) has been found to possess the power to impair newly acquired and reactivated fear memories. The spice is vastly acknowledged for its medicinal properties, and contains anti-inflammatory bodies which are known to help with arthritis and stomach issues, among many other ailments.

Natural Interventions to Keep Your Eyesight Sharp as You Age
The Raw Food World, January 2015
 Curcumin, found in turmeric, contains a high amount of therapeutic polyphenol and is the reason for its golden color. Turns out that curcumin is able to protect against cataracts forming. (2) One study shows that curcumin had the potential to function as an anticataractogenic agent, which could possibly prevent the accumulation of calcium in the eye lens. (6) Another study showed the antioxidant effects of curcumin that appears to prevent oxidative damage and delay cataracts.

Curcumin and major depression: A randomised, double-blind, placebo-controlled trial
Neuropsychopharmacology. December 2014
Curcumin supplementation influences several biomarkers that may be associated with its antidepressant mechanisms of action. Plasma concentrations of leptin and endothelin-1 seem to have particular relevance to treatment outcome.

Curcumin inhibits proliferation of gastric cancer cells
World Journal of Surgical Oncology December 2014
Curcumin incubation significantly induced loss of MMP in SGC-7901 cells in a dose- dependent manner (P <0.05); the cell apoptotic rate also dramatically increased after curcumin incubation in a dose-dependent manner (P <0.05).

Curcumin inhibit leptin gene expression and secretion in breast cancer cells
Cancer Cell International December 2014
Curcumin inhibits the expression and secretion of leptin and it could probably be used as a drug candidate for the breast cancer therapy through the leptin targeting in the future.

Curcumin, curry are spice superstars
Harold-Review.com December 2014
More than 900 published research papers pertaining to curcumin’s anticancer activity. One of these papers found that curcumin has the ability to make some cancer cells commit suicide.

Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
Biological Research December 2014
Hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.

Curcumin and tackling mesothelioma
News Medical December 2014
As previous researchers had already demonstrated that curcumin can increase PIAS3, we used curcumin to increase the PIAS3 levels in mesothelioma cancer cells. When we exposed these cells to low levels of curcumin, we saw an increase in the intracellular levels of PIAS3. Furthermore, when we increased PIAS3, the activation of STAT3 decreased, and, in turn, the cancer cells started growing much more slowly or stopped growing altogether. So, curcumin affects mesothelioma cells by increasing the intracellular PIAS3 and therefore decreasing the STAT3 activation and cancer cell growth.

Five Benefits You Need To Know About The Ingredient That Helps Make Curry
YouthHealingMag.com December 2014
The active ingredient in turmeric is curcumin, which is known as a powerful antioxidant. This means it targets dangerous free radicals in the body and reduces the damage they are able to cause DNA and cells.A study in the Sept 2014 issue of Life Sciences performed an extensive review on curcumin and wound/injury healing. Researchers found turmeric (curcumin) to have beneficial properties that appear to speed the wound healing process. These modes of action include the modulation of inflammation and oxidation, the ability to improve granulation tissue formation, tissue remodeling, and deposition of collagen. Curcumin may be able to prevent the oxidation of cholesterol in the body. Since oxidized cholesterol is what damages blood vessels and builds up in the plaques that can lead to heart attack or stroke, preventing the oxidation of new cholesterol may help to reduce the progression of atherosclerosis and diabetic heart disease.

Unique Health Benefits Of Turmeric
Lifehacker November 2014
Curcumin, contained in turmeric, gives it powerful anti-oxidant properties, making it a strong agent against cancer. Experts say that turmeric is naturally anti-inflammatory, and while it's not a one-stop cure against the disease, it does inhibit neoplastic growth by preventing the formation of tumor blood vessels. About 30 studies exist that suggest curcumin has anti-tumor effect.

Oral curcumin shown effective in psoriasis
 Skin & Allergy News Digital Network November 2014
Studies have shown that curcumin has antiproliferative, antiangiogenic, and anti-inflammatory effects. In a small study by other investigators, topical turmeric not only successfully cleared psoriasis lesions, it also suppressed phosphorylase kinase activity, which is important to keratinocyte proliferation

How Curry Can Kill Cancer Cells
Care2.com October 2014
In cancer cells, curcumin, the pigment in the spice turmeric that makes curry powder yellow, upregulates and activates death receptors (as shown in human kidney cancer cells, skin cancer cells, and nose and throat cancer cells). Curcumin can also activate the death machine directly (as shown in lung cancer and colon cancer). Caspases are so-called “executioner enzymes,” that when activated, destroy the cancer cell from within by chopping up proteins left and right—kind of like death by a thousand cuts. And that’s just one pathway. Curcumin can also affect apoptosis in a myriad other ways, affecting a multitude of different types of cancer cells. It also tends to leave normal cells alone for reasons that are not fully understood. Overall, researchers “showed that curcumin can kill a wide variety of tumor cell types through diverse mechanisms. And because curcumin can affect numerous mechanisms of cell death at the same time, it’s possible that cancer cells may not easily develop resistance to curcumin-induced cell death like they do to most chemotherapy.”

Turmeric extract can have the potential to boost brain stem cells
TheRawFoodWorld,com October 2014
Curcumin is one of the ingredients in turmeric that exhibits over 150 potentially therapeutic activities and researchers have found it to play a significant role in improving Parkinson’s, Alzheimer’s, and stroke damage...Dr. William LaValley is one of the leading natural medicine cancer physicians. He actually devoted his time in researching the science of curcumin, which has the most evidence-based literature supporting its use against cancer of any other nutrient. He explained, “The curcumin molecule may cause either an increase in activity of a particular molecular target, or a decrease/inhibition of activity. Either way, studies repeatedly show that the end result is a potent anti-cancer activity.”

Wonder Herb
MyDigitalFC.com October 2014
Curcumin is the colouring principle of turmeric — it is the element that gives the herb its yellow hue. Aside from being the most important component of turmeric, curcumin is responsible for the herb’s anti-inflammatory effects. Research suggests that curcumin, like cayenne, another medicinal spice found in chillies, depletes substance P, the pain receptor and neurotransmitter, in the nerve endings (nociceptors). Research also suggests that curcumin and related compounds suppress pain through a mechanism similar to conventional coxib-2 inhibitors — the ‘new’ class of non-steroidal anti-inflammatory drugs (NSAIDs)...Laboratory and animal studies suggest that curcumin has the potential to prevent and treat various forms of cancer: colon, prostate, breast, and skin. As a matter of fact, there has been a substantial amount of research on turmeric’s anti-cancer potential and the results are promising. In one clinical study, researchers examined the pain-relieving properties of curcumin and/or whether it could suppress coxib-2 expression in human colon cancer cells. After exposing colon cancer cells to curcumin, they found the compound not only subdued cell growth, but also downgraded the expression of coxib-2 on the basis of a time- and dose-formatted chart. In addition, researchers observed that curcumin appeared to be a safe, natural coxib-2 inhibitor in human patients.

Carcinogen Blocking Effects of Turmeric
Care2.com October 2014
 Curcumin, present in the Indian spice turmeric, which is used in curry powder, is one such agent that is currently under clinical investigation for cancer chemoprevention.” According to their mode of action, chemopreventive agents are classified into different subgroups: antiproliferatives, antioxidants, or carcinogen-blockers. Curcumin belongs to all three, given its multiple mechanisms of action. Curcumin appears to play a role helping to block every stage of cancer transformation, proliferation, and invasion, and may even help before carcinogens even get to our cells. A study back in 1987 investigated the effects of curcumin on the mutagenicity (DNA mutating ability) of several toxins and found that curcumin was an effective antimutagen against several environmental and standard mutagenic and cancer-causing substance.

Curcumin inhibits breast cancer stem cell migration.
Stem Cell Research Therapy October 2014
Curcumin, a plant ployphenol, has several anti-tumor effects and has been shown to target CSCs. Here, we aimed at evaluating (i) the mechanisms underlying the aggravated migration potential of breast CSCs (bCSCs), and (ii) the effects of curcumin in modulating the same...Cumulatively, our findings disclose that curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative feedback loop.

Health Benefits Of Turmeric
Huffingtonpost.com October 2014
Curcumin, the compound in turmeric responsible for that bright hue, is behind a whole host of the health benefits attributed to the spice. A 2012 study examined one perk of curcumin in particular: the ability of the extract to prevent heart attacks among bypass patients. The study followed 121 patients who had bypass surgery between 2009 and 2011. Three days before surgery through five days after, half of the patients took curcumin capsules, while the other half took placebo pills. During their post-bypass hospital stays, more people in the placebo group experienced a heart attack (30 percent) compared with those in the curcumin group (13 percent), Reuters reported. While not a substitute for medication, the researchers pointed out, the antioxidant and anti-inflammatory properties of curcumin may contribute to as much as a 65 percent lower chance of heart attack among bypass patients. ... Among people with prediabetes, curcumin capsules were found to delay the onset of Type 2 diabetes in a 2012 study. Over nine months, study participants were given either curcumin supplements or placebo capsules. Just over 16 percent of people taking the placebo pill were diagnosed with Type 2 diabetes by the end of the study, while no one taking curcumin was. Again, researchers chalk these results up to the anti-inflammatory and antioxidant powers of the compound. ... While studies in humans are still in very early stages, lab and animal studies have shown promising effects of curcumin in the fight against cancer. Curcumin "interferes with several important molecular pathways involved in cancer development, growth and spread," according to the American Cancer Society, even killing cancer cells in the lab setting and shrinking tumors and boosting the effects of chemotherapy in animals.

Turmeric enhances mood in depression research trial
Medicalxpress.com October 2014
Curcumin was significantly more effective than the placebo in improving several mood-related symptoms in the volunteers. The compound had an even greater efficacy in a small subgroup of individuals with atypical depression, which can be characterised by significant weight gain or increased appetite and hypersomnia. "In animal-based studies curcumin has been consistently shown to have antidepressant effects and it has been hypothesised that curcumin would have antidepressant effects in people with major depression," said Dr Lopresti, who is a clinical psychologist in a private practice. "There have been a few positive human-based studies investigating the effects of curcumin in depression. However, this is the first randomised, double blind, placebo-controlled study and over the longest duration.

Shows Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism
Yumanewsnow.com October 2014
The researchers treated human colon cancer tumor cells with curcumin. "We discovered that curcumin turns off the active form of cortactin," said Radhakrishnan, who led the experiments in the lab. "Thus, when cortactin is turned off, cancer cells lose the ability to move and can't metastasize to other parts of the body." More specifically, curcumin "turned off" cortactin by interacting with, and activating, an enzyme known as PTPN1. This enzyme acts as a phosphatase to remove phosphate groups from cortactin – a process known as "dephosphorylation." "This effect, essentially known as 'dephosphorylating cortactin' correlated with reduced ability of colon cancer cells to migrate," Kiela said. "This suggests that curcumin reduces cancer cells' ability to migrate, meaning the cancer can't metastasize."

Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells
Biomedcentral.com October 2014
 Curcumin suppresses the expression level of FABP5 and PPARβ/δ in triple negative mammary carcinoma cells. By targeting the FABP5/PPARβ/δ pathway, curcumin prevents the delivery of retinoic acid to PPARβ/δ and suppresses retinoic acid-induced PPARβ/δ target gene, VEGF-A. Our data demonstrates that suppression of the FABP5/ PPARβ/δ pathway by curcumin sensitizes retinoic acid resistant triple negative breast cancer cells to retinoic acid mediated growth suppression.

Reverse Alzheimer’s, Parkinson’s and Rheumatoid Arthritis with ashwaganda, curcumin and Vitamin D
Therawfoodworld.com October 2014
It appears that ashwaganda, curcumin, Vitamin D and exercise may help the body remove amyloid protein, which is thought to cause diseases such as Alzheimer’s, Parkinson’s Disease, Rheumatoid Arthritis and several other amyloid diseases.

Oral curcumin may protect gut function
Healthcanal.com October 2014
Oral curcumin may be a viable therapy to improve intestinal barrier function changes caused by consuming a high-fat Western diet, according to a preclinical study by Virginia Commonwealth University School of Medicine researchers.

Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages
Journal of Translational Medicine October 2014
Curcumin exerts well-known anti-inflammatory and antioxidant effects and probably has a protective role in the atherosclerosis.

Curcumin fights Alzheimer's disease
Foodconsumer.org October 2014
A study led by scientists at Beijing University of Chinese Medicine in Beijing, China suggests taking curcumin supplements may help prevent Alzheimer’s disease...Curcumin is an important supplement that may be used to prevent or treat cancer, inflammatory diseases, cystic fibrosis, and diabetes mellitus and many other diseases in addition to Alzheimer's disease. 

Colon cancer metastasis blocked by curcumin
Oncologynurseadvisor.com October 2014
Curcumin, derived from the spice turmeric, blocks the protein cortactin in colon cancer.

Study promotes turmeric as promising anti-cancer agent
GroundReport.com October 2014
Curcumin could provide an alternate means to the prevention of cancer. The effect of curcumin as an antioxidant, antibacterial agent and anti-tumor agent are well documented and it also has a therapeutic or preventive effect on several other diseases. The study looks at the chemopreventive effects of curcumin in cancer-prevention with specific focus on curcumin’s effect on the regulation of cell signaling and genetic pathways. Further, the study notes that turmeric and curcumin show no significant toxicity at all.

Healthy Living with Ruth Holmes: Ancient herb used as treatment
Stroud News and Journal September 2014
The bright yellow pigment contains the active compound curcumin, which is found in the roots of certain tropical plants like turmeric, and has powerful anti-inflammatory actions.  Just like the non steroidal anti inflammatory medications, it blocks the formation of the pro-inflammatory prostaglandins, and leukotrienes (also inflammatory) but does not have the side effects on the stomach that the anti-inflammatory would. as an anti-inflammatory effect on the stomach.  Curcumin is highly recommended in osteoarthritis and rheumatoid arthritis as well as post operative inflammation.  Curcumin can also be used as a poultice for inflammatory skin conditions like psoriasis and eczema, this herb will not treat any pain, as its action is to reduce and prevent further inflammation from occurring which is what causes the discomfort in the first place.

Mesothelioma Patients May Benefit from Common Spice
MesotheliomaLawyerCenter.org September 2014
A new study on combating mesothelioma suggests that the component curcumin, found in the popular turmeric spice, may help fight mesothelioma by increasing protein inhibitors that can slow down the cancer. Conducted by experts and doctors at Ohio’s Case Comprehensive Care Center and Germany’s Georg-Speyer-Haus Institute for Biomedical Research, the study focused on a protein known as STAT3, which is known to trigger and promote the growth of cancers. When victims have a lower level a PIAS3, an enzyme that fights STAT3, they have an increased chance of dying from mesothelioma. However, when curcumin was administered to patients, their PIAS3 increased, thus fighting off the protein that increases cancer.

Get your glow from kitchen
Wonderwoman.intoday.in September 2014
Curcumin: An antioxidant derived from the turmeric root, its active ingredient can help calm swelling and reduce wrinkles and other signs of ageing.

Curcumin could slow down progression of lung lining cancer
Thehealthsite.com September 2014
Curcumin show promise in slowing the progression of mesothelioma, a cancer of the lung’s lining often linked to asbestos

Curcumin, The Asian Spice, Helps Fight Mesothelioma
Medicaldaily.com September 2014
Curcumin, has long been known for its cancer-inhibiting properties. But when it's combined with cancer-destroying peptides (bonded chains of amino acids), the resulting molecule promotes growth of a protein inhibitor known to combat the progression of mesothelioma.

Component in Spice May Help Slow Mesothelioma Growth
Survivingmesothelioma.com September 2014
Yet another study has demonstrated the potential mesothelioma-fighting properties of curcumin, an anti-inflammatory polyphenol that is the primary component in the spice turmeric. The latest study suggests that applying curcumin along with cancer-fighting peptides may increase the levels of a protein inhibitor that can slow the progression of mesothelioma.
October 2014

Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells
BMC Cancer September 2014
Treatment of retinoic acid resistant triple negative breast cancer cells with curcumin sensitized these cells to retinoic acid mediated growth suppression, as well as suppressed incorporation of BrdU. Further studies demonstrated that curcumin showed a marked reduction in the expression level of FABP5 and PPARbeta/delta. We provide evidence that curcumin suppresses p65, a transcription factor known to regulate FABP5.

Curcumin boosts testosterone level
ergo-log.com August 2014
Curcumin might be used as an alternative drug for the treatment of male infertility problems.

The new blockbuster nutrient?
Theage.com.au August 2014

Turmeric, with its active ingredient curcumin, are "blockbuster nutrients", according to professor Marc Cohen, head of Complementary Medicines at RMIT. "Turmeric is a powerful antioxidant which stops lipid oxidation and is anti-inflammatory," says Cohen, who devoted an entire chapter to turmeric in his book, Herbs and Natural Supplements: An Evidence-Based Guide. "It is a possible aid in preventing chronic degenerative diseases like Alzheimer's disease."

Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
Newindianexpress.com August 2014
Curcumin, the principal curcuminoid derived from turmeric influences several biological mechanisms associated with major depression, namely those associated with monoaminergic activity, immune-inflammatory and oxidative and nitrosative stress pathways, hypothalamus-pituitary-adrenal axis activity and neuroprogression, the study said. It is effective for the treatment of depressive symptoms in individuals with major depressive disorder. Curcumin is the substance in turmeric which gives the yellow color.

Eat to Beat Cancer
aarp.org August 2014
Laboratory studies have found that curcumin—the main ingredient in the spice turmeric, which gives curry its characteristic yellow color and sizzle—can fight against cancerous changes in healthy cells as well as slow the growth of malignant cells. Some evidence suggests that curcumin may also offer protection against brain tumors.

Turmeric’s Cardiovascular Benefits Found To Be As Powerful As Exercise
TheEpochTimes.com August 2014
Curcumin may prevent the age-associated decline in endothelial function in postmenopausal women

Powdered Gold
Cltampa.com August 2014
With more than 50 healing properties, modern research has found that the effectiveness of turmeric stems from curcumin, a natural compound it contains that is rich in antioxidants and anti-inflammatory ability. Thousands of animal and human studies have been conducted on turmeric and curcumin as both a preventive and curative agent. Current research targets curcumin’s efficacy in treating some of the world’s biggest health threats including cancer, heart disease, type 2 diabetes and Alzheimer’s disease.A number of curcumin studies have shown promising results. Curcumin can kill cancer cells in laboratory dishes and also slows the growth of the surviving cells. Curcumin has been found to reduce development of several forms of cancer in lab animals and to shrink animal tumors. On the U.S. National Library of Medicine’s website, 2,840 abstracts are listed about the study and benefits of turmeric and curcumin.

Mechanism of curcumin resistance to human cytomegalovirus in HELF cells
BMC Complementary and Alternative Medicine August 2014
Curcumin anti-HCMV effect may possibly be that curcumin concurrently alters host cell microenviroment and inhibits the HCMV antigen expressions. These findings may provide a basic understanding of the curcumin anti-HCMV effect and a novel strategy for further development of curcumin anti-HCMV treatment.

What's the one cooking trick for weight loss success?
Nola.com July 2014
Turmeric, the yellow ground spice you find in curry power, is a superspice when it comes to health and weight loss because of its active compound called curcumin. Hundreds of studies have been completed on its effectiveness against cancer, skin ailments, and lung health, just to name of few. But when it comes to the battle of the bulge, turmeric extract suppressed fat tissue growth in rodent models.

Turmeric branded latest superfood to protect against Alzheimer's
Business-Standard.com July 2014
Since inflammation is a major factor in the development of most chronic degenerative diseases including cardiovascular disease, allergies, type 2 diabetes and Alzheimer's disease, curcumin's anti-inflammatory power holds great promise in all of these conditions and many more. Murray said that the antioxidant activity of curcumin is superior to antioxidant nutrients like vitamin C and E, as they are effective against only water and fat-soluble pro-oxidants. Curcumin also helps in preventing LDL cholesterol - one of the worst kind of cholesterol - from getting oxidised and damaging arteries. and evidence is gaining that curcumin could also slow down ageing and prevent age-related diseases.

Healthiest Foods
palmbeachillustrated.com July 2014
Curcumin: An active ingredient in turmeric, this antioxidant has shown anti-cancer effects in laboratory studies and is anti-inflammatory.

Turmeric, Curcumin fights Alzheimer's disease
Foodconsumer.org July 2014
Curcumin one of the active ingredients found in turmeric has been known to protect against cancer, Alzheimer's disease, type 2 diabetes mellitus, allergies, arthritis and other chronic diseases. Epidemiological studies show that incidence of Alzheimer's disease in Southeast Asia where turmeric is commonly consumed as a spice was 4.4 times lower, compared to that found in countries where the price is not as commonly used.

Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice
Sciencedirect.com July 2014
Curcumin also reduced body weight gain and body fat without affecting fat distribution...However, at a high dose, curcumin suppressed development of steatohepatosis, reduced fibrotic tissue, and preserved glycogen levels in liver. Conclusion Curcumin through a series of complex mechanisms, alleviated the adverse effects of high fat diet on weight gain, fatty liver development, dyslipidemia, expression of inflammatory cytokines and atherosclerosis in Ldlr−/− mouse model of human atherosclerosis.

5 spices to keep in your medicine cabinet
FoxNews.com July 2014
Curcumin, the active compound in turmeric, is what makes this spice so special and turmeric happens to be one of the only readily available, edible forms of it. A 2007 study also showed curcumin to have anticancer properties, with the potential to fight malignant diseases, diabetes, allergies, arthritis and Alzheimer’s disease.

Evaluation of the Effect of Curcumin Capsules on Glyburide Therapy in Patients with Type-2 Diabetes Mellitus
Phytotherapy Research July 2014
The co-administration of curcumin capsules with glyburide may be beneficial to the patients in better glycaemic control. The lipid lowering and antidiabetic properties of the curcumin show as a potential future drug molecule.

The anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases
European Journal of Nutrition School of Life Sciences, College of Natural Sciences
Researchers reviewed the last ten years of curcumin science as it applies to supporting weight loss and preventing obesity-related disease. Their conclusion is, “The modulation of several cellular transduction pathways by curcumin has recently been extended to elucidate the molecular basis for obesity and obesity-related metabolic diseases. These findings might enable novel phytochemical treatment strategies as well as curcumin translation to the clinical practice for the treatment and prevention of obesity-related chronic diseases. Furthermore, the relatively low cost, safety and proven efficacy of curcumin make it advisable to include curcumin as part of healthy diet.”

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern target- Bokyung Sung 
Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor κB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail.

Antibiotic Properties Naturally Found in the Kitchen
Globalnews.com July 2014
Curcumin. Turmeric can boost immunity, helps to maintain cholesterol levels, and can even slow the process of aging. Researchers from the University of Texas M. D. Anderson Cancer Center have attested to the benefits.

  • Spice Rack...Or Medicine Chest?
    Nutrition Action Health Letter
    "Curcumin protects the brain cells in every animal model of traumatic brain injury, whether it's stroke, Alzheimer's disease, Huntington's disease, or mad cow disease," says Gregory Cole, associate director of the Alzheimer's Disease Center at the University of California, Los Angeles. "What's unique about Curcumin," Cole notes, "is that it binds directly to beta-amyloid deposits in the brain and reduces their size." Beta-amyloid is a protein fragment that builds up between brain cells of people with Alzheimer's disease....
    Science Daily Magazine
    How Plants Protect Us From Disease
    "Everyday foods, beverages, and spices contain healthful compounds that help us fight harmful inflammation. And, in doing that, these phytochemicals may also reduce our risk of diseases associated with chronic inflammation, including cancer and diabetes."
    Curcumin Curry Power
    Science News Magazine
    "The list of Curcumin's effects goes on and on, and they're all in your favor...in addition to its anti-inflammatory and antioxidant properties, Curcumin has several effects that may work in tandem to protect the brain from plaques in other ways. "If Curcumin had a single molecular target, it probably would not be as good a drug," M.D. Anderson Cancer Center in Houston. "But because it has multiple targets, it's very attractive."

    Health: The Fires Within
    Time Magazine
    Chronic inflammation may be the engine that drives many of the most feared illnesses of middle and old age. This concept is so intriguing because it suggests a new and possibly much simpler way of warding off disease. Instead of different treatments for, say, heart disease, Alzheimer's and colon cancer, there might be a single, inflammation-reducing remedy that would prevent all three.

    Science Daily Magazine
    Did evolution give us inflammatory disease?
    Researchers demonstrate that some variants in our genes which could put a person at risk for inflammatory diseases -- such as multiple sclerosis, Crohn's disease or rheumatoid arthritis -- have been the target of natural selection over the course of human history.
    The 'inflammation theory': Immune-system errors linked to more illnesses
    The Seattle Times
    "Medical researchers are becoming increasingly convinced that the most primitive part of the immune system (inflammation), may play a crucial role in some of the most devastating afflictions of modern humans, including heart disease, cancer, diabetes and possibly Alzheimer's."

    Obesity is Inflammatory Disease, Rat Study Shows
    Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans. PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself."

    Did evolution give us inflammatory disease?
    American Journal of Human Genetics
    Researchers demonstrate that some variants in our genes that could put a person at risk for inflammatory diseases such as multiple sclerosis, Crohn's disease or rheumatoid arthritis, have been the target of natural selection over the course of human history. The findings suggest that in the past these variants rose in frequency in the human population to help protect us against viruses, bacteria and other pathogens. But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely.
    Curcumin at M.D. Anderson Cancer Center
    The University of Texas, MD Anderson Cancer Center
    Curcumin has been shown to prevent a large of number of cancers in animal studies. Laboratory data indicate that Curcumin can inhibit tumor initiation, promotion, invasion, angiogenesis and metastasis. Epidemiological evidence indicate that incidence of certain cancers is less in people who consume Curcumin than in those who do not. Recent evidence indicates that, besides chemopreventive activity, Curcumin may also be effective in the treatment of cancer. Curcumin is currently under investigtion for its anti-cancer and anti-inflammatory effects at M. D. Anderson Cancer Center and other medical institutions.
    Curcumin Spice Healer
    Scientific American Magazine
    An ingredient in curry shows promise for treating Alzheimer's, cancer and other diseases.
    "A chapter in a forthcoming book, for instance, describes the biologically active components of Turmeric--Curcumin and related compounds called Curcuminoids--as having antioxidant, anti-inflammatory, antiviral, antibacterial and antifungal properties, with potential activity against cancer, diabetes, arthritis, Alzheimer's disease and other chronic maladies. And in 2005 nearly 300 scientific and technical papers referenced Curcumin in the National Library of Medicine's PubMed database, compared with about 100 just five years earlier. Scientists who sometimes jokingly label themselves Curcuminologists are drawn to the compound both because of its many possible valuable effects in the body and its apparent low toxicity. They ponder how the spice or its derivatives might be used, not just as a treatment but as a low-cost preventive medication for some of the most feared ailments. As a treatment, it also has some enticing attributes. Because Curcumin targets so many biological pathways, it could have benefits for cancer therapy: malignant cells may be slow to acquire resistance to it and so might have to go through multiple mutations to avoid the substance's multipronged attack." 1 2 3 4
  •   Previous news and studies on Curcumin and Turmeric.

      Medical studies and university clinical trials on Curcumin and Turmeric.

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      Scientific journals with published studies of Curcumin and Turmeric.

    American Journal of Physiology - 277: 320-29
    Age - 18:167-9
    Agents and Actions - 28:298-303
    Alimentary Pharmacology and Therapeutics - 13(2):245-249
    Alternative Medicine Review - 4(3):178-88, 6(2):167-187, 7(5):404-9
    American Journal of Clinical Nutrition - 64(5):761-766
    American Journal of Physiology: Gastrointestinal and Liver Physiology 284(1):85-95, 284(2):321-7
    American Surgeon - 64(1):47-51
    Annals of the New York Academy of Sciences - 973:250-4
    Anticancer Drugs - 8(5):470-81
    Anti Cancer Research - 11: 593-596,  19(5A):3675-80, 20(3a):1733-8,
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    Turmeric-Curcumin.com is our company and website, dedicated since 2000 to offering the highest quality Curcumin 95% extract, the best customer service, the lowest prices in the industry, and none of the marketing hype. Unlike other suppliers, we do not sell 500 products, or even 5 products. We remain dedicated and focused on the most powerful, healthful and important compound in botanical medicine; Curcumin, concentrated and standardized to 95% purified extract. This extraordinary spice extract has generated such interest that universities and medical centers around the world are continually conducting research studies and discovering new benefits, with multiple ongoing human clinical trials. Due to it's potent antioxidant power, Curcumin has been recognized as one of the most promising food-derived compounds in fighting a variety of degenerative diseases. The scientific evidence remains overwhelming, demonstrating the many health benefits via in vitro, in vivo and human clinical studies. You will receive 100% additive free products; no starch, no sugars or sweeteners, no artificial colors or flavors, no sodium, no soy, no yeast, no wheat, no gluten, no dairy, no preservatives, no black pepper extract or "bioperine" (actually a trademark of Piper nigrum by the Sabinsa corporation), no GMO, no dyes, no gums or any other unnecessary compounds. For any questions or comments, feel free to email support@turmeric-curcumin.com (or call and leave a message with your email) and we will respond as quickly as possible.

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